psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D116	13.85	Yes	No	1	0	8
2	L:L:?1	R:R:V117	11.94	Yes	No	0	0	8
3	L:L:?1	R:R:C120	4.63	Yes	No	1	0	7
4	L:L:?1	R:R:T121	5.37	Yes	Yes	1	0	8
5	L:L:?1	R:R:I189	10.4	Yes	No	0	0	6
6	L:L:?1	R:R:S199	8.75	Yes	No	0	0	8
7	L:L:?1	R:R:A203	3.45	Yes	No	1	0	8
8	L:L:?1	R:R:W358	4.15	Yes	Yes	1	0	8
9	L:L:?1	R:R:F361	16.87	Yes	Yes	1	0	8
10	L:L:?1	R:R:F362	11.54	Yes	Yes	1	0	7
11	L:L:?1	R:R:Y390	11.96	Yes	Yes	1	0	8
12	R:R:Q36	R:R:Y35	12.4	No	No	0	4	4
13	R:R:T39	R:R:V98	3.17	No	No	0	5	6
14	R:R:S40	R:R:V98	3.23	No	No	0	5	6
15	R:R:A94	R:R:L43	4.73	No	No	0	7	7
16	R:R:L43	R:R:W387	17.08	No	Yes	0	7	8
17	R:R:G44	R:R:I47	5.29	No	No	0	4	7
18	R:R:L46	R:R:S391	4.5	No	No	0	7	5
19	R:R:A50	R:R:S86	3.42	No	No	0	8	8
20	R:R:A50	R:R:L394	3.15	No	No	0	8	7
21	R:R:V51	R:R:V87	3.21	No	No	0	7	6
22	R:R:C56	R:R:L52	3.17	No	No	0	8	4
23	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
24	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
25	R:R:L83	R:R:N54	4.12	No	No	0	8	9
26	R:R:N54	R:R:P397	6.52	No	No	0	9	9
27	R:R:A79	R:R:V57	3.39	No	No	0	9	9
28	R:R:A401	R:R:V57	5.09	No	No	0	8	9
29	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
30	R:R:V58	R:R:V80	4.81	No	No	0	7	7
31	R:R:A60	R:R:F411	5.55	No	No	0	8	8
32	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
33	R:R:E64	R:R:L63	3.98	Yes	No	0	7	6
34	R:R:I414	R:R:L63	7.14	No	No	0	7	6
35	R:R:E64	R:R:L67	5.3	Yes	Yes	2	7	8
36	R:R:A410	R:R:E64	6.03	No	Yes	2	8	7
37	R:R:E64	R:R:K413	9.45	Yes	No	0	7	6
38	R:R:L67	R:R:N72	8.24	Yes	Yes	2	8	9
39	R:R:D406	R:R:L67	4.07	Yes	Yes	2	7	8
40	R:R:F407	R:R:L67	8.53	Yes	Yes	2	8	8
41	R:R:A410	R:R:L67	3.15	No	Yes	2	8	8
42	R:R:Q68	R:R:Y73	11.27	No	No	0	8	6
43	R:R:N69	R:R:N72	9.54	No	Yes	0	8	9
44	R:R:R148	R:R:V70	14.38	No	No	0	8	7
45	R:R:P150	R:R:V70	3.53	No	No	0	5	7
46	R:R:D406	R:R:N72	5.39	Yes	Yes	2	7	9
47	R:R:F407	R:R:N72	9.67	Yes	Yes	2	8	9
48	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
49	R:R:D133	R:R:L74	5.43	No	No	0	9	8
50	R:R:L156	R:R:L74	4.15	No	No	0	6	8
51	R:R:H126	R:R:S77	5.58	Yes	No	1	8	9
52	R:R:I157	R:R:S77	12.39	No	No	1	8	9
53	R:R:D82	R:R:L78	8.14	Yes	Yes	1	9	9
54	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
55	R:R:L127	R:R:L78	4.15	Yes	Yes	1	8	9
56	R:R:I130	R:R:L78	4.28	No	Yes	1	9	9
57	R:R:L78	R:R:N396	9.61	Yes	Yes	1	9	9
58	R:R:L78	R:R:Y400	3.52	Yes	Yes	1	9	9
59	R:R:S122	R:R:T81	6.4	Yes	No	1	8	9
60	R:R:H126	R:R:T81	8.21	Yes	No	1	8	9
61	R:R:T81	R:R:W161	8.49	No	Yes	1	9	9
62	R:R:D82	R:R:S123	5.89	Yes	No	0	9	9
63	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
64	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
65	R:R:L88	R:R:M84	5.65	No	No	0	6	7
66	R:R:C119	R:R:M84	3.24	No	No	0	7	7
67	R:R:M84	R:R:W161	4.65	No	Yes	0	7	9
68	R:R:C119	R:R:V85	3.42	No	No	0	7	8
69	R:R:C120	R:R:V85	3.42	No	No	0	7	8
70	R:R:S393	R:R:V85	4.85	No	No	0	9	8
71	R:R:L90	R:R:S86	4.5	Yes	No	0	8	8
72	R:R:D116	R:R:V89	4.38	No	Yes	1	8	8
73	R:R:C119	R:R:V89	3.42	No	Yes	0	7	8
74	R:R:V89	R:R:Y390	3.79	Yes	Yes	1	8	8
75	R:R:L90	R:R:W387	4.56	Yes	Yes	1	8	8
76	R:R:L90	R:R:Y390	5.86	Yes	Yes	1	8	8
77	R:R:F112	R:R:M92	9.95	No	No	0	6	6
78	R:R:A93	R:R:Y390	4	No	Yes	0	7	8
79	R:R:L95	R:R:L99	5.54	No	No	0	6	5
80	R:R:L104	R:R:L95	4.15	No	No	0	7	6
81	R:R:W102	R:R:Y96	6.75	Yes	No	3	9	6
82	R:R:C187	R:R:Y96	5.38	Yes	No	3	9	6
83	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
84	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
85	R:R:L99	R:R:T103	4.42	No	No	0	5	5
86	R:R:K101	R:R:T103	4.5	No	No	0	5	5
87	R:R:D185	R:R:K101	9.68	No	No	0	4	5
88	R:R:L104	R:R:W102	21.64	No	Yes	0	7	9
89	R:R:C109	R:R:W102	7.84	No	Yes	3	9	9
90	R:R:F112	R:R:W102	5.01	No	Yes	0	6	9
91	R:R:C187	R:R:W102	7.84	Yes	Yes	3	9	9
92	R:R:L104	R:R:T108	7.37	No	No	0	7	6
93	R:R:C109	R:R:I113	3.27	No	No	3	9	7
94	R:R:C109	R:R:C187	7.28	No	Yes	3	9	9
95	R:R:D110	R:R:M172	8.32	No	No	0	7	6
96	R:R:D110	R:R:R176	3.57	No	Yes	0	7	6
97	R:R:C187	R:R:I113	3.27	Yes	No	3	9	7
98	R:R:A114	R:R:M172	3.22	No	No	0	7	6
99	R:R:D116	R:R:Y390	8.05	No	Yes	1	8	8
100	R:R:I167	R:R:V117	3.07	Yes	No	0	8	8
101	R:R:S168	R:R:V117	4.85	No	No	0	8	8
102	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
103	R:R:F165	R:R:L118	10.96	No	No	0	5	6
104	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
105	R:R:G164	R:R:T121	3.64	No	Yes	0	8	8
106	R:R:I167	R:R:T121	4.56	Yes	Yes	0	8	8
107	R:R:A203	R:R:T121	5.03	No	Yes	1	8	8
108	R:R:H126	R:R:S122	4.18	Yes	Yes	1	8	8
109	R:R:S122	R:R:T160	3.2	Yes	No	1	8	8
110	R:R:S122	R:R:W161	18.53	Yes	Yes	1	8	9
111	R:R:I124	R:R:P207	3.39	No	No	0	8	9
112	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
113	R:R:I124	R:R:W358	15.27	No	Yes	1	8	8
114	R:R:C128	R:R:W125	3.92	No	No	0	7	7
115	R:R:I163	R:R:W125	15.27	No	No	0	5	7
116	R:R:P207	R:R:W125	16.21	No	No	0	9	7
117	R:R:H126	R:R:I157	6.63	Yes	No	1	8	8
118	R:R:H126	R:R:T160	13.69	Yes	No	1	8	8
119	R:R:H126	R:R:W161	4.23	Yes	Yes	1	8	9
120	R:R:F354	R:R:L127	3.65	Yes	Yes	1	9	8
121	R:R:L127	R:R:N396	10.98	Yes	Yes	1	8	9
122	R:R:L127	R:R:Y400	5.86	Yes	Yes	1	8	9
123	R:R:C128	R:R:L210	4.76	No	No	0	7	7
124	R:R:A129	R:R:L156	3.15	No	No	0	8	6
125	R:R:I130	R:R:R134	5.01	No	No	1	9	9
126	R:R:I130	R:R:Y400	6.04	No	Yes	1	9	9
127	R:R:A131	R:R:Y215	5.34	No	Yes	0	9	9
128	R:R:L132	R:R:W136	14.81	No	No	0	6	5
129	R:R:L132	R:R:L214	5.54	No	No	0	6	7
130	R:R:D133	R:R:R148	11.91	No	No	0	9	8
131	R:R:R134	R:R:Y215	7.2	No	Yes	0	9	9
132	R:R:R134	R:R:Y400	7.2	No	Yes	1	9	9
133	R:R:W136	R:R:Y135	3.86	No	Yes	0	5	9
134	R:R:T139	R:R:Y135	12.48	No	Yes	0	8	9
135	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
136	R:R:R217	R:R:Y135	11.32	No	Yes	0	7	9
137	R:R:I218	R:R:Y135	4.84	No	Yes	0	9	9
138	R:R:R152	R:R:W136	7	No	No	0	7	5
139	R:R:I138	R:R:T139	3.04	No	No	0	9	8
140	R:R:D140	R:R:P141	3.22	No	No	0	7	8
141	R:R:D140	R:R:D143	6.65	No	No	0	7	6
142	R:R:D143	R:R:K147	4.15	No	No	0	6	5
143	R:R:D143	R:R:R152	10.72	No	No	0	6	7
144	R:R:R148	R:R:Y144	11.32	No	No	0	8	8
145	R:R:P150	R:R:T149	3.5	No	No	0	5	8
146	R:R:L162	R:R:L166	4.15	No	No	0	5	5
147	R:R:I167	R:R:Y198	6.04	Yes	No	0	8	5
148	R:R:I169	R:R:P170	3.39	No	No	0	6	8
149	R:R:P170	R:R:P171	5.84	No	No	0	8	7
150	R:R:P170	R:R:Y198	5.56	No	No	0	8	5
151	R:R:P171	R:R:Y195	16.69	No	Yes	0	7	8
152	R:R:W175	R:R:Y195	6.75	No	Yes	0	6	8
153	R:R:W175	R:R:Y198	5.79	No	No	0	6	5
154	R:R:D180	R:R:R176	19.06	No	Yes	0	4	6
155	R:R:R176	R:R:R181	5.33	Yes	No	0	6	4
156	R:R:R176	R:R:S190	5.27	Yes	No	0	6	6
157	R:R:P178	R:R:T177	3.5	No	No	0	5	5
158	R:R:E179	R:R:T177	4.23	No	No	0	3	5
159	R:R:D180	R:R:T188	4.34	No	No	0	4	5
160	R:R:D183	R:R:P184	3.22	No	No	0	1	1
161	R:R:A186	R:R:D183	4.63	No	No	0	4	1
162	R:R:S190	R:R:Y195	3.82	No	Yes	0	6	8
163	R:R:K191	R:R:P369	3.35	No	No	0	5	7
164	R:R:F370	R:R:H193	21.5	No	No	0	5	4
165	R:R:S199	R:R:Y195	13.99	No	Yes	0	8	8
166	R:R:P369	R:R:T196	10.49	No	No	0	7	7
167	R:R:F201	R:R:I197	5.02	No	No	0	5	7
168	R:R:F370	R:R:I197	5.02	No	No	0	5	7
169	R:R:T200	R:R:Y205	3.75	No	Yes	1	7	7
170	R:R:F362	R:R:T200	5.19	Yes	No	1	7	7
171	R:R:L366	R:R:T200	8.84	No	No	0	7	7
172	R:R:F201	R:R:Y205	7.22	No	Yes	0	5	7
173	R:R:F204	R:R:Y205	8.25	Yes	Yes	1	8	7
174	R:R:F204	R:R:L208	9.74	Yes	No	1	8	7
175	R:R:F204	R:R:F354	6.43	Yes	Yes	1	8	9
176	R:R:F204	R:R:L359	6.09	Yes	Yes	0	8	7
177	R:R:F204	R:R:F362	19.29	Yes	Yes	1	8	7
178	R:R:F362	R:R:Y205	3.09	Yes	Yes	1	7	7
179	R:R:I206	R:R:P207	3.39	No	No	0	6	9
180	R:R:L208	R:R:L212	4.15	No	No	0	7	6
181	R:R:F354	R:R:L208	3.65	Yes	No	1	9	7
182	R:R:L210	R:R:L214	4.15	No	No	0	7	7
183	R:R:M211	R:R:Y215	5.99	No	Yes	0	9	9
184	R:R:M211	R:R:M351	4.33	No	No	0	9	8
185	R:R:F354	R:R:M211	7.46	Yes	No	0	9	9
186	R:R:L212	R:R:M351	4.24	No	No	0	6	8
187	R:R:R217	R:R:V213	3.92	No	No	0	7	5
188	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
189	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
190	R:R:I350	R:R:Y215	8.46	No	Yes	0	8	9
191	R:R:F219	R:R:R223	9.62	No	No	0	6	7
192	R:R:F219	R:R:L347	3.65	No	No	0	6	8
193	R:R:R223	R:R:R227	7.46	No	No	4	7	6
194	R:R:E340	R:R:R223	19.77	Yes	No	4	8	7
195	R:R:F224	R:R:R225	4.28	No	No	0	6	7
196	R:R:K228	R:R:R225	4.95	No	No	0	5	7
197	R:R:I226	R:R:R339	5.01	No	No	0	6	7
198	R:R:E340	R:R:I226	5.47	Yes	No	0	8	6
199	R:R:E340	R:R:R227	13.96	Yes	No	4	8	6
200	R:R:E326	R:R:K324	14.85	No	No	0	3	1
201	R:R:K324	R:R:R327	3.71	No	No	0	1	3
202	R:R:E330	R:R:R333	5.82	No	No	5	4	4
203	R:R:E330	R:R:K334	4.05	No	No	5	4	5
204	R:R:K332	R:R:M335	4.32	No	No	0	6	4
205	R:R:K334	R:R:R333	7.43	No	No	5	5	4
206	R:R:L337	R:R:R333	6.07	No	No	0	5	4
207	R:R:M335	R:R:R339	16.13	No	No	0	4	7
208	R:R:I349	R:R:K345	5.82	No	No	0	7	7
209	R:R:I349	R:R:I399	4.42	No	Yes	0	7	8
210	R:R:I350	R:R:Y400	3.63	No	Yes	0	8	9
211	R:R:L395	R:R:T353	4.42	No	No	0	6	7
212	R:R:I399	R:R:T353	4.56	Yes	No	0	8	7
213	R:R:F354	R:R:W358	4.01	Yes	Yes	1	9	8
214	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
215	R:R:C357	R:R:N392	9.45	No	No	0	8	9
216	R:R:F362	R:R:W358	7.02	Yes	Yes	1	7	8
217	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
218	R:R:N392	R:R:W358	13.56	No	Yes	0	9	8
219	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
220	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
221	R:R:F361	R:R:F362	13.93	Yes	Yes	1	8	7
222	R:R:F361	R:R:I385	3.77	Yes	No	0	8	6
223	R:R:F361	R:R:N386	7.25	Yes	No	0	8	7
224	R:R:L368	R:R:V364	4.47	No	No	6	4	6
225	R:R:M377	R:R:V364	3.04	Yes	No	6	4	6
226	R:R:L368	R:R:M377	8.48	No	Yes	6	4	4
227	R:R:C371	R:R:C375	5.46	No	No	0	5	4
228	R:R:M377	R:R:P378	6.71	Yes	No	0	4	7
229	R:R:L381	R:R:M377	4.24	No	Yes	0	6	4
230	R:R:I384	R:R:L380	4.28	No	No	0	4	3
231	R:R:W387	R:R:Y390	16.4	Yes	Yes	1	8	8
232	R:R:N392	R:R:N396	9.54	No	Yes	0	9	9
233	R:R:I399	R:R:Y400	3.63	Yes	Yes	0	8	9
234	R:R:F411	R:R:Y402	9.28	No	Yes	0	8	6
235	R:R:D406	R:R:N404	12.12	Yes	No	2	7	9
236	R:R:F407	R:R:N404	13.29	Yes	No	2	8	9
237	R:R:K405	R:R:Q408	9.49	No	No	0	6	9
238	R:R:D406	R:R:F407	7.17	Yes	Yes	2	7	8
239	R:R:K412	R:R:N409	4.2	No	No	0	6	6
240	R:R:L74	R:R:S77	3	No	No	0	8	9
241	R:R:L83	R:R:V51	2.98	No	No	0	8	7
242	R:R:L88	R:R:V87	2.98	No	No	0	6	6
243	R:R:L99	R:R:V98	2.98	No	No	0	5	6
244	R:R:N146	R:R:V145	2.96	No	No	0	5	6
245	R:R:L43	R:R:T39	2.95	No	No	0	7	5
246	R:R:L347	R:R:T343	2.95	No	No	0	8	8
247	R:R:I47	R:R:L90	2.85	No	Yes	0	7	8
248	R:R:I163	R:R:L159	2.85	No	No	0	5	3
249	R:R:G105	R:R:W102	2.81	No	Yes	0	7	9
250	R:R:C56	R:R:F411	2.79	No	No	0	8	8
251	R:R:P397	R:R:Y402	2.78	No	Yes	0	9	6
252	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
253	R:R:A401	R:R:F407	2.77	No	Yes	0	8	8
254	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
255	R:R:F403	R:R:V398	2.62	No	No	0	8	6
256	R:R:F370	R:R:T196	2.59	No	No	0	5	7
257	R:R:F407	R:R:I75	2.51	Yes	No	0	8	8
258	R:R:E372	R:R:H193	2.46	No	No	0	3	4
259	R:R:D192	R:R:Y195	2.3	No	Yes	0	6	8
260	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
261	R:R:A79	R:R:G76	1.95	No	No	0	9	6
262	R:R:G202	R:R:I167	1.76	No	Yes	0	5	8
263	R:R:G202	R:R:I206	1.76	No	No	0	5	6
264	R:R:G382	R:R:I385	1.76	No	No	0	4	6
265	R:R:G382	R:R:M377	1.75	No	Yes	0	4	4
266	R:R:C375	R:R:S374	1.72	No	No	0	4	5
267	R:R:C371	R:R:V367	1.71	No	No	0	5	6
268	R:R:A79	R:R:V58	1.7	No	No	0	9	7
269	R:R:A153	R:R:V70	1.7	No	No	0	7	7
270	R:R:C49	R:R:T45	1.69	No	No	0	5	4
271	R:R:A221	R:R:T139	1.68	No	No	0	6	8
272	R:R:D192	R:R:G194	1.68	No	No	0	6	5
273	R:R:A222	R:R:T343	1.68	No	No	0	8	8
274	R:R:L90	R:R:P91	1.64	Yes	No	0	8	9
275	R:R:L388	R:R:P360	1.64	No	No	0	8	9
276	R:R:S373	R:R:S374	1.63	No	No	0	3	5
277	R:R:A336	R:R:I226	1.62	No	No	0	5	6
278	R:R:C49	R:R:L394	1.59	No	No	0	5	7
279	R:R:A55	R:R:L83	1.58	No	No	0	5	8
280	R:R:A71	R:R:N69	1.56	No	No	0	8	8
281	R:R:I363	R:R:V367	1.54	No	No	0	7	6
282	R:R:I350	R:R:T346	1.52	No	No	0	8	8
283	R:R:F219	R:R:G216	1.51	No	No	0	6	3
284	R:R:L67	R:R:S66	1.5	Yes	No	0	8	6
285	R:R:K342	R:R:T346	1.5	No	No	0	8	8
286	R:R:L115	R:R:V89	1.49	No	Yes	0	5	8
287	R:R:L111	R:R:V107	1.49	No	No	0	5	4
288	R:R:L42	R:R:T45	1.47	No	No	0	5	4
289	R:R:D192	R:R:T177	1.45	No	No	0	6	5
290	R:R:E179	R:R:S182	1.44	No	No	0	3	3
291	R:R:Q106	R:R:V107	1.43	No	No	0	4	4
292	R:R:I163	R:R:L162	1.43	No	No	0	5	5
293	R:R:Q36	R:R:T39	1.42	No	No	0	4	5
294	R:R:I142	R:R:N146	1.42	No	No	0	6	5
295	R:R:G174	R:R:W175	1.41	No	No	0	5	6
296	R:R:D140	R:R:I142	1.4	No	No	0	7	6
297	R:R:K147	R:R:N146	1.4	No	No	0	5	5
298	R:R:K412	R:R:Q408	1.36	No	No	0	6	9
299	R:R:A186	R:R:Y96	1.33	No	No	0	4	6
300	R:R:D183	R:R:D185	1.33	No	No	0	1	4
301	R:R:E340	R:R:L337	1.33	Yes	No	0	8	5
302	R:R:R151	R:R:T149	1.29	No	No	0	6	8
303	R:R:V398	R:R:Y402	1.26	No	Yes	0	6	6
304	R:R:F403	R:R:I399	1.26	No	Yes	0	8	8
305	R:R:F48	R:R:L52	1.22	No	No	0	4	4
306	R:R:L337	R:R:R341	1.21	No	No	0	5	6
307	R:R:R217	R:R:R220	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.35545	11	1	0
2	R:R:E64	6.19	4	2	7
3	R:R:L67	5.13167	6	2	8
4	R:R:N72	8.21	4	2	9
5	R:R:L78	6.235	6	1	9
6	R:R:D82	6.652	5	1	9
7	R:R:V89	3.27	4	1	8
8	R:R:L90	3.882	5	1	8
9	R:R:W102	8.64833	6	3	9
10	R:R:T121	4.65	4	1	8
11	R:R:S122	8.0775	4	1	8
12	R:R:H126	7.17571	7	1	8
13	R:R:L127	6.16	4	1	8
14	R:R:Y135	7.672	5	0	9
15	R:R:W161	8.318	5	1	9
16	R:R:I167	3.8575	4	0	8
17	R:R:R176	8.3075	4	0	6
18	R:R:C187	5.9425	4	3	9
19	R:R:Y195	8.71	5	0	8
20	R:R:F204	9.96	5	1	8
21	R:R:Y205	5.5775	4	1	7
22	R:R:Y215	5.885	6	0	9
23	R:R:E340	10.1325	4	4	8
24	R:R:F354	5.03667	6	1	9
25	R:R:W358	8.23857	7	1	8
26	R:R:L359	5.1975	4	0	7
27	R:R:F361	8.918	5	1	8
28	R:R:F362	10.01	6	1	7
29	R:R:M377	4.844	5	6	4
30	R:R:W387	9.16	5	1	8
31	R:R:Y390	8.34333	6	1	8
32	R:R:N396	9.5525	4	1	9
33	R:R:I399	3.4675	4	0	8
34	R:R:Y400	4.98	6	1	9
35	R:R:Y402	4.544	5	0	6
36	R:R:D406	7.1875	4	2	7
37	R:R:F407	7.17429	7	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	83.7064	11.96	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	73.646	16.4	Yes	Yes	1	8	8
3	R:R:L43	R:R:W387	65.2738	17.08	No	Yes	0	7	8
4	R:R:L43	R:R:T39	60.9121	2.95	No	No	0	7	5
5	R:R:T39	R:R:V98	54.1059	3.17	No	No	0	5	6
6	R:R:L90	R:R:Y390	22.9776	5.86	Yes	Yes	1	8	8
7	R:R:L90	R:R:S86	15.4839	4.5	Yes	No	0	8	8
8	R:R:A50	R:R:S86	12.9402	3.42	No	No	0	8	8
9	R:R:A50	R:R:L394	10.3812	3.15	No	No	0	8	7
10	R:R:C119	R:R:V89	33.3282	3.42	No	Yes	0	7	8
11	R:R:C119	R:R:M84	24.9561	3.24	No	No	0	7	7
12	R:R:L88	R:R:M84	10.2513	5.65	No	No	0	6	7
13	R:R:V89	R:R:Y390	29.8449	3.79	Yes	Yes	1	8	8
14	L:L:?1	R:R:C120	31.5713	4.63	Yes	No	1	0	7
15	R:R:C120	R:R:V85	34.5428	3.42	No	No	0	7	8
16	R:R:C119	R:R:V85	20.7853	3.42	No	No	0	7	8
17	R:R:S393	R:R:V85	40.2949	4.85	No	No	0	9	8
18	R:R:D82	R:R:S393	40.356	4.42	Yes	No	0	9	9
19	R:R:D82	R:R:N54	100	6.73	Yes	No	0	9	9
20	R:R:L83	R:R:N54	13.368	4.12	No	No	0	8	9
21	L:L:?1	R:R:W358	97.5632	4.15	Yes	Yes	1	0	8
22	R:R:N392	R:R:W358	49.026	13.56	No	Yes	0	9	8
23	R:R:N392	R:R:N396	47.2844	9.54	No	Yes	0	9	9
24	R:R:D82	R:R:N396	44.5115	8.08	Yes	Yes	1	9	9
25	R:R:N54	R:R:P397	85.7918	6.52	No	No	0	9	9
26	R:R:P397	R:R:Y402	82.1328	2.78	No	Yes	0	9	6
27	R:R:F411	R:R:Y402	20.6554	9.28	No	Yes	0	8	6
28	R:R:C56	R:R:F411	12.436	2.79	No	No	0	8	8
29	R:R:V57	R:R:Y402	84.2105	5.05	No	Yes	0	9	6
30	R:R:A79	R:R:V57	16.5534	3.39	No	No	0	9	9
31	R:R:A401	R:R:V57	64.7697	5.09	No	No	0	8	9
32	R:R:A401	R:R:F407	60.8357	2.77	No	Yes	0	8	8
33	R:R:F407	R:R:L67	28.5998	8.53	Yes	Yes	2	8	8
34	R:R:E64	R:R:L67	16.5534	5.3	Yes	Yes	2	7	8
35	R:R:F407	R:R:N72	12.2527	9.67	Yes	Yes	2	8	9
36	R:R:F354	R:R:W358	66.2287	4.01	Yes	Yes	1	9	8
37	R:R:F354	R:R:L127	65.778	3.65	Yes	Yes	1	9	8
38	R:R:L127	R:R:L78	31.2276	4.15	Yes	Yes	1	8	9
39	R:R:H126	R:R:L78	63.4405	7.71	Yes	Yes	1	8	9
40	R:R:H126	R:R:S77	47.6587	5.58	Yes	No	1	8	9
41	R:R:L74	R:R:S77	44.6948	3	No	No	0	8	9
42	R:R:D133	R:R:L74	35.3678	5.43	No	No	0	9	8
43	R:R:D133	R:R:R148	32.2282	11.91	No	No	0	9	8
44	R:R:R148	R:R:V70	22.7179	14.38	No	No	0	8	7
45	R:R:P150	R:R:V70	16.3013	3.53	No	No	0	5	7
46	R:R:L78	R:R:N396	13.0319	9.61	Yes	Yes	1	9	9
47	R:R:I130	R:R:L78	14.4603	4.28	No	Yes	1	9	9
48	R:R:L127	R:R:Y400	25.0783	5.86	Yes	Yes	1	8	9
49	R:R:M84	R:R:W161	19.7693	4.65	No	Yes	0	7	9
50	R:R:L99	R:R:V98	49.492	2.98	No	No	0	5	6
51	R:R:L95	R:R:L99	32.4574	5.54	No	No	0	6	5
52	R:R:L104	R:R:L95	30.0435	4.15	No	No	0	7	6
53	R:R:L104	R:R:W102	25.2158	21.64	No	Yes	0	7	9
54	R:R:L99	R:R:T103	15.0791	4.42	No	No	0	5	5
55	R:R:K101	R:R:T103	12.5506	4.5	No	No	0	5	5
56	R:R:D185	R:R:K101	10.0985	9.68	No	No	0	4	5
57	L:L:?1	R:R:S199	50.2865	8.75	Yes	No	0	0	8
58	R:R:S199	R:R:Y195	47.9719	13.99	No	Yes	0	8	8
59	R:R:S190	R:R:Y195	20.3269	3.82	No	Yes	0	6	8
60	R:R:R176	R:R:S190	17.829	5.27	Yes	No	0	6	6
61	L:L:?1	R:R:V117	16.0034	11.94	Yes	No	0	0	8
62	R:R:I167	R:R:V117	11.3589	3.07	Yes	No	0	8	8
63	L:L:?1	R:R:T121	16.0186	5.37	Yes	Yes	1	0	8
64	R:R:I167	R:R:T121	11.3437	4.56	Yes	Yes	0	8	8
65	R:R:I124	R:R:W358	13.1312	15.27	No	Yes	1	8	8
66	R:R:I124	R:R:P207	25.0707	3.39	No	No	0	8	9
67	R:R:P207	R:R:W125	20.6096	16.21	No	No	0	9	7
68	R:R:R134	R:R:Y400	25.8269	7.2	No	Yes	1	9	9
69	R:R:F354	R:R:M211	57.5739	7.46	Yes	No	0	9	9
70	R:R:M211	R:R:Y215	55.076	5.99	No	Yes	0	9	9
71	R:R:R134	R:R:Y215	37.3997	7.2	No	Yes	0	9	9
72	R:R:I218	R:R:Y215	57.8107	3.63	No	Yes	0	9	9
73	R:R:I218	R:R:Y135	55.16	4.84	No	Yes	0	9	9
74	R:R:W136	R:R:Y135	29.6922	3.86	No	Yes	0	5	9
75	R:R:R152	R:R:W136	24.9255	7	No	No	0	7	5
76	R:R:D143	R:R:R152	21.9617	10.72	No	No	0	6	7
77	R:R:I163	R:R:W125	11.6645	15.27	No	No	0	5	7
78	R:R:I167	R:R:Y198	15.4534	6.04	Yes	No	0	8	5
79	R:R:D192	R:R:Y195	15.3923	2.3	No	Yes	0	6	8
80	R:R:D192	R:R:T177	10.3201	1.45	No	No	0	6	5
81	L:L:?1	R:R:F362	19.4179	11.54	Yes	Yes	1	0	7
82	R:R:F362	R:R:Y205	11.6798	3.09	Yes	Yes	1	7	7
83	R:R:F201	R:R:Y205	23.3366	7.22	No	Yes	0	5	7
84	R:R:F201	R:R:I197	20.4721	5.02	No	No	0	5	7
85	R:R:F370	R:R:I197	17.5922	5.02	No	No	0	5	7
86	R:R:F204	R:R:F362	20.4874	19.29	Yes	Yes	1	8	7
87	R:R:F204	R:R:L359	27.1102	6.09	Yes	Yes	0	8	7
88	R:R:L347	R:R:Y215	52.3948	4.69	No	Yes	0	8	9
89	R:R:I350	R:R:Y400	29.5776	3.63	No	Yes	0	8	9
90	R:R:I350	R:R:Y215	28.6151	8.46	No	Yes	0	8	9
91	R:R:F219	R:R:L347	43.9844	3.65	No	No	0	6	8
92	R:R:F219	R:R:R223	38.3011	9.62	No	No	0	6	7
93	R:R:E340	R:R:R223	32.4651	19.77	Yes	No	4	8	7
94	R:R:E340	R:R:I226	15.0485	5.47	Yes	No	0	8	6
95	R:R:E340	R:R:L337	15.0791	1.33	Yes	No	0	8	5
96	R:R:I399	R:R:Y400	43.3122	3.63	Yes	Yes	0	8	9
97	R:R:I363	R:R:L359	16.4464	7.14	No	Yes	0	7	7
98	L:L:?1	R:R:F361	23.9783	16.87	Yes	Yes	1	0	8
99	R:R:F361	R:R:I385	31.1664	3.77	Yes	No	0	8	6
100	R:R:G382	R:R:I385	26.7588	1.76	No	No	0	4	6
101	R:R:G382	R:R:M377	22.336	1.75	No	Yes	0	4	4
102	R:R:I363	R:R:V367	13.7423	1.54	No	No	0	7	6
103	R:R:C371	R:R:V367	11.0228	1.71	No	No	0	5	6
104	R:R:F403	R:R:I399	32.9616	1.26	No	Yes	0	8	8
105	R:R:F403	R:R:V398	30.9296	2.62	No	No	0	8	6
106	R:R:H126	R:R:W161	17.1034	4.23	Yes	Yes	1	8	9
107	R:R:F362	R:R:W358	20.7929	7.02	Yes	Yes	1	7	8
108	R:R:D82	R:R:L78	26.9269	8.14	Yes	Yes	1	9	9
109	R:R:F204	R:R:F354	41.0053	6.43	Yes	Yes	1	8	9
110	R:R:V398	R:R:Y402	29.0887	1.26	No	Yes	0	6	6
111	R:R:F361	R:R:F362	20.3117	13.93	Yes	Yes	1	8	7
112	R:R:L127	R:R:N396	11.4353	10.98	Yes	Yes	1	8	9
113	R:R:L78	R:R:Y400	27.0415	3.52	Yes	Yes	1	9	9
114	R:R:F354	R:R:I124	14.6207	5.02	Yes	No	1	9	8
115	R:R:I130	R:R:R134	12.2298	5.01	No	No	1	9	9
116	R:R:F204	R:R:Y205	15.8888	8.25	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D116	13.85	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	11.94	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	4.63	1	Yes	No	0	7	0	1
L:L:?1	R:R:T121	5.37	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I189	10.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:S199	8.75	1	Yes	No	0	8	0	1
L:L:?1	R:R:A203	3.45	1	Yes	No	0	8	0	1
L:L:?1	R:R:W358	4.15	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	16.87	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	11.54	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y390	11.96	1	Yes	Yes	0	8	0	1
R:R:C120	R:R:V85	3.42	1	No	No	7	8	1	2
R:R:D116	R:R:V89	4.38	1	No	Yes	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	Yes	Yes	8	8	2	1
R:R:L90	R:R:W387	4.56	1	Yes	Yes	8	8	2	2
R:R:L90	R:R:Y390	5.86	1	Yes	Yes	8	8	2	1
R:R:A93	R:R:Y390	4	0	No	Yes	7	8	2	1
R:R:D116	R:R:Y390	8.05	1	No	Yes	8	8	1	1
R:R:I167	R:R:V117	3.07	0	Yes	No	8	8	2	1
R:R:S168	R:R:V117	4.85	0	No	No	8	8	2	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	1
R:R:G164	R:R:T121	3.64	0	No	Yes	8	8	2	1
R:R:I167	R:R:T121	4.56	0	Yes	Yes	8	8	2	1
R:R:A203	R:R:T121	5.03	1	No	Yes	8	8	1	1
R:R:F354	R:R:I124	5.02	1	Yes	No	9	8	2	2
R:R:I124	R:R:W358	15.27	1	No	Yes	8	8	2	1
R:R:S199	R:R:Y195	13.99	0	No	Yes	8	8	1	2
R:R:T200	R:R:Y205	3.75	1	No	Yes	7	7	2	2
R:R:F362	R:R:T200	5.19	1	Yes	No	7	7	1	2
R:R:F204	R:R:Y205	8.25	1	Yes	Yes	8	7	2	2
R:R:F204	R:R:F354	6.43	1	Yes	Yes	8	9	2	2
R:R:F204	R:R:F362	19.29	1	Yes	Yes	8	7	2	1
R:R:F362	R:R:Y205	3.09	1	Yes	Yes	7	7	1	2
R:R:F354	R:R:W358	4.01	1	Yes	Yes	9	8	2	1
R:R:F362	R:R:W358	7.02	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	8.44	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	13.56	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	13.93	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:I385	3.77	1	Yes	No	8	6	1	2
R:R:F361	R:R:N386	7.25	1	Yes	No	8	7	1	2
R:R:W387	R:R:Y390	16.4	1	Yes	Yes	8	8	2	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FY8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	263
Number of Links	307
Number of Hubs	37
Number of Links mediated by Hubs	151
Number of Communities	6
Number of Nodes involved in Communities	53
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	117
Number Of Links MetaPath	116
Number of Shortest Paths	53248
Length Of Smallest Path	3
Average Path Length	11.9752
Length of Longest Path	26
Minimum Path Strength	1.27
Average Path Strength	6.41461
Maximum Path Strength	16.74
Minimum Path Correlation	0.7
Average Path Correlation	0.936267
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.66667
Average % Of Corr. Nodes	62.598
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2484
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • periplasmic space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YFW
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YFW
Name	5-methoxy-N,N-dimethyltryptamine
Synonyms	5-MeO-DMT
Identifier
Formula	C13 H18 N2 O
Molecular Weight	218.295
SMILES
PubChem	1832
Formal Charge	0
Total Atoms	34
Total Chiral Atoms	0
Total Bonds	35
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>8FY8_nogp_Chain_R Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I W H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R T P E D R S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	-		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	-		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	-		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	-		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	-		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	-		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	-		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	-		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851

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