psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E100	L:L:H98	4.92	No	Yes	1	7	9
2	L:L:G101	L:L:H98	3.18	No	Yes	0	9	9
3	L:L:H98	R:R:Q234	6.18	Yes	No	0	9	7
4	L:L:H98	R:R:V237	16.61	Yes	No	1	9	6
5	L:L:H98	R:R:Y241	3.27	Yes	Yes	1	9	8
6	L:L:H98	R:R:W306	7.41	Yes	Yes	1	9	6
7	L:L:H98	R:R:R310	3.39	Yes	Yes	1	9	6
8	L:L:A99	R:R:E387	6.03	No	No	0	8	8
9	L:L:E100	R:R:Y152	7.86	No	Yes	1	7	7
10	L:L:E100	R:R:R190	12.79	No	Yes	1	7	8
11	L:L:G101	L:L:T104	3.64	No	No	0	9	9
12	L:L:D106	L:L:T102	4.34	No	No	0	9	9
13	L:L:T102	R:R:D372	11.56	No	No	0	9	5
14	L:L:F103	R:R:L141	3.65	No	No	0	5	5
15	L:L:F103	R:R:L144	6.09	No	No	1	5	6
16	L:L:F103	R:R:L388	8.53	No	No	1	5	7
17	L:L:T104	R:R:K197	10.51	No	Yes	1	9	6
18	L:L:T104	R:R:M233	4.52	No	Yes	1	9	6
19	L:L:S105	R:R:N300	5.96	No	No	0	8	6
20	L:L:D106	R:R:R380	5.96	No	Yes	0	9	5
21	L:L:S108	R:R:Y205	5.09	No	Yes	0	9	3
22	L:L:S108	R:R:T298	6.4	No	No	0	9	5
23	L:L:S108	R:R:R299	5.27	No	Yes	0	9	4
24	L:L:S109	R:R:T29	6.4	No	No	0	7	2
25	L:L:Q114	L:L:Y110	3.38	No	Yes	10	6	7
26	L:L:Y110	R:R:P137	8.34	Yes	No	0	7	3
27	L:L:Y110	R:R:E138	11.22	Yes	No	10	7	2
28	L:L:Y110	R:R:L141	4.69	Yes	No	0	7	5
29	L:L:L111	R:R:Y205	12.89	No	Yes	0	8	3
30	L:L:E112	R:R:Y205	7.86	No	Yes	0	5	3
31	L:L:E112	R:R:R299	4.65	No	Yes	0	5	4
32	L:L:Q114	R:R:E138	3.82	No	No	10	6	2
33	L:L:K117	R:R:E128	5.4	No	No	0	8	3
34	L:L:E118	R:R:W214	7.63	No	Yes	0	7	1
35	L:L:F119	L:L:L123	9.74	Yes	Yes	2	9	9
36	L:L:F119	R:R:L32	3.65	Yes	Yes	2	9	4
37	L:L:F119	R:R:V36	3.93	Yes	No	0	9	2
38	L:L:F119	R:R:W214	14.03	Yes	Yes	2	9	1
39	L:L:I120	R:R:W91	4.7	No	Yes	0	8	4
40	L:L:K125	L:L:W122	9.28	No	No	0	5	4
41	L:L:R127	L:L:W122	8	Yes	No	0	4	4
42	L:L:W122	R:R:W214	17.81	No	Yes	0	4	1
43	L:L:L123	L:L:R127	6.07	Yes	Yes	2	9	4
44	L:L:L123	R:R:W39	5.69	Yes	Yes	2	9	5
45	L:L:L123	R:R:Y88	3.52	Yes	Yes	2	9	5
46	L:L:V124	R:R:R121	3.92	No	No	0	7	6
47	L:L:V124	R:R:L123	5.96	No	No	0	7	5
48	L:L:G126	R:R:E68	8.19	No	No	0	7	4
49	L:L:R127	R:R:W39	13	Yes	Yes	2	4	5
50	L:L:R127	R:R:E68	18.61	Yes	No	0	4	4
51	R:R:L32	R:R:Q213	3.99	Yes	No	0	4	4
52	R:R:L32	R:R:W214	4.56	Yes	Yes	2	4	1
53	R:R:Q37	R:R:W33	3.29	No	No	0	4	3
54	R:R:D222	R:R:W33	4.47	No	No	0	6	3
55	R:R:P90	R:R:T35	5.25	Yes	No	0	4	5
56	R:R:Q37	R:R:R40	7.01	No	No	0	4	2
57	R:R:K38	R:R:W87	3.48	No	No	0	4	3
58	R:R:R43	R:R:W39	12	No	Yes	2	4	5
59	R:R:W39	R:R:Y88	9.65	Yes	Yes	2	5	5
60	R:R:E41	R:R:R44	4.65	No	No	0	4	3
61	R:R:E41	R:R:Q45	6.37	No	No	0	4	5
62	R:R:W87	R:R:Y42	13.5	No	No	0	3	6
63	R:R:Y42	R:R:Y88	9.93	No	Yes	0	6	5
64	R:R:Q47	R:R:R43	8.18	No	No	2	3	4
65	R:R:F66	R:R:R43	3.21	No	No	2	7	4
66	R:R:C46	R:R:F66	6.98	No	No	0	8	7
67	R:R:C46	R:R:C71	5.46	No	No	0	8	9
68	R:R:F66	R:R:Q47	4.68	No	No	2	7	3
69	R:R:D53	R:R:S49	5.89	No	No	0	3	2
70	R:R:D53	R:R:P54	4.83	No	No	0	3	2
71	R:R:D53	R:R:R64	4.76	No	No	0	3	4
72	R:R:P56	R:R:T58	3.5	Yes	No	9	1	1
73	R:R:F61	R:R:P56	14.45	Yes	Yes	9	3	1
74	R:R:P56	R:R:R64	5.76	Yes	No	0	1	4
75	R:R:D74	R:R:P56	4.83	Yes	Yes	9	3	1
76	R:R:F61	R:R:T58	14.27	Yes	No	9	3	1
77	R:R:D74	R:R:T58	7.23	Yes	No	9	3	1
78	R:R:D59	R:R:L60	4.07	No	No	0	3	1
79	R:R:L60	R:R:P77	11.49	No	No	0	1	4
80	R:R:D74	R:R:F61	16.72	Yes	Yes	9	3	3
81	R:R:C104	R:R:C62	3.64	No	No	3	9	9
82	R:R:C62	R:R:W110	11.75	No	Yes	3	9	9
83	R:R:T65	R:R:W110	6.06	No	Yes	0	5	9
84	R:R:D67	R:R:W72	11.17	No	Yes	3	9	9
85	R:R:D67	R:R:R102	5.96	No	Yes	3	9	8
86	R:R:D67	R:R:R121	5.96	No	No	0	9	6
87	R:R:E68	R:R:L118	3.98	No	No	0	4	4
88	R:R:P86	R:R:Y69	6.95	Yes	No	2	8	6
89	R:R:L89	R:R:Y69	5.86	Yes	No	2	5	6
90	R:R:L123	R:R:Y69	9.38	No	No	0	5	6
91	R:R:V81	R:R:W72	4.9	No	Yes	0	6	9
92	R:R:V83	R:R:W72	4.9	No	Yes	3	5	9
93	R:R:V100	R:R:W72	8.58	No	Yes	3	7	9
94	R:R:R102	R:R:W72	31.99	Yes	Yes	3	8	9
95	R:R:P73	R:R:V83	3.53	No	No	0	5	5
96	R:R:D74	R:R:G75	5.03	Yes	No	0	3	7
97	R:R:F103	R:R:F80	37.51	No	No	4	4	4
98	R:R:F80	R:R:W120	9.02	No	Yes	4	4	5
99	R:R:N82	R:R:Y101	13.96	No	Yes	0	4	5
100	R:R:V100	R:R:V83	3.21	No	No	3	7	5
101	R:R:H99	R:R:S84	4.18	No	No	0	4	4
102	R:R:C85	R:R:P86	3.77	No	Yes	0	9	8
103	R:R:C126	R:R:C85	5.46	No	No	0	9	9
104	R:R:P86	R:R:Y88	5.56	Yes	Yes	2	8	5
105	R:R:L89	R:R:P86	4.93	Yes	Yes	2	5	8
106	R:R:L89	R:R:Y88	3.52	Yes	Yes	2	5	5
107	R:R:L89	R:R:W91	13.67	Yes	Yes	0	5	4
108	R:R:P90	R:R:W91	5.4	Yes	Yes	0	4	4
109	R:R:V95	R:R:W91	3.68	No	Yes	0	5	4
110	R:R:E128	R:R:W91	14.17	No	Yes	0	3	4
111	R:R:S129	R:R:S94	3.26	No	No	0	1	4
112	R:R:S129	R:R:V95	8.08	No	No	0	1	5
113	R:R:D122	R:R:Y101	9.2	No	Yes	4	7	5
114	R:R:E125	R:R:Y101	8.98	Yes	Yes	4	5	5
115	R:R:R102	R:R:W110	17.99	Yes	Yes	3	8	9
116	R:R:P119	R:R:R102	11.53	No	Yes	3	6	8
117	R:R:F103	R:R:L111	10.96	No	No	4	4	4
118	R:R:F103	R:R:W120	5.01	No	Yes	4	4	5
119	R:R:C104	R:R:W110	6.53	No	Yes	3	9	9
120	R:R:E107	R:R:T105	15.52	No	No	0	5	4
121	R:R:E107	R:R:L109	3.98	No	No	0	5	5
122	R:R:P119	R:R:W110	4.05	No	Yes	3	6	9
123	R:R:L111	R:R:W120	5.69	No	Yes	4	4	5
124	R:R:D114	R:R:K113	5.53	No	No	0	4	4
125	R:R:K113	R:R:S116	10.71	No	No	0	4	5
126	R:R:K113	R:R:W120	3.48	No	Yes	0	4	5
127	R:R:L118	R:R:P119	4.93	No	No	0	4	6
128	R:R:L118	R:R:R121	3.64	No	No	0	4	6
129	R:R:D122	R:R:W120	3.35	No	Yes	4	7	5
130	R:R:D122	R:R:E125	7.8	No	Yes	4	7	5
131	R:R:C126	R:R:L123	3.17	No	No	0	9	5
132	R:R:E125	R:R:S124	5.75	Yes	No	0	5	5
133	R:R:E127	R:R:E128	3.81	No	No	0	2	3
134	R:R:P137	R:R:Q140	3.16	No	Yes	0	3	4
135	R:R:L141	R:R:Q140	11.98	No	Yes	0	5	4
136	R:R:L144	R:R:Q140	3.99	No	Yes	0	6	4
137	R:R:F381	R:R:Q140	5.86	No	Yes	0	4	4
138	R:R:F143	R:R:I147	11.3	No	No	0	4	6
139	R:R:L144	R:R:L388	4.15	No	No	1	6	7
140	R:R:Y145	R:R:Y148	5.96	Yes	Yes	1	5	7
141	R:R:T149	R:R:Y145	11.24	No	Yes	1	7	5
142	R:R:D198	R:R:Y145	13.79	No	Yes	1	7	5
143	R:R:I147	R:R:S389	4.64	No	No	0	6	5
144	R:R:T149	R:R:Y148	4.99	No	Yes	1	7	7
145	R:R:Y148	R:R:Y152	4.96	Yes	Yes	1	7	7
146	R:R:V194	R:R:Y148	6.31	No	Yes	1	7	7
147	R:R:K197	R:R:Y148	4.78	Yes	Yes	1	6	7
148	R:R:D198	R:R:Y148	10.34	No	Yes	1	7	7
149	R:R:L388	R:R:Y148	7.03	No	Yes	1	7	7
150	R:R:G151	R:R:S392	3.71	No	No	1	8	9
151	R:R:F393	R:R:G151	9.03	No	No	1	7	8
152	R:R:R190	R:R:Y152	8.23	Yes	Yes	1	8	7
153	R:R:A191	R:R:Y152	4	No	Yes	0	7	7
154	R:R:V194	R:R:Y152	11.36	No	Yes	1	7	7
155	R:R:S392	R:R:Y152	7.63	No	Yes	1	9	7
156	R:R:L154	R:R:L396	4.15	No	No	0	5	7
157	R:R:L159	R:R:S155	4.5	Yes	No	1	9	9
158	R:R:G395	R:R:S155	3.71	No	No	1	9	9
159	R:R:F156	R:R:V160	7.87	No	No	1	7	3
160	R:R:F156	R:R:I188	3.77	No	No	1	7	7
161	R:R:F156	R:R:L192	7.31	No	No	0	7	3
162	R:R:F184	R:R:L159	6.09	No	Yes	0	8	9
163	R:R:F187	R:R:L159	3.65	Yes	Yes	1	8	9
164	R:R:G395	R:R:L159	3.42	No	Yes	1	9	9
165	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
166	R:R:I188	R:R:V160	4.61	No	No	1	7	3
167	R:R:F404	R:R:I161	3.77	No	No	0	8	4
168	R:R:A162	R:R:C403	3.61	No	Yes	0	9	9
169	R:R:C403	R:R:I165	3.27	Yes	No	0	9	8
170	R:R:F413	R:R:I165	10.05	No	No	0	5	8
171	R:R:L166	R:R:L181	6.92	No	No	0	8	6
172	R:R:F184	R:R:L166	3.65	No	No	0	8	8
173	R:R:C403	R:R:L166	3.17	Yes	No	0	9	8
174	R:R:L167	R:R:L181	5.54	No	No	0	3	6
175	R:R:F169	R:R:L172	4.87	Yes	No	0	7	9
176	R:R:E412	R:R:F169	8.16	No	Yes	0	8	7
177	R:R:F169	R:R:F413	8.57	Yes	No	0	7	5
178	R:R:E412	R:R:H171	11.08	No	No	0	8	7
179	R:R:H173	R:R:Y178	8.71	No	No	0	7	6
180	R:R:C174	R:R:N177	4.72	No	No	0	8	9
181	R:R:E262	R:R:T175	9.88	No	No	0	6	7
182	R:R:H180	R:R:R176	5.64	Yes	No	0	9	9
183	R:R:R176	R:R:Y250	3.09	No	No	0	9	8
184	R:R:H180	R:R:N177	3.83	Yes	No	0	9	9
185	R:R:F266	R:R:Y178	6.19	Yes	No	0	6	6
186	R:R:I179	R:R:W243	4.7	Yes	Yes	5	8	9
187	R:R:I179	R:R:V246	3.07	Yes	Yes	5	8	8
188	R:R:E247	R:R:I179	5.47	No	Yes	0	9	8
189	R:R:E247	R:R:H180	6.15	No	Yes	0	9	9
190	R:R:H180	R:R:Y402	8.71	Yes	No	0	9	8
191	R:R:N182	R:R:W243	15.82	No	Yes	5	9	9
192	R:R:N182	R:R:W274	5.65	No	Yes	5	9	9
193	R:R:F187	R:R:L183	7.31	Yes	No	1	8	9
194	R:R:L183	R:R:L244	4.15	No	No	1	9	9
195	R:R:F184	R:R:V398	3.93	No	No	0	8	9
196	R:R:N240	R:R:S186	7.45	No	No	0	9	9
197	R:R:S186	R:R:W243	4.94	No	Yes	0	9	9
198	R:R:F187	R:R:N240	15.71	Yes	No	0	8	9
199	R:R:F187	R:R:L244	4.87	Yes	No	1	8	9
200	R:R:F187	R:R:Q394	4.68	Yes	Yes	1	8	9
201	R:R:F187	R:R:G395	4.52	Yes	No	1	8	9
202	R:R:R190	R:R:V237	13.08	Yes	No	1	8	6
203	R:R:N240	R:R:R190	9.64	No	Yes	0	9	8
204	R:R:R190	R:R:Y241	13.38	Yes	Yes	1	8	8
205	R:R:R190	R:R:T391	5.17	Yes	No	1	8	6
206	R:R:M233	R:R:S193	4.6	Yes	No	0	6	6
207	R:R:C236	R:R:S193	6.89	No	No	0	5	6
208	R:R:I196	R:R:V229	3.07	No	No	0	5	7
209	R:R:D198	R:R:K197	5.53	No	Yes	1	7	6
210	R:R:K197	R:R:L201	4.23	Yes	No	1	6	7
211	R:R:F230	R:R:K197	3.72	No	Yes	1	5	6
212	R:R:K197	R:R:M233	7.2	Yes	Yes	1	6	6
213	R:R:A200	R:R:Y220	4	No	Yes	0	4	3
214	R:R:A200	R:R:V229	5.09	No	No	0	4	7
215	R:R:F230	R:R:L201	4.87	No	No	1	5	7
216	R:R:S206	R:R:W203	3.71	No	No	0	4	3
217	R:R:M204	R:R:Y205	5.99	No	Yes	0	3	3
218	R:R:M204	R:R:Q221	5.44	No	Yes	0	3	4
219	R:R:Q210	R:R:W214	8.76	No	Yes	0	4	1
220	R:R:Q211	R:R:W214	3.29	No	Yes	0	4	1
221	R:R:Q213	R:R:S219	8.66	No	No	0	4	5
222	R:R:Q213	R:R:Q221	3.84	No	Yes	0	4	4
223	R:R:D222	R:R:L218	5.43	No	No	0	6	3
224	R:R:S223	R:R:Y220	3.82	No	Yes	0	4	3
225	R:R:C226	R:R:Y220	4.03	No	Yes	0	9	3
226	R:R:D222	R:R:Q221	9.14	No	Yes	0	6	4
227	R:R:L224	R:R:R227	6.07	No	Yes	6	3	8
228	R:R:L224	R:R:Y289	3.52	No	No	6	3	3
229	R:R:C226	R:R:C296	5.46	No	No	0	9	9
230	R:R:R227	R:R:Y289	3.09	Yes	No	6	8	3
231	R:R:D293	R:R:R227	15.48	No	Yes	6	7	8
232	R:R:C296	R:R:R227	6.96	No	Yes	0	9	8
233	R:R:R227	R:R:W297	22.99	Yes	Yes	6	8	8
234	R:R:F230	R:R:T298	15.56	No	No	0	5	5
235	R:R:L231	R:R:W297	6.83	No	Yes	0	5	8
236	R:R:C236	R:R:L232	3.17	No	No	0	5	5
237	R:R:M233	R:R:Q234	9.52	Yes	No	0	6	7
238	R:R:W274	R:R:Y235	4.82	Yes	No	0	9	9
239	R:R:L278	R:R:Y235	8.21	No	No	0	3	9
240	R:R:V237	R:R:Y241	3.79	No	Yes	1	6	8
241	R:R:I313	R:R:Y241	12.09	No	Yes	0	7	8
242	R:R:E364	R:R:Y241	4.49	No	Yes	0	8	8
243	R:R:V276	R:R:Y242	7.57	No	Yes	7	3	6
244	R:R:P277	R:R:Y242	5.56	No	Yes	7	9	6
245	R:R:F280	R:R:Y242	4.13	Yes	Yes	7	5	6
246	R:R:P312	R:R:Y242	5.56	No	Yes	7	8	6
247	R:R:T316	R:R:Y242	7.49	No	Yes	0	7	6
248	R:R:V246	R:R:W243	6.13	Yes	Yes	5	8	9
249	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
250	R:R:W243	R:R:W274	24.37	Yes	Yes	5	9	9
251	R:R:L244	R:R:Q394	3.99	No	Yes	1	9	9
252	R:R:L245	R:R:T316	7.37	No	No	0	8	7
253	R:R:V246	R:R:Y269	3.79	Yes	Yes	0	8	7
254	R:R:I272	R:R:V246	3.07	No	Yes	0	6	8
255	R:R:E247	R:R:L359	10.6	No	No	0	9	9
256	R:R:G248	R:R:I323	3.53	No	No	0	8	8
257	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
258	R:R:L254	R:R:Y250	15.24	No	No	0	8	8
259	R:R:Y250	R:R:Y269	4.96	No	Yes	0	8	7
260	R:R:L251	R:R:L255	4.15	No	No	0	9	8
261	R:R:I323	R:R:Y252	4.84	No	No	0	8	8
262	R:R:R326	R:R:Y252	6.17	No	No	0	8	8
263	R:R:T253	R:R:Y269	3.75	No	Yes	0	7	7
264	R:R:L255	R:R:V327	4.47	No	No	0	8	9
265	R:R:F260	R:R:S258	6.61	No	No	0	7	7
266	R:R:F260	R:R:I265	7.54	No	No	0	7	5
267	R:R:I265	R:R:W264	4.7	No	No	0	5	5
268	R:R:I265	R:R:Y269	7.25	No	Yes	0	5	7
269	R:R:F266	R:R:R267	5.34	Yes	No	0	6	4
270	R:R:F266	R:R:V270	3.93	Yes	No	0	6	5
271	R:R:I272	R:R:V276	4.61	No	No	0	6	3
272	R:R:P277	R:R:V276	3.53	No	No	7	9	3
273	R:R:F280	R:R:V281	3.93	Yes	No	0	5	6
274	R:R:F280	R:R:P312	13	Yes	No	7	5	8
275	R:R:P283	R:R:V282	3.53	No	No	0	5	3
276	R:R:I286	R:R:V282	3.07	No	No	0	4	3
277	R:R:G285	R:R:W284	5.63	No	No	0	5	8
278	R:R:K288	R:R:W284	6.96	No	No	0	8	8
279	R:R:I309	R:R:W284	14.09	No	No	0	7	8
280	R:R:V287	R:R:Y305	3.79	No	No	0	4	4
281	R:R:E292	R:R:K288	14.85	No	No	0	6	8
282	R:R:K288	R:R:W297	11.6	No	Yes	0	8	8
283	R:R:W297	R:R:Y289	8.68	Yes	No	6	8	3
284	R:R:L290	R:R:Y291	5.86	No	No	0	3	3
285	R:R:E292	R:R:N302	15.77	No	No	11	6	5
286	R:R:E292	R:R:Y305	5.61	No	No	11	6	4
287	R:R:D293	R:R:W297	3.35	No	Yes	6	7	8
288	R:R:M303	R:R:N300	4.21	No	No	0	5	6
289	R:R:N300	R:R:W306	14.69	No	Yes	0	6	6
290	R:R:N302	R:R:S301	5.96	No	No	0	5	3
291	R:R:N302	R:R:Y305	10.47	No	No	11	5	4
292	R:R:E373	R:R:M303	6.77	No	No	0	4	5
293	R:R:R310	R:R:W306	10	Yes	Yes	1	6	6
294	R:R:D372	R:R:W306	3.35	No	Yes	0	5	6
295	R:R:I313	R:R:R310	10.02	No	Yes	0	7	6
296	R:R:L314	R:R:R310	8.5	No	Yes	0	4	6
297	R:R:F315	R:R:V319	3.93	No	No	0	4	6
298	R:R:E364	R:R:I317	5.47	No	Yes	0	8	7
299	R:R:I317	R:R:V365	3.07	Yes	No	0	7	6
300	R:R:I323	R:R:V319	3.07	No	No	0	8	6
301	R:R:F321	R:R:V325	3.93	No	No	0	6	5
302	R:R:F321	R:R:V365	10.49	No	No	0	6	6
303	R:R:F324	R:R:I328	10.05	Yes	No	8	9	7
304	R:R:F324	R:R:T353	3.89	Yes	No	8	9	9
305	R:R:F324	R:R:L356	7.31	Yes	No	8	9	9
306	R:R:F324	R:R:L360	3.65	Yes	Yes	8	9	9
307	R:R:F324	R:R:T362	7.78	Yes	No	0	9	7
308	R:R:I328	R:R:T353	6.08	No	No	8	7	9
309	R:R:S352	R:R:V331	4.85	No	No	0	9	8
310	R:R:K336	R:R:V332	6.07	No	No	0	6	6
311	R:R:L349	R:R:V332	4.47	No	No	0	9	6
312	R:R:L335	R:R:R348	3.64	No	No	0	8	8
313	R:R:L356	R:R:L360	6.92	No	Yes	8	9	9
314	R:R:I357	R:R:P358	3.39	No	No	0	8	9
315	R:R:I357	R:R:T362	4.56	No	No	0	8	7
316	R:R:M397	R:R:P358	5.03	No	No	0	5	9
317	R:R:L359	R:R:L360	4.15	No	Yes	0	9	9
318	R:R:L359	R:R:Y402	16.41	No	No	0	9	8
319	R:R:G361	R:R:Q394	4.93	No	Yes	0	9	9
320	R:R:F390	R:R:H363	24.89	No	No	0	6	8
321	R:R:H363	R:R:T391	5.48	No	No	1	8	6
322	R:R:H363	R:R:Q394	8.65	No	Yes	1	8	9
323	R:R:E364	R:R:E387	10.15	No	No	0	8	8
324	R:R:F367	R:R:I366	3.77	Yes	No	0	7	6
325	R:R:F367	R:R:I382	3.77	Yes	No	0	7	4
326	R:R:F367	R:R:K383	3.72	Yes	No	0	7	7
327	R:R:F367	R:R:T386	7.78	Yes	No	0	7	4
328	R:R:E373	R:R:H374	8.62	No	No	0	4	3
329	R:R:R376	R:R:R380	4.26	No	Yes	0	5	5
330	R:R:L384	R:R:R380	3.64	No	Yes	0	5	5
331	R:R:E387	R:R:K383	12.15	No	No	0	8	7
332	R:R:F385	R:R:S389	5.28	No	No	0	6	5
333	R:R:F390	R:R:M397	3.73	No	No	0	6	5
334	R:R:Q394	R:R:T391	4.25	Yes	No	1	9	6
335	R:R:F393	R:R:S392	5.28	No	No	1	7	9
336	R:R:E408	R:R:N406	7.89	No	No	0	9	9
337	R:R:N406	R:R:V409	4.43	No	No	0	9	9
338	R:R:E412	R:R:K415	13.5	No	No	0	8	7
339	R:R:R414	R:R:W417	5	No	No	0	6	5
340	R:R:K415	R:R:R419	9.9	No	No	0	7	7
341	R:R:R421	R:R:W417	9	No	No	0	4	5
342	R:R:R421	R:R:W420	15.99	No	No	0	4	4
343	R:R:C296	R:R:Q221	3.05	No	Yes	0	9	4
344	R:R:K383	R:R:V370	3.04	No	No	0	7	5
345	R:R:L181	R:R:S163	3	No	No	0	6	6
346	R:R:G295	R:R:R299	3	No	Yes	0	4	4
347	L:L:L111	L:L:V107	2.98	No	No	0	8	5
348	R:R:L172	R:R:V409	2.98	No	No	0	9	9
349	R:R:L245	R:R:V319	2.98	No	No	0	8	6
350	R:R:L356	R:R:V327	2.98	No	No	0	9	9
351	R:R:L335	R:R:V331	2.98	No	No	0	8	8
352	R:R:L379	R:R:V370	2.98	No	No	0	3	5
353	R:R:L50	R:R:T51	2.95	No	No	0	4	4
354	R:R:L111	R:R:T105	2.95	No	No	0	4	4
355	R:R:I330	R:R:K334	2.91	No	No	0	9	9
356	R:R:W203	R:R:Y220	2.89	No	Yes	0	3	3
357	L:L:E112	R:R:S31	2.87	No	No	0	5	4
358	R:R:E76	R:R:S79	2.87	No	No	0	1	5
359	R:R:I146	R:R:L142	2.85	No	No	0	4	3
360	R:R:I188	R:R:L159	2.85	No	Yes	1	7	9
361	R:R:I286	R:R:L290	2.85	No	No	0	4	3
362	R:R:I400	R:R:L396	2.85	No	No	0	6	7
363	R:R:H212	R:R:S219	2.79	No	No	0	3	5
364	R:R:C403	R:R:F404	2.79	Yes	No	0	9	8
365	R:R:A238	R:R:F280	2.77	No	Yes	0	6	5
366	R:R:A368	R:R:F369	2.77	No	No	0	6	4
367	R:R:A375	R:R:R380	2.77	No	Yes	0	4	5
368	R:R:L245	R:R:N320	2.75	No	No	0	8	9
369	R:R:L360	R:R:N320	2.75	Yes	No	0	9	9
370	R:R:L411	R:R:N407	2.75	No	No	0	4	6
371	R:R:A239	R:R:Y235	2.67	No	No	0	8	9
372	R:R:A256	R:R:Y252	2.67	No	No	0	6	8
373	R:R:L50	R:R:Q47	2.66	No	No	0	4	3
374	R:R:E418	R:R:L422	2.65	No	No	0	4	4
375	R:R:H374	R:R:M371	2.63	No	No	0	3	7
376	R:R:F266	R:R:T175	2.59	Yes	No	0	6	7
377	R:R:F266	R:R:I179	2.51	Yes	Yes	0	6	8
378	R:R:F404	R:R:I400	2.51	No	No	0	8	6
379	R:R:K351	R:R:R348	2.48	No	No	0	8	8
380	R:R:S261	R:R:W264	2.47	No	No	0	7	5
381	R:R:I146	R:R:Y145	2.42	No	Yes	0	4	5
382	R:R:Q263	R:R:R267	2.34	No	No	0	5	4
383	R:R:L401	R:R:Y402	2.34	No	No	0	8	8
384	R:R:L189	R:R:W274	2.28	No	Yes	0	7	9
385	R:R:L268	R:R:W264	2.28	No	No	0	2	5
386	R:R:H173	R:R:R170	2.26	No	No	0	7	8
387	R:R:H99	R:R:Y101	2.18	No	Yes	0	4	5
388	R:R:E418	R:R:W417	2.18	No	No	0	4	5
389	R:R:F381	R:R:F385	2.14	No	No	0	4	6
390	R:R:G108	R:R:P77	2.03	No	No	0	9	4
391	R:R:G275	R:R:P277	2.03	No	No	0	6	9
392	R:R:C85	R:R:G98	1.96	No	No	0	9	4
393	R:R:C104	R:R:G108	1.96	No	No	0	9	9
394	L:L:A116	L:L:G113	1.95	No	No	0	7	5
395	R:R:P54	R:R:P55	1.95	No	No	0	2	1
396	R:R:P55	R:R:P56	1.95	No	Yes	0	1	1
397	R:R:A106	R:R:G78	1.95	No	No	0	1	7
398	L:L:A116	R:R:P90	1.87	No	Yes	0	7	4
399	R:R:A70	R:R:P86	1.87	No	Yes	0	5	8
400	R:R:G78	R:R:S79	1.86	No	No	0	7	5
401	R:R:G75	R:R:V81	1.84	No	No	0	7	6
402	R:R:G151	R:R:V150	1.84	No	No	0	8	5
403	R:R:A158	R:R:A399	1.79	No	No	0	7	8
404	R:R:P137	R:R:S136	1.78	No	No	0	3	1
405	R:R:P90	R:R:V30	1.77	Yes	No	0	4	2
406	R:R:P96	R:R:V95	1.77	No	No	0	3	5
407	R:R:G318	R:R:I317	1.76	No	Yes	0	4	7
408	R:R:A208	R:R:S206	1.71	No	No	0	4	4
409	R:R:A209	R:R:S206	1.71	No	No	0	1	4
410	R:R:A209	R:R:S219	1.71	No	No	0	1	5
411	R:R:C329	R:R:V325	1.71	No	No	0	7	5
412	R:R:G98	R:R:Q97	1.64	No	No	0	4	4
413	R:R:E125	R:R:G98	1.64	Yes	No	0	5	4
414	R:R:L311	R:R:P312	1.64	No	No	0	4	8
415	R:R:S223	R:R:S225	1.63	No	No	0	4	3
416	R:R:A368	R:R:I317	1.62	No	Yes	0	6	7
417	R:R:V327	R:R:V331	1.6	No	No	0	9	8
418	R:R:S352	R:R:T353	1.6	No	No	0	9	9
419	L:L:A115	R:R:L32	1.58	No	Yes	0	9	4
420	R:R:E76	R:R:P77	1.57	No	No	0	1	4
421	R:R:C347	R:R:D344	1.56	No	No	0	7	7
422	R:R:I161	R:R:S157	1.55	No	No	0	4	3
423	R:R:I308	R:R:V287	1.54	No	No	0	8	4
424	R:R:I400	R:R:V405	1.54	No	No	0	6	6
425	R:R:I382	R:R:T378	1.52	No	No	0	4	2
426	L:L:A121	L:L:E118	1.51	No	No	0	6	7
427	R:R:F169	R:R:G168	1.51	Yes	No	0	7	1
428	R:R:L349	R:R:S352	1.5	No	No	0	9	9
429	R:R:G377	R:R:R376	1.5	No	No	0	4	5
430	R:R:L278	R:R:V282	1.49	No	No	0	3	3
431	R:R:L401	R:R:T355	1.47	No	No	0	8	8
432	R:R:I345	R:R:K346	1.45	No	No	0	5	6
433	R:R:E34	R:R:S31	1.44	No	No	0	4	4
434	R:R:Q112	R:R:S116	1.44	No	No	0	3	5
435	R:R:I330	R:R:L255	1.43	No	No	0	9	8
436	R:R:I345	R:R:L335	1.43	No	No	0	5	8
437	R:R:I357	R:R:L354	1.43	No	No	0	8	8
438	R:R:Q211	R:R:T207	1.42	No	No	0	4	3
439	R:R:E52	R:R:T51	1.41	No	No	0	2	4
440	R:R:L307	R:R:M371	1.41	No	No	0	7	7
441	R:R:D344	R:R:I345	1.4	No	No	0	7	5
442	R:R:A153	R:R:F195	1.39	No	No	0	6	7
443	R:R:A191	R:R:F195	1.39	No	No	0	7	7
444	R:R:L228	R:R:L231	1.38	No	No	0	4	5
445	R:R:D215	R:R:L217	1.36	No	No	0	3	4
446	L:L:S109	R:R:R299	1.32	No	Yes	0	7	4
447	R:R:N407	R:R:Q410	1.32	No	No	0	6	7
448	R:R:E408	R:R:N407	1.31	No	No	0	9	6
449	R:R:F61	R:R:N63	1.21	Yes	No	0	3	4
450	R:R:Q45	R:R:R48	1.17	No	No	0	5	4
451	R:R:E52	R:R:R48	1.16	No	No	0	2	4
452	R:R:D215	R:R:W214	1.12	No	Yes	0	3	1
453	R:R:E294	R:R:W33	1.09	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H98	6.42286	7	1	9
2	L:L:Y110	6.9075	4	10	7
3	L:L:F119	7.8375	4	2	9
4	L:L:L123	6.255	4	2	9
5	L:L:R127	11.42	4	2	4
6	R:R:L32	3.445	4	2	4
7	R:R:W39	10.085	4	2	5
8	R:R:P56	6.098	5	9	1
9	R:R:F61	11.6625	4	9	3
10	R:R:W72	12.308	5	3	9
11	R:R:D74	8.4525	4	9	3
12	R:R:P86	4.616	5	2	8
13	R:R:Y88	6.436	5	2	5
14	R:R:L89	6.995	4	2	5
15	R:R:P90	3.5725	4	0	4
16	R:R:W91	8.324	5	0	4
17	R:R:Y101	8.58	4	4	5
18	R:R:R102	16.8675	4	3	8
19	R:R:W110	9.276	5	3	9
20	R:R:W120	5.31	5	4	5
21	R:R:E125	6.0425	4	4	5
22	R:R:Q140	6.2475	4	0	4
23	R:R:Y145	8.3525	4	1	5
24	R:R:Y148	6.33857	7	1	7
25	R:R:Y152	7.34	6	1	7
26	R:R:L159	3.94333	6	1	9
27	R:R:F169	5.7775	4	0	7
28	R:R:I179	3.9375	4	5	8
29	R:R:H180	6.0825	4	0	9
30	R:R:F187	6.79	6	1	8
31	R:R:R190	10.3817	6	1	8
32	R:R:K197	5.995	6	1	6
33	R:R:Y205	7.9575	4	0	3
34	R:R:W214	8.17143	7	2	1
35	R:R:Y220	3.685	4	0	3
36	R:R:Q221	5.3675	4	0	4
37	R:R:R227	10.918	5	6	8
38	R:R:M233	6.46	4	1	6
39	R:R:Y241	7.404	5	1	8
40	R:R:Y242	6.062	5	7	6
41	R:R:W243	10.7333	6	5	9
42	R:R:V246	4.015	4	5	8
43	R:R:F266	4.112	5	0	6
44	R:R:Y269	4.708	5	0	7
45	R:R:W274	9.28	4	5	9
46	R:R:F280	5.9575	4	7	5
47	R:R:W297	10.69	5	6	8
48	R:R:R299	3.56	4	0	4
49	R:R:W306	8.8625	4	1	6
50	R:R:R310	7.9775	4	1	6
51	R:R:I317	2.98	4	0	7
52	R:R:F324	6.536	5	8	9
53	R:R:L360	4.3675	4	8	9
54	R:R:F367	4.76	4	0	7
55	R:R:R380	4.1575	4	0	5
56	R:R:Q394	5.3	5	1	9
57	R:R:C403	3.21	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G101	L:L:H98	15.099	3.18	No	Yes	0	9	9
2	L:L:H98	R:R:Q234	17.237	6.18	Yes	No	0	9	7
3	L:L:H98	R:R:Y241	20.0485	3.27	Yes	Yes	1	9	8
4	R:R:R190	R:R:Y241	18.3794	13.38	Yes	Yes	1	8	8
5	L:L:H98	R:R:W306	22.1999	7.41	Yes	Yes	1	9	6
6	R:R:E364	R:R:E387	12.891	10.15	No	No	0	8	8
7	R:R:E364	R:R:Y241	24.2638	4.49	No	Yes	0	8	8
8	L:L:G101	L:L:T104	14.738	3.64	No	No	0	9	9
9	R:R:D372	R:R:W306	11.2178	3.35	No	Yes	0	5	6
10	R:R:Y148	R:R:Y152	69.7683	4.96	Yes	Yes	1	7	7
11	R:R:K197	R:R:Y148	70.7867	4.78	Yes	Yes	1	6	7
12	R:R:M233	R:R:Q234	16.8759	9.52	Yes	No	0	6	7
13	R:R:F230	R:R:K197	99.7764	3.72	No	Yes	1	5	6
14	R:R:F230	R:R:T298	100	15.56	No	No	0	5	5
15	L:L:S108	R:R:T298	99.899	6.4	No	No	0	9	5
16	L:L:S108	R:R:Y205	98.052	5.09	No	Yes	0	9	3
17	R:R:M204	R:R:Y205	98.502	5.99	No	Yes	0	3	3
18	R:R:M204	R:R:Q221	98.3592	5.44	No	Yes	0	3	4
19	R:R:Q213	R:R:Q221	91.7877	3.84	No	Yes	0	4	4
20	R:R:L32	R:R:Q213	90.6884	3.99	Yes	No	0	4	4
21	L:L:F119	R:R:L32	58.7889	3.65	Yes	Yes	2	9	4
22	L:L:F119	L:L:L123	58.762	9.74	Yes	Yes	2	9	9
23	L:L:L123	R:R:Y88	25.9922	3.52	Yes	Yes	2	9	5
24	R:R:L89	R:R:Y88	10.5119	3.52	Yes	Yes	2	5	5
25	R:R:L32	R:R:W214	31.3943	4.56	Yes	Yes	2	4	1
26	L:L:W122	R:R:W214	28.145	17.81	No	Yes	0	4	1
27	L:L:L123	L:L:R127	27.5145	6.07	Yes	Yes	2	9	4
28	L:L:R127	L:L:W122	27.5576	8	Yes	No	0	4	4
29	L:L:R127	R:R:E68	55.1111	18.61	Yes	No	0	4	4
30	R:R:E68	R:R:L118	52.9462	3.98	No	No	0	4	4
31	R:R:L118	R:R:R121	20.714	3.64	No	No	0	4	6
32	R:R:P86	R:R:Y88	14.963	5.56	Yes	Yes	2	8	5
33	R:R:L118	R:R:P119	32.7752	4.93	No	No	0	4	6
34	R:R:P119	R:R:R102	17.8351	11.53	No	Yes	3	6	8
35	R:R:R102	R:R:W72	17.0618	31.99	Yes	Yes	3	8	9
36	R:R:V81	R:R:W72	26.2845	4.9	No	Yes	0	6	9
37	R:R:G75	R:R:V81	24.1089	1.84	No	No	0	7	6
38	R:R:D74	R:R:G75	21.9305	5.03	Yes	No	0	3	7
39	R:R:D74	R:R:P56	13.1658	4.83	Yes	Yes	9	3	1
40	R:R:D67	R:R:R121	19.7225	5.96	No	No	0	9	6
41	R:R:D67	R:R:W72	17.8782	11.17	No	Yes	3	9	9
42	R:R:P119	R:R:W110	13.8273	4.05	No	Yes	3	6	9
43	R:R:C104	R:R:W110	11.141	6.53	No	Yes	3	9	9
44	R:R:C85	R:R:P86	12.6175	3.77	No	Yes	0	9	8
45	R:R:C85	R:R:G98	12.7967	1.96	No	No	0	9	4
46	R:R:E125	R:R:G98	11.5654	1.64	Yes	No	0	5	4
47	R:R:N240	R:R:R190	73.5228	9.64	No	Yes	0	9	8
48	R:R:F187	R:R:N240	28.2325	15.71	Yes	No	0	8	9
49	R:R:F187	R:R:L159	25.5853	3.65	Yes	Yes	1	8	9
50	R:R:F184	R:R:L159	20.5604	6.09	No	Yes	0	8	9
51	R:R:F184	R:R:L166	19.2644	3.65	No	No	0	8	8
52	R:R:C403	R:R:L166	16.6496	3.17	Yes	No	0	9	8
53	R:R:C403	R:R:I165	10.5874	3.27	Yes	No	0	9	8
54	R:R:N240	R:R:S186	57.2868	7.45	No	No	0	9	9
55	R:R:S186	R:R:W243	56.8315	4.94	No	Yes	0	9	9
56	R:R:I179	R:R:W243	31.5735	4.7	Yes	Yes	5	8	9
57	R:R:E247	R:R:I179	26.7277	5.47	No	Yes	0	9	8
58	R:R:V246	R:R:W243	19.1742	6.13	Yes	Yes	5	8	9
59	R:R:E247	R:R:L359	22.1164	10.6	No	No	0	9	9
60	R:R:C296	R:R:Q221	18.0399	3.05	No	Yes	0	9	4
61	R:R:C296	R:R:R227	12.2282	6.96	No	Yes	0	9	8
62	R:R:I272	R:R:V246	11.9453	3.07	No	Yes	0	6	8
63	R:R:I272	R:R:V276	11.2879	4.61	No	No	0	6	3
64	R:R:L359	R:R:L360	20.1886	4.15	No	Yes	0	9	9
65	R:R:E364	R:R:I317	10.3341	5.47	No	Yes	0	8	7
66	R:R:E387	R:R:K383	10.3341	12.15	No	No	0	8	7
67	L:L:T104	R:R:K197	14.606	10.51	No	Yes	1	9	6
68	R:R:K197	R:R:M233	16.368	7.2	Yes	Yes	1	6	6
69	R:R:R190	R:R:Y152	68.2312	8.23	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H98	R:R:Q234	6.18	1	Yes	No	9	7	0	1
L:L:H98	R:R:V237	16.61	1	Yes	No	9	6	0	1
L:L:H98	R:R:Y241	3.27	1	Yes	Yes	9	8	0	1
L:L:H98	R:R:W306	7.41	1	Yes	Yes	9	6	0	1
L:L:H98	R:R:R310	3.39	1	Yes	Yes	9	6	0	1
L:L:A99	R:R:E387	6.03	0	No	No	8	8	0	1
L:L:E100	R:R:Y152	7.86	1	No	Yes	7	7	0	1
L:L:E100	R:R:R190	12.79	1	No	Yes	7	8	0	1
L:L:T102	R:R:D372	11.56	0	No	No	9	5	0	1
L:L:F103	R:R:L141	3.65	1	No	No	5	5	0	1
L:L:F103	R:R:L144	6.09	1	No	No	5	6	0	1
L:L:F103	R:R:L388	8.53	1	No	No	5	7	0	1
L:L:T104	R:R:K197	10.51	1	No	Yes	9	6	0	1
L:L:T104	R:R:M233	4.52	1	No	Yes	9	6	0	1
L:L:S105	R:R:N300	5.96	0	No	No	8	6	0	1
L:L:D106	R:R:R380	5.96	0	No	Yes	9	5	0	1
L:L:S108	R:R:Y205	5.09	0	No	Yes	9	3	0	1
L:L:S108	R:R:T298	6.4	0	No	No	9	5	0	1
L:L:S108	R:R:R299	5.27	0	No	Yes	9	4	0	1
L:L:S109	R:R:T29	6.4	0	No	No	7	2	0	1
L:L:Y110	R:R:P137	8.34	10	Yes	No	7	3	0	1
L:L:Y110	R:R:E138	11.22	10	Yes	No	7	2	0	1
L:L:Y110	R:R:L141	4.69	10	Yes	No	7	5	0	1
L:L:L111	R:R:Y205	12.89	0	No	Yes	8	3	0	1
L:L:E112	R:R:Y205	7.86	0	No	Yes	5	3	0	1
L:L:E112	R:R:R299	4.65	0	No	Yes	5	4	0	1
L:L:Q114	R:R:E138	3.82	10	No	No	6	2	0	1
L:L:K117	R:R:E128	5.4	0	No	No	8	3	0	1
L:L:E118	R:R:W214	7.63	0	No	Yes	7	1	0	1
L:L:F119	R:R:L32	3.65	2	Yes	Yes	9	4	0	1
L:L:F119	R:R:V36	3.93	2	Yes	No	9	2	0	1
L:L:F119	R:R:W214	14.03	2	Yes	Yes	9	1	0	1
L:L:I120	R:R:W91	4.7	0	No	Yes	8	4	0	1
L:L:W122	R:R:W214	17.81	0	No	Yes	4	1	0	1
L:L:L123	R:R:W39	5.69	2	Yes	Yes	9	5	0	1
L:L:L123	R:R:Y88	3.52	2	Yes	Yes	9	5	0	1
L:L:V124	R:R:R121	3.92	0	No	No	7	6	0	1
L:L:V124	R:R:L123	5.96	0	No	No	7	5	0	1
L:L:G126	R:R:E68	8.19	0	No	No	7	4	0	1
L:L:R127	R:R:W39	13	2	Yes	Yes	4	5	0	1
L:L:R127	R:R:E68	18.61	2	Yes	No	4	4	0	1
R:R:L32	R:R:Q213	3.99	2	Yes	No	4	4	1	2
R:R:L32	R:R:W214	4.56	2	Yes	Yes	4	1	1	1
R:R:P90	R:R:T35	5.25	0	Yes	No	4	5	1	2
R:R:R43	R:R:W39	12	2	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	9.65	2	Yes	Yes	5	5	1	1
R:R:Y42	R:R:Y88	9.93	0	No	Yes	6	5	2	1
R:R:D67	R:R:R121	5.96	3	No	No	9	6	2	1
R:R:E68	R:R:L118	3.98	0	No	No	4	4	1	2
R:R:P86	R:R:Y69	6.95	2	Yes	No	8	6	2	2
R:R:L89	R:R:Y69	5.86	2	Yes	No	5	6	2	2
R:R:L123	R:R:Y69	9.38	0	No	No	5	6	1	2
R:R:P86	R:R:Y88	5.56	2	Yes	Yes	8	5	2	1
R:R:L89	R:R:P86	4.93	2	Yes	Yes	5	8	2	2
R:R:L89	R:R:Y88	3.52	2	Yes	Yes	5	5	2	1
R:R:L89	R:R:W91	13.67	2	Yes	Yes	5	4	2	1
R:R:P90	R:R:W91	5.4	0	Yes	Yes	4	4	1	1
R:R:V95	R:R:W91	3.68	0	No	Yes	5	4	2	1
R:R:E128	R:R:W91	14.17	0	No	Yes	3	4	1	1
R:R:L118	R:R:R121	3.64	0	No	No	4	6	2	1
R:R:C126	R:R:L123	3.17	0	No	No	9	5	2	1
R:R:E127	R:R:E128	3.81	0	No	No	2	3	2	1
R:R:P137	R:R:Q140	3.16	0	No	Yes	3	4	1	2
R:R:L141	R:R:Q140	11.98	0	No	Yes	5	4	1	2
R:R:L144	R:R:Q140	3.99	1	No	Yes	6	4	1	2
R:R:L144	R:R:L388	4.15	1	No	No	6	7	1	1
R:R:Y148	R:R:Y152	4.96	1	Yes	Yes	7	7	2	1
R:R:V194	R:R:Y148	6.31	1	No	Yes	7	7	2	2
R:R:K197	R:R:Y148	4.78	1	Yes	Yes	6	7	1	2
R:R:D198	R:R:Y148	10.34	1	No	Yes	7	7	2	2
R:R:L388	R:R:Y148	7.03	1	No	Yes	7	7	1	2
R:R:R190	R:R:Y152	8.23	1	Yes	Yes	8	7	1	1
R:R:A191	R:R:Y152	4	0	No	Yes	7	7	2	1
R:R:V194	R:R:Y152	11.36	1	No	Yes	7	7	2	1
R:R:S392	R:R:Y152	7.63	1	No	Yes	9	7	2	1
R:R:R190	R:R:V237	13.08	1	Yes	No	8	6	1	1
R:R:N240	R:R:R190	9.64	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y241	13.38	1	Yes	Yes	8	8	1	1
R:R:R190	R:R:T391	5.17	1	Yes	No	8	6	1	2
R:R:M233	R:R:S193	4.6	1	Yes	No	6	6	1	2
R:R:D198	R:R:K197	5.53	1	No	Yes	7	6	2	1
R:R:K197	R:R:L201	4.23	1	Yes	No	6	7	1	2
R:R:F230	R:R:K197	3.72	1	No	Yes	5	6	2	1
R:R:K197	R:R:M233	7.2	1	Yes	Yes	6	6	1	1
R:R:F230	R:R:L201	4.87	1	No	No	5	7	2	2
R:R:M204	R:R:Y205	5.99	0	No	Yes	3	3	2	1
R:R:Q210	R:R:W214	8.76	0	No	Yes	4	1	2	1
R:R:Q211	R:R:W214	3.29	0	No	Yes	4	1	2	1
R:R:F230	R:R:T298	15.56	1	No	No	5	5	2	1
R:R:M233	R:R:Q234	9.52	1	Yes	No	6	7	1	1
R:R:V237	R:R:Y241	3.79	1	No	Yes	6	8	1	1
R:R:I313	R:R:Y241	12.09	0	No	Yes	7	8	2	1
R:R:E364	R:R:Y241	4.49	0	No	Yes	8	8	2	1
R:R:M303	R:R:N300	4.21	0	No	No	5	6	2	1
R:R:N300	R:R:W306	14.69	0	No	Yes	6	6	1	1
R:R:R310	R:R:W306	10	1	Yes	Yes	6	6	1	1
R:R:D372	R:R:W306	3.35	0	No	Yes	5	6	1	1
R:R:I313	R:R:R310	10.02	0	No	Yes	7	6	2	1
R:R:L314	R:R:R310	8.5	0	No	Yes	4	6	2	1
R:R:E364	R:R:E387	10.15	0	No	No	8	8	2	1
R:R:R376	R:R:R380	4.26	0	No	Yes	5	5	2	1
R:R:L384	R:R:R380	3.64	0	No	Yes	5	5	2	1
R:R:E387	R:R:K383	12.15	0	No	No	8	7	1	2
R:R:G295	R:R:R299	3	0	No	Yes	4	4	2	1
L:L:E112	R:R:S31	2.87	0	No	No	5	4	0	1
R:R:A375	R:R:R380	2.77	0	No	Yes	4	5	2	1
L:L:A116	R:R:P90	1.87	0	No	Yes	7	4	0	1
R:R:P137	R:R:S136	1.78	0	No	No	3	1	1	2
R:R:P90	R:R:V30	1.77	0	Yes	No	4	2	1	2
L:L:A115	R:R:L32	1.58	0	No	Yes	9	4	0	1
R:R:E34	R:R:S31	1.44	0	No	No	4	4	2	1
L:L:S109	R:R:R299	1.32	0	No	Yes	7	4	0	1
R:R:D215	R:R:W214	1.12	0	No	Yes	3	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9E2A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	391
Number of Links	453
Number of Hubs	57
Number of Links mediated by Hubs	223
Number of Communities	11
Number of Nodes involved in Communities	95
Number of Links involved in Communities	130

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	132225
Length Of Smallest Path	3
Average Path Length	19.1372
Length of Longest Path	42
Minimum Path Strength	1.165
Average Path Strength	6.66285
Maximum Path Strength	24.99
Minimum Path Correlation	0.7
Average Path Correlation	0.96214
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	60.4888
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.8917
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • G protein-coupled receptor binding • glucagon receptor binding • hormone activity • identical protein binding • monosaccharide metabolic process • positive regulation of biological process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of cellular process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • response to activity • negative regulation of execution phase of apoptosis • regulation of execution phase of apoptosis • execution phase of apoptosis • behavior • feeding behavior • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • homeostatic process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • cellular response to glucose stimulus • positive regulation of protein secretion • response to hexose • cellular homeostasis • positive regulation of transport • regulation of cellular localization • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • membrane-enclosed lumen • intracellular organelle lumen • endoplasmic reticulum lumen • organelle lumen • endoplasmic reticulum • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • learning or memory • cognition • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein targeting • protein transmembrane transport • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	GLP-1
UniProt	P01275
Sequence	>9E2A_nogp_Chain_L H A E G T F T S D V S S Y L E G Q A A K E F I A W L V K G R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>9E2A_nogp_Chain_R T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F I G V N F L I F V R V I C I V V S K L K A N D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E F T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	9E2A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	3.3	2025-10-29	To be published
	9E2A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		3.3	2025-10-29	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9E2A_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.