psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E3	R:R:K262	4.05	Yes	No	0	0	5
2	L:L:E3	R:R:Y267	6.73	Yes	No	0	0	1
3	L:L:H13	L:L:P5	15.25	No	No	0	0	0
4	L:L:P5	R:R:F344	4.33	No	Yes	0	0	6
5	L:L:I6	L:L:L8	4.28	No	No	0	0	0
6	L:L:I6	R:R:Q273	5.49	No	Yes	0	0	7
7	L:L:I6	R:R:F331	6.28	No	No	0	0	5
8	L:L:S7	R:R:Y327	6.36	No	Yes	0	0	8
9	L:L:S7	R:R:N348	4.47	No	No	0	0	8
10	L:L:L8	R:R:M276	5.65	No	No	0	0	7
11	L:L:L8	R:R:Y327	4.69	No	Yes	0	0	8
12	L:L:D9	L:L:R16	4.76	No	No	0	0	0
13	L:L:D9	R:R:Q273	6.53	No	Yes	0	0	7
14	L:L:L10	R:R:S349	4.5	No	No	0	0	6
15	L:L:L10	R:R:E352	5.3	No	No	0	0	8
16	L:L:T11	R:R:W169	7.28	No	Yes	0	0	7
17	L:L:T11	R:R:Y195	11.24	No	Yes	0	0	5
18	L:L:F12	R:R:T192	6.49	Yes	No	1	0	7
19	L:L:F12	R:R:Y195	6.19	Yes	Yes	0	0	5
20	L:L:F12	R:R:N196	4.83	Yes	No	1	0	8
21	L:L:F12	R:R:F260	16.08	Yes	Yes	1	0	6
22	L:L:E17	L:L:H13	8.62	No	No	0	0	0
23	L:L:L14	R:R:N123	4.12	No	No	0	0	7
24	L:L:L15	R:R:Q173	3.99	No	No	0	0	7
25	L:L:L15	R:R:F260	8.53	No	Yes	0	0	6
26	L:L:R16	R:R:K262	8.66	No	No	0	0	5
27	L:L:E17	L:L:E20	6.34	No	No	0	0	0
28	L:L:E17	R:R:Y116	10.1	No	No	0	0	3
29	L:L:L19	R:R:H181	9	No	No	0	0	4
30	L:L:M21	R:R:K113	8.64	Yes	No	0	0	1
31	L:L:M21	R:R:H117	9.19	Yes	No	0	0	2
32	R:R:H115	R:R:Y116	17.42	No	No	0	4	3
33	R:R:H115	R:R:V342	15.22	No	No	0	4	3
34	R:R:V118	R:R:Y346	8.83	No	No	0	4	6
35	R:R:N123	R:R:W169	6.78	No	Yes	0	7	7
36	R:R:N123	R:R:S349	4.47	No	No	0	7	6
37	R:R:W169	R:R:Y124	8.68	Yes	No	2	7	6
38	R:R:Q173	R:R:Y124	9.02	No	No	2	7	6
39	R:R:F354	R:R:G126	9.03	Yes	No	0	6	8
40	R:R:H127	R:R:R165	7.9	Yes	Yes	2	7	8
41	R:R:H127	R:R:N166	6.38	Yes	Yes	2	7	7
42	R:R:H127	R:R:W169	35.97	Yes	Yes	2	7	7
43	R:R:H127	R:R:S353	4.18	Yes	No	0	7	8
44	R:R:L131	R:R:N166	4.12	No	Yes	0	6	7
45	R:R:I159	R:R:L134	5.71	No	Yes	0	7	8
46	R:R:F162	R:R:L134	6.09	Yes	Yes	0	7	8
47	R:R:I163	R:R:L134	5.71	No	Yes	0	7	8
48	R:R:L134	R:R:N166	4.12	Yes	Yes	0	8	7
49	R:R:G356	R:R:L134	5.13	No	Yes	0	9	8
50	R:R:I163	R:R:L135	5.71	No	No	0	7	3
51	R:R:F365	R:R:V136	5.24	No	No	0	6	5
52	R:R:F138	R:R:W156	11.02	No	Yes	0	6	5
53	R:R:F141	R:R:N152	8.46	No	No	0	7	8
54	R:R:F141	R:R:W156	11.02	No	Yes	0	7	5
55	R:R:C364	R:R:F141	4.19	Yes	No	0	8	7
56	R:R:L142	R:R:W156	9.11	No	Yes	0	3	5
57	R:R:I147	R:R:L144	5.71	Yes	No	0	7	6
58	R:R:L144	R:R:R377	6.07	No	No	0	6	4
59	R:R:R145	R:R:R148	8.53	No	No	0	6	7
60	R:R:E369	R:R:I147	9.56	No	Yes	0	8	7
61	R:R:C149	R:R:R151	4.18	No	Yes	7	6	8
62	R:R:C149	R:R:N152	4.72	No	No	7	6	8
63	R:R:I154	R:R:L150	4.28	Yes	No	0	8	6
64	R:R:N152	R:R:R151	10.85	No	Yes	7	8	8
65	R:R:R151	R:R:Y212	4.12	Yes	No	0	8	7
66	R:R:I153	R:R:K228	5.82	No	No	0	6	5
67	R:R:I154	R:R:W205	4.7	Yes	Yes	0	8	9
68	R:R:E209	R:R:I154	6.83	Yes	Yes	0	9	8
69	R:R:F231	R:R:I154	13.82	Yes	Yes	0	6	8
70	R:R:E209	R:R:H155	9.85	Yes	No	0	9	9
71	R:R:H155	R:R:Y363	7.62	No	Yes	0	9	8
72	R:R:N157	R:R:W205	15.82	No	Yes	8	9	9
73	R:R:I232	R:R:N157	4.25	No	No	0	4	9
74	R:R:N157	R:R:W236	6.78	No	Yes	8	9	9
75	R:R:F162	R:R:L158	8.53	Yes	No	0	7	8
76	R:R:E209	R:R:L158	11.93	Yes	No	0	9	8
77	R:R:S160	R:R:W236	4.94	No	Yes	0	3	9
78	R:R:A161	R:R:W236	3.89	No	Yes	0	8	9
79	R:R:F162	R:R:N202	12.08	Yes	No	0	7	7
80	R:R:F162	R:R:Q355	8.2	Yes	No	0	7	9
81	R:R:F162	R:R:V359	3.93	Yes	No	0	7	9
82	R:R:F198	R:R:L164	13.4	No	No	0	6	5
83	R:R:N166	R:R:R165	6.03	Yes	Yes	2	7	8
84	R:R:R165	R:R:Y195	9.26	Yes	Yes	0	8	5
85	R:R:H199	R:R:R165	5.64	No	Yes	2	5	8
86	R:R:N202	R:R:R165	10.85	No	Yes	0	7	8
87	R:R:F198	R:R:T168	6.49	No	No	0	6	4
88	R:R:F170	R:R:W169	10.02	No	Yes	0	7	7
89	R:R:Q173	R:R:W169	16.43	No	Yes	2	7	7
90	R:R:T175	R:R:W187	4.85	No	No	0	3	2
91	R:R:F260	R:R:M176	6.22	Yes	No	1	6	6
92	R:R:S177	R:R:V180	4.85	No	No	0	4	2
93	R:R:H181	R:R:K257	11.79	No	No	0	4	3
94	R:R:F260	R:R:H181	9.05	Yes	No	0	6	4
95	R:R:N184	R:R:R189	14.46	No	Yes	3	6	6
96	R:R:N184	R:R:N255	4.09	No	Yes	3	6	4
97	R:R:V185	R:R:W187	12.26	No	No	0	3	2
98	R:R:C188	R:R:C258	7.28	No	No	1	9	9
99	R:R:N255	R:R:R189	8.44	Yes	Yes	3	4	6
100	R:R:R189	R:R:W259	21.99	Yes	Yes	3	6	9
101	R:R:F260	R:R:T192	6.49	Yes	No	1	6	7
102	R:R:N196	R:R:W246	10.17	No	Yes	1	8	8
103	R:R:N196	R:R:Y272	20.93	No	Yes	1	8	7
104	R:R:F198	R:R:Y197	6.19	No	Yes	0	6	8
105	R:R:T201	R:R:Y197	8.74	No	Yes	0	7	8
106	R:R:I243	R:R:Y197	4.84	No	Yes	0	7	8
107	R:R:F203	R:R:H199	4.53	Yes	No	2	8	5
108	R:R:H199	R:R:M276	6.57	No	No	2	5	7
109	R:R:P239	R:R:V200	5.3	Yes	No	0	9	7
110	R:R:T201	R:R:W236	4.85	No	Yes	0	7	9
111	R:R:P239	R:R:T201	5.25	Yes	No	0	9	7
112	R:R:F203	R:R:M206	7.46	Yes	No	0	8	9
113	R:R:F203	R:R:M276	16.17	Yes	No	2	8	7
114	R:R:F203	R:R:L280	6.09	Yes	No	0	8	6
115	R:R:F203	R:R:Y327	15.47	Yes	Yes	0	8	8
116	R:R:F204	R:R:V238	6.55	No	No	0	5	3
117	R:R:F204	R:R:P239	5.78	No	Yes	0	5	9
118	R:R:G235	R:R:W205	8.44	No	Yes	0	8	9
119	R:R:W205	R:R:W236	14.06	Yes	Yes	8	9	9
120	R:R:M206	R:R:Q355	4.08	No	No	0	9	9
121	R:R:F207	R:R:V279	6.55	Yes	No	0	6	7
122	R:R:F207	R:R:I282	5.02	Yes	No	5	6	5
123	R:R:F207	R:R:N283	6.04	Yes	No	0	6	9
124	R:R:F207	R:R:F286	4.29	Yes	Yes	5	6	7
125	R:R:E209	R:R:L322	9.28	Yes	No	0	9	8
126	R:R:I290	R:R:L213	8.56	No	No	0	8	8
127	R:R:H214	R:R:V218	16.61	No	No	0	7	6
128	R:R:F286	R:R:H214	21.5	Yes	No	0	7	7
129	R:R:H214	R:R:N289	8.93	No	Yes	0	7	6
130	R:R:L219	R:R:T215	7.37	No	No	0	4	6
131	R:R:L226	R:R:T215	8.84	No	No	0	4	6
132	R:R:I217	R:R:I293	4.42	No	No	0	7	6
133	R:R:L219	R:R:T222	7.37	No	No	0	4	5
134	R:R:F231	R:R:L226	7.31	Yes	No	0	6	4
135	R:R:R227	R:R:W229	6	No	No	9	4	2
136	R:R:M230	R:R:R227	4.96	No	No	9	3	4
137	R:R:M230	R:R:W229	11.63	No	No	9	3	2
138	R:R:F240	R:R:P241	4.33	No	No	0	4	4
139	R:R:F240	R:R:V244	7.87	No	No	0	4	3
140	R:R:I242	R:R:P275	6.77	No	No	0	6	8
141	R:R:K250	R:R:W246	6.96	Yes	Yes	0	6	8
142	R:R:W246	R:R:Y272	7.72	Yes	Yes	1	8	7
143	R:R:D254	R:R:K250	8.3	Yes	Yes	0	5	6
144	R:R:K250	R:R:W259	11.6	Yes	Yes	0	6	9
145	R:R:K250	R:R:T268	7.51	Yes	No	0	6	4
146	R:R:D269	R:R:K250	4.15	No	Yes	0	6	6
147	R:R:L251	R:R:N255	5.49	No	Yes	3	2	4
148	R:R:L251	R:R:W259	4.56	No	Yes	3	2	9
149	R:R:D254	R:R:E256	3.9	Yes	No	6	5	3
150	R:R:D254	R:R:R263	13.1	Yes	Yes	6	5	3
151	R:R:D254	R:R:V266	8.76	Yes	No	6	5	3
152	R:R:N255	R:R:W259	7.91	Yes	Yes	3	4	9
153	R:R:E256	R:R:K257	8.1	No	No	0	3	3
154	R:R:E256	R:R:R263	10.47	No	Yes	6	3	3
155	R:R:R263	R:R:V266	10.46	Yes	No	6	3	3
156	R:R:G265	R:R:Y267	5.79	No	No	0	6	1
157	R:R:T268	R:R:V266	4.76	No	No	0	4	3
158	R:R:Y267	R:R:Y270	8.94	No	No	0	1	7
159	R:R:D269	R:R:Y272	6.9	No	Yes	1	6	7
160	R:R:D269	R:R:Q273	3.92	No	Yes	1	6	7
161	R:R:Q273	R:R:Y272	14.65	Yes	Yes	1	7	7
162	R:R:G274	R:R:P275	4.06	No	No	0	3	8
163	R:R:L280	R:R:M328	5.65	No	Yes	0	6	4
164	R:R:F286	R:R:I282	5.02	Yes	No	5	7	5
165	R:R:L323	R:R:N283	5.49	No	No	0	8	9
166	R:R:F284	R:R:M328	6.22	No	Yes	0	4	4
167	R:R:L287	R:R:L319	4.15	No	No	0	7	9
168	R:R:L287	R:R:L323	4.15	No	No	0	7	8
169	R:R:F288	R:R:N289	4.83	No	Yes	0	4	6
170	R:R:N289	R:R:R292	10.85	Yes	No	0	6	6
171	R:R:T316	R:R:V291	6.35	No	No	0	7	6
172	R:R:I293	R:R:R292	6.26	No	No	0	6	6
173	R:R:L294	R:R:L298	4.15	No	No	0	7	6
174	R:R:K311	R:R:L298	5.64	No	No	0	7	6
175	R:R:Q308	R:R:T302	8.5	Yes	No	0	5	4
176	R:R:I307	R:R:S304	4.64	No	No	0	5	3
177	R:R:F362	R:R:K314	6.2	No	No	0	8	8
178	R:R:F362	R:R:V318	20.97	No	No	0	8	6
179	R:R:L319	R:R:Y363	4.69	No	Yes	0	9	8
180	R:R:I325	R:R:L320	5.71	No	No	0	6	7
181	R:R:F358	R:R:P321	7.22	No	No	0	6	7
182	R:R:L322	R:R:Y363	21.1	No	Yes	0	8	8
183	R:R:I325	R:R:M328	4.37	No	Yes	0	6	4
184	R:R:L351	R:R:T326	10.32	No	No	0	5	8
185	R:R:E352	R:R:Y327	11.22	No	Yes	0	8	8
186	R:R:Q355	R:R:Y327	6.76	No	Yes	0	9	8
187	R:R:F347	R:R:L329	7.31	Yes	No	0	5	6
188	R:R:F330	R:R:N333	4.83	Yes	Yes	4	7	6
189	R:R:F330	R:R:F344	7.5	Yes	Yes	4	7	6
190	R:R:F330	R:R:N348	4.83	Yes	No	4	7	8
191	R:R:N333	R:R:P334	4.89	Yes	No	0	6	5
192	R:R:N333	R:R:S340	8.94	Yes	No	0	6	2
193	R:R:F344	R:R:N333	8.46	Yes	Yes	4	6	6
194	R:R:D337	R:R:V339	8.76	No	No	0	3	1
195	R:R:D337	R:R:S340	7.36	No	No	0	3	2
196	R:R:E338	R:R:V342	4.28	No	No	0	3	3
197	R:R:F344	R:R:N348	12.08	Yes	No	4	6	8
198	R:R:F347	R:R:L351	6.09	Yes	No	0	5	5
199	R:R:F350	R:R:F354	8.57	No	Yes	0	5	6
200	R:R:F354	R:R:S353	5.28	Yes	No	0	6	8
201	R:R:F357	R:R:F358	4.29	No	No	0	5	6
202	R:R:F357	R:R:V361	6.55	No	No	0	5	5
203	R:R:F365	R:R:V361	3.93	No	No	0	6	5
204	R:R:F362	R:R:Y363	15.47	No	Yes	0	8	8
205	R:R:C364	R:R:F365	5.59	Yes	No	0	8	6
206	R:R:E369	R:R:N367	5.26	No	No	0	8	9
207	R:R:N367	R:R:V370	7.39	No	No	0	9	9
208	R:R:R375	R:R:W378	7	No	No	0	5	4
209	R:R:R377	R:R:R380	5.33	No	No	0	4	5
210	R:R:H379	R:R:W378	6.35	No	No	0	3	4
211	R:R:W378	R:R:W381	7.5	No	No	0	4	3
212	R:R:R225	R:R:T222	3.88	No	No	0	4	5
213	R:R:E305	R:R:Q308	3.82	No	Yes	0	4	5
214	R:R:V172	R:R:Y195	3.79	No	Yes	0	6	5
215	R:R:F354	R:R:I129	3.77	Yes	No	0	6	5
216	R:R:F357	R:R:I129	3.77	No	No	0	5	5
217	R:R:F138	R:R:I163	3.77	No	No	0	6	7
218	R:R:F331	R:R:I277	3.77	No	No	0	5	3
219	R:R:F344	R:R:I345	3.77	Yes	No	0	6	7
220	R:R:G356	R:R:S130	3.71	No	No	0	9	9
221	R:R:A137	R:R:C364	3.61	No	Yes	0	8	8
222	R:R:P178	R:R:S177	3.56	No	No	0	2	4
223	L:L:P4	R:R:V332	3.53	No	No	0	0	5
224	R:R:I271	R:R:W246	3.52	No	Yes	0	7	8
225	R:R:E369	R:R:R151	3.49	No	Yes	0	8	8
226	R:R:G324	R:R:M206	3.49	No	No	0	9	9
227	R:R:G261	R:R:K257	3.49	No	No	0	5	3
228	R:R:E338	R:R:R341	3.49	No	No	0	3	4
229	R:R:C188	R:R:V180	3.42	No	No	0	9	2
230	R:R:H115	R:R:Y346	3.27	No	No	0	4	6
231	R:R:E336	R:R:G335	3.27	No	No	0	3	5
232	R:R:C188	R:R:M176	3.24	No	No	1	9	6
233	R:R:C258	R:R:M176	3.24	No	No	1	9	6
234	R:R:S183	R:R:V185	3.23	No	No	0	2	3
235	R:R:F330	R:R:F347	3.22	Yes	Yes	0	7	5
236	R:R:V171	R:R:V191	3.21	No	No	0	4	5
237	R:R:S301	R:R:T302	3.2	No	No	0	4	4
238	R:R:C364	R:R:L140	3.17	Yes	No	0	8	8
239	R:R:T175	R:R:V171	3.17	No	No	0	3	4
240	L:L:L14	R:R:A119	3.15	No	No	0	0	6
241	L:L:E3	L:L:P4	3.14	Yes	No	0	0	0
242	R:R:T215	R:R:T223	3.14	No	No	0	6	5
243	R:R:I234	R:R:V238	3.07	No	No	0	5	3
244	L:L:M21	L:L:V18	3.04	Yes	No	0	0	0
245	R:R:F231	R:R:G208	3.01	Yes	No	0	6	7
246	R:R:F286	R:R:G210	3.01	Yes	No	0	7	7
247	R:R:G186	R:R:R189	3	No	Yes	0	2	6
248	R:R:K297	R:R:T296	3	No	No	0	8	5
249	R:R:Y252	R:R:Y253	2.98	No	No	0	3	6
250	R:R:L287	R:R:V291	2.98	No	No	0	7	6
251	R:R:L317	R:R:V313	2.98	No	No	0	5	5
252	R:R:I307	R:R:K311	2.91	No	No	0	5	7
253	R:R:F204	R:R:P275	2.89	No	No	0	5	8
254	R:R:P264	R:R:R263	2.88	No	Yes	0	5	3
255	R:R:I129	R:R:L125	2.85	No	No	0	5	6
256	R:R:I374	R:R:L140	2.85	No	No	0	5	8
257	R:R:I282	R:R:L278	2.85	No	No	0	5	3
258	R:R:K228	R:R:L150	2.82	No	No	0	5	6
259	R:R:C128	R:R:F170	2.79	No	No	0	6	7
260	R:R:C211	R:R:F207	2.79	No	Yes	5	5	6
261	R:R:C211	R:R:F231	2.79	No	Yes	0	5	6
262	R:R:C211	R:R:F286	2.79	No	Yes	5	5	7
263	R:R:L213	R:R:L319	2.77	No	No	0	8	9
264	R:R:L298	R:R:Q308	2.66	No	Yes	0	6	5
265	R:R:A193	R:R:W246	2.59	No	Yes	0	5	8
266	R:R:A193	R:R:W259	2.59	No	Yes	0	5	9
267	R:R:A247	R:R:W259	2.59	No	Yes	0	5	9
268	R:R:R299	R:R:T296	2.59	No	No	0	5	5
269	L:L:Q29	L:L:Q30	2.56	No	No	0	0	0
270	L:L:E25	L:L:Q26	2.55	No	No	0	0	0
271	L:L:E2	L:L:E3	2.54	No	Yes	0	0	0
272	R:R:I374	R:R:R143	2.51	No	No	0	5	1
273	R:R:M295	R:R:R299	2.48	No	No	0	4	5
274	R:R:V180	R:R:W187	2.45	No	No	0	2	2
275	R:R:I122	R:R:Y346	2.42	No	No	0	7	6
276	R:R:D224	R:R:R225	2.38	No	No	0	5	4
277	R:R:Q308	R:R:R299	2.34	Yes	No	0	5	5
278	R:R:F240	R:R:Y197	2.06	No	Yes	0	4	8
279	R:R:G237	R:R:P239	2.03	No	Yes	0	6	9
280	R:R:R148	R:R:W156	2	No	Yes	0	7	5
281	R:R:A133	R:R:S360	1.71	No	No	0	6	8
282	R:R:A137	R:R:S360	1.71	No	No	0	8	8
283	R:R:G335	R:R:N333	1.7	No	Yes	0	5	6
284	R:R:A216	R:R:T223	1.68	No	No	0	7	5
285	R:R:A373	R:R:I147	1.62	No	Yes	0	7	7
286	R:R:A245	R:R:I271	1.62	No	No	0	5	7
287	R:R:A312	R:R:M295	1.61	No	No	0	7	4
288	R:R:S304	R:R:T303	1.6	No	No	0	3	4
289	R:R:A315	R:R:L294	1.58	No	No	0	8	7
290	R:R:I147	R:R:S146	1.55	Yes	No	0	7	6
291	R:R:I121	R:R:V120	1.54	No	No	0	4	4
292	R:R:I248	R:R:V244	1.54	No	No	0	4	3
293	L:L:A22	L:L:E25	1.51	No	No	0	0	0
294	L:L:L14	R:R:V120	1.49	No	No	0	0	4
295	R:R:L140	R:R:V139	1.49	No	No	0	8	3
296	R:R:L366	R:R:V361	1.49	No	No	0	5	5
297	R:R:L174	R:R:T175	1.47	No	No	0	2	3
298	R:R:I293	R:R:K297	1.45	No	No	0	6	8
299	L:L:R23	R:R:P178	1.44	No	No	0	0	2
300	R:R:E179	R:R:S177	1.44	No	No	0	1	4
301	R:R:I285	R:R:N289	1.42	No	Yes	0	3	6
302	R:R:L281	R:R:M328	1.41	No	Yes	0	4	4
303	R:R:L317	R:R:L320	1.38	No	No	0	5	7
304	L:L:L27	L:L:Q26	1.33	No	No	0	0	0
305	L:L:L27	L:L:Q30	1.33	No	No	0	0	0
306	R:R:F347	R:R:V343	1.31	Yes	No	0	5	3
307	R:R:I307	R:R:R310	1.25	No	No	0	5	5
308	R:R:K376	R:R:R380	1.24	No	No	0	5	5
309	L:L:M21	R:R:Y116	1.2	Yes	No	0	0	3
310	L:L:Q26	L:L:R23	1.17	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E3	4.115	4	0	0
2	L:L:F12	8.3975	4	1	0
3	L:L:M21	5.5175	4	0	0
4	R:R:H127	13.6075	4	2	7
5	R:R:L134	5.352	5	0	8
6	R:R:I147	4.61	4	0	7
7	R:R:R151	5.66	4	7	8
8	R:R:I154	7.4075	4	0	8
9	R:R:W156	8.2875	4	0	5
10	R:R:F162	7.766	5	0	7
11	R:R:R165	7.936	5	2	8
12	R:R:N166	5.1625	4	2	7
13	R:R:W169	14.1933	6	2	7
14	R:R:R189	11.9725	4	3	6
15	R:R:Y195	7.62	4	0	5
16	R:R:Y197	5.4575	4	0	8
17	R:R:F203	9.944	5	2	8
18	R:R:W205	10.755	4	8	9
19	R:R:F207	4.938	5	5	6
20	R:R:E209	9.4725	4	0	9
21	R:R:F231	6.7325	4	0	6
22	R:R:W236	6.904	5	8	9
23	R:R:P239	4.59	4	0	9
24	R:R:W246	6.192	5	1	8
25	R:R:K250	7.704	5	0	6
26	R:R:D254	8.515	4	6	5
27	R:R:N255	6.4825	4	3	4
28	R:R:W259	8.54	6	3	9
29	R:R:F260	9.274	5	1	6
30	R:R:R263	9.2275	4	6	3
31	R:R:Y272	12.55	4	1	7
32	R:R:Q273	7.6475	4	1	7
33	R:R:F286	7.322	5	5	7
34	R:R:N289	6.5075	4	0	6
35	R:R:Q308	4.33	4	0	5
36	R:R:Y327	8.9	5	0	8
37	R:R:M328	4.4125	4	0	4
38	R:R:F330	5.095	4	4	7
39	R:R:N333	5.764	5	4	6
40	R:R:F344	7.228	5	4	6
41	R:R:F347	4.4825	4	0	5
42	R:R:F354	6.6625	4	0	6
43	R:R:Y363	12.22	4	0	8
44	R:R:C364	4.14	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R16	R:R:K262	10.0838	8.66	No	No	0	0	5
2	L:L:D9	L:L:R16	11.24	4.76	No	No	0	0	0
3	L:L:D9	R:R:Q273	12.4583	6.53	No	Yes	0	0	7
4	L:L:I6	R:R:Q273	24.3773	5.49	No	Yes	0	0	7
5	L:L:I6	L:L:L8	26.4259	4.28	No	No	0	0	0
6	L:L:L8	R:R:Y327	24.6605	4.69	No	Yes	0	0	8
7	L:L:S7	R:R:Y327	41.3634	6.36	No	Yes	0	0	8
8	L:L:S7	R:R:N348	40.4788	4.47	No	No	0	0	8
9	R:R:F344	R:R:N348	26.0185	12.08	Yes	No	4	6	8
10	L:L:P5	R:R:F344	17.5565	4.33	No	Yes	0	0	6
11	L:L:H13	L:L:P5	16.5128	15.25	No	No	0	0	0
12	L:L:F12	R:R:N196	25.0989	4.83	Yes	No	1	0	8
13	L:L:F12	R:R:Y195	46.5973	6.19	Yes	Yes	0	0	5
14	L:L:F12	R:R:F260	28.3037	16.08	Yes	Yes	1	0	6
15	L:L:E17	L:L:H13	15.4613	8.62	No	No	0	0	0
16	L:L:E17	R:R:Y116	13.3351	10.1	No	No	0	0	3
17	R:R:H199	R:R:R165	15.5777	5.64	No	Yes	2	5	8
18	R:R:H127	R:R:R165	18.5381	7.9	Yes	Yes	2	7	8
19	R:R:H127	R:R:S353	19.0774	4.18	Yes	No	0	7	8
20	R:R:F354	R:R:S353	17.5565	5.28	Yes	No	0	6	8
21	R:R:R165	R:R:Y195	46.6206	9.26	Yes	Yes	0	8	5
22	R:R:N166	R:R:R165	11.1469	6.03	Yes	Yes	2	7	8
23	R:R:Q355	R:R:Y327	45.639	6.76	No	Yes	0	9	8
24	R:R:F162	R:R:Q355	51.7033	8.2	Yes	No	0	7	9
25	R:R:F162	R:R:L134	36.5756	6.09	Yes	Yes	0	7	8
26	R:R:I163	R:R:L134	34.7598	5.71	No	Yes	0	7	8
27	R:R:F354	R:R:I129	13.1683	3.77	Yes	No	0	6	5
28	R:R:F357	R:R:I129	10.2429	3.77	No	No	0	5	5
29	R:R:F138	R:R:I163	32.7889	3.77	No	No	0	6	7
30	R:R:F138	R:R:W156	31.8111	11.02	No	Yes	0	6	5
31	R:R:F141	R:R:W156	27.9002	11.02	No	Yes	0	7	5
32	R:R:C364	R:R:F141	12.4893	4.19	Yes	No	0	8	7
33	R:R:F141	R:R:N152	16.6912	8.46	No	No	0	7	8
34	R:R:N152	R:R:R151	14.3323	10.85	No	Yes	7	8	8
35	R:R:E369	R:R:R151	12.0431	3.49	No	Yes	0	8	8
36	R:R:F162	R:R:L158	100	8.53	Yes	No	0	7	8
37	R:R:E209	R:R:L158	99.3947	11.93	Yes	No	0	9	8
38	R:R:E209	R:R:I154	79.2388	6.83	Yes	Yes	0	9	8
39	R:R:I154	R:R:W205	33.2855	4.7	Yes	Yes	0	8	9
40	R:R:F231	R:R:I154	52.002	13.82	Yes	Yes	0	6	8
41	R:R:E209	R:R:H155	14.018	9.85	Yes	No	0	9	9
42	R:R:H155	R:R:Y363	12.7764	7.62	No	Yes	0	9	8
43	R:R:E209	R:R:L322	14.0452	9.28	Yes	No	0	9	8
44	R:R:L322	R:R:Y363	12.792	21.1	No	Yes	0	8	8
45	R:R:W205	R:R:W236	28.3348	14.06	Yes	Yes	8	9	9
46	R:R:N202	R:R:R165	36.6183	10.85	No	Yes	0	7	8
47	R:R:F162	R:R:N202	36.886	12.08	Yes	No	0	7	7
48	R:R:T201	R:R:W236	24.839	4.85	No	Yes	0	7	9
49	R:R:T201	R:R:Y197	12.113	8.74	No	Yes	0	7	8
50	R:R:F260	R:R:M176	24.0436	6.22	Yes	No	1	6	6
51	R:R:C188	R:R:M176	21.8204	3.24	No	No	1	9	6
52	R:R:C188	R:R:V180	20.8078	3.42	No	No	0	9	2
53	R:R:S177	R:R:V180	11.8375	4.85	No	No	0	4	2
54	R:R:D269	R:R:Q273	12.6212	3.92	No	Yes	1	6	7
55	R:R:D269	R:R:K250	11.9229	4.15	No	Yes	0	6	6
56	R:R:K250	R:R:W259	12.5786	11.6	Yes	Yes	0	6	9
57	R:R:F203	R:R:Y327	17.8436	15.47	Yes	Yes	0	8	8
58	R:R:P239	R:R:T201	12.113	5.25	Yes	No	0	9	7
59	R:R:F203	R:R:L280	15.6708	6.09	Yes	No	0	8	6
60	R:R:C211	R:R:F231	41.7475	2.79	No	Yes	0	5	6
61	R:R:C211	R:R:F286	34.5852	2.79	No	Yes	5	5	7
62	R:R:L319	R:R:Y363	16.0937	4.69	No	Yes	0	9	8
63	R:R:F286	R:R:H214	31.5628	21.5	Yes	No	0	7	7
64	R:R:H214	R:R:N289	29.2038	8.93	No	Yes	0	7	6
65	R:R:F231	R:R:L226	10.658	7.31	Yes	No	0	6	4
66	R:R:N289	R:R:R292	25.6072	10.85	Yes	No	0	6	6
67	R:R:I293	R:R:R292	24.3928	6.26	No	No	0	6	6
68	R:R:L280	R:R:M328	13.7387	5.65	No	Yes	0	6	4
69	R:R:I293	R:R:K297	21.9291	1.45	No	No	0	6	8
70	R:R:K297	R:R:T296	20.6914	3	No	No	0	8	5
71	R:R:R299	R:R:T296	19.446	2.59	No	No	0	5	5
72	R:R:Q308	R:R:R299	15.7135	2.34	Yes	No	0	5	5
73	R:R:L298	R:R:Q308	10.6192	2.66	No	Yes	0	6	5
74	R:R:F330	R:R:N348	13.5641	4.83	Yes	No	4	7	8
75	R:R:F203	R:R:H199	12.8502	4.53	Yes	No	2	8	5
76	R:R:H127	R:R:W169	15.1354	35.97	Yes	Yes	2	7	7
77	R:R:L134	R:R:N166	22.9262	4.12	Yes	Yes	0	8	7
78	R:R:H127	R:R:N166	11.7056	6.38	Yes	Yes	2	7	7
79	R:R:K250	R:R:W246	11.2167	6.96	Yes	Yes	0	6	8
80	R:R:N196	R:R:W246	20.2568	10.17	No	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E3	R:R:K262	4.05	0	Yes	No	0	5	0	1
L:L:E3	R:R:Y267	6.73	0	Yes	No	0	1	0	1
L:L:P5	R:R:F344	4.33	0	No	Yes	0	6	0	1
L:L:I6	R:R:Q273	5.49	0	No	Yes	0	7	0	1
L:L:I6	R:R:F331	6.28	0	No	No	0	5	0	1
L:L:S7	R:R:Y327	6.36	0	No	Yes	0	8	0	1
L:L:S7	R:R:N348	4.47	0	No	No	0	8	0	1
L:L:L8	R:R:M276	5.65	0	No	No	0	7	0	1
L:L:L8	R:R:Y327	4.69	0	No	Yes	0	8	0	1
L:L:D9	R:R:Q273	6.53	0	No	Yes	0	7	0	1
L:L:L10	R:R:S349	4.5	0	No	No	0	6	0	1
L:L:L10	R:R:E352	5.3	0	No	No	0	8	0	1
L:L:T11	R:R:W169	7.28	0	No	Yes	0	7	0	1
L:L:T11	R:R:Y195	11.24	0	No	Yes	0	5	0	1
L:L:F12	R:R:T192	6.49	1	Yes	No	0	7	0	1
L:L:F12	R:R:Y195	6.19	1	Yes	Yes	0	5	0	1
L:L:F12	R:R:N196	4.83	1	Yes	No	0	8	0	1
L:L:F12	R:R:F260	16.08	1	Yes	Yes	0	6	0	1
L:L:L14	R:R:N123	4.12	0	No	No	0	7	0	1
L:L:L15	R:R:Q173	3.99	0	No	No	0	7	0	1
L:L:L15	R:R:F260	8.53	0	No	Yes	0	6	0	1
L:L:R16	R:R:K262	8.66	0	No	No	0	5	0	1
L:L:E17	R:R:Y116	10.1	0	No	No	0	3	0	1
L:L:L19	R:R:H181	9	0	No	No	0	4	0	1
L:L:M21	R:R:K113	8.64	0	Yes	No	0	1	0	1
L:L:M21	R:R:H117	9.19	0	Yes	No	0	2	0	1
R:R:H115	R:R:Y116	17.42	0	No	No	4	3	2	1
R:R:N123	R:R:W169	6.78	0	No	Yes	7	7	1	1
R:R:N123	R:R:S349	4.47	0	No	No	7	6	1	1
R:R:W169	R:R:Y124	8.68	2	Yes	No	7	6	1	2
R:R:Q173	R:R:Y124	9.02	2	No	No	7	6	1	2
R:R:H127	R:R:R165	7.9	2	Yes	Yes	7	8	2	2
R:R:H127	R:R:W169	35.97	2	Yes	Yes	7	7	2	1
R:R:R165	R:R:Y195	9.26	2	Yes	Yes	8	5	2	1
R:R:H199	R:R:R165	5.64	2	No	Yes	5	8	2	2
R:R:F170	R:R:W169	10.02	0	No	Yes	7	7	2	1
R:R:Q173	R:R:W169	16.43	2	No	Yes	7	7	1	1
R:R:F260	R:R:M176	6.22	1	Yes	No	6	6	1	2
R:R:H181	R:R:K257	11.79	0	No	No	4	3	1	2
R:R:F260	R:R:H181	9.05	1	Yes	No	6	4	1	1
R:R:F260	R:R:T192	6.49	1	Yes	No	6	7	1	1
R:R:N196	R:R:W246	10.17	1	No	Yes	8	8	1	2
R:R:N196	R:R:Y272	20.93	1	No	Yes	8	7	1	2
R:R:F203	R:R:H199	4.53	2	Yes	No	8	5	2	2
R:R:H199	R:R:M276	6.57	2	No	No	5	7	2	1
R:R:F203	R:R:M276	16.17	2	Yes	No	8	7	2	1
R:R:F203	R:R:Y327	15.47	2	Yes	Yes	8	8	2	1
R:R:W246	R:R:Y272	7.72	1	Yes	Yes	8	7	2	2
R:R:G265	R:R:Y267	5.79	0	No	No	6	1	2	1
R:R:Y267	R:R:Y270	8.94	0	No	No	1	7	1	2
R:R:D269	R:R:Y272	6.9	1	No	Yes	6	7	2	2
R:R:D269	R:R:Q273	3.92	1	No	Yes	6	7	2	1
R:R:Q273	R:R:Y272	14.65	1	Yes	Yes	7	7	1	2
R:R:E352	R:R:Y327	11.22	0	No	Yes	8	8	1	1
R:R:Q355	R:R:Y327	6.76	0	No	Yes	9	8	2	1
R:R:F330	R:R:N333	4.83	4	Yes	Yes	7	6	2	2
R:R:F330	R:R:F344	7.5	4	Yes	Yes	7	6	2	1
R:R:F330	R:R:N348	4.83	4	Yes	No	7	8	2	1
R:R:F344	R:R:N333	8.46	4	Yes	Yes	6	6	1	2
R:R:F344	R:R:N348	12.08	4	Yes	No	6	8	1	1
R:R:V172	R:R:Y195	3.79	0	No	Yes	6	5	2	1
R:R:F331	R:R:I277	3.77	0	No	No	5	3	1	2
R:R:F344	R:R:I345	3.77	4	Yes	No	6	7	1	2
R:R:P178	R:R:S177	3.56	0	No	No	2	4	1	2
L:L:P4	R:R:V332	3.53	0	No	No	0	5	0	1
L:L:L14	R:R:A119	3.15	0	No	No	0	6	0	1
R:R:I121	R:R:V120	1.54	0	No	No	4	4	2	1
L:L:L14	R:R:V120	1.49	0	No	No	0	4	0	1
L:L:R23	R:R:P178	1.44	0	No	No	0	2	0	1
L:L:M21	R:R:Y116	1.2	0	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6P9X_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.89
Number of Linked Nodes	280
Number of Links	310
Number of Hubs	44
Number of Links mediated by Hubs	165
Number of Communities	9
Number of Nodes involved in Communities	46
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	52066
Length Of Smallest Path	3
Average Path Length	14.0523
Length of Longest Path	35
Minimum Path Strength	1.25
Average Path Strength	7.52012
Maximum Path Strength	26.2
Minimum Path Correlation	0.7
Average Path Correlation	0.94455
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	58.7916
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.345
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• corticotropin-releasing hormone receptor 2 binding • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • hormone receptor binding • neuropeptide receptor binding • corticotropin-releasing hormone activity • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide activity • neuropeptide hormone activity • corticotropin-releasing hormone receptor 1 binding • response to stimulus • response to chemical • response to xenobiotic stimulus • steroid metabolic process • lipid biosynthetic process • primary metabolic process • glucocorticoid metabolic process • glucocorticoid biosynthetic process • biosynthetic process • metabolic process • cellular process • steroid biosynthetic process • steroid hormone biosynthetic process • lipid metabolic process
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • steroid metabolic process • lipid biosynthetic process • primary metabolic process • glucocorticoid metabolic process • glucocorticoid biosynthetic process • biosynthetic process • metabolic process • cellular process • steroid biosynthetic process • steroid hormone biosynthetic process • lipid metabolic process • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • biological regulation • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • multi-multicellular organism process • multicellular organismal process • reproductive process • parturition • multi-organism reproductive process • regulation of circadian sleep/wake cycle • negative regulation of biological process • negative regulation of circadian sleep/wake cycle, REM sleep • regulation of circadian rhythm • regulation of behavior • sleep • regulation of multicellular organismal process • circadian sleep/wake cycle, sleep • rhythmic process • negative regulation of behavior • circadian sleep/wake cycle • rhythmic behavior • circadian rhythm • regulation of circadian sleep/wake cycle, REM sleep • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of circadian rhythm • behavior • circadian behavior • circadian sleep/wake cycle, REM sleep • regulation of circadian sleep/wake cycle, sleep • negative regulation of multicellular organismal process • circadian sleep/wake cycle process • cellular response to stimulus • response to ketone • response to lipid • cellular response to endogenous stimulus • response to hormone • response to steroid hormone • cellular response to ketone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • response to endogenous stimulus • cellular response to dexamethasone stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to corticosteroid stimulus • response to corticosteroid • cellular response to chemical stimulus • cellular response to lipid • response to dexamethasone • response to alcohol • response to corticosterone • response to mineralocorticoid • trans-synaptic signaling • signaling • cell-cell signaling • chemical synaptic transmission • cell communication • synaptic signaling • anterograde trans-synaptic signaling • synaptic transmission, dopaminergic • positive regulation of cell communication • regulation of localization • system process • nitrogen compound transport • regulation of system process • localization • regulation of biological quality • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • positive regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • regulation of corticotropin secretion • peptide secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of peptide secretion • regulation of signaling • secretion • regulation of transport • corticotropin secretion • regulation of peptide transport • export from cell • peptide transport • endocrine process • positive regulation of transport • peptide hormone secretion • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • response to aldosterone • cell death • hormone-mediated signaling pathway • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • signal transduction • apoptotic process • programmed cell death • corticosterone secretion • positive regulation of steroid hormone secretion • regulation of glucocorticoid secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • positive regulation of corticosteroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • positive regulation of lipid transport • lipid export from cell • glucocorticoid secretion • corticosteroid hormone secretion • regulation of corticosterone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • positive regulation of corticosterone secretion • lipid localization • positive regulation of lipid localization • regulation of lipid localization • macromolecule localization • response to ether • positive regulation of cortisol secretion • cortisol secretion • regulation of cortisol secretion • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • response to stress • multicellular organismal response to stress • response to pain • response to estrogen • female pregnancy • regulation of signaling receptor activity • regulation of transmembrane transporter activity • regulation of signal transduction • regulation of NMDA receptor activity • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of response to stimulus • regulation of neurotransmitter receptor activity • negative regulation of luteinizing hormone secretion • negative regulation of transport • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of gonadotropin secretion • gonadotropin secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of cellular process • regulation of gonadotropin secretion • regulation of defense response • regulation of fear response • regulation of behavioral fear response • positive regulation of response to stimulus • behavioral defense response • regulation of response to stress • behavioral fear response • defense response • positive regulation of behavioral fear response • fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • developmental process • multicellular organism development • tube development • anatomical structure development • animal organ development • respiratory tube development • lung development • respiratory system development • system development • digestive system process • regulation of digestive system process • digestion • positive regulation of digestive system process • head development • hypothalamus development • forebrain development • brain development • diencephalon development • nervous system development • central nervous system development • limbic system development • diterpenoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • locomotory behavior • exploration behavior • locomotory exploration behavior • response to ethanol • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • establishment of protein localization • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • establishment of protein localization to extracellular region • intracellular glucose homeostasis • protein secretion • regulation of protein secretion • cellular response to carbohydrate stimulus • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of protein localization • protein localization to extracellular region • positive regulation of protein transport • response to monosaccharide • response to carbohydrate • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • response to hexose • cellular homeostasis • regulation of cellular localization • protein transport • regulation of insulin secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • insulin secretion • adrenal gland development • endocrine system development • gland development • neuron apoptotic process • response to immobilization stress • monoamine transport • serotonin secretion • regulation of serotonin secretion • serotonin transport • cellular response to nitrogen compound • response to nitrogen compound • response to alkaloid • cellular response to cocaine • cellular response to alkaloid • response to cocaine • negative regulation of amine transport • regulation of catecholamine secretion • epinephrine secretion • catecholamine transport • epinephrine transport • regulation of epinephrine secretion • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • learning or memory • nervous system process • cognition • learning • associative learning • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • blood circulation • negative regulation of blood pressure • inflammatory response • regulation of circadian sleep/wake cycle, wakefulness • positive regulation of circadian rhythm • circadian sleep/wake cycle, wakefulness • positive regulation of circadian sleep/wake cycle, wakefulness • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • modulation of chemical synaptic transmission • long-term synaptic potentiation • regulation of synaptic plasticity • positive regulation of synaptic transmission • regulation of trans-synaptic signaling • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • glucagon secretion • negative regulation of peptide secretion • regulation of glucagon secretion • negative regulation of glucagon secretion • negative regulation of peptide hormone secretion • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • extracellular region • extracellular space • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • endomembrane system • intracellular organelle lumen
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • extracellular region • extracellular space • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cytoplasmic vesicle • neuronal dense core vesicle lumen • vesicle • neuronal dense core vesicle • vesicle lumen • dense core granule • intracellular membrane-bounded organelle • secretory granule lumen • organelle lumen • organelle • secretory granule • dense core granule lumen • secretory vesicle • cytoplasm • axon • cell projection • main axon • neuron projection • varicosity • plasma membrane bounded cell projection • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • corticotrophin-releasing factor receptor activity • amide binding • binding • peptide hormone binding • hormone binding • corticotropin-releasing hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • corticotropin-releasing hormone receptor activity • cellular response to stimulus • cellular response to nitrogen compound • response to corticotropin-releasing hormone • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to corticotropin-releasing hormone stimulus • cellular response to hormone stimulus • multicellular organismal process • system process • nitrogen compound transport • transport • signaling • hormone secretion • cell communication • peptide secretion • localization • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of biological process • secretion • corticotropin secretion • regulation of hormone levels • biological regulation • cell-cell signaling • export from cell • establishment of localization • peptide transport • endocrine hormone secretion • endocrine process • peptide hormone secretion • hormone transport • behavior • exploration behavior • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • immune response • immune system process • regulation of localization • corticosterone secretion • regulation of cellular process • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • regulation of secretion by cell • regulation of multicellular organismal process • regulation of signaling • regulation of transport • lipid localization • regulation of lipid localization • macromolecule localization • regulation of cell communication • general adaptation syndrome • response to stress • general adaptation syndrome, behavioral process • multicellular organismal response to stress • parturition • fear response • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • developmental process • multicellular organism development • adrenal gland development • endocrine system development • gland development • animal organ development • anatomical structure development • system development • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of calcium ion transport • negative regulation of voltage-gated calcium channel activity • negative regulation of ion transmembrane transporter activity • negative regulation of calcium ion transmembrane transporter activity • negative regulation of monoatomic ion transport • monoatomic ion transmembrane transport • negative regulation of biological process • regulation of transmembrane transporter activity • negative regulation of transport • regulation of monoatomic ion transmembrane transport • regulation of voltage-gated calcium channel activity • negative regulation of transmembrane transport • calcium ion transport • metal ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • negative regulation of transporter activity • negative regulation of molecular function • negative regulation of calcium ion transport • transmembrane transport • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • calcium ion transmembrane transport • postsynaptic specialization membrane • postsynaptic specialization • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • neuron to neuron synapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • glutamatergic synapse • endosome • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of metabolic process • positive regulation of cellular process • establishment of protein localization • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • intracellular protein localization • regulation of peptide hormone secretion • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • protein transport • regulation of insulin secretion • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34998-2
Sequence	>6P9X_nogp_Chain_R S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L R S I R C L R N I I H W N L I S A F I L R N A T W F V V Q L T M S P E V H Q S N V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L T Y T T D R L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D N E K C W F G K R P G V Y T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V N P G E D E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E V R S A I R K R W H R W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4K5Y	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	2.98	2013-07-17	doi.org/10.1038/nature12357
	4Z9G	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	3.18	2016-06-29	doi.org/10.2174/1874467210666170110114727
	8GTG	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-I152	-	2.75	2023-09-13	doi.org/10.1038/s12276-023-01082-1
	8GTI	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C205	-	2.2	2023-09-13	doi.org/10.1038/s12276-023-01082-1
	8GTM	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C203	-	2.6	2023-09-13	doi.org/10.1038/s12276-023-01082-1
	6P9X	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-	Gs/β1/γ2	2.91	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6P9X (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-		2.91	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6PB0	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	3	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013
	6PB0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-		3	2020-02-12	doi.org/10.1016/j.molcel.2020.01.013

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