Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L44 7.88549
2A:A:L46 4.215448
3A:A:K53 5.385489
4A:A:F219 7.05167608
5A:A:F222 9.784547
6A:A:K233 5.904519
7A:A:W234 5.285419
8A:A:I244 3.834548
9A:A:V247 3.6175487
10A:A:S252 3.974228
11A:A:Y253 5.205638
12A:A:F273 5.44549
13A:A:W277 9.385446
14A:A:W281 12.4565105
15A:A:L289 4.3525409
16A:A:F290 8.6825489
17A:A:N292 5.015489
18A:A:K293 4.62409
19A:A:Q294 7.1275436
20A:A:Y311 6.215436
21A:A:F312 4.5875438
22A:A:E314 5.285436
23A:A:F315 12.265406
24A:A:P321 5.162535
25A:A:E330 4.1575403
26A:A:D331 8.525404
27A:A:V334 3.4275404
28A:A:Y339 7.184533
29A:A:F340 11.126537
30A:A:R342 6.762534
31A:A:E344 8.4025435
32A:A:F345 8.105408
33A:A:S349 4.2925407
34A:A:R356 5.895402
35A:A:F363 10.084535
36A:A:T364 7.8275489
37A:A:D368 8.31489
38A:A:N371 7.23167689
39A:A:R374 10.074584
40A:A:F376 6.0325408
41A:A:R385 7.90254165
42B:B:L14 4.78408
43B:B:I18 4.03427
44B:B:R22 6.76426
45B:B:L30 4.4175475
46B:B:I37 2.34402
47B:B:V40 5.3825493
48B:B:H54 7.991676139
49B:B:K57 14.41754109
50B:B:W63 7.01667657
51B:B:V71 4.7954128
52B:B:D76 7.2025219
53B:B:K78 6.115408
54B:B:I80 8.70254138
55B:B:W82 10.6665139
56B:B:S84 4.5775455
57B:B:Y85 7.75454
58B:B:N88 7.3675407
59B:B:K89 6.56139
60B:B:L95 4.3654128
61B:B:W99 10.206549
62B:B:M101 5.6775409
63B:B:Y111 5.986514
64B:B:V112 4.3854128
65B:B:C121 3.34418
66B:B:Y124 4.648577126
67B:B:L139 6.4409
68B:B:H142 8.9925419
69B:B:Y145 7.145618
70B:B:C149 3.475418
71B:B:F151 4.91667619
72B:B:T159 5.89619
73B:B:D163 9.5725419
74B:B:C166 4.0475468
75B:B:L168 5.395466
76B:B:W169 10.9583618
77B:B:T173 6.52754195
78B:B:F180 8.418567
79B:B:H183 8.41667669
80B:B:D186 5.965419
81B:B:V187 5.024569
82B:B:V200 6.176526
83B:B:S201 4.915469
84B:B:C204 5.19667617
85B:B:D205 6.8025469
86B:B:K209 11.6225466
87B:B:W211 9.59833668
88B:B:F222 6.475428
89B:B:H225 7.57571729
90B:B:D228 10.53419
91B:B:I229 5.9975427
92B:B:I232 5.4775428
93B:B:F234 7.4075425
94B:B:F235 6.758336206
95B:B:F241 6.775626
96B:B:T243 6.315428
97B:B:D247 7.5275429
98B:B:R251 8.654528
99B:B:F253 5.82667626
100B:B:D254 4.2275409
101B:B:D258 7.518527
102B:B:E260 6.7675426
103B:B:M262 6.2175474
104B:B:Y264 7.634575
105B:B:H266 9.0875474
106B:B:I273 6.12406
107B:B:R283 8.786599
108B:B:L284 4.9925405
109B:B:Y289 6.86286777
110B:B:C294 4.2954145
111B:B:N295 7.555476
112B:B:W297 6.6875478
113B:B:D298 10.3925499
114B:B:R304 8.765475
115B:B:H311 8.376149
116B:B:R314 13.9845108
117B:B:V315 4.0454147
118B:B:T321 7.14457
119B:B:W332 15.5585109
120B:B:D333 8.23754149
121B:B:K337 7.74406
122G:G:I25 4.66422
123G:G:R27 4.746528
124G:G:Y40 7.78754206
125G:G:D48 6.93699
126G:G:L50 4.92499
127G:G:L51 6.104596
128G:G:N59 4.76559
129G:G:P60 7.1125459
130G:G:F61 6.17667658
131R:R:L144 3.83406
132R:R:Y152 7.225407
133R:R:R176 6.248336119
134R:R:H180 5.794119
135R:R:F184 4.535408
136R:R:F187 7.97408
137R:R:Y220 4.4125403
138R:R:Q221 2.884284
139R:R:Y242 5.5025186
140R:R:W243 11.645279
141R:R:E247 8.4675409
142R:R:Y250 8.355118
143R:R:L255 4.25254118
144R:R:Y269 5.63407
145R:R:W274 9.04754279
146R:R:W284 5.526676298
147R:R:E294 10.93754284
148R:R:W297 8.9625408
149R:R:F321 6.595406
150R:R:F324 7.545179
151R:R:K334 7.674169
152R:R:P358 3.3875409
153R:R:L360 3.84254179
154R:R:T362 5.4654177
155R:R:H363 10.8285158
156R:R:F367 5.388336157
157R:R:L388 5.7725407
158R:R:F393 4.3554257
159R:R:C403 4.73409
160R:R:W420 6.2554304
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:S74 13.149910.31YesNo099
2B:B:H54 B:B:S74 12.998512.55YesNo099
3A:A:Y37 B:B:D76 17.96023.45NoYes2149
4A:A:R42 A:A:Y37 18.897519.55NoNo094
5A:A:F222 A:A:R42 19.05127.48YesNo079
6A:A:F222 A:A:F238 19.41324.29YesNo479
7A:A:F238 A:A:L44 76.724619.49NoYes499
8A:A:I244 A:A:L44 87.82555.71YesYes489
9A:A:I244 A:A:V287 99.57393.07YesNo486
10A:A:F273 A:A:V287 84.99695.24YesNo496
11A:A:F273 A:A:F345 42.55517.5YesYes098
12A:A:F345 A:A:L270 42.67149.74YesNo086
13A:A:E344 A:A:L270 85.43513.98YesNo056
14A:A:E314 A:A:E344 28.51046.34YesYes365
15A:A:E314 A:A:F312 28.4915.83YesYes368
16A:A:F312 A:A:L266 56.92443.65YesNo088
17A:A:L266 A:A:Y253 56.84364.69NoYes088
18A:A:K300 A:A:Y253 99.98234.78NoYes398
19A:A:K300 A:A:S251 1004.59NoNo099
20A:A:L296 A:A:S251 99.91333NoNo069
21A:A:K293 A:A:L296 99.82657.05YesNo096
22A:A:K293 A:A:N292 98.7826.99YesYes099
23A:A:N292 A:A:V247 33.0074.43YesYes897
24A:A:F290 A:A:V247 32.00423.93YesYes897
25A:A:F290 A:A:H362 63.74565.66YesNo099
26A:A:D378 A:A:H362 95.312910.08NoNo079
27A:A:D378 A:A:Y360 93.724314.94NoNo078
28A:A:D381 A:A:Y360 92.77058.05NoNo088
29A:A:D381 R:R:K334 91.154911.06NoYes1689
30A:A:F273 A:A:I348 42.52735.02YesNo094
31A:A:I348 A:A:L270 42.73554.28NoNo046
32A:A:E344 A:A:F340 56.992111.66YesYes357
33A:A:F312 A:A:F340 28.55585.36YesYes387
34A:A:F315 A:A:F340 28.586921.43YesYes067
35A:A:F315 A:A:I308 28.557311.3YesNo067
36A:A:I308 A:A:Y253 28.54768.46NoYes078
37A:A:V287 A:A:W277 14.7114.9NoYes466
38A:A:S349 A:A:W277 14.74987.41YesYes076
39A:A:L346 A:A:S349 14.78213NoYes047
40A:A:L346 A:A:R342 14.77357.29NoYes344
41A:A:F363 A:A:R342 14.69246.41YesYes354
42A:A:F363 A:A:Q294 14.61599.37YesYes356
43A:A:L297 A:A:Q294 14.90225.32NoYes386
44A:A:L297 A:A:Y253 14.92953.52NoYes388
45A:A:N292 A:A:T364 65.04234.39YesYes899
46A:A:F290 A:A:T364 31.93514.27YesYes899
47A:A:R374 A:A:T364 32.47493.88YesYes849
48A:A:H362 A:A:R374 31.886415.8NoYes094
49B:B:Q75 B:B:W99 57.61666.57NoYes099
50B:B:Q75 B:B:Y59 47.61163.38NoNo098
51B:B:M101 B:B:Y59 47.31717.18YesNo098
52B:B:M101 B:B:Y145 45.997.18YesYes098
53B:B:S316 B:B:W332 10.08124.94NoYes099
54A:A:W281 B:B:R314 10.186318.99YesYes1058
55B:B:K57 B:B:W332 10.680430.17YesYes1099
56A:A:N279 A:A:W281 21.20295.65NoYes085
57A:A:I235 A:A:L44 11.06371.43NoYes499
58A:A:I235 A:A:L282 21.7971.43NoNo099
59A:A:L394 R:R:K334 85.12612.82NoYes089
60A:A:L388 A:A:L394 77.99174.15NoNo088
61A:A:L388 R:R:L255 54.94775.54NoYes088
62R:R:L251 R:R:L255 53.00874.15NoYes1198
63A:A:Y391 R:R:L251 52.69165.86NoNo1149
64A:A:Y391 R:R:R176 47.81588.23NoYes1149
65R:R:R176 R:R:Y250 29.10894.12YesYes1198
66A:A:L388 A:A:L393 22.7634.15NoNo088
67A:A:L393 R:R:L356 21.79686.92NoNo089
68B:B:G162 B:B:Y145 41.32225.79NoYes198
69B:B:G162 B:B:S161 41.2453.71NoNo199
70B:B:H142 B:B:S161 40.320512.55YesNo199
71B:B:H142 B:B:T159 35.54385.48YesYes199
72B:B:C149 B:B:T159 32.69833.38YesYes189
73B:B:C149 B:B:T102 32.45225.07YesNo088
74B:B:C148 B:B:T102 32.30083.38NoNo068
75B:B:C148 B:B:L190 31.39164.76NoNo065
76B:B:L190 B:B:S160 31.23997.51NoNo056
77B:B:S160 B:B:V187 24.05826.46NoYes669
78B:B:H183 B:B:V187 22.34626.92YesYes699
79B:B:H183 B:B:K209 20.962115.72YesYes696
80B:B:K209 B:B:T221 20.24799.01YesNo067
81B:B:T221 G:G:E22 20.09415.64NoNo079
82B:B:D258 G:G:E22 19.94036.5YesNo079
83B:B:D258 B:B:R22 14.704513.1YesYes276
84B:B:Q259 B:B:R22 10.16464.67NoYes066
85B:B:S275 B:B:T274 19.22564.8NoNo088
86B:B:L318 B:B:S275 18.62253NoNo068
87B:B:L318 B:B:S277 18.02033NoNo065
88B:B:L284 B:B:V296 14.45645.96YesNo055
89B:B:L286 B:B:V296 15.6355.96NoNo075
90B:B:L286 B:B:V327 16.22624.47NoNo076
91B:B:V320 B:B:V327 16.82328.02NoNo076
92B:B:S277 B:B:V320 17.42084.85NoNo057
93R:R:C174 R:R:R176 15.77795.57NoYes089
94R:R:C174 R:R:N177 15.45046.3NoNo089
95R:R:L166 R:R:N177 14.79725.49NoNo089
96R:R:C403 R:R:L166 13.79413.17YesNo098
97R:R:C403 R:R:F404 11.85645.59YesNo098
98R:R:F404 R:R:I400 11.19933.77NoNo086
99R:R:I400 R:R:L396 10.54195.71NoNo067
100R:R:F324 R:R:L356 14.95957.31YesNo1799
101R:R:Y250 R:R:Y269 25.58648.94YesYes087
102R:R:V246 R:R:Y269 22.97463.79NoYes087
103R:R:I272 R:R:V246 19.09383.07NoNo068
104R:R:I272 R:R:V276 18.11654.61NoNo063
105R:R:V276 R:R:Y242 16.80357.57NoYes036
106R:R:F280 R:R:Y242 14.50118.25NoYes1856
107R:R:F280 R:R:V281 14.17542.62NoNo056
108R:R:I309 R:R:V281 13.84663.07NoNo076
109R:R:I309 R:R:W284 11.87348.22NoYes078
110R:R:L231 R:R:W284 10.22785.69NoYes058
111B:B:K57 B:B:Q75 11.150512.2YesNo099
112A:A:L282 A:A:N279 21.49229.61NoNo098
113A:A:I244 A:A:L46 11.3314.28YesYes488
114A:A:F238 B:B:W99 57.173910.02NoYes499
115A:A:I235 A:A:L46 11.03851.43NoYes498
116A:A:W281 B:B:D290 10.15166.7YesNo1056
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WG7
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.54
Date 2024-03-06
D.O.I. 10.1038/s41421-024-00649-0
Net Summary
Imin 3
Number of Linked Nodes 854
Number of Links 1017
Number of Hubs 160
Number of Links mediated by Hubs 580
Number of Communities 30
Number of Nodes involved in Communities 246
Number of Links involved in Communities 340
Path Summary
Number Of Nodes in MetaPath 117
Number Of Links MetaPath 116
Number of Shortest Paths 4763045
Length Of Smallest Path 3
Average Path Length 47.4446
Length of Longest Path 92
Minimum Path Strength 1.285
Average Path Strength 6.69154
Maximum Path Strength 29.08
Minimum Path Correlation 0.71
Average Path Correlation 0.991432
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 26.9637
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.5249
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • binding   • peptide hormone binding   • hormone binding   • glucagon-like peptide 1 receptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • heart process   • multicellular organismal process   • system process   • regulation of biological process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • regulation of blood pressure   • positive regulation of blood pressure   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • nervous system process   • cognition   • transport   • secretion   • regulation of hormone levels   • cell-cell signaling   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • protein localization   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • cellular macromolecule localization   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • establishment of protein localization to endoplasmic reticulum   • protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein localization to membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • protein localization to organelle   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of smell   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • amide transport   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • regulation of protein transport   • peptide transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • cytoskeletal protein binding   • spectrin binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • cell population proliferation   • phospholipase C-activating G protein-coupled receptor signaling pathway   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • cell projection membrane   • synapse   • cell junction   • cell body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8WG7_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG AGESGKNTI 
VKQMRILHI FETKFQVDK VNFHMFDVG AQRDERRKW IQCFNDVTA 
IIFVVASSS YTNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>8WG7_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>8WG7_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>8WG7_Chain_R
SPEEQLLFL YIIYTVGYA LSFSALVIA SAILLGFRH LHCTRNYIH 
LNLFASFIL RALSVFIKD AALKWMYST SYQDSLSCR LVFLLMQYC 
VAANYYWLL VEGVYLYTL LAFSVLSEQ WIFRLYVSI GWGVPLLFV 
VPWGIVKYL YEDEGCWTR NSNMNYWLI IRLPILFAI GVNFLIFVR 
VICIVVSKL KANLMCKTD IKCRLAKST LTLIPLLGT HEVIFAFVM 
DEHARGTLR FIKLFTELS FTSFQGLMV AILYCFVNN EVQLEFRKS 
WERWRLEH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-1310.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-1310.1016/j.apsb.2024.09.002
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-0610.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-0610.1038/s41421-024-00649-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-0810.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-0810.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-0610.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-0610.1073/pnas.2303696120
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-0610.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-0610.1073/pnas.2303696120
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-2710.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-2710.1016/j.apsb.2024.09.002
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-2610.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-2610.1021/jacs.4c12808
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-2910.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-2910.1073/pnas.2200155119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-2910.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-2910.1073/pnas.2200155119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-1310.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-1310.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-1310.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-1310.1073/pnas.2116506119
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-0610.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-0210.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-0210.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-1210.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-1210.1038/s41467-021-27760-0
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-1210.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-1210.1038/s41467-021-27760-0
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-0510.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-0510.1038/s41589-021-00945-w
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-0510.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-0510.1038/s41589-021-00945-w
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-0610.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-0610.1016/j.bbrc.2021.09.016
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-1110.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-1110.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-1110.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-1110.1038/s41467-021-24058-z
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-1410.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-1410.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-0710.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-0710.1038/s41467-021-24058-z
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-2010.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-2010.1016/j.str.2021.04.008
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-1810.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-1810.1073/pnas.2014879117
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-0910.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-0910.1016/j.molcel.2020.09.020
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-0910.1016/j.molcel.2020.09.020
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-2610.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-2610.1038/s41422-020-0384-8
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-2210.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-2210.1038/s41589-020-0589-7
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-0810.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-0810.1038/s41586-019-1902-z
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-2110.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-2110.1038/nature25773
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-2410.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-2410.1038/nature22394
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378




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