psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F112	3.81	Yes	Yes	1	0	6
2	L:L:?1	R:R:I113	3.35	Yes	No	0	0	7
3	L:L:?1	R:R:D116	30.77	Yes	No	1	0	8
4	L:L:?1	R:R:V117	17.47	Yes	No	0	0	8
5	L:L:?1	R:R:C120	4.96	Yes	No	1	0	7
6	L:L:?1	R:R:T121	4.61	Yes	Yes	1	0	8
7	L:L:?1	R:R:I189	8.93	Yes	No	0	0	6
8	L:L:?1	R:R:S199	4.7	Yes	No	0	0	8
9	L:L:?1	R:R:A203	4.93	Yes	No	1	0	8
10	L:L:?1	R:R:W358	4.45	Yes	Yes	1	0	8
11	L:L:?1	R:R:F361	20.95	Yes	Yes	1	0	8
12	L:L:?1	R:R:F362	10.47	Yes	Yes	1	0	7
13	L:L:?1	R:R:N386	8.59	Yes	No	1	0	7
14	L:L:?1	R:R:Y390	10.08	Yes	Yes	1	0	8
15	R:R:Q36	R:R:Y35	6.76	No	No	0	4	4
16	R:R:Q36	R:R:T39	7.09	No	No	0	4	5
17	R:R:N100	R:R:Q36	3.96	No	No	0	5	4
18	R:R:S40	R:R:V98	6.46	No	No	0	5	6
19	R:R:A94	R:R:L43	4.73	No	No	0	7	7
20	R:R:L43	R:R:W387	14.81	No	Yes	0	7	8
21	R:R:I47	R:R:L90	8.56	No	Yes	0	7	8
22	R:R:A50	R:R:S86	3.42	No	No	0	8	8
23	R:R:V51	R:R:V87	4.81	No	No	3	7	6
24	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
25	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
26	R:R:L83	R:R:N54	4.12	Yes	No	0	8	9
27	R:R:N54	R:R:P397	6.52	No	No	0	9	9
28	R:R:A79	R:R:V57	3.39	No	No	0	9	9
29	R:R:A401	R:R:V57	5.09	No	No	0	8	9
30	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
31	R:R:A60	R:R:F411	5.55	No	No	0	8	8
32	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
33	R:R:I414	R:R:L63	4.28	No	No	0	7	6
34	R:R:E64	R:R:L67	5.3	Yes	Yes	0	7	8
35	R:R:A410	R:R:E64	7.54	No	Yes	0	8	7
36	R:R:E64	R:R:K413	10.8	Yes	No	0	7	6
37	R:R:E64	R:R:I414	4.1	Yes	No	0	7	7
38	R:R:L67	R:R:N72	6.87	Yes	Yes	2	8	9
39	R:R:D406	R:R:L67	4.07	Yes	Yes	2	7	8
40	R:R:F407	R:R:L67	9.74	Yes	Yes	2	8	8
41	R:R:Q68	R:R:Y73	11.27	No	No	0	8	6
42	R:R:N69	R:R:N72	10.9	No	Yes	0	8	9
43	R:R:D133	R:R:V70	4.38	Yes	Yes	4	9	7
44	R:R:R148	R:R:V70	17	No	Yes	4	8	7
45	R:R:P150	R:R:V70	3.53	No	Yes	0	5	7
46	R:R:A153	R:R:V70	5.09	No	Yes	0	7	7
47	R:R:D406	R:R:N72	4.04	Yes	Yes	2	7	9
48	R:R:F407	R:R:N72	7.25	Yes	Yes	2	8	9
49	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
50	R:R:D133	R:R:L74	5.43	Yes	No	0	9	8
51	R:R:L156	R:R:L74	4.15	No	No	0	6	8
52	R:R:I130	R:R:I75	4.42	No	No	1	9	8
53	R:R:I75	R:R:Y400	4.84	No	Yes	1	8	9
54	R:R:H126	R:R:S77	5.58	Yes	No	1	8	9
55	R:R:I157	R:R:S77	9.29	No	No	1	8	9
56	R:R:D82	R:R:L78	6.79	Yes	Yes	1	9	9
57	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
58	R:R:L127	R:R:L78	4.15	Yes	Yes	1	8	9
59	R:R:L78	R:R:N396	9.61	Yes	Yes	1	9	9
60	R:R:L78	R:R:Y400	4.69	Yes	Yes	1	9	9
61	R:R:S122	R:R:T81	7.99	No	No	1	8	9
62	R:R:H126	R:R:T81	10.95	Yes	No	1	8	9
63	R:R:T81	R:R:W161	8.49	No	Yes	1	9	9
64	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
65	R:R:D82	R:R:S393	5.89	Yes	No	0	9	9
66	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
67	R:R:L88	R:R:M84	4.24	No	No	0	6	7
68	R:R:M84	R:R:W161	4.65	No	Yes	0	7	9
69	R:R:C119	R:R:V85	3.42	No	No	0	7	8
70	R:R:C120	R:R:V85	3.42	No	No	0	7	8
71	R:R:S393	R:R:V85	6.46	No	No	0	9	8
72	R:R:F112	R:R:V89	5.24	Yes	No	1	6	8
73	R:R:D116	R:R:V89	7.3	No	No	1	8	8
74	R:R:V89	R:R:Y390	5.05	No	Yes	1	8	8
75	R:R:L90	R:R:W387	3.42	Yes	Yes	1	8	8
76	R:R:L90	R:R:Y390	4.69	Yes	Yes	1	8	8
77	R:R:M92	R:R:W102	3.49	No	Yes	1	6	9
78	R:R:F112	R:R:M92	11.2	Yes	No	1	6	6
79	R:R:A93	R:R:Y390	4	No	Yes	0	7	8
80	R:R:W102	R:R:Y96	8.68	Yes	No	0	9	6
81	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
82	R:R:K101	R:R:L99	4.23	No	Yes	5	5	5
83	R:R:L99	R:R:T103	4.42	Yes	No	5	5	5
84	R:R:K101	R:R:T103	6.01	No	No	5	5	5
85	R:R:D185	R:R:K101	11.06	No	No	0	4	5
86	R:R:L104	R:R:W102	6.83	No	Yes	0	7	9
87	R:R:C109	R:R:W102	6.53	No	Yes	1	9	9
88	R:R:F112	R:R:W102	10.02	Yes	Yes	1	6	9
89	R:R:C187	R:R:W102	10.45	No	Yes	1	9	9
90	R:R:L104	R:R:T108	7.37	No	No	0	7	6
91	R:R:Q106	R:R:R181	3.5	No	No	0	4	4
92	R:R:C109	R:R:C187	7.28	No	No	1	9	9
93	R:R:D110	R:R:R176	10.72	No	No	6	7	6
94	R:R:D110	R:R:R181	13.1	No	No	6	7	4
95	R:R:D116	R:R:Y390	11.49	No	Yes	1	8	8
96	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
97	R:R:F165	R:R:L118	10.96	No	No	0	5	6
98	R:R:L118	R:R:S168	6.01	No	No	0	6	8
99	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
100	R:R:G164	R:R:T121	3.64	No	Yes	0	8	8
101	R:R:I167	R:R:T121	6.08	No	Yes	0	8	8
102	R:R:A203	R:R:T121	5.03	No	Yes	1	8	8
103	R:R:H126	R:R:S122	6.97	Yes	No	1	8	8
104	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
105	R:R:I124	R:R:P207	3.39	No	No	0	8	9
106	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
107	R:R:I124	R:R:W358	14.09	No	Yes	1	8	8
108	R:R:C128	R:R:W125	7.84	No	No	0	7	7
109	R:R:I163	R:R:W125	18.79	No	No	0	5	7
110	R:R:P207	R:R:W125	14.86	No	No	0	9	7
111	R:R:H126	R:R:I157	5.3	Yes	No	1	8	8
112	R:R:H126	R:R:T160	12.32	Yes	No	1	8	8
113	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
114	R:R:F354	R:R:L127	3.65	Yes	Yes	1	9	8
115	R:R:L127	R:R:N396	10.98	Yes	Yes	1	8	9
116	R:R:L127	R:R:Y400	7.03	Yes	Yes	1	8	9
117	R:R:C128	R:R:L210	4.76	No	No	0	7	7
118	R:R:A129	R:R:L156	6.3	No	No	0	8	6
119	R:R:I130	R:R:R134	7.52	No	Yes	1	9	9
120	R:R:I130	R:R:Y400	6.04	No	Yes	1	9	9
121	R:R:A131	R:R:Y215	5.34	No	Yes	0	9	9
122	R:R:L132	R:R:W136	15.94	No	No	0	6	5
123	R:R:L132	R:R:L214	5.54	No	No	0	6	7
124	R:R:D133	R:R:R148	10.72	Yes	No	4	9	8
125	R:R:R134	R:R:Y215	8.23	Yes	Yes	1	9	9
126	R:R:I350	R:R:R134	3.76	Yes	Yes	1	8	9
127	R:R:R134	R:R:Y400	7.2	Yes	Yes	1	9	9
128	R:R:W136	R:R:Y135	3.86	No	Yes	0	5	9
129	R:R:T139	R:R:Y135	12.48	No	Yes	0	8	9
130	R:R:L214	R:R:Y135	7.03	No	Yes	0	7	9
131	R:R:R217	R:R:Y135	12.35	No	Yes	0	7	9
132	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
133	R:R:R152	R:R:W136	5	No	No	0	7	5
134	R:R:I138	R:R:I218	4.42	No	No	0	9	9
135	R:R:D140	R:R:D143	10.65	No	No	0	7	6
136	R:R:D143	R:R:K147	6.91	No	No	0	6	5
137	R:R:R148	R:R:Y144	12.35	No	No	0	8	8
138	R:R:P150	R:R:T149	3.5	No	No	0	5	8
139	R:R:T160	R:R:W161	3.64	No	Yes	1	8	9
140	R:R:F165	R:R:I169	7.54	No	No	0	5	6
141	R:R:I167	R:R:Y198	6.04	No	No	0	8	5
142	R:R:I169	R:R:P170	3.39	No	No	0	6	8
143	R:R:P170	R:R:P171	5.84	No	No	0	8	7
144	R:R:P171	R:R:Y195	15.3	No	Yes	0	7	8
145	R:R:W175	R:R:Y195	9.65	No	Yes	0	6	8
146	R:R:W175	R:R:Y198	5.79	No	No	0	6	5
147	R:R:D180	R:R:R176	15.48	No	No	0	4	6
148	R:R:R176	R:R:R181	9.6	No	No	6	6	4
149	R:R:P178	R:R:T177	3.5	No	No	0	5	5
150	R:R:D183	R:R:P184	4.83	No	No	0	1	1
151	R:R:A186	R:R:D183	4.63	No	No	0	4	1
152	R:R:S190	R:R:Y195	6.36	No	Yes	0	6	8
153	R:R:F370	R:R:H193	18.1	No	No	0	5	4
154	R:R:E372	R:R:H193	6.15	No	No	0	3	4
155	R:R:S199	R:R:Y195	12.72	No	Yes	0	8	8
156	R:R:P369	R:R:T196	12.24	No	No	0	7	7
157	R:R:F201	R:R:I197	3.77	No	No	0	5	7
158	R:R:F370	R:R:I197	5.02	No	No	0	5	7
159	R:R:F362	R:R:T200	5.19	Yes	No	0	7	7
160	R:R:L366	R:R:T200	7.37	No	No	0	7	7
161	R:R:F201	R:R:Y205	9.28	No	No	1	5	7
162	R:R:F201	R:R:L366	4.87	No	No	1	5	7
163	R:R:F204	R:R:Y205	9.28	Yes	No	1	8	7
164	R:R:F204	R:R:L208	9.74	Yes	Yes	1	8	7
165	R:R:F204	R:R:F354	8.57	Yes	Yes	1	8	9
166	R:R:F204	R:R:L359	6.09	Yes	No	0	8	7
167	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
168	R:R:L366	R:R:Y205	5.86	No	No	1	7	7
169	R:R:I206	R:R:P207	3.39	No	No	0	6	9
170	R:R:L208	R:R:L212	4.15	Yes	No	0	7	6
171	R:R:F354	R:R:L208	4.87	Yes	Yes	1	9	7
172	R:R:I355	R:R:L208	5.71	Yes	Yes	0	7	7
173	R:R:M211	R:R:M351	4.33	No	No	0	9	8
174	R:R:F354	R:R:M211	4.98	Yes	No	0	9	9
175	R:R:R217	R:R:V213	5.23	No	No	0	7	5
176	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
177	R:R:L347	R:R:Y215	3.52	No	Yes	0	8	9
178	R:R:I350	R:R:Y215	8.46	Yes	Yes	1	8	9
179	R:R:F219	R:R:R223	11.76	Yes	No	0	6	7
180	R:R:F219	R:R:T343	5.19	Yes	No	0	6	8
181	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
182	R:R:E340	R:R:R223	17.45	No	No	0	8	7
183	R:R:F224	R:R:R225	4.28	No	No	7	6	7
184	R:R:F224	R:R:K228	8.69	No	No	7	6	5
185	R:R:K228	R:R:R225	8.66	No	No	7	5	7
186	R:R:I226	R:R:R339	3.76	No	No	0	6	7
187	R:R:E340	R:R:I226	5.47	No	No	0	8	6
188	R:R:E340	R:R:R227	6.98	No	No	0	8	6
189	R:R:E326	R:R:K324	14.85	No	No	0	3	1
190	R:R:K324	R:R:R327	3.71	No	No	0	1	3
191	R:R:E330	R:R:R333	11.63	No	No	0	4	4
192	R:R:K334	R:R:R333	8.66	No	No	0	5	4
193	R:R:L337	R:R:R333	3.64	No	No	0	5	4
194	R:R:M335	R:R:R339	11.17	No	No	0	4	7
195	R:R:I349	R:R:K345	4.36	No	No	0	7	7
196	R:R:I350	R:R:Y400	3.63	Yes	Yes	1	8	9
197	R:R:I399	R:R:T353	9.12	No	No	0	8	7
198	R:R:F354	R:R:W358	4.01	Yes	Yes	1	9	8
199	R:R:I355	R:R:L359	7.14	Yes	No	0	7	7
200	R:R:C357	R:R:N392	9.45	No	No	0	8	9
201	R:R:F362	R:R:W358	8.02	Yes	Yes	1	7	8
202	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
203	R:R:N392	R:R:W358	12.43	No	Yes	0	9	8
204	R:R:I363	R:R:L359	7.14	No	No	0	7	7
205	R:R:I385	R:R:P360	3.39	Yes	No	0	6	9
206	R:R:F361	R:R:F362	12.86	Yes	Yes	1	8	7
207	R:R:F361	R:R:I385	3.77	Yes	Yes	0	8	6
208	R:R:F361	R:R:N386	7.25	Yes	No	1	8	7
209	R:R:I385	R:R:V364	4.61	Yes	No	0	6	6
210	R:R:L368	R:R:M377	5.65	No	No	0	4	4
211	R:R:C371	R:R:C375	7.28	No	No	0	5	4
212	R:R:M377	R:R:P378	6.71	No	No	0	4	7
213	R:R:L381	R:R:M377	4.24	No	No	0	6	4
214	R:R:I384	R:R:L380	4.28	No	No	0	4	3
215	R:R:G382	R:R:I385	3.53	No	Yes	0	4	6
216	R:R:W387	R:R:Y390	19.29	Yes	Yes	1	8	8
217	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
218	R:R:V398	R:R:Y402	3.79	No	Yes	0	6	6
219	R:R:F403	R:R:V398	3.93	No	No	0	8	6
220	R:R:I399	R:R:Y400	6.04	No	Yes	0	8	9
221	R:R:A401	R:R:F407	6.93	No	Yes	0	8	8
222	R:R:F411	R:R:Y402	8.25	No	Yes	0	8	6
223	R:R:D406	R:R:N404	12.12	Yes	No	2	7	9
224	R:R:F407	R:R:N404	13.29	Yes	No	2	8	9
225	R:R:K405	R:R:Q408	5.42	No	No	0	6	9
226	R:R:D406	R:R:F407	4.78	Yes	Yes	2	7	8
227	R:R:Q97	R:R:W387	3.29	No	Yes	0	7	8
228	R:R:A114	R:R:M172	3.22	No	No	0	7	6
229	R:R:D140	R:R:P141	3.22	No	No	0	7	8
230	R:R:V58	R:R:V80	3.21	No	No	0	7	7
231	R:R:C56	R:R:L52	3.17	No	No	0	8	4
232	R:R:A50	R:R:L394	3.15	No	No	0	8	7
233	R:R:L74	R:R:S77	3	No	No	0	8	9
234	R:R:L90	R:R:S86	3	Yes	No	0	8	8
235	R:R:L159	R:R:S158	3	No	No	0	3	5
236	R:R:L83	R:R:V51	2.98	Yes	No	3	8	7
237	R:R:L83	R:R:V87	2.98	Yes	No	3	8	6
238	R:R:L88	R:R:V87	2.98	No	No	0	6	6
239	R:R:L99	R:R:V98	2.98	Yes	No	0	5	6
240	R:R:L368	R:R:V364	2.98	No	No	0	4	6
241	R:R:N146	R:R:V145	2.96	No	No	0	5	6
242	R:R:L395	R:R:T353	2.95	No	No	0	6	7
243	R:R:D180	R:R:S190	2.94	No	No	0	4	6
244	R:R:I349	R:R:I399	2.94	No	No	0	7	8
245	R:R:E179	R:R:S182	2.87	No	No	0	3	3
246	R:R:I169	R:R:L173	2.85	No	No	0	6	6
247	R:R:I355	R:R:L356	2.85	Yes	No	0	7	5
248	R:R:G105	R:R:W102	2.81	No	Yes	0	7	9
249	R:R:K412	R:R:N409	2.8	No	No	0	6	6
250	R:R:C56	R:R:F411	2.79	No	No	0	8	8
251	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
252	R:R:L115	R:R:L88	2.77	No	No	0	5	6
253	R:R:L95	R:R:L99	2.77	No	Yes	0	6	5
254	R:R:L162	R:R:L166	2.77	No	No	0	5	5
255	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
256	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
257	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
258	R:R:R151	R:R:T149	2.59	No	No	0	6	8
259	R:R:F370	R:R:T196	2.59	No	No	0	5	7
260	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
261	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
262	R:R:R217	R:R:R220	2.13	No	No	0	7	5
263	R:R:A79	R:R:G76	1.95	No	No	0	9	6
264	R:R:G202	R:R:I167	1.76	No	No	0	5	8
265	R:R:G202	R:R:I206	1.76	No	No	0	5	6
266	R:R:G352	R:R:I355	1.76	No	Yes	0	6	7
267	R:R:C375	R:R:S374	1.72	No	No	0	4	5
268	R:R:C371	R:R:V367	1.71	No	No	0	5	6
269	R:R:G389	R:R:L388	1.71	No	No	0	8	8
270	R:R:A79	R:R:V58	1.7	No	No	0	9	7
271	R:R:C49	R:R:T45	1.69	No	No	0	5	4
272	R:R:A186	R:R:T188	1.68	No	No	0	4	5
273	R:R:D192	R:R:G194	1.68	No	No	0	6	5
274	R:R:A222	R:R:T343	1.68	No	No	0	8	8
275	R:R:K191	R:R:P369	1.67	No	No	0	5	7
276	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
277	R:R:S373	R:R:S374	1.63	No	No	0	3	5
278	R:R:A221	R:R:I138	1.62	No	No	0	6	9
279	R:R:A336	R:R:I226	1.62	No	No	0	5	6
280	R:R:S40	R:R:T39	1.6	No	No	0	5	5
281	R:R:C49	R:R:L394	1.59	No	No	0	5	7
282	R:R:C375	R:R:L368	1.59	No	No	0	4	4
283	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
284	R:R:A59	R:R:L63	1.58	No	No	0	5	6
285	R:R:P184	R:R:Q106	1.58	No	No	0	1	4
286	R:R:A71	R:R:D133	1.54	No	Yes	0	8	9
287	R:R:I350	R:R:T346	1.52	Yes	No	0	8	8
288	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
289	R:R:L46	R:R:S391	1.5	No	No	0	7	5
290	R:R:L388	R:R:S391	1.5	No	No	0	8	5
291	R:R:L41	R:R:V37	1.49	No	No	0	4	5
292	R:R:L43	R:R:V98	1.49	No	No	0	7	6
293	R:R:L111	R:R:V107	1.49	No	No	0	5	4
294	R:R:L209	R:R:V213	1.49	No	No	0	5	5
295	R:R:I38	R:R:L42	1.43	No	No	0	3	5
296	R:R:I142	R:R:N146	1.42	No	No	0	6	5
297	R:R:L111	R:R:M172	1.41	No	No	0	5	6
298	R:R:G174	R:R:W175	1.41	No	No	0	5	6
299	R:R:E179	R:R:T177	1.41	No	No	0	3	5
300	R:R:D140	R:R:I142	1.4	No	No	0	7	6
301	R:R:K147	R:R:N146	1.4	No	No	0	5	5
302	R:R:K405	R:R:N409	1.4	No	No	0	6	6
303	R:R:V145	R:R:Y144	1.26	No	No	0	6	8
304	R:R:F48	R:R:L52	1.22	No	No	0	4	4
305	R:R:L166	R:R:Y198	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.86214	14	1	0
2	R:R:E64	6.935	4	0	7
3	R:R:L67	6.495	4	2	8
4	R:R:V70	7.5	4	4	7
5	R:R:N72	7.265	4	2	9
6	R:R:L78	6.59	5	1	9
7	R:R:D82	6.676	5	1	9
8	R:R:L83	2.915	4	3	8
9	R:R:L90	4.262	5	1	8
10	R:R:L99	3.6	4	5	5
11	R:R:W102	6.97286	7	1	9
12	R:R:F112	7.5675	4	1	6
13	R:R:T121	4.84	4	1	8
14	R:R:H126	7.73143	7	1	8
15	R:R:L127	6.4525	4	1	8
16	R:R:D133	5.5175	4	4	9
17	R:R:R134	6.6775	4	1	9
18	R:R:Y135	7.87	5	0	9
19	R:R:W161	7.715	6	1	9
20	R:R:Y195	9.266	5	0	8
21	R:R:F204	10.808	5	1	8
22	R:R:L208	6.1175	4	1	7
23	R:R:Y215	5.836	5	1	9
24	R:R:F219	4.946	5	0	6
25	R:R:I350	4.3425	4	1	8
26	R:R:F354	5.18333	6	1	9
27	R:R:I355	4.365	4	0	7
28	R:R:W358	8.09429	7	1	8
29	R:R:F361	9.52	5	1	8
30	R:R:F362	11.38	5	1	7
31	R:R:I385	3.825	4	0	6
32	R:R:W387	8.618	5	1	8
33	R:R:Y390	9.1	6	1	8
34	R:R:N396	10.2325	4	1	9
35	R:R:Y400	5.63857	7	1	9
36	R:R:Y402	4.844	5	0	6
37	R:R:D406	6.2525	4	2	7
38	R:R:F407	7.835	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	51.494	10.08	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	32.7568	19.29	Yes	Yes	1	8	8
3	R:R:L43	R:R:W387	25.8495	14.81	No	Yes	0	7	8
4	R:R:L43	R:R:V98	22.0689	1.49	No	No	0	7	6
5	R:R:S40	R:R:V98	10.1946	6.46	No	No	0	5	6
6	R:R:L90	R:R:Y390	15.2226	4.69	Yes	Yes	1	8	8
7	R:R:L90	R:R:S86	10.1669	3	Yes	No	0	8	8
8	L:L:?1	R:R:C120	20.0787	4.96	Yes	No	1	0	7
9	R:R:C120	R:R:V85	20.8437	3.42	No	No	0	7	8
10	R:R:S393	R:R:V85	20.5776	6.46	No	No	0	9	8
11	R:R:D82	R:R:S393	20.6996	5.89	Yes	No	0	9	9
12	R:R:D82	R:R:N54	72.1104	6.73	Yes	No	0	9	9
13	R:R:L83	R:R:N54	10.9097	4.12	Yes	No	0	8	9
14	L:L:?1	R:R:W358	90.0992	4.45	Yes	Yes	1	0	8
15	R:R:N392	R:R:W358	46.2609	12.43	No	Yes	0	9	8
16	R:R:N392	R:R:N396	46.8707	12.26	No	Yes	0	9	9
17	R:R:D82	R:R:N396	30.872	8.08	Yes	Yes	1	9	9
18	R:R:N54	R:R:P397	61.5666	6.52	No	No	0	9	9
19	R:R:P397	R:R:Y402	59.5986	2.78	No	Yes	0	9	6
20	R:R:V57	R:R:Y402	41.3881	5.05	No	Yes	0	9	6
21	R:R:A401	R:R:V57	30.8831	5.09	No	No	0	8	9
22	R:R:F411	R:R:Y402	11.2756	8.25	No	Yes	0	8	6
23	R:R:A401	R:R:F407	28.7488	6.93	No	Yes	0	8	8
24	R:R:F407	R:R:L67	15.594	9.74	Yes	Yes	2	8	8
25	R:R:E64	R:R:L67	13.5318	5.3	Yes	Yes	0	7	8
26	R:R:F354	R:R:W358	65.9017	4.01	Yes	Yes	1	9	8
27	R:R:F354	R:R:L127	100	3.65	Yes	Yes	1	9	8
28	R:R:L127	R:R:L78	35.2071	4.15	Yes	Yes	1	8	9
29	R:R:H126	R:R:L78	70.1369	7.71	Yes	Yes	1	8	9
30	R:R:H126	R:R:S77	51.3776	5.58	Yes	No	1	8	9
31	R:R:L74	R:R:S77	49.3874	3	No	No	0	8	9
32	R:R:D133	R:R:L74	42.968	5.43	Yes	No	0	9	8
33	R:R:D133	R:R:V70	15.9044	4.38	Yes	Yes	4	9	7
34	R:R:P150	R:R:V70	11.6913	3.53	No	Yes	0	5	7
35	R:R:L78	R:R:N396	21.4923	9.61	Yes	Yes	1	9	9
36	R:R:D133	R:R:R148	22.723	10.72	Yes	No	4	9	8
37	R:R:L127	R:R:Y400	59.8259	7.03	Yes	Yes	1	8	9
38	R:R:H126	R:R:W161	16.9466	5.29	Yes	Yes	1	8	9
39	L:L:?1	R:R:F112	19.2971	3.81	Yes	Yes	1	0	6
40	R:R:F112	R:R:W102	14.9343	10.02	Yes	Yes	1	6	9
41	R:R:L99	R:R:V98	10.1946	2.98	Yes	No	0	5	6
42	L:L:?1	R:R:S199	32.4076	4.7	Yes	No	0	0	8
43	R:R:S199	R:R:Y195	30.7057	12.72	No	Yes	0	8	8
44	R:R:S190	R:R:Y195	20.2838	6.36	No	Yes	0	6	8
45	R:R:D180	R:R:S190	18.3048	2.94	No	No	0	4	6
46	R:R:D180	R:R:R176	16.3147	15.48	No	No	0	4	6
47	R:R:R176	R:R:R181	12.2679	9.6	No	No	6	6	4
48	R:R:Q106	R:R:R181	10.2777	3.5	No	No	0	4	4
49	R:R:L118	R:R:W161	10.5715	5.69	No	Yes	0	6	9
50	L:L:?1	R:R:T121	12.0073	4.61	Yes	Yes	1	0	8
51	R:R:I124	R:R:P207	12.8222	3.39	No	No	0	8	9
52	R:R:R134	R:R:Y400	40.6231	7.2	Yes	Yes	1	9	9
53	R:R:R134	R:R:Y215	39.7472	8.23	Yes	Yes	1	9	9
54	R:R:I350	R:R:Y400	41.9979	3.63	Yes	Yes	1	8	9
55	R:R:I350	R:R:Y215	39.592	8.46	Yes	Yes	1	8	9
56	R:R:I218	R:R:Y215	39.4534	3.63	No	Yes	0	9	9
57	R:R:I218	R:R:Y135	31.1547	3.63	No	Yes	0	9	9
58	R:R:R217	R:R:Y135	11.525	12.35	No	Yes	0	7	9
59	R:R:R148	R:R:Y144	20.8493	12.35	No	No	0	8	8
60	R:R:V145	R:R:Y144	16.2925	1.26	No	No	0	6	8
61	R:R:N146	R:R:V145	13.9975	2.96	No	No	0	5	6
62	L:L:?1	R:R:F362	13.0218	10.47	Yes	Yes	1	0	7
63	R:R:F201	R:R:I197	16.4865	3.77	No	No	0	5	7
64	R:R:F370	R:R:I197	14.1638	5.02	No	No	0	5	7
65	R:R:F204	R:R:F362	21.0987	20.36	Yes	Yes	1	8	7
66	R:R:F204	R:R:Y205	16.9189	9.28	Yes	No	1	8	7
67	R:R:F201	R:R:Y205	14.0972	9.28	No	No	1	5	7
68	R:R:L347	R:R:Y215	36.7038	3.52	No	Yes	0	8	9
69	R:R:F219	R:R:L347	33.9376	3.65	Yes	No	0	6	8
70	R:R:F219	R:R:R223	19.9401	11.76	Yes	No	0	6	7
71	R:R:E340	R:R:R223	17.0963	17.45	No	No	0	8	7
72	R:R:E340	R:R:I226	11.5029	5.47	No	No	0	8	6
73	L:L:?1	R:R:F361	26.1046	20.95	Yes	Yes	1	0	8
74	R:R:F361	R:R:I385	46.9095	3.77	Yes	Yes	0	8	6
75	R:R:I385	R:R:V364	36.2492	4.61	Yes	No	0	6	6
76	R:R:L368	R:R:V364	32.6737	2.98	No	No	0	4	6
77	R:R:L368	R:R:M377	10.9873	5.65	No	No	0	4	4
78	R:R:C375	R:R:L368	18.2604	1.59	No	No	0	4	4
79	R:R:F362	R:R:W358	19.8237	8.02	Yes	Yes	1	7	8
80	R:R:D82	R:R:L78	28.6546	6.79	Yes	Yes	1	9	9
81	R:R:F204	R:R:F354	24.6577	8.57	Yes	Yes	1	8	9
82	R:R:F361	R:R:F362	27.9395	12.86	Yes	Yes	1	8	7
83	R:R:L78	R:R:Y400	30.9773	4.69	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F112	3.81	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I113	3.35	1	Yes	No	0	7	0	1
L:L:?1	R:R:D116	30.77	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	17.47	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	4.96	1	Yes	No	0	7	0	1
L:L:?1	R:R:T121	4.61	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I189	8.93	1	Yes	No	0	6	0	1
L:L:?1	R:R:S199	4.7	1	Yes	No	0	8	0	1
L:L:?1	R:R:A203	4.93	1	Yes	No	0	8	0	1
L:L:?1	R:R:W358	4.45	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	20.95	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	10.47	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.59	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	10.08	1	Yes	Yes	0	8	0	1
R:R:C120	R:R:V85	3.42	1	No	No	7	8	1	2
R:R:F112	R:R:V89	5.24	1	Yes	No	6	8	1	2
R:R:D116	R:R:V89	7.3	1	No	No	8	8	1	2
R:R:V89	R:R:Y390	5.05	1	No	Yes	8	8	2	1
R:R:L90	R:R:W387	3.42	1	Yes	Yes	8	8	2	2
R:R:L90	R:R:Y390	4.69	1	Yes	Yes	8	8	2	1
R:R:M92	R:R:W102	3.49	1	No	Yes	6	9	2	2
R:R:F112	R:R:M92	11.2	1	Yes	No	6	6	1	2
R:R:A93	R:R:Y390	4	0	No	Yes	7	8	2	1
R:R:F112	R:R:W102	10.02	1	Yes	Yes	6	9	1	2
R:R:D116	R:R:Y390	11.49	1	No	Yes	8	8	1	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	1
R:R:G164	R:R:T121	3.64	0	No	Yes	8	8	2	1
R:R:I167	R:R:T121	6.08	0	No	Yes	8	8	2	1
R:R:A203	R:R:T121	5.03	1	No	Yes	8	8	1	1
R:R:F354	R:R:I124	5.02	1	Yes	No	9	8	2	2
R:R:I124	R:R:W358	14.09	1	No	Yes	8	8	2	1
R:R:S199	R:R:Y195	12.72	0	No	Yes	8	8	1	2
R:R:F362	R:R:T200	5.19	1	Yes	No	7	7	1	2
R:R:F204	R:R:F354	8.57	1	Yes	Yes	8	9	2	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F354	R:R:W358	4.01	1	Yes	Yes	9	8	2	1
R:R:F362	R:R:W358	8.02	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	8.44	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	12.43	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	12.86	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:I385	3.77	1	Yes	Yes	8	6	1	2
R:R:F361	R:R:N386	7.25	1	Yes	No	8	7	1	1
R:R:W387	R:R:Y390	19.29	1	Yes	Yes	8	8	2	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FYT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	269
Number of Links	305
Number of Hubs	38
Number of Links mediated by Hubs	152
Number of Communities	7
Number of Nodes involved in Communities	62
Number of Links involved in Communities	91

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	50525
Length Of Smallest Path	3
Average Path Length	11.9385
Length of Longest Path	27
Minimum Path Strength	1.41
Average Path Strength	6.6009
Maximum Path Strength	25.86
Minimum Path Correlation	0.7
Average Path Correlation	0.936966
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	62.7275
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.8875
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • serotonin binding • amine binding • heterocyclic compound binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • ammonium ion metabolic process • serotonin metabolic process • indole-containing compound metabolic process • primary amino compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • periplasmic space • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • response to hormone • response to endogenous stimulus • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7LD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7LD
Name	Lysergic acid diethylamide
Synonyms	N,N-diethyllysergamide
Identifier
Formula	C20 H25 N3 O
Molecular Weight	323.432
SMILES
PubChem	5761
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8FYT_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	t7m	Gi1/β1/γ1	2.9	2024-05-29	To be published
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	t7m		2.9	2024-05-29	To be published
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	t7m	Gi1/β1/γ1	2.4	2024-05-29	To be published
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	t7m		2.4	2024-05-29	To be published
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	10.1038/s41586-024-07403-2
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	To be published
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	To be published
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	10.1038/s41586-023-06804-z
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	10.1038/s41586-021-03376-8
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	10.1038/s41586-021-03376-8

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