psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q26	R:R:L106	3.99	No	No	0	0	3
2	L:L:T23	R:R:N107	5.85	No	No	0	0	4
3	L:L:R27	R:R:E109	8.14	No	No	0	0	2
4	R:R:H115	R:R:S112	5.58	No	No	0	4	2
5	R:R:S112	R:R:Y116	13.99	No	No	0	2	3
6	R:R:H117	R:R:K113	3.93	No	Yes	4	2	1
7	L:L:L20	R:R:K113	12.69	No	Yes	4	0	1
8	R:R:H115	R:R:V342	4.15	No	No	0	4	3
9	R:R:H115	R:R:Y346	7.62	No	Yes	0	4	6
10	L:L:L20	R:R:H117	3.86	No	No	4	0	2
11	R:R:A119	R:R:Y346	4	No	Yes	0	6	6
12	L:L:L17	R:R:V120	5.96	No	No	0	0	4
13	R:R:H127	R:R:N123	3.83	Yes	No	1	7	7
14	R:R:N123	R:R:W169	3.39	No	Yes	1	7	7
15	R:R:N123	R:R:S349	8.94	No	No	0	7	6
16	R:R:Q173	R:R:Y124	3.38	No	No	0	7	6
17	R:R:G126	R:R:L125	3.42	No	No	0	8	6
18	R:R:G126	R:R:I129	3.53	No	No	5	8	5
19	R:R:F354	R:R:G126	6.02	Yes	No	5	6	8
20	R:R:H127	R:R:N166	5.1	Yes	No	0	7	7
21	R:R:H127	R:R:W169	13.75	Yes	Yes	1	7	7
22	R:R:H127	R:R:S353	9.76	Yes	No	0	7	8
23	R:R:F354	R:R:I129	5.02	Yes	No	5	6	5
24	R:R:N166	R:R:S130	4.47	No	No	0	7	9
25	R:R:L131	R:R:L135	4.15	No	No	0	6	3
26	R:R:A133	R:R:S360	3.42	No	No	0	6	8
27	R:R:I159	R:R:L134	5.71	No	No	0	7	8
28	R:R:I163	R:R:L134	4.28	No	No	0	7	8
29	R:R:L134	R:R:S360	4.5	No	No	0	8	8
30	R:R:I163	R:R:L135	5.71	No	No	0	7	3
31	R:R:A137	R:R:C364	3.61	No	No	0	8	8
32	R:R:F138	R:R:W156	10.02	No	No	0	6	5
33	R:R:F138	R:R:I163	3.77	No	No	0	6	7
34	R:R:F141	R:R:N152	6.04	No	No	0	7	8
35	R:R:F141	R:R:W156	16.04	No	No	0	7	5
36	R:R:A373	R:R:L144	4.73	No	No	0	7	6
37	R:R:R145	R:R:R148	4.26	No	No	0	6	7
38	R:R:I147	R:R:N152	9.91	No	No	0	7	8
39	R:R:E369	R:R:I147	12.3	No	No	0	8	7
40	R:R:L150	R:R:Y212	5.86	No	No	0	6	7
41	R:R:N152	R:R:R151	8.44	No	Yes	0	8	8
42	R:R:H155	R:R:R151	4.51	Yes	Yes	0	9	8
43	R:R:R151	R:R:Y212	4.12	Yes	No	0	8	7
44	R:R:I153	R:R:K228	4.36	No	No	0	6	5
45	R:R:I154	R:R:W205	4.7	No	Yes	0	8	9
46	R:R:E209	R:R:I154	6.83	Yes	No	0	9	8
47	R:R:F231	R:R:I154	5.02	Yes	No	0	6	8
48	R:R:E209	R:R:H155	19.69	Yes	Yes	2	9	9
49	R:R:H155	R:R:L322	3.86	Yes	No	2	9	8
50	R:R:H155	R:R:Y363	7.62	Yes	No	2	9	8
51	R:R:N157	R:R:W205	13.56	No	Yes	0	9	9
52	R:R:F162	R:R:L158	6.09	Yes	No	0	7	8
53	R:R:E209	R:R:L158	3.98	Yes	No	0	9	8
54	R:R:F162	R:R:R165	5.34	Yes	Yes	1	7	8
55	R:R:F162	R:R:N202	21.75	Yes	No	1	7	7
56	R:R:F162	R:R:Q355	7.03	Yes	Yes	1	7	9
57	R:R:F162	R:R:G356	6.02	Yes	No	0	7	9
58	R:R:F198	R:R:L164	17.05	No	No	0	6	5
59	R:R:N166	R:R:R165	3.62	No	Yes	0	7	8
60	R:R:N202	R:R:R165	8.44	No	Yes	1	7	8
61	R:R:E352	R:R:R165	3.49	Yes	Yes	0	8	8
62	R:R:T168	R:R:Y195	4.99	No	Yes	0	4	5
63	R:R:F198	R:R:T168	5.19	No	No	0	6	4
64	R:R:F170	R:R:W169	4.01	No	Yes	0	7	7
65	R:R:Q173	R:R:W169	14.24	No	Yes	0	7	7
66	R:R:W169	R:R:Y195	7.72	Yes	Yes	1	7	5
67	L:L:T10	R:R:W169	7.28	No	Yes	1	0	7
68	R:R:V172	R:R:Y195	3.79	No	Yes	0	6	5
69	L:L:L14	R:R:Q173	5.32	No	No	0	0	7
70	R:R:T175	R:R:W187	6.06	No	No	0	3	2
71	R:R:P178	R:R:S177	3.56	No	No	0	2	4
72	L:L:L18	R:R:P178	3.28	No	No	0	0	2
73	R:R:V180	R:R:W187	7.36	No	No	0	2	2
74	R:R:C188	R:R:V180	3.42	No	No	0	9	2
75	R:R:H181	R:R:K257	13.1	No	No	0	4	3
76	R:R:F260	R:R:H181	5.66	No	No	0	6	4
77	L:L:L18	R:R:H181	5.14	No	No	0	0	4
78	R:R:V185	R:R:W187	7.36	No	No	0	3	2
79	R:R:G186	R:R:R189	4.5	No	Yes	0	2	6
80	R:R:C188	R:R:C258	7.28	No	No	0	9	9
81	R:R:N255	R:R:R189	3.62	No	Yes	1	4	6
82	R:R:R189	R:R:W259	16.99	Yes	Yes	1	6	9
83	L:L:T10	R:R:Y195	11.24	No	Yes	1	0	5
84	L:L:F11	R:R:Y195	4.13	Yes	Yes	1	0	5
85	R:R:N196	R:R:W246	6.78	No	Yes	1	8	8
86	R:R:N196	R:R:Y272	15.12	No	Yes	1	8	7
87	L:L:F11	R:R:N196	8.46	Yes	No	1	0	8
88	R:R:F198	R:R:Y197	4.13	No	No	0	6	8
89	R:R:T201	R:R:Y197	8.74	Yes	No	0	7	8
90	R:R:I243	R:R:Y197	7.25	No	No	0	7	8
91	R:R:F203	R:R:H199	12.44	Yes	No	1	8	5
92	R:R:H199	R:R:M276	3.94	No	No	1	5	7
93	R:R:P239	R:R:V200	5.3	Yes	No	0	9	7
94	R:R:T201	R:R:W236	7.28	Yes	No	0	7	9
95	R:R:P239	R:R:T201	5.25	Yes	Yes	0	9	7
96	R:R:M206	R:R:N202	5.61	Yes	No	1	9	7
97	R:R:F203	R:R:M206	8.71	Yes	Yes	1	8	9
98	R:R:F203	R:R:M276	7.46	Yes	No	1	8	7
99	R:R:F203	R:R:Y327	8.25	Yes	Yes	1	8	8
100	L:L:I7	R:R:F203	3.77	Yes	Yes	1	0	8
101	R:R:F204	R:R:V238	5.24	Yes	No	6	5	3
102	R:R:F204	R:R:P239	4.33	Yes	Yes	6	5	9
103	R:R:G235	R:R:W205	8.44	No	Yes	0	8	9
104	R:R:W205	R:R:W236	13.12	Yes	No	0	9	9
105	R:R:G324	R:R:M206	3.49	No	Yes	1	9	9
106	R:R:M206	R:R:Q355	4.08	Yes	Yes	1	9	9
107	R:R:F207	R:R:V279	3.93	Yes	No	0	6	7
108	R:R:F207	R:R:I282	5.02	Yes	No	0	6	5
109	R:R:F207	R:R:N283	3.62	Yes	No	0	6	9
110	R:R:E209	R:R:L322	9.28	Yes	No	2	9	8
111	R:R:F231	R:R:Y212	4.13	Yes	No	0	6	7
112	R:R:I217	R:R:L213	4.28	No	No	0	7	8
113	R:R:L213	R:R:L319	4.15	No	No	0	8	9
114	R:R:H214	R:R:V218	16.61	No	No	0	7	6
115	R:R:F286	R:R:H214	28.28	No	No	0	7	7
116	R:R:L226	R:R:T215	7.37	No	No	0	4	6
117	R:R:I217	R:R:I293	4.42	No	No	0	7	6
118	R:R:F231	R:R:L226	8.53	Yes	No	0	6	4
119	R:R:R227	R:R:W229	6	No	No	0	4	2
120	R:R:I232	R:R:K228	5.82	No	No	0	4	5
121	R:R:M230	R:R:W229	10.47	No	No	0	3	2
122	R:R:P239	R:R:V238	3.53	Yes	No	6	9	3
123	R:R:F240	R:R:P241	4.33	No	No	0	4	4
124	R:R:F240	R:R:V244	6.55	No	No	0	4	3
125	R:R:K250	R:R:W246	13.92	Yes	Yes	1	6	8
126	R:R:W246	R:R:W259	4.69	Yes	Yes	1	8	9
127	R:R:I271	R:R:W246	3.52	No	Yes	0	7	8
128	R:R:W246	R:R:Y272	11.58	Yes	Yes	1	8	7
129	R:R:K250	R:R:W259	16.24	Yes	Yes	1	6	9
130	R:R:K250	R:R:T268	10.51	Yes	No	0	6	4
131	R:R:D269	R:R:K250	6.91	No	Yes	0	6	6
132	R:R:L251	R:R:Y252	4.69	No	No	0	2	3
133	R:R:D254	R:R:E256	9.09	No	No	3	5	3
134	R:R:D254	R:R:R263	14.29	No	Yes	3	5	3
135	R:R:D254	R:R:V266	7.3	No	No	3	5	3
136	R:R:N255	R:R:W259	10.17	No	Yes	1	4	9
137	R:R:E256	R:R:K257	8.1	No	No	0	3	3
138	R:R:E256	R:R:R263	8.14	No	Yes	3	3	3
139	R:R:G261	R:R:K257	3.49	No	No	0	5	3
140	L:L:F11	R:R:F260	8.57	Yes	No	1	0	6
141	L:L:R15	R:R:K262	8.66	No	No	0	0	5
142	R:R:R263	R:R:V266	5.23	Yes	No	3	3	3
143	R:R:Y267	R:R:Y270	6.95	No	No	0	1	7
144	R:R:D269	R:R:Y272	9.2	No	Yes	0	6	7
145	R:R:Q273	R:R:Y270	3.38	Yes	No	0	7	7
146	R:R:Q273	R:R:Y272	9.02	Yes	Yes	1	7	7
147	L:L:D8	R:R:Y272	3.45	Yes	Yes	1	0	7
148	L:L:L5	R:R:Q273	3.99	No	Yes	1	0	7
149	L:L:I7	R:R:Q273	4.12	Yes	Yes	1	0	7
150	L:L:D8	R:R:Q273	5.22	Yes	Yes	1	0	7
151	R:R:G274	R:R:P275	4.06	No	No	0	3	8
152	L:L:I7	R:R:M276	4.37	Yes	No	1	0	7
153	R:R:F331	R:R:I277	5.02	Yes	No	0	5	3
154	R:R:L280	R:R:M328	4.24	No	Yes	0	6	4
155	R:R:F286	R:R:I282	3.77	No	No	0	7	5
156	R:R:F284	R:R:M328	4.98	No	Yes	0	4	4
157	R:R:L287	R:R:L319	5.54	Yes	No	0	7	9
158	R:R:L287	R:R:L323	4.15	Yes	No	7	7	8
159	R:R:I325	R:R:L287	4.28	Yes	Yes	7	6	7
160	R:R:F288	R:R:R292	5.34	No	No	0	4	6
161	R:R:M295	R:R:R299	4.96	No	No	0	4	5
162	R:R:L298	R:R:Q308	6.65	No	Yes	0	6	5
163	R:R:K311	R:R:L298	4.23	No	No	0	7	6
164	R:R:Q308	R:R:T302	5.67	Yes	No	0	5	4
165	R:R:I307	R:R:S304	6.19	No	No	0	5	3
166	R:R:K314	R:R:V318	4.55	No	No	0	8	6
167	R:R:I325	R:R:L320	5.71	Yes	No	0	6	7
168	R:R:L322	R:R:Y363	15.24	No	No	2	8	8
169	R:R:I325	R:R:L323	4.28	Yes	No	7	6	8
170	R:R:G324	R:R:Q355	3.29	No	Yes	1	9	9
171	R:R:T326	R:R:Y327	3.75	No	Yes	0	8	8
172	R:R:L351	R:R:T326	8.84	No	No	0	5	8
173	R:R:E352	R:R:Y327	4.49	Yes	Yes	0	8	8
174	R:R:Q355	R:R:Y327	10.15	Yes	Yes	1	9	8
175	L:L:I7	R:R:Y327	3.63	Yes	Yes	1	0	8
176	R:R:F347	R:R:L329	6.09	No	No	0	5	6
177	R:R:F330	R:R:S340	3.96	No	No	0	7	2
178	R:R:F330	R:R:F344	7.5	No	No	0	7	6
179	R:R:F331	R:R:V332	5.24	Yes	No	0	5	5
180	L:L:L5	R:R:F331	9.74	No	Yes	0	0	5
181	L:L:S6	R:R:F331	5.28	No	Yes	0	0	5
182	R:R:N333	R:R:P334	6.52	No	No	0	6	5
183	R:R:N333	R:R:R341	4.82	No	No	0	6	4
184	R:R:P334	R:R:S340	3.56	No	No	0	5	2
185	R:R:E336	R:R:E338	8.88	No	No	0	3	3
186	R:R:D337	R:R:R341	4.76	No	No	0	3	4
187	R:R:E338	R:R:S340	4.31	No	No	0	3	2
188	R:R:F344	R:R:N348	7.25	No	No	0	6	8
189	L:L:L13	R:R:I345	5.71	No	No	0	0	7
190	R:R:F347	R:R:L351	6.09	No	No	0	5	5
191	L:L:S6	R:R:N348	8.94	No	No	0	0	8
192	L:L:L9	R:R:S349	4.5	No	No	0	0	6
193	R:R:F350	R:R:F354	13.93	No	Yes	0	5	6
194	L:L:L9	R:R:E352	5.3	No	Yes	0	0	8
195	L:L:T10	R:R:E352	4.23	No	Yes	0	0	8
196	R:R:F354	R:R:S353	5.28	Yes	No	0	6	8
197	R:R:F354	R:R:F358	4.29	Yes	No	0	6	6
198	R:R:F357	R:R:F358	4.29	No	No	0	5	6
199	R:R:F357	R:R:V361	6.55	No	No	0	5	5
200	R:R:F365	R:R:V361	3.93	Yes	No	0	6	5
201	R:R:F362	R:R:L366	3.65	No	No	0	8	5
202	R:R:N367	R:R:V370	5.91	No	No	0	9	9
203	R:R:K376	R:R:S372	4.59	No	No	0	5	4
204	R:R:Q382	R:R:W378	6.57	No	No	0	4	4
205	L:L:H12	L:L:S4	5.58	No	No	0	0	0
206	L:L:I7	L:L:L5	4.28	Yes	No	1	0	0
207	L:L:D8	L:L:F11	8.36	Yes	Yes	1	0	0
208	L:L:D8	L:L:R15	3.57	Yes	No	0	0	0
209	L:L:L13	L:L:L9	4.15	No	No	0	0	0
210	L:L:H12	L:L:T16	4.11	No	No	0	0	0
211	L:L:E19	L:L:R22	3.49	No	No	0	0	0
212	L:L:F37	L:L:N33	14.5	No	No	0	0	0
213	R:R:C188	R:R:M176	3.24	No	No	0	9	6
214	R:R:S177	R:R:V180	3.23	No	No	0	4	2
215	R:R:V171	R:R:V191	3.21	No	No	0	4	5
216	R:R:R341	R:R:Y116	3.09	No	No	0	4	3
217	R:R:I307	R:R:T302	3.04	No	No	0	5	4
218	R:R:F231	R:R:G208	3.01	Yes	No	0	6	7
219	R:R:R148	R:R:W156	3	No	No	0	7	5
220	R:R:L219	R:R:S222	3	No	No	0	4	5
221	R:R:L219	R:R:V218	2.98	No	No	0	4	6
222	R:R:L287	R:R:V291	2.98	Yes	No	0	7	6
223	R:R:L317	R:R:V313	2.98	No	No	0	5	5
224	R:R:L320	R:R:T316	2.95	No	No	0	7	7
225	L:L:L13	L:L:T16	2.95	No	No	0	0	0
226	R:R:I217	R:R:I290	2.94	No	No	0	7	8
227	R:R:I325	R:R:M328	2.92	Yes	Yes	0	6	4
228	R:R:F358	R:R:P321	2.89	No	No	0	6	7
229	R:R:P264	R:R:R263	2.88	No	Yes	0	5	3
230	R:R:K228	R:R:L150	2.82	No	No	0	5	6
231	R:R:C128	R:R:F170	2.79	No	No	0	6	7
232	R:R:C364	R:R:F141	2.79	No	No	0	8	7
233	R:R:C364	R:R:F365	2.79	No	Yes	0	8	6
234	L:L:P3	R:R:Y270	2.78	No	No	0	0	7
235	R:R:L294	R:R:L298	2.77	No	No	0	7	6
236	L:L:Q24	R:R:K113	2.71	No	Yes	0	0	1
237	R:R:R371	R:R:S368	2.64	No	No	0	7	4
238	R:R:F365	R:R:V136	2.62	Yes	No	0	6	5
239	R:R:R143	R:R:V139	2.62	No	No	0	1	3
240	R:R:F204	R:R:V279	2.62	Yes	No	0	5	7
241	R:R:F362	R:R:V318	2.62	No	No	0	8	6
242	R:R:F260	R:R:T192	2.59	No	No	1	6	7
243	L:L:F11	R:R:T192	2.59	Yes	No	1	0	7
244	R:R:A247	R:R:W259	2.59	No	Yes	0	5	9
245	L:L:L17	R:R:H117	2.57	No	No	0	0	2
246	R:R:H214	R:R:N289	2.55	No	No	0	7	6
247	R:R:E305	R:R:Q308	2.55	No	Yes	0	4	5
248	R:R:V118	R:R:Y346	2.52	No	Yes	0	4	6
249	R:R:V120	R:R:Y124	2.52	No	No	0	4	6
250	R:R:V318	R:R:Y363	2.52	No	No	0	6	8
251	R:R:F204	R:R:I242	2.51	Yes	No	0	5	6
252	R:R:F207	R:R:I234	2.51	Yes	No	0	6	5
253	R:R:T268	R:R:Y253	2.5	No	No	0	4	6
254	R:R:H379	R:R:Q382	2.47	No	No	0	3	4
255	R:R:F365	R:R:L140	2.44	Yes	No	0	6	8
256	R:R:I122	R:R:Y346	2.42	No	Yes	0	7	6
257	R:R:I248	R:R:Y252	2.42	No	No	0	4	3
258	R:R:N367	R:R:R151	2.41	No	Yes	0	9	8
259	R:R:N184	R:R:R189	2.41	No	Yes	0	6	6
260	R:R:N289	R:R:R292	2.41	No	No	0	6	6
261	R:R:D224	R:R:R227	2.38	No	No	0	5	4
262	L:L:R22	R:R:Q182	2.34	No	No	0	0	2
263	R:R:Q308	R:R:R299	2.34	Yes	No	0	5	5
264	R:R:G237	R:R:P239	2.03	No	Yes	0	6	9
265	R:R:C211	R:R:G208	1.96	No	No	0	5	7
266	L:L:A21	R:R:P178	1.87	No	No	0	0	2
267	R:R:G356	R:R:V359	1.84	No	No	0	9	9
268	R:R:G249	R:R:T268	1.82	No	No	0	4	4
269	R:R:G210	R:R:L323	1.71	No	No	0	7	8
270	R:R:G210	R:R:N283	1.7	No	No	0	7	9
271	R:R:I242	R:R:P275	1.69	No	No	0	6	8
272	R:R:A161	R:R:T201	1.68	No	Yes	0	8	7
273	R:R:A194	R:R:T168	1.68	No	No	0	4	4
274	L:L:N2	R:R:P264	1.63	No	No	0	0	5
275	R:R:S183	R:R:V185	1.62	No	No	0	2	3
276	R:R:A245	R:R:I271	1.62	No	No	0	5	7
277	L:L:S39	L:L:V40	1.62	No	No	0	0	0
278	R:R:A312	R:R:M295	1.61	No	No	0	7	4
279	R:R:V172	R:R:V191	1.6	No	No	0	6	5
280	R:R:C149	R:R:L150	1.59	No	No	0	6	6
281	R:R:A315	R:R:L294	1.58	No	No	0	8	7
282	R:R:I129	R:R:V132	1.54	No	No	0	5	3
283	R:R:I248	R:R:V244	1.54	No	No	0	4	3
284	R:R:L164	R:R:S160	1.5	No	No	0	5	3
285	R:R:L144	R:R:V370	1.49	No	No	0	6	9
286	R:R:N367	R:R:S368	1.49	No	No	0	9	4
287	L:L:L20	L:L:T23	1.47	No	No	0	0	0
288	R:R:I293	R:R:K297	1.45	No	No	0	6	8
289	R:R:E179	R:R:S177	1.44	No	No	0	1	4
290	R:R:I374	R:R:L140	1.43	No	No	0	5	8
291	R:R:I285	R:R:N289	1.42	No	No	0	3	6
292	L:L:I36	L:L:N33	1.42	No	No	0	0	0
293	R:R:L281	R:R:M328	1.41	No	Yes	0	4	4
294	R:R:L278	R:R:L281	1.38	No	No	0	3	4
295	R:R:L317	R:R:L320	1.38	No	No	0	5	7
296	R:R:L251	R:R:N255	1.37	No	No	0	2	4
297	L:L:E31	L:L:I35	1.37	No	No	0	0	0
298	L:L:I36	L:L:Q32	1.37	No	No	0	0	0
299	R:R:E109	R:R:K113	1.35	No	Yes	0	2	1
300	R:R:R225	R:R:S222	1.32	No	No	0	4	5
301	L:L:E19	R:R:N107	1.31	No	No	0	0	4
302	R:R:A193	R:R:W246	1.3	No	Yes	0	5	8
303	R:R:L144	R:R:R377	1.21	No	No	0	6	4
304	R:R:Q308	R:R:Y309	1.13	Yes	No	0	5	4
305	R:R:R143	R:R:R377	1.07	No	No	0	1	4
306	R:R:R377	R:R:R380	1.07	No	No	0	4	5
307	R:R:W378	R:R:W381	0.94	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K113	5.17	4	4	1
2	R:R:H127	8.11	4	1	7
3	R:R:R151	4.87	4	0	8
4	R:R:H155	8.92	4	2	9
5	R:R:F162	9.246	5	1	7
6	R:R:R165	5.2225	4	1	8
7	R:R:W169	8.39833	6	1	7
8	R:R:R189	6.88	4	1	6
9	R:R:Y195	6.374	5	1	5
10	R:R:T201	5.7375	4	0	7
11	R:R:F203	8.126	5	1	8
12	R:R:F204	3.675	4	6	5
13	R:R:W205	9.955	4	0	9
14	R:R:M206	5.4725	4	1	9
15	R:R:F207	3.77	4	0	6
16	R:R:E209	9.945	4	2	9
17	R:R:F231	5.1725	4	0	6
18	R:R:P239	4.088	5	6	9
19	R:R:W246	6.965	6	1	8
20	R:R:K250	11.895	4	1	6
21	R:R:W259	10.136	5	1	9
22	R:R:R263	7.635	4	3	3
23	R:R:Y272	9.674	5	1	7
24	R:R:Q273	5.146	5	1	7
25	R:R:L287	4.2375	4	7	7
26	R:R:Q308	3.668	5	0	5
27	R:R:I325	4.2975	4	7	6
28	R:R:Y327	6.054	5	1	8
29	R:R:M328	3.3875	4	0	4
30	R:R:F331	6.32	4	0	5
31	R:R:Y346	4.14	4	0	6
32	R:R:E352	4.3775	4	0	8
33	R:R:F354	6.908	5	5	6
34	R:R:Q355	6.1375	4	1	9
35	R:R:F365	2.945	4	0	6
36	L:L:I7	4.034	5	1	0
37	L:L:D8	5.15	4	1	0
38	L:L:F11	6.422	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L20	L:L:T23	15.5735	1.47	No	No	0	0	0
2	L:L:L20	R:R:H117	18.4182	3.86	No	No	4	0	2
3	L:L:L17	R:R:H117	33.4934	2.57	No	No	0	0	2
4	L:L:L17	R:R:V120	36.4468	5.96	No	No	0	0	4
5	R:R:V120	R:R:Y124	39.3821	2.52	No	No	0	4	6
6	R:R:Q173	R:R:Y124	42.2993	3.38	No	No	0	7	6
7	R:R:Q173	R:R:W169	48.0794	14.24	No	Yes	0	7	7
8	R:R:W169	R:R:Y195	51.5764	7.72	Yes	Yes	1	7	5
9	L:L:F11	R:R:Y195	100	4.13	Yes	Yes	1	0	5
10	L:L:D8	L:L:F11	39.4908	8.36	Yes	Yes	1	0	0
11	L:L:D8	R:R:Q273	36.4649	5.22	Yes	Yes	1	0	7
12	L:L:L5	R:R:Q273	31.8717	3.99	No	Yes	1	0	7
13	L:L:L5	R:R:F331	60.7809	9.74	No	Yes	0	0	5
14	L:L:S6	R:R:F331	53.0078	5.28	No	Yes	0	0	5
15	L:L:S6	R:R:N348	50.3805	8.94	No	No	0	0	8
16	R:R:F344	R:R:N348	47.7351	7.25	No	No	0	6	8
17	R:R:F330	R:R:F344	45.0716	7.5	No	No	0	7	6
18	R:R:F330	R:R:S340	42.3899	3.96	No	No	0	7	2
19	R:R:P334	R:R:S340	34.2363	3.56	No	No	0	5	2
20	R:R:N333	R:R:P334	31.4822	6.52	No	No	0	6	5
21	R:R:N333	R:R:R341	28.7099	4.82	No	No	0	6	4
22	R:R:R341	R:R:Y116	23.1111	3.09	No	No	0	4	3
23	R:R:S112	R:R:Y116	20.2845	13.99	No	No	0	2	3
24	R:R:H115	R:R:S112	17.4398	5.58	No	No	0	4	2
25	L:L:T10	R:R:W169	22.0692	7.28	No	Yes	1	0	7
26	L:L:T10	R:R:E352	56.1515	4.23	No	Yes	0	0	8
27	R:R:E352	R:R:Y327	30.2319	4.49	Yes	Yes	0	8	8
28	L:L:I7	R:R:Y327	58.8422	3.63	Yes	Yes	1	0	8
29	L:L:I7	L:L:L5	31.455	4.28	Yes	No	1	0	0
30	R:R:H115	R:R:Y346	11.696	7.62	No	Yes	0	4	6
31	R:R:H127	R:R:W169	44.5189	13.75	Yes	Yes	1	7	7
32	R:R:H127	R:R:S353	41.4024	9.76	Yes	No	0	7	8
33	R:R:F354	R:R:S353	39.0107	5.28	Yes	No	0	6	8
34	R:R:H127	R:R:N166	20.8099	5.1	Yes	No	0	7	7
35	R:R:F354	R:R:F358	26.4541	4.29	Yes	No	0	6	6
36	R:R:F357	R:R:F358	22.6309	4.29	No	No	0	5	6
37	R:R:F357	R:R:V361	20.8462	6.55	No	No	0	5	5
38	R:R:F365	R:R:V361	19.8858	3.93	Yes	No	0	6	5
39	R:R:C364	R:R:F365	19.5416	2.79	No	Yes	0	8	6
40	R:R:C364	R:R:F141	21.4985	2.79	No	No	0	8	7
41	R:R:F141	R:R:W156	34.5715	16.04	No	No	0	7	5
42	R:R:F138	R:R:W156	25.3579	10.02	No	No	0	6	5
43	R:R:F138	R:R:I163	22.2504	3.77	No	No	0	6	7
44	R:R:I163	R:R:L134	12.8194	4.28	No	No	0	7	8
45	R:R:N166	R:R:R165	20.2845	3.62	No	Yes	0	7	8
46	R:R:F162	R:R:R165	45.7239	5.34	Yes	Yes	1	7	8
47	R:R:F162	R:R:L158	93.0966	6.09	Yes	No	0	7	8
48	R:R:E209	R:R:L158	92.5439	3.98	Yes	No	0	9	8
49	R:R:E209	R:R:H155	76.8799	19.69	Yes	Yes	2	9	9
50	R:R:H155	R:R:R151	66.9596	4.51	Yes	Yes	0	9	8
51	R:R:N152	R:R:R151	51.1234	8.44	No	Yes	0	8	8
52	R:R:E352	R:R:R165	40.424	3.49	Yes	Yes	0	8	8
53	R:R:N367	R:R:R151	30.0236	2.41	No	Yes	0	9	8
54	R:R:N367	R:R:V370	21.2176	5.91	No	No	0	9	9
55	R:R:L144	R:R:V370	18.2279	1.49	No	No	0	6	9
56	R:R:E209	R:R:I154	49.2934	6.83	Yes	No	0	9	8
57	R:R:F231	R:R:I154	42.9969	5.02	Yes	No	0	6	8
58	R:R:F231	R:R:Y212	32.8049	4.13	Yes	No	0	6	7
59	R:R:L150	R:R:Y212	21.5981	5.86	No	No	0	6	7
60	R:R:R151	R:R:Y212	30.4131	4.12	Yes	No	0	8	7
61	R:R:K228	R:R:L150	13.0096	2.82	No	No	0	5	6
62	R:R:T168	R:R:Y195	74.9321	4.99	No	Yes	0	4	5
63	R:R:F198	R:R:T168	73.5369	5.19	No	No	0	6	4
64	R:R:F198	R:R:Y197	72.8302	4.13	No	No	0	6	8
65	R:R:T201	R:R:Y197	72.5222	8.74	Yes	No	0	7	8
66	R:R:T201	R:R:W236	54.9375	7.28	Yes	No	0	7	9
67	R:R:W205	R:R:W236	54.7291	13.12	Yes	No	0	9	9
68	R:R:E209	R:R:L322	12.8465	9.28	Yes	No	2	9	8
69	R:R:H155	R:R:Y363	12.8375	7.62	Yes	No	2	9	8
70	R:R:L322	R:R:Y363	10.7266	15.24	No	No	2	8	8
71	R:R:Q355	R:R:Y327	43.6311	10.15	Yes	Yes	1	9	8
72	L:L:F11	R:R:F260	59.3495	8.57	Yes	No	1	0	6
73	R:R:F260	R:R:H181	57.293	5.66	No	No	0	6	4
74	L:L:L18	R:R:H181	33.5568	5.14	No	No	0	0	4
75	L:L:L18	R:R:P178	31.0835	3.28	No	No	0	0	2
76	R:R:P178	R:R:S177	26.0826	3.56	No	No	0	2	4
77	R:R:S177	R:R:V180	21.0092	3.23	No	No	0	4	2
78	R:R:V180	R:R:W187	10.645	7.36	No	No	0	2	2
79	R:R:H181	R:R:K257	23.555	13.1	No	No	0	4	3
80	L:L:F11	R:R:N196	28.9908	8.46	Yes	No	1	0	8
81	R:R:N196	R:R:W246	24.8143	6.78	No	Yes	1	8	8
82	R:R:W246	R:R:W259	27.8221	4.69	Yes	Yes	1	8	9
83	R:R:N255	R:R:W259	16.6697	10.17	No	Yes	1	4	9
84	R:R:P239	R:R:T201	99.239	5.25	Yes	Yes	0	9	7
85	R:R:F204	R:R:P239	91.0582	4.33	Yes	Yes	6	5	9
86	R:R:F204	R:R:V279	83.285	2.62	Yes	No	0	5	7
87	R:R:F207	R:R:V279	81.2104	3.93	Yes	No	0	6	7
88	R:R:F207	R:R:I282	28.5921	5.02	Yes	No	0	6	5
89	R:R:F207	R:R:N283	52.591	3.62	Yes	No	0	6	9
90	R:R:G210	R:R:N283	50.2627	1.7	No	No	0	7	9
91	R:R:G210	R:R:L323	47.9163	1.71	No	No	0	7	8
92	R:R:L287	R:R:L323	20.2754	4.15	Yes	No	7	7	8
93	R:R:L287	R:R:L319	15.8362	5.54	Yes	No	0	7	9
94	R:R:L213	R:R:L319	13.2542	4.15	No	No	0	8	9
95	R:R:I217	R:R:L213	10.645	4.28	No	No	0	7	8
96	R:R:F286	R:R:I282	26.0826	3.77	No	No	0	7	5
97	R:R:F286	R:R:H214	23.555	28.28	No	No	0	7	7
98	R:R:H214	R:R:V218	10.645	16.61	No	No	0	7	6
99	R:R:L251	R:R:N255	14.5044	1.37	No	No	0	2	4
100	R:R:L251	R:R:Y252	12.1308	4.69	No	No	0	2	3
101	R:R:K250	R:R:T268	10.4548	10.51	Yes	No	0	6	4
102	R:R:E256	R:R:K257	18.4454	8.1	No	No	0	3	3
103	R:R:E256	R:R:R263	10.5726	8.14	No	Yes	3	3	3
104	R:R:I325	R:R:L323	25.2582	4.28	Yes	No	7	6	8
105	R:R:I325	R:R:M328	13.2633	2.92	Yes	Yes	0	6	4
106	R:R:H214	R:R:N289	10.645	2.55	No	No	0	7	6
107	R:R:V318	R:R:Y363	18.8621	2.52	No	No	0	6	8
108	R:R:I325	R:R:L320	10.5363	5.71	Yes	No	0	6	7
109	R:R:T326	R:R:Y327	11.4061	3.75	No	Yes	0	8	8
110	L:L:L13	L:L:L9	14.0333	4.15	No	No	0	0	0
111	L:L:L9	R:R:E352	16.0083	5.3	No	Yes	0	0	8
112	L:L:T23	R:R:N107	12.4932	5.85	No	No	0	0	4
113	R:R:L144	R:R:R377	12.1852	1.21	No	No	0	6	4
114	R:R:H117	R:R:K113	12.0946	3.93	No	Yes	4	2	1
115	R:R:F162	R:R:Q355	45.7057	7.03	Yes	Yes	1	7	9
116	R:R:F141	R:R:N152	43.459	6.04	No	No	0	7	8
117	R:R:I154	R:R:W205	55.7619	4.7	No	Yes	0	8	9
118	R:R:W246	R:R:Y272	20.8643	11.58	Yes	Yes	1	8	7
119	R:R:Q273	R:R:Y272	27.2151	9.02	Yes	Yes	1	7	7
120	L:L:I7	R:R:Q273	30.5762	4.12	Yes	Yes	1	0	7
121	L:L:T10	R:R:Y195	34.4446	11.24	No	Yes	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q26	R:R:L106	3.99	0	No	No	0	3	0	1
L:L:T23	R:R:N107	5.85	0	No	No	0	4	0	1
L:L:R27	R:R:E109	8.14	0	No	No	0	2	0	1
R:R:H117	R:R:K113	3.93	4	No	Yes	2	1	1	1
L:L:L20	R:R:K113	12.69	4	No	Yes	0	1	0	1
L:L:L20	R:R:H117	3.86	4	No	No	0	2	0	1
L:L:L17	R:R:V120	5.96	0	No	No	0	4	0	1
R:R:H127	R:R:N123	3.83	1	Yes	No	7	7	2	2
R:R:N123	R:R:W169	3.39	1	No	Yes	7	7	2	1
R:R:N123	R:R:S349	8.94	1	No	No	7	6	2	1
R:R:Q173	R:R:Y124	3.38	0	No	No	7	6	1	2
R:R:H127	R:R:W169	13.75	1	Yes	Yes	7	7	2	1
R:R:E352	R:R:R165	3.49	0	Yes	Yes	8	8	1	2
R:R:T168	R:R:Y195	4.99	0	No	Yes	4	5	2	1
R:R:F170	R:R:W169	4.01	0	No	Yes	7	7	2	1
R:R:Q173	R:R:W169	14.24	0	No	Yes	7	7	1	1
R:R:W169	R:R:Y195	7.72	1	Yes	Yes	7	5	1	1
L:L:T10	R:R:W169	7.28	1	No	Yes	0	7	0	1
R:R:V172	R:R:Y195	3.79	0	No	Yes	6	5	2	1
L:L:L14	R:R:Q173	5.32	0	No	No	0	7	0	1
R:R:P178	R:R:S177	3.56	0	No	No	2	4	1	2
L:L:L18	R:R:P178	3.28	0	No	No	0	2	0	1
R:R:H181	R:R:K257	13.1	0	No	No	4	3	1	2
R:R:F260	R:R:H181	5.66	1	No	No	6	4	1	1
L:L:L18	R:R:H181	5.14	0	No	No	0	4	0	1
L:L:T10	R:R:Y195	11.24	1	No	Yes	0	5	0	1
L:L:F11	R:R:Y195	4.13	1	Yes	Yes	0	5	0	1
R:R:N196	R:R:W246	6.78	1	No	Yes	8	8	1	2
R:R:N196	R:R:Y272	15.12	1	No	Yes	8	7	1	1
L:L:F11	R:R:N196	8.46	1	Yes	No	0	8	0	1
R:R:F203	R:R:H199	12.44	1	Yes	No	8	5	1	2
R:R:H199	R:R:M276	3.94	1	No	No	5	7	2	1
R:R:F203	R:R:M206	8.71	1	Yes	Yes	8	9	1	2
R:R:F203	R:R:M276	7.46	1	Yes	No	8	7	1	1
R:R:F203	R:R:Y327	8.25	1	Yes	Yes	8	8	1	1
L:L:I7	R:R:F203	3.77	1	Yes	Yes	0	8	0	1
R:R:M206	R:R:Q355	4.08	1	Yes	Yes	9	9	2	2
R:R:W246	R:R:Y272	11.58	1	Yes	Yes	8	7	2	1
L:L:F11	R:R:F260	8.57	1	Yes	No	0	6	0	1
L:L:R15	R:R:K262	8.66	0	No	No	0	5	0	1
R:R:Y267	R:R:Y270	6.95	0	No	No	1	7	2	1
R:R:D269	R:R:Y272	9.2	0	No	Yes	6	7	2	1
R:R:Q273	R:R:Y270	3.38	1	Yes	No	7	7	1	1
R:R:Q273	R:R:Y272	9.02	1	Yes	Yes	7	7	1	1
L:L:D8	R:R:Y272	3.45	1	Yes	Yes	0	7	0	1
L:L:L5	R:R:Q273	3.99	1	No	Yes	0	7	0	1
L:L:I7	R:R:Q273	4.12	1	Yes	Yes	0	7	0	1
L:L:D8	R:R:Q273	5.22	1	Yes	Yes	0	7	0	1
L:L:I7	R:R:M276	4.37	1	Yes	No	0	7	0	1
R:R:F331	R:R:I277	5.02	0	Yes	No	5	3	1	2
R:R:T326	R:R:Y327	3.75	0	No	Yes	8	8	2	1
R:R:E352	R:R:Y327	4.49	0	Yes	Yes	8	8	1	1
R:R:Q355	R:R:Y327	10.15	1	Yes	Yes	9	8	2	1
L:L:I7	R:R:Y327	3.63	1	Yes	Yes	0	8	0	1
R:R:F331	R:R:V332	5.24	0	Yes	No	5	5	1	2
L:L:L5	R:R:F331	9.74	1	No	Yes	0	5	0	1
L:L:S6	R:R:F331	5.28	0	No	Yes	0	5	0	1
R:R:F344	R:R:N348	7.25	0	No	No	6	8	2	1
L:L:L13	R:R:I345	5.71	0	No	No	0	7	0	1
L:L:S6	R:R:N348	8.94	0	No	No	0	8	0	1
L:L:L9	R:R:S349	4.5	0	No	No	0	6	0	1
L:L:L9	R:R:E352	5.3	0	No	Yes	0	8	0	1
L:L:T10	R:R:E352	4.23	1	No	Yes	0	8	0	1
R:R:P264	R:R:R263	2.88	0	No	Yes	5	3	1	2
L:L:P3	R:R:Y270	2.78	0	No	No	0	7	0	1
L:L:Q24	R:R:K113	2.71	0	No	Yes	0	1	0	1
R:R:F260	R:R:T192	2.59	1	No	No	6	7	1	1
L:L:F11	R:R:T192	2.59	1	Yes	No	0	7	0	1
L:L:L17	R:R:H117	2.57	0	No	No	0	2	0	1
R:R:V120	R:R:Y124	2.52	0	No	No	4	6	1	2
L:L:R22	R:R:Q182	2.34	0	No	No	0	2	0	1
L:L:A21	R:R:P178	1.87	0	No	No	0	2	0	1
L:L:N2	R:R:P264	1.63	0	No	No	0	5	0	1
R:R:E109	R:R:K113	1.35	0	No	Yes	2	1	1	1
L:L:E19	R:R:N107	1.31	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6PB0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	284
Number of Links	307
Number of Hubs	38
Number of Links mediated by Hubs	139
Number of Communities	7
Number of Nodes involved in Communities	49
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	122
Number Of Links MetaPath	121
Number of Shortest Paths	41098
Length Of Smallest Path	3
Average Path Length	14.1136
Length of Longest Path	36
Minimum Path Strength	1.07
Average Path Strength	6.11748
Maximum Path Strength	22.445
Minimum Path Correlation	0.7
Average Path Correlation	0.951917
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	68.1204
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.9624
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • response to corticotropin-releasing hormone • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to corticotropin-releasing hormone stimulus • cellular response to hormone stimulus • multicellular organismal process • system process • nitrogen compound transport • transport • signaling • hormone secretion • cell communication • peptide secretion • localization • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of biological process • secretion • corticotropin secretion • regulation of hormone levels • biological regulation • cell-cell signaling • export from cell • establishment of localization • peptide transport • endocrine hormone secretion • endocrine process • peptide hormone secretion • hormone transport • behavior • exploration behavior • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • immune response • immune system process • regulation of localization • corticosterone secretion • regulation of cellular process • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • regulation of secretion by cell • regulation of multicellular organismal process • regulation of signaling • regulation of transport • lipid localization • regulation of lipid localization • macromolecule localization • regulation of cell communication • general adaptation syndrome • response to stress • general adaptation syndrome, behavioral process • multicellular organismal response to stress • parturition • fear response • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • developmental process • multicellular organism development • adrenal gland development • endocrine system development • gland development • animal organ development • anatomical structure development • system development • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of calcium ion transport • negative regulation of voltage-gated calcium channel activity • negative regulation of ion transmembrane transporter activity • negative regulation of calcium ion transmembrane transporter activity • negative regulation of monoatomic ion transport • monoatomic ion transmembrane transport • negative regulation of biological process • regulation of transmembrane transporter activity • negative regulation of transport • regulation of monoatomic ion transmembrane transport • regulation of voltage-gated calcium channel activity • negative regulation of transmembrane transport • calcium ion transport • metal ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • negative regulation of transporter activity • negative regulation of molecular function • negative regulation of calcium ion transport • transmembrane transport • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • calcium ion transmembrane transport • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction
Gene Ontology	Cellular Component	• postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction • postsynaptic membrane • asymmetric synapse • plasma membrane region • glutamatergic synapse • cell projection • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • cytoplasm • vesicle • binding • molecular function activator activity • signaling receptor binding • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • corticotropin-releasing hormone receptor 2 binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • G protein-coupled receptor binding • hormone receptor binding • neuropeptide receptor binding • enzyme regulator activity • molecular function inhibitor activity • histone deacetylase inhibitor activity • enzyme inhibitor activity • histone deacetylase regulator activity • corticotropin-releasing hormone receptor 1 binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • regulation of growth • regulation of cellular component organization • growth • positive regulation of biological process • positive regulation of cell growth • regulation of cell growth • cell growth • cellular component organization • positive regulation of growth • cellular component organization or biogenesis • positive regulation of cellular process • multicellular organismal process • response to stress • multicellular organismal response to stress • response to pain • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of response to stimulus • negative regulation of biological process • negative regulation of appetite • regulation of response to food • regulation of response to stimulus • response to food • response to chemical • regulation of biological quality • regulation of appetite • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • aerobic respiration • cellular respiration • energy derivation by oxidation of organic compounds • metabolic process • generation of precursor metabolites and energy • interleukin-6 production • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-6 production • regulation of interleukin-6 production • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of defense response • regulation of fear response • regulation of behavioral fear response • positive regulation of response to stimulus • regulation of behavior • behavioral defense response • regulation of response to stress • behavioral fear response • defense response • positive regulation of behavioral fear response • behavior • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • positive regulation of DNA replication • regulation of primary metabolic process • nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • primary metabolic process • DNA metabolic process • nucleic acid metabolic process • DNA replication • positive regulation of DNA metabolic process • regulation of DNA metabolic process • regulation of DNA replication • regulation of localization • regulation of hormone secretion • negative regulation of signaling • transport • negative regulation of transport • hormone secretion • negative regulation of cell communication • localization • negative regulation of secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of hormone secretion • negative regulation of cellular process • negative regulation of secretion by cell • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to endogenous stimulus • response to glucocorticoid • drinking behavior • feeding behavior • positive regulation of protein metabolic process • positive regulation of translation • protein biosynthetic process • post-transcriptional regulation of gene expression • protein metabolic process • regulation of protein metabolic process • translation • regulation of translation • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • startle response • nervous system process • neuromuscular process • response to external stimulus • response to auditory stimulus • response to mechanical stimulus • response to abiotic stimulus • positive regulation of cell communication • nitrogen compound transport • regulation of system process • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • positive regulation of peptide hormone secretion • endocrine hormone secretion • regulation of endocrine process • regulation of peptide secretion • positive regulation of secretion by cell • regulation of corticotropin secretion • peptide secretion • positive regulation of hormone secretion • positive regulation of secretion • amide transport • positive regulation of peptide secretion • corticotropin secretion • regulation of peptide transport • peptide transport • endocrine process • positive regulation of transport • peptide hormone secretion • positive regulation of signaling • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • sensory perception • sensory perception of sound • sensory perception of mechanical stimulus • regulation of vascular permeability • positive regulation of vascular permeability • biological process involved in intraspecies interaction between organisms • social behavior • learning • learning or memory • cognition • associative learning • trans-synaptic signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • response to oxidative stress • negative regulation of feeding behavior • negative regulation of behavior • regulation of feeding behavior • negative regulation of multicellular organismal process • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • positive regulation of DNA-templated transcription • RNA metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • system development • negative regulation of cell size • regulation of cellular component size • regulation of cell size • heart process • regulation of heart contraction • positive regulation of blood circulation • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • positive regulation of heart contraction • regulation of blood circulation • regulation of striated muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • heart contraction • response to estradiol • response to oxygen-containing compound • regulation of blood pressure • negative regulation of blood pressure • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • main axon • varicosity • dendrite • dendritic tree • extracellular region • axon terminus • presynapse • distal axon • neuron projection terminus • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • cyclase inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • establishment of protein localization • regulation of protein localization • protein localization to extracellular region • intracellular protein localization • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • protein transport • regulation of insulin secretion • macromolecule localization • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of peptide secretion • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34998-2
Sequence	>6PB0_nogp_Chain_R L N E E K K S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L R S I R C L R N I I H W N L I S A F I L R N A T W F V V Q L T M S P E V H Q S N V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L T Y S T D R L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D N E K C W F G K R P G V Y T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V N P G E D E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E V R S A I R K R W H R W Q D K H S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4K5Y	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	2.98	2013-07-17	doi.org/10.1038/nature12357
	4Z9G	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	3.18	2016-06-29	doi.org/10.2174/1874467210666170110114727
	8GTG	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-I152	-	2.75	2023-09-13	doi.org/10.1038/s12276-023-01082-1
	8GTI	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C205	-	2.2	2023-09-13	doi.org/10.1038/s12276-023-01082-1
	8GTM	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C203	-	2.6	2023-09-13	doi.org/10.1038/s12276-023-01082-1
	6P9X	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-	Gs/β1/γ2	2.91	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6P9X (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-		2.91	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6PB0	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	3	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	6PB0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-		3	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013

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