psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S34	R:R:V37	3.23	No	No	0	3	5
2	R:R:I38	R:R:Y35	4.84	No	No	0	3	4
3	R:R:T39	R:R:Y35	4.99	No	No	0	5	4
4	R:R:Q36	R:R:V98	5.73	No	No	0	4	6
5	R:R:A94	R:R:L43	4.73	No	Yes	0	7	7
6	R:R:L43	R:R:W387	7.97	Yes	Yes	0	7	8
7	R:R:G44	R:R:I47	3.53	No	No	0	4	7
8	R:R:I47	R:R:L90	5.71	No	No	0	7	8
9	R:R:I47	R:R:P91	5.08	No	No	0	7	9
10	R:R:F48	R:R:L52	12.18	No	No	0	4	4
11	R:R:A50	R:R:S86	3.42	No	No	0	8	8
12	R:R:A50	R:R:L394	3.15	No	Yes	0	8	7
13	R:R:V51	R:R:V87	3.21	No	No	0	7	6
14	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
15	R:R:D82	R:R:N54	5.39	Yes	Yes	0	9	9
16	R:R:L83	R:R:N54	8.24	No	Yes	0	8	9
17	R:R:N54	R:R:S86	4.47	Yes	No	0	9	8
18	R:R:N54	R:R:P397	3.26	Yes	No	0	9	9
19	R:R:C56	R:R:Y402	5.38	No	Yes	0	8	6
20	R:R:A79	R:R:V57	3.39	No	No	0	9	9
21	R:R:A401	R:R:V57	3.39	No	No	0	8	9
22	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
23	R:R:A60	R:R:F411	4.16	No	No	0	8	8
24	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
25	R:R:A410	R:R:E64	4.53	No	No	0	8	7
26	R:R:E64	R:R:K413	10.8	No	No	0	7	6
27	R:R:Q68	R:R:R65	15.19	No	No	0	8	7
28	R:R:D406	R:R:L67	4.07	No	Yes	0	7	8
29	R:R:F407	R:R:L67	4.87	Yes	Yes	0	8	8
30	R:R:A410	R:R:L67	4.73	No	Yes	0	8	8
31	R:R:N69	R:R:N72	12.26	No	No	0	8	9
32	R:R:P150	R:R:V70	5.3	No	No	0	5	7
33	R:R:I75	R:R:N72	5.66	No	No	0	8	9
34	R:R:F407	R:R:N72	7.25	Yes	No	0	8	9
35	R:R:D133	R:R:L74	4.07	No	No	0	9	8
36	R:R:A153	R:R:L74	3.15	No	No	0	7	8
37	R:R:L156	R:R:L74	4.15	No	No	0	6	8
38	R:R:H126	R:R:S77	6.97	Yes	No	1	8	9
39	R:R:I157	R:R:S77	9.29	No	No	1	8	9
40	R:R:D82	R:R:L78	6.79	Yes	Yes	1	9	9
41	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
42	R:R:L78	R:R:N396	9.61	Yes	No	1	9	9
43	R:R:L78	R:R:Y400	4.69	Yes	Yes	0	9	9
44	R:R:S122	R:R:T81	6.4	No	Yes	1	8	9
45	R:R:H126	R:R:T81	9.58	Yes	Yes	1	8	9
46	R:R:T81	R:R:W161	8.49	Yes	Yes	1	9	9
47	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
48	R:R:D82	R:R:S393	8.83	Yes	No	0	9	9
49	R:R:D82	R:R:N396	12.12	Yes	No	1	9	9
50	R:R:C119	R:R:M84	4.86	No	No	0	7	7
51	R:R:V85	R:R:V89	3.21	No	No	0	8	8
52	R:R:S393	R:R:V85	8.08	No	No	0	9	8
53	R:R:F112	R:R:V89	5.24	No	No	0	6	8
54	R:R:D116	R:R:V89	8.76	Yes	No	0	8	8
55	R:R:L90	R:R:W387	4.56	No	Yes	1	8	8
56	R:R:L90	R:R:Y390	7.03	No	Yes	1	8	8
57	R:R:M92	R:R:P91	8.39	No	No	0	6	9
58	R:R:F112	R:R:M92	7.46	No	No	0	6	6
59	R:R:A93	R:R:Y390	4	No	Yes	1	7	8
60	L:L:?1	R:R:A93	3.99	Yes	No	1	0	7
61	R:R:L95	R:R:L99	4.15	No	No	0	6	5
62	R:R:L104	R:R:L95	6.92	No	No	0	7	6
63	R:R:W102	R:R:Y96	7.72	Yes	Yes	1	9	6
64	R:R:C187	R:R:Y96	4.03	Yes	Yes	1	9	6
65	L:L:?1	R:R:Y96	5.2	Yes	Yes	1	0	6
66	R:R:Q97	R:R:W387	3.29	No	Yes	0	7	8
67	R:R:D185	R:R:K101	8.3	No	No	0	4	5
68	R:R:L104	R:R:W102	9.11	No	Yes	0	7	9
69	R:R:T108	R:R:W102	3.64	No	Yes	0	6	9
70	R:R:C109	R:R:W102	7.84	No	Yes	1	9	9
71	R:R:C187	R:R:W102	13.06	Yes	Yes	1	9	9
72	R:R:G105	R:R:T108	3.64	No	No	0	7	6
73	R:R:D110	R:R:V107	4.38	No	No	0	7	4
74	R:R:C109	R:R:C187	7.28	No	Yes	1	9	9
75	R:R:D110	R:R:L111	8.14	No	No	0	7	5
76	R:R:D110	R:R:M172	4.16	No	No	0	7	6
77	R:R:F112	R:R:L115	8.53	No	No	0	6	5
78	L:L:?1	R:R:I113	9.04	Yes	No	0	0	7
79	R:R:A114	R:R:S168	3.42	No	No	0	7	8
80	R:R:A114	R:R:M172	3.22	No	No	0	7	6
81	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
82	R:R:D116	R:R:Y390	11.49	Yes	Yes	1	8	8
83	L:L:?1	R:R:D116	17.2	Yes	Yes	1	0	8
84	R:R:S168	R:R:V117	3.23	No	No	0	8	8
85	L:L:?1	R:R:V117	8.49	Yes	No	0	0	8
86	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
87	R:R:L118	R:R:S168	4.5	No	No	0	6	8
88	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
89	L:L:?1	R:R:C120	5.03	Yes	No	1	0	7
90	R:R:A203	R:R:T121	3.36	No	No	0	8	8
91	R:R:H126	R:R:S122	6.97	Yes	No	1	8	8
92	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
93	R:R:I124	R:R:P207	3.39	No	Yes	0	8	9
94	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
95	R:R:I124	R:R:W358	15.27	No	Yes	1	8	8
96	R:R:T160	R:R:W125	3.64	No	No	0	8	7
97	R:R:I163	R:R:W125	29.36	No	No	0	5	7
98	R:R:P207	R:R:W125	13.51	Yes	No	0	9	7
99	R:R:H126	R:R:I157	3.98	Yes	No	1	8	8
100	R:R:H126	R:R:T160	12.32	Yes	No	1	8	8
101	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
102	R:R:L127	R:R:M211	4.24	No	Yes	1	8	9
103	R:R:F354	R:R:L127	3.65	Yes	No	1	9	8
104	R:R:L127	R:R:Y400	8.21	No	Yes	0	8	9
105	R:R:C128	R:R:P207	3.77	No	Yes	0	7	9
106	R:R:C128	R:R:M211	4.86	No	Yes	0	7	9
107	R:R:A129	R:R:L156	4.73	No	No	0	8	6
108	R:R:I130	R:R:R134	6.26	No	No	0	9	9
109	R:R:I130	R:R:Y400	7.25	No	Yes	0	9	9
110	R:R:A131	R:R:L214	3.15	No	No	0	9	7
111	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
112	R:R:L132	R:R:W136	14.81	No	No	0	6	5
113	R:R:D133	R:R:R148	5.96	No	Yes	2	9	8
114	R:R:D133	R:R:R152	7.15	No	Yes	2	9	7
115	R:R:R134	R:R:Y215	6.17	No	Yes	0	9	9
116	R:R:W136	R:R:Y135	4.82	No	Yes	0	5	9
117	R:R:T139	R:R:Y135	8.74	No	Yes	0	8	9
118	R:R:L214	R:R:Y135	4.69	No	Yes	0	7	9
119	R:R:R217	R:R:Y135	5.14	No	Yes	0	7	9
120	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
121	R:R:R152	R:R:W136	11	Yes	No	0	7	5
122	R:R:D140	R:R:P141	3.22	No	No	0	7	8
123	R:R:D140	R:R:D143	6.65	No	No	0	7	6
124	R:R:I142	R:R:N146	4.25	No	No	0	6	5
125	R:R:D143	R:R:R152	7.15	No	Yes	0	6	7
126	R:R:V145	R:R:Y144	3.79	No	No	0	6	8
127	R:R:R148	R:R:Y144	14.4	Yes	No	0	8	8
128	R:R:R148	R:R:R152	8.53	Yes	Yes	2	8	7
129	R:R:R151	R:R:T149	5.17	No	No	0	6	8
130	R:R:T160	R:R:W161	3.64	No	Yes	1	8	9
131	R:R:F165	R:R:I169	7.54	No	No	0	5	6
132	R:R:I167	R:R:Y198	4.84	No	No	0	8	5
133	R:R:I169	R:R:P170	3.39	No	No	0	6	8
134	R:R:P170	R:R:P171	5.84	No	No	0	8	7
135	R:R:P170	R:R:W175	5.4	No	Yes	0	8	6
136	R:R:P171	R:R:S190	3.56	No	No	0	7	6
137	R:R:P171	R:R:Y195	19.47	No	No	0	7	8
138	R:R:R176	R:R:W175	9	No	Yes	0	6	6
139	R:R:D192	R:R:W175	3.35	No	Yes	0	6	6
140	R:R:G194	R:R:W175	4.22	No	Yes	0	5	6
141	R:R:W175	R:R:Y195	6.75	Yes	No	0	6	8
142	R:R:W175	R:R:Y198	11.58	Yes	No	0	6	5
143	R:R:H193	R:R:R176	5.64	No	No	0	4	6
144	R:R:P178	R:R:T177	3.5	No	No	0	5	5
145	R:R:D180	R:R:R181	10.72	No	No	0	4	4
146	R:R:K191	R:R:R181	16.09	No	No	0	5	4
147	R:R:D183	R:R:P184	4.83	No	No	0	1	1
148	L:L:?1	R:R:C187	7.04	Yes	Yes	1	0	9
149	L:L:?1	R:R:I189	6.33	Yes	No	0	0	6
150	R:R:D192	R:R:S190	7.36	No	No	0	6	6
151	R:R:K191	R:R:P369	5.02	No	No	0	5	7
152	R:R:E372	R:R:K191	10.8	No	No	0	3	5
153	R:R:F370	R:R:H193	4.53	Yes	No	0	5	4
154	R:R:S199	R:R:Y195	15.26	No	No	0	8	8
155	R:R:P369	R:R:T196	10.49	No	No	0	7	7
156	R:R:F201	R:R:I197	3.77	No	No	0	5	7
157	R:R:F370	R:R:I197	5.02	Yes	No	0	5	7
158	R:R:T200	R:R:Y205	8.74	No	Yes	0	7	7
159	R:R:F362	R:R:T200	3.89	Yes	No	0	7	7
160	R:R:L366	R:R:T200	8.84	No	No	0	7	7
161	R:R:F201	R:R:Y205	6.19	No	Yes	0	5	7
162	R:R:F204	R:R:Y205	5.16	Yes	Yes	0	8	7
163	R:R:F204	R:R:L208	7.31	Yes	No	0	8	7
164	R:R:F204	R:R:F354	6.43	Yes	Yes	0	8	9
165	R:R:F204	R:R:L359	4.87	Yes	No	0	8	7
166	R:R:F204	R:R:F362	20.36	Yes	Yes	0	8	7
167	R:R:I363	R:R:Y205	4.84	No	Yes	0	7	7
168	R:R:I206	R:R:P207	3.39	No	Yes	0	6	9
169	R:R:M211	R:R:Y215	3.59	Yes	Yes	1	9	9
170	R:R:M211	R:R:M351	4.33	Yes	No	1	9	8
171	R:R:F354	R:R:M211	6.22	Yes	Yes	1	9	9
172	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
173	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
174	R:R:M351	R:R:Y215	3.59	No	Yes	1	8	9
175	R:R:F219	R:R:V344	3.93	No	No	0	6	8
176	R:R:F219	R:R:L347	3.65	No	No	0	6	8
177	R:R:R225	R:R:T229	5.17	No	No	0	7	4
178	R:R:I226	R:R:R339	6.26	Yes	No	0	6	7
179	R:R:K231	R:R:R227	8.66	No	No	0	3	6
180	R:R:E326	R:R:E330	5.07	No	No	0	3	4
181	R:R:E330	R:R:R333	11.63	No	No	0	4	4
182	R:R:K332	R:R:M335	4.32	No	No	0	6	4
183	R:R:K334	R:R:R333	8.66	No	No	0	5	4
184	R:R:M335	R:R:R339	6.2	No	No	0	4	7
185	R:R:K342	R:R:K345	8.62	No	No	0	8	7
186	R:R:I349	R:R:K345	4.36	No	No	0	7	7
187	R:R:I350	R:R:Y400	3.63	No	Yes	0	8	9
188	R:R:I399	R:R:T353	6.08	No	No	0	8	7
189	R:R:F354	R:R:W358	4.01	Yes	Yes	1	9	8
190	R:R:I355	R:R:L359	4.28	No	No	0	7	7
191	R:R:C357	R:R:W358	5.22	No	Yes	1	8	8
192	R:R:C357	R:R:N392	7.87	No	No	1	8	9
193	R:R:F361	R:R:W358	4.01	Yes	Yes	1	8	8
194	R:R:F362	R:R:W358	7.02	Yes	Yes	1	7	8
195	R:R:G389	R:R:W358	5.63	No	Yes	0	8	8
196	R:R:N392	R:R:W358	13.56	No	Yes	1	9	8
197	R:R:L359	R:R:P360	3.28	No	No	0	7	9
198	R:R:I385	R:R:P360	5.08	No	No	0	6	9
199	R:R:F361	R:R:F362	13.93	Yes	Yes	1	8	7
200	L:L:?1	R:R:F361	16.2	Yes	Yes	1	0	8
201	L:L:?1	R:R:F362	7.72	Yes	Yes	1	0	7
202	R:R:F370	R:R:L366	4.87	Yes	No	0	5	7
203	R:R:C375	R:R:L368	3.17	No	Yes	0	4	4
204	R:R:S373	R:R:S374	3.26	No	No	0	3	5
205	R:R:M377	R:R:P378	5.03	No	No	0	4	7
206	R:R:G382	R:R:M377	3.49	No	No	0	4	4
207	L:L:?1	R:R:N386	4.35	Yes	No	0	0	7
208	R:R:W387	R:R:Y390	4.82	Yes	Yes	1	8	8
209	L:L:?1	R:R:Y390	10.4	Yes	Yes	1	0	8
210	R:R:N392	R:R:N396	12.26	No	No	1	9	9
211	R:R:I399	R:R:Y400	6.04	No	Yes	0	8	9
212	R:R:A401	R:R:F407	4.16	No	Yes	0	8	8
213	R:R:F411	R:R:Y402	5.16	No	Yes	0	8	6
214	R:R:D406	R:R:N404	5.39	No	No	0	7	9
215	R:R:F407	R:R:N404	3.62	Yes	No	0	8	9
216	R:R:K405	R:R:Q408	8.14	No	No	0	6	9
217	R:R:F407	R:R:F411	4.29	Yes	No	0	8	8
218	R:R:A186	R:R:D183	3.09	No	No	0	4	1
219	R:R:I363	R:R:V367	3.07	No	No	0	7	6
220	R:R:K332	R:R:V233	3.04	No	No	0	6	4
221	L:L:?1	R:R:A203	2.99	Yes	No	0	0	8
222	R:R:L41	R:R:V37	2.98	No	No	0	4	5
223	R:R:L83	R:R:V87	2.98	No	No	0	8	6
224	R:R:L368	R:R:V364	2.98	Yes	No	0	4	6
225	R:R:N146	R:R:V145	2.96	No	No	0	5	6
226	R:R:L43	R:R:T39	2.95	Yes	No	0	7	5
227	R:R:L347	R:R:T343	2.95	No	No	0	8	8
228	R:R:I349	R:R:I399	2.94	No	No	0	7	8
229	R:R:I384	R:R:L388	2.85	No	No	0	4	8
230	R:R:L88	R:R:M84	2.83	No	No	0	6	7
231	R:R:L212	R:R:M351	2.83	No	No	0	6	8
232	R:R:L368	R:R:M377	2.83	Yes	No	0	4	4
233	R:R:K101	R:R:N100	2.8	No	No	0	5	5
234	R:R:K147	R:R:N146	2.8	No	No	0	5	5
235	R:R:K332	R:R:N328	2.8	No	No	0	6	3
236	R:R:L162	R:R:L166	2.77	No	No	0	5	5
237	R:R:L210	R:R:L214	2.77	No	No	0	7	7
238	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
239	R:R:L394	R:R:L395	2.77	Yes	No	0	7	6
240	R:R:E340	R:R:I226	2.73	No	Yes	0	8	6
241	R:R:A153	R:R:Y73	2.67	No	No	0	7	6
242	R:R:F370	R:R:T196	2.59	Yes	No	0	5	7
243	R:R:L166	R:R:Y198	2.34	No	No	0	5	5
244	R:R:G174	R:R:P178	2.03	No	No	0	5	5
245	R:R:A79	R:R:G76	1.95	No	No	0	9	6
246	R:R:A401	R:R:P397	1.87	No	No	0	8	9
247	R:R:G164	R:R:T121	1.82	No	No	0	8	8
248	R:R:G202	R:R:I167	1.76	No	No	0	5	8
249	R:R:P150	R:R:T149	1.75	No	No	0	5	8
250	R:R:C371	R:R:S374	1.72	No	No	0	5	5
251	R:R:G53	R:R:L52	1.71	No	No	0	9	4
252	R:R:C119	R:R:V85	1.71	No	No	0	7	8
253	R:R:C371	R:R:V367	1.71	No	No	0	5	6
254	R:R:A153	R:R:V70	1.7	No	No	0	7	7
255	R:R:A336	R:R:V230	1.7	No	No	0	5	3
256	R:R:A186	R:R:T188	1.68	No	No	0	4	5
257	R:R:A222	R:R:T343	1.68	No	No	0	8	8
258	R:R:G105	R:R:Q106	1.64	No	No	0	7	4
259	R:R:L368	R:R:P369	1.64	Yes	No	0	4	7
260	R:R:L381	R:R:P378	1.64	No	No	0	6	7
261	R:R:S40	R:R:V98	1.62	No	No	0	5	6
262	R:R:A336	R:R:I226	1.62	No	Yes	0	5	6
263	R:R:V58	R:R:V80	1.6	No	No	0	7	7
264	R:R:T39	R:R:V98	1.59	No	No	0	5	6
265	R:R:C49	R:R:L394	1.59	No	Yes	0	5	7
266	R:R:T81	R:R:V80	1.59	Yes	No	0	9	7
267	R:R:T229	R:R:V230	1.59	No	No	0	4	3
268	R:R:A71	R:R:N69	1.56	No	No	0	8	8
269	R:R:A329	R:R:N328	1.56	No	No	0	5	3
270	R:R:A383	R:R:Q97	1.52	No	No	0	6	7
271	R:R:I226	R:R:T343	1.52	Yes	No	0	6	8
272	R:R:I350	R:R:T346	1.52	No	No	0	8	8
273	R:R:F219	R:R:G216	1.51	No	No	0	6	3
274	R:R:L46	R:R:S391	1.5	No	No	0	7	5
275	R:R:L67	R:R:S66	1.5	Yes	No	0	8	6
276	R:R:K101	R:R:T103	1.5	No	No	0	5	5
277	R:R:L159	R:R:S158	1.5	No	No	0	3	5
278	R:R:G216	R:R:R220	1.5	No	No	0	3	5
279	R:R:L210	R:R:V213	1.49	No	No	0	7	5
280	R:R:L395	R:R:V398	1.49	No	No	0	6	6
281	R:R:L42	R:R:T45	1.47	No	No	0	5	4
282	R:R:L99	R:R:T103	1.47	No	No	0	5	5
283	R:R:L104	R:R:T103	1.47	No	No	0	7	5
284	R:R:L380	R:R:T379	1.47	No	No	0	3	2
285	R:R:K228	R:R:K232	1.44	No	No	0	5	4
286	R:R:L173	R:R:M172	1.41	No	No	0	6	6
287	R:R:E179	R:R:T177	1.41	No	No	0	3	5
288	R:R:L42	R:R:L43	1.38	No	Yes	0	5	7
289	R:R:L394	R:R:L46	1.38	Yes	No	0	7	7
290	R:R:A137	R:R:R148	1.38	No	Yes	0	8	8
291	R:R:L159	R:R:L162	1.38	No	No	0	3	5
292	R:R:A331	R:R:R327	1.38	No	No	0	5	3
293	R:R:L380	R:R:L381	1.38	No	No	0	3	6
294	R:R:N325	R:R:N328	1.36	No	No	0	5	3
295	R:R:A186	R:R:Y96	1.33	No	Yes	0	4	6
296	R:R:D183	R:R:D185	1.33	No	No	0	1	4
297	R:R:E340	R:R:L337	1.33	No	No	0	8	5
298	R:R:R341	R:R:V344	1.31	No	No	0	6	8
299	R:R:D180	R:R:E179	1.3	No	No	0	4	3
300	R:R:L337	R:R:R333	1.21	No	No	0	5	4
301	R:R:E340	R:R:R223	1.16	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L43	4.2575	4	0	7
2	R:R:N54	5.34	4	0	9
3	R:R:L67	3.7925	4	0	8
4	R:R:L78	7.2	4	1	9
5	R:R:T81	6.515	4	1	9
6	R:R:D82	7.804	5	1	9
7	R:R:Y96	4.57	4	1	6
8	R:R:W102	8.274	5	1	9
9	R:R:D116	10.53	4	1	8
10	R:R:H126	7.54571	7	1	8
11	R:R:Y135	5.404	5	0	9
12	R:R:R148	7.5675	4	2	8
13	R:R:R152	8.4575	4	2	7
14	R:R:W161	8.328	5	1	9
15	R:R:W175	6.71667	6	0	6
16	R:R:C187	7.8525	4	1	9
17	R:R:F204	8.826	5	0	8
18	R:R:Y205	6.2325	4	0	7
19	R:R:P207	6.015	4	0	9
20	R:R:M211	4.648	5	1	9
21	R:R:Y215	4.72333	6	1	9
22	R:R:I226	3.0325	4	0	6
23	R:R:F354	5.066	5	1	9
24	R:R:W358	7.4925	8	1	8
25	R:R:F361	9.2275	4	1	8
26	R:R:F362	10.584	5	1	7
27	R:R:L368	2.655	4	0	4
28	R:R:F370	4.2525	4	0	5
29	R:R:W387	5.16	4	1	8
30	R:R:Y390	7.548	5	1	8
31	R:R:L394	2.2225	4	0	7
32	R:R:Y400	5.964	5	0	9
33	R:R:Y402	4.985	4	0	6
34	R:R:F407	4.86833	6	0	8
35	L:L:?1	7.99846	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L43	R:R:T39	11.1044	2.95	Yes	No	0	7	5
2	R:R:L43	R:R:W387	18.2802	7.97	Yes	Yes	0	7	8
3	R:R:A401	R:R:V57	11.5567	3.39	No	No	0	8	9
4	R:R:A401	R:R:P397	35.6499	1.87	No	No	0	8	9
5	R:R:N54	R:R:P397	36.9976	3.26	Yes	No	0	9	9
6	R:R:D82	R:R:N54	52.7	5.39	Yes	Yes	0	9	9
7	R:R:D82	R:R:S393	11.6471	8.83	Yes	No	0	9	9
8	R:R:S393	R:R:V85	11.1828	8.08	No	No	0	9	8
9	R:R:V85	R:R:V89	11.4843	3.21	No	No	0	8	8
10	R:R:D116	R:R:V89	12.9165	8.76	Yes	No	0	8	8
11	R:R:W387	R:R:Y390	23.3003	4.82	Yes	Yes	1	8	8
12	R:R:A50	R:R:S86	10.3597	3.42	No	No	0	8	8
13	R:R:N54	R:R:S86	11.816	4.47	Yes	No	0	9	8
14	R:R:A401	R:R:F407	22.9897	4.16	No	Yes	0	8	8
15	R:R:C120	R:R:W358	29.2701	5.22	No	Yes	1	7	8
16	R:R:F354	R:R:W358	63.135	4.01	Yes	Yes	1	9	8
17	R:R:F354	R:R:M211	92.5528	6.22	Yes	Yes	1	9	9
18	R:R:M211	R:R:Y215	100	3.59	Yes	Yes	1	9	9
19	R:R:I218	R:R:Y215	53.0708	3.63	No	Yes	0	9	9
20	R:R:I218	R:R:Y135	51.1834	3.63	No	Yes	0	9	9
21	R:R:W136	R:R:Y135	45.7352	4.82	No	Yes	0	5	9
22	R:R:R152	R:R:W136	41.8669	11	Yes	No	0	7	5
23	R:R:D133	R:R:R152	20.1375	7.15	No	Yes	2	9	7
24	R:R:D133	R:R:L74	18.3405	4.07	No	No	0	9	8
25	R:R:A153	R:R:L74	12.2803	3.15	No	No	0	7	8
26	L:L:?1	R:R:Y390	24.5877	10.4	Yes	Yes	1	0	8
27	L:L:?1	R:R:C120	22.0973	5.03	Yes	No	1	0	7
28	L:L:?1	R:R:F361	22.1636	16.2	Yes	Yes	1	0	8
29	R:R:F361	R:R:W358	22.5375	4.01	Yes	Yes	1	8	8
30	L:L:?1	R:R:F362	52.3774	7.72	Yes	Yes	1	0	7
31	R:R:F362	R:R:W358	42.7081	7.02	Yes	Yes	1	7	8
32	R:R:F204	R:R:F362	30.4489	20.36	Yes	Yes	0	8	7
33	R:R:F204	R:R:F354	50.3181	6.43	Yes	Yes	0	8	9
34	R:R:S168	R:R:V117	11.632	3.23	No	No	0	8	8
35	L:L:?1	R:R:V117	13.218	8.49	Yes	No	0	0	8
36	R:R:D82	R:R:L78	23.2611	6.79	Yes	Yes	1	9	9
37	R:R:N392	R:R:W358	29.7585	13.56	No	Yes	1	9	8
38	R:R:N392	R:R:N396	29.0168	12.26	No	No	1	9	9
39	R:R:F354	R:R:L127	15.7144	3.65	Yes	No	1	9	8
40	R:R:L127	R:R:Y400	26.6711	8.21	No	Yes	0	8	9
41	L:L:?1	R:R:Y96	35.3605	5.2	Yes	Yes	1	0	6
42	R:R:W102	R:R:Y96	20.6802	7.72	Yes	Yes	1	9	6
43	R:R:L104	R:R:W102	26.3304	9.11	No	Yes	0	7	9
44	L:L:?1	R:R:C187	24.1716	7.04	Yes	Yes	1	0	9
45	R:R:C187	R:R:W102	20.5596	13.06	Yes	Yes	1	9	9
46	R:R:L104	R:R:T103	15.0782	1.47	No	No	0	7	5
47	R:R:A186	R:R:Y96	13.23	1.33	No	Yes	0	4	6
48	R:R:T108	R:R:W102	11.3486	3.64	No	Yes	0	6	9
49	R:R:I130	R:R:Y400	13.2149	7.25	No	Yes	0	9	9
50	R:R:R134	R:R:Y215	13.1426	6.17	No	Yes	0	9	9
51	R:R:R148	R:R:R152	14.0953	8.53	Yes	Yes	2	8	7
52	R:R:R148	R:R:Y144	10.2481	14.4	Yes	No	0	8	8
53	R:R:R176	R:R:W175	27.3495	9	No	Yes	0	6	6
54	R:R:H193	R:R:R176	28.8118	5.64	No	No	0	4	6
55	R:R:F370	R:R:H193	30.268	4.53	Yes	No	0	5	4
56	R:R:F370	R:R:L366	47.7071	4.87	Yes	No	0	5	7
57	R:R:L366	R:R:T200	48.7653	8.84	No	No	0	7	7
58	R:R:F362	R:R:T200	41.9212	3.89	Yes	No	0	7	7
59	R:R:W175	R:R:Y198	10.8662	11.58	Yes	No	0	6	5
60	R:R:F370	R:R:T196	28.7153	2.59	Yes	No	0	5	7
61	R:R:P369	R:R:T196	27.253	10.49	No	No	0	7	7
62	R:R:K191	R:R:P369	12.3948	5.02	No	No	0	5	7
63	R:R:F201	R:R:Y205	13.1938	6.19	No	Yes	0	5	7
64	R:R:T200	R:R:Y205	14.1225	8.74	No	Yes	0	7	7
65	R:R:F204	R:R:Y205	27.5726	5.16	Yes	Yes	0	8	7
66	R:R:F201	R:R:I197	11.9607	3.77	No	No	0	5	7
67	R:R:F370	R:R:I197	11.1165	5.02	Yes	No	0	5	7
68	R:R:L347	R:R:Y215	53.0678	4.69	No	Yes	0	8	9
69	R:R:F219	R:R:L347	10.2481	3.65	No	No	0	6	8
70	R:R:L347	R:R:T343	41.5443	2.95	No	No	0	8	8
71	R:R:I226	R:R:T343	37.8056	1.52	Yes	No	0	6	8
72	R:R:I226	R:R:R339	14.2943	6.26	Yes	No	0	6	7
73	R:R:E340	R:R:L337	10.2481	1.33	No	No	0	8	5
74	R:R:E340	R:R:I226	14.2943	2.73	No	Yes	0	8	6
75	R:R:M335	R:R:R339	12.2773	6.2	No	No	0	4	7
76	R:R:K332	R:R:M335	10.2451	4.32	No	No	0	6	4
77	R:R:L368	R:R:P369	13.821	1.64	Yes	No	0	4	7
78	R:R:D82	R:R:N396	26.252	12.12	Yes	No	1	9	9
79	R:R:L78	R:R:Y400	25.248	4.69	Yes	Yes	0	9	9
80	R:R:I130	R:R:R134	11.819	6.26	No	No	0	9	9
81	R:R:L127	R:R:M211	12.3918	4.24	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D116	R:R:V89	8.76	1	Yes	No	8	8	1	2
R:R:L90	R:R:W387	4.56	1	No	Yes	8	8	2	2
R:R:L90	R:R:Y390	7.03	1	No	Yes	8	8	2	1
R:R:A93	R:R:Y390	4	1	No	Yes	7	8	1	1
L:L:?1	R:R:A93	3.99	1	Yes	No	0	7	0	1
R:R:W102	R:R:Y96	7.72	1	Yes	Yes	9	6	2	1
R:R:C187	R:R:Y96	4.03	1	Yes	Yes	9	6	1	1
L:L:?1	R:R:Y96	5.2	1	Yes	Yes	0	6	0	1
R:R:C109	R:R:W102	7.84	1	No	Yes	9	9	2	2
R:R:C187	R:R:W102	13.06	1	Yes	Yes	9	9	1	2
R:R:C109	R:R:C187	7.28	1	No	Yes	9	9	2	1
L:L:?1	R:R:I113	9.04	1	Yes	No	0	7	0	1
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	11.49	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D116	17.2	1	Yes	Yes	0	8	0	1
R:R:S168	R:R:V117	3.23	0	No	No	8	8	2	1
L:L:?1	R:R:V117	8.49	1	Yes	No	0	8	0	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	2
L:L:?1	R:R:C120	5.03	1	Yes	No	0	7	0	1
R:R:A203	R:R:T121	3.36	0	No	No	8	8	1	2
L:L:?1	R:R:C187	7.04	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I189	6.33	1	Yes	No	0	6	0	1
R:R:F362	R:R:T200	3.89	1	Yes	No	7	7	1	2
R:R:F204	R:R:F362	20.36	0	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	4.01	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	7.02	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	13.93	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:F361	16.2	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	7.72	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	4.35	1	Yes	No	0	7	0	1
R:R:W387	R:R:Y390	4.82	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:Y390	10.4	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A203	2.99	1	Yes	No	0	8	0	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1
R:R:A186	R:R:Y96	1.33	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9GL2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	271
Number of Links	301
Number of Hubs	35
Number of Links mediated by Hubs	142
Number of Communities	2
Number of Nodes involved in Communities	35
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	76139
Length Of Smallest Path	3
Average Path Length	13.2032
Length of Longest Path	28
Minimum Path Strength	1.23333
Average Path Strength	5.9037
Maximum Path Strength	21.435
Minimum Path Correlation	0.7
Average Path Correlation	0.941312
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	54.9724
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0172
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ZKV
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ZKV
Name	Befiradol
Synonyms	(3-chloro-4-fluorophenyl)(4-fluoro-4-((((5-methylpyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone Befiradol (2E)-2-butenedioate 4-piperidinemethanamine
Identifier
Formula	C20 H22 Cl F2 N3 O
Molecular Weight	393.858
SMILES
PubChem	9865384
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	51
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9GL2_nogp_Chain_R S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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