CodeHNO
NameN-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
Synonyms
Identifier~{N}-~{tert}-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
FormulaC12 H13 Cl2 N3
Molecular Weight270.158
SMILESCC(C)(C)Nc1cnc2cc(c(cc2n1)Cl)Cl
PubChem156022738
Formal Charge0
Total Atoms30
Total Chiral Atoms0
Total Bonds31
Total Aromatic Bonds11
Networks4
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This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DUQ B1 Peptide Glucagon GLP-1 Homo sapiens GLP-1 PubChem 156022738 Gs/Beta1/Gamma2 2.5 2021-07-14 10.1038/s41467-021-24058-z

A 2D representation of the interactions of HNO in 7DUQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C347 W:W:?1 39.17 0 No Yes 7 0 1 0
R:R:K351 R:R:R348 9.9 0 No No 8 8 1 2
R:R:A350 W:W:?1 13.89 0 No Yes 8 0 1 0
R:R:K346 W:W:?1 2.49 0 No Yes 6 0 1 0
R:R:K351 W:W:?1 2.49 0 No Yes 8 0 1 0
R:R:K351 R:R:T355 1.5 0 No No 8 8 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength14.51
Average Nodes In Shell7.00
Average Hubs In Shell1.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DUR B1 Peptide Glucagon GLP-1 Homo sapiens - PubChem 156022738 Gs/Beta1/Gamma2 3.3 2021-08-11 10.1038/s41467-021-24058-z

A 2D representation of the interactions of HNO in 7DUR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C347 W:W:?1 33.57 0 No No 7 0 1 0
R:R:C347 R:R:D344 1.56 0 No No 7 7 1 2
StatisticsValue
Average Number Of Links1.00
Average Number Of Links With An Hub0.00
Average Interaction Strength33.57
Average Nodes In Shell3.00
Average Hubs In Shell0.00
Average Links In Shell2.00
Average Links Mediated by Hubs In Shell0.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E14 B1 Peptide Glucagon GLP-1 Homo sapiens Orforglipron PubChem 156022738 Gs/Beta1/Gamma2 2.9 2021-07-07 10.1038/s41467-021-24058-z

A 2D representation of the interactions of HNO in 7E14
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C347 W:W:?1 22.38 0 No No 7 0 1 0
R:R:L354 W:W:?1 2.44 0 No No 8 0 1 0
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub0.00
Average Interaction Strength12.41
Average Nodes In Shell3.00
Average Hubs In Shell0.00
Average Links In Shell2.00
Average Links Mediated by Hubs In Shell0.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EVM B1 Peptide Glucagon GLP-1 Homo sapiens - PubChem 156022738 Gs/Beta1/Gamma2 2.5 2021-08-11 10.1038/s41467-021-24058-z

A 2D representation of the interactions of HNO in 7EVM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C347 W:W:?1 36.37 0 No No 7 0 1 0
R:R:A350 W:W:?1 8.33 0 No No 8 0 1 0
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub0.00
Average Interaction Strength22.35
Average Nodes In Shell3.00
Average Hubs In Shell0.00
Average Links In Shell2.00
Average Links Mediated by Hubs In Shell0.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links2.25
Average Number Of Links With An Hub0.00
Average Interaction Strength20.71
Average Nodes In Shell4.00
Average Hubs In Shell0.25
Average Links In Shell3.00
Average Links Mediated by Hubs In Shell1.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)