psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L41	R:R:V37	2.98	No	No	0	4	5
2	R:R:L43	R:R:T39	2.95	No	No	0	7	5
3	R:R:A94	R:R:L43	4.73	No	No	0	7	7
4	R:R:L43	R:R:W387	10.25	No	No	0	7	8
5	R:R:I47	R:R:L90	4.28	No	Yes	0	7	8
6	R:R:A50	R:R:S86	3.42	No	No	0	8	8
7	R:R:L83	R:R:V51	2.98	Yes	No	0	8	7
8	R:R:C56	R:R:L52	3.17	No	No	0	8	4
9	R:R:D82	R:R:N54	8.08	Yes	No	3	9	9
10	R:R:L83	R:R:N54	5.49	Yes	No	0	8	9
11	R:R:N54	R:R:P397	9.77	No	No	3	9	9
12	R:R:C56	R:R:Y402	4.03	No	Yes	0	8	6
13	R:R:I61	R:R:V57	3.07	No	Yes	0	8	9
14	R:R:A79	R:R:V57	3.39	No	Yes	0	9	9
15	R:R:A401	R:R:V57	3.39	No	Yes	0	8	9
16	R:R:V57	R:R:Y402	3.79	Yes	Yes	0	9	6
17	R:R:V58	R:R:V80	3.21	No	No	0	7	7
18	R:R:A60	R:R:F411	5.55	No	No	0	8	8
19	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
20	R:R:A410	R:R:E64	3.02	No	No	0	8	7
21	R:R:E64	R:R:K413	6.75	No	No	0	7	6
22	R:R:E64	R:R:I414	4.1	No	No	0	7	7
23	R:R:L67	R:R:N72	4.12	No	No	0	8	9
24	R:R:A410	R:R:L67	4.73	No	No	0	8	8
25	R:R:Q68	R:R:Y73	6.76	No	No	0	8	6
26	R:R:N69	R:R:N72	16.35	No	No	0	8	9
27	R:R:R148	R:R:V70	14.38	No	No	0	8	7
28	R:R:F407	R:R:N72	8.46	Yes	No	0	8	9
29	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
30	R:R:D133	R:R:L74	5.43	No	Yes	0	9	8
31	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
32	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
33	R:R:F407	R:R:I75	5.02	Yes	No	0	8	8
34	R:R:H126	R:R:S77	6.97	Yes	No	0	8	9
35	R:R:I157	R:R:S77	10.84	No	No	0	8	9
36	R:R:D82	R:R:L78	5.43	Yes	No	0	9	9
37	R:R:H126	R:R:L78	7.71	Yes	No	0	8	9
38	R:R:L78	R:R:Y400	3.52	No	Yes	0	9	9
39	R:R:H126	R:R:T81	10.95	Yes	No	0	8	9
40	R:R:T81	R:R:W161	7.28	No	Yes	0	9	9
41	R:R:D82	R:R:S123	4.42	Yes	No	0	9	9
42	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
43	R:R:D82	R:R:N396	4.04	Yes	No	0	9	9
44	R:R:D82	R:R:P397	3.22	Yes	No	3	9	9
45	R:R:L83	R:R:V87	2.98	Yes	No	0	8	6
46	R:R:M84	R:R:W161	3.49	No	Yes	0	7	9
47	R:R:S393	R:R:V85	3.23	No	No	0	9	8
48	R:R:L90	R:R:S86	3	Yes	No	0	8	8
49	R:R:L88	R:R:V87	2.98	No	No	0	6	6
50	R:R:D116	R:R:V89	5.84	Yes	No	1	8	8
51	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
52	R:R:L90	R:R:Y390	8.21	Yes	Yes	0	8	8
53	R:R:M92	R:R:T108	3.01	No	No	0	6	6
54	R:R:F112	R:R:M92	6.22	Yes	No	0	6	6
55	R:R:A93	R:R:Y390	4	No	Yes	0	7	8
56	R:R:L95	R:R:L99	5.54	No	No	0	6	5
57	R:R:W102	R:R:Y96	4.82	Yes	No	0	9	6
58	L:L:?1	R:R:Y96	16.55	Yes	No	0	0	6
59	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
60	R:R:Q97	R:R:W387	4.38	No	No	0	7	8
61	L:L:?1	R:R:Q97	5.12	Yes	No	0	0	7
62	R:R:L99	R:R:V98	2.98	No	No	0	5	6
63	R:R:L99	R:R:T103	2.95	No	No	0	5	5
64	R:R:K101	R:R:T103	3	No	No	0	5	5
65	R:R:D185	R:R:K101	4.15	No	No	0	4	5
66	R:R:L104	R:R:W102	6.83	No	Yes	2	7	9
67	R:R:T108	R:R:W102	6.06	No	Yes	2	6	9
68	R:R:C109	R:R:W102	6.53	No	Yes	2	9	9
69	R:R:F112	R:R:W102	4.01	Yes	Yes	0	6	9
70	R:R:C187	R:R:W102	9.14	No	Yes	2	9	9
71	R:R:L104	R:R:T103	2.95	No	No	0	7	5
72	R:R:L104	R:R:T108	7.37	No	No	2	7	6
73	R:R:C109	R:R:C187	7.28	No	No	2	9	9
74	R:R:D110	R:R:M172	9.7	No	No	0	7	6
75	R:R:L111	R:R:L115	4.15	No	No	0	5	5
76	R:R:F112	R:R:I113	3.77	Yes	Yes	0	6	7
77	L:L:?1	R:R:F112	6.25	Yes	Yes	0	0	6
78	R:R:C187	R:R:I113	3.27	No	Yes	0	9	7
79	R:R:I113	R:R:I189	4.42	Yes	No	0	7	6
80	R:R:C120	R:R:D116	3.11	No	Yes	1	7	8
81	R:R:D116	R:R:Y390	10.34	Yes	Yes	1	8	8
82	L:L:?1	R:R:D116	11.32	Yes	Yes	1	0	8
83	R:R:S168	R:R:V117	6.46	No	No	0	8	8
84	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
85	R:R:F165	R:R:L118	13.4	No	No	0	5	6
86	R:R:L118	R:R:S168	3	No	No	0	6	8
87	L:L:?1	R:R:C120	5.09	Yes	No	1	0	7
88	R:R:G164	R:R:T121	3.64	No	No	0	8	8
89	R:R:I167	R:R:T121	4.56	No	No	0	8	8
90	R:R:S122	R:R:W161	16.06	No	Yes	0	8	9
91	R:R:I124	R:R:P207	3.39	No	No	0	8	9
92	R:R:I124	R:R:W358	14.09	No	Yes	0	8	8
93	R:R:C128	R:R:W125	3.92	No	No	0	7	7
94	R:R:I163	R:R:W125	7.05	No	No	0	5	7
95	R:R:P207	R:R:W125	6.76	No	No	0	9	7
96	R:R:H126	R:R:T160	6.85	Yes	No	0	8	8
97	R:R:L127	R:R:N396	6.87	No	No	0	8	9
98	R:R:L127	R:R:Y400	7.03	No	Yes	0	8	9
99	R:R:C128	R:R:L210	3.17	No	No	0	7	7
100	R:R:A129	R:R:L156	3.15	No	No	0	8	6
101	R:R:I130	R:R:R134	3.76	No	No	4	9	9
102	R:R:I130	R:R:Y400	3.63	No	Yes	4	9	9
103	R:R:A131	R:R:L214	3.15	No	No	0	9	7
104	R:R:A131	R:R:Y215	4	No	Yes	0	9	9
105	R:R:L132	R:R:W136	17.08	No	No	0	6	5
106	R:R:L132	R:R:L214	4.15	No	No	0	6	7
107	R:R:D133	R:R:R148	10.72	No	No	0	9	8
108	R:R:R134	R:R:Y215	3.09	No	Yes	0	9	9
109	R:R:R134	R:R:Y400	4.12	No	Yes	4	9	9
110	R:R:T139	R:R:Y135	14.98	No	No	0	8	9
111	R:R:L214	R:R:Y135	5.86	No	No	0	7	9
112	R:R:R217	R:R:Y135	13.38	No	No	0	7	9
113	R:R:R152	R:R:W136	7	No	No	0	7	5
114	R:R:I138	R:R:I218	4.42	No	No	0	9	9
115	R:R:D140	R:R:P141	3.22	No	No	0	7	8
116	R:R:D140	R:R:D143	6.65	No	No	0	7	6
117	R:R:D143	R:R:K147	4.15	No	No	0	6	5
118	R:R:D143	R:R:R152	7.15	No	No	0	6	7
119	R:R:R148	R:R:Y144	13.38	No	No	0	8	8
120	R:R:N146	R:R:V145	4.43	No	No	0	5	6
121	R:R:P150	R:R:T149	5.25	No	No	0	5	8
122	R:R:T160	R:R:W161	4.85	No	Yes	0	8	9
123	R:R:I163	R:R:I167	2.94	No	No	0	5	8
124	R:R:F165	R:R:I169	3.77	No	No	0	5	6
125	R:R:I169	R:R:P170	3.39	No	No	0	6	8
126	R:R:P170	R:R:P171	5.84	No	No	0	8	7
127	R:R:P171	R:R:Y195	12.52	No	Yes	0	7	8
128	R:R:G174	R:R:L173	3.42	No	No	0	5	6
129	R:R:S190	R:R:W175	19.77	No	No	0	6	6
130	R:R:K191	R:R:T188	3	No	No	0	5	5
131	R:R:I189	R:R:Y195	3.63	No	Yes	0	6	8
132	R:R:S190	R:R:Y195	3.82	No	Yes	0	6	8
133	R:R:D192	R:R:G194	5.03	No	No	0	6	5
134	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
135	R:R:F370	R:R:H193	13.58	No	No	0	5	4
136	R:R:S199	R:R:Y195	3.82	No	Yes	0	8	8
137	R:R:P369	R:R:T196	6.99	No	No	0	7	7
138	R:R:F201	R:R:I197	7.54	No	No	0	5	7
139	L:L:?1	R:R:S199	4.82	Yes	No	0	0	8
140	R:R:T200	R:R:Y205	3.75	No	Yes	0	7	7
141	R:R:F201	R:R:Y205	5.16	No	Yes	0	5	7
142	L:L:?1	R:R:A203	3.03	Yes	No	0	0	8
143	R:R:F204	R:R:Y205	6.19	Yes	Yes	0	8	7
144	R:R:F204	R:R:L208	7.31	Yes	No	1	8	7
145	R:R:F204	R:R:F354	3.22	Yes	Yes	1	8	9
146	R:R:F204	R:R:L359	3.65	Yes	Yes	0	8	7
147	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
148	R:R:I363	R:R:Y205	4.84	No	Yes	0	7	7
149	R:R:L366	R:R:Y205	5.86	No	Yes	0	7	7
150	R:R:I206	R:R:P207	3.39	No	No	0	6	9
151	R:R:L208	R:R:L212	4.15	No	No	0	7	6
152	R:R:F354	R:R:L208	3.65	Yes	No	1	9	7
153	R:R:L209	R:R:V213	2.98	No	No	0	5	5
154	R:R:M211	R:R:Y215	5.99	No	Yes	0	9	9
155	R:R:F354	R:R:M211	3.73	Yes	No	0	9	9
156	R:R:R217	R:R:V213	5.23	No	No	0	7	5
157	R:R:I350	R:R:Y215	7.25	No	Yes	0	8	9
158	R:R:M351	R:R:Y215	4.79	No	Yes	0	8	9
159	R:R:F219	R:R:R223	3.21	Yes	No	0	6	7
160	R:R:F219	R:R:L347	3.65	Yes	Yes	0	6	8
161	R:R:R223	R:R:R227	7.46	No	No	0	7	6
162	R:R:E340	R:R:R223	8.14	No	No	0	8	7
163	R:R:F224	R:R:K228	6.2	No	No	0	6	5
164	R:R:K228	R:R:R225	4.95	No	No	0	5	7
165	R:R:I226	R:R:R339	3.76	No	No	0	6	7
166	R:R:A329	R:R:R333	4.15	No	No	0	5	4
167	R:R:E330	R:R:R333	10.47	No	No	0	4	4
168	R:R:K332	R:R:M335	4.32	No	No	0	6	4
169	R:R:M335	R:R:R339	12.41	No	No	0	4	7
170	R:R:L347	R:R:T343	2.95	Yes	No	0	8	8
171	R:R:L395	R:R:T353	2.95	No	No	0	6	7
172	R:R:I399	R:R:T353	4.56	No	No	0	8	7
173	R:R:F354	R:R:W358	5.01	Yes	Yes	0	9	8
174	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
175	R:R:C357	R:R:N392	9.45	No	No	0	8	9
176	R:R:F362	R:R:W358	5.01	Yes	Yes	0	7	8
177	R:R:G389	R:R:W358	7.04	No	Yes	0	8	8
178	R:R:N392	R:R:W358	11.3	No	Yes	0	9	8
179	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
180	R:R:I363	R:R:L359	4.28	No	Yes	0	7	7
181	R:R:F361	R:R:F362	11.79	Yes	Yes	1	8	7
182	R:R:F361	R:R:N386	3.62	Yes	No	0	8	7
183	L:L:?1	R:R:F361	18.75	Yes	Yes	1	0	8
184	L:L:?1	R:R:F362	6.25	Yes	Yes	1	0	7
185	R:R:L368	R:R:V364	2.98	Yes	No	0	4	6
186	R:R:I385	R:R:V364	3.07	No	No	0	6	6
187	R:R:C375	R:R:L368	3.17	No	Yes	0	4	4
188	R:R:L368	R:R:M377	7.07	Yes	No	0	4	4
189	R:R:F370	R:R:P369	4.33	No	No	0	5	7
190	R:R:L381	R:R:P378	4.93	No	No	0	6	7
191	R:R:I384	R:R:L380	4.28	No	No	0	4	3
192	R:R:I385	R:R:L381	5.71	No	No	0	6	6
193	R:R:W387	R:R:Y390	7.72	No	Yes	0	8	8
194	L:L:?1	R:R:Y390	4.51	Yes	Yes	1	0	8
195	R:R:N392	R:R:N396	13.62	No	No	0	9	9
196	R:R:F403	R:R:V398	3.93	No	No	0	8	6
197	R:R:A401	R:R:F407	8.32	No	Yes	0	8	8
198	R:R:F411	R:R:Y402	12.38	No	Yes	0	8	6
199	R:R:D406	R:R:N404	5.39	No	No	0	7	9
200	R:R:F407	R:R:N404	6.04	Yes	No	0	8	9
201	R:R:K405	R:R:Q408	4.07	No	No	0	6	9
202	R:R:I113	R:R:M172	2.92	Yes	No	0	7	6
203	R:R:I189	R:R:K191	2.91	No	No	0	6	5
204	R:R:I38	R:R:L42	2.85	No	No	0	3	5
205	R:R:I414	R:R:L63	2.85	No	No	0	7	6
206	R:R:I157	R:R:L74	2.85	No	Yes	0	8	8
207	R:R:I169	R:R:L173	2.85	No	No	0	6	6
208	R:R:I384	R:R:L388	2.85	No	No	0	4	8
209	R:R:G105	R:R:W102	2.81	No	Yes	0	7	9
210	R:R:L394	R:R:L46	2.77	No	No	0	7	7
211	R:R:L394	R:R:L395	2.77	No	No	0	7	6
212	R:R:A186	R:R:Y96	2.67	No	No	0	4	6
213	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
214	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
215	R:R:R151	R:R:T149	2.59	No	No	0	6	8
216	R:R:F361	R:R:I385	2.51	Yes	No	0	8	6
217	R:R:I399	R:R:Y400	2.42	No	Yes	0	8	9
218	R:R:L166	R:R:Y198	2.34	No	No	0	5	5
219	R:R:L347	R:R:Y215	2.34	Yes	Yes	0	8	9
220	R:R:A79	R:R:G76	1.95	No	No	0	9	6
221	R:R:C371	R:R:C375	1.82	No	No	0	5	4
222	R:R:P397	R:R:V57	1.77	No	Yes	0	9	9
223	R:R:P150	R:R:V70	1.77	No	No	0	5	7
224	R:R:G202	R:R:I167	1.76	No	No	0	5	8
225	R:R:G202	R:R:I206	1.76	No	No	0	5	6
226	R:R:G352	R:R:I355	1.76	No	No	0	6	7
227	R:R:G382	R:R:M377	1.75	No	No	0	4	4
228	R:R:G53	R:R:L52	1.71	No	No	0	9	4
229	R:R:C119	R:R:V85	1.71	No	No	0	7	8
230	R:R:A114	R:R:S168	1.71	No	No	0	7	8
231	R:R:G348	R:R:L347	1.71	No	Yes	0	7	8
232	R:R:C371	R:R:V367	1.71	No	No	0	5	6
233	R:R:G389	R:R:L388	1.71	No	No	0	8	8
234	R:R:A79	R:R:V58	1.7	No	No	0	9	7
235	R:R:C49	R:R:T45	1.69	No	No	0	5	4
236	R:R:A365	R:R:T200	1.68	No	No	0	8	7
237	R:R:A222	R:R:T343	1.68	No	No	0	8	8
238	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
239	R:R:L368	R:R:P369	1.64	Yes	No	0	4	7
240	R:R:S373	R:R:S374	1.63	No	No	0	3	5
241	R:R:S40	R:R:V98	1.62	No	No	0	5	6
242	R:R:A221	R:R:I138	1.62	No	No	0	6	9
243	R:R:A336	R:R:I226	1.62	No	No	0	5	6
244	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
245	R:R:A59	R:R:L63	1.58	No	No	0	5	6
246	R:R:P184	R:R:Q106	1.58	No	No	0	1	4
247	R:R:A71	R:R:N69	1.56	No	No	0	8	8
248	R:R:I138	R:R:T139	1.52	No	No	0	9	8
249	R:R:I226	R:R:T343	1.52	No	No	0	6	8
250	R:R:I350	R:R:T346	1.52	No	No	0	8	8
251	R:R:I349	R:R:T353	1.52	No	No	0	7	7
252	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
253	R:R:L41	R:R:S40	1.5	No	No	0	4	5
254	R:R:L67	R:R:S66	1.5	No	No	0	8	6
255	R:R:L115	R:R:V89	1.49	No	No	0	5	8
256	R:R:I349	R:R:K345	1.45	No	No	0	7	7
257	R:R:I142	R:R:N146	1.42	No	No	0	6	5
258	R:R:D140	R:R:I142	1.4	No	No	0	7	6
259	R:R:K147	R:R:N146	1.4	No	No	0	5	5
260	R:R:K405	R:R:N404	1.4	No	No	0	6	9
261	R:R:L159	R:R:L162	1.38	No	No	0	3	5
262	R:R:A338	R:R:R341	1.38	No	No	0	5	6
263	R:R:N325	R:R:N328	1.36	No	No	0	5	3
264	R:R:N409	R:R:Q408	1.32	No	No	0	6	9
265	R:R:S199	R:R:Y198	1.27	No	No	0	8	5
266	R:R:V398	R:R:Y402	1.26	No	Yes	0	6	6
267	R:R:F48	R:R:L52	1.22	No	No	0	4	4
268	R:R:R217	R:R:R220	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V57	3.082	5	0	9
2	R:R:L74	3.895	4	0	8
3	R:R:D82	4.935	6	3	9
4	R:R:L83	3.2575	4	0	8
5	R:R:L90	4.2825	4	0	8
6	R:R:W102	5.74286	7	2	9
7	R:R:F112	5.0625	4	0	6
8	R:R:I113	3.595	4	0	7
9	R:R:D116	7.6525	4	1	8
10	R:R:H126	8.12	4	0	8
11	R:R:W161	7.474	5	0	9
12	R:R:Y195	5.448	5	0	8
13	R:R:F204	8.146	5	1	8
14	R:R:Y205	5.16	5	0	7
15	R:R:Y215	4.57667	6	0	9
16	R:R:F219	2.7475	4	0	6
17	R:R:L347	2.6625	4	0	8
18	R:R:F354	3.9025	4	1	9
19	R:R:W358	8.49	5	0	8
20	R:R:L359	3.8725	4	0	7
21	R:R:F361	9.1675	4	1	8
22	R:R:F362	10.8525	4	1	7
23	R:R:L368	3.715	4	0	4
24	R:R:Y390	6.42833	6	1	8
25	R:R:Y400	4.144	5	4	9
26	R:R:Y402	5.365	4	0	6
27	R:R:F407	6.572	5	0	8
28	L:L:?1	8.169	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S40	R:R:V98	10.664	1.62	No	No	0	5	6
2	R:R:L99	R:R:V98	14.1981	2.98	No	No	0	5	6
3	R:R:L99	R:R:T103	21.2324	2.95	No	No	0	5	5
4	R:R:L104	R:R:T103	31.6995	2.95	No	No	0	7	5
5	R:R:L104	R:R:W102	35.0535	6.83	No	Yes	2	7	9
6	R:R:W102	R:R:Y96	24.0912	4.82	Yes	No	0	9	6
7	L:L:?1	R:R:Y96	26.933	16.55	Yes	No	0	0	6
8	R:R:L43	R:R:W387	10.2983	10.25	No	No	0	7	8
9	R:R:F112	R:R:W102	25.7062	4.01	Yes	Yes	0	6	9
10	L:L:?1	R:R:F112	38.5481	6.25	Yes	Yes	0	0	6
11	L:L:?1	R:R:Y390	23.5959	4.51	Yes	Yes	1	0	8
12	L:L:?1	R:R:F362	100	6.25	Yes	Yes	1	0	7
13	R:R:F362	R:R:W358	96.1339	5.01	Yes	Yes	0	7	8
14	R:R:N392	R:R:W358	80.9004	11.3	No	Yes	0	9	8
15	R:R:N392	R:R:N396	80.0113	13.62	No	No	0	9	9
16	R:R:D82	R:R:N396	73.247	4.04	Yes	No	0	9	9
17	R:R:V57	R:R:Y402	15.2392	3.79	Yes	Yes	0	9	6
18	R:R:P397	R:R:V57	75.4924	1.77	No	Yes	0	9	9
19	R:R:D82	R:R:P397	74.8565	3.22	Yes	No	3	9	9
20	R:R:I61	R:R:V57	29.0827	3.07	No	Yes	0	8	9
21	R:R:A401	R:R:V57	29.0827	3.39	No	Yes	0	8	9
22	R:R:F407	R:R:I61	27.6533	5.02	Yes	No	0	8	8
23	R:R:A401	R:R:F407	27.6533	8.32	No	Yes	0	8	8
24	R:R:A410	R:R:L67	18.8351	4.73	No	No	0	8	8
25	R:R:L67	R:R:N72	25.0253	4.12	No	No	0	8	9
26	R:R:F407	R:R:N72	34.2262	8.46	Yes	No	0	8	9
27	R:R:A410	R:R:E64	15.7231	3.02	No	No	0	8	7
28	R:R:D82	R:R:L78	53.0782	5.43	Yes	No	0	9	9
29	R:R:H126	R:R:L78	48.3174	7.71	Yes	No	0	8	9
30	R:R:H126	R:R:S77	28.3568	6.97	Yes	No	0	8	9
31	R:R:I157	R:R:S77	26.6685	10.84	No	No	0	8	9
32	R:R:I157	R:R:L74	24.969	2.85	No	Yes	0	8	8
33	R:R:D133	R:R:L74	18.0585	5.43	No	Yes	0	9	8
34	R:R:D133	R:R:R148	16.3028	10.72	No	No	0	9	8
35	R:R:R148	R:R:V70	10.9679	14.38	No	No	0	8	7
36	R:R:H126	R:R:T81	13.3652	10.95	Yes	No	0	8	9
37	L:L:?1	R:R:S199	25.0141	4.82	Yes	No	0	0	8
38	R:R:S199	R:R:Y195	20.6246	3.82	No	Yes	0	8	8
39	R:R:P171	R:R:Y195	13.4159	12.52	No	Yes	0	7	8
40	R:R:P170	R:R:P171	12.0034	5.84	No	No	0	8	7
41	R:R:I169	R:R:P170	11.7558	3.39	No	No	0	6	8
42	R:R:F165	R:R:I169	13.7141	3.77	No	No	0	5	6
43	R:R:F165	R:R:L118	14.4007	13.4	No	No	0	5	6
44	R:R:L118	R:R:W161	18.6325	5.69	No	Yes	0	6	9
45	R:R:F112	R:R:I113	12.3635	3.77	Yes	Yes	0	6	7
46	R:R:P207	R:R:W125	11.4688	6.76	No	No	0	9	7
47	R:R:I124	R:R:P207	21.2493	3.39	No	No	0	8	9
48	R:R:I124	R:R:W358	22.8137	14.09	No	Yes	0	8	8
49	R:R:H126	R:R:T160	13.3371	6.85	Yes	No	0	8	8
50	R:R:R134	R:R:Y215	32.9375	3.09	No	Yes	0	9	9
51	R:R:M211	R:R:Y215	58.8126	5.99	No	Yes	0	9	9
52	R:R:F354	R:R:M211	59.6849	3.73	Yes	No	0	9	9
53	R:R:F204	R:R:F354	38.1373	3.22	Yes	Yes	1	8	9
54	R:R:F204	R:R:F362	41.4969	20.36	Yes	Yes	1	8	7
55	R:R:F354	R:R:W358	39.9043	5.01	Yes	Yes	0	9	8
56	R:R:A131	R:R:Y215	43.8773	4	No	Yes	0	9	9
57	R:R:A131	R:R:L214	41.8908	3.15	No	No	0	9	7
58	R:R:L132	R:R:L214	21.4069	4.15	No	No	0	6	7
59	R:R:L132	R:R:W136	19.2966	17.08	No	No	0	6	5
60	R:R:L214	R:R:Y135	19.4935	5.86	No	No	0	7	9
61	R:R:R152	R:R:W136	17.1694	7	No	No	0	7	5
62	R:R:D143	R:R:R152	15.2335	7.15	No	No	0	6	7
63	R:R:L368	R:R:V364	18.2836	2.98	Yes	No	0	4	6
64	R:R:I385	R:R:V364	20.0506	3.07	No	No	0	6	6
65	R:R:F361	R:R:I385	25.2842	2.51	Yes	No	0	8	6
66	R:R:F204	R:R:Y205	16.4041	6.19	Yes	Yes	0	8	7
67	R:R:F204	R:R:L359	11.7783	3.65	Yes	Yes	0	8	7
68	R:R:F219	R:R:L347	12.8981	3.65	Yes	Yes	0	6	8
69	R:R:L347	R:R:Y215	31.3956	2.34	Yes	Yes	0	8	9
70	R:R:I226	R:R:T343	10.5346	1.52	No	No	0	6	8
71	R:R:L347	R:R:T343	14.8452	2.95	Yes	No	0	8	8
72	R:R:I399	R:R:Y400	11.4575	2.42	No	Yes	0	8	9
73	R:R:F407	R:R:N404	15.7231	6.04	Yes	No	0	8	9
74	R:R:L78	R:R:Y400	33.2921	3.52	No	Yes	0	9	9
75	R:R:T81	R:R:W161	11.964	7.28	No	Yes	0	9	9
76	R:R:T160	R:R:W161	11.9358	4.85	No	Yes	0	8	9
77	R:R:R134	R:R:Y400	30.5459	4.12	No	Yes	4	9	9
78	R:R:F361	R:R:F362	20.3433	11.79	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D116	R:R:V89	5.84	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	8.21	0	Yes	Yes	8	8	2	1
R:R:F112	R:R:M92	6.22	0	Yes	No	6	6	1	2
R:R:A93	R:R:Y390	4	0	No	Yes	7	8	2	1
R:R:W102	R:R:Y96	4.82	2	Yes	No	9	6	2	1
L:L:?1	R:R:Y96	16.55	1	Yes	No	0	6	0	1
R:R:A383	R:R:Q97	4.55	0	No	No	6	7	2	1
R:R:Q97	R:R:W387	4.38	0	No	No	7	8	1	2
L:L:?1	R:R:Q97	5.12	1	Yes	No	0	7	0	1
R:R:F112	R:R:W102	4.01	0	Yes	Yes	6	9	1	2
R:R:F112	R:R:I113	3.77	0	Yes	Yes	6	7	1	2
L:L:?1	R:R:F112	6.25	1	Yes	Yes	0	6	0	1
R:R:C120	R:R:D116	3.11	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	10.34	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D116	11.32	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:C120	5.09	1	Yes	No	0	7	0	1
R:R:S199	R:R:Y195	3.82	0	No	Yes	8	8	1	2
L:L:?1	R:R:S199	4.82	1	Yes	No	0	8	0	1
L:L:?1	R:R:A203	3.03	1	Yes	No	0	8	0	1
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F362	R:R:W358	5.01	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	11.79	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	3.62	1	Yes	No	8	7	1	2
L:L:?1	R:R:F361	18.75	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	6.25	1	Yes	Yes	0	7	0	1
R:R:W387	R:R:Y390	7.72	0	No	Yes	8	8	2	1
L:L:?1	R:R:Y390	4.51	1	Yes	Yes	0	8	0	1
R:R:A186	R:R:Y96	2.67	0	No	No	4	6	2	1
R:R:F361	R:R:I385	2.51	1	Yes	No	8	6	1	2
R:R:S199	R:R:Y198	1.27	0	No	No	8	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JT6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	255
Number of Links	268
Number of Hubs	28
Number of Links mediated by Hubs	116
Number of Communities	4
Number of Nodes involved in Communities	21
Number of Links involved in Communities	26

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	47294
Length Of Smallest Path	3
Average Path Length	12.0582
Length of Longest Path	26
Minimum Path Strength	1.41
Average Path Strength	5.86792
Maximum Path Strength	16.075
Minimum Path Correlation	0.7
Average Path Correlation	0.939707
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	59.7798
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.648
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • somatodendritic compartment • dendrite • dendritic tree • periplasmic space
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	EZX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	EZX
Name	1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one
Synonyms
Identifier
Formula	C23 H24 F N3 O
Molecular Weight	377.455
SMILES
PubChem	170838539
Formal Charge	0
Total Atoms	52
Total Chiral Atoms	1
Total Bonds	56
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8JT6_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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