psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E34	R:R:V30	5.7	No	No	0	4	2
2	R:R:E34	R:R:S31	10.06	No	No	0	4	4
3	R:R:L32	R:R:Y205	7.03	No	No	0	4	3
4	R:R:Q221	R:R:W33	16.43	No	No	0	4	3
5	R:R:W33	W:W:?1	13.49	No	Yes	0	3	0
6	R:R:P90	R:R:T35	8.74	No	No	0	4	5
7	R:R:V36	R:R:W214	9.81	No	Yes	0	2	1
8	R:R:L217	R:R:V36	4.47	No	No	0	4	2
9	R:R:Q221	R:R:Q37	7.68	No	No	0	4	4
10	R:R:K38	R:R:W87	8.12	No	No	0	4	3
11	R:R:R43	R:R:W39	5	Yes	Yes	1	4	5
12	R:R:E68	R:R:W39	9.81	No	Yes	1	4	5
13	R:R:W39	R:R:Y88	15.43	Yes	Yes	1	5	5
14	R:R:W214	R:R:W39	11.25	Yes	Yes	1	1	5
15	R:R:R40	R:R:R44	12.79	No	No	0	2	3
16	R:R:L218	R:R:R40	15.79	No	No	0	3	2
17	R:R:E41	R:R:Q45	11.47	No	No	0	4	5
18	R:R:F66	R:R:Y42	4.13	Yes	Yes	1	7	6
19	R:R:C71	R:R:Y42	8.06	No	Yes	1	9	6
20	R:R:P86	R:R:Y42	8.34	No	Yes	1	8	6
21	R:R:W87	R:R:Y42	4.82	No	Yes	0	3	6
22	R:R:Y42	R:R:Y88	6.95	Yes	Yes	1	6	5
23	R:R:F66	R:R:R43	6.41	Yes	Yes	1	7	4
24	R:R:E68	R:R:R43	10.47	No	Yes	1	4	4
25	R:R:L218	R:R:R43	7.29	No	Yes	0	3	4
26	R:R:Q45	R:R:R48	10.51	No	No	0	5	4
27	R:R:C46	R:R:F66	5.59	No	Yes	1	8	7
28	R:R:C46	R:R:C71	7.28	No	No	1	8	9
29	R:R:L50	R:R:S49	4.5	No	No	0	4	2
30	R:R:L50	R:R:R64	14.58	No	Yes	0	4	4
31	R:R:E52	R:R:T51	5.64	No	No	0	2	4
32	R:R:D53	R:R:R64	22.63	No	Yes	2	3	4
33	R:R:D53	R:R:D74	3.99	No	Yes	2	3	3
34	R:R:F61	R:R:P56	11.56	No	Yes	0	3	1
35	R:R:D74	R:R:P56	17.71	Yes	Yes	0	3	1
36	R:R:E76	R:R:P56	4.72	No	Yes	0	1	1
37	R:R:F61	R:R:P77	10.11	No	No	0	3	4
38	R:R:C104	R:R:C62	7.28	No	No	0	9	9
39	R:R:P73	R:R:R64	7.21	No	Yes	0	5	4
40	R:R:D74	R:R:R64	7.15	Yes	Yes	2	3	4
41	R:R:D67	R:R:T65	4.34	No	No	0	9	5
42	R:R:E68	R:R:F66	12.83	No	Yes	1	4	7
43	R:R:C71	R:R:F66	5.59	No	Yes	1	9	7
44	R:R:D67	R:R:W72	5.58	No	Yes	1	9	9
45	R:R:D67	R:R:R121	15.48	No	Yes	1	9	6
46	R:R:Y69	R:R:Y88	3.97	Yes	Yes	1	6	5
47	R:R:R121	R:R:Y69	9.26	Yes	Yes	1	6	6
48	R:R:L123	R:R:Y69	12.89	No	Yes	0	5	6
49	R:R:H212	R:R:Y69	6.53	No	Yes	1	3	6
50	R:R:A70	R:R:W72	3.89	No	Yes	0	5	9
51	R:R:R102	R:R:W72	31.99	No	Yes	0	8	9
52	R:R:R121	R:R:W72	6	Yes	Yes	1	6	9
53	R:R:P73	R:R:V81	5.3	No	No	0	5	6
54	R:R:E76	R:R:P77	7.86	No	No	0	1	4
55	R:R:E76	R:R:S79	4.31	No	No	0	1	5
56	R:R:F103	R:R:G78	6.02	Yes	No	0	4	7
57	R:R:F103	R:R:F80	36.44	Yes	No	0	4	4
58	R:R:V81	R:R:V83	4.81	No	No	0	6	5
59	R:R:H99	R:R:N82	10.2	No	No	0	4	4
60	R:R:H99	R:R:S84	4.18	No	No	0	4	4
61	R:R:C126	R:R:C85	7.28	No	No	0	9	9
62	R:R:P86	R:R:Y88	4.17	No	Yes	1	8	5
63	R:R:L89	R:R:Y88	5.86	No	Yes	0	5	5
64	R:R:H212	R:R:Y88	6.53	No	Yes	1	3	5
65	R:R:W214	R:R:Y88	3.86	Yes	Yes	1	1	5
66	R:R:L89	R:R:W91	10.25	No	No	0	5	4
67	R:R:S94	R:R:W91	4.94	No	No	0	4	4
68	R:R:E128	R:R:W91	20.72	No	No	0	3	4
69	R:R:S94	R:R:V95	4.85	No	Yes	0	4	5
70	R:R:W120	R:R:Y101	6.75	Yes	No	0	5	5
71	R:R:E125	R:R:Y101	8.98	No	No	0	5	5
72	R:R:F103	R:R:W110	22.05	Yes	No	0	4	9
73	R:R:L109	R:R:Q112	6.65	No	Yes	0	5	3
74	R:R:L111	R:R:W110	35.31	No	No	3	4	9
75	R:R:W110	R:R:W120	21.56	No	Yes	3	9	5
76	R:R:L111	R:R:W120	10.25	No	Yes	3	4	5
77	R:R:Q112	R:R:S116	7.22	Yes	No	0	3	5
78	R:R:L118	R:R:Q112	3.99	No	Yes	0	4	3
79	R:R:P119	R:R:R121	7.21	No	Yes	0	6	6
80	R:R:D122	R:R:W120	8.93	No	Yes	0	7	5
81	R:R:D122	R:R:S124	8.83	No	No	0	7	5
82	R:R:Q140	R:R:S135	11.55	No	No	0	4	1
83	R:R:E139	R:R:S136	4.31	No	No	0	2	1
84	R:R:E138	R:R:E139	19.03	No	No	0	2	2
85	R:R:E138	W:W:?1	7.48	No	Yes	0	2	0
86	R:R:L141	R:R:L144	5.54	No	No	0	5	6
87	R:R:L141	W:W:?1	9.37	No	Yes	0	5	0
88	R:R:F143	R:R:I147	3.77	No	Yes	0	4	6
89	R:R:Y145	R:R:Y148	4.96	No	No	0	5	7
90	R:R:D198	R:R:Y145	12.64	No	No	0	7	5
91	R:R:Y145	W:W:?1	14.55	No	Yes	0	5	0
92	R:R:F385	R:R:I147	7.54	Yes	Yes	0	6	6
93	R:R:V194	R:R:Y148	5.05	No	No	0	7	7
94	R:R:L388	R:R:Y148	9.38	No	No	0	7	7
95	R:R:A191	R:R:Y152	5.34	No	No	0	7	7
96	R:R:V194	R:R:Y152	10.09	No	No	0	7	7
97	R:R:F156	R:R:I188	5.02	No	No	0	7	7
98	R:R:F184	R:R:L159	7.31	No	No	0	8	9
99	R:R:I188	R:R:L159	4.28	No	No	0	7	9
100	R:R:F404	R:R:I161	3.77	No	No	0	8	4
101	R:R:F169	R:R:I165	8.79	No	No	0	7	8
102	R:R:F413	R:R:I165	7.54	No	No	0	5	8
103	R:R:L166	R:R:L172	4.15	Yes	Yes	0	8	9
104	R:R:L166	R:R:N177	6.87	Yes	No	0	8	9
105	R:R:C403	R:R:L166	4.76	No	Yes	0	9	8
106	R:R:L167	R:R:L181	4.15	No	No	0	3	6
107	R:R:E412	R:R:F169	8.16	Yes	No	0	8	7
108	R:R:H173	R:R:R170	11.28	No	No	0	7	8
109	R:R:E412	R:R:H171	13.54	Yes	No	0	8	7
110	R:R:L172	R:R:V409	5.96	Yes	No	0	9	9
111	R:R:E412	R:R:L172	3.98	Yes	Yes	0	8	9
112	R:R:H173	R:R:Y178	13.07	No	No	0	7	6
113	R:R:C174	R:R:R176	4.18	No	Yes	4	8	9
114	R:R:C174	R:R:N177	4.72	No	No	4	8	9
115	R:R:T175	R:R:Y250	6.24	No	Yes	0	7	8
116	R:R:F266	R:R:T175	5.19	Yes	No	0	6	7
117	R:R:N177	R:R:R176	9.64	No	Yes	4	9	9
118	R:R:H180	R:R:R176	4.51	No	Yes	0	9	9
119	R:R:R176	R:R:Y250	4.12	Yes	Yes	0	9	8
120	R:R:F266	R:R:Y178	4.13	Yes	No	0	6	6
121	R:R:E247	R:R:I179	5.47	Yes	No	0	9	8
122	R:R:I179	R:R:Y250	4.84	No	Yes	0	8	8
123	R:R:F266	R:R:I179	5.02	Yes	No	0	6	8
124	R:R:E247	R:R:H180	11.08	Yes	No	0	9	9
125	R:R:H180	R:R:Y402	8.71	No	No	0	9	8
126	R:R:N182	R:R:W243	18.08	No	Yes	5	9	9
127	R:R:N182	R:R:W274	4.52	No	Yes	5	9	9
128	R:R:F187	R:R:L183	6.09	Yes	No	0	8	9
129	R:R:E247	R:R:L183	6.63	Yes	No	0	9	9
130	R:R:F184	R:R:V398	3.93	No	No	0	8	9
131	R:R:N240	R:R:S186	5.96	No	No	0	9	9
132	R:R:S186	R:R:W243	7.41	No	Yes	0	9	9
133	R:R:F187	R:R:N240	16.92	Yes	No	0	8	9
134	R:R:F187	R:R:Q394	9.37	Yes	Yes	0	8	9
135	R:R:F187	R:R:G395	4.52	Yes	No	0	8	9
136	R:R:F187	R:R:V398	3.93	Yes	No	0	8	9
137	R:R:R190	R:R:V237	10.46	Yes	No	0	8	6
138	R:R:N240	R:R:R190	14.46	No	Yes	0	9	8
139	R:R:R190	R:R:Y241	11.32	Yes	No	0	8	8
140	R:R:R190	R:R:T391	3.88	Yes	No	0	8	6
141	R:R:I196	R:R:L192	7.14	No	No	0	5	3
142	R:R:M233	R:R:S193	7.67	No	No	0	6	6
143	R:R:C236	R:R:S193	5.16	No	No	0	5	6
144	R:R:K197	R:R:M233	5.76	No	No	0	6	6
145	R:R:K197	W:W:?1	16.71	No	Yes	0	6	0
146	R:R:L201	R:R:Y205	7.03	No	No	0	7	3
147	R:R:L201	W:W:?1	10.15	No	Yes	0	7	0
148	R:R:L217	R:R:M204	4.24	No	No	0	4	3
149	R:R:M204	R:R:Y220	9.58	No	Yes	0	3	3
150	R:R:Q210	R:R:Q211	3.84	No	No	0	4	4
151	R:R:Q211	R:R:Q213	7.68	No	No	0	4	4
152	R:R:H212	R:R:W214	16.93	No	Yes	1	3	1
153	R:R:Q221	R:R:Y220	5.64	No	Yes	0	4	3
154	R:R:C226	R:R:Y220	9.41	No	Yes	0	9	3
155	R:R:Y220	W:W:?1	5.29	Yes	Yes	0	3	0
156	R:R:C226	R:R:C296	7.28	No	No	0	9	9
157	R:R:D293	R:R:R227	13.1	No	No	0	7	8
158	R:R:C296	R:R:R227	4.18	No	No	0	9	8
159	R:R:R227	R:R:W297	29.99	No	Yes	0	8	8
160	R:R:V229	W:W:?1	4.2	No	Yes	0	7	0
161	R:R:F230	R:R:Q234	12.88	Yes	No	0	5	7
162	R:R:F230	R:R:W284	6.01	Yes	Yes	0	5	8
163	R:R:F230	R:R:T298	7.78	Yes	No	0	5	5
164	R:R:F230	W:W:?1	6.87	Yes	Yes	0	5	0
165	R:R:L231	R:R:V281	4.47	No	No	0	5	6
166	R:R:W274	R:R:Y235	6.75	Yes	No	0	9	9
167	R:R:L278	R:R:Y235	7.03	No	No	0	3	9
168	R:R:A238	R:R:F280	4.16	No	Yes	0	6	5
169	R:R:I313	R:R:Y241	12.09	No	No	0	7	8
170	R:R:E364	R:R:Y241	12.35	Yes	No	0	8	8
171	R:R:V276	R:R:Y242	5.05	No	No	0	3	6
172	R:R:P277	R:R:Y242	9.74	No	No	0	9	6
173	R:R:F280	R:R:Y242	10.32	Yes	No	0	5	6
174	R:R:V246	R:R:W243	7.36	No	Yes	0	8	9
175	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
176	R:R:W243	R:R:W274	24.37	Yes	Yes	5	9	9
177	R:R:L244	R:R:Q394	5.32	No	Yes	0	9	9
178	R:R:E247	R:R:L359	13.25	Yes	No	0	9	9
179	R:R:V249	R:R:Y269	7.57	No	Yes	0	6	7
180	R:R:L254	R:R:Y250	11.72	No	Yes	0	8	8
181	R:R:Y250	R:R:Y269	5.96	Yes	Yes	0	8	7
182	R:R:L251	R:R:V327	4.47	No	No	0	9	9
183	R:R:A256	R:R:Y252	8.01	No	No	0	6	8
184	R:R:R326	R:R:Y252	5.14	No	No	0	8	8
185	R:R:F257	R:R:T253	6.49	No	No	0	5	7
186	R:R:T253	R:R:Y269	6.24	No	Yes	0	7	7
187	R:R:L255	R:R:V327	4.47	No	No	0	8	9
188	R:R:I330	R:R:L255	4.28	No	No	0	9	8
189	R:R:Q263	R:R:R267	14.02	No	No	0	5	4
190	R:R:I265	R:R:W264	4.7	No	No	0	5	5
191	R:R:I265	R:R:Y269	8.46	No	Yes	0	5	7
192	R:R:F266	R:R:V270	6.55	Yes	No	0	6	5
193	R:R:F280	R:R:I309	3.77	Yes	No	0	5	7
194	R:R:F280	R:R:P312	21.67	Yes	No	0	5	8
195	R:R:G285	R:R:W284	4.22	No	Yes	0	5	8
196	R:R:I308	R:R:W284	8.22	No	Yes	0	8	8
197	R:R:I309	R:R:W284	14.09	No	Yes	0	7	8
198	R:R:V287	R:R:Y305	6.31	No	Yes	0	4	4
199	R:R:E292	R:R:K288	8.1	Yes	No	0	6	8
200	R:R:K288	R:R:W297	9.28	No	Yes	0	8	8
201	R:R:W297	R:R:Y289	6.75	Yes	No	0	8	3
202	R:R:L290	R:R:Y291	4.69	No	No	0	3	3
203	R:R:Y291	R:R:Y305	8.94	No	Yes	0	3	4
204	R:R:E292	R:R:S301	5.75	Yes	No	0	6	3
205	R:R:E292	R:R:N302	3.94	Yes	No	6	6	5
206	R:R:E292	R:R:Y305	6.73	Yes	Yes	6	6	4
207	R:R:E294	R:R:G295	4.91	No	No	0	4	4
208	R:R:E294	R:R:R299	15.12	No	No	0	4	4
209	R:R:N300	R:R:W306	6.78	No	Yes	0	6	6
210	R:R:N302	R:R:Y305	9.3	No	Yes	6	5	4
211	R:R:M303	R:R:W306	5.82	No	Yes	0	5	6
212	R:R:L307	R:R:N304	4.12	No	No	0	7	3
213	R:R:I309	R:R:W306	4.7	No	Yes	0	7	6
214	R:R:R310	R:R:W306	4	No	Yes	0	6	6
215	R:R:L307	R:R:L311	9.69	No	No	0	7	4
216	R:R:L314	R:R:R310	7.29	No	No	0	4	6
217	R:R:F315	R:R:V319	7.87	No	No	0	4	6
218	R:R:E364	R:R:I317	6.83	Yes	No	0	8	7
219	R:R:L360	R:R:N320	10.98	Yes	No	0	9	9
220	R:R:F321	R:R:V325	6.55	No	No	0	6	5
221	R:R:F321	R:R:T362	5.19	No	No	0	6	7
222	R:R:F321	R:R:V365	9.18	No	No	0	6	6
223	R:R:F324	R:R:I328	6.28	Yes	No	0	9	7
224	R:R:F324	R:R:L356	7.31	Yes	No	0	9	9
225	R:R:F324	R:R:I357	3.77	Yes	No	0	9	8
226	R:R:F324	R:R:T362	14.27	Yes	No	0	9	7
227	R:R:I328	R:R:T353	4.56	No	No	0	7	9
228	R:R:S352	R:R:V331	6.46	No	No	0	9	8
229	R:R:L349	R:R:V332	4.47	No	No	0	9	6
230	R:R:I345	R:R:L335	5.71	No	No	0	5	8
231	R:R:L335	R:R:R348	4.86	No	No	0	8	8
232	R:R:D344	R:R:I345	7	No	No	0	7	5
233	R:R:K351	R:R:R348	6.19	No	No	0	8	8
234	R:R:K351	R:R:T355	4.5	No	No	0	8	8
235	R:R:L401	R:R:T355	5.9	No	No	0	8	8
236	R:R:L359	R:R:L360	4.15	No	Yes	0	9	9
237	R:R:L359	R:R:Y402	19.93	No	No	0	9	8
238	R:R:L360	R:R:T362	4.42	Yes	No	0	9	7
239	R:R:E364	R:R:H363	11.08	Yes	No	0	8	8
240	R:R:F390	R:R:H363	5.66	No	No	0	6	8
241	R:R:H363	R:R:Q394	8.65	No	Yes	0	8	9
242	R:R:E364	R:R:F367	8.16	Yes	No	0	8	7
243	R:R:E387	R:R:F367	16.32	No	No	0	8	7
244	R:R:F369	R:R:M371	4.98	No	No	0	4	7
245	R:R:H374	R:R:M371	6.57	Yes	No	0	3	7
246	R:R:H374	R:R:L379	9	Yes	No	0	3	3
247	R:R:H374	R:R:K383	13.1	Yes	No	0	3	7
248	R:R:F381	R:R:T378	5.19	No	No	0	4	2
249	R:R:F381	R:R:R380	6.41	No	No	0	4	5
250	R:R:F385	R:R:I382	6.28	Yes	No	0	6	4
251	R:R:E387	R:R:L384	5.3	No	No	0	8	5
252	R:R:E387	R:R:L388	6.63	No	No	0	8	7
253	R:R:F393	R:R:S392	5.28	No	No	0	7	9
254	R:R:I400	R:R:M397	4.37	Yes	No	0	6	5
255	R:R:V398	R:R:Y402	3.79	No	No	0	9	8
256	R:R:I400	R:R:L401	5.71	Yes	No	0	6	8
257	R:R:F404	R:R:I400	3.77	No	Yes	0	8	6
258	R:R:C403	R:R:F404	4.19	No	No	0	9	8
259	R:R:N406	R:R:N407	4.09	No	No	0	9	6
260	R:R:N406	R:R:V409	4.43	No	No	0	9	9
261	R:R:E412	R:R:K415	10.8	Yes	No	0	8	7
262	R:R:K415	R:R:R419	17.33	No	No	0	7	7
263	R:R:W417	R:R:W420	5.62	No	No	0	5	4
264	R:R:R421	R:R:W417	8	No	No	0	4	5
265	R:R:E418	R:R:R421	9.3	No	No	0	4	4
266	R:R:P137	W:W:?1	3.71	No	Yes	0	3	0
267	R:R:G151	R:R:S392	3.71	No	No	0	8	9
268	R:R:G216	R:R:S219	3.71	No	No	0	2	5
269	R:R:F385	R:R:L144	3.65	Yes	No	0	6	6
270	R:R:I323	R:R:Y252	3.63	No	No	0	8	8
271	R:R:A162	R:R:C403	3.61	No	No	0	9	9
272	R:R:P137	R:R:S31	3.56	No	No	0	3	4
273	R:R:G248	R:R:I323	3.53	No	No	0	8	8
274	R:R:P283	R:R:V282	3.53	No	No	0	5	3
275	R:R:E262	R:R:F260	3.5	No	No	0	6	7
276	R:R:C46	R:R:S49	3.44	No	No	0	8	2
277	R:R:C85	R:R:V95	3.42	No	Yes	0	9	5
278	R:R:L231	R:R:W297	3.42	No	Yes	0	5	8
279	R:R:L268	R:R:W264	3.42	No	No	0	2	5
280	R:R:I357	R:R:P358	3.39	No	No	0	8	9
281	R:R:G295	R:R:Q37	3.29	No	No	0	4	4
282	R:R:G361	R:R:Q394	3.29	No	Yes	0	9	9
283	R:R:K202	W:W:?1	3.18	No	Yes	0	4	0
284	R:R:C236	R:R:L189	3.17	No	No	0	5	7
285	R:R:A208	R:R:L217	3.15	No	No	0	4	4
286	R:R:A316	R:R:L245	3.15	No	No	0	7	8
287	R:R:I147	R:R:S389	3.1	Yes	No	0	6	5
288	R:R:I328	R:R:S352	3.1	No	No	0	7	9
289	R:R:I272	R:R:V246	3.07	No	No	0	6	8
290	R:R:K202	R:R:S206	3.06	No	No	0	4	4
291	R:R:A209	R:R:Q210	3.03	No	No	0	1	4
292	R:R:L181	R:R:S163	3	No	No	0	6	6
293	R:R:L123	R:R:V100	2.98	No	No	0	5	7
294	R:R:L245	R:R:V249	2.98	No	No	0	8	6
295	R:R:L245	R:R:V319	2.98	No	No	0	8	6
296	R:R:L278	R:R:V282	2.98	No	No	0	3	3
297	R:R:L356	R:R:V327	2.98	No	No	0	9	9
298	R:R:I146	R:R:I147	2.94	No	Yes	0	4	6
299	R:R:I196	R:R:M233	2.92	No	No	0	5	6
300	R:R:D372	R:R:V370	2.92	No	No	0	5	5
301	R:R:D198	R:R:T149	2.89	No	No	0	7	7
302	R:R:E125	R:R:V100	2.85	No	No	0	5	7
303	R:R:I400	R:R:L396	2.85	Yes	No	0	6	7
304	R:R:E107	R:R:T105	2.82	No	No	0	5	4
305	R:R:E262	R:R:T175	2.82	No	No	0	6	7
306	R:R:L154	R:R:L396	2.77	No	No	0	5	7
307	R:R:L166	R:R:L181	2.77	Yes	No	0	8	6
308	R:R:A375	R:R:R380	2.77	No	No	0	4	5
309	R:R:N302	R:R:N304	2.72	No	No	0	5	3
310	R:R:K113	R:R:Q112	2.71	No	Yes	0	4	3
311	R:R:D74	R:R:N63	2.69	Yes	No	0	3	4
312	R:R:E408	R:R:L172	2.65	No	Yes	0	9	9
313	R:R:F393	R:R:S389	2.64	No	No	0	7	5
314	R:R:F103	R:R:T105	2.59	Yes	No	0	4	4
315	R:R:F195	R:R:T149	2.59	No	No	0	7	7
316	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
317	R:R:F385	R:R:T386	2.59	Yes	No	0	6	4
318	R:R:S155	R:R:Y152	2.54	No	No	0	9	7
319	R:R:S223	R:R:Y220	2.54	No	Yes	0	4	3
320	R:R:F367	R:R:I366	2.51	No	No	0	7	6
321	R:R:S261	R:R:W264	2.47	No	No	0	7	5
322	R:R:D222	R:R:R40	2.38	No	No	0	6	2
323	R:R:L224	R:R:Y289	2.34	No	No	0	3	3
324	R:R:E41	R:R:W87	2.18	No	No	0	4	3
325	R:R:G275	R:R:P277	2.03	No	No	0	6	9
326	R:R:C104	R:R:G108	1.96	No	No	0	9	9
327	R:R:P54	R:R:P55	1.95	No	No	0	2	1
328	R:R:P55	R:R:P56	1.95	No	Yes	0	1	1
329	R:R:A106	R:R:P77	1.87	No	No	0	1	4
330	R:R:G98	R:R:V95	1.84	No	Yes	0	4	5
331	R:R:G151	R:R:V150	1.84	No	No	0	8	5
332	R:R:A158	R:R:A399	1.79	No	No	0	7	8
333	R:R:A162	R:R:A399	1.79	No	No	0	9	8
334	R:R:A200	W:W:?1	1.78	No	Yes	0	4	0
335	R:R:P90	R:R:V30	1.77	No	No	0	4	2
336	R:R:P96	R:R:V95	1.77	No	Yes	0	3	5
337	R:R:G318	R:R:I317	1.76	No	No	0	4	7
338	R:R:P137	R:R:T29	1.75	No	No	0	3	2
339	R:R:A28	R:R:S135	1.71	No	No	0	2	1
340	R:R:A158	R:R:S157	1.71	No	No	0	7	3
341	R:R:G168	R:R:L167	1.71	No	No	0	1	3
342	R:R:G248	R:R:L360	1.71	No	Yes	0	8	9
343	R:R:D74	R:R:G75	1.68	Yes	No	0	3	7
344	R:R:D215	R:R:G216	1.68	No	No	0	3	2
345	R:R:L118	R:R:P119	1.64	No	No	0	4	6
346	R:R:S223	R:R:S225	1.63	No	No	0	4	3
347	R:R:A368	R:R:I317	1.62	No	No	0	6	7
348	R:R:A92	R:R:L89	1.58	No	No	0	5	5
349	R:R:A185	R:R:N182	1.56	No	No	0	3	9
350	R:R:I161	R:R:V160	1.54	No	No	0	4	3
351	R:R:I188	R:R:V160	1.54	No	No	0	7	3
352	R:R:A199	R:R:D198	1.54	No	No	0	3	7
353	R:R:K334	R:R:S333	1.53	No	No	0	9	7
354	R:R:K336	R:R:V332	1.52	No	No	0	6	6
355	R:R:L401	R:R:V405	1.49	No	No	0	8	6
356	R:R:L349	R:R:T353	1.47	No	No	0	9	9
357	R:R:L354	R:R:T353	1.47	No	No	0	8	9
358	R:R:I330	R:R:K334	1.45	No	No	0	9	9
359	R:R:Q263	R:R:S261	1.44	No	No	0	5	7
360	R:R:I146	R:R:L142	1.43	No	No	0	4	3
361	R:R:I382	R:R:L379	1.43	No	No	0	4	3
362	R:R:Q47	R:R:T51	1.42	No	No	0	3	4
363	R:R:C62	R:R:R102	1.39	No	No	0	9	8
364	R:R:A153	R:R:F195	1.39	No	No	0	6	7
365	R:R:D114	R:R:K113	1.38	No	No	0	4	4
366	R:R:L224	R:R:L228	1.38	No	No	0	3	4
367	R:R:D114	R:R:N115	1.35	No	No	0	4	4
368	R:R:E373	R:R:M371	1.35	No	No	0	4	7
369	R:R:L141	R:R:Q140	1.33	No	No	0	5	4
370	R:R:N82	R:R:Y101	1.16	No	No	0	4	5
371	R:R:M204	R:R:W203	1.16	No	No	0	3	3
372	R:R:H374	R:R:R380	1.13	Yes	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	10.3725	4	1	5
2	R:R:Y42	6.46	5	1	6
3	R:R:R43	7.2925	4	1	4
4	R:R:P56	8.985	4	0	1
5	R:R:R64	12.8925	4	2	4
6	R:R:F66	6.91	5	1	7
7	R:R:Y69	8.1625	4	1	6
8	R:R:W72	11.865	4	1	9
9	R:R:D74	6.644	5	2	3
10	R:R:Y88	6.68143	7	1	5
11	R:R:V95	2.97	4	0	5
12	R:R:F103	16.775	4	0	4
13	R:R:Q112	5.1425	4	0	3
14	R:R:W120	11.8725	4	3	5
15	R:R:R121	9.4875	4	1	6
16	R:R:I147	4.3375	4	0	6
17	R:R:L166	4.6375	4	0	8
18	R:R:L172	4.185	4	0	9
19	R:R:R176	5.6125	4	4	9
20	R:R:F187	8.166	5	0	8
21	R:R:R190	10.03	4	0	8
22	R:R:W214	10.4625	4	1	1
23	R:R:Y220	6.492	5	0	3
24	R:R:F230	8.385	4	0	5
25	R:R:W243	13.132	5	5	9
26	R:R:E247	9.1075	4	0	9
27	R:R:Y250	6.576	5	0	8
28	R:R:F266	5.2225	4	0	6
29	R:R:Y269	7.0575	4	0	7
30	R:R:W274	9.5575	4	5	9
31	R:R:F280	9.98	4	0	5
32	R:R:W284	8.135	4	0	8
33	R:R:E292	6.13	4	6	6
34	R:R:W297	12.36	4	0	8
35	R:R:Y305	7.82	4	6	4
36	R:R:W306	5.325	4	0	6
37	R:R:F324	7.9075	4	0	9
38	R:R:L360	5.315	4	0	9
39	R:R:E364	9.605	4	0	8
40	R:R:H374	7.45	4	0	3
41	R:R:F385	5.015	4	0	6
42	R:R:Q394	6.6575	4	0	9
43	R:R:I400	4.175	4	0	6
44	R:R:E412	9.12	4	0	8
45	W:W:?1	8.065	12	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y220	W:W:?1	99.4663	5.29	Yes	Yes	0	3	0
2	R:R:M204	R:R:Y220	95.5139	9.58	No	Yes	0	3	3
3	R:R:L217	R:R:M204	95.116	4.24	No	No	0	4	3
4	R:R:L217	R:R:V36	94.7053	4.47	No	No	0	4	2
5	R:R:V36	R:R:W214	94.495	9.81	No	Yes	0	2	1
6	R:R:W214	R:R:Y88	49.7049	3.86	Yes	Yes	1	1	5
7	R:R:Y42	R:R:Y88	29.4138	6.95	Yes	Yes	1	6	5
8	R:R:W214	R:R:W39	26.1454	11.25	Yes	Yes	1	1	5
9	R:R:R43	R:R:W39	14.2783	5	Yes	Yes	1	4	5
10	R:R:E68	R:R:W39	11.8962	9.81	No	Yes	1	4	5
11	R:R:F66	R:R:R43	11.5452	6.41	Yes	Yes	1	7	4
12	R:R:E68	R:R:F66	11.356	12.83	No	Yes	1	4	7
13	R:R:F66	R:R:Y42	13.2433	4.13	Yes	Yes	1	7	6
14	R:R:C71	R:R:Y42	13.1819	8.06	No	Yes	1	9	6
15	R:R:C46	R:R:F66	34.4174	5.59	No	Yes	1	8	7
16	R:R:C46	R:R:C71	12.6255	7.28	No	No	1	8	9
17	R:R:C46	R:R:S49	44.8435	3.44	No	No	0	8	2
18	R:R:L50	R:R:S49	42.6312	4.5	No	No	0	4	2
19	R:R:L50	R:R:R64	40.4156	14.58	No	Yes	0	4	4
20	R:R:D74	R:R:R64	29.2844	7.15	Yes	Yes	2	3	4
21	R:R:D74	R:R:P56	22.5908	17.71	Yes	Yes	0	3	1
22	R:R:R121	R:R:Y69	19.8156	9.26	Yes	Yes	1	6	6
23	R:R:Y69	R:R:Y88	21.8032	3.97	Yes	Yes	1	6	5
24	R:R:H212	R:R:Y69	17.9785	6.53	No	Yes	1	3	6
25	R:R:H212	R:R:W214	18.4507	16.93	No	Yes	1	3	1
26	R:R:L123	R:R:Y69	19.827	12.89	No	Yes	0	5	6
27	R:R:L123	R:R:V100	18.7062	2.98	No	No	0	5	7
28	R:R:E125	R:R:V100	17.5613	2.85	No	No	0	5	7
29	R:R:E125	R:R:Y101	16.413	8.98	No	No	0	5	5
30	R:R:W120	R:R:Y101	11.7878	6.75	Yes	No	0	5	5
31	R:R:L141	W:W:?1	20.8701	9.37	No	Yes	0	5	0
32	R:R:L141	R:R:L144	17.9267	5.54	No	No	0	5	6
33	R:R:F385	R:R:L144	17.1828	3.65	Yes	No	0	6	6
34	R:R:Y145	W:W:?1	100	14.55	No	Yes	0	5	0
35	R:R:Y145	R:R:Y148	99.0976	4.96	No	No	0	5	7
36	R:R:L388	R:R:Y148	98.2567	9.38	No	No	0	7	7
37	R:R:E387	R:R:L388	98.0788	6.63	No	No	0	8	7
38	R:R:E387	R:R:F367	97.7133	16.32	No	No	0	8	7
39	R:R:E364	R:R:F367	97.3348	8.16	Yes	No	0	8	7
40	R:R:E364	R:R:H363	86.8553	11.08	Yes	No	0	8	8
41	R:R:H363	R:R:Q394	86.4058	8.65	No	Yes	0	8	9
42	R:R:F187	R:R:Q394	85.733	9.37	Yes	Yes	0	8	9
43	R:R:F187	R:R:V398	42.6263	3.93	Yes	No	0	8	9
44	R:R:F184	R:R:V398	11.1539	3.93	No	No	0	8	9
45	R:R:F184	R:R:L159	10.486	7.31	No	No	0	8	9
46	R:R:F187	R:R:L183	47.6332	6.09	Yes	No	0	8	9
47	R:R:E247	R:R:L183	47.2273	6.63	Yes	No	0	9	9
48	R:R:E247	R:R:H180	16.489	11.08	Yes	No	0	9	9
49	R:R:H180	R:R:R176	31.8881	4.51	No	Yes	0	9	9
50	R:R:N177	R:R:R176	31.1426	9.64	No	Yes	4	9	9
51	R:R:L166	R:R:N177	30.004	6.87	Yes	No	0	8	9
52	R:R:L166	R:R:L172	15.737	4.15	Yes	Yes	0	8	9
53	R:R:V398	R:R:Y402	32.26	3.79	No	No	0	9	8
54	R:R:H180	R:R:Y402	16.6928	8.71	No	No	0	9	8
55	R:R:E247	R:R:I179	17.1375	5.47	Yes	No	0	9	8
56	R:R:I179	R:R:Y250	12.0385	4.84	No	Yes	0	8	8
57	R:R:N240	R:R:S186	10.342	5.96	No	No	0	9	9
58	R:R:C226	R:R:Y220	16.2998	9.41	No	Yes	0	9	3
59	R:R:C226	R:R:C296	15.5559	7.28	No	No	0	9	9
60	R:R:C296	R:R:R227	14.8088	4.18	No	No	0	9	8
61	R:R:R227	R:R:W297	13.3048	29.99	No	Yes	0	8	8
62	R:R:F230	W:W:?1	14.9317	6.87	Yes	Yes	0	5	0
63	R:R:F230	R:R:W284	12.6514	6.01	Yes	Yes	0	5	8
64	R:R:I309	R:R:W284	10.342	14.09	No	Yes	0	7	8
65	R:R:E247	R:R:L359	20.0178	13.25	Yes	No	0	9	9
66	R:R:L359	R:R:Y402	18.9504	19.93	No	No	0	9	8
67	R:R:L359	R:R:L360	37.5645	4.15	No	Yes	0	9	9
68	R:R:L360	R:R:T362	28.7459	4.42	Yes	No	0	9	7
69	R:R:F324	R:R:T362	23.6355	14.27	Yes	No	0	9	7
70	R:R:F324	R:R:I328	10.6331	6.28	Yes	No	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q221	R:R:W33	16.43	No	No	4	3	2	1
R:R:W33	W:W:?1	13.49	No	Yes	3	0	1	0
R:R:E138	R:R:E139	19.03	No	No	2	2	1	2
R:R:E138	W:W:?1	7.48	No	Yes	2	0	1	0
R:R:L141	R:R:L144	5.54	No	No	5	6	1	2
R:R:L141	W:W:?1	9.37	No	Yes	5	0	1	0
R:R:Y145	R:R:Y148	4.96	No	No	5	7	1	2
R:R:D198	R:R:Y145	12.64	No	No	7	5	2	1
R:R:Y145	W:W:?1	14.55	No	Yes	5	0	1	0
R:R:K197	R:R:M233	5.76	No	No	6	6	1	2
R:R:K197	W:W:?1	16.71	No	Yes	6	0	1	0
R:R:L201	R:R:Y205	7.03	No	No	7	3	1	2
R:R:L201	W:W:?1	10.15	No	Yes	7	0	1	0
R:R:M204	R:R:Y220	9.58	No	Yes	3	3	2	1
R:R:Q221	R:R:Y220	5.64	No	Yes	4	3	2	1
R:R:C226	R:R:Y220	9.41	No	Yes	9	3	2	1
R:R:Y220	W:W:?1	5.29	Yes	Yes	3	0	1	0
R:R:V229	W:W:?1	4.2	No	Yes	7	0	1	0
R:R:F230	R:R:Q234	12.88	Yes	No	5	7	1	2
R:R:F230	R:R:W284	6.01	Yes	Yes	5	8	1	2
R:R:F230	R:R:T298	7.78	Yes	No	5	5	1	2
R:R:F230	W:W:?1	6.87	Yes	Yes	5	0	1	0
R:R:P137	W:W:?1	3.71	No	Yes	3	0	1	0
R:R:P137	R:R:S31	3.56	No	No	3	4	1	2
R:R:K202	W:W:?1	3.18	No	Yes	4	0	1	0
R:R:K202	R:R:S206	3.06	No	No	4	4	1	2
R:R:S223	R:R:Y220	2.54	No	Yes	4	3	2	1
R:R:A200	W:W:?1	1.78	No	Yes	4	0	1	0
R:R:P137	R:R:T29	1.75	No	No	3	2	1	2
R:R:L141	R:R:Q140	1.33	No	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6XOX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	355
Number of Links	372
Number of Hubs	45
Number of Links mediated by Hubs	175
Number of Communities	6
Number of Nodes involved in Communities	30
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	107548
Length Of Smallest Path	3
Average Path Length	20.1311
Length of Longest Path	42
Minimum Path Strength	1.365
Average Path Strength	7.73224
Maximum Path Strength	31.2667
Minimum Path Correlation	0.71
Average Path Correlation	0.956554
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	51.1309
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.5402
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • cognition • transport • secretion • regulation of hormone levels • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • cellular macromolecule localization • establishment of localization in cell • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein localization to membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	V6G
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	V6G
Name	Orforglipron
Synonyms	3-[(1S,2S)-1-({2-(4-fluoro-3,5-dimethylphenyl)-3-({3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}carbonyl)-5-[(4S)-2,2-dimethyloxan-4-yl]-1H-indol-1-yl}-2-methylcyc Orforglipron 1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dim
Identifier
Formula	C48 H48 F2 N10 O5
Molecular Weight	882.956
SMILES
PubChem	137319706
Formal Charge	0
Total Atoms	113
Total Chiral Atoms	4
Total Bonds	123
Total Aromatic Bonds	31


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>6XOX_nogp_Chain_R A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6XOX_nogp.zip

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