psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E15	R:R:F16	8.16	No	No	0	4	3
2	R:R:I17	R:R:L265	2.85	No	No	0	2	2
3	R:R:I17	R:R:V269	4.61	No	No	0	2	6
4	R:R:I23	R:R:L19	2.85	No	No	0	6	5
5	R:R:L20	R:R:V269	4.47	No	No	0	5	6
6	R:R:A21	R:R:L78	3.15	No	Yes	0	5	3
7	R:R:I22	R:R:L78	2.85	No	Yes	0	5	3
8	R:R:A272	R:R:L24	3.15	No	No	0	4	5
9	R:R:L25	R:R:L75	5.54	No	No	0	7	7
10	R:R:A272	R:R:L25	3.15	No	No	0	4	7
11	R:R:F275	R:R:L25	4.87	No	No	0	6	7
12	R:R:A28	R:R:L276	3.15	No	No	0	7	5
13	R:R:A71	R:R:L29	4.73	No	No	0	7	6
14	R:R:S279	R:R:V31	6.46	No	No	0	7	5
15	R:R:G32	R:R:S279	3.71	No	No	0	8	7
16	R:R:L33	R:R:P34	3.28	No	No	0	5	5
17	R:R:D64	R:R:N36	12.12	Yes	Yes	6	9	9
18	R:R:L65	R:R:N36	5.49	No	Yes	0	7	9
19	R:R:N36	R:R:P282	8.15	Yes	No	6	9	9
20	R:R:F38	R:R:S42	7.93	Yes	No	4	6	7
21	R:R:F287	R:R:F38	4.29	Yes	Yes	4	7	6
22	R:R:F38	R:R:R294	3.21	Yes	Yes	4	6	6
23	R:R:A61	R:R:V39	3.39	No	No	0	8	8
24	R:R:F287	R:R:V39	2.62	Yes	No	0	7	8
25	R:R:K45	R:R:W41	4.64	No	No	0	4	3
26	R:R:R46	R:R:W41	6	No	No	0	5	3
27	R:R:R46	R:R:S42	2.64	No	No	0	5	7
28	R:R:R294	R:R:S42	5.27	Yes	No	4	6	7
29	R:R:A54	R:R:I43	3.25	No	Yes	0	7	7
30	R:R:I43	R:R:V57	3.07	Yes	Yes	0	7	7
31	R:R:I43	R:R:L58	7.14	Yes	No	0	7	6
32	R:R:I43	R:R:R294	6.26	Yes	Yes	0	7	6
33	R:R:L44	R:R:L58	4.15	No	No	0	3	6
34	R:R:K49	R:R:Q48	4.07	No	No	0	6	6
35	R:R:R129	R:R:V52	11.77	No	No	0	7	6
36	R:R:R129	R:R:T53	3.88	No	No	0	7	7
37	R:R:M111	R:R:M56	5.78	No	No	0	8	7
38	R:R:L293	R:R:V57	4.47	No	Yes	0	7	7
39	R:R:L138	R:R:N59	8.24	No	No	0	7	9
40	R:R:N59	R:R:W142	4.52	No	No	0	9	9
41	R:R:L107	R:R:L60	2.77	No	Yes	0	7	9
42	R:R:I108	R:R:L60	4.28	No	Yes	5	8	9
43	R:R:L60	R:R:M111	5.65	Yes	No	5	9	8
44	R:R:L60	R:R:N281	6.87	Yes	No	0	9	9
45	R:R:L60	R:R:Y285	3.52	Yes	Yes	5	9	9
46	R:R:A63	R:R:W142	2.59	No	No	0	8	9
47	R:R:D64	R:R:S104	2.94	Yes	No	0	9	9
48	R:R:D64	R:R:S278	5.89	Yes	No	0	9	9
49	R:R:D64	R:R:N281	6.73	Yes	No	0	9	9
50	R:R:D64	R:R:P282	3.22	Yes	No	6	9	9
51	R:R:A66	R:R:S100	3.42	No	No	0	6	8
52	R:R:S100	R:R:V67	4.85	No	No	0	8	6
53	R:R:F275	R:R:V67	2.62	No	No	0	6	6
54	R:R:S278	R:R:V67	6.46	No	No	0	9	6
55	R:R:T70	R:R:V96	3.17	No	No	0	6	5
56	R:R:C97	R:R:T70	6.76	No	No	0	6	6
57	R:R:F73	R:R:F85	7.5	No	Yes	0	6	7
58	R:R:C93	R:R:F73	5.59	No	No	0	5	6
59	R:R:F74	R:R:H94	6.79	No	Yes	0	6	6
60	L:L:?1	R:R:F74	18.93	Yes	No	0	0	6
61	R:R:H76	R:R:Q80	14.84	No	No	0	3	3
62	R:R:H76	R:R:S84	5.58	No	No	2	3	4
63	R:R:F85	R:R:H76	6.79	Yes	No	2	7	3
64	R:R:F77	R:R:W83	5.01	No	Yes	0	5	8
65	L:L:?1	R:R:L78	11.18	Yes	Yes	0	0	3
66	R:R:M165	R:R:T82	3.01	Yes	No	0	3	4
67	R:R:F85	R:R:W83	5.01	Yes	Yes	2	7	8
68	R:R:G86	R:R:W83	2.81	No	Yes	0	8	8
69	R:R:C90	R:R:W83	9.14	No	Yes	2	9	8
70	R:R:C168	R:R:W83	15.67	No	Yes	2	9	8
71	R:R:F85	R:R:S84	2.64	Yes	No	2	7	4
72	R:R:L87	R:R:R91	17.01	No	No	0	2	7
73	R:R:L87	R:R:V158	5.96	No	No	0	2	4
74	R:R:C90	R:R:H94	4.42	No	Yes	0	9	6
75	R:R:C168	R:R:C90	7.28	No	No	2	9	9
76	R:R:H94	R:R:V152	4.15	Yes	No	0	6	4
77	R:R:H94	R:R:R156	14.67	Yes	No	0	6	5
78	R:R:V99	R:R:Y95	3.79	Yes	No	8	5	5
79	R:R:A149	R:R:Y95	2.67	No	No	8	7	5
80	R:R:L153	R:R:Y95	10.55	No	No	0	4	5
81	R:R:S145	R:R:V99	4.85	No	Yes	0	8	5
82	R:R:F146	R:R:V99	6.55	No	Yes	0	3	5
83	R:R:A149	R:R:V99	3.39	No	Yes	8	7	5
84	R:R:M101	R:R:W234	3.49	No	Yes	1	7	9
85	L:L:?1	R:R:M101	5.27	Yes	No	1	0	7
86	R:R:S145	R:R:Y102	2.54	No	Yes	0	8	7
87	R:R:L148	R:R:Y102	10.55	No	Yes	1	4	7
88	R:R:T188	R:R:Y102	3.75	Yes	Yes	1	5	7
89	L:L:?1	R:R:Y102	4.37	Yes	Yes	1	0	7
90	R:R:A103	R:R:W142	5.19	No	No	0	6	9
91	R:R:A103	R:R:S145	3.42	No	No	0	6	8
92	R:R:P193	R:R:V105	3.53	Yes	No	0	9	8
93	R:R:T109	R:R:W106	3.64	No	No	1	7	5
94	R:R:P193	R:R:W106	6.76	Yes	No	1	9	5
95	R:R:I141	R:R:L107	4.28	No	No	0	6	7
96	R:R:I108	R:R:Y285	6.04	No	Yes	5	8	9
97	R:R:P193	R:R:T109	5.25	Yes	No	1	9	7
98	R:R:I196	R:R:T109	4.56	No	No	0	6	7
99	R:R:M111	R:R:Y285	3.59	No	Yes	5	8	9
100	R:R:S112	R:R:V197	8.08	No	No	0	9	8
101	R:R:S112	R:R:S200	3.26	No	No	0	9	6
102	R:R:S112	R:R:Y201	3.82	No	Yes	0	9	8
103	R:R:I196	R:R:L113	4.28	No	No	0	6	6
104	R:R:D114	R:R:R129	8.34	No	No	0	8	7
105	R:R:R115	R:R:Y201	7.2	No	Yes	0	9	8
106	R:R:R115	R:R:Y285	8.23	No	Yes	0	9	9
107	R:R:S116	R:R:S200	6.52	No	No	0	8	6
108	R:R:I204	R:R:S116	3.1	No	No	0	8	8
109	R:R:L117	R:R:S125	3	No	No	0	5	5
110	R:R:A120	R:R:R207	2.77	No	Yes	0	7	5
111	R:R:R121	R:R:V124	2.62	No	No	0	7	5
112	R:R:F123	R:R:Q126	3.51	No	No	0	5	5
113	R:R:K131	R:R:R135	3.71	No	No	0	4	4
114	R:R:L144	R:R:L148	6.92	No	No	0	4	4
115	R:R:L148	R:R:T188	2.95	No	Yes	1	4	5
116	R:R:P151	R:R:T150	3.5	No	No	0	8	4
117	R:R:H181	R:R:P151	3.05	Yes	No	0	5	8
118	L:L:?1	R:R:V152	2.78	Yes	No	0	0	4
119	R:R:Y155	R:R:Y172	16.88	No	Yes	3	4	4
120	R:R:H177	R:R:Y155	6.53	No	No	0	2	4
121	R:R:H181	R:R:Y155	4.36	Yes	No	3	5	4
122	R:R:F169	R:R:R156	4.28	Yes	No	3	3	5
123	R:R:P170	R:R:R156	15.85	No	No	3	4	5
124	R:R:R171	R:R:T157	2.59	No	No	0	4	4
125	R:R:C168	R:R:V158	3.42	No	No	0	9	4
126	R:R:P160	R:R:V159	3.53	No	No	0	1	3
127	R:R:F169	R:R:V159	6.55	Yes	No	0	3	3
128	R:R:K162	R:R:W161	11.6	No	No	7	1	2
129	R:R:M165	R:R:W161	3.49	Yes	No	7	3	2
130	R:R:L167	R:R:W161	4.56	No	No	0	3	2
131	R:R:K162	R:R:M165	2.88	No	Yes	7	1	3
132	R:R:N164	R:R:T163	2.92	No	No	0	5	3
133	R:R:F169	R:R:P170	4.33	Yes	No	3	3	4
134	R:R:P170	R:R:Y172	8.34	No	Yes	3	4	4
135	R:R:R178	R:R:Y172	13.38	No	Yes	0	4	4
136	R:R:H181	R:R:Y172	11.98	Yes	Yes	3	5	4
137	R:R:H177	R:R:P173	4.58	No	No	0	2	4
138	R:R:E175	R:R:R178	5.82	No	No	0	3	4
139	R:R:A254	R:R:R178	4.15	No	No	0	2	4
140	R:R:A179	R:R:L249	4.73	No	No	0	3	2
141	R:R:E185	R:R:H181	7.39	No	Yes	0	5	5
142	R:R:L182	R:R:N241	2.75	No	No	0	4	6
143	R:R:E244	R:R:L182	2.65	Yes	No	0	3	4
144	R:R:A245	R:R:L182	3.15	No	No	0	4	4
145	R:R:F184	R:R:T188	7.78	No	Yes	0	3	5
146	R:R:E185	R:R:N241	2.63	No	No	0	5	6
147	L:L:?1	R:R:E185	8.24	Yes	No	0	0	5
148	R:R:A186	R:R:L242	3.15	No	No	0	5	5
149	R:R:T188	R:R:V187	3.17	Yes	No	0	5	5
150	R:R:F190	R:R:F194	6.43	Yes	Yes	1	8	6
151	R:R:F190	R:R:F230	4.29	Yes	No	1	8	9
152	R:R:F190	R:R:L235	3.65	Yes	No	0	8	6
153	R:R:F190	R:R:H238	9.05	Yes	Yes	0	8	8
154	R:R:F194	R:R:V198	3.93	Yes	No	0	6	5
155	R:R:F194	R:R:F230	5.36	Yes	No	1	6	9
156	R:R:A231	R:R:F194	2.77	No	Yes	0	5	6
157	R:R:I227	R:R:V198	3.07	No	No	0	8	5
158	R:R:V223	R:R:Y201	8.83	No	Yes	0	7	8
159	R:R:I226	R:R:Y201	3.63	No	Yes	0	7	8
160	R:R:D203	R:R:R206	4.76	No	No	9	3	5
161	R:R:D203	R:R:R207	13.1	No	Yes	9	3	5
162	R:R:G205	R:R:I204	3.53	No	No	0	5	8
163	R:R:I204	R:R:L208	2.85	No	No	0	8	8
164	R:R:R206	R:R:R207	6.4	No	Yes	9	5	5
165	R:R:Q209	R:R:R215	3.5	No	No	0	5	5
166	R:R:F213	R:R:R211	6.41	No	No	0	4	5
167	R:R:F213	R:R:R215	4.28	No	No	0	4	5
168	R:R:R217	R:R:R218	21.32	No	No	0	5	7
169	R:R:R217	R:R:T219	2.59	No	No	0	5	7
170	R:R:G290	R:R:R218	4.5	Yes	No	0	4	7
171	R:R:A288	R:R:L222	3.15	No	No	0	5	7
172	R:R:L228	R:R:V224	2.98	No	No	0	5	5
173	R:R:I226	R:R:L284	5.71	No	Yes	0	7	8
174	R:R:I226	R:R:Y285	4.84	No	Yes	0	7	9
175	R:R:F233	R:R:T229	2.59	No	No	0	7	6
176	R:R:L284	R:R:T229	2.95	Yes	No	0	8	6
177	R:R:F230	R:R:W234	5.01	No	Yes	1	9	9
178	R:R:F233	R:R:S277	5.28	No	No	0	7	9
179	R:R:F233	R:R:V280	2.62	No	No	0	7	6
180	R:R:H238	R:R:W234	3.17	Yes	Yes	0	8	9
181	R:R:A274	R:R:W234	5.19	No	Yes	0	8	9
182	R:R:S277	R:R:W234	7.41	No	Yes	0	9	9
183	L:L:?1	R:R:W234	3.54	Yes	Yes	1	0	9
184	R:R:L235	R:R:P236	3.28	No	No	0	6	9
185	R:R:L235	R:R:V239	2.98	No	No	0	6	6
186	R:R:L270	R:R:P236	3.28	No	No	0	7	9
187	R:R:H238	R:R:Y237	5.44	Yes	Yes	0	8	6
188	R:R:N241	R:R:Y237	15.12	No	Yes	0	6	6
189	R:R:R267	R:R:Y237	6.17	No	Yes	0	4	6
190	R:R:I271	R:R:Y237	4.84	No	Yes	0	5	6
191	R:R:E244	R:R:V240	2.85	Yes	No	10	3	4
192	R:R:R267	R:R:V240	2.62	No	No	10	4	4
193	R:R:L270	R:R:V240	2.98	No	No	0	7	4
194	R:R:A243	R:R:L263	3.15	No	No	0	4	5
195	R:R:E244	R:R:L263	3.98	Yes	No	0	3	5
196	R:R:E244	R:R:R267	3.49	Yes	No	10	3	4
197	R:R:Q252	R:R:R247	14.02	No	Yes	0	3	2
198	R:R:R247	R:R:V259	7.85	Yes	No	0	2	2
199	R:R:G260	R:R:R247	3	No	Yes	0	3	2
200	R:R:L256	R:R:Q252	3.99	No	No	0	4	3
201	R:R:A253	R:R:L256	3.15	No	No	0	3	4
202	L:L:?1	R:R:N268	6.83	Yes	No	0	0	4
203	L:L:?1	R:R:I271	6.21	Yes	No	0	0	5
204	L:L:?1	R:R:F275	3.03	Yes	No	0	0	6
205	R:R:F287	R:R:R294	5.34	Yes	Yes	4	7	6
206	R:R:F287	R:R:V298	2.62	Yes	No	0	7	5
207	R:R:L292	R:R:S295	6.01	No	No	0	6	3
208	R:R:L293	R:R:R294	6.07	No	Yes	0	7	6
209	R:R:F77	R:R:L167	2.44	No	No	0	5	3
210	R:R:F169	R:R:L167	2.44	Yes	No	0	3	3
211	R:R:F190	R:R:L191	2.44	Yes	No	0	8	4
212	R:R:L55	R:R:R50	2.43	No	No	0	6	6
213	R:R:L208	R:R:R215	2.43	No	No	0	8	5
214	R:R:L263	R:R:R247	2.43	No	Yes	0	5	2
215	R:R:F300	R:R:F38	2.14	No	Yes	0	5	6
216	L:L:?1	R:R:G98	2.13	Yes	No	0	0	4
217	R:R:R218	R:R:R221	2.13	No	No	0	7	6
218	R:R:G255	R:R:G260	2.11	No	No	0	2	3
219	R:R:G289	R:R:G290	2.11	No	Yes	0	7	4
220	R:R:G290	R:R:G291	2.11	Yes	No	0	4	6
221	R:R:G35	R:R:P34	2.03	No	No	0	7	5
222	R:R:C97	R:R:G98	1.96	No	No	0	6	4
223	R:R:A88	R:R:G89	1.95	No	No	0	1	5
224	R:R:A139	R:R:G140	1.95	No	No	0	4	3
225	R:R:A296	R:R:G297	1.95	No	No	0	5	4
226	R:R:W106	R:R:Y102	1.93	No	Yes	1	5	7
227	R:R:A71	R:R:P72	1.87	No	No	0	7	9
228	R:R:G176	R:R:S174	1.86	No	No	0	3	4
229	R:R:G289	R:R:S295	1.86	No	No	0	7	3
230	R:R:G140	R:R:V143	1.84	No	No	0	3	4
231	R:R:P282	R:R:V39	1.77	No	No	0	9	8
232	R:R:A28	R:R:S279	1.71	No	No	0	7	7
233	R:R:G32	R:R:L68	1.71	No	No	0	8	5
234	R:R:G290	R:R:L222	1.71	Yes	No	0	4	7
235	R:R:G32	R:R:N36	1.7	No	Yes	0	8	9
236	R:R:A61	R:R:V40	1.7	No	No	0	8	7
237	R:R:A286	R:R:V57	1.7	No	Yes	0	6	7
238	R:R:L192	R:R:P193	1.64	No	Yes	0	5	9
239	R:R:A110	R:R:I141	1.62	No	No	0	6	6
240	R:R:A245	R:R:I183	1.62	No	No	0	4	4
241	R:R:A54	R:R:M47	1.61	No	No	0	7	6
242	R:R:V27	R:R:V31	1.6	No	No	0	5	5
243	R:R:S166	R:R:T82	1.6	No	No	0	4	4
244	R:R:T53	R:R:V57	1.59	No	Yes	0	7	7
245	R:R:T157	R:R:V159	1.59	No	No	0	4	3
246	R:R:G189	R:R:H238	1.59	No	Yes	0	5	8
247	R:R:A71	R:R:L75	1.58	No	No	0	7	7
248	R:R:I22	R:R:S26	1.55	No	No	0	5	5
249	R:R:I23	R:R:V27	1.54	No	No	0	6	5
250	R:R:I141	R:R:V137	1.54	No	No	0	6	5
251	R:R:M133	R:R:T130	1.51	No	No	0	3	6
252	R:R:A248	R:R:E175	1.51	No	No	0	3	3
253	R:R:L78	R:R:S18	1.5	Yes	No	0	3	4
254	R:R:K131	R:R:T130	1.5	No	No	0	4	6
255	R:R:L24	R:R:V269	1.49	No	No	0	5	6
256	R:R:L62	R:R:V40	1.49	No	No	0	5	7
257	R:R:L128	R:R:V124	1.49	No	No	0	4	5
258	R:R:A186	R:R:H238	1.46	No	Yes	0	5	8
259	R:R:P122	R:R:R121	1.44	No	No	0	8	7
260	R:R:F123	R:R:P122	1.44	No	No	0	5	8
261	R:R:E175	R:R:S174	1.44	No	No	0	3	4
262	R:R:E244	R:R:S264	1.44	Yes	No	0	3	3
263	R:R:K131	R:R:L55	1.41	No	No	0	4	6
264	R:R:K127	R:R:L128	1.41	No	No	0	4	4
265	R:R:L128	R:R:M133	1.41	No	No	0	4	3
266	R:R:M165	R:R:N164	1.4	Yes	No	0	3	5
267	R:R:L24	R:R:L273	1.38	No	No	0	5	8
268	R:R:L33	R:R:L65	1.38	No	No	0	5	7
269	R:R:A54	R:R:R50	1.38	No	No	0	7	6
270	R:R:L138	R:R:L55	1.38	No	No	0	7	6
271	R:R:L222	R:R:L284	1.38	No	Yes	0	7	8
272	R:R:L225	R:R:L284	1.38	No	Yes	0	5	8
273	R:R:L273	R:R:L276	1.38	No	No	0	8	5
274	R:R:R207	R:R:V119	1.31	Yes	No	0	5	8
275	R:R:L258	R:R:R262	1.21	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N36	6.865	4	6	9
2	R:R:F38	4.3925	4	4	6
3	R:R:I43	4.93	4	0	7
4	R:R:V57	2.7075	4	0	7
5	R:R:L60	4.618	5	5	9
6	R:R:D64	6.18	5	6	9
7	R:R:L78	4.67	4	0	3
8	R:R:W83	7.528	5	2	8
9	R:R:F85	5.485	4	2	7
10	R:R:H94	7.5075	4	0	6
11	R:R:V99	4.645	4	8	5
12	R:R:Y102	4.628	5	1	7
13	R:R:M165	2.695	4	7	3
14	R:R:F169	4.4	4	3	3
15	R:R:Y172	12.645	4	3	4
16	R:R:H181	6.695	4	3	5
17	R:R:T188	4.4125	4	1	5
18	R:R:F190	5.172	5	1	8
19	R:R:P193	4.295	4	1	9
20	R:R:F194	4.6225	4	1	6
21	R:R:Y201	5.87	4	0	8
22	R:R:R207	5.895	4	9	5
23	R:R:W234	4.635	6	1	9
24	R:R:Y237	7.8925	4	0	6
25	R:R:H238	4.142	5	0	8
26	R:R:E244	2.882	5	10	3
27	R:R:R247	6.825	4	0	2
28	R:R:L284	2.855	4	0	8
29	R:R:Y285	5.244	5	5	9
30	R:R:F287	3.7175	4	4	7
31	R:R:G290	2.6075	4	0	4
32	R:R:R294	5.23	5	4	6
33	L:L:?1	6.59182	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L24	R:R:V269	10.5534	1.49	No	No	0	5	6
2	L:L:?1	R:R:L78	10.6857	11.18	Yes	Yes	0	0	3
3	L:L:?1	R:R:F275	100	3.03	Yes	No	0	0	6
4	R:R:F275	R:R:L25	29.0995	4.87	No	No	0	6	7
5	R:R:A272	R:R:L25	18.087	3.15	No	No	0	4	7
6	R:R:A272	R:R:L24	15.8689	3.15	No	No	0	4	5
7	R:R:G32	R:R:S279	15.1763	3.71	No	No	0	8	7
8	R:R:G32	R:R:N36	19.4568	1.7	No	Yes	0	8	9
9	R:R:D64	R:R:S278	81.376	5.89	Yes	No	0	9	9
10	R:R:S278	R:R:V67	81.9052	6.46	No	No	0	9	6
11	R:R:F275	R:R:V67	84.3334	2.62	No	No	0	6	6
12	R:R:D64	R:R:P282	63.9972	3.22	Yes	No	6	9	9
13	R:R:F287	R:R:F38	11.8141	4.29	Yes	Yes	4	7	6
14	R:R:F287	R:R:V39	63.0166	2.62	Yes	No	0	7	8
15	R:R:P282	R:R:V39	69.5618	1.77	No	No	0	9	8
16	R:R:F287	R:R:R294	48.2061	5.34	Yes	Yes	4	7	6
17	R:R:R46	R:R:S42	13.0205	2.64	No	No	0	5	7
18	R:R:A54	R:R:I43	12.7403	3.25	No	Yes	0	7	7
19	R:R:I43	R:R:R294	27.0916	6.26	Yes	Yes	0	7	6
20	R:R:I43	R:R:V57	13.5497	3.07	Yes	Yes	0	7	7
21	R:R:L293	R:R:R294	13.6898	6.07	No	Yes	0	7	6
22	R:R:L293	R:R:V57	11.6507	4.47	No	Yes	0	7	7
23	R:R:T53	R:R:V57	16.4916	1.59	No	Yes	0	7	7
24	R:R:R129	R:R:T53	12.2655	3.88	No	No	0	7	7
25	R:R:D64	R:R:N281	43.4275	6.73	Yes	No	0	9	9
26	R:R:L60	R:R:N281	41.9177	6.87	Yes	No	0	9	9
27	L:L:?1	R:R:Y102	62.355	4.37	Yes	Yes	1	0	7
28	R:R:S145	R:R:Y102	41.9332	2.54	No	Yes	0	8	7
29	R:R:A103	R:R:S145	32.4539	3.42	No	No	0	6	8
30	R:R:A103	R:R:W142	30.8662	5.19	No	No	0	6	9
31	R:R:N59	R:R:W142	27.7687	4.52	No	No	0	9	9
32	R:R:L138	R:R:N59	26.3055	8.24	No	No	0	7	9
33	R:R:L60	R:R:Y285	29.7144	3.52	Yes	Yes	5	9	9
34	R:R:F85	R:R:W83	22.9201	5.01	Yes	Yes	2	7	8
35	R:R:C90	R:R:W83	31.9013	9.14	No	Yes	2	9	8
36	R:R:C90	R:R:H94	49.2957	4.42	No	Yes	0	9	6
37	R:R:F74	R:R:H94	47.6691	6.79	No	Yes	0	6	6
38	L:L:?1	R:R:F74	48.961	18.93	Yes	No	0	0	6
39	R:R:H94	R:R:V152	47.887	4.15	Yes	No	0	6	4
40	L:L:?1	R:R:V152	49.1478	2.78	Yes	No	0	0	4
41	R:R:H94	R:R:R156	46.4939	14.67	Yes	No	0	6	5
42	R:R:F169	R:R:R156	38.8435	4.28	Yes	No	3	3	5
43	R:R:F169	R:R:L167	27.9477	2.44	Yes	No	0	3	3
44	R:R:L167	R:R:W161	23.854	4.56	No	No	0	3	2
45	R:R:M165	R:R:W161	17.0753	3.49	Yes	No	7	3	2
46	R:R:C168	R:R:C90	14.3747	7.28	No	No	2	9	9
47	R:R:C168	R:R:V158	11.3161	3.42	No	No	0	9	4
48	R:R:S145	R:R:V99	10.888	4.85	No	Yes	0	8	5
49	L:L:?1	R:R:W234	69.3206	3.54	Yes	Yes	1	0	9
50	R:R:W106	R:R:Y102	15.1918	1.93	No	Yes	1	5	7
51	R:R:R115	R:R:Y285	11.713	8.23	No	Yes	0	9	9
52	R:R:R115	R:R:Y201	10.3743	7.2	No	Yes	0	9	8
53	R:R:S112	R:R:Y201	31.9636	3.82	No	Yes	0	9	8
54	R:R:I226	R:R:Y285	22.2274	4.84	No	Yes	0	7	9
55	R:R:I226	R:R:Y201	29.3252	3.63	No	Yes	0	7	8
56	R:R:S277	R:R:W234	49.5447	7.41	No	Yes	0	9	9
57	R:R:F233	R:R:S277	47.9804	5.28	No	No	0	7	9
58	R:R:F233	R:R:T229	45.5677	2.59	No	No	0	7	6
59	R:R:L284	R:R:T229	44.7428	2.95	Yes	No	0	8	6
60	R:R:I226	R:R:L284	33.9715	5.71	No	Yes	0	7	8
61	R:R:S112	R:R:S200	26.2355	3.26	No	No	0	9	6
62	R:R:S116	R:R:S200	23.3481	6.52	No	No	0	8	6
63	R:R:I204	R:R:S116	20.4452	3.1	No	No	0	8	8
64	R:R:L138	R:R:L55	25.0992	1.38	No	No	0	7	6
65	R:R:K131	R:R:L55	23.6283	1.41	No	No	0	4	6
66	R:R:K131	R:R:T130	19.6358	1.5	No	No	0	4	6
67	R:R:M133	R:R:T130	17.4877	1.51	No	No	0	3	6
68	R:R:L128	R:R:M133	15.3242	1.41	No	No	0	4	3
69	R:R:L128	R:R:V124	11.1993	1.49	No	No	0	4	5
70	L:L:?1	R:R:E185	41.7075	8.24	Yes	No	0	0	5
71	R:R:E185	R:R:H181	26.2744	7.39	No	Yes	0	5	5
72	R:R:H181	R:R:Y172	16.764	11.98	Yes	Yes	3	5	4
73	R:R:F169	R:R:V159	13.8454	6.55	Yes	No	0	3	3
74	R:R:R178	R:R:Y172	12.2422	13.38	No	Yes	0	4	4
75	R:R:E185	R:R:N241	25.8853	2.63	No	No	0	5	6
76	R:R:L182	R:R:N241	23.4337	2.75	No	No	0	4	6
77	R:R:E244	R:R:L182	17.1998	2.65	Yes	No	0	3	4
78	R:R:E244	R:R:R267	18.3049	3.49	Yes	No	10	3	4
79	R:R:R267	R:R:Y237	24.3832	6.17	No	Yes	0	4	6
80	R:R:I271	R:R:Y237	19.6124	4.84	No	Yes	0	5	6
81	L:L:?1	R:R:I271	21.2779	6.21	Yes	No	0	0	5
82	R:R:H238	R:R:W234	23.3014	3.17	Yes	Yes	0	8	9
83	R:R:F190	R:R:F230	10.063	4.29	Yes	No	1	8	9
84	R:R:F230	R:R:W234	19.6124	5.01	No	Yes	1	9	9
85	R:R:F190	R:R:H238	11.9231	9.05	Yes	Yes	0	8	8
86	R:R:F190	R:R:L235	12.9349	3.65	Yes	No	0	8	6
87	R:R:I204	R:R:L208	14.5926	2.85	No	No	0	8	8
88	R:R:L208	R:R:R215	11.6351	2.43	No	No	0	8	5
89	R:R:L222	R:R:L284	23.3403	1.38	No	Yes	0	7	8
90	R:R:G290	R:R:L222	19.3167	1.71	Yes	No	0	4	7
91	R:R:E244	R:R:L263	29.2708	3.98	Yes	No	0	3	5
92	R:R:L263	R:R:R247	22.8734	2.43	No	Yes	0	5	2
93	R:R:L55	R:R:R50	14.4992	2.43	No	No	0	6	6
94	R:R:D64	R:R:N36	22.78	12.12	Yes	Yes	6	9	9
95	R:R:A54	R:R:R50	13.7676	1.38	No	No	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:A21	R:R:L78	3.15	0	No	Yes	5	3	2	1
R:R:I22	R:R:L78	2.85	0	No	Yes	5	3	2	1
R:R:F275	R:R:L25	4.87	0	No	No	6	7	1	2
R:R:F275	R:R:V67	2.62	0	No	No	6	6	1	2
R:R:F74	R:R:H94	6.79	0	No	Yes	6	6	1	2
L:L:?1	R:R:F74	18.93	1	Yes	No	0	6	0	1
L:L:?1	R:R:L78	11.18	1	Yes	Yes	0	3	0	1
R:R:H94	R:R:V152	4.15	0	Yes	No	6	4	2	1
R:R:M101	R:R:W234	3.49	1	No	Yes	7	9	1	1
L:L:?1	R:R:M101	5.27	1	Yes	No	0	7	0	1
R:R:S145	R:R:Y102	2.54	0	No	Yes	8	7	2	1
R:R:L148	R:R:Y102	10.55	1	No	Yes	4	7	2	1
R:R:T188	R:R:Y102	3.75	1	Yes	Yes	5	7	2	1
L:L:?1	R:R:Y102	4.37	1	Yes	Yes	0	7	0	1
R:R:L148	R:R:T188	2.95	1	No	Yes	4	5	2	2
L:L:?1	R:R:V152	2.78	1	Yes	No	0	4	0	1
R:R:E185	R:R:H181	7.39	0	No	Yes	5	5	1	2
R:R:E185	R:R:N241	2.63	0	No	No	5	6	1	2
L:L:?1	R:R:E185	8.24	1	Yes	No	0	5	0	1
R:R:F230	R:R:W234	5.01	1	No	Yes	9	9	2	1
R:R:H238	R:R:W234	3.17	0	Yes	Yes	8	9	2	1
R:R:A274	R:R:W234	5.19	0	No	Yes	8	9	2	1
R:R:S277	R:R:W234	7.41	0	No	Yes	9	9	2	1
L:L:?1	R:R:W234	3.54	1	Yes	Yes	0	9	0	1
R:R:H238	R:R:Y237	5.44	0	Yes	Yes	8	6	2	2
R:R:N241	R:R:Y237	15.12	0	No	Yes	6	6	2	2
R:R:I271	R:R:Y237	4.84	0	No	Yes	5	6	1	2
L:L:?1	R:R:N268	6.83	1	Yes	No	0	4	0	1
L:L:?1	R:R:I271	6.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:F275	3.03	1	Yes	No	0	6	0	1
L:L:?1	R:R:G98	2.13	1	Yes	No	0	4	0	1
R:R:C97	R:R:G98	1.96	0	No	No	6	4	2	1
R:R:W106	R:R:Y102	1.93	1	No	Yes	5	7	2	1
R:R:L78	R:R:S18	1.5	0	Yes	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VKT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.54
Number of Linked Nodes	256
Number of Links	275
Number of Hubs	33
Number of Links mediated by Hubs	133
Number of Communities	10
Number of Nodes involved in Communities	47
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	39793
Length Of Smallest Path	3
Average Path Length	12.0865
Length of Longest Path	31
Minimum Path Strength	1.38
Average Path Strength	4.88058
Maximum Path Strength	15.26
Minimum Path Correlation	0.7
Average Path Correlation	0.924765
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	51.8234
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.0964
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • immune response • immune system process • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • muscle contraction • muscle system process • defense response • response to stress • inflammatory response • cell periphery • cellular anatomical structure • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LTB
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LTB
Name	Leukotriene B4
Synonyms	LTB4 Leukotriene B4
Identifier
Formula	C20 H32 O4
Molecular Weight	336.466
SMILES
PubChem	5280492
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	2
Total Bonds	55
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15722
Sequence	>7VKT_nogp_Chain_R E F I S L L A I I L L S V A L A V G L P G N S F V V W S I L K R M Q K R S V T A L M V L N L A L A D L A V L L T A P F F L H F L A Q G T W S F G L A G C R L C H Y V C G V S M Y A S V W L I T A M S L D R S L A V A R P F V S Q K L R T K A M A R R V L A G I W V L S F L L A T P V L A Y R T V V P W K T N M S L C F P R Y P S E G H R A F H L I F E A V T G F L L P F L I V V A S Y S D I G R R L Q A R R F R R S R R T G R L V V L I I L T F A A F W L P Y H V V N L A E A G R A L A G Q A A G L G L V G K R L S L A R N V L I A L A F L S S S V N P V L Y A F A G G G L L R S A G V G F V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VKT	A	Lipid	Leukotriene	BLT₁	Homo sapiens	LTB4	-	Gi1/β1/γ2	2.9	2022-03-09	10.1038/s41467-022-28820-9
	7VKT (No Gprot)	A	Lipid	Leukotriene	BLT₁	Homo sapiens	LTB4	-		2.9	2022-03-09	10.1038/s41467-022-28820-9
	7K15	A	Lipid	Leukotriene	BLT₁	Homo sapiens	MKD046	Na	-	2.88	2021-02-17	10.1038/s41467-021-23149-1
	5X33	A	Lipid	Leukotriene	BLT₁	Cavia porcellus	BIIL260	-	-	3.7	2018-01-03	10.1038/nchembio.2547

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