psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E3	R:R:K262	4.05	Yes	No	0	0	5
2	L:L:E3	R:R:Y267	6.73	Yes	No	0	0	1
3	L:L:H13	L:L:P5	15.25	No	No	0	0	0
4	L:L:P5	R:R:F344	4.33	No	Yes	0	0	6
5	L:L:I6	L:L:L8	4.28	No	No	0	0	0
6	L:L:I6	R:R:Q273	5.49	No	Yes	0	0	7
7	L:L:I6	R:R:F331	6.28	No	No	0	0	5
8	L:L:S7	R:R:Y327	6.36	No	Yes	0	0	8
9	L:L:S7	R:R:N348	4.47	No	No	0	0	8
10	L:L:L8	R:R:M276	5.65	No	No	0	0	7
11	L:L:L8	R:R:Y327	4.69	No	Yes	0	0	8
12	L:L:D9	L:L:R16	4.76	No	No	0	0	0
13	L:L:D9	R:R:Q273	6.53	No	Yes	0	0	7
14	L:L:L10	R:R:S349	4.5	No	No	0	0	6
15	L:L:L10	R:R:E352	5.3	No	No	0	0	8
16	L:L:T11	R:R:W169	7.28	No	Yes	0	0	7
17	L:L:T11	R:R:Y195	11.24	No	Yes	0	0	5
18	L:L:F12	R:R:T192	6.49	Yes	No	1	0	7
19	L:L:F12	R:R:Y195	6.19	Yes	Yes	0	0	5
20	L:L:F12	R:R:N196	4.83	Yes	No	1	0	8
21	L:L:F12	R:R:F260	16.08	Yes	Yes	1	0	6
22	L:L:E17	L:L:H13	8.62	No	No	0	0	0
23	L:L:L14	R:R:N123	4.12	No	No	0	0	7
24	L:L:L15	R:R:Q173	3.99	No	No	0	0	7
25	L:L:L15	R:R:F260	8.53	No	Yes	0	0	6
26	L:L:R16	R:R:K262	8.66	No	No	0	0	5
27	L:L:E17	L:L:E20	6.34	No	No	0	0	0
28	L:L:E17	R:R:Y116	10.1	No	No	0	0	3
29	L:L:L19	R:R:H181	9	No	No	0	0	4
30	L:L:M21	R:R:K113	8.64	Yes	No	0	0	1
31	L:L:M21	R:R:H117	9.19	Yes	No	0	0	2
32	R:R:H115	R:R:Y116	17.42	No	No	0	4	3
33	R:R:H115	R:R:V342	15.22	No	No	0	4	3
34	R:R:V118	R:R:Y346	8.83	No	No	0	4	6
35	R:R:N123	R:R:W169	6.78	No	Yes	0	7	7
36	R:R:N123	R:R:S349	4.47	No	No	0	7	6
37	R:R:W169	R:R:Y124	8.68	Yes	No	2	7	6
38	R:R:Q173	R:R:Y124	9.02	No	No	2	7	6
39	R:R:F354	R:R:G126	9.03	Yes	No	0	6	8
40	R:R:H127	R:R:R165	7.9	Yes	Yes	2	7	8
41	R:R:H127	R:R:N166	6.38	Yes	Yes	2	7	7
42	R:R:H127	R:R:W169	35.97	Yes	Yes	2	7	7
43	R:R:H127	R:R:S353	4.18	Yes	No	0	7	8
44	R:R:L131	R:R:N166	4.12	No	Yes	0	6	7
45	R:R:I159	R:R:L134	5.71	No	Yes	0	7	8
46	R:R:F162	R:R:L134	6.09	Yes	Yes	0	7	8
47	R:R:I163	R:R:L134	5.71	No	Yes	0	7	8
48	R:R:L134	R:R:N166	4.12	Yes	Yes	0	8	7
49	R:R:G356	R:R:L134	5.13	No	Yes	0	9	8
50	R:R:I163	R:R:L135	5.71	No	No	0	7	3
51	R:R:F365	R:R:V136	5.24	No	No	0	6	5
52	R:R:F138	R:R:W156	11.02	No	Yes	0	6	5
53	R:R:F141	R:R:N152	8.46	No	No	0	7	8
54	R:R:F141	R:R:W156	11.02	No	Yes	0	7	5
55	R:R:C364	R:R:F141	4.19	Yes	No	0	8	7
56	R:R:L142	R:R:W156	9.11	No	Yes	0	3	5
57	R:R:I147	R:R:L144	5.71	Yes	No	0	7	6
58	R:R:L144	R:R:R377	6.07	No	No	0	6	4
59	R:R:R145	R:R:R148	8.53	No	No	0	6	7
60	R:R:E369	R:R:I147	9.56	No	Yes	0	8	7
61	R:R:C149	R:R:R151	4.18	No	Yes	7	6	8
62	R:R:C149	R:R:N152	4.72	No	No	7	6	8
63	R:R:I154	R:R:L150	4.28	Yes	No	0	8	6
64	R:R:N152	R:R:R151	10.85	No	Yes	7	8	8
65	R:R:R151	R:R:Y212	4.12	Yes	No	0	8	7
66	R:R:I153	R:R:K228	5.82	No	No	0	6	5
67	R:R:I154	R:R:W205	4.7	Yes	Yes	0	8	9
68	R:R:E209	R:R:I154	6.83	Yes	Yes	0	9	8
69	R:R:F231	R:R:I154	13.82	Yes	Yes	0	6	8
70	R:R:E209	R:R:H155	9.85	Yes	No	0	9	9
71	R:R:H155	R:R:Y363	7.62	No	Yes	0	9	8
72	R:R:N157	R:R:W205	15.82	No	Yes	8	9	9
73	R:R:I232	R:R:N157	4.25	No	No	0	4	9
74	R:R:N157	R:R:W236	6.78	No	Yes	8	9	9
75	R:R:F162	R:R:L158	8.53	Yes	No	0	7	8
76	R:R:E209	R:R:L158	11.93	Yes	No	0	9	8
77	R:R:S160	R:R:W236	4.94	No	Yes	0	3	9
78	R:R:A161	R:R:W236	3.89	No	Yes	0	8	9
79	R:R:F162	R:R:N202	12.08	Yes	No	0	7	7
80	R:R:F162	R:R:Q355	8.2	Yes	No	0	7	9
81	R:R:F162	R:R:V359	3.93	Yes	No	0	7	9
82	R:R:F198	R:R:L164	13.4	No	No	0	6	5
83	R:R:N166	R:R:R165	6.03	Yes	Yes	2	7	8
84	R:R:R165	R:R:Y195	9.26	Yes	Yes	0	8	5
85	R:R:H199	R:R:R165	5.64	No	Yes	2	5	8
86	R:R:N202	R:R:R165	10.85	No	Yes	0	7	8
87	R:R:F198	R:R:T168	6.49	No	No	0	6	4
88	R:R:F170	R:R:W169	10.02	No	Yes	0	7	7
89	R:R:Q173	R:R:W169	16.43	No	Yes	2	7	7
90	R:R:T175	R:R:W187	4.85	No	No	0	3	2
91	R:R:F260	R:R:M176	6.22	Yes	No	1	6	6
92	R:R:S177	R:R:V180	4.85	No	No	0	4	2
93	R:R:H181	R:R:K257	11.79	No	No	0	4	3
94	R:R:F260	R:R:H181	9.05	Yes	No	0	6	4
95	R:R:N184	R:R:R189	14.46	No	Yes	3	6	6
96	R:R:N184	R:R:N255	4.09	No	Yes	3	6	4
97	R:R:V185	R:R:W187	12.26	No	No	0	3	2
98	R:R:C188	R:R:C258	7.28	No	No	1	9	9
99	R:R:N255	R:R:R189	8.44	Yes	Yes	3	4	6
100	R:R:R189	R:R:W259	21.99	Yes	Yes	3	6	9
101	R:R:F260	R:R:T192	6.49	Yes	No	1	6	7
102	R:R:N196	R:R:W246	10.17	No	Yes	1	8	8
103	R:R:N196	R:R:Y272	20.93	No	Yes	1	8	7
104	R:R:F198	R:R:Y197	6.19	No	Yes	0	6	8
105	R:R:T201	R:R:Y197	8.74	No	Yes	0	7	8
106	R:R:I243	R:R:Y197	4.84	No	Yes	0	7	8
107	R:R:F203	R:R:H199	4.53	Yes	No	2	8	5
108	R:R:H199	R:R:M276	6.57	No	No	2	5	7
109	R:R:P239	R:R:V200	5.3	Yes	No	0	9	7
110	R:R:T201	R:R:W236	4.85	No	Yes	0	7	9
111	R:R:P239	R:R:T201	5.25	Yes	No	0	9	7
112	R:R:F203	R:R:M206	7.46	Yes	No	0	8	9
113	R:R:F203	R:R:M276	16.17	Yes	No	2	8	7
114	R:R:F203	R:R:L280	6.09	Yes	No	0	8	6
115	R:R:F203	R:R:Y327	15.47	Yes	Yes	0	8	8
116	R:R:F204	R:R:V238	6.55	No	No	0	5	3
117	R:R:F204	R:R:P239	5.78	No	Yes	0	5	9
118	R:R:G235	R:R:W205	8.44	No	Yes	0	8	9
119	R:R:W205	R:R:W236	14.06	Yes	Yes	8	9	9
120	R:R:M206	R:R:Q355	4.08	No	No	0	9	9
121	R:R:F207	R:R:V279	6.55	Yes	No	0	6	7
122	R:R:F207	R:R:I282	5.02	Yes	No	5	6	5
123	R:R:F207	R:R:N283	6.04	Yes	No	0	6	9
124	R:R:F207	R:R:F286	4.29	Yes	Yes	5	6	7
125	R:R:E209	R:R:L322	9.28	Yes	No	0	9	8
126	R:R:I290	R:R:L213	8.56	No	No	0	8	8
127	R:R:H214	R:R:V218	16.61	No	No	0	7	6
128	R:R:F286	R:R:H214	21.5	Yes	No	0	7	7
129	R:R:H214	R:R:N289	8.93	No	Yes	0	7	6
130	R:R:L219	R:R:T215	7.37	No	No	0	4	6
131	R:R:L226	R:R:T215	8.84	No	No	0	4	6
132	R:R:I217	R:R:I293	4.42	No	No	0	7	6
133	R:R:L219	R:R:T222	7.37	No	No	0	4	5
134	R:R:F231	R:R:L226	7.31	Yes	No	0	6	4
135	R:R:R227	R:R:W229	6	No	No	9	4	2
136	R:R:M230	R:R:R227	4.96	No	No	9	3	4
137	R:R:M230	R:R:W229	11.63	No	No	9	3	2
138	R:R:F240	R:R:P241	4.33	No	No	0	4	4
139	R:R:F240	R:R:V244	7.87	No	No	0	4	3
140	R:R:I242	R:R:P275	6.77	No	No	0	6	8
141	R:R:K250	R:R:W246	6.96	Yes	Yes	0	6	8
142	R:R:W246	R:R:Y272	7.72	Yes	Yes	1	8	7
143	R:R:D254	R:R:K250	8.3	Yes	Yes	0	5	6
144	R:R:K250	R:R:W259	11.6	Yes	Yes	0	6	9
145	R:R:K250	R:R:T268	7.51	Yes	No	0	6	4
146	R:R:D269	R:R:K250	4.15	No	Yes	0	6	6
147	R:R:L251	R:R:N255	5.49	No	Yes	3	2	4
148	R:R:L251	R:R:W259	4.56	No	Yes	3	2	9
149	R:R:D254	R:R:E256	3.9	Yes	No	6	5	3
150	R:R:D254	R:R:R263	13.1	Yes	Yes	6	5	3
151	R:R:D254	R:R:V266	8.76	Yes	No	6	5	3
152	R:R:N255	R:R:W259	7.91	Yes	Yes	3	4	9
153	R:R:E256	R:R:K257	8.1	No	No	0	3	3
154	R:R:E256	R:R:R263	10.47	No	Yes	6	3	3
155	R:R:R263	R:R:V266	10.46	Yes	No	6	3	3
156	R:R:G265	R:R:Y267	5.79	No	No	0	6	1
157	R:R:T268	R:R:V266	4.76	No	No	0	4	3
158	R:R:Y267	R:R:Y270	8.94	No	No	0	1	7
159	R:R:D269	R:R:Y272	6.9	No	Yes	1	6	7
160	R:R:D269	R:R:Q273	3.92	No	Yes	1	6	7
161	R:R:Q273	R:R:Y272	14.65	Yes	Yes	1	7	7
162	R:R:G274	R:R:P275	4.06	No	No	0	3	8
163	R:R:L280	R:R:M328	5.65	No	Yes	0	6	4
164	R:R:F286	R:R:I282	5.02	Yes	No	5	7	5
165	R:R:L323	R:R:N283	5.49	No	No	0	8	9
166	R:R:F284	R:R:M328	6.22	No	Yes	0	4	4
167	R:R:L287	R:R:L319	4.15	No	No	0	7	9
168	R:R:L287	R:R:L323	4.15	No	No	0	7	8
169	R:R:F288	R:R:N289	4.83	No	Yes	0	4	6
170	R:R:N289	R:R:R292	10.85	Yes	No	0	6	6
171	R:R:T316	R:R:V291	6.35	No	No	0	7	6
172	R:R:I293	R:R:R292	6.26	No	No	0	6	6
173	R:R:L294	R:R:L298	4.15	No	No	0	7	6
174	R:R:K311	R:R:L298	5.64	No	No	0	7	6
175	R:R:Q308	R:R:T302	8.5	Yes	No	0	5	4
176	R:R:I307	R:R:S304	4.64	No	No	0	5	3
177	R:R:F362	R:R:K314	6.2	No	No	0	8	8
178	R:R:F362	R:R:V318	20.97	No	No	0	8	6
179	R:R:L319	R:R:Y363	4.69	No	Yes	0	9	8
180	R:R:I325	R:R:L320	5.71	No	No	0	6	7
181	R:R:F358	R:R:P321	7.22	No	No	0	6	7
182	R:R:L322	R:R:Y363	21.1	No	Yes	0	8	8
183	R:R:I325	R:R:M328	4.37	No	Yes	0	6	4
184	R:R:L351	R:R:T326	10.32	No	No	0	5	8
185	R:R:E352	R:R:Y327	11.22	No	Yes	0	8	8
186	R:R:Q355	R:R:Y327	6.76	No	Yes	0	9	8
187	R:R:F347	R:R:L329	7.31	Yes	No	0	5	6
188	R:R:F330	R:R:N333	4.83	Yes	Yes	4	7	6
189	R:R:F330	R:R:F344	7.5	Yes	Yes	4	7	6
190	R:R:F330	R:R:N348	4.83	Yes	No	4	7	8
191	R:R:N333	R:R:P334	4.89	Yes	No	0	6	5
192	R:R:N333	R:R:S340	8.94	Yes	No	0	6	2
193	R:R:F344	R:R:N333	8.46	Yes	Yes	4	6	6
194	R:R:D337	R:R:V339	8.76	No	No	0	3	1
195	R:R:D337	R:R:S340	7.36	No	No	0	3	2
196	R:R:E338	R:R:V342	4.28	No	No	0	3	3
197	R:R:F344	R:R:N348	12.08	Yes	No	4	6	8
198	R:R:F347	R:R:L351	6.09	Yes	No	0	5	5
199	R:R:F350	R:R:F354	8.57	No	Yes	0	5	6
200	R:R:F354	R:R:S353	5.28	Yes	No	0	6	8
201	R:R:F357	R:R:F358	4.29	No	No	0	5	6
202	R:R:F357	R:R:V361	6.55	No	No	0	5	5
203	R:R:F365	R:R:V361	3.93	No	No	0	6	5
204	R:R:F362	R:R:Y363	15.47	No	Yes	0	8	8
205	R:R:C364	R:R:F365	5.59	Yes	No	0	8	6
206	R:R:E369	R:R:N367	5.26	No	No	0	8	9
207	R:R:N367	R:R:V370	7.39	No	No	0	9	9
208	R:R:R375	R:R:W378	7	No	No	0	5	4
209	R:R:R377	R:R:R380	5.33	No	No	0	4	5
210	R:R:H379	R:R:W378	6.35	No	No	0	3	4
211	R:R:W378	R:R:W381	7.5	No	No	0	4	3
212	R:R:R225	R:R:T222	3.88	No	No	0	4	5
213	R:R:E305	R:R:Q308	3.82	No	Yes	0	4	5
214	R:R:V172	R:R:Y195	3.79	No	Yes	0	6	5
215	R:R:F354	R:R:I129	3.77	Yes	No	0	6	5
216	R:R:F357	R:R:I129	3.77	No	No	0	5	5
217	R:R:F138	R:R:I163	3.77	No	No	0	6	7
218	R:R:F331	R:R:I277	3.77	No	No	0	5	3
219	R:R:F344	R:R:I345	3.77	Yes	No	0	6	7
220	R:R:G356	R:R:S130	3.71	No	No	0	9	9
221	R:R:A137	R:R:C364	3.61	No	Yes	0	8	8
222	R:R:P178	R:R:S177	3.56	No	No	0	2	4
223	L:L:P4	R:R:V332	3.53	No	No	0	0	5
224	R:R:I271	R:R:W246	3.52	No	Yes	0	7	8
225	R:R:E369	R:R:R151	3.49	No	Yes	0	8	8
226	R:R:G324	R:R:M206	3.49	No	No	0	9	9
227	R:R:G261	R:R:K257	3.49	No	No	0	5	3
228	R:R:E338	R:R:R341	3.49	No	No	0	3	4
229	R:R:C188	R:R:V180	3.42	No	No	0	9	2
230	R:R:H115	R:R:Y346	3.27	No	No	0	4	6
231	R:R:E336	R:R:G335	3.27	No	No	0	3	5
232	R:R:C188	R:R:M176	3.24	No	No	1	9	6
233	R:R:C258	R:R:M176	3.24	No	No	1	9	6
234	R:R:S183	R:R:V185	3.23	No	No	0	2	3
235	R:R:F330	R:R:F347	3.22	Yes	Yes	0	7	5
236	R:R:V171	R:R:V191	3.21	No	No	0	4	5
237	R:R:S301	R:R:T302	3.2	No	No	0	4	4
238	R:R:C364	R:R:L140	3.17	Yes	No	0	8	8
239	R:R:T175	R:R:V171	3.17	No	No	0	3	4
240	L:L:L14	R:R:A119	3.15	No	No	0	0	6
241	L:L:E3	L:L:P4	3.14	Yes	No	0	0	0
242	R:R:T215	R:R:T223	3.14	No	No	0	6	5
243	R:R:I234	R:R:V238	3.07	No	No	0	5	3
244	L:L:M21	L:L:V18	3.04	Yes	No	0	0	0
245	R:R:F231	R:R:G208	3.01	Yes	No	0	6	7
246	R:R:F286	R:R:G210	3.01	Yes	No	0	7	7
247	R:R:G186	R:R:R189	3	No	Yes	0	2	6
248	R:R:K297	R:R:T296	3	No	No	0	8	5
249	R:R:Y252	R:R:Y253	2.98	No	No	0	3	6
250	R:R:L287	R:R:V291	2.98	No	No	0	7	6
251	R:R:L317	R:R:V313	2.98	No	No	0	5	5
252	R:R:I307	R:R:K311	2.91	No	No	0	5	7
253	R:R:F204	R:R:P275	2.89	No	No	0	5	8
254	R:R:P264	R:R:R263	2.88	No	Yes	0	5	3
255	R:R:I129	R:R:L125	2.85	No	No	0	5	6
256	R:R:I374	R:R:L140	2.85	No	No	0	5	8
257	R:R:I282	R:R:L278	2.85	No	No	0	5	3
258	R:R:K228	R:R:L150	2.82	No	No	0	5	6
259	R:R:C128	R:R:F170	2.79	No	No	0	6	7
260	R:R:C211	R:R:F207	2.79	No	Yes	5	5	6
261	R:R:C211	R:R:F231	2.79	No	Yes	0	5	6
262	R:R:C211	R:R:F286	2.79	No	Yes	5	5	7
263	R:R:L213	R:R:L319	2.77	No	No	0	8	9
264	R:R:L298	R:R:Q308	2.66	No	Yes	0	6	5
265	R:R:A193	R:R:W246	2.59	No	Yes	0	5	8
266	R:R:A193	R:R:W259	2.59	No	Yes	0	5	9
267	R:R:A247	R:R:W259	2.59	No	Yes	0	5	9
268	R:R:R299	R:R:T296	2.59	No	No	0	5	5
269	L:L:Q29	L:L:Q30	2.56	No	No	0	0	0
270	L:L:E25	L:L:Q26	2.55	No	No	0	0	0
271	L:L:E2	L:L:E3	2.54	No	Yes	0	0	0
272	R:R:I374	R:R:R143	2.51	No	No	0	5	1
273	R:R:M295	R:R:R299	2.48	No	No	0	4	5
274	R:R:V180	R:R:W187	2.45	No	No	0	2	2
275	R:R:I122	R:R:Y346	2.42	No	No	0	7	6
276	R:R:D224	R:R:R225	2.38	No	No	0	5	4
277	R:R:Q308	R:R:R299	2.34	Yes	No	0	5	5
278	R:R:F240	R:R:Y197	2.06	No	Yes	0	4	8
279	R:R:G237	R:R:P239	2.03	No	Yes	0	6	9
280	R:R:R148	R:R:W156	2	No	Yes	0	7	5
281	R:R:A133	R:R:S360	1.71	No	No	0	6	8
282	R:R:A137	R:R:S360	1.71	No	No	0	8	8
283	R:R:G335	R:R:N333	1.7	No	Yes	0	5	6
284	R:R:A216	R:R:T223	1.68	No	No	0	7	5
285	R:R:A373	R:R:I147	1.62	No	Yes	0	7	7
286	R:R:A245	R:R:I271	1.62	No	No	0	5	7
287	R:R:A312	R:R:M295	1.61	No	No	0	7	4
288	R:R:S304	R:R:T303	1.6	No	No	0	3	4
289	R:R:A315	R:R:L294	1.58	No	No	0	8	7
290	R:R:I147	R:R:S146	1.55	Yes	No	0	7	6
291	R:R:I121	R:R:V120	1.54	No	No	0	4	4
292	R:R:I248	R:R:V244	1.54	No	No	0	4	3
293	L:L:A22	L:L:E25	1.51	No	No	0	0	0
294	L:L:L14	R:R:V120	1.49	No	No	0	0	4
295	R:R:L140	R:R:V139	1.49	No	No	0	8	3
296	R:R:L366	R:R:V361	1.49	No	No	0	5	5
297	R:R:L174	R:R:T175	1.47	No	No	0	2	3
298	R:R:I293	R:R:K297	1.45	No	No	0	6	8
299	L:L:R23	R:R:P178	1.44	No	No	0	0	2
300	R:R:E179	R:R:S177	1.44	No	No	0	1	4
301	R:R:I285	R:R:N289	1.42	No	Yes	0	3	6
302	R:R:L281	R:R:M328	1.41	No	Yes	0	4	4
303	R:R:L317	R:R:L320	1.38	No	No	0	5	7
304	L:L:L27	L:L:Q26	1.33	No	No	0	0	0
305	L:L:L27	L:L:Q30	1.33	No	No	0	0	0
306	R:R:F347	R:R:V343	1.31	Yes	No	0	5	3
307	R:R:I307	R:R:R310	1.25	No	No	0	5	5
308	R:R:K376	R:R:R380	1.24	No	No	0	5	5
309	L:L:M21	R:R:Y116	1.2	Yes	No	0	0	3
310	L:L:Q26	L:L:R23	1.17	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E3	4.115	4	0	0
2	L:L:F12	8.3975	4	1	0
3	L:L:M21	5.5175	4	0	0
4	R:R:H127	13.6075	4	2	7
5	R:R:L134	5.352	5	0	8
6	R:R:I147	4.61	4	0	7
7	R:R:R151	5.66	4	7	8
8	R:R:I154	7.4075	4	0	8
9	R:R:W156	8.2875	4	0	5
10	R:R:F162	7.766	5	0	7
11	R:R:R165	7.936	5	2	8
12	R:R:N166	5.1625	4	2	7
13	R:R:W169	14.1933	6	2	7
14	R:R:R189	11.9725	4	3	6
15	R:R:Y195	7.62	4	0	5
16	R:R:Y197	5.4575	4	0	8
17	R:R:F203	9.944	5	2	8
18	R:R:W205	10.755	4	8	9
19	R:R:F207	4.938	5	5	6
20	R:R:E209	9.4725	4	0	9
21	R:R:F231	6.7325	4	0	6
22	R:R:W236	6.904	5	8	9
23	R:R:P239	4.59	4	0	9
24	R:R:W246	6.192	5	1	8
25	R:R:K250	7.704	5	0	6
26	R:R:D254	8.515	4	6	5
27	R:R:N255	6.4825	4	3	4
28	R:R:W259	8.54	6	3	9
29	R:R:F260	9.274	5	1	6
30	R:R:R263	9.2275	4	6	3
31	R:R:Y272	12.55	4	1	7
32	R:R:Q273	7.6475	4	1	7
33	R:R:F286	7.322	5	5	7
34	R:R:N289	6.5075	4	0	6
35	R:R:Q308	4.33	4	0	5
36	R:R:Y327	8.9	5	0	8
37	R:R:M328	4.4125	4	0	4
38	R:R:F330	5.095	4	4	7
39	R:R:N333	5.764	5	4	6
40	R:R:F344	7.228	5	4	6
41	R:R:F347	4.4825	4	0	5
42	R:R:F354	6.6625	4	0	6
43	R:R:Y363	12.22	4	0	8
44	R:R:C364	4.14	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R16	R:R:K262	10.0838	8.66	No	No	0	0	5
2	L:L:D9	L:L:R16	11.24	4.76	No	No	0	0	0
3	L:L:D9	R:R:Q273	12.4583	6.53	No	Yes	0	0	7
4	L:L:I6	R:R:Q273	24.3773	5.49	No	Yes	0	0	7
5	L:L:I6	L:L:L8	26.4259	4.28	No	No	0	0	0
6	L:L:L8	R:R:Y327	24.6605	4.69	No	Yes	0	0	8
7	L:L:S7	R:R:Y327	41.3634	6.36	No	Yes	0	0	8
8	L:L:S7	R:R:N348	40.4788	4.47	No	No	0	0	8
9	R:R:F344	R:R:N348	26.0185	12.08	Yes	No	4	6	8
10	L:L:P5	R:R:F344	17.5565	4.33	No	Yes	0	0	6
11	L:L:H13	L:L:P5	16.5128	15.25	No	No	0	0	0
12	L:L:F12	R:R:N196	25.0989	4.83	Yes	No	1	0	8
13	L:L:F12	R:R:Y195	46.5973	6.19	Yes	Yes	0	0	5
14	L:L:F12	R:R:F260	28.3037	16.08	Yes	Yes	1	0	6
15	L:L:E17	L:L:H13	15.4613	8.62	No	No	0	0	0
16	L:L:E17	R:R:Y116	13.3351	10.1	No	No	0	0	3
17	R:R:H199	R:R:R165	15.5777	5.64	No	Yes	2	5	8
18	R:R:H127	R:R:R165	18.5381	7.9	Yes	Yes	2	7	8
19	R:R:H127	R:R:S353	19.0774	4.18	Yes	No	0	7	8
20	R:R:F354	R:R:S353	17.5565	5.28	Yes	No	0	6	8
21	R:R:R165	R:R:Y195	46.6206	9.26	Yes	Yes	0	8	5
22	R:R:N166	R:R:R165	11.1469	6.03	Yes	Yes	2	7	8
23	R:R:Q355	R:R:Y327	45.639	6.76	No	Yes	0	9	8
24	R:R:F162	R:R:Q355	51.7033	8.2	Yes	No	0	7	9
25	R:R:F162	R:R:L134	36.5756	6.09	Yes	Yes	0	7	8
26	R:R:I163	R:R:L134	34.7598	5.71	No	Yes	0	7	8
27	R:R:F354	R:R:I129	13.1683	3.77	Yes	No	0	6	5
28	R:R:F357	R:R:I129	10.2429	3.77	No	No	0	5	5
29	R:R:F138	R:R:I163	32.7889	3.77	No	No	0	6	7
30	R:R:F138	R:R:W156	31.8111	11.02	No	Yes	0	6	5
31	R:R:F141	R:R:W156	27.9002	11.02	No	Yes	0	7	5
32	R:R:C364	R:R:F141	12.4893	4.19	Yes	No	0	8	7
33	R:R:F141	R:R:N152	16.6912	8.46	No	No	0	7	8
34	R:R:N152	R:R:R151	14.3323	10.85	No	Yes	7	8	8
35	R:R:E369	R:R:R151	12.0431	3.49	No	Yes	0	8	8
36	R:R:F162	R:R:L158	100	8.53	Yes	No	0	7	8
37	R:R:E209	R:R:L158	99.3947	11.93	Yes	No	0	9	8
38	R:R:E209	R:R:I154	79.2388	6.83	Yes	Yes	0	9	8
39	R:R:I154	R:R:W205	33.2855	4.7	Yes	Yes	0	8	9
40	R:R:F231	R:R:I154	52.002	13.82	Yes	Yes	0	6	8
41	R:R:E209	R:R:H155	14.018	9.85	Yes	No	0	9	9
42	R:R:H155	R:R:Y363	12.7764	7.62	No	Yes	0	9	8
43	R:R:E209	R:R:L322	14.0452	9.28	Yes	No	0	9	8
44	R:R:L322	R:R:Y363	12.792	21.1	No	Yes	0	8	8
45	R:R:W205	R:R:W236	28.3348	14.06	Yes	Yes	8	9	9
46	R:R:N202	R:R:R165	36.6183	10.85	No	Yes	0	7	8
47	R:R:F162	R:R:N202	36.886	12.08	Yes	No	0	7	7
48	R:R:T201	R:R:W236	24.839	4.85	No	Yes	0	7	9
49	R:R:T201	R:R:Y197	12.113	8.74	No	Yes	0	7	8
50	R:R:F260	R:R:M176	24.0436	6.22	Yes	No	1	6	6
51	R:R:C188	R:R:M176	21.8204	3.24	No	No	1	9	6
52	R:R:C188	R:R:V180	20.8078	3.42	No	No	0	9	2
53	R:R:S177	R:R:V180	11.8375	4.85	No	No	0	4	2
54	R:R:D269	R:R:Q273	12.6212	3.92	No	Yes	1	6	7
55	R:R:D269	R:R:K250	11.9229	4.15	No	Yes	0	6	6
56	R:R:K250	R:R:W259	12.5786	11.6	Yes	Yes	0	6	9
57	R:R:F203	R:R:Y327	17.8436	15.47	Yes	Yes	0	8	8
58	R:R:P239	R:R:T201	12.113	5.25	Yes	No	0	9	7
59	R:R:F203	R:R:L280	15.6708	6.09	Yes	No	0	8	6
60	R:R:C211	R:R:F231	41.7475	2.79	No	Yes	0	5	6
61	R:R:C211	R:R:F286	34.5852	2.79	No	Yes	5	5	7
62	R:R:L319	R:R:Y363	16.0937	4.69	No	Yes	0	9	8
63	R:R:F286	R:R:H214	31.5628	21.5	Yes	No	0	7	7
64	R:R:H214	R:R:N289	29.2038	8.93	No	Yes	0	7	6
65	R:R:F231	R:R:L226	10.658	7.31	Yes	No	0	6	4
66	R:R:N289	R:R:R292	25.6072	10.85	Yes	No	0	6	6
67	R:R:I293	R:R:R292	24.3928	6.26	No	No	0	6	6
68	R:R:L280	R:R:M328	13.7387	5.65	No	Yes	0	6	4
69	R:R:I293	R:R:K297	21.9291	1.45	No	No	0	6	8
70	R:R:K297	R:R:T296	20.6914	3	No	No	0	8	5
71	R:R:R299	R:R:T296	19.446	2.59	No	No	0	5	5
72	R:R:Q308	R:R:R299	15.7135	2.34	Yes	No	0	5	5
73	R:R:L298	R:R:Q308	10.6192	2.66	No	Yes	0	6	5
74	R:R:F330	R:R:N348	13.5641	4.83	Yes	No	4	7	8
75	R:R:F203	R:R:H199	12.8502	4.53	Yes	No	2	8	5
76	R:R:H127	R:R:W169	15.1354	35.97	Yes	Yes	2	7	7
77	R:R:L134	R:R:N166	22.9262	4.12	Yes	Yes	0	8	7
78	R:R:H127	R:R:N166	11.7056	6.38	Yes	Yes	2	7	7
79	R:R:K250	R:R:W246	11.2167	6.96	Yes	Yes	0	6	8
80	R:R:N196	R:R:W246	20.2568	10.17	No	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E3	R:R:K262	4.05	0	Yes	No	0	5	0	1
L:L:E3	R:R:Y267	6.73	0	Yes	No	0	1	0	1
L:L:P5	R:R:F344	4.33	0	No	Yes	0	6	0	1
L:L:I6	R:R:Q273	5.49	0	No	Yes	0	7	0	1
L:L:I6	R:R:F331	6.28	0	No	No	0	5	0	1
L:L:S7	R:R:Y327	6.36	0	No	Yes	0	8	0	1
L:L:S7	R:R:N348	4.47	0	No	No	0	8	0	1
L:L:L8	R:R:M276	5.65	0	No	No	0	7	0	1
L:L:L8	R:R:Y327	4.69	0	No	Yes	0	8	0	1
L:L:D9	R:R:Q273	6.53	0	No	Yes	0	7	0	1
L:L:L10	R:R:S349	4.5	0	No	No	0	6	0	1
L:L:L10	R:R:E352	5.3	0	No	No	0	8	0	1
L:L:T11	R:R:W169	7.28	0	No	Yes	0	7	0	1
L:L:T11	R:R:Y195	11.24	0	No	Yes	0	5	0	1
L:L:F12	R:R:T192	6.49	1	Yes	No	0	7	0	1
L:L:F12	R:R:Y195	6.19	1	Yes	Yes	0	5	0	1
L:L:F12	R:R:N196	4.83	1	Yes	No	0	8	0	1
L:L:F12	R:R:F260	16.08	1	Yes	Yes	0	6	0	1
L:L:L14	R:R:N123	4.12	0	No	No	0	7	0	1
L:L:L15	R:R:Q173	3.99	0	No	No	0	7	0	1
L:L:L15	R:R:F260	8.53	0	No	Yes	0	6	0	1
L:L:R16	R:R:K262	8.66	0	No	No	0	5	0	1
L:L:E17	R:R:Y116	10.1	0	No	No	0	3	0	1
L:L:L19	R:R:H181	9	0	No	No	0	4	0	1
L:L:M21	R:R:K113	8.64	0	Yes	No	0	1	0	1
L:L:M21	R:R:H117	9.19	0	Yes	No	0	2	0	1
R:R:H115	R:R:Y116	17.42	0	No	No	4	3	2	1
R:R:N123	R:R:W169	6.78	0	No	Yes	7	7	1	1
R:R:N123	R:R:S349	4.47	0	No	No	7	6	1	1
R:R:W169	R:R:Y124	8.68	2	Yes	No	7	6	1	2
R:R:Q173	R:R:Y124	9.02	2	No	No	7	6	1	2
R:R:H127	R:R:R165	7.9	2	Yes	Yes	7	8	2	2
R:R:H127	R:R:W169	35.97	2	Yes	Yes	7	7	2	1
R:R:R165	R:R:Y195	9.26	2	Yes	Yes	8	5	2	1
R:R:H199	R:R:R165	5.64	2	No	Yes	5	8	2	2
R:R:F170	R:R:W169	10.02	0	No	Yes	7	7	2	1
R:R:Q173	R:R:W169	16.43	2	No	Yes	7	7	1	1
R:R:F260	R:R:M176	6.22	1	Yes	No	6	6	1	2
R:R:H181	R:R:K257	11.79	0	No	No	4	3	1	2
R:R:F260	R:R:H181	9.05	1	Yes	No	6	4	1	1
R:R:F260	R:R:T192	6.49	1	Yes	No	6	7	1	1
R:R:N196	R:R:W246	10.17	1	No	Yes	8	8	1	2
R:R:N196	R:R:Y272	20.93	1	No	Yes	8	7	1	2
R:R:F203	R:R:H199	4.53	2	Yes	No	8	5	2	2
R:R:H199	R:R:M276	6.57	2	No	No	5	7	2	1
R:R:F203	R:R:M276	16.17	2	Yes	No	8	7	2	1
R:R:F203	R:R:Y327	15.47	2	Yes	Yes	8	8	2	1
R:R:W246	R:R:Y272	7.72	1	Yes	Yes	8	7	2	2
R:R:G265	R:R:Y267	5.79	0	No	No	6	1	2	1
R:R:Y267	R:R:Y270	8.94	0	No	No	1	7	1	2
R:R:D269	R:R:Y272	6.9	1	No	Yes	6	7	2	2
R:R:D269	R:R:Q273	3.92	1	No	Yes	6	7	2	1
R:R:Q273	R:R:Y272	14.65	1	Yes	Yes	7	7	1	2
R:R:E352	R:R:Y327	11.22	0	No	Yes	8	8	1	1
R:R:Q355	R:R:Y327	6.76	0	No	Yes	9	8	2	1
R:R:F330	R:R:N333	4.83	4	Yes	Yes	7	6	2	2
R:R:F330	R:R:F344	7.5	4	Yes	Yes	7	6	2	1
R:R:F330	R:R:N348	4.83	4	Yes	No	7	8	2	1
R:R:F344	R:R:N333	8.46	4	Yes	Yes	6	6	1	2
R:R:F344	R:R:N348	12.08	4	Yes	No	6	8	1	1
R:R:V172	R:R:Y195	3.79	0	No	Yes	6	5	2	1
R:R:F331	R:R:I277	3.77	0	No	No	5	3	1	2
R:R:F344	R:R:I345	3.77	4	Yes	No	6	7	1	2
R:R:P178	R:R:S177	3.56	0	No	No	2	4	1	2
L:L:P4	R:R:V332	3.53	0	No	No	0	5	0	1
L:L:L14	R:R:A119	3.15	0	No	No	0	6	0	1
R:R:I121	R:R:V120	1.54	0	No	No	4	4	2	1
L:L:L14	R:R:V120	1.49	0	No	No	0	4	0	1
L:L:R23	R:R:P178	1.44	0	No	No	0	2	0	1
L:L:M21	R:R:Y116	1.2	0	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6P9X_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.89
Number of Linked Nodes	280
Number of Links	310
Number of Hubs	44
Number of Links mediated by Hubs	165
Number of Communities	9
Number of Nodes involved in Communities	46
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	52066
Length Of Smallest Path	3
Average Path Length	14.0523
Length of Longest Path	35
Minimum Path Strength	1.25
Average Path Strength	7.52012
Maximum Path Strength	26.2
Minimum Path Correlation	0.7
Average Path Correlation	0.944568
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	58.8085
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.345
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • corticotrophin-releasing factor receptor activity • amide binding • peptide hormone binding • hormone binding • corticotropin-releasing hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • corticotropin-releasing hormone receptor activity • response to corticotropin-releasing hormone • response to peptide hormone • cellular response to peptide hormone stimulus • cellular response to corticotropin-releasing hormone stimulus • nitrogen compound transport • transport • hormone secretion • peptide secretion • localization • secretion by cell • amide transport • signal release • regulation of biological quality • secretion • corticotropin secretion • regulation of hormone levels • export from cell • establishment of localization • peptide transport • endocrine hormone secretion • endocrine process • peptide hormone secretion • hormone transport • behavior • exploration behavior • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • immune response • immune system process • regulation of localization • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • regulation of secretion by cell • regulation of multicellular organismal process • regulation of signaling • regulation of transport • lipid localization • regulation of lipid localization • macromolecule localization • regulation of cell communication • general adaptation syndrome • response to stress • general adaptation syndrome, behavioral process • multicellular organismal response to stress • parturition • fear response • adult behavior • behavioral response to ethanol • response to ethanol • cell surface receptor signaling pathway • adrenal gland development • endocrine system development • gland development • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of calcium ion transmembrane transporter activity • regulation of calcium ion transport • negative regulation of voltage-gated calcium channel activity • negative regulation of ion transmembrane transporter activity • negative regulation of calcium ion transmembrane transporter activity • negative regulation of biological process • negative regulation of transport • regulation of voltage-gated calcium channel activity • calcium ion transport • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of cation channel activity • inorganic cation transmembrane transport • transmembrane transport • regulation of transmembrane transport • negative regulation of calcium ion transmembrane transport • negative regulation of cation channel activity • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • metal ion transport • negative regulation of transmembrane transport • regulation of transporter activity • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • regulation of metal ion transport • regulation of monoatomic ion transmembrane transporter activity • negative regulation of transporter activity • negative regulation of molecular function • negative regulation of calcium ion transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • synaptic membrane • postsynaptic density • postsynapse • neuron to neuron synapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • glutamatergic synapse • endosome • intracellular vesicle • cytoplasmic vesicle • corticotropin-releasing hormone receptor 2 binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • hormone receptor binding • neuropeptide receptor binding • corticotropin-releasing hormone activity • molecular function activator activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide activity • neuropeptide hormone activity • corticotropin-releasing hormone receptor 1 binding • response to xenobiotic stimulus • steroid metabolic process • lipid biosynthetic process • primary metabolic process • glucocorticoid metabolic process • glucocorticoid biosynthetic process • biosynthetic process • metabolic process • steroid biosynthetic process • steroid hormone biosynthetic process • lipid metabolic process • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of circadian sleep/wake cycle • negative regulation of circadian sleep/wake cycle, REM sleep • regulation of circadian rhythm • regulation of behavior • sleep • circadian sleep/wake cycle, sleep • rhythmic process • negative regulation of behavior • circadian sleep/wake cycle • rhythmic behavior • circadian rhythm • regulation of circadian sleep/wake cycle, REM sleep • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of circadian rhythm • circadian behavior • circadian sleep/wake cycle, REM sleep • regulation of circadian sleep/wake cycle, sleep • negative regulation of multicellular organismal process • circadian sleep/wake cycle process • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to dexamethasone stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • response to corticosteroid • response to dexamethasone • response to corticosterone • response to mineralocorticoid • trans-synaptic signaling • chemical synaptic transmission • anterograde trans-synaptic signaling • synaptic transmission, dopaminergic • positive regulation of cell communication • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • positive regulation of peptide hormone secretion • positive regulation of multicellular organismal process • regulation of peptide secretion • positive regulation of secretion by cell • regulation of corticotropin secretion • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of peptide secretion • regulation of peptide transport • positive regulation of transport • positive regulation of signaling • regulation of calcium ion import • positive regulation of calcium ion transport • positive regulation of calcium ion import • positive regulation of monoatomic ion transport • calcium ion import • response to aldosterone • cell death • hormone-mediated signaling pathway • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • apoptotic process • programmed cell death • positive regulation of steroid hormone secretion • positive regulation of glucocorticoid secretion • positive regulation of corticosteroid hormone secretion • positive regulation of lipid transport • positive regulation of corticosterone secretion • positive regulation of lipid localization • response to ether • positive regulation of cortisol secretion • cortisol secretion • regulation of cortisol secretion • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • response to pain • response to estrogen • regulation of signaling receptor activity • regulation of signal transduction • regulation of NMDA receptor activity • regulation of response to stimulus • regulation of neurotransmitter receptor activity • negative regulation of luteinizing hormone secretion • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of gonadotropin secretion • gonadotropin secretion • negative regulation of signaling • negative regulation of cell communication • regulation of gonadotropin secretion • regulation of defense response • regulation of fear response • regulation of behavioral fear response • positive regulation of response to stimulus • behavioral defense response • regulation of response to stress • behavioral fear response • defense response • positive regulation of behavioral fear response • positive regulation of fear response • positive regulation of behavior • positive regulation of defense response • tube development • respiratory tube development • lung development • respiratory system development • digestive system process • regulation of digestive system process • digestion • positive regulation of digestive system process • head development • hypothalamus development • forebrain development • brain development • diencephalon development • nervous system development • central nervous system development • limbic system development • diterpenoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • locomotory behavior • locomotory exploration behavior • positive regulation of cell population proliferation • regulation of cell population proliferation • protein localization • establishment of protein localization • positive regulation of establishment of protein localization • carbohydrate homeostasis • cellular macromolecule localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • establishment of protein localization to extracellular region • intracellular glucose homeostasis • protein secretion • regulation of protein secretion • cellular response to carbohydrate stimulus • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of protein localization • protein localization to extracellular region • positive regulation of protein transport • response to monosaccharide • response to carbohydrate • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • response to hexose • cellular homeostasis • protein transport • regulation of cellular localization • regulation of insulin secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • insulin secretion • neuron apoptotic process • response to immobilization stress • monoamine transport • serotonin secretion • regulation of serotonin secretion • serotonin transport • response to alkaloid • cellular response to cocaine • cellular response to alkaloid • response to cocaine • negative regulation of amine transport • regulation of catecholamine secretion • epinephrine secretion • catecholamine transport • epinephrine transport • regulation of epinephrine secretion • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • learning or memory • cognition • learning • associative learning • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • blood circulation • negative regulation of blood pressure • inflammatory response • regulation of circadian sleep/wake cycle, wakefulness • positive regulation of circadian rhythm • circadian sleep/wake cycle, wakefulness • positive regulation of circadian sleep/wake cycle, wakefulness • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • modulation of chemical synaptic transmission • long-term synaptic potentiation • regulation of synaptic plasticity • positive regulation of synaptic transmission • regulation of trans-synaptic signaling • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • glucagon secretion • negative regulation of peptide secretion • regulation of glucagon secretion • negative regulation of glucagon secretion • negative regulation of peptide hormone secretion • somatodendritic compartment • cell body • perikaryon • neuronal cell body • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular organelle lumen • neuronal dense core vesicle lumen • neuronal dense core vesicle • vesicle lumen • dense core granule • secretory granule lumen • organelle lumen • secretory granule • dense core granule lumen • secretory vesicle • axon • main axon • varicosity
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34998-2
Sequence	>6P9X_nogp_Chain_R S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L R S I R C L R N I I H W N L I S A F I L R N A T W F V V Q L T M S P E V H Q S N V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L T Y T T D R L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D N E K C W F G K R P G V Y T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L R A S T T S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V N P G E D E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E V R S A I R K R W H R W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GTM	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C203	-	2.6	2023-09-13	10.1038/s12276-023-01082-1
	8GTI	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C205	-	2.2	2023-09-13	10.1038/s12276-023-01082-1
	8GTG	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-I152	-	2.75	2023-09-13	10.1038/s12276-023-01082-1
	6PB0	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	3	2020-02-12	10.1016/j.molcel.2020.01.013
	6PB0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-		3	2020-02-12	10.1016/j.molcel.2020.01.013
	6P9X	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-	Gs/β1/γ2	2.91	2020-02-05	10.1016/j.molcel.2020.01.012
	6P9X (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-		2.91	2020-02-05	10.1016/j.molcel.2020.01.012
	4Z9G	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	3.18	2016-06-29	10.2174/1874467210666170110114727
	4K5Y	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	2.98	2013-07-17	10.1038/nature12357

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