Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:K113 5.17441
2R:R:H127 8.11417
3R:R:R151 4.87408
4R:R:H155 8.92429
5R:R:F162 9.246517
6R:R:R165 5.2225418
7R:R:W169 8.39833617
8R:R:R189 6.88416
9R:R:Y195 6.374515
10R:R:T201 5.7375407
11R:R:F203 8.126518
12R:R:F204 3.675465
13R:R:W205 9.955409
14R:R:M206 5.4725419
15R:R:F207 3.77406
16R:R:E209 9.945429
17R:R:F231 5.1725406
18R:R:P239 4.088569
19R:R:W246 6.965618
20R:R:K250 11.895416
21R:R:W259 10.136519
22R:R:R263 7.635433
23R:R:Y272 9.674517
24R:R:Q273 5.146517
25R:R:L287 4.2375477
26R:R:Q308 3.668505
27R:R:I325 4.2975476
28R:R:Y327 6.054518
29R:R:M328 3.3875404
30R:R:F331 6.32405
31R:R:Y346 4.14406
32R:R:E352 4.3775408
33R:R:F354 6.908556
34R:R:Q355 6.1375419
35R:R:F365 2.945406
36L:L:I7 4.034510
37L:L:D8 5.15410
38L:L:F11 6.422510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:L20 L:L:T23 15.57351.47NoNo000
2L:L:L20 R:R:H117 18.41823.86NoNo402
3L:L:L17 R:R:H117 33.49342.57NoNo002
4L:L:L17 R:R:V120 36.44685.96NoNo004
5R:R:V120 R:R:Y124 39.38212.52NoNo046
6R:R:Q173 R:R:Y124 42.29933.38NoNo076
7R:R:Q173 R:R:W169 48.079414.24NoYes077
8R:R:W169 R:R:Y195 51.57647.72YesYes175
9L:L:F11 R:R:Y195 1004.13YesYes105
10L:L:D8 L:L:F11 39.49088.36YesYes100
11L:L:D8 R:R:Q273 36.46495.22YesYes107
12L:L:L5 R:R:Q273 31.87173.99NoYes107
13L:L:L5 R:R:F331 60.78099.74NoYes005
14L:L:S6 R:R:F331 53.00785.28NoYes005
15L:L:S6 R:R:N348 50.38058.94NoNo008
16R:R:F344 R:R:N348 47.73517.25NoNo068
17R:R:F330 R:R:F344 45.07167.5NoNo076
18R:R:F330 R:R:S340 42.38993.96NoNo072
19R:R:P334 R:R:S340 34.23633.56NoNo052
20R:R:N333 R:R:P334 31.48226.52NoNo065
21R:R:N333 R:R:R341 28.70994.82NoNo064
22R:R:R341 R:R:Y116 23.11113.09NoNo043
23R:R:S112 R:R:Y116 20.284513.99NoNo023
24R:R:H115 R:R:S112 17.43985.58NoNo042
25L:L:T10 R:R:W169 22.06927.28NoYes107
26L:L:T10 R:R:E352 56.15154.23NoYes008
27R:R:E352 R:R:Y327 30.23194.49YesYes088
28L:L:I7 R:R:Y327 58.84223.63YesYes108
29L:L:I7 L:L:L5 31.4554.28YesNo100
30R:R:H115 R:R:Y346 11.6967.62NoYes046
31R:R:H127 R:R:W169 44.518913.75YesYes177
32R:R:H127 R:R:S353 41.40249.76YesNo078
33R:R:F354 R:R:S353 39.01075.28YesNo068
34R:R:H127 R:R:N166 20.80995.1YesNo077
35R:R:F354 R:R:F358 26.45414.29YesNo066
36R:R:F357 R:R:F358 22.63094.29NoNo056
37R:R:F357 R:R:V361 20.84626.55NoNo055
38R:R:F365 R:R:V361 19.88583.93YesNo065
39R:R:C364 R:R:F365 19.54162.79NoYes086
40R:R:C364 R:R:F141 21.49852.79NoNo087
41R:R:F141 R:R:W156 34.571516.04NoNo075
42R:R:F138 R:R:W156 25.357910.02NoNo065
43R:R:F138 R:R:I163 22.25043.77NoNo067
44R:R:I163 R:R:L134 12.81944.28NoNo078
45R:R:N166 R:R:R165 20.28453.62NoYes078
46R:R:F162 R:R:R165 45.72395.34YesYes178
47R:R:F162 R:R:L158 93.09666.09YesNo078
48R:R:E209 R:R:L158 92.54393.98YesNo098
49R:R:E209 R:R:H155 76.879919.69YesYes299
50R:R:H155 R:R:R151 66.95964.51YesYes098
51R:R:N152 R:R:R151 51.12348.44NoYes088
52R:R:E352 R:R:R165 40.4243.49YesYes088
53R:R:N367 R:R:R151 30.02362.41NoYes098
54R:R:N367 R:R:V370 21.21765.91NoNo099
55R:R:L144 R:R:V370 18.22791.49NoNo069
56R:R:E209 R:R:I154 49.29346.83YesNo098
57R:R:F231 R:R:I154 42.99695.02YesNo068
58R:R:F231 R:R:Y212 32.80494.13YesNo067
59R:R:L150 R:R:Y212 21.59815.86NoNo067
60R:R:R151 R:R:Y212 30.41314.12YesNo087
61R:R:K228 R:R:L150 13.00962.82NoNo056
62R:R:T168 R:R:Y195 74.93214.99NoYes045
63R:R:F198 R:R:T168 73.53695.19NoNo064
64R:R:F198 R:R:Y197 72.83024.13NoNo068
65R:R:T201 R:R:Y197 72.52228.74YesNo078
66R:R:T201 R:R:W236 54.93757.28YesNo079
67R:R:W205 R:R:W236 54.729113.12YesNo099
68R:R:E209 R:R:L322 12.84659.28YesNo298
69R:R:H155 R:R:Y363 12.83757.62YesNo298
70R:R:L322 R:R:Y363 10.726615.24NoNo288
71R:R:Q355 R:R:Y327 43.631110.15YesYes198
72L:L:F11 R:R:F260 59.34958.57YesNo106
73R:R:F260 R:R:H181 57.2935.66NoNo064
74L:L:L18 R:R:H181 33.55685.14NoNo004
75L:L:L18 R:R:P178 31.08353.28NoNo002
76R:R:P178 R:R:S177 26.08263.56NoNo024
77R:R:S177 R:R:V180 21.00923.23NoNo042
78R:R:V180 R:R:W187 10.6457.36NoNo022
79R:R:H181 R:R:K257 23.55513.1NoNo043
80L:L:F11 R:R:N196 28.99088.46YesNo108
81R:R:N196 R:R:W246 24.81436.78NoYes188
82R:R:W246 R:R:W259 27.82214.69YesYes189
83R:R:N255 R:R:W259 16.669710.17NoYes149
84R:R:P239 R:R:T201 99.2395.25YesYes097
85R:R:F204 R:R:P239 91.05824.33YesYes659
86R:R:F204 R:R:V279 83.2852.62YesNo057
87R:R:F207 R:R:V279 81.21043.93YesNo067
88R:R:F207 R:R:I282 28.59215.02YesNo065
89R:R:F207 R:R:N283 52.5913.62YesNo069
90R:R:G210 R:R:N283 50.26271.7NoNo079
91R:R:G210 R:R:L323 47.91631.71NoNo078
92R:R:L287 R:R:L323 20.27544.15YesNo778
93R:R:L287 R:R:L319 15.83625.54YesNo079
94R:R:L213 R:R:L319 13.25424.15NoNo089
95R:R:I217 R:R:L213 10.6454.28NoNo078
96R:R:F286 R:R:I282 26.08263.77NoNo075
97R:R:F286 R:R:H214 23.55528.28NoNo077
98R:R:H214 R:R:V218 10.64516.61NoNo076
99R:R:L251 R:R:N255 14.50441.37NoNo024
100R:R:L251 R:R:Y252 12.13084.69NoNo023
101R:R:K250 R:R:T268 10.454810.51YesNo064
102R:R:E256 R:R:K257 18.44548.1NoNo033
103R:R:E256 R:R:R263 10.57268.14NoYes333
104R:R:I325 R:R:L323 25.25824.28YesNo768
105R:R:I325 R:R:M328 13.26332.92YesYes064
106R:R:H214 R:R:N289 10.6452.55NoNo076
107R:R:V318 R:R:Y363 18.86212.52NoNo068
108R:R:I325 R:R:L320 10.53635.71YesNo067
109R:R:T326 R:R:Y327 11.40613.75NoYes088
110L:L:L13 L:L:L9 14.03334.15NoNo000
111L:L:L9 R:R:E352 16.00835.3NoYes008
112L:L:T23 R:R:N107 12.49325.85NoNo004
113R:R:L144 R:R:R377 12.18521.21NoNo064
114R:R:H117 R:R:K113 12.09463.93NoYes421
115R:R:F162 R:R:Q355 45.70577.03YesYes179
116R:R:F141 R:R:N152 43.4596.04NoNo078
117R:R:I154 R:R:W205 55.76194.7NoYes089
118R:R:W246 R:R:Y272 20.864311.58YesYes187
119R:R:Q273 R:R:Y272 27.21519.02YesYes177
120L:L:I7 R:R:Q273 30.57624.12YesYes107
121L:L:T10 R:R:Y195 34.444611.24NoYes105
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Q26 R:R:L106 3.99 0 No No 0 3 0 1
L:L:T23 R:R:N107 5.85 0 No No 0 4 0 1
L:L:R27 R:R:E109 8.14 0 No No 0 2 0 1
R:R:H117 R:R:K113 3.93 4 No Yes 2 1 1 1
L:L:L20 R:R:K113 12.69 4 No Yes 0 1 0 1
L:L:L20 R:R:H117 3.86 4 No No 0 2 0 1
L:L:L17 R:R:V120 5.96 0 No No 0 4 0 1
R:R:H127 R:R:N123 3.83 1 Yes No 7 7 2 2
R:R:N123 R:R:W169 3.39 1 No Yes 7 7 2 1
R:R:N123 R:R:S349 8.94 1 No No 7 6 2 1
R:R:Q173 R:R:Y124 3.38 0 No No 7 6 1 2
R:R:H127 R:R:W169 13.75 1 Yes Yes 7 7 2 1
R:R:E352 R:R:R165 3.49 0 Yes Yes 8 8 1 2
R:R:T168 R:R:Y195 4.99 0 No Yes 4 5 2 1
R:R:F170 R:R:W169 4.01 0 No Yes 7 7 2 1
R:R:Q173 R:R:W169 14.24 0 No Yes 7 7 1 1
R:R:W169 R:R:Y195 7.72 1 Yes Yes 7 5 1 1
L:L:T10 R:R:W169 7.28 1 No Yes 0 7 0 1
R:R:V172 R:R:Y195 3.79 0 No Yes 6 5 2 1
L:L:L14 R:R:Q173 5.32 0 No No 0 7 0 1
R:R:P178 R:R:S177 3.56 0 No No 2 4 1 2
L:L:L18 R:R:P178 3.28 0 No No 0 2 0 1
R:R:H181 R:R:K257 13.1 0 No No 4 3 1 2
R:R:F260 R:R:H181 5.66 1 No No 6 4 1 1
L:L:L18 R:R:H181 5.14 0 No No 0 4 0 1
L:L:T10 R:R:Y195 11.24 1 No Yes 0 5 0 1
L:L:F11 R:R:Y195 4.13 1 Yes Yes 0 5 0 1
R:R:N196 R:R:W246 6.78 1 No Yes 8 8 1 2
R:R:N196 R:R:Y272 15.12 1 No Yes 8 7 1 1
L:L:F11 R:R:N196 8.46 1 Yes No 0 8 0 1
R:R:F203 R:R:H199 12.44 1 Yes No 8 5 1 2
R:R:H199 R:R:M276 3.94 1 No No 5 7 2 1
R:R:F203 R:R:M206 8.71 1 Yes Yes 8 9 1 2
R:R:F203 R:R:M276 7.46 1 Yes No 8 7 1 1
R:R:F203 R:R:Y327 8.25 1 Yes Yes 8 8 1 1
L:L:I7 R:R:F203 3.77 1 Yes Yes 0 8 0 1
R:R:M206 R:R:Q355 4.08 1 Yes Yes 9 9 2 2
R:R:W246 R:R:Y272 11.58 1 Yes Yes 8 7 2 1
L:L:F11 R:R:F260 8.57 1 Yes No 0 6 0 1
L:L:R15 R:R:K262 8.66 0 No No 0 5 0 1
R:R:Y267 R:R:Y270 6.95 0 No No 1 7 2 1
R:R:D269 R:R:Y272 9.2 0 No Yes 6 7 2 1
R:R:Q273 R:R:Y270 3.38 1 Yes No 7 7 1 1
R:R:Q273 R:R:Y272 9.02 1 Yes Yes 7 7 1 1
L:L:D8 R:R:Y272 3.45 1 Yes Yes 0 7 0 1
L:L:L5 R:R:Q273 3.99 1 No Yes 0 7 0 1
L:L:I7 R:R:Q273 4.12 1 Yes Yes 0 7 0 1
L:L:D8 R:R:Q273 5.22 1 Yes Yes 0 7 0 1
L:L:I7 R:R:M276 4.37 1 Yes No 0 7 0 1
R:R:F331 R:R:I277 5.02 0 Yes No 5 3 1 2
R:R:T326 R:R:Y327 3.75 0 No Yes 8 8 2 1
R:R:E352 R:R:Y327 4.49 0 Yes Yes 8 8 1 1
R:R:Q355 R:R:Y327 10.15 1 Yes Yes 9 8 2 1
L:L:I7 R:R:Y327 3.63 1 Yes Yes 0 8 0 1
R:R:F331 R:R:V332 5.24 0 Yes No 5 5 1 2
L:L:L5 R:R:F331 9.74 1 No Yes 0 5 0 1
L:L:S6 R:R:F331 5.28 0 No Yes 0 5 0 1
R:R:F344 R:R:N348 7.25 0 No No 6 8 2 1
L:L:L13 R:R:I345 5.71 0 No No 0 7 0 1
L:L:S6 R:R:N348 8.94 0 No No 0 8 0 1
L:L:L9 R:R:S349 4.5 0 No No 0 6 0 1
L:L:L9 R:R:E352 5.3 0 No Yes 0 8 0 1
L:L:T10 R:R:E352 4.23 1 No Yes 0 8 0 1
R:R:P264 R:R:R263 2.88 0 No Yes 5 3 1 2
L:L:P3 R:R:Y270 2.78 0 No No 0 7 0 1
L:L:Q24 R:R:K113 2.71 0 No Yes 0 1 0 1
R:R:F260 R:R:T192 2.59 1 No No 6 7 1 1
L:L:F11 R:R:T192 2.59 1 Yes No 0 7 0 1
L:L:L17 R:R:H117 2.57 0 No No 0 2 0 1
R:R:V120 R:R:Y124 2.52 0 No No 4 6 1 2
L:L:R22 R:R:Q182 2.34 0 No No 0 2 0 1
L:L:A21 R:R:P178 1.87 0 No No 0 2 0 1
L:L:N2 R:R:P264 1.63 0 No No 0 5 0 1
R:R:E109 R:R:K113 1.35 0 No Yes 2 1 1 1
L:L:E19 R:R:N107 1.31 0 No No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6PB0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.28
Number of Linked Nodes 284
Number of Links 307
Number of Hubs 38
Number of Links mediated by Hubs 139
Number of Communities 7
Number of Nodes involved in Communities 49
Number of Links involved in Communities 66
Path Summary
Number Of Nodes in MetaPath 122
Number Of Links MetaPath 121
Number of Shortest Paths 41098
Length Of Smallest Path 3
Average Path Length 14.1136
Length of Longest Path 36
Minimum Path Strength 1.07
Average Path Strength 6.11748
Maximum Path Strength 22.445
Minimum Path Correlation 0.7
Average Path Correlation 0.951917
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 68.1204
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.9624
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP34998-2
Sequence
>6PB0_nogp_Chain_R
LNEEKKSKV HYHVAVIIN YLGHCISLV ALLVAFVLF LRLRSIRCL 
RNIIHWNLI SAFILRNAT WFVVQLTMS PEVHQSNVG WCRLVTAAY 
NYFHVTNFF WMFGEGCYL HTAIVLTYS TDRLRKWMF ICIGWGVPF 
PIIVAWAIG KLYYDNEKC WFGKRPGVY TDYIYQGPM ILVLLINFI 
FLFNIVRIL MTKLRASTT SETIQYRKA VKATLVLLP LLGITYMLF 
FVNPGEDEV SRVVFIYFN SFLESFQGF FVSVFYCFL NSEVRSAIR 
KRWHRWQDK HS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinUrocortin
UniProtP55089
Sequence
>6PB0_nogp_Chain_L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4K5YB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-CP-376395-2.982013-07-17doi.org/10.1038/nature12357
4Z9GB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-CP-376395-3.182016-06-29doi.org/10.2174/1874467210666170110114727
6P9XB1PeptideCorticotropin Releasing FactorCRF1Homo sapiensCorticoliberin-1-Gs/β1/γ22.912020-02-05doi.org/10.1016/j.molcel.2020.01.012
6P9X (No Gprot) B1PeptideCorticotropin Releasing FactorCRF1Homo sapiensCorticoliberin-1-2.912020-02-05doi.org/10.1016/j.molcel.2020.01.012
6PB0B1PeptideCorticotropin Releasing FactorCRF1Homo sapiensUrocortin-chim(NtGi1-Gs)/β1/γ232020-02-12doi.org/10.1016/j.molcel.2020.01.013
6PB0 (No Gprot) B1PeptideCorticotropin Releasing FactorCRF1Homo sapiensUrocortin-32020-02-12doi.org/10.1016/j.molcel.2020.01.013
8GTGB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-BMK-I152-2.752023-09-13doi.org/10.1038/s12276-023-01082-1
8GTIB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-BMK-C205-2.22023-09-13doi.org/10.1038/s12276-023-01082-1
8GTMB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-BMK-C203-2.62023-09-13doi.org/10.1038/s12276-023-01082-1




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6PB0_nogp.zip



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