psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A4	L:L:Y1	6.67	No	Yes	0	0	0
2	L:L:Y1	R:R:H210	7.62	Yes	Yes	2	0	7
3	L:L:Y1	R:R:T213	8.74	Yes	No	0	0	5
4	L:L:Y1	R:R:W282	6.75	Yes	Yes	2	0	6
5	L:L:Y1	R:R:I289	6.04	Yes	No	0	0	7
6	L:L:A2	R:R:R357	4.15	No	Yes	3	0	6
7	L:L:A2	R:R:E361	4.53	No	Yes	3	0	7
8	L:L:D3	R:R:V179	5.84	No	No	0	0	7
9	L:L:D3	R:R:K182	5.53	No	Yes	0	0	6
10	L:L:I5	R:R:D350	4.2	No	No	0	0	5
11	L:L:I5	R:R:L354	5.71	No	No	0	0	3
12	L:L:I5	R:R:R357	3.76	No	Yes	0	0	6
13	L:L:F6	R:R:F126	8.57	Yes	Yes	0	0	4
14	L:L:F6	R:R:V129	3.93	Yes	No	0	0	6
15	L:L:F6	R:R:Y133	8.25	Yes	No	0	0	7
16	L:L:F6	R:R:L362	4.87	Yes	No	0	0	7
17	L:L:T7	R:R:K182	9.01	No	Yes	0	0	6
18	L:L:N8	R:R:D274	4.04	No	No	0	0	6
19	L:L:N8	R:R:D276	12.12	No	No	0	0	6
20	L:L:L14	L:L:Y10	12.89	No	Yes	0	0	0
21	L:L:Y10	R:R:F126	5.16	Yes	Yes	0	0	4
22	L:L:Y10	R:R:F187	14.44	Yes	No	0	0	4
23	L:L:R11	R:R:H194	11.28	No	No	0	0	4
24	L:L:R11	R:R:D274	11.91	No	No	0	0	6
25	L:L:V13	R:R:E122	7.13	No	No	0	0	4
26	L:L:L14	R:R:H194	9	No	No	0	0	4
27	L:L:Q16	L:L:R20	7.01	No	No	0	0	0
28	L:L:Q16	R:R:L119	5.32	No	No	0	0	2
29	L:L:L17	R:R:L119	8.3	No	No	0	0	2
30	L:L:K21	L:L:Q24	9.49	No	No	0	0	0
31	R:R:E122	R:R:L119	5.3	No	No	0	4	2
32	R:R:F126	R:R:Y125	10.32	Yes	No	0	4	4
33	R:R:V129	R:R:Y125	5.05	No	No	0	6	4
34	R:R:K130	R:R:Y133	4.78	No	No	0	5	7
35	R:R:D183	R:R:K130	4.15	No	No	0	7	5
36	R:R:V179	R:R:Y133	3.79	No	No	0	7	7
37	R:R:F180	R:R:T134	3.89	Yes	No	0	7	6
38	R:R:G136	R:R:S366	3.71	No	No	0	8	9
39	R:R:F367	R:R:G136	4.52	No	No	0	7	8
40	R:R:A176	R:R:H137	4.39	No	Yes	0	8	7
41	R:R:H137	R:R:V179	4.15	Yes	No	0	7	7
42	R:R:F180	R:R:S138	5.28	Yes	No	0	7	6
43	R:R:F370	R:R:I139	7.54	No	No	0	4	5
44	R:R:G369	R:R:S140	3.71	No	No	0	9	9
45	R:R:F169	R:R:L144	4.87	Yes	Yes	0	8	9
46	R:R:F172	R:R:L144	3.65	Yes	Yes	1	8	9
47	R:R:I173	R:R:L144	5.71	No	Yes	0	7	9
48	R:R:G369	R:R:L144	5.13	No	Yes	1	9	9
49	R:R:F145	R:R:I173	6.28	No	No	0	3	7
50	R:R:F378	R:R:V146	3.93	No	No	0	8	5
51	R:R:A147	R:R:C377	3.61	No	No	0	8	9
52	R:R:F169	R:R:I148	5.02	Yes	No	0	8	5
53	R:R:C377	R:R:I150	4.91	No	No	0	9	8
54	R:R:L151	R:R:N162	5.49	No	No	0	8	8
55	R:R:L151	R:R:T166	4.42	No	No	0	8	6
56	R:R:L154	R:R:L157	4.15	No	Yes	4	7	8
57	R:R:E386	R:R:L154	9.28	No	No	4	8	7
58	R:R:E386	R:R:R156	4.65	No	No	0	8	7
59	R:R:E382	R:R:L157	3.98	No	Yes	0	9	8
60	R:R:E386	R:R:L157	6.63	No	Yes	4	8	8
61	R:R:H158	R:R:Y163	9.8	No	No	0	7	6
62	R:R:C159	R:R:N162	4.72	No	No	0	8	8
63	R:R:N162	R:R:R161	6.03	No	No	0	8	9
64	R:R:H165	R:R:R161	6.77	No	No	0	9	9
65	R:R:E382	R:R:R161	4.65	No	No	0	9	9
66	R:R:F242	R:R:Y163	6.19	Yes	No	0	6	6
67	R:R:V164	R:R:W219	3.68	No	Yes	0	8	9
68	R:R:E223	R:R:V164	8.56	Yes	No	0	9	8
69	R:R:V164	R:R:Y226	3.79	No	Yes	0	8	8
70	R:R:E223	R:R:H165	8.62	Yes	No	0	9	9
71	R:R:H165	R:R:Y376	7.62	No	No	0	9	8
72	R:R:Q167	R:R:W219	21.9	No	Yes	1	9	9
73	R:R:Q167	R:R:V246	10.03	No	No	0	9	5
74	R:R:Q167	R:R:W250	8.76	No	Yes	1	9	9
75	R:R:L168	R:R:T171	4.42	Yes	Yes	0	9	8
76	R:R:F172	R:R:L168	7.31	Yes	Yes	0	8	9
77	R:R:L168	R:R:L220	4.15	Yes	No	0	9	9
78	R:R:E223	R:R:L168	6.63	Yes	Yes	0	9	9
79	R:R:F169	R:R:V372	3.93	Yes	No	0	8	8
80	R:R:T171	R:R:T215	4.71	Yes	No	1	8	8
81	R:R:N216	R:R:T171	4.39	No	Yes	1	8	8
82	R:R:T171	R:R:W219	6.06	Yes	Yes	1	8	9
83	R:R:T171	R:R:W250	3.64	Yes	Yes	1	8	9
84	R:R:F172	R:R:K175	3.72	Yes	No	1	8	8
85	R:R:F172	R:R:N216	14.5	Yes	No	1	8	8
86	R:R:F172	R:R:Q368	9.37	Yes	No	0	8	9
87	R:R:F172	R:R:G369	9.03	Yes	No	1	8	9
88	R:R:K175	R:R:N216	6.99	No	No	1	8	8
89	R:R:L181	R:R:S205	4.5	No	No	0	5	5
90	R:R:K182	R:R:S209	4.59	Yes	No	0	6	6
91	R:R:F187	R:R:L186	4.87	No	No	0	4	6
92	R:R:D191	R:R:T192	4.34	No	No	0	3	4
93	R:R:H194	R:R:T192	5.48	No	No	0	4	4
94	R:R:F197	R:R:T192	9.08	No	No	0	2	4
95	R:R:C272	R:R:F197	4.19	No	No	0	9	2
96	R:R:C202	R:R:C272	7.28	No	No	0	9	9
97	R:R:K203	R:R:W273	31.33	No	Yes	0	7	9
98	R:R:H210	R:R:V206	5.54	Yes	No	0	7	5
99	R:R:H210	R:R:S209	4.18	Yes	No	0	7	6
100	R:R:H210	R:R:W260	10.58	Yes	No	2	7	8
101	R:R:H210	R:R:W282	5.29	Yes	Yes	2	7	6
102	R:R:H210	R:R:I285	5.3	Yes	No	2	7	7
103	R:R:F211	R:R:T215	6.49	No	No	0	8	8
104	R:R:F211	R:R:V254	5.24	No	No	0	8	3
105	R:R:F211	R:R:T257	7.78	No	No	0	8	6
106	R:R:F256	R:R:M214	4.98	No	No	0	5	5
107	R:R:I285	R:R:M214	5.83	No	No	0	7	5
108	R:R:T215	R:R:W250	3.64	No	Yes	1	8	9
109	R:R:F217	R:R:I289	13.82	No	No	0	8	7
110	R:R:F217	R:R:S292	3.96	No	No	0	8	7
111	R:R:F217	R:R:Y342	11.35	No	No	0	8	8
112	R:R:S218	R:R:W219	4.94	No	Yes	0	6	9
113	R:R:G249	R:R:S218	3.71	No	No	0	9	6
114	R:R:P253	R:R:S218	7.13	No	No	0	9	6
115	R:R:A222	R:R:W219	3.89	No	Yes	0	8	9
116	R:R:W219	R:R:W250	17.81	Yes	Yes	1	9	9
117	R:R:L221	R:R:V295	4.47	No	No	0	7	6
118	R:R:A222	R:R:L245	4.73	No	No	0	8	7
119	R:R:E223	R:R:L337	10.6	Yes	No	0	9	9
120	R:R:A224	R:R:L299	4.73	No	No	0	8	8
121	R:R:A224	R:R:F338	6.93	No	Yes	0	8	8
122	R:R:L230	R:R:Y226	8.21	No	Yes	0	7	8
123	R:R:L245	R:R:Y226	3.52	No	Yes	0	7	8
124	R:R:I303	R:R:L227	5.71	No	No	0	8	9
125	R:R:L299	R:R:N228	9.61	No	No	0	8	8
126	R:R:N228	R:R:N302	5.45	No	No	0	8	7
127	R:R:I303	R:R:N228	7.08	No	No	0	8	8
128	R:R:A241	R:R:C229	3.61	No	No	0	4	6
129	R:R:I306	R:R:L231	5.71	No	No	0	7	8
130	R:R:P236	R:R:S235	3.56	No	No	0	5	7
131	R:R:S237	R:R:S238	6.52	No	No	0	6	6
132	R:R:F242	R:R:W243	13.03	Yes	No	0	6	2
133	R:R:F242	R:R:V246	7.87	Yes	No	0	6	5
134	R:R:F256	R:R:L252	3.65	No	No	0	5	3
135	R:R:F256	R:R:P288	11.56	No	No	0	5	8
136	R:R:K264	R:R:W260	10.44	No	No	0	7	8
137	R:R:I285	R:R:W260	12.92	No	No	2	7	8
138	R:R:L265	R:R:W273	4.56	No	Yes	0	3	9
139	R:R:E268	R:R:F267	5.83	No	No	0	5	3
140	R:R:F267	R:R:Y281	15.47	No	No	0	3	3
141	R:R:D269	R:R:W273	8.93	No	Yes	0	5	9
142	R:R:D274	R:R:L275	8.14	No	No	0	6	4
143	R:R:D276	R:R:W282	25.68	No	Yes	0	6	6
144	R:R:P280	R:R:S279	5.34	No	No	0	2	4
145	R:R:P280	R:R:Y281	12.52	No	No	0	2	3
146	R:R:K286	R:R:W282	9.28	Yes	Yes	0	6	6
147	R:R:K286	R:R:W283	12.76	Yes	No	0	6	8
148	R:R:D350	R:R:K286	6.91	No	Yes	0	5	6
149	R:R:G287	R:R:P288	4.06	No	No	0	4	8
150	R:R:N346	R:R:V290	13.3	No	No	0	5	4
151	R:R:N346	R:R:V293	13.3	No	No	0	5	7
152	R:R:F338	R:R:N296	7.25	Yes	No	0	8	9
153	R:R:F297	R:R:L301	8.53	No	No	0	5	5
154	R:R:F297	R:R:I343	12.56	No	No	0	5	5
155	R:R:F300	R:R:L334	4.87	No	No	0	8	9
156	R:R:F300	R:R:I340	11.3	No	No	0	8	6
157	R:R:N302	R:R:R305	9.64	No	No	5	7	7
158	R:R:I306	R:R:N302	5.66	No	No	5	7	7
159	R:R:I304	R:R:T331	6.08	No	No	0	6	8
160	R:R:I306	R:R:R305	6.26	No	No	5	7	7
161	R:R:R305	R:R:R309	4.26	No	No	0	7	6
162	R:R:T320	R:R:Y324	3.75	No	No	0	6	6
163	R:R:S328	R:R:W325	3.71	No	No	0	7	6
164	R:R:K329	R:R:R326	9.9	No	No	0	8	7
165	R:R:R326	R:R:S330	7.91	No	No	0	7	8
166	R:R:F333	R:R:K329	4.96	No	No	0	8	8
167	R:R:F333	R:R:L375	7.31	No	No	0	8	7
168	R:R:F338	R:R:L334	7.31	Yes	No	0	8	9
169	R:R:I335	R:R:P336	6.77	No	No	0	8	9
170	R:R:I335	R:R:I340	4.42	No	No	0	8	6
171	R:R:F338	R:R:L337	7.31	Yes	No	0	8	9
172	R:R:L337	R:R:Y376	19.93	No	No	0	9	8
173	R:R:H341	R:R:Y342	14.16	Yes	No	0	8	8
174	R:R:H341	R:R:Q368	4.95	Yes	No	0	8	9
175	R:R:E361	R:R:Y342	8.98	Yes	No	0	7	8
176	R:R:F345	R:R:I344	7.54	Yes	No	0	6	6
177	R:R:F345	R:R:L348	4.87	Yes	No	0	6	5
178	R:R:F345	R:R:I356	5.02	Yes	No	0	6	5
179	R:R:F345	R:R:R357	18.17	Yes	Yes	3	6	6
180	R:R:F345	R:R:L360	3.65	Yes	No	0	6	4
181	R:R:E361	R:R:F345	5.83	Yes	Yes	3	7	6
182	R:R:F347	R:R:N346	14.5	No	No	0	5	5
183	R:R:L348	R:R:P349	4.93	No	No	0	5	6
184	R:R:N351	R:R:P349	8.15	No	No	0	4	6
185	R:R:A352	R:R:N351	6.25	No	No	0	3	4
186	R:R:L354	R:R:L358	6.92	No	No	0	3	6
187	R:R:E361	R:R:R357	9.3	Yes	Yes	3	7	6
188	R:R:F370	R:R:I374	11.3	No	No	0	4	5
189	R:R:F378	R:R:I374	3.77	No	No	0	8	5
190	R:R:L375	R:R:Y376	3.52	No	No	0	7	8
191	R:R:C377	R:R:F378	5.59	No	No	0	9	8
192	R:R:E382	R:R:N380	14.46	No	No	0	9	9
193	R:R:Q381	R:R:R384	8.18	No	No	0	5	7
194	R:R:H392	R:R:W391	9.52	No	No	0	4	5
195	R:R:K264	R:R:W273	3.48	No	Yes	0	7	9
196	R:R:A185	R:R:S205	3.42	No	No	0	3	5
197	R:R:F180	R:R:H137	3.39	Yes	Yes	0	7	7
198	R:R:I371	R:R:P336	3.39	No	No	0	5	9
199	R:R:C202	R:R:T199	3.38	No	No	0	9	3
200	R:R:C263	R:R:I284	3.27	No	No	0	4	7
201	R:R:S235	R:R:S237	3.26	No	No	0	7	6
202	R:R:A176	R:R:I141	3.25	No	No	0	8	7
203	R:R:G339	R:R:H341	3.18	No	Yes	0	9	8
204	R:R:A185	R:R:L201	3.15	No	No	0	3	4
205	R:R:C195	R:R:D193	3.11	No	No	0	4	2
206	R:R:R239	R:R:Y226	3.09	No	Yes	0	5	8
207	R:R:K182	R:R:S205	3.06	Yes	No	0	6	5
208	R:R:K203	R:R:S198	3.06	No	No	0	7	6
209	R:R:K286	R:R:V290	3.04	Yes	No	0	6	4
210	R:R:F180	R:R:G177	3.01	Yes	No	0	7	3
211	R:R:F345	R:R:G353	3.01	Yes	No	0	6	3
212	R:R:L221	R:R:S292	3	No	No	0	7	7
213	R:R:L307	R:R:S330	3	No	No	0	8	8
214	R:R:L157	R:R:V383	2.98	Yes	No	0	8	9
215	R:R:L221	R:R:V225	2.98	No	Yes	0	7	6
216	R:R:L245	R:R:V225	2.98	No	Yes	0	7	6
217	R:R:L299	R:R:V225	2.98	No	Yes	0	8	6
218	R:R:L265	R:R:V261	2.98	No	No	0	3	5
219	R:R:L327	R:R:T331	2.95	No	No	0	8	8
220	L:L:I26	L:L:M27	2.92	No	No	0	0	0
221	R:R:F242	R:R:P160	2.89	Yes	No	0	6	7
222	R:R:K390	R:R:L154	2.82	No	No	0	4	7
223	R:R:H137	R:R:S366	2.79	Yes	No	0	7	9
224	R:R:H392	R:R:S388	2.79	No	No	0	4	5
225	R:R:A143	R:R:F370	2.77	No	No	0	6	4
226	R:R:A147	R:R:F169	2.77	No	Yes	0	8	8
227	R:R:A266	R:R:F267	2.77	No	No	0	3	3
228	R:R:E268	R:R:I270	2.73	No	No	0	5	4
229	L:L:L22	R:R:D193	2.71	No	No	0	0	2
230	R:R:E268	R:R:K264	2.7	No	No	0	5	7
231	R:R:C263	R:R:Y281	2.69	No	No	0	4	3
232	L:L:L17	R:R:E123	2.65	No	No	0	0	2
233	L:L:S9	R:R:F126	2.64	No	Yes	0	0	4
234	R:R:R240	R:R:S238	2.64	No	No	0	5	6
235	L:L:V13	R:R:F126	2.62	No	Yes	0	0	4
236	R:R:F300	R:R:T331	2.59	No	No	0	8	8
237	L:L:Y10	R:R:S127	2.54	Yes	No	0	0	2
238	R:R:F297	R:R:I340	2.51	No	No	0	5	6
239	R:R:F333	R:R:L379	2.44	No	No	0	8	5
240	R:R:T170	R:R:W250	2.43	No	Yes	0	3	9
241	R:R:G251	R:R:P253	2.03	No	No	0	7	9
242	R:R:R240	R:R:W244	2	No	No	0	5	1
243	L:L:G15	R:R:C195	1.96	No	No	0	0	4
244	R:R:A248	R:R:G249	1.95	No	No	0	7	9
245	L:L:G15	L:L:S18	1.86	No	No	0	0	0
246	R:R:G363	R:R:S366	1.86	No	No	0	5	9
247	R:R:G136	R:R:V135	1.84	No	No	0	8	6
248	L:L:A19	R:R:C195	1.81	No	No	0	0	4
249	R:R:A143	R:R:A373	1.79	No	No	0	6	8
250	R:R:A147	R:R:A373	1.79	No	No	0	8	8
251	R:R:A178	R:R:A212	1.79	No	No	0	6	5
252	R:R:G363	R:R:I132	1.76	No	No	0	5	6
253	R:R:G355	R:R:I356	1.76	No	No	0	3	5
254	R:R:P280	R:R:T278	1.75	No	No	0	2	5
255	L:L:G15	L:L:L14	1.71	No	No	0	0	0
256	R:R:A178	R:R:S209	1.71	No	No	0	6	6
257	R:R:C229	R:R:V225	1.71	No	Yes	0	6	6
258	R:R:G298	R:R:L301	1.71	No	No	0	4	5
259	R:R:A207	R:R:V261	1.7	No	No	0	6	5
260	R:R:C263	R:R:T259	1.69	No	No	0	4	5
261	R:R:L358	R:R:P359	1.64	No	No	0	6	7
262	R:R:A271	R:R:I270	1.62	No	No	0	3	4
263	R:R:V200	R:R:V204	1.6	No	No	0	4	3
264	R:R:S233	R:R:T234	1.6	No	No	0	5	7
265	R:R:S235	R:R:T234	1.6	No	No	0	7	7
266	R:R:T149	R:R:V146	1.59	No	No	0	2	5
267	R:R:T166	R:R:V152	1.59	No	No	0	6	3
268	R:R:G365	R:R:H341	1.59	No	Yes	0	7	8
269	R:R:A212	R:R:L174	1.58	No	No	0	5	6
270	R:R:I387	R:R:S388	1.55	No	No	0	5	5
271	R:R:A184	R:R:D183	1.54	No	No	0	3	7
272	R:R:I387	R:R:V383	1.54	No	No	0	5	9
273	R:R:I131	R:R:T134	1.52	No	No	0	4	6
274	R:R:A120	R:R:E121	1.51	No	No	0	4	2
275	R:R:A120	R:R:E123	1.51	No	No	0	4	2
276	R:R:F347	R:R:G294	1.51	No	No	0	5	4
277	R:R:L327	R:R:V308	1.49	No	No	0	8	5
278	L:L:S18	R:R:D190	1.47	No	No	0	0	3
279	R:R:E123	R:R:S124	1.44	No	No	0	2	3
280	R:R:Q321	R:R:S322	1.44	No	No	0	5	5
281	R:R:Q323	R:R:S322	1.44	No	No	0	6	5
282	R:R:Q381	R:R:T385	1.42	No	No	0	5	5
283	L:L:K21	L:L:L17	1.41	No	No	0	0	0
284	R:R:L311	R:R:L327	1.38	No	No	0	7	8
285	R:R:L360	R:R:L364	1.38	No	No	0	4	6
286	R:R:D277	R:R:L275	1.36	No	No	0	3	4
287	L:L:L23	L:L:Q24	1.33	No	No	0	0	0
288	R:R:L311	R:R:Q323	1.33	No	No	0	7	6
289	R:R:R384	R:R:V383	1.31	No	No	0	7	9
290	R:R:D191	R:R:H188	1.26	No	No	0	3	4
291	R:R:R156	R:R:R389	1.07	No	No	0	7	7
292	R:R:R240	R:R:W243	1	No	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	7.164	5	2	0
2	L:L:F6	6.405	4	0	0
3	L:L:Y10	8.7575	4	0	0
4	R:R:F126	5.862	5	0	4
5	R:R:H137	3.68	4	0	7
6	R:R:L144	4.84	4	1	9
7	R:R:L157	4.435	4	4	8
8	R:R:L168	5.6275	4	0	9
9	R:R:F169	4.1475	4	0	8
10	R:R:T171	4.644	5	1	8
11	R:R:F172	7.93	6	1	8
12	R:R:F180	3.8925	4	0	7
13	R:R:K182	5.5475	4	0	6
14	R:R:H210	6.41833	6	2	7
15	R:R:W219	9.71333	6	1	9
16	R:R:E223	8.6025	4	0	9
17	R:R:V225	2.6625	4	0	6
18	R:R:Y226	4.6525	4	0	8
19	R:R:F242	7.495	4	0	6
20	R:R:W250	7.256	5	1	9
21	R:R:W273	12.075	4	0	9
22	R:R:W282	11.75	4	2	6
23	R:R:K286	7.9975	4	0	6
24	R:R:F338	7.2	4	0	8
25	R:R:H341	5.97	4	0	8
26	R:R:F345	6.87	7	3	6
27	R:R:R357	8.845	4	3	6
28	R:R:E361	7.16	4	3	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y1	R:R:H210	70.4077	7.62	Yes	Yes	2	0	7
2	L:L:Y1	R:R:W282	28.4613	6.75	Yes	Yes	2	0	6
3	L:L:Y1	R:R:I289	99.716	6.04	Yes	No	0	0	7
4	R:R:E361	R:R:Y342	29.7292	8.98	Yes	No	0	7	8
5	R:R:F217	R:R:Y342	60.7567	11.35	No	No	0	8	8
6	R:R:F217	R:R:I289	100	13.82	No	No	0	8	7
7	R:R:K286	R:R:W282	21.7162	9.28	Yes	Yes	0	6	6
8	R:R:D350	R:R:K286	15.2551	6.91	No	Yes	0	5	6
9	L:L:I5	R:R:D350	15.5695	4.2	No	No	0	0	5
10	L:L:I5	R:R:R357	17.5981	3.76	No	Yes	0	0	6
11	R:R:H210	R:R:S209	60.3966	4.18	Yes	No	0	7	6
12	R:R:K182	R:R:S209	56.4408	4.59	Yes	No	0	6	6
13	L:L:D3	R:R:K182	50.6897	5.53	No	Yes	0	0	6
14	L:L:D3	R:R:V179	49.7414	5.84	No	No	0	0	7
15	R:R:V179	R:R:Y133	34.6029	3.79	No	No	0	7	7
16	L:L:F6	R:R:Y133	30.2617	8.25	Yes	No	0	0	7
17	L:L:F6	R:R:F126	25.5858	8.57	Yes	Yes	0	0	4
18	R:R:D276	R:R:W282	32.4475	25.68	No	Yes	0	6	6
19	L:L:N8	R:R:D276	31.3926	12.12	No	No	0	0	6
20	L:L:N8	R:R:D274	30.3631	4.04	No	No	0	0	6
21	L:L:R11	R:R:D274	27.5028	11.91	No	No	0	0	6
22	L:L:R11	R:R:H194	26.6102	11.28	No	No	0	0	4
23	L:L:L14	R:R:H194	19.3884	9	No	No	0	0	4
24	L:L:L14	L:L:Y10	11.9282	12.89	No	Yes	0	0	0
25	L:L:V13	R:R:F126	20.991	2.62	No	Yes	0	0	4
26	L:L:V13	R:R:E122	19.5304	7.13	No	No	0	0	4
27	R:R:E122	R:R:L119	17.9582	5.3	No	No	0	4	2
28	L:L:L17	R:R:L119	13.1707	8.3	No	No	0	0	2
29	R:R:H137	R:R:V179	21.0113	4.15	Yes	No	0	7	7
30	R:R:H341	R:R:Y342	71.0518	14.16	Yes	No	0	8	8
31	R:R:H341	R:R:Q368	71.3105	4.95	Yes	No	0	8	9
32	R:R:F172	R:R:Q368	71.4474	9.37	Yes	No	0	8	9
33	R:R:F172	R:R:L144	28.6185	3.65	Yes	Yes	1	8	9
34	R:R:F169	R:R:L144	23.9223	4.87	Yes	Yes	0	8	9
35	R:R:A147	R:R:F169	18.9624	2.77	No	Yes	0	8	8
36	R:R:A147	R:R:C377	10.4067	3.61	No	No	0	8	9
37	R:R:F172	R:R:L168	58.6013	7.31	Yes	Yes	0	8	9
38	R:R:E223	R:R:L168	45.6284	6.63	Yes	Yes	0	9	9
39	R:R:E223	R:R:H165	37.3466	8.62	Yes	No	0	9	9
40	R:R:H165	R:R:R161	31.9302	6.77	No	No	0	9	9
41	R:R:E382	R:R:R161	23.6484	4.65	No	No	0	9	9
42	R:R:E382	R:R:L157	20.8642	3.98	No	Yes	0	9	8
43	R:R:F217	R:R:S292	49.1936	3.96	No	No	0	8	7
44	R:R:L221	R:R:S292	48.8843	3	No	No	0	7	7
45	R:R:L221	R:R:V225	48.3264	2.98	No	Yes	0	7	6
46	R:R:L245	R:R:V225	22.9334	2.98	No	Yes	0	7	6
47	R:R:A222	R:R:L245	18.3994	4.73	No	No	0	8	7
48	R:R:A222	R:R:W219	18.2321	3.89	No	Yes	0	8	9
49	R:R:Q167	R:R:W219	22.8776	21.9	No	Yes	1	9	9
50	R:R:Q167	R:R:V246	28.4359	10.03	No	No	0	9	5
51	R:R:F242	R:R:V246	26.4733	7.87	Yes	No	0	6	5
52	R:R:L299	R:R:V225	29.9422	2.98	No	Yes	0	8	6
53	R:R:A224	R:R:L299	25.9154	4.73	No	No	0	8	8
54	R:R:A224	R:R:F338	25.6669	6.93	No	Yes	0	8	8
55	R:R:F338	R:R:L337	23.8716	7.31	Yes	No	0	8	9
56	R:R:L337	R:R:Y376	18.2625	19.93	No	No	0	9	8
57	R:R:E223	R:R:L337	23.1971	10.6	Yes	No	0	9	9
58	R:R:H165	R:R:Y376	12.9831	7.62	No	No	0	9	8
59	R:R:L168	R:R:T171	17.5931	4.42	Yes	Yes	0	9	8
60	R:R:T171	R:R:W250	11.1776	3.64	Yes	Yes	1	8	9
61	R:R:F172	R:R:N216	15.747	14.5	Yes	No	1	8	8
62	R:R:N216	R:R:T171	15.5239	4.39	No	Yes	1	8	8
63	R:R:H194	R:R:T192	10.4676	5.48	No	No	0	4	4
64	R:R:H210	R:R:W260	30.2414	10.58	Yes	No	2	7	8
65	R:R:K264	R:R:W260	29.5111	10.44	No	No	0	7	8
66	R:R:K264	R:R:W273	10.7871	3.48	No	Yes	0	7	9
67	R:R:L299	R:R:N228	11.7101	9.61	No	No	0	8	8
68	R:R:F242	R:R:W243	18.5262	13.03	Yes	No	0	6	2
69	R:R:R240	R:R:W243	16.5078	1	No	No	0	5	2
70	R:R:R240	R:R:S238	12.4404	2.64	No	No	0	5	6
71	R:R:S237	R:R:S238	10.3915	6.52	No	No	0	6	6
72	R:R:E268	R:R:K264	18.1915	2.7	No	No	0	5	7
73	R:R:E268	R:R:F267	13.7793	5.83	No	No	0	5	3
74	R:R:F267	R:R:Y281	10.7871	15.47	No	No	0	3	3
75	R:R:F338	R:R:L334	27.0971	7.31	Yes	No	0	8	9
76	R:R:F300	R:R:L334	25.6669	4.87	No	No	0	8	9
77	R:R:F300	R:R:I340	12.5165	11.3	No	No	0	8	6
78	R:R:F300	R:R:T331	12.3086	2.59	No	No	0	8	8
79	R:R:L375	R:R:Y376	21.1786	3.52	No	No	0	7	8
80	R:R:F333	R:R:L375	18.1509	7.31	No	No	0	8	7
81	R:R:F333	R:R:K329	12.1564	4.96	No	No	0	8	8
82	R:R:E361	R:R:F345	16.9541	5.83	Yes	Yes	3	7	6
83	R:R:L157	R:R:V383	12.1767	2.98	Yes	No	0	8	9
84	L:L:G15	L:L:L14	10.3915	1.71	No	No	0	0	0
85	R:R:H210	R:R:W282	15.5746	5.29	Yes	Yes	2	7	6
86	R:R:T171	R:R:W219	11.8927	6.06	Yes	Yes	1	8	9
87	R:R:E223	R:R:V164	10.7871	8.56	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:H210	7.62	2	Yes	Yes	0	7	0	1
L:L:Y1	R:R:T213	8.74	2	Yes	No	0	5	0	1
L:L:Y1	R:R:W282	6.75	2	Yes	Yes	0	6	0	1
L:L:Y1	R:R:I289	6.04	2	Yes	No	0	7	0	1
L:L:A2	R:R:R357	4.15	3	No	Yes	0	6	0	1
L:L:A2	R:R:E361	4.53	3	No	Yes	0	7	0	1
L:L:D3	R:R:V179	5.84	0	No	No	0	7	0	1
L:L:D3	R:R:K182	5.53	0	No	Yes	0	6	0	1
L:L:I5	R:R:D350	4.2	0	No	No	0	5	0	1
L:L:I5	R:R:L354	5.71	0	No	No	0	3	0	1
L:L:I5	R:R:R357	3.76	0	No	Yes	0	6	0	1
L:L:F6	R:R:F126	8.57	0	Yes	Yes	0	4	0	1
L:L:F6	R:R:V129	3.93	0	Yes	No	0	6	0	1
L:L:F6	R:R:Y133	8.25	0	Yes	No	0	7	0	1
L:L:F6	R:R:L362	4.87	0	Yes	No	0	7	0	1
L:L:T7	R:R:K182	9.01	0	No	Yes	0	6	0	1
L:L:N8	R:R:D274	4.04	0	No	No	0	6	0	1
L:L:N8	R:R:D276	12.12	0	No	No	0	6	0	1
L:L:Y10	R:R:F126	5.16	0	Yes	Yes	0	4	0	1
L:L:Y10	R:R:F187	14.44	0	Yes	No	0	4	0	1
L:L:R11	R:R:H194	11.28	0	No	No	0	4	0	1
L:L:R11	R:R:D274	11.91	0	No	No	0	6	0	1
L:L:V13	R:R:E122	7.13	0	No	No	0	4	0	1
L:L:L14	R:R:H194	9	0	No	No	0	4	0	1
L:L:Q16	R:R:L119	5.32	0	No	No	0	2	0	1
L:L:L17	R:R:L119	8.3	0	No	No	0	2	0	1
R:R:E122	R:R:L119	5.3	0	No	No	4	2	1	1
R:R:F126	R:R:Y125	10.32	0	Yes	No	4	4	1	2
R:R:V129	R:R:Y125	5.05	0	No	No	6	4	1	2
R:R:K130	R:R:Y133	4.78	0	No	No	5	7	2	1
R:R:V179	R:R:Y133	3.79	0	No	No	7	7	1	1
R:R:H137	R:R:V179	4.15	0	Yes	No	7	7	2	1
R:R:K182	R:R:S209	4.59	0	Yes	No	6	6	1	2
R:R:F187	R:R:L186	4.87	0	No	No	4	6	1	2
R:R:H194	R:R:T192	5.48	0	No	No	4	4	1	2
R:R:H210	R:R:V206	5.54	2	Yes	No	7	5	1	2
R:R:H210	R:R:S209	4.18	2	Yes	No	7	6	1	2
R:R:H210	R:R:W260	10.58	2	Yes	No	7	8	1	2
R:R:H210	R:R:W282	5.29	2	Yes	Yes	7	6	1	1
R:R:H210	R:R:I285	5.3	2	Yes	No	7	7	1	2
R:R:F217	R:R:I289	13.82	0	No	No	8	7	2	1
R:R:F217	R:R:Y342	11.35	0	No	No	8	8	2	2
R:R:I285	R:R:W260	12.92	2	No	No	7	8	2	2
R:R:D274	R:R:L275	8.14	0	No	No	6	4	1	2
R:R:D276	R:R:W282	25.68	0	No	Yes	6	6	1	1
R:R:K286	R:R:W282	9.28	0	Yes	Yes	6	6	2	1
R:R:D350	R:R:K286	6.91	0	No	Yes	5	6	1	2
R:R:E361	R:R:Y342	8.98	3	Yes	No	7	8	1	2
R:R:F345	R:R:R357	18.17	3	Yes	Yes	6	6	2	1
R:R:E361	R:R:F345	5.83	3	Yes	Yes	7	6	1	2
R:R:L354	R:R:L358	6.92	0	No	No	3	6	1	2
R:R:E361	R:R:R357	9.3	3	Yes	Yes	7	6	1	1
R:R:C195	R:R:D193	3.11	0	No	No	4	2	1	1
R:R:K182	R:R:S205	3.06	0	Yes	No	6	5	1	2
L:L:L22	R:R:D193	2.71	0	No	No	0	2	0	1
L:L:L17	R:R:E123	2.65	0	No	No	0	2	0	1
L:L:S9	R:R:F126	2.64	0	No	Yes	0	4	0	1
L:L:V13	R:R:F126	2.62	0	No	Yes	0	4	0	1
L:L:Y10	R:R:S127	2.54	0	Yes	No	0	2	0	1
L:L:G15	R:R:C195	1.96	0	No	No	0	4	0	1
L:L:A19	R:R:C195	1.81	0	No	No	0	4	0	1
R:R:A120	R:R:E123	1.51	0	No	No	4	2	2	1
L:L:S18	R:R:D190	1.47	0	No	No	0	3	0	1
R:R:E123	R:R:S124	1.44	0	No	No	2	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7CZ5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	276
Number of Links	292
Number of Hubs	28
Number of Links mediated by Hubs	107
Number of Communities	5
Number of Nodes involved in Communities	25
Number of Links involved in Communities	31

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	45937
Length Of Smallest Path	3
Average Path Length	14.3485
Length of Longest Path	34
Minimum Path Strength	1.38333
Average Path Strength	6.94813
Maximum Path Strength	20.13
Minimum Path Correlation	0.7
Average Path Correlation	0.93983
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	56.9217
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.1343
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to hormone • response to endogenous stimulus • response to chemical • response to estrogen • cellular response to stimulus • homeostatic process • response to oxygen-containing compound • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • cellular process • regulation of hormone levels • biological regulation • metabolic process • regulation of biological quality • hormone metabolic process • multicellular organismal process • regulation of circadian sleep/wake cycle • positive regulation of biological process • regulation of circadian sleep/wake cycle, non-REM sleep • regulation of circadian rhythm • regulation of behavior • circadian sleep/wake cycle, non-REM sleep • regulation of multicellular organismal process • sleep • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • regulation of biological process • rhythmic behavior • positive regulation of circadian sleep/wake cycle, non-REM sleep • circadian rhythm • behavior • circadian behavior • positive regulation of behavior • positive regulation of circadian rhythm • positive regulation of multicellular organismal process • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • reproductive process • multicellular organismal reproductive process • response to corticosteroid • response to lipid • response to steroid hormone • response to glucocorticoid • developmental process • cellular developmental process • anatomical structure maturation • cell differentiation • anatomical structure development • cell development • cell maturation • developmental maturation • localization • cellular localization • establishment of localization in cell • establishment of localization • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cellular process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of response to stimulus • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of insulin-like growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • regulation of signaling • cell surface receptor signaling pathway • insulin-like growth factor receptor signaling pathway • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • determination of adult lifespan • intracellular signal transduction • cAMP/PKA signal transduction • intracellular signaling cassette • response to peptide hormone • response to insulin • response to nitrogen compound • regulation of body fluid levels • secretion • transport • mammary gland development • gland development • animal organ development • body fluid secretion • lactation • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of developmental growth • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • cellular response to endogenous stimulus • cellular response to insulin stimulus • cellular response to hormone stimulus • nitrogen compound transport • hormone secretion • peptide secretion • secretion by cell • amide transport • signal release • growth hormone secretion • cell-cell signaling • export from cell • peptide transport • peptide hormone secretion • hormone transport • head development • somatotropin secreting cell differentiation • forebrain development • endocrine system development • pituitary gland development • brain development • diencephalon development • nervous system development • multicellular organism development • central nervous system development • somatotropin secreting cell development • adenohypophysis development • system development • regulation of localization • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • regulation of peptide hormone secretion • positive regulation of peptide secretion • regulation of transport • regulation of growth hormone secretion • regulation of peptide transport • positive regulation of peptide hormone secretion • regulation of secretion • positive regulation of growth hormone secretion • positive regulation of transport • intracellular receptor signaling pathway • hormone-mediated signaling pathway • regulation of intracellular signal transduction • regulation of intracellular steroid hormone receptor signaling pathway • nuclear receptor-mediated steroid hormone signaling pathway • cellular response to steroid hormone stimulus • steroid hormone receptor signaling pathway • cellular response to lipid • nuclear receptor-mediated signaling pathway • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • nuclear lumen • nuclear matrix • membrane • cell surface
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • nuclear lumen • nuclear matrix • membrane • cell surface • cell periphery • sarcolemma • plasma membrane • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • nuclear outer membrane • nuclear membrane • organelle outer membrane • organelle envelope • bounding membrane of organelle • nuclear outer membrane-endoplasmic reticulum membrane network • nuclear envelope • outer membrane • organelle membrane • organelle inner membrane • nuclear inner membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • hormone activity • growth hormone-releasing hormone activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • growth hormone-releasing hormone receptor binding • neuropeptide receptor binding • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • head development • forebrain development • endocrine system development • pituitary gland development • gland development • brain development • diencephalon development • nervous system development • central nervous system development • adenohypophysis development • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of response to stimulus • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of insulin-like growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • insulin-like growth factor receptor signaling pathway • positive regulation of signaling • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of developmental growth • growth hormone secretion • regulation of circadian sleep/wake cycle • regulation of circadian rhythm • regulation of behavior • sleep • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • circadian rhythm • regulation of circadian sleep/wake cycle, REM sleep • behavior • circadian behavior • circadian sleep/wake cycle, REM sleep • positive regulation of behavior • positive regulation of circadian rhythm • positive regulation of circadian sleep/wake cycle, REM sleep • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • regulation of growth hormone secretion • positive regulation of peptide hormone secretion • positive regulation of growth hormone secretion • positive regulation of transport • response to nutrient levels • response to food • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • synapse • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse • cell projection • distal axon • terminal bouton • cell junction • neuron projection terminus • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • dendrite • dendritic tree • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • G-protein beta-subunit binding
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q02643
Sequence	>7CZ5_nogp_Chain_R L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L R R L H C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F H S D D T D H C S F S T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S T S P S S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E D I A C W D L D D T S P Y W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L E T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L P D N A G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E V R T E I S R K W H G H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	doi.org/10.1073/pnas.2106606118

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