psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T88	3.89	Yes	No	0	0	6
2	L:L:?1	R:R:F168	24.93	Yes	No	0	0	4
3	L:L:?1	R:R:L249	10.96	Yes	Yes	1	0	5
4	L:L:?1	R:R:I274	13.19	Yes	No	1	0	4
5	L:L:?1	R:R:H278	8.49	Yes	Yes	1	0	6
6	R:R:T11	R:R:V8	6.35	No	No	0	4	5
7	R:R:W268	R:R:Y9	3.86	No	No	0	1	5
8	R:R:Y271	R:R:Y9	3.97	No	No	0	3	5
9	R:R:I10	R:R:I64	5.89	No	No	0	6	6
10	R:R:E13	R:R:I60	4.1	No	Yes	1	6	6
11	R:R:E13	R:R:V275	4.28	No	No	1	6	5
12	R:R:E13	R:R:H278	8.62	No	Yes	1	6	6
13	R:R:I16	R:R:T279	3.04	No	No	0	7	5
14	R:R:A17	R:R:I60	4.87	No	Yes	0	6	6
15	R:R:I21	R:R:I53	2.94	No	No	5	6	7
16	R:R:I21	R:R:V57	4.61	No	No	0	6	5
17	R:R:G23	R:R:L26	3.42	No	No	0	9	6
18	R:R:D52	R:R:N24	12.12	Yes	No	0	9	9
19	R:R:I53	R:R:N24	7.08	No	No	0	7	9
20	R:R:F299	R:R:V27	3.93	Yes	No	0	6	9
21	R:R:W29	R:R:W32	4.69	No	No	0	4	3
22	R:R:A30	R:R:F295	2.77	No	Yes	6	8	8
23	R:R:A30	R:R:F299	4.16	No	Yes	6	8	6
24	R:R:L33	R:R:W32	3.42	No	No	0	5	3
25	R:R:N34	R:R:N36	12.26	No	No	0	6	5
26	R:R:L37	R:R:N34	10.98	No	No	0	8	6
27	R:R:N36	R:R:S35	4.47	No	No	0	5	5
28	R:R:Q38	R:R:S35	4.33	No	No	0	7	5
29	R:R:F295	R:R:L37	9.74	Yes	No	0	8	8
30	R:R:N39	R:R:N42	8.17	No	No	0	7	8
31	R:R:V40	R:R:Y43	3.79	No	No	0	6	5
32	R:R:V116	R:R:V40	3.21	No	No	0	7	6
33	R:R:N42	R:R:T41	5.85	No	No	0	8	8
34	R:R:D101	R:R:T41	5.78	No	No	0	9	8
35	R:R:A97	R:R:F44	2.77	No	Yes	0	7	7
36	R:R:F44	R:R:I98	3.77	Yes	Yes	0	7	8
37	R:R:D101	R:R:F44	3.58	No	Yes	0	9	7
38	R:R:A121	R:R:F44	2.77	No	Yes	0	7	7
39	R:R:F44	R:R:I124	3.77	Yes	No	0	7	5
40	R:R:F44	R:R:I125	5.02	Yes	No	0	7	8
41	R:R:S47	R:R:S94	4.89	No	No	0	9	7
42	R:R:I125	R:R:S47	3.1	No	No	0	8	9
43	R:R:D52	R:R:L48	9.5	Yes	Yes	2	9	9
44	R:R:I98	R:R:L48	2.85	Yes	Yes	2	8	9
45	R:R:L48	R:R:N284	5.49	Yes	Yes	2	9	9
46	R:R:L48	R:R:Y288	3.52	Yes	Yes	2	9	9
47	R:R:D52	R:R:S281	2.94	Yes	No	0	9	9
48	R:R:D52	R:R:N284	5.39	Yes	Yes	2	9	9
49	R:R:A54	R:R:L87	3.15	No	Yes	0	6	7
50	R:R:G56	R:R:V55	3.68	No	No	0	7	6
51	R:R:L87	R:R:V55	7.45	Yes	No	0	7	6
52	R:R:S281	R:R:V55	4.85	No	No	0	9	6
53	R:R:G56	R:R:I60	3.53	No	Yes	0	7	6
54	R:R:L58	R:R:V57	5.96	No	No	0	5	5
55	R:R:F83	R:R:L58	7.31	Yes	No	0	5	5
56	R:R:A59	R:R:F83	2.77	No	Yes	7	6	5
57	R:R:A59	R:R:V84	3.39	No	No	7	6	6
58	R:R:I60	R:R:P61	3.39	Yes	No	0	6	8
59	R:R:H278	R:R:I60	7.95	Yes	Yes	1	6	6
60	R:R:F62	R:R:I80	10.05	No	No	0	5	6
61	R:R:F62	R:R:F83	8.57	No	Yes	0	5	5
62	R:R:A63	R:R:H278	2.93	No	Yes	0	5	6
63	R:R:I64	R:R:S67	4.64	No	No	0	6	3
64	R:R:F70	R:R:I66	3.77	No	No	0	7	4
65	R:R:G69	R:R:T68	3.64	No	No	0	4	5
66	R:R:C77	R:R:F70	8.38	No	No	0	9	7
67	R:R:F70	R:R:V171	5.24	No	No	0	7	4
68	R:R:C74	R:R:C77	3.64	No	No	0	3	9
69	R:R:L78	R:R:M140	4.24	No	No	0	6	5
70	R:R:F79	R:R:M140	3.73	No	No	0	4	5
71	R:R:A81	R:R:F168	2.77	No	No	0	5	4
72	R:R:C82	R:R:L137	3.17	No	No	0	5	3
73	R:R:C82	R:R:P139	5.65	No	No	0	5	5
74	R:R:F83	R:R:V84	6.55	Yes	No	7	5	6
75	R:R:F83	R:R:L87	8.53	Yes	Yes	0	5	7
76	R:R:L87	R:R:V86	2.98	Yes	Yes	0	7	4
77	R:R:F133	R:R:V86	5.24	No	Yes	0	3	4
78	R:R:G136	R:R:V86	3.68	No	Yes	0	6	4
79	R:R:L137	R:R:V86	2.98	No	Yes	0	3	4
80	R:R:T88	R:R:W246	4.85	No	Yes	0	6	8
81	R:R:Q89	R:R:S132	4.33	Yes	No	0	5	7
82	R:R:I135	R:R:Q89	5.49	Yes	Yes	3	4	5
83	R:R:N181	R:R:Q89	5.28	Yes	Yes	3	5	5
84	R:R:C185	R:R:Q89	7.63	No	Yes	3	5	5
85	R:R:S90	R:R:W129	17.3	No	No	0	6	9
86	R:R:S132	R:R:S90	6.52	No	No	0	7	6
87	R:R:I92	R:R:S91	3.1	Yes	No	0	7	9
88	R:R:I92	R:R:P189	3.39	Yes	No	0	7	8
89	R:R:F242	R:R:I92	3.77	Yes	Yes	8	9	7
90	R:R:I92	R:R:W246	11.74	Yes	Yes	8	7	8
91	R:R:F93	R:R:L131	4.87	No	No	0	5	4
92	R:R:L95	R:R:Y288	5.86	No	Yes	0	8	9
93	R:R:L192	R:R:L96	2.77	No	No	0	6	7
94	R:R:I98	R:R:R102	3.76	Yes	No	2	8	9
95	R:R:I98	R:R:Y288	12.09	Yes	Yes	2	8	9
96	R:R:D101	R:R:Y112	3.45	No	Yes	0	9	7
97	R:R:R102	R:R:Y197	3.09	No	Yes	0	9	9
98	R:R:R102	R:R:Y288	3.09	No	Yes	2	9	9
99	R:R:R107	R:R:Y103	11.32	No	No	9	6	8
100	R:R:V196	R:R:Y103	10.09	No	No	0	7	8
101	R:R:R199	R:R:Y103	5.14	No	No	9	5	8
102	R:R:A105	R:R:Y112	8.01	No	Yes	0	8	7
103	R:R:I106	R:R:I200	4.42	No	No	0	8	9
104	R:R:I108	R:R:R107	3.76	No	No	0	5	6
105	R:R:R107	R:R:R199	13.86	No	No	9	6	5
106	R:R:V116	R:R:Y112	10.09	No	Yes	0	7	7
107	R:R:L115	R:R:R120	3.64	No	No	0	4	5
108	R:R:G118	R:R:T117	3.64	No	No	0	1	7
109	R:R:T117	R:R:T119	4.71	No	No	0	7	5
110	R:R:R120	R:R:T117	11.64	No	No	0	5	7
111	R:R:I127	R:R:L131	2.85	No	No	0	3	4
112	R:R:F133	R:R:W129	4.01	No	No	0	3	9
113	R:R:G136	R:R:I135	3.53	No	Yes	0	6	4
114	R:R:C185	R:R:I135	6.55	No	Yes	3	5	4
115	R:R:L137	R:R:M140	4.24	No	No	0	3	5
116	R:R:P139	R:R:T138	3.5	No	No	0	5	6
117	R:R:T138	R:R:Y176	3.75	No	Yes	0	6	6
118	R:R:W143	R:R:Y176	2.89	No	Yes	0	5	6
119	R:R:C146	R:R:N144	4.72	No	No	0	1	4
120	R:R:D170	R:R:L167	8.14	No	No	0	4	4
121	R:R:F168	R:R:V172	11.8	No	No	0	4	3
122	R:R:E169	R:R:M174	4.06	No	No	0	3	4
123	R:R:V171	R:R:V172	3.21	No	No	0	4	3
124	R:R:P173	R:R:V172	3.53	No	No	0	4	3
125	R:R:N175	R:R:P173	4.89	No	No	0	4	4
126	R:R:F180	R:R:Y176	5.16	No	Yes	0	4	6
127	R:R:N181	R:R:Y176	11.63	Yes	Yes	0	5	6
128	R:R:M177	R:R:N181	11.22	No	Yes	0	6	5
129	R:R:N253	R:R:V178	4.43	No	No	0	5	5
130	R:R:C254	R:R:V178	3.42	No	No	0	6	5
131	R:R:F257	R:R:V178	14.42	No	No	0	3	5
132	R:R:A184	R:R:F180	2.77	No	No	0	3	4
133	R:R:C185	R:R:N181	4.72	No	Yes	3	5	5
134	R:R:F182	R:R:L187	6.09	No	No	0	5	4
135	R:R:F182	R:R:H250	13.58	No	No	0	5	6
136	R:R:A184	R:R:F183	2.77	No	No	0	3	4
137	R:R:H250	R:R:V186	9.69	No	No	0	6	7
138	R:R:P189	R:R:V188	3.53	No	No	0	8	5
139	R:R:L192	R:R:V188	2.98	No	No	0	6	5
140	R:R:F242	R:R:L190	7.31	Yes	No	0	9	6
141	R:R:F242	R:R:M193	4.98	Yes	No	0	9	8
142	R:R:V196	R:R:Y197	3.79	No	Yes	0	7	9
143	R:R:L235	R:R:Y197	7.03	No	Yes	0	8	9
144	R:R:L198	R:R:L202	4.15	No	No	0	4	4
145	R:R:I200	R:R:L235	2.85	No	No	0	9	8
146	R:R:F201	R:R:R205	3.21	No	Yes	4	5	5
147	R:R:E228	R:R:F201	4.66	Yes	No	4	7	5
148	R:R:A232	R:R:F201	4.16	No	No	0	7	5
149	R:R:L202	R:R:R205	3.64	No	Yes	0	4	5
150	R:R:K209	R:R:R205	13.61	No	Yes	4	5	5
151	R:R:E228	R:R:R205	10.47	Yes	Yes	4	7	5
152	R:R:K209	R:R:R206	6.19	No	No	0	5	4
153	R:R:Q207	R:R:Q210	3.84	No	No	0	6	3
154	R:R:E212	R:R:L208	6.63	No	No	0	2	5
155	R:R:K227	R:R:L208	4.23	No	No	0	6	5
156	R:R:E228	R:R:K209	9.45	Yes	No	4	7	5
157	R:R:M211	R:R:Q210	10.88	No	No	0	4	3
158	R:R:S223	R:R:T224	3.2	No	No	0	4	5
159	R:R:L225	R:R:T224	2.95	No	No	0	4	5
160	R:R:A236	R:R:K233	3.21	No	No	0	5	7
161	R:R:I237	R:R:K233	7.27	No	No	0	6	7
162	R:R:I238	R:R:I287	5.89	No	No	0	8	8
163	R:R:I238	R:R:Y288	3.63	No	Yes	0	8	9
164	R:R:G240	R:R:V239	3.68	No	No	0	5	8
165	R:R:I287	R:R:L241	2.85	No	No	0	8	7
166	R:R:F242	R:R:W246	9.02	Yes	Yes	8	9	8
167	R:R:C245	R:R:N280	9.45	No	No	0	8	9
168	R:R:N280	R:R:W246	11.3	No	Yes	0	9	8
169	R:R:A273	R:R:L249	4.73	No	Yes	0	6	5
170	R:R:I274	R:R:L249	2.85	No	Yes	1	4	5
171	R:R:L249	R:R:S277	4.5	Yes	No	0	5	7
172	R:R:I252	R:R:M270	2.92	No	No	0	5	4
173	R:R:C259	R:R:F255	2.79	No	No	0	4	4
174	R:R:F257	R:R:F258	13.93	No	No	0	3	6
175	R:R:C259	R:R:C262	5.46	No	No	0	4	1
176	R:R:D261	R:R:P260	3.22	No	No	0	1	1
177	R:R:H264	R:R:L267	3.86	No	No	0	2	3
178	R:R:P266	R:R:W268	6.76	No	No	0	3	1
179	R:R:L267	R:R:Y271	5.86	No	No	0	3	3
180	R:R:L269	R:R:W268	5.69	No	No	0	4	1
181	R:R:L272	R:R:L276	4.15	No	No	1	5	7
182	R:R:H278	R:R:I274	5.3	Yes	No	1	6	4
183	R:R:T279	R:R:V282	4.76	No	No	0	5	7
184	R:R:N280	R:R:N284	9.54	No	Yes	0	9	9
185	R:R:N284	R:R:P285	6.52	Yes	No	0	9	9
186	R:R:R296	R:R:Y290	3.09	No	No	0	8	6
187	R:R:E294	R:R:I292	6.83	No	No	0	6	8
188	R:R:F295	R:R:I292	17.58	Yes	No	0	8	8
189	R:R:F295	R:R:F299	8.57	Yes	Yes	6	8	6
190	R:R:F299	R:R:T298	3.89	Yes	No	0	6	7
191	R:R:I303	R:R:R300	6.26	No	No	0	6	5
192	R:R:R300	R:R:R304	4.26	No	No	0	5	5
193	R:R:K301	R:R:R304	7.43	No	No	0	4	5
194	R:R:L78	R:R:N144	2.75	No	No	0	6	4
195	R:R:L85	R:R:N181	2.75	No	Yes	0	4	5
196	R:R:E228	R:R:L225	2.65	Yes	No	0	7	4
197	R:R:H250	R:R:M177	2.63	No	No	0	6	6
198	R:R:F295	R:R:V31	2.62	Yes	No	0	8	7
199	R:R:S67	R:R:Y271	2.54	No	No	0	3	3
200	R:R:V239	R:R:Y197	2.52	No	Yes	0	8	9
201	R:R:F93	R:R:I92	2.51	No	Yes	0	5	7
202	R:R:F93	R:R:I135	2.51	No	Yes	0	5	4
203	R:R:I108	R:R:R111	2.51	No	No	0	5	5
204	R:R:F257	R:R:M174	2.49	No	No	0	3	4
205	R:R:L115	R:R:R111	2.43	No	No	0	4	5
206	R:R:N113	R:R:Y112	2.33	No	Yes	0	5	7
207	R:R:A126	R:R:G123	1.95	No	No	0	4	3
208	R:R:A243	R:R:G240	1.95	No	No	0	5	5
209	R:R:C259	R:R:P260	1.88	No	No	0	4	1
210	L:L:?1	R:R:M270	1.87	Yes	No	0	0	4
211	R:R:A265	R:R:P266	1.87	No	No	0	4	3
212	R:R:A289	R:R:P285	1.87	No	No	0	7	9
213	R:R:G5	R:R:S6	1.86	No	No	0	5	4
214	R:R:C71	R:R:C74	1.82	No	No	0	2	3
215	R:R:A73	R:R:C71	1.81	No	No	0	7	2
216	R:R:P285	R:R:V27	1.77	No	No	0	9	9
217	R:R:G23	R:R:L22	1.71	No	No	0	9	5
218	R:R:A51	R:R:S90	1.71	No	No	0	8	6
219	R:R:G76	R:R:L78	1.71	No	No	0	6	6
220	R:R:G195	R:R:L194	1.71	No	No	0	4	4
221	R:R:G195	R:R:L198	1.71	No	No	0	4	4
222	R:R:C245	R:R:V283	1.71	No	No	0	8	6
223	R:R:A20	R:R:V282	1.7	No	No	0	7	7
224	R:R:A49	R:R:V27	1.7	No	No	0	9	9
225	R:R:G114	R:R:N113	1.7	No	No	0	5	5
226	R:R:I108	R:R:P109	1.69	No	No	0	5	8
227	R:R:C128	R:R:I125	1.64	No	No	0	7	8
228	R:R:L247	R:R:P248	1.64	No	No	0	6	9
229	R:R:C254	R:R:I251	1.64	No	No	0	6	5
230	R:R:N145	R:R:P173	1.63	No	No	0	4	4
231	R:R:A203	R:R:I106	1.62	No	No	0	6	8
232	R:R:A265	R:R:I252	1.62	No	No	0	4	5
233	R:R:A99	R:R:M193	1.61	No	No	0	9	8
234	R:R:T11	R:R:V12	1.59	No	No	0	4	5
235	R:R:T279	R:R:V283	1.59	No	No	0	5	6
236	R:R:A15	R:R:L19	1.58	No	No	0	5	5
237	R:R:A243	R:R:L247	1.58	No	No	0	5	6
238	R:R:I10	R:R:S7	1.55	No	No	0	6	4
239	R:R:I21	R:R:V25	1.54	No	No	5	6	4
240	R:R:I53	R:R:V25	1.54	No	No	5	7	4
241	R:R:I127	R:R:V130	1.54	No	No	0	3	4
242	R:R:I10	R:R:T11	1.52	No	No	0	6	4
243	R:R:I64	R:R:T65	1.52	No	No	0	6	5
244	R:R:I252	R:R:T256	1.52	No	No	0	5	4
245	R:R:L235	R:R:S234	1.5	No	No	0	8	8
246	R:R:L19	R:R:V18	1.49	No	No	0	5	4
247	R:R:L19	R:R:V282	1.49	No	No	0	5	7
248	R:R:L194	R:R:V239	1.49	No	No	0	4	8
249	R:R:L272	R:R:V275	1.49	No	No	1	5	5
250	R:R:L276	R:R:V275	1.49	No	No	1	7	5
251	R:R:I302	R:R:L26	1.43	No	No	0	6	6
252	R:R:I302	R:R:L33	1.43	No	No	0	6	5
253	R:R:M177	R:R:N253	1.4	No	No	0	6	5
254	R:R:L190	R:R:L191	1.38	No	No	0	6	3
255	R:R:L241	R:R:L244	1.38	No	No	0	7	5
256	R:R:E228	R:R:L208	1.33	Yes	No	0	7	5
257	R:R:F286	R:R:V283	1.31	No	No	0	6	6
258	R:R:I104	R:R:Y112	1.21	No	Yes	0	5	7
259	R:R:E294	R:R:R293	1.16	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.555	6	1	0
2	R:R:F44	3.61333	6	0	7
3	R:R:L48	5.34	4	2	9
4	R:R:D52	7.4875	4	2	9
5	R:R:I60	4.768	5	1	6
6	R:R:F83	6.746	5	7	5
7	R:R:V86	3.72	4	0	4
8	R:R:L87	5.5275	4	0	7
9	R:R:Q89	5.6825	4	3	5
10	R:R:I92	4.902	5	8	7
11	R:R:I98	5.6175	4	2	8
12	R:R:Y112	5.018	5	0	7
13	R:R:I135	4.52	4	3	4
14	R:R:Y176	5.8575	4	0	6
15	R:R:N181	7.12	5	3	5
16	R:R:Y197	4.1075	4	0	9
17	R:R:R205	7.7325	4	4	5
18	R:R:E228	5.712	5	4	7
19	R:R:F242	6.27	4	8	9
20	R:R:W246	9.2275	4	8	8
21	R:R:L249	5.76	4	1	5
22	R:R:H278	6.658	5	1	6
23	R:R:N284	6.735	4	2	9
24	R:R:Y288	5.638	5	2	9
25	R:R:F295	8.256	5	6	8
26	R:R:F299	5.1375	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M270	32.9991	1.87	Yes	No	0	0	4
2	R:R:I252	R:R:M270	31.5358	2.92	No	No	0	5	4
3	R:R:A265	R:R:I252	28.3924	1.62	No	No	0	4	5
4	R:R:A265	R:R:P266	26.7191	1.87	No	No	0	4	3
5	R:R:P266	R:R:W268	25.0322	6.76	No	No	0	3	1
6	R:R:W268	R:R:Y9	21.6178	3.86	No	No	0	1	5
7	R:R:Y271	R:R:Y9	19.8903	3.97	No	No	0	3	5
8	R:R:S67	R:R:Y271	14.6196	2.54	No	No	0	3	3
9	R:R:I64	R:R:S67	12.8447	4.64	No	No	0	6	3
10	L:L:?1	R:R:H278	13.6712	8.49	Yes	Yes	1	0	6
11	R:R:H278	R:R:I60	10.0603	7.95	Yes	Yes	1	6	6
12	L:L:?1	R:R:T88	57.11	3.89	Yes	No	0	0	6
13	R:R:T88	R:R:W246	58.2887	4.85	No	Yes	0	6	8
14	R:R:N280	R:R:W246	97.8389	11.3	No	Yes	0	9	8
15	R:R:C245	R:R:N280	19.2331	9.45	No	No	0	8	9
16	R:R:C245	R:R:V283	17.3701	1.71	No	No	0	8	6
17	R:R:T279	R:R:V283	13.6034	1.59	No	No	0	5	6
18	R:R:N280	R:R:N284	100	9.54	No	Yes	0	9	9
19	R:R:D52	R:R:N284	10.2906	5.39	Yes	Yes	2	9	9
20	R:R:G56	R:R:I60	18.5963	3.53	No	Yes	0	7	6
21	R:R:G56	R:R:V55	19.6938	3.68	No	No	0	7	6
22	R:R:L87	R:R:V55	34.7808	7.45	Yes	No	0	7	6
23	R:R:F83	R:R:L87	13.495	8.53	Yes	Yes	0	5	7
24	R:R:N284	R:R:P285	30.9125	6.52	Yes	No	0	9	9
25	R:R:P285	R:R:V27	27.4575	1.77	No	No	0	9	9
26	R:R:F299	R:R:V27	23.9347	3.93	Yes	No	0	6	9
27	R:R:F295	R:R:F299	18.6844	8.57	Yes	Yes	6	8	6
28	R:R:L48	R:R:N284	93.2389	5.49	Yes	Yes	2	9	9
29	R:R:I98	R:R:L48	70.7743	2.85	Yes	Yes	2	8	9
30	R:R:F44	R:R:I98	29.4018	3.77	Yes	Yes	0	7	8
31	R:R:D101	R:R:F44	18.3524	3.58	No	Yes	0	9	7
32	R:R:D101	R:R:Y112	12.3975	3.45	No	Yes	0	9	7
33	R:R:L48	R:R:Y288	53.3365	3.52	Yes	Yes	2	9	9
34	R:R:S281	R:R:V55	34.0492	4.85	No	No	0	9	6
35	L:L:?1	R:R:F168	22.8982	24.93	Yes	No	0	0	4
36	R:R:F168	R:R:V172	19.7277	11.8	No	No	0	4	3
37	R:R:V171	R:R:V172	12.8447	3.21	No	No	0	4	3
38	R:R:F70	R:R:V171	11.0494	5.24	No	No	0	7	4
39	R:R:L87	R:R:V86	30.2757	2.98	Yes	Yes	0	7	4
40	R:R:L137	R:R:V86	18.1898	2.98	No	Yes	0	3	4
41	R:R:L137	R:R:M140	12.0656	4.24	No	No	0	3	5
42	R:R:I92	R:R:W246	71.1469	11.74	Yes	Yes	8	7	8
43	R:R:F93	R:R:I92	69.0062	2.51	No	Yes	0	5	7
44	R:R:F93	R:R:I135	65.6121	2.51	No	Yes	0	5	4
45	R:R:G136	R:R:I135	13.9083	3.53	No	Yes	0	6	4
46	R:R:I135	R:R:Q89	36.6777	5.49	Yes	Yes	3	4	5
47	R:R:C185	R:R:I135	33.8324	6.55	No	Yes	3	5	4
48	R:R:C185	R:R:N181	32.3962	4.72	No	Yes	3	5	5
49	R:R:I98	R:R:R102	52.0832	3.76	Yes	No	2	8	9
50	R:R:R102	R:R:Y197	97.7847	3.09	No	Yes	0	9	9
51	R:R:V196	R:R:Y197	32.3284	3.79	No	Yes	0	7	9
52	R:R:V196	R:R:Y103	29.6863	10.09	No	No	0	7	8
53	R:R:R107	R:R:Y103	24.3005	11.32	No	No	9	6	8
54	R:R:R102	R:R:Y288	47.8626	3.09	No	Yes	2	9	9
55	R:R:L235	R:R:Y197	13.7863	7.03	No	Yes	0	8	9
56	R:R:I108	R:R:R107	21.672	3.76	No	No	0	5	6
57	R:R:I108	R:R:R111	16.2658	2.51	No	No	0	5	5
58	R:R:L115	R:R:R111	13.5424	2.43	No	No	0	4	5
59	R:R:L115	R:R:R120	10.8055	3.64	No	No	0	4	5
60	R:R:N181	R:R:Q89	32.9923	5.28	Yes	Yes	3	5	5
61	R:R:N181	R:R:Y176	18.9079	11.63	Yes	Yes	0	5	6
62	R:R:M177	R:R:N181	43.1475	11.22	No	Yes	0	6	5
63	R:R:M177	R:R:N253	26.6107	1.4	No	No	0	6	5
64	R:R:N253	R:R:V178	23.5621	4.43	No	No	0	5	5
65	R:R:F257	R:R:V178	13.4408	14.42	No	No	0	3	5
66	R:R:F180	R:R:Y176	10.5413	5.16	No	Yes	0	4	6
67	R:R:H250	R:R:M177	13.6712	2.63	No	No	0	6	6
68	R:R:V239	R:R:Y197	55.1995	2.52	No	Yes	0	8	9
69	R:R:L194	R:R:V239	42.5107	1.49	No	No	0	4	8
70	R:R:G195	R:R:L194	39.9228	1.71	No	No	0	4	4
71	R:R:G195	R:R:L198	37.3213	1.71	No	No	0	4	4
72	R:R:L198	R:R:L202	34.7063	4.15	No	No	0	4	4
73	R:R:L202	R:R:R205	32.0778	3.64	No	Yes	0	4	5
74	R:R:E228	R:R:R205	18.7928	10.47	Yes	Yes	4	7	5
75	R:R:G240	R:R:V239	11.0765	3.68	No	No	0	5	8
76	R:R:D52	R:R:S281	34.2524	2.94	Yes	No	0	9	9
77	R:R:G136	R:R:V86	14.1657	3.68	No	Yes	0	6	4
78	R:R:D52	R:R:L48	31.3664	9.5	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T88	3.89	1	Yes	No	0	6	0	1
L:L:?1	R:R:F168	24.93	1	Yes	No	0	4	0	1
L:L:?1	R:R:L249	10.96	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I274	13.19	1	Yes	No	0	4	0	1
L:L:?1	R:R:H278	8.49	1	Yes	Yes	0	6	0	1
R:R:E13	R:R:I60	4.1	1	No	Yes	6	6	2	2
R:R:E13	R:R:H278	8.62	1	No	Yes	6	6	2	1
R:R:H278	R:R:I60	7.95	1	Yes	Yes	6	6	1	2
R:R:A63	R:R:H278	2.93	0	No	Yes	5	6	2	1
R:R:A81	R:R:F168	2.77	0	No	No	5	4	2	1
R:R:T88	R:R:W246	4.85	0	No	Yes	6	8	1	2
R:R:F168	R:R:V172	11.8	0	No	No	4	3	1	2
R:R:A273	R:R:L249	4.73	0	No	Yes	6	5	2	1
R:R:I274	R:R:L249	2.85	1	No	Yes	4	5	1	1
R:R:L249	R:R:S277	4.5	1	Yes	No	5	7	1	2
R:R:I252	R:R:M270	2.92	0	No	No	5	4	2	1
R:R:H278	R:R:I274	5.3	1	Yes	No	6	4	1	1
L:L:?1	R:R:M270	1.87	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EE9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	249
Number of Links	259
Number of Hubs	26
Number of Links mediated by Hubs	97
Number of Communities	9
Number of Nodes involved in Communities	38
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	35045
Length Of Smallest Path	3
Average Path Length	13.6774
Length of Longest Path	31
Minimum Path Strength	1.45
Average Path Strength	5.36709
Maximum Path Strength	19.06
Minimum Path Correlation	0.7
Average Path Correlation	0.931204
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	49.7855
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.6006
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • calmodulin binding • identical protein binding • cytoskeletal protein binding • alpha-actinin binding • actinin binding • lipid binding • type 5 metabotropic glutamate receptor binding • glutamate receptor binding • G protein-coupled glutamate receptor binding • response to xenobiotic stimulus • regulation of alpha-beta T cell activation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • negative regulation of lymphocyte activation • leukocyte cell-cell adhesion • negative regulation of cell adhesion • leukocyte activation • T cell activation • negative regulation of cellular process • alpha-beta T cell activation • regulation of cell-cell adhesion • regulation of cell adhesion • regulation of T cell activation • negative regulation of cell activation • negative regulation of T cell activation • negative regulation of leukocyte cell-cell adhesion • negative regulation of cell-cell adhesion • regulation of leukocyte cell-cell adhesion • negative regulation of alpha-beta T cell activation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • regulation of lymphocyte activation • central nervous system development • nervous system development • trans-synaptic signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • positive regulation of signal transduction • regulation of signal transduction • regulation of programmed cell death • positive regulation of apoptotic signaling pathway • positive regulation of response to stimulus • positive regulation of programmed cell death • regulation of apoptotic process • cell death • positive regulation of apoptotic process • apoptotic signaling pathway • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • regulation of calcium ion transport • regulation of monoatomic ion transport • metal ion transport • calcium ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • import into cell • phagocytosis • endocytosis • vesicle-mediated transport • response to purine-containing compound • response to caffeine • response to alkaloid • purinergic nucleotide receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • negative regulation of vascular permeability • regulation of vascular permeability • circulatory system process • vascular process in circulatory system • blood circulation • startle response • prepulse inhibition • positive regulation of neurotransmitter secretion • positive regulation of amine transport • acetylcholine secretion, neurotransmission • positive regulation of acetylcholine secretion, neurotransmission • positive regulation of neurotransmitter transport • positive regulation of synaptic transmission, cholinergic • neurotransmitter secretion • positive regulation of synaptic transmission • regulation of acetylcholine secretion, neurotransmission • neurotransmitter transport • organic cation transport • acetate ester transport • signal release from synapse • acetylcholine transport • acetylcholine secretion • regulation of neurotransmitter transport • amine transport • regulation of neurotransmitter secretion • synaptic transmission, cholinergic • regulation of amine transport • regulation of synaptic transmission, cholinergic • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • glial cell differentiation • glial cell activation • neuroinflammatory response • synaptic transmission, dopaminergic • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • inhibitory postsynaptic potential • regulation of membrane potential • cellular defense response • behavior • locomotory behavior • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • long-term synaptic potentiation • positive regulation of long-term synaptic potentiation • regulation of synaptic plasticity • regulation of long-term synaptic potentiation • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of synaptic transmission, glutamatergic • regulation of mitochondrial membrane potential • positive regulation of synaptic transmission, GABAergic • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • positive regulation of urine volume • regulation of urine volume • eating behavior • feeding behavior • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • circadian behavior • positive regulation of behavior • positive regulation of circadian rhythm • sleep • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • catecholamine transport • norepinephrine transport • catecholamine secretion • norepinephrine secretion • regulation of norepinephrine secretion • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of neuron apoptotic process • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • generation of neurons • neuron development • regulation of tube diameter • regulation of tube size • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • excitatory postsynaptic potential • negative regulation of cell population proliferation • regulation of cell population proliferation • response to amine • response to amphetamine • membrane depolarization • regulation of glutamate secretion • regulation of amino acid transport • glutamate secretion • organic anion transport • carboxylic acid transport • positive regulation of glutamate secretion • positive regulation of organic acid transport • organic acid transport • amino acid transport • acidic amino acid transport • positive regulation of amino acid transport • regulation of organic acid transport • dicarboxylic acid transport • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic active zone • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • glutamatergic synapse • axon • cell leading edge • axolemma • leading edge membrane • neuron projection membrane • main axon • cell projection membrane • cell body • neuronal cell body • polymeric cytoskeletal fiber • intracellular membraneless organelle • intermediate filament cytoskeleton • cytoskeleton • membraneless organelle • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex • neuron to neuron synapse • asymmetric synapse
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADN
Name	Adenosine
Synonyms	9-beta-D-Ribofuranosyl-9H-purin-6-amine
Identifier
Formula	C10 H13 N5 O4
Molecular Weight	267.241
SMILES
PubChem	60961
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	4
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29274
Sequence	>9EE9_nogp_Chain_R G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N S N L Q N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G F C A A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I P L R Y N G L V T G T R A K G I I A I C W V L S F A I G L T P M L G W N N C G L F E D V V P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S T L Q K E H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P D C S H A P L W L M Y L A I V L S H T N S V V N P F I Y A Y I R E F R Q T F R K I I R S H V C A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3EML	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.6	2008-10-14	doi.org/10.1126/science.1164772
	3QAK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.71	2011-03-09	doi.org/10.1126/science.1202793
	2YDO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	-	3	2011-05-18	doi.org/10.1038/nature10136
	2YDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	-	2.6	2011-05-18	doi.org/10.1038/nature10136
	3PWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.3	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3REY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 5697	-	-	3.31	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3RFM	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	-	-	3.6	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3VG9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	2.7	2012-02-01	doi.org/10.1038/nature10750
	3VGA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	3.1	2012-02-01	doi.org/10.1038/nature10750
	3UZA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	GTPL9236	-	-	3.27	2012-03-21	doi.org/10.1021/jm201376w
	3UZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	-	-	3.34	2012-03-21	doi.org/10.1021/jm201376w
	4EIY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2012-07-25	doi.org/10.1126/science.1219218
	4UG2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	4UHR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	5IU4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.72	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456346	Na	-	1.9	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456347	Na	-	2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456348	Na	-	2.2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456344	Na	-	2.1	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5G53	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs	3.4	2016-08-03	doi.org/10.1038/nature18966
	5G53 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		3.4	2016-08-03	doi.org/10.1038/nature18966
	5K2A	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2B	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2C	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2D	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	5UIG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 124081196	-	-	3.5	2017-02-08	doi.org/10.1073/pnas.1621423114
	5UVI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.2	2017-05-24	doi.org/10.1107/S205225251700570X
	5JTB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.8	2017-05-31	doi.org/10.1126/sciadv.1602952
	5MZJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	2	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5MZP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	Na	-	2.1	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5N2R	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB36	Na	-	2.8	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5NLX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.14	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5VRA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.35	2017-12-13	doi.org/10.1038/nprot.2017.135
	6AQF	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.51	2018-01-10	doi.org/10.1016/j.cell.2017.12.004
	5OLG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.87	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Vipadenant	Na	-	2.6	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Tozadenant	Na	-	3.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA47070	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	1.9	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM1	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5WF5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.6	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	5WF6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.9	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	6GDG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs/β1/γ1	4.11	2018-05-16	doi.org/10.7554/eLife.35946
	6GDG (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		4.11	2018-05-16	doi.org/10.7554/eLife.35946
	6MH8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	4.2	2019-04-24	doi.org/10.1107/S205225251900263X
	6GT3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Imaradenant	Na	-	2	2019-06-26	doi.org/10.1136/jitc-2019-000417
	6JZH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.25	2019-10-30	doi.org/10.1107/S1600576719012846
	6PS7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.85	2019-11-13	doi.org/10.1107/S2052252519013137
	6S0L	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	6S0Q	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	6ZDR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	HMS1413f12	Na	-	1.92	2020-09-16	doi.org/10.1002/anie.202003788
	6ZDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 984073	Na	-	2.13	2020-09-16	doi.org/10.1002/anie.202003788
	6WQA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-18	doi.org/10.1107/S2052252520012701
	6LPJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPL	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	7ARO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5833	Na	-	3.12	2021-04-07	doi.org/10.1021/acs.jmedchem.0c01856
	7RM5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.79	2021-09-08	doi.org/10.1073/pnas.2106041118
	7PX4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2113	-	-	2.25	2022-03-02	doi.org/10.1002/anie.202115545
	7PYR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2115	-	-	2.6	2022-03-02	doi.org/10.1002/anie.202115545
	7EZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	3.8	2022-04-13	doi.org/10.1107/S2052252522001907
	7T32	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.4	2022-08-10	doi.org/10.1038/s41467-022-32125-2
	8DU3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 105526064	-	-	2.5	2022-08-10	doi.org/10.1016/j.ejmech.2022.114620
	8CU6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	-	-	2.8	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	8CU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	Na	-	2.05	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	8FYN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2023-03-08	doi.org/10.1038/s41467-023-36733-4
	8GNE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	KW-6356	Na	-	2.3	2023-03-22	doi.org/10.1124/molpharm.122.000633
	8GNG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	-	-	3.2	2023-03-22	doi.org/10.1124/molpharm.122.000633
	8CIC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	Na	-	2.1	2023-05-31	doi.org/10.1038/s42004-023-00894-6
	8C9W	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	-	-	2.11	2023-07-12	doi.org/10.1038/s42004-023-00894-6
	8JWY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	2-118	-	-	2.33	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	8JWZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	Na	-	2.37	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	8A2O	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	3.45	2023-08-30	doi.org/10.1107/S1600576723006428
	8A2P	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA47070	Na	-	3.5	2023-08-30	doi.org/10.1107/S1600576723006428
	8PWN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	-	-	2.75	2023-10-25	doi.org/10.1038/s42004-023-01014-0
	8WDT	A	Nucleotide	Adenosine	A_2A	Homo sapiens	photoNECA	-	-	3.34	2024-01-17	doi.org/10.1016/j.bbrc.2023.149393
	8RQQ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.37	2024-04-03	doi.org/10.1021/acs.cgd.4c00087
	8RLN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5834	-	-	2.43	2024-06-19	doi.org/10.1021/acsptsci.4c00051
	8UGW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	3.9	2024-12-18	doi.org/10.1038/s41557-024-01719-2
	8RVW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.65	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW0	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	1.94	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	AzoSwitch2	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch1	Na	-	2.25	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.31	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWD	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch4	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.45	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.8	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	3.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	9FUP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	2.5	2025-01-22	doi.org/10.1038/s42004-024-01404-y
	9EE8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE8 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 175670644	Na	-	1.75	2025-06-18	doi.org/10.1038/s41467-025-60629-0
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 175670646	Na	-	1.71	2025-06-18	doi.org/10.1038/s41467-025-60629-0
	9P1S	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.34	2025-12-24	10.1038/s42004-025-01825-3
	9P1T	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.15	2025-12-24	10.1038/s42004-025-01825-3

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