psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S31	R:R:W33	3.71	No	No	0	4	3
2	R:R:E34	R:R:S31	4.31	No	No	0	4	4
3	L:L:D15	R:R:S31	4.42	No	No	0	0	4
4	R:R:L218	R:R:W33	3.42	No	No	0	3	3
5	R:R:E34	R:R:K38	12.15	No	No	0	4	4
6	R:R:T35	R:R:Y88	3.75	No	Yes	0	5	5
7	R:R:L218	R:R:V36	7.45	No	No	0	3	2
8	L:L:F22	R:R:V36	5.24	Yes	No	0	0	2
9	R:R:Q37	R:R:R40	4.67	No	No	0	4	2
10	R:R:R43	R:R:W39	15.99	No	Yes	0	4	5
11	R:R:W39	R:R:Y88	12.54	Yes	Yes	1	5	5
12	L:L:F22	R:R:W39	10.02	Yes	Yes	1	0	5
13	L:L:L26	R:R:W39	15.94	Yes	Yes	1	0	5
14	R:R:R40	R:R:R44	7.46	No	No	0	2	3
15	R:R:E41	R:R:Q45	3.82	No	Yes	1	4	5
16	R:R:E41	R:R:W87	4.36	No	No	1	4	3
17	R:R:Q45	R:R:Y42	10.15	Yes	Yes	1	5	6
18	R:R:P86	R:R:Y42	8.34	Yes	Yes	1	8	6
19	R:R:W87	R:R:Y42	13.5	No	Yes	1	3	6
20	R:R:Y42	R:R:Y88	14.89	Yes	Yes	1	6	5
21	R:R:C46	R:R:R43	4.18	No	No	0	8	4
22	R:R:Q47	R:R:R44	7.01	No	No	0	3	3
23	R:R:Q45	R:R:R48	9.35	Yes	No	0	5	4
24	R:R:Q45	R:R:W87	13.14	Yes	No	1	5	3
25	R:R:C46	R:R:C71	7.28	No	No	0	8	9
26	R:R:L50	R:R:Q47	5.32	No	No	0	4	3
27	R:R:C71	R:R:S49	3.44	No	No	0	9	2
28	R:R:S49	R:R:W72	4.94	No	No	0	2	9
29	R:R:E52	R:R:W72	5.45	No	No	0	2	9
30	R:R:D53	R:R:F66	7.17	No	Yes	10	3	7
31	R:R:D53	R:R:P73	9.66	No	No	10	3	5
32	R:R:P54	R:R:W72	20.27	No	No	0	2	9
33	R:R:P54	R:R:P73	3.9	No	No	0	2	5
34	R:R:A57	R:R:E76	6.03	No	No	0	1	1
35	R:R:D59	R:R:P77	4.83	No	Yes	0	3	4
36	R:R:A106	R:R:D59	4.63	No	No	0	1	3
37	R:R:G108	R:R:L60	3.42	No	No	0	9	1
38	R:R:F61	R:R:N63	10.87	No	No	11	3	4
39	R:R:D74	R:R:F61	15.52	No	No	11	3	3
40	R:R:C62	R:R:P77	3.77	No	Yes	2	9	4
41	R:R:C104	R:R:C62	7.28	No	No	2	9	9
42	R:R:N63	R:R:T65	8.77	No	No	0	4	5
43	R:R:D74	R:R:N63	5.39	No	No	11	3	4
44	R:R:R64	R:R:Y69	20.58	Yes	Yes	0	4	6
45	R:R:R64	R:R:V83	10.46	Yes	No	0	4	5
46	R:R:R102	R:R:R64	5.33	Yes	Yes	2	8	4
47	R:R:R64	R:R:W110	7	Yes	Yes	2	4	9
48	R:R:F66	R:R:T65	3.89	Yes	No	0	7	5
49	R:R:C71	R:R:F66	9.78	No	Yes	0	9	7
50	R:R:F66	R:R:P73	7.22	Yes	No	10	7	5
51	R:R:D67	R:R:Y69	16.09	No	Yes	0	9	6
52	R:R:A70	R:R:Y69	5.34	No	Yes	0	5	6
53	L:L:E27	R:R:Y69	3.37	Yes	Yes	0	0	6
54	R:R:E76	R:R:P77	7.86	No	Yes	0	1	4
55	R:R:C104	R:R:P77	3.77	No	Yes	2	9	4
56	R:R:F80	R:R:N82	8.46	No	No	4	4	4
57	R:R:F80	R:R:Y101	7.22	No	Yes	4	4	5
58	R:R:F103	R:R:F80	13.93	No	No	0	4	4
59	R:R:V81	R:R:W110	3.68	No	Yes	0	6	9
60	R:R:H99	R:R:N82	8.93	No	No	4	4	4
61	R:R:N82	R:R:Y101	6.98	No	Yes	4	4	5
62	R:R:C85	R:R:P86	3.77	No	Yes	0	9	8
63	R:R:C126	R:R:C85	5.46	No	No	0	9	9
64	R:R:P86	R:R:Y88	4.17	Yes	Yes	1	8	5
65	R:R:L89	R:R:P86	6.57	Yes	Yes	1	5	8
66	L:L:E27	R:R:P86	4.72	Yes	Yes	1	0	8
67	L:L:V23	R:R:Y88	3.79	Yes	Yes	1	0	5
68	L:L:L26	R:R:Y88	5.86	Yes	Yes	1	0	5
69	L:L:E27	R:R:Y88	10.1	Yes	Yes	1	0	5
70	R:R:A92	R:R:L89	6.3	No	Yes	0	5	5
71	R:R:E127	R:R:L89	10.6	No	Yes	1	2	5
72	L:L:V23	R:R:L89	7.45	Yes	Yes	1	0	5
73	L:L:E27	R:R:L89	3.98	Yes	Yes	1	0	5
74	R:R:E128	R:R:W91	5.45	No	No	0	3	4
75	L:L:Q20	R:R:W91	18.62	No	No	0	0	4
76	R:R:P96	R:R:Q97	4.74	No	No	0	3	4
77	R:R:E125	R:R:G98	3.27	Yes	No	0	5	4
78	R:R:H99	R:R:Y101	20.69	No	Yes	4	4	5
79	R:R:D122	R:R:Y101	9.2	No	Yes	4	7	5
80	R:R:E125	R:R:Y101	5.61	Yes	Yes	4	5	5
81	R:R:R102	R:R:W110	21.99	Yes	Yes	2	8	9
82	R:R:F103	R:R:L111	3.65	No	No	0	4	4
83	R:R:C104	R:R:W110	6.53	No	Yes	2	9	9
84	R:R:E107	R:R:T105	5.64	No	No	0	5	4
85	R:R:E107	R:R:L109	6.63	No	No	0	5	5
86	R:R:L109	R:R:Q112	15.97	No	No	0	5	3
87	R:R:Q112	R:R:W110	3.29	No	Yes	2	3	9
88	R:R:P119	R:R:W110	6.76	No	Yes	2	6	9
89	R:R:L111	R:R:W120	11.39	No	No	0	4	5
90	R:R:P119	R:R:Q112	11.05	No	No	2	6	3
91	R:R:D114	R:R:K113	4.15	No	No	0	4	4
92	R:R:D114	R:R:S117	8.83	No	No	0	4	7
93	R:R:L118	R:R:R121	6.07	No	No	0	4	6
94	R:R:R121	R:R:W120	5	No	No	0	6	5
95	R:R:D122	R:R:S124	5.89	No	No	4	7	5
96	R:R:D122	R:R:E125	10.39	No	Yes	4	7	5
97	R:R:E125	R:R:S124	4.31	Yes	No	4	5	5
98	L:L:V23	R:R:E127	5.7	Yes	No	1	0	2
99	R:R:E138	R:R:L141	6.63	No	No	0	2	5
100	L:L:Y13	R:R:E138	16.83	No	No	0	0	2
101	R:R:F381	R:R:Q140	8.2	No	No	0	4	4
102	L:L:F6	R:R:L141	3.65	No	No	0	0	5
103	R:R:I146	R:R:L142	4.28	No	No	0	4	3
104	L:L:F6	R:R:L144	3.65	No	No	0	0	6
105	R:R:D198	R:R:Y145	6.9	No	No	0	7	5
106	L:L:?1	R:R:Y145	23.3	Yes	No	0	0	5
107	L:L:?1	R:R:I146	4.05	Yes	No	0	0	4
108	R:R:Y148	R:R:Y152	4.96	Yes	Yes	0	7	7
109	R:R:D198	R:R:Y148	5.75	No	Yes	0	7	7
110	R:R:L388	R:R:Y148	4.69	No	Yes	0	7	7
111	L:L:F6	R:R:Y148	8.25	No	Yes	0	0	7
112	L:L:?1	R:R:T149	4.18	Yes	No	0	0	7
113	R:R:G151	R:R:S392	3.71	No	No	12	8	9
114	R:R:F393	R:R:G151	9.03	No	No	12	7	8
115	R:R:R190	R:R:Y152	9.26	Yes	Yes	0	8	7
116	R:R:V194	R:R:Y152	10.09	No	Yes	0	7	7
117	R:R:S392	R:R:Y152	7.63	No	Yes	0	9	7
118	L:L:Q3	R:R:Y152	4.51	No	Yes	0	0	7
119	L:L:?1	R:R:A153	4.47	Yes	No	0	0	6
120	L:L:?1	R:R:L154	10.48	Yes	No	0	0	5
121	R:R:G395	R:R:S155	3.71	No	No	0	9	9
122	R:R:F156	R:R:V160	7.87	Yes	No	14	7	3
123	R:R:F156	R:R:I188	8.79	Yes	No	14	7	7
124	R:R:F156	R:R:L192	3.65	Yes	No	0	7	3
125	L:L:?1	R:R:S157	4.26	Yes	No	0	0	3
126	R:R:F184	R:R:L159	4.87	No	Yes	0	8	9
127	R:R:F187	R:R:L159	3.65	Yes	Yes	13	8	9
128	R:R:G395	R:R:L159	3.42	No	Yes	13	9	9
129	R:R:I188	R:R:V160	4.61	No	No	14	7	3
130	R:R:F404	R:R:I161	3.77	No	No	0	8	4
131	R:R:A162	R:R:F184	4.16	No	No	0	9	8
132	R:R:A162	R:R:C403	3.61	No	Yes	0	9	9
133	R:R:C403	R:R:I165	3.27	Yes	No	0	9	8
134	R:R:F413	R:R:I165	5.02	No	No	0	5	8
135	R:R:L166	R:R:N177	6.87	No	Yes	0	8	9
136	R:R:L166	R:R:L181	6.92	No	No	0	8	6
137	R:R:L167	R:R:L181	5.54	No	No	0	3	6
138	R:R:F169	R:R:L172	4.87	No	No	15	7	9
139	R:R:E412	R:R:F169	16.32	Yes	No	15	8	7
140	R:R:F169	R:R:F413	7.5	No	No	0	7	5
141	R:R:E412	R:R:H171	8.62	Yes	No	0	8	7
142	R:R:E412	R:R:L172	9.28	Yes	No	15	8	9
143	R:R:H173	R:R:Y178	6.53	No	No	0	7	6
144	R:R:C174	R:R:R176	4.18	No	Yes	8	8	9
145	R:R:C174	R:R:N177	4.72	No	Yes	8	8	9
146	R:R:T175	R:R:Y250	6.24	No	No	0	7	8
147	R:R:E262	R:R:T175	8.47	No	No	0	6	7
148	R:R:N177	R:R:R176	6.03	Yes	Yes	8	9	9
149	R:R:H180	R:R:R176	4.51	Yes	Yes	8	9	9
150	R:R:E408	R:R:R176	5.82	No	Yes	0	9	9
151	R:R:H180	R:R:N177	3.83	Yes	Yes	8	9	9
152	R:R:F266	R:R:Y178	4.13	No	No	0	6	6
153	R:R:E247	R:R:I179	9.56	No	No	0	9	8
154	R:R:E247	R:R:H180	11.08	No	Yes	0	9	9
155	R:R:H180	R:R:Y402	4.36	Yes	No	0	9	8
156	R:R:N182	R:R:W243	16.95	No	Yes	9	9	9
157	R:R:N182	R:R:W274	5.65	No	Yes	9	9	9
158	R:R:F187	R:R:L183	3.65	Yes	No	0	8	9
159	R:R:L183	R:R:L244	4.15	No	No	0	9	9
160	R:R:N240	R:R:S186	7.45	No	No	0	9	9
161	R:R:S186	R:R:W243	4.94	No	Yes	0	9	9
162	R:R:F187	R:R:N240	18.12	Yes	No	0	8	9
163	R:R:F187	R:R:Q394	9.37	Yes	No	0	8	9
164	R:R:F187	R:R:G395	6.02	Yes	No	13	8	9
165	R:R:C236	R:R:L189	4.76	No	No	0	5	7
166	R:R:R190	R:R:V237	9.15	Yes	No	0	8	6
167	R:R:N240	R:R:R190	8.44	No	Yes	0	9	8
168	R:R:R190	R:R:T391	3.88	Yes	No	0	8	6
169	R:R:C236	R:R:S193	6.89	No	No	0	5	6
170	R:R:D198	R:R:K197	6.91	No	Yes	0	7	6
171	R:R:F230	R:R:K197	4.96	Yes	Yes	0	5	6
172	R:R:K197	R:R:M233	4.32	Yes	No	0	6	6
173	L:L:T7	R:R:K197	4.5	No	Yes	0	0	6
174	R:R:L201	R:R:Y205	3.52	No	Yes	0	7	3
175	R:R:K202	R:R:T207	16.52	No	No	0	4	3
176	L:L:?1	R:R:K202	20.02	Yes	No	0	0	4
177	R:R:W203	R:R:Y220	7.72	No	No	0	3	3
178	R:R:M204	R:R:Y205	5.99	No	Yes	16	3	3
179	R:R:M204	R:R:Q221	16.31	No	No	16	3	4
180	R:R:C296	R:R:M204	4.86	Yes	No	0	9	3
181	R:R:Q221	R:R:Y205	3.38	No	Yes	16	4	3
182	L:L:S11	R:R:Y205	5.09	No	Yes	0	0	3
183	L:L:L14	R:R:Y205	4.69	No	Yes	0	0	3
184	L:L:D15	R:R:Y205	5.75	No	Yes	0	0	3
185	L:L:R18	R:R:S206	11.86	No	No	0	0	4
186	R:R:Q210	R:R:Q211	5.12	No	No	0	4	4
187	R:R:H212	R:R:Q213	11.13	No	No	0	3	4
188	R:R:D215	R:R:Q213	3.92	No	No	0	3	4
189	L:L:F22	R:R:W214	10.02	Yes	No	1	0	1
190	L:L:W25	R:R:W214	32.8	No	No	1	0	1
191	R:R:D215	R:R:G216	3.35	No	No	0	3	2
192	R:R:C226	R:R:C296	7.28	No	Yes	0	9	9
193	R:R:R227	R:R:W297	15.99	No	Yes	0	8	8
194	R:R:C296	R:R:F230	4.19	Yes	Yes	0	9	5
195	R:R:F230	R:R:T298	11.67	Yes	No	0	5	5
196	R:R:L231	R:R:W284	4.56	No	Yes	0	5	8
197	R:R:L231	R:R:W297	7.97	No	Yes	0	5	8
198	R:R:Q234	R:R:W284	14.24	No	Yes	3	7	8
199	R:R:I309	R:R:Q234	6.86	No	No	3	7	7
200	L:L:H1	R:R:Q234	4.95	Yes	No	0	0	7
201	R:R:W274	R:R:Y235	4.82	Yes	No	0	9	9
202	R:R:L278	R:R:Y235	4.69	No	No	0	3	9
203	L:L:H1	R:R:V237	9.69	Yes	No	0	0	6
204	R:R:A238	R:R:P277	3.74	No	Yes	0	6	9
205	R:R:I313	R:R:Y241	13.3	No	No	0	7	8
206	R:R:I317	R:R:Y241	7.25	No	No	5	7	8
207	R:R:E364	R:R:Y241	12.35	Yes	No	5	8	8
208	R:R:V276	R:R:Y242	7.57	No	Yes	6	3	6
209	R:R:P277	R:R:Y242	8.34	Yes	Yes	6	9	6
210	R:R:F280	R:R:Y242	7.22	No	Yes	6	5	6
211	R:R:P312	R:R:Y242	4.17	No	Yes	6	8	6
212	R:R:A316	R:R:Y242	4	No	Yes	0	7	6
213	R:R:V246	R:R:W243	3.68	No	Yes	0	8	9
214	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
215	R:R:W243	R:R:W274	24.37	Yes	Yes	9	9	9
216	R:R:L245	R:R:N320	6.87	No	No	0	8	9
217	R:R:E247	R:R:L359	3.98	No	No	0	9	9
218	R:R:G248	R:R:I323	3.53	No	No	0	8	8
219	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
220	R:R:L254	R:R:Y250	8.21	No	No	0	8	8
221	R:R:Y250	R:R:Y269	6.95	No	Yes	0	8	7
222	R:R:A256	R:R:Y252	6.67	No	No	0	6	8
223	R:R:R326	R:R:Y252	4.12	No	No	0	8	8
224	R:R:F257	R:R:T253	3.89	No	No	0	5	7
225	R:R:A256	R:R:F257	6.93	No	No	0	6	5
226	R:R:L260	R:R:W264	4.56	No	No	0	7	5
227	R:R:S261	R:R:W264	7.41	No	No	0	7	5
228	R:R:E262	R:R:I265	9.56	No	No	0	6	5
229	R:R:Q263	R:R:R267	16.35	No	No	0	5	4
230	R:R:I265	R:R:W264	5.87	No	No	0	5	5
231	R:R:I265	R:R:Y269	4.84	No	Yes	0	5	7
232	R:R:L268	R:R:Y269	4.69	No	Yes	0	2	7
233	R:R:G273	R:R:I272	3.53	No	No	0	9	6
234	R:R:P277	R:R:V276	3.53	Yes	No	6	9	3
235	R:R:F280	R:R:P312	20.23	No	No	6	5	8
236	R:R:P283	R:R:V282	3.53	No	No	0	5	3
237	R:R:G285	R:R:W284	4.22	No	Yes	0	5	8
238	R:R:K288	R:R:W284	17.4	Yes	Yes	3	8	8
239	R:R:I309	R:R:W284	15.27	No	Yes	3	7	8
240	R:R:I286	R:R:L290	4.28	No	No	0	4	3
241	R:R:V287	R:R:Y305	8.83	No	Yes	0	4	4
242	R:R:E292	R:R:K288	10.8	Yes	Yes	3	6	8
243	R:R:E294	R:R:K288	5.4	No	Yes	3	4	8
244	R:R:K288	R:R:W297	17.4	Yes	Yes	0	8	8
245	R:R:D293	R:R:Y289	4.6	No	No	0	7	3
246	R:R:W297	R:R:Y289	6.75	Yes	No	0	8	3
247	R:R:L290	R:R:Y291	14.07	No	No	0	3	3
248	R:R:Y291	R:R:Y305	3.97	No	Yes	0	3	4
249	R:R:E292	R:R:E294	11.42	Yes	No	3	6	4
250	R:R:E292	R:R:N302	3.94	Yes	No	3	6	5
251	R:R:E292	R:R:Y305	11.22	Yes	Yes	3	6	4
252	R:R:E294	R:R:S301	8.62	No	No	0	4	3
253	L:L:S11	R:R:T298	4.8	No	No	0	0	5
254	L:L:S11	R:R:R299	5.27	No	No	0	0	4
255	R:R:N300	R:R:W306	27.12	No	Yes	0	6	6
256	R:R:N302	R:R:N304	4.09	No	No	0	5	3
257	R:R:N302	R:R:Y305	17.44	No	Yes	3	5	4
258	R:R:M303	R:R:R310	4.96	No	Yes	7	5	6
259	R:R:E373	R:R:M303	9.47	Yes	No	7	4	5
260	R:R:I309	R:R:W306	8.22	No	Yes	0	7	6
261	R:R:R310	R:R:W306	21.99	Yes	Yes	0	6	6
262	L:L:H1	R:R:W306	9.52	Yes	Yes	0	0	6
263	R:R:L307	R:R:R310	8.5	No	Yes	0	7	6
264	R:R:L307	R:R:L311	4.15	No	No	0	7	4
265	R:R:D372	R:R:R310	5.96	No	Yes	7	5	6
266	R:R:E373	R:R:R310	12.79	Yes	Yes	7	4	6
267	R:R:F369	R:R:L314	3.65	Yes	No	0	4	4
268	R:R:F315	R:R:V319	6.55	No	No	0	4	6
269	R:R:E364	R:R:I317	4.1	Yes	No	5	8	7
270	R:R:F369	R:R:I317	3.77	Yes	No	0	4	7
271	R:R:F321	R:R:V365	13.11	No	No	0	6	6
272	R:R:F324	R:R:L356	6.09	No	Yes	0	9	9
273	R:R:F324	R:R:T362	12.97	No	No	0	9	7
274	R:R:I345	R:R:L335	4.28	No	No	0	5	8
275	R:R:I345	R:R:K336	7.27	No	No	0	5	6
276	R:R:D344	R:R:K342	12.44	No	No	0	7	5
277	R:R:R348	R:R:S352	6.59	No	No	0	8	9
278	R:R:L356	R:R:L360	4.15	Yes	No	0	9	9
279	R:R:I357	R:R:P358	3.39	No	No	0	8	9
280	R:R:I357	R:R:T362	7.6	No	No	0	8	7
281	R:R:L359	R:R:L360	4.15	No	No	0	9	9
282	R:R:L359	R:R:Y402	21.1	No	No	0	9	8
283	R:R:E364	R:R:H363	8.62	Yes	Yes	5	8	8
284	R:R:F390	R:R:H363	4.53	No	Yes	0	6	8
285	R:R:H363	R:R:T391	4.11	Yes	No	5	8	6
286	R:R:H363	R:R:Q394	11.13	Yes	No	0	8	9
287	R:R:E364	R:R:T391	5.64	Yes	No	5	8	6
288	R:R:F369	R:R:V365	9.18	Yes	No	0	4	6
289	R:R:F367	R:R:I366	3.77	Yes	No	0	7	6
290	R:R:F367	R:R:M371	6.22	Yes	Yes	0	7	7
291	R:R:F367	R:R:T386	5.19	Yes	No	0	7	4
292	R:R:A368	R:R:E387	4.53	No	No	0	6	8
293	R:R:M371	R:R:V370	9.13	Yes	No	0	7	5
294	R:R:K383	R:R:M371	7.2	No	Yes	0	7	7
295	R:R:D372	R:R:E373	12.99	No	Yes	7	5	4
296	R:R:D372	R:R:H374	7.56	No	No	7	5	3
297	R:R:E373	R:R:H374	7.39	Yes	No	7	4	3
298	R:R:A375	R:R:L379	4.73	No	No	0	4	3
299	R:R:R376	R:R:R380	4.26	No	No	0	5	5
300	L:L:D9	R:R:R380	4.76	No	No	0	0	5
301	R:R:E387	R:R:K383	6.75	No	No	0	8	7
302	R:R:F385	R:R:S389	7.93	Yes	No	0	6	5
303	L:L:S2	R:R:E387	12.94	No	No	0	0	8
304	L:L:S2	R:R:L388	4.5	No	No	0	0	7
305	R:R:F393	R:R:S392	5.28	No	No	12	7	9
306	R:R:F404	R:R:I400	3.77	No	No	0	8	6
307	R:R:C403	R:R:F404	4.19	Yes	No	0	9	8
308	R:R:N406	R:R:V409	4.43	No	No	0	9	9
309	R:R:E412	R:R:K415	6.75	Yes	No	0	8	7
310	R:R:R421	R:R:W417	5	No	No	0	4	5
311	R:R:E423	R:R:W420	10.9	No	No	0	4	4
312	L:L:?1	L:L:K10	12.01	Yes	No	0	0	0
313	L:L:E17	L:L:Y13	10.1	No	No	0	0	0
314	L:L:E17	L:L:R18	5.82	No	No	0	0	0
315	L:L:E17	L:L:Q20	10.19	No	No	0	0	0
316	L:L:D21	L:L:R18	4.76	No	No	0	0	0
317	L:L:D21	L:L:Q20	3.92	No	No	0	0	0
318	L:L:F22	L:L:W25	4.01	Yes	No	1	0	0
319	L:L:F22	L:L:L26	13.4	Yes	Yes	1	0	0
320	L:L:E27	L:L:V23	4.28	Yes	Yes	1	0	0
321	L:L:L26	L:L:W25	4.56	Yes	No	1	0	0
322	R:R:D74	R:R:P56	3.22	No	No	0	3	1
323	R:R:R102	R:R:R121	3.2	Yes	No	0	8	6
324	L:L:S2	L:L:T5	3.2	No	No	0	0	0
325	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
326	R:R:C403	R:R:L166	3.17	Yes	No	0	9	8
327	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
328	R:R:A208	R:R:L217	3.15	No	No	0	4	4
329	R:R:A209	R:R:L217	3.15	No	No	0	1	4
330	R:R:A316	R:R:L245	3.15	No	No	0	7	8
331	R:R:I161	R:R:V160	3.07	No	No	0	4	3
332	R:R:I323	R:R:V249	3.07	No	No	0	8	6
333	R:R:I272	R:R:V276	3.07	No	No	0	6	3
334	R:R:I308	R:R:V287	3.07	No	No	0	8	4
335	R:R:I323	R:R:V319	3.07	No	No	0	8	6
336	R:R:I328	R:R:T353	3.04	No	No	0	7	9
337	R:R:K336	R:R:V332	3.04	No	No	0	6	6
338	R:R:F369	R:R:G318	3.01	Yes	No	0	4	4
339	R:R:L181	R:R:S163	3	No	No	0	6	6
340	R:R:L245	R:R:V319	2.98	No	No	0	8	6
341	R:R:L254	R:R:V259	2.98	No	No	0	8	6
342	R:R:L278	R:R:V282	2.98	No	No	0	3	3
343	R:R:L356	R:R:V327	2.98	Yes	No	0	9	9
344	R:R:L349	R:R:V332	2.98	No	No	0	9	6
345	R:R:L401	R:R:T355	2.95	No	No	0	8	8
346	L:L:T5	R:R:L384	2.95	No	No	0	0	5
347	R:R:I330	R:R:K334	2.91	No	No	0	9	9
348	R:R:Q97	R:R:V95	2.87	No	No	0	4	5
349	R:R:E128	R:R:V95	2.85	No	No	0	3	5
350	R:R:I400	R:R:L396	2.85	No	No	0	6	7
351	R:R:K113	R:R:L118	2.82	No	No	0	4	4
352	R:R:L218	R:R:L32	2.77	No	No	0	3	4
353	R:R:A191	R:R:F156	2.77	No	Yes	0	7	7
354	R:R:A200	R:R:F230	2.77	No	Yes	0	4	5
355	R:R:C226	R:R:Y220	2.69	No	No	0	9	3
356	R:R:E127	R:R:L123	2.65	No	No	0	2	5
357	R:R:E408	R:R:N406	2.63	No	No	0	9	9
358	R:R:R102	R:R:V100	2.62	Yes	No	0	8	7
359	R:R:F184	R:R:V398	2.62	No	No	0	8	9
360	R:R:F187	R:R:V398	2.62	Yes	No	0	8	9
361	R:R:F230	R:R:V229	2.62	Yes	No	0	5	7
362	R:R:F280	R:R:V281	2.62	No	No	0	5	6
363	R:R:D67	R:R:E68	2.6	No	No	0	9	4
364	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
365	R:R:F381	R:R:T378	2.59	No	No	0	4	2
366	R:R:S223	R:R:Y220	2.54	No	No	0	4	3
367	R:R:F266	R:R:I179	2.51	No	No	0	6	8
368	R:R:F367	R:R:I382	2.51	Yes	No	0	7	4
369	R:R:T253	R:R:Y269	2.5	No	Yes	0	7	7
370	R:R:K351	R:R:R348	2.48	No	No	0	8	8
371	R:R:V270	R:R:W243	2.45	No	Yes	9	5	9
372	R:R:V270	R:R:W274	2.45	No	Yes	9	5	9
373	R:R:F385	R:R:L144	2.44	Yes	No	0	6	6
374	R:R:L335	R:R:R348	2.43	No	No	0	8	8
375	R:R:L401	R:R:Y402	2.34	No	No	0	8	8
376	R:R:E41	R:R:R44	2.33	No	No	0	4	3
377	L:L:E12	R:R:R299	2.33	No	No	0	0	4
378	R:R:E418	R:R:R421	2.33	No	No	0	4	4
379	R:R:F381	R:R:F385	2.14	No	Yes	0	4	6
380	R:R:G78	R:R:P77	2.03	No	Yes	0	7	4
381	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
382	R:R:R421	R:R:W420	2	No	No	0	4	4
383	R:R:C296	R:R:G295	1.96	Yes	No	0	9	4
384	R:R:P54	R:R:P55	1.95	No	No	0	2	1
385	R:R:P55	R:R:P56	1.95	No	No	0	1	1
386	R:R:A57	R:R:G75	1.95	No	No	0	1	7
387	R:R:G216	R:R:S219	1.86	No	No	0	2	5
388	R:R:G361	R:R:T362	1.82	No	No	0	9	7
389	R:R:A158	R:R:A399	1.79	No	No	0	7	8
390	L:L:A24	L:L:A28	1.79	No	No	0	0	0
391	L:L:V23	R:R:P90	1.77	Yes	No	0	0	4
392	R:R:A209	R:R:S206	1.71	No	No	0	1	4
393	R:R:G216	R:R:L217	1.71	No	No	0	2	4
394	R:R:G248	R:R:L251	1.71	No	No	0	8	9
395	L:L:A19	R:R:T35	1.68	No	No	0	0	5
396	R:R:M397	R:R:P358	1.68	No	No	0	5	9
397	R:R:E107	R:R:G108	1.64	No	No	0	5	9
398	R:R:C341	R:R:I345	1.64	No	No	0	4	5
399	R:R:S223	R:R:S225	1.63	No	No	0	4	3
400	L:L:S16	R:R:V30	1.62	No	No	0	0	2
401	R:R:T149	R:R:V150	1.59	No	No	0	7	5
402	L:L:A28	R:R:L123	1.58	No	No	0	0	5
403	R:R:E138	R:R:P137	1.57	No	No	0	2	3
404	R:R:C341	R:R:N338	1.57	No	No	0	4	6
405	R:R:C347	R:R:D344	1.56	No	No	0	7	7
406	R:R:I272	R:R:S271	1.55	No	No	0	6	3
407	R:R:I196	R:R:V229	1.54	No	No	0	5	7
408	R:R:I400	R:R:V405	1.54	No	No	0	6	6
409	R:R:M233	R:R:S193	1.53	No	No	0	6	6
410	R:R:A208	R:R:Q211	1.52	No	No	0	4	4
411	L:L:S8	R:R:N300	1.49	No	No	0	0	6
412	R:R:L335	R:R:V331	1.49	No	No	0	8	8
413	R:R:D222	R:R:S219	1.47	No	No	0	6	5
414	R:R:L354	R:R:T353	1.47	No	No	0	8	9
415	L:L:D9	L:L:S8	1.47	No	No	0	0	0
416	L:L:D15	L:L:S16	1.47	No	No	0	0	0
417	R:R:E128	R:R:S94	1.44	No	No	0	3	4
418	R:R:I330	R:R:L255	1.43	No	No	0	9	8
419	R:R:I328	R:R:L356	1.43	No	Yes	0	7	9
420	R:R:I357	R:R:L354	1.43	No	No	0	8	8
421	R:R:K346	R:R:L349	1.41	No	No	0	6	9
422	R:R:L379	R:R:M371	1.41	No	Yes	0	3	7
423	R:R:K415	R:R:L411	1.41	No	No	0	7	4
424	R:R:A153	R:R:F195	1.39	No	No	0	6	7
425	R:R:L254	R:R:L255	1.38	No	No	0	8	8
426	R:R:L109	R:R:N115	1.37	No	No	0	5	4
427	R:R:L339	R:R:N338	1.37	No	No	0	7	6
428	R:R:E139	R:R:L142	1.33	No	No	0	2	3
429	R:R:E418	R:R:L422	1.33	No	No	0	4	4
430	R:R:N407	R:R:Q410	1.32	No	No	0	6	7
431	R:R:F324	R:R:V325	1.31	No	No	0	9	5
432	R:R:E408	R:R:N407	1.31	No	No	0	9	6
433	R:R:F143	R:R:I147	1.26	No	No	0	4	6
434	R:R:K415	R:R:R419	1.24	No	No	0	7	7
435	R:R:F143	R:R:F385	1.07	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	13.6225	4	1	5
2	R:R:Y42	11.72	4	1	6
3	R:R:Q45	9.115	4	1	5
4	R:R:R64	10.8425	4	2	4
5	R:R:F66	7.015	4	10	7
6	R:R:Y69	11.345	4	0	6
7	R:R:P77	4.452	5	2	4
8	R:R:P86	5.514	5	1	8
9	R:R:Y88	7.87143	7	1	5
10	R:R:L89	6.98	5	1	5
11	R:R:Y101	9.94	5	4	5
12	R:R:R102	8.285	4	2	8
13	R:R:W110	8.20833	6	2	9
14	R:R:E125	5.895	4	4	5
15	R:R:Y148	5.9125	4	0	7
16	R:R:Y152	7.29	5	0	7
17	R:R:F156	5.77	4	14	7
18	R:R:L159	3.7725	4	13	9
19	R:R:R176	5.135	4	8	9
20	R:R:N177	5.3625	4	8	9
21	R:R:H180	5.945	4	8	9
22	R:R:F187	7.23833	6	13	8
23	R:R:R190	7.6825	4	0	8
24	R:R:K197	5.1725	4	0	6
25	R:R:Y205	4.73667	6	16	3
26	R:R:F230	5.242	5	0	5
27	R:R:Y242	6.26	5	6	6
28	R:R:W243	10.1383	6	9	9
29	R:R:Y269	4.554	5	0	7
30	R:R:W274	7.976	5	9	9
31	R:R:P277	4.41	4	6	9
32	R:R:W284	11.138	5	3	8
33	R:R:K288	12.75	4	3	8
34	R:R:E292	9.345	4	3	6
35	R:R:C296	4.5725	4	0	9
36	R:R:W297	12.0275	4	0	8
37	R:R:Y305	10.365	4	3	4
38	R:R:W306	16.7125	4	0	6
39	R:R:R310	10.84	5	7	6
40	R:R:L356	3.6625	4	0	9
41	R:R:H363	7.0975	4	5	8
42	R:R:E364	7.6775	4	5	8
43	R:R:F367	4.4225	4	0	7
44	R:R:F369	4.9025	4	0	4
45	R:R:M371	5.99	4	0	7
46	R:R:E373	10.66	4	7	4
47	R:R:F385	3.395	4	0	6
48	R:R:C403	3.56	4	0	9
49	R:R:E412	10.2425	4	15	8
50	L:L:H1	6.835	4	0	0
51	L:L:F22	8.538	5	1	0
52	L:L:V23	4.598	5	1	0
53	L:L:L26	9.94	4	1	0
54	L:L:E27	5.29	5	1	0
55	L:L:?1	10.3462	8	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L218	R:R:W33	95.2025	3.42	No	No	0	3	3
2	R:R:S31	R:R:W33	95.5741	3.71	No	No	0	4	3
3	R:R:L218	R:R:V36	94.4552	7.45	No	No	0	3	2
4	L:L:F22	R:R:V36	94.0794	5.24	Yes	No	0	0	2
5	L:L:F22	R:R:W39	51.5132	10.02	Yes	Yes	1	0	5
6	R:R:W39	R:R:Y88	41.9861	12.54	Yes	Yes	1	5	5
7	L:L:F22	L:L:L26	41.3096	13.4	Yes	Yes	1	0	0
8	L:L:L26	R:R:Y88	40.9666	5.86	Yes	Yes	1	0	5
9	R:R:E41	R:R:R44	11.1803	2.33	No	No	0	4	3
10	R:R:Y42	R:R:Y88	17.2258	14.89	Yes	Yes	1	6	5
11	R:R:R43	R:R:W39	11.4017	15.99	No	Yes	0	4	5
12	R:R:C46	R:R:R43	10.8452	4.18	No	No	0	8	4
13	R:R:C46	R:R:C71	10.2872	7.28	No	No	0	8	9
14	R:R:R64	R:R:W110	20.483	7	Yes	Yes	2	4	9
15	R:R:R64	R:R:Y69	44.118	20.58	Yes	Yes	0	4	6
16	L:L:E27	R:R:Y69	48.2882	3.37	Yes	Yes	0	0	6
17	L:L:E27	R:R:Y88	50.3972	10.1	Yes	Yes	1	0	5
18	R:R:R102	R:R:R64	21.5553	5.33	Yes	Yes	2	8	4
19	R:R:F103	R:R:F80	10.9874	13.93	No	No	0	4	4
20	R:R:F103	R:R:L111	12.0783	3.65	No	No	0	4	4
21	R:R:L111	R:R:W120	13.1678	11.39	No	No	0	4	5
22	R:R:R121	R:R:W120	14.2559	5	No	No	0	6	5
23	R:R:R102	R:R:R121	19.6749	3.2	Yes	No	0	8	6
24	L:L:E17	L:L:Y13	11.9783	10.1	No	No	0	0	0
25	L:L:Y13	R:R:E138	12.482	16.83	No	No	0	0	2
26	R:R:E138	R:R:L141	13.485	6.63	No	No	0	2	5
27	L:L:F6	R:R:L141	13.9844	3.65	No	No	0	0	5
28	L:L:F6	R:R:Y148	18.4147	8.25	No	Yes	0	0	7
29	R:R:D198	R:R:Y148	98.5747	5.75	No	Yes	0	7	7
30	R:R:D198	R:R:K197	99.6571	6.91	No	Yes	0	7	6
31	R:R:F230	R:R:K197	100	4.96	Yes	Yes	0	5	6
32	R:R:C296	R:R:F230	50.733	4.19	Yes	Yes	0	9	5
33	R:R:C296	R:R:M204	50.0129	4.86	Yes	No	0	9	3
34	R:R:M204	R:R:Y205	49.6564	5.99	No	Yes	16	3	3
35	L:L:D15	R:R:Y205	97.7731	5.75	No	Yes	0	0	3
36	L:L:D15	R:R:S31	96.68	4.42	No	No	0	0	4
37	R:R:F230	R:R:T298	49.5078	11.67	Yes	No	0	5	5
38	L:L:S11	R:R:T298	49.402	4.8	No	No	0	0	5
39	L:L:S11	R:R:Y205	49.0934	5.09	No	Yes	0	0	3
40	R:R:Y148	R:R:Y152	92.3334	4.96	Yes	Yes	0	7	7
41	R:R:R190	R:R:Y152	91.3646	9.26	Yes	Yes	0	8	7
42	R:R:F187	R:R:N240	63.8994	18.12	Yes	No	0	8	9
43	R:R:N240	R:R:R190	78.2553	8.44	No	Yes	0	9	8
44	R:R:A162	R:R:C403	59.9264	3.61	No	Yes	0	9	9
45	R:R:A162	R:R:F184	60.7452	4.16	No	No	0	9	8
46	R:R:F184	R:R:L159	30.8845	4.87	No	Yes	0	8	9
47	R:R:F187	R:R:L159	31.9254	3.65	Yes	Yes	13	8	9
48	R:R:F184	R:R:V398	30.6816	2.62	No	No	0	8	9
49	R:R:F187	R:R:V398	31.0552	2.62	Yes	No	0	8	9
50	R:R:C403	R:R:L166	43.2686	3.17	Yes	No	0	9	8
51	R:R:L166	R:R:N177	39.865	6.87	No	Yes	0	8	9
52	R:R:E247	R:R:H180	16.9779	11.08	No	Yes	0	9	9
53	R:R:H180	R:R:N177	32.8306	3.83	Yes	Yes	8	9	9
54	R:R:N240	R:R:S186	25.1118	7.45	No	No	0	9	9
55	R:R:S186	R:R:W243	24.6446	4.94	No	Yes	0	9	9
56	R:R:G273	R:R:W243	19.8935	8.44	No	Yes	0	9	9
57	R:R:G273	R:R:I272	19.4106	3.53	No	No	0	9	6
58	R:R:I272	R:R:V276	18.4404	3.07	No	No	0	6	3
59	R:R:V276	R:R:Y242	16.4142	7.57	No	Yes	6	3	6
60	R:R:A316	R:R:Y242	14.5024	4	No	Yes	0	7	6
61	R:R:A316	R:R:L245	14.0037	3.15	No	No	0	7	8
62	R:R:L245	R:R:V319	13.0021	2.98	No	No	0	8	6
63	R:R:I323	R:R:V319	11.9947	3.07	No	No	0	8	6
64	R:R:I323	R:R:V249	10.473	3.07	No	No	0	8	6
65	R:R:H180	R:R:Y402	15.1918	4.36	Yes	No	0	9	8
66	R:R:R190	R:R:V237	21.7804	9.15	Yes	No	0	8	6
67	R:R:Q234	R:R:W284	11.7154	14.24	No	Yes	3	7	8
68	L:L:H1	R:R:Q234	12.7263	4.95	Yes	No	0	0	7
69	L:L:H1	R:R:V237	21.3039	9.69	Yes	No	0	0	6
70	R:R:E247	R:R:L359	12.5627	3.98	No	No	0	9	9
71	R:R:L359	R:R:Y402	12.5427	21.1	No	No	0	9	8
72	R:R:F324	R:R:L356	12.5663	6.09	No	Yes	0	9	9
73	R:R:L356	R:R:L360	21.5182	4.15	Yes	No	0	9	9
74	R:R:L359	R:R:L360	23.3021	4.15	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S31	R:R:W33	3.71	0	No	No	4	3	1	2
R:R:E34	R:R:S31	4.31	0	No	No	4	4	2	1
L:L:D15	R:R:S31	4.42	0	No	No	0	4	0	1
R:R:L218	R:R:W33	3.42	0	No	No	3	3	2	2
R:R:T35	R:R:Y88	3.75	0	No	Yes	5	5	1	1
R:R:L218	R:R:V36	7.45	0	No	No	3	2	2	1
L:L:F22	R:R:V36	5.24	1	Yes	No	0	2	0	1
R:R:R43	R:R:W39	15.99	0	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	12.54	1	Yes	Yes	5	5	1	1
L:L:F22	R:R:W39	10.02	1	Yes	Yes	0	5	0	1
L:L:L26	R:R:W39	15.94	1	Yes	Yes	0	5	0	1
R:R:P86	R:R:Y42	8.34	1	Yes	Yes	8	6	1	2
R:R:Y42	R:R:Y88	14.89	1	Yes	Yes	6	5	2	1
R:R:R64	R:R:Y69	20.58	2	Yes	Yes	4	6	2	1
R:R:D67	R:R:Y69	16.09	0	No	Yes	9	6	2	1
R:R:A70	R:R:Y69	5.34	0	No	Yes	5	6	2	1
L:L:E27	R:R:Y69	3.37	1	Yes	Yes	0	6	0	1
R:R:C85	R:R:P86	3.77	0	No	Yes	9	8	2	1
R:R:P86	R:R:Y88	4.17	1	Yes	Yes	8	5	1	1
R:R:L89	R:R:P86	6.57	1	Yes	Yes	5	8	1	1
L:L:E27	R:R:P86	4.72	1	Yes	Yes	0	8	0	1
L:L:V23	R:R:Y88	3.79	1	Yes	Yes	0	5	0	1
L:L:L26	R:R:Y88	5.86	1	Yes	Yes	0	5	0	1
L:L:E27	R:R:Y88	10.1	1	Yes	Yes	0	5	0	1
R:R:A92	R:R:L89	6.3	0	No	Yes	5	5	2	1
R:R:E127	R:R:L89	10.6	1	No	Yes	2	5	1	1
L:L:V23	R:R:L89	7.45	1	Yes	Yes	0	5	0	1
L:L:E27	R:R:L89	3.98	1	Yes	Yes	0	5	0	1
R:R:E128	R:R:W91	5.45	0	No	No	3	4	2	1
L:L:Q20	R:R:W91	18.62	0	No	No	0	4	0	1
L:L:V23	R:R:E127	5.7	1	Yes	No	0	2	0	1
R:R:E138	R:R:L141	6.63	0	No	No	2	5	1	1
L:L:Y13	R:R:E138	16.83	0	No	No	0	2	0	1
L:L:F6	R:R:L141	3.65	0	No	No	0	5	0	1
R:R:I146	R:R:L142	4.28	0	No	No	4	3	1	2
L:L:F6	R:R:L144	3.65	0	No	No	0	6	0	1
R:R:D198	R:R:Y145	6.9	0	No	No	7	5	2	1
L:L:?1	R:R:Y145	23.3	0	Yes	No	0	5	0	1
L:L:?1	R:R:I146	4.05	0	Yes	No	0	4	0	1
R:R:Y148	R:R:Y152	4.96	0	Yes	Yes	7	7	1	1
R:R:D198	R:R:Y148	5.75	0	No	Yes	7	7	2	1
R:R:L388	R:R:Y148	4.69	0	No	Yes	7	7	1	1
L:L:F6	R:R:Y148	8.25	0	No	Yes	0	7	0	1
L:L:?1	R:R:T149	4.18	0	Yes	No	0	7	0	1
R:R:R190	R:R:Y152	9.26	0	Yes	Yes	8	7	2	1
R:R:V194	R:R:Y152	10.09	0	No	Yes	7	7	2	1
R:R:S392	R:R:Y152	7.63	12	No	Yes	9	7	2	1
L:L:Q3	R:R:Y152	4.51	0	No	Yes	0	7	0	1
L:L:?1	R:R:A153	4.47	0	Yes	No	0	6	0	1
L:L:?1	R:R:L154	10.48	0	Yes	No	0	5	0	1
L:L:?1	R:R:S157	4.26	0	Yes	No	0	3	0	1
R:R:R190	R:R:V237	9.15	0	Yes	No	8	6	2	1
R:R:D198	R:R:K197	6.91	0	No	Yes	7	6	2	1
R:R:F230	R:R:K197	4.96	0	Yes	Yes	5	6	2	1
R:R:K197	R:R:M233	4.32	0	Yes	No	6	6	1	2
L:L:T7	R:R:K197	4.5	0	No	Yes	0	6	0	1
R:R:L201	R:R:Y205	3.52	0	No	Yes	7	3	2	1
R:R:K202	R:R:T207	16.52	0	No	No	4	3	1	2
L:L:?1	R:R:K202	20.02	0	Yes	No	0	4	0	1
R:R:M204	R:R:Y205	5.99	16	No	Yes	3	3	2	1
R:R:M204	R:R:Q221	16.31	16	No	No	3	4	2	2
R:R:Q221	R:R:Y205	3.38	16	No	Yes	4	3	2	1
L:L:S11	R:R:Y205	5.09	0	No	Yes	0	3	0	1
L:L:L14	R:R:Y205	4.69	0	No	Yes	0	3	0	1
L:L:D15	R:R:Y205	5.75	0	No	Yes	0	3	0	1
L:L:R18	R:R:S206	11.86	0	No	No	0	4	0	1
L:L:F22	R:R:W214	10.02	1	Yes	No	0	1	0	1
L:L:W25	R:R:W214	32.8	1	No	No	0	1	0	1
R:R:F230	R:R:T298	11.67	0	Yes	No	5	5	2	1
R:R:Q234	R:R:W284	14.24	3	No	Yes	7	8	1	2
R:R:I309	R:R:Q234	6.86	3	No	No	7	7	2	1
L:L:H1	R:R:Q234	4.95	0	Yes	No	0	7	0	1
L:L:H1	R:R:V237	9.69	0	Yes	No	0	6	0	1
R:R:I309	R:R:W284	15.27	3	No	Yes	7	8	2	2
L:L:S11	R:R:T298	4.8	0	No	No	0	5	0	1
L:L:S11	R:R:R299	5.27	0	No	No	0	4	0	1
R:R:N300	R:R:W306	27.12	0	No	Yes	6	6	1	1
R:R:I309	R:R:W306	8.22	3	No	Yes	7	6	2	1
R:R:R310	R:R:W306	21.99	7	Yes	Yes	6	6	2	1
L:L:H1	R:R:W306	9.52	0	Yes	Yes	0	6	0	1
R:R:A368	R:R:E387	4.53	0	No	No	6	8	2	1
R:R:R376	R:R:R380	4.26	0	No	No	5	5	2	1
L:L:D9	R:R:R380	4.76	0	No	No	0	5	0	1
R:R:E387	R:R:K383	6.75	0	No	No	8	7	1	2
L:L:S2	R:R:E387	12.94	0	No	No	0	8	0	1
L:L:S2	R:R:L388	4.5	0	No	No	0	7	0	1
L:L:T5	R:R:L384	2.95	0	No	No	0	5	0	1
R:R:E127	R:R:L123	2.65	1	No	No	2	5	1	1
R:R:F385	R:R:L144	2.44	0	Yes	No	6	6	2	1
L:L:E12	R:R:R299	2.33	0	No	No	0	4	0	1
L:L:V23	R:R:P90	1.77	1	Yes	No	0	4	0	1
R:R:A209	R:R:S206	1.71	0	No	No	1	4	2	1
L:L:A19	R:R:T35	1.68	0	No	No	0	5	0	1
L:L:S16	R:R:V30	1.62	0	No	No	0	2	0	1
R:R:T149	R:R:V150	1.59	0	No	No	7	5	1	2
L:L:A28	R:R:L123	1.58	0	No	No	0	5	0	1
R:R:E138	R:R:P137	1.57	0	No	No	2	3	1	2
L:L:S8	R:R:N300	1.49	0	No	No	0	6	0	1
R:R:A153	R:R:F195	1.39	0	No	No	6	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JIP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.27
Number of Linked Nodes	389
Number of Links	435
Number of Hubs	55
Number of Links mediated by Hubs	208
Number of Communities	16
Number of Nodes involved in Communities	82
Number of Links involved in Communities	106

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	201690
Length Of Smallest Path	3
Average Path Length	24.8384
Length of Longest Path	47
Minimum Path Strength	1.165
Average Path Strength	6.76069
Maximum Path Strength	24.555
Minimum Path Correlation	0.72
Average Path Correlation	0.962629
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	52.8592
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.207
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • cellular macromolecule localization • establishment of localization in cell • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein localization to membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • cellular anatomical structure • membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • amide transport • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • regulation of insulin secretion • peptide hormone secretion • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	D6M
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	D6M
Name	N-hexadecanoyl-L-glutamic acid
Synonyms
Identifier
Formula	C21 H39 N O5
Molecular Weight	385.538
SMILES
PubChem	161955
Formal Charge	0
Total Atoms	66
Total Chiral Atoms	1
Total Bonds	65
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>8JIP_nogp_Chain_R V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L M C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378

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