psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T88	3.89	Yes	No	0	0	6
2	L:L:?1	R:R:F168	24.93	Yes	No	0	0	4
3	L:L:?1	R:R:L249	10.96	Yes	Yes	1	0	5
4	L:L:?1	R:R:I274	13.19	Yes	No	1	0	4
5	L:L:?1	R:R:H278	8.49	Yes	Yes	1	0	6
6	R:R:T11	R:R:V8	6.35	No	No	0	4	5
7	R:R:W268	R:R:Y9	3.86	No	No	0	1	5
8	R:R:Y271	R:R:Y9	3.97	No	No	0	3	5
9	R:R:I10	R:R:I64	5.89	No	No	0	6	6
10	R:R:E13	R:R:I60	4.1	No	Yes	1	6	6
11	R:R:E13	R:R:V275	4.28	No	No	1	6	5
12	R:R:E13	R:R:H278	8.62	No	Yes	1	6	6
13	R:R:I16	R:R:T279	3.04	No	No	0	7	5
14	R:R:A17	R:R:I60	4.87	No	Yes	0	6	6
15	R:R:I21	R:R:I53	2.94	No	No	5	6	7
16	R:R:I21	R:R:V57	4.61	No	No	0	6	5
17	R:R:G23	R:R:L26	3.42	No	No	0	9	6
18	R:R:D52	R:R:N24	12.12	Yes	No	0	9	9
19	R:R:I53	R:R:N24	7.08	No	No	0	7	9
20	R:R:F299	R:R:V27	3.93	Yes	No	0	6	9
21	R:R:W29	R:R:W32	4.69	No	No	0	4	3
22	R:R:A30	R:R:F295	2.77	No	Yes	6	8	8
23	R:R:A30	R:R:F299	4.16	No	Yes	6	8	6
24	R:R:L33	R:R:W32	3.42	No	No	0	5	3
25	R:R:N34	R:R:N36	12.26	No	No	0	6	5
26	R:R:L37	R:R:N34	10.98	No	No	0	8	6
27	R:R:N36	R:R:S35	4.47	No	No	0	5	5
28	R:R:Q38	R:R:S35	4.33	No	No	0	7	5
29	R:R:F295	R:R:L37	9.74	Yes	No	0	8	8
30	R:R:N39	R:R:N42	8.17	No	No	0	7	8
31	R:R:V40	R:R:Y43	3.79	No	No	0	6	5
32	R:R:V116	R:R:V40	3.21	No	No	0	7	6
33	R:R:N42	R:R:T41	5.85	No	No	0	8	8
34	R:R:D101	R:R:T41	5.78	No	No	0	9	8
35	R:R:A97	R:R:F44	2.77	No	Yes	0	7	7
36	R:R:F44	R:R:I98	3.77	Yes	Yes	0	7	8
37	R:R:D101	R:R:F44	3.58	No	Yes	0	9	7
38	R:R:A121	R:R:F44	2.77	No	Yes	0	7	7
39	R:R:F44	R:R:I124	3.77	Yes	No	0	7	5
40	R:R:F44	R:R:I125	5.02	Yes	No	0	7	8
41	R:R:S47	R:R:S94	4.89	No	No	0	9	7
42	R:R:I125	R:R:S47	3.1	No	No	0	8	9
43	R:R:D52	R:R:L48	9.5	Yes	Yes	2	9	9
44	R:R:I98	R:R:L48	2.85	Yes	Yes	2	8	9
45	R:R:L48	R:R:N284	5.49	Yes	Yes	2	9	9
46	R:R:L48	R:R:Y288	3.52	Yes	Yes	2	9	9
47	R:R:D52	R:R:S281	2.94	Yes	No	0	9	9
48	R:R:D52	R:R:N284	5.39	Yes	Yes	2	9	9
49	R:R:A54	R:R:L87	3.15	No	Yes	0	6	7
50	R:R:G56	R:R:V55	3.68	No	No	0	7	6
51	R:R:L87	R:R:V55	7.45	Yes	No	0	7	6
52	R:R:S281	R:R:V55	4.85	No	No	0	9	6
53	R:R:G56	R:R:I60	3.53	No	Yes	0	7	6
54	R:R:L58	R:R:V57	5.96	No	No	0	5	5
55	R:R:F83	R:R:L58	7.31	Yes	No	0	5	5
56	R:R:A59	R:R:F83	2.77	No	Yes	7	6	5
57	R:R:A59	R:R:V84	3.39	No	No	7	6	6
58	R:R:I60	R:R:P61	3.39	Yes	No	0	6	8
59	R:R:H278	R:R:I60	7.95	Yes	Yes	1	6	6
60	R:R:F62	R:R:I80	10.05	No	No	0	5	6
61	R:R:F62	R:R:F83	8.57	No	Yes	0	5	5
62	R:R:A63	R:R:H278	2.93	No	Yes	0	5	6
63	R:R:I64	R:R:S67	4.64	No	No	0	6	3
64	R:R:F70	R:R:I66	3.77	No	No	0	7	4
65	R:R:G69	R:R:T68	3.64	No	No	0	4	5
66	R:R:C77	R:R:F70	8.38	No	No	0	9	7
67	R:R:F70	R:R:V171	5.24	No	No	0	7	4
68	R:R:C74	R:R:C77	3.64	No	No	0	3	9
69	R:R:L78	R:R:M140	4.24	No	No	0	6	5
70	R:R:F79	R:R:M140	3.73	No	No	0	4	5
71	R:R:A81	R:R:F168	2.77	No	No	0	5	4
72	R:R:C82	R:R:L137	3.17	No	No	0	5	3
73	R:R:C82	R:R:P139	5.65	No	No	0	5	5
74	R:R:F83	R:R:V84	6.55	Yes	No	7	5	6
75	R:R:F83	R:R:L87	8.53	Yes	Yes	0	5	7
76	R:R:L87	R:R:V86	2.98	Yes	Yes	0	7	4
77	R:R:F133	R:R:V86	5.24	No	Yes	0	3	4
78	R:R:G136	R:R:V86	3.68	No	Yes	0	6	4
79	R:R:L137	R:R:V86	2.98	No	Yes	0	3	4
80	R:R:T88	R:R:W246	4.85	No	Yes	0	6	8
81	R:R:Q89	R:R:S132	4.33	Yes	No	0	5	7
82	R:R:I135	R:R:Q89	5.49	Yes	Yes	3	4	5
83	R:R:N181	R:R:Q89	5.28	Yes	Yes	3	5	5
84	R:R:C185	R:R:Q89	7.63	No	Yes	3	5	5
85	R:R:S90	R:R:W129	17.3	No	No	0	6	9
86	R:R:S132	R:R:S90	6.52	No	No	0	7	6
87	R:R:I92	R:R:S91	3.1	Yes	No	0	7	9
88	R:R:I92	R:R:P189	3.39	Yes	No	0	7	8
89	R:R:F242	R:R:I92	3.77	Yes	Yes	8	9	7
90	R:R:I92	R:R:W246	11.74	Yes	Yes	8	7	8
91	R:R:F93	R:R:L131	4.87	No	No	0	5	4
92	R:R:L95	R:R:Y288	5.86	No	Yes	0	8	9
93	R:R:L192	R:R:L96	2.77	No	No	0	6	7
94	R:R:I98	R:R:R102	3.76	Yes	No	2	8	9
95	R:R:I98	R:R:Y288	12.09	Yes	Yes	2	8	9
96	R:R:D101	R:R:Y112	3.45	No	Yes	0	9	7
97	R:R:R102	R:R:Y197	3.09	No	Yes	0	9	9
98	R:R:R102	R:R:Y288	3.09	No	Yes	2	9	9
99	R:R:R107	R:R:Y103	11.32	No	No	9	6	8
100	R:R:V196	R:R:Y103	10.09	No	No	0	7	8
101	R:R:R199	R:R:Y103	5.14	No	No	9	5	8
102	R:R:A105	R:R:Y112	8.01	No	Yes	0	8	7
103	R:R:I106	R:R:I200	4.42	No	No	0	8	9
104	R:R:I108	R:R:R107	3.76	No	No	0	5	6
105	R:R:R107	R:R:R199	13.86	No	No	9	6	5
106	R:R:V116	R:R:Y112	10.09	No	Yes	0	7	7
107	R:R:L115	R:R:R120	3.64	No	No	0	4	5
108	R:R:G118	R:R:T117	3.64	No	No	0	1	7
109	R:R:T117	R:R:T119	4.71	No	No	0	7	5
110	R:R:R120	R:R:T117	11.64	No	No	0	5	7
111	R:R:I127	R:R:L131	2.85	No	No	0	3	4
112	R:R:F133	R:R:W129	4.01	No	No	0	3	9
113	R:R:G136	R:R:I135	3.53	No	Yes	0	6	4
114	R:R:C185	R:R:I135	6.55	No	Yes	3	5	4
115	R:R:L137	R:R:M140	4.24	No	No	0	3	5
116	R:R:P139	R:R:T138	3.5	No	No	0	5	6
117	R:R:T138	R:R:Y176	3.75	No	Yes	0	6	6
118	R:R:W143	R:R:Y176	2.89	No	Yes	0	5	6
119	R:R:C146	R:R:N144	4.72	No	No	0	1	4
120	R:R:D170	R:R:L167	8.14	No	No	0	4	4
121	R:R:F168	R:R:V172	11.8	No	No	0	4	3
122	R:R:E169	R:R:M174	4.06	No	No	0	3	4
123	R:R:V171	R:R:V172	3.21	No	No	0	4	3
124	R:R:P173	R:R:V172	3.53	No	No	0	4	3
125	R:R:N175	R:R:P173	4.89	No	No	0	4	4
126	R:R:F180	R:R:Y176	5.16	No	Yes	0	4	6
127	R:R:N181	R:R:Y176	11.63	Yes	Yes	0	5	6
128	R:R:M177	R:R:N181	11.22	No	Yes	0	6	5
129	R:R:N253	R:R:V178	4.43	No	No	0	5	5
130	R:R:C254	R:R:V178	3.42	No	No	0	6	5
131	R:R:F257	R:R:V178	14.42	No	No	0	3	5
132	R:R:A184	R:R:F180	2.77	No	No	0	3	4
133	R:R:C185	R:R:N181	4.72	No	Yes	3	5	5
134	R:R:F182	R:R:L187	6.09	No	No	0	5	4
135	R:R:F182	R:R:H250	13.58	No	No	0	5	6
136	R:R:A184	R:R:F183	2.77	No	No	0	3	4
137	R:R:H250	R:R:V186	9.69	No	No	0	6	7
138	R:R:P189	R:R:V188	3.53	No	No	0	8	5
139	R:R:L192	R:R:V188	2.98	No	No	0	6	5
140	R:R:F242	R:R:L190	7.31	Yes	No	0	9	6
141	R:R:F242	R:R:M193	4.98	Yes	No	0	9	8
142	R:R:V196	R:R:Y197	3.79	No	Yes	0	7	9
143	R:R:L235	R:R:Y197	7.03	No	Yes	0	8	9
144	R:R:L198	R:R:L202	4.15	No	No	0	4	4
145	R:R:I200	R:R:L235	2.85	No	No	0	9	8
146	R:R:F201	R:R:R205	3.21	No	Yes	4	5	5
147	R:R:E228	R:R:F201	4.66	Yes	No	4	7	5
148	R:R:A232	R:R:F201	4.16	No	No	0	7	5
149	R:R:L202	R:R:R205	3.64	No	Yes	0	4	5
150	R:R:K209	R:R:R205	13.61	No	Yes	4	5	5
151	R:R:E228	R:R:R205	10.47	Yes	Yes	4	7	5
152	R:R:K209	R:R:R206	6.19	No	No	0	5	4
153	R:R:Q207	R:R:Q210	3.84	No	No	0	6	3
154	R:R:E212	R:R:L208	6.63	No	No	0	2	5
155	R:R:K227	R:R:L208	4.23	No	No	0	6	5
156	R:R:E228	R:R:K209	9.45	Yes	No	4	7	5
157	R:R:M211	R:R:Q210	10.88	No	No	0	4	3
158	R:R:S223	R:R:T224	3.2	No	No	0	4	5
159	R:R:L225	R:R:T224	2.95	No	No	0	4	5
160	R:R:A236	R:R:K233	3.21	No	No	0	5	7
161	R:R:I237	R:R:K233	7.27	No	No	0	6	7
162	R:R:I238	R:R:I287	5.89	No	No	0	8	8
163	R:R:I238	R:R:Y288	3.63	No	Yes	0	8	9
164	R:R:G240	R:R:V239	3.68	No	No	0	5	8
165	R:R:I287	R:R:L241	2.85	No	No	0	8	7
166	R:R:F242	R:R:W246	9.02	Yes	Yes	8	9	8
167	R:R:C245	R:R:N280	9.45	No	No	0	8	9
168	R:R:N280	R:R:W246	11.3	No	Yes	0	9	8
169	R:R:A273	R:R:L249	4.73	No	Yes	0	6	5
170	R:R:I274	R:R:L249	2.85	No	Yes	1	4	5
171	R:R:L249	R:R:S277	4.5	Yes	No	0	5	7
172	R:R:I252	R:R:M270	2.92	No	No	0	5	4
173	R:R:C259	R:R:F255	2.79	No	No	0	4	4
174	R:R:F257	R:R:F258	13.93	No	No	0	3	6
175	R:R:C259	R:R:C262	5.46	No	No	0	4	1
176	R:R:D261	R:R:P260	3.22	No	No	0	1	1
177	R:R:H264	R:R:L267	3.86	No	No	0	2	3
178	R:R:P266	R:R:W268	6.76	No	No	0	3	1
179	R:R:L267	R:R:Y271	5.86	No	No	0	3	3
180	R:R:L269	R:R:W268	5.69	No	No	0	4	1
181	R:R:L272	R:R:L276	4.15	No	No	1	5	7
182	R:R:H278	R:R:I274	5.3	Yes	No	1	6	4
183	R:R:T279	R:R:V282	4.76	No	No	0	5	7
184	R:R:N280	R:R:N284	9.54	No	Yes	0	9	9
185	R:R:N284	R:R:P285	6.52	Yes	No	0	9	9
186	R:R:R296	R:R:Y290	3.09	No	No	0	8	6
187	R:R:E294	R:R:I292	6.83	No	No	0	6	8
188	R:R:F295	R:R:I292	17.58	Yes	No	0	8	8
189	R:R:F295	R:R:F299	8.57	Yes	Yes	6	8	6
190	R:R:F299	R:R:T298	3.89	Yes	No	0	6	7
191	R:R:I303	R:R:R300	6.26	No	No	0	6	5
192	R:R:R300	R:R:R304	4.26	No	No	0	5	5
193	R:R:K301	R:R:R304	7.43	No	No	0	4	5
194	R:R:L78	R:R:N144	2.75	No	No	0	6	4
195	R:R:L85	R:R:N181	2.75	No	Yes	0	4	5
196	R:R:E228	R:R:L225	2.65	Yes	No	0	7	4
197	R:R:H250	R:R:M177	2.63	No	No	0	6	6
198	R:R:F295	R:R:V31	2.62	Yes	No	0	8	7
199	R:R:S67	R:R:Y271	2.54	No	No	0	3	3
200	R:R:V239	R:R:Y197	2.52	No	Yes	0	8	9
201	R:R:F93	R:R:I92	2.51	No	Yes	0	5	7
202	R:R:F93	R:R:I135	2.51	No	Yes	0	5	4
203	R:R:I108	R:R:R111	2.51	No	No	0	5	5
204	R:R:F257	R:R:M174	2.49	No	No	0	3	4
205	R:R:L115	R:R:R111	2.43	No	No	0	4	5
206	R:R:N113	R:R:Y112	2.33	No	Yes	0	5	7
207	R:R:A126	R:R:G123	1.95	No	No	0	4	3
208	R:R:A243	R:R:G240	1.95	No	No	0	5	5
209	R:R:C259	R:R:P260	1.88	No	No	0	4	1
210	L:L:?1	R:R:M270	1.87	Yes	No	0	0	4
211	R:R:A265	R:R:P266	1.87	No	No	0	4	3
212	R:R:A289	R:R:P285	1.87	No	No	0	7	9
213	R:R:G5	R:R:S6	1.86	No	No	0	5	4
214	R:R:C71	R:R:C74	1.82	No	No	0	2	3
215	R:R:A73	R:R:C71	1.81	No	No	0	7	2
216	R:R:P285	R:R:V27	1.77	No	No	0	9	9
217	R:R:G23	R:R:L22	1.71	No	No	0	9	5
218	R:R:A51	R:R:S90	1.71	No	No	0	8	6
219	R:R:G76	R:R:L78	1.71	No	No	0	6	6
220	R:R:G195	R:R:L194	1.71	No	No	0	4	4
221	R:R:G195	R:R:L198	1.71	No	No	0	4	4
222	R:R:C245	R:R:V283	1.71	No	No	0	8	6
223	R:R:A20	R:R:V282	1.7	No	No	0	7	7
224	R:R:A49	R:R:V27	1.7	No	No	0	9	9
225	R:R:G114	R:R:N113	1.7	No	No	0	5	5
226	R:R:I108	R:R:P109	1.69	No	No	0	5	8
227	R:R:C128	R:R:I125	1.64	No	No	0	7	8
228	R:R:L247	R:R:P248	1.64	No	No	0	6	9
229	R:R:C254	R:R:I251	1.64	No	No	0	6	5
230	R:R:N145	R:R:P173	1.63	No	No	0	4	4
231	R:R:A203	R:R:I106	1.62	No	No	0	6	8
232	R:R:A265	R:R:I252	1.62	No	No	0	4	5
233	R:R:A99	R:R:M193	1.61	No	No	0	9	8
234	R:R:T11	R:R:V12	1.59	No	No	0	4	5
235	R:R:T279	R:R:V283	1.59	No	No	0	5	6
236	R:R:A15	R:R:L19	1.58	No	No	0	5	5
237	R:R:A243	R:R:L247	1.58	No	No	0	5	6
238	R:R:I10	R:R:S7	1.55	No	No	0	6	4
239	R:R:I21	R:R:V25	1.54	No	No	5	6	4
240	R:R:I53	R:R:V25	1.54	No	No	5	7	4
241	R:R:I127	R:R:V130	1.54	No	No	0	3	4
242	R:R:I10	R:R:T11	1.52	No	No	0	6	4
243	R:R:I64	R:R:T65	1.52	No	No	0	6	5
244	R:R:I252	R:R:T256	1.52	No	No	0	5	4
245	R:R:L235	R:R:S234	1.5	No	No	0	8	8
246	R:R:L19	R:R:V18	1.49	No	No	0	5	4
247	R:R:L19	R:R:V282	1.49	No	No	0	5	7
248	R:R:L194	R:R:V239	1.49	No	No	0	4	8
249	R:R:L272	R:R:V275	1.49	No	No	1	5	5
250	R:R:L276	R:R:V275	1.49	No	No	1	7	5
251	R:R:I302	R:R:L26	1.43	No	No	0	6	6
252	R:R:I302	R:R:L33	1.43	No	No	0	6	5
253	R:R:M177	R:R:N253	1.4	No	No	0	6	5
254	R:R:L190	R:R:L191	1.38	No	No	0	6	3
255	R:R:L241	R:R:L244	1.38	No	No	0	7	5
256	R:R:E228	R:R:L208	1.33	Yes	No	0	7	5
257	R:R:F286	R:R:V283	1.31	No	No	0	6	6
258	R:R:I104	R:R:Y112	1.21	No	Yes	0	5	7
259	R:R:E294	R:R:R293	1.16	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.555	6	1	0
2	R:R:F44	3.61333	6	0	7
3	R:R:L48	5.34	4	2	9
4	R:R:D52	7.4875	4	2	9
5	R:R:I60	4.768	5	1	6
6	R:R:F83	6.746	5	7	5
7	R:R:V86	3.72	4	0	4
8	R:R:L87	5.5275	4	0	7
9	R:R:Q89	5.6825	4	3	5
10	R:R:I92	4.902	5	8	7
11	R:R:I98	5.6175	4	2	8
12	R:R:Y112	5.018	5	0	7
13	R:R:I135	4.52	4	3	4
14	R:R:Y176	5.8575	4	0	6
15	R:R:N181	7.12	5	3	5
16	R:R:Y197	4.1075	4	0	9
17	R:R:R205	7.7325	4	4	5
18	R:R:E228	5.712	5	4	7
19	R:R:F242	6.27	4	8	9
20	R:R:W246	9.2275	4	8	8
21	R:R:L249	5.76	4	1	5
22	R:R:H278	6.658	5	1	6
23	R:R:N284	6.735	4	2	9
24	R:R:Y288	5.638	5	2	9
25	R:R:F295	8.256	5	6	8
26	R:R:F299	5.1375	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M270	32.9991	1.87	Yes	No	0	0	4
2	R:R:I252	R:R:M270	31.5358	2.92	No	No	0	5	4
3	R:R:A265	R:R:I252	28.3924	1.62	No	No	0	4	5
4	R:R:A265	R:R:P266	26.7191	1.87	No	No	0	4	3
5	R:R:P266	R:R:W268	25.0322	6.76	No	No	0	3	1
6	R:R:W268	R:R:Y9	21.6178	3.86	No	No	0	1	5
7	R:R:Y271	R:R:Y9	19.8903	3.97	No	No	0	3	5
8	R:R:S67	R:R:Y271	14.6196	2.54	No	No	0	3	3
9	R:R:I64	R:R:S67	12.8447	4.64	No	No	0	6	3
10	L:L:?1	R:R:H278	13.6712	8.49	Yes	Yes	1	0	6
11	R:R:H278	R:R:I60	10.0603	7.95	Yes	Yes	1	6	6
12	L:L:?1	R:R:T88	57.11	3.89	Yes	No	0	0	6
13	R:R:T88	R:R:W246	58.2887	4.85	No	Yes	0	6	8
14	R:R:N280	R:R:W246	97.8389	11.3	No	Yes	0	9	8
15	R:R:C245	R:R:N280	19.2331	9.45	No	No	0	8	9
16	R:R:C245	R:R:V283	17.3701	1.71	No	No	0	8	6
17	R:R:T279	R:R:V283	13.6034	1.59	No	No	0	5	6
18	R:R:N280	R:R:N284	100	9.54	No	Yes	0	9	9
19	R:R:D52	R:R:N284	10.2906	5.39	Yes	Yes	2	9	9
20	R:R:G56	R:R:I60	18.5963	3.53	No	Yes	0	7	6
21	R:R:G56	R:R:V55	19.6938	3.68	No	No	0	7	6
22	R:R:L87	R:R:V55	34.7808	7.45	Yes	No	0	7	6
23	R:R:F83	R:R:L87	13.495	8.53	Yes	Yes	0	5	7
24	R:R:N284	R:R:P285	30.9125	6.52	Yes	No	0	9	9
25	R:R:P285	R:R:V27	27.4575	1.77	No	No	0	9	9
26	R:R:F299	R:R:V27	23.9347	3.93	Yes	No	0	6	9
27	R:R:F295	R:R:F299	18.6844	8.57	Yes	Yes	6	8	6
28	R:R:L48	R:R:N284	93.2389	5.49	Yes	Yes	2	9	9
29	R:R:I98	R:R:L48	70.7743	2.85	Yes	Yes	2	8	9
30	R:R:F44	R:R:I98	29.4018	3.77	Yes	Yes	0	7	8
31	R:R:D101	R:R:F44	18.3524	3.58	No	Yes	0	9	7
32	R:R:D101	R:R:Y112	12.3975	3.45	No	Yes	0	9	7
33	R:R:L48	R:R:Y288	53.3365	3.52	Yes	Yes	2	9	9
34	R:R:S281	R:R:V55	34.0492	4.85	No	No	0	9	6
35	L:L:?1	R:R:F168	22.8982	24.93	Yes	No	0	0	4
36	R:R:F168	R:R:V172	19.7277	11.8	No	No	0	4	3
37	R:R:V171	R:R:V172	12.8447	3.21	No	No	0	4	3
38	R:R:F70	R:R:V171	11.0494	5.24	No	No	0	7	4
39	R:R:L87	R:R:V86	30.2757	2.98	Yes	Yes	0	7	4
40	R:R:L137	R:R:V86	18.1898	2.98	No	Yes	0	3	4
41	R:R:L137	R:R:M140	12.0656	4.24	No	No	0	3	5
42	R:R:I92	R:R:W246	71.1469	11.74	Yes	Yes	8	7	8
43	R:R:F93	R:R:I92	69.0062	2.51	No	Yes	0	5	7
44	R:R:F93	R:R:I135	65.6121	2.51	No	Yes	0	5	4
45	R:R:G136	R:R:I135	13.9083	3.53	No	Yes	0	6	4
46	R:R:I135	R:R:Q89	36.6777	5.49	Yes	Yes	3	4	5
47	R:R:C185	R:R:I135	33.8324	6.55	No	Yes	3	5	4
48	R:R:C185	R:R:N181	32.3962	4.72	No	Yes	3	5	5
49	R:R:I98	R:R:R102	52.0832	3.76	Yes	No	2	8	9
50	R:R:R102	R:R:Y197	97.7847	3.09	No	Yes	0	9	9
51	R:R:V196	R:R:Y197	32.3284	3.79	No	Yes	0	7	9
52	R:R:V196	R:R:Y103	29.6863	10.09	No	No	0	7	8
53	R:R:R107	R:R:Y103	24.3005	11.32	No	No	9	6	8
54	R:R:R102	R:R:Y288	47.8626	3.09	No	Yes	2	9	9
55	R:R:L235	R:R:Y197	13.7863	7.03	No	Yes	0	8	9
56	R:R:I108	R:R:R107	21.672	3.76	No	No	0	5	6
57	R:R:I108	R:R:R111	16.2658	2.51	No	No	0	5	5
58	R:R:L115	R:R:R111	13.5424	2.43	No	No	0	4	5
59	R:R:L115	R:R:R120	10.8055	3.64	No	No	0	4	5
60	R:R:N181	R:R:Q89	32.9923	5.28	Yes	Yes	3	5	5
61	R:R:N181	R:R:Y176	18.9079	11.63	Yes	Yes	0	5	6
62	R:R:M177	R:R:N181	43.1475	11.22	No	Yes	0	6	5
63	R:R:M177	R:R:N253	26.6107	1.4	No	No	0	6	5
64	R:R:N253	R:R:V178	23.5621	4.43	No	No	0	5	5
65	R:R:F257	R:R:V178	13.4408	14.42	No	No	0	3	5
66	R:R:F180	R:R:Y176	10.5413	5.16	No	Yes	0	4	6
67	R:R:H250	R:R:M177	13.6712	2.63	No	No	0	6	6
68	R:R:V239	R:R:Y197	55.1995	2.52	No	Yes	0	8	9
69	R:R:L194	R:R:V239	42.5107	1.49	No	No	0	4	8
70	R:R:G195	R:R:L194	39.9228	1.71	No	No	0	4	4
71	R:R:G195	R:R:L198	37.3213	1.71	No	No	0	4	4
72	R:R:L198	R:R:L202	34.7063	4.15	No	No	0	4	4
73	R:R:L202	R:R:R205	32.0778	3.64	No	Yes	0	4	5
74	R:R:E228	R:R:R205	18.7928	10.47	Yes	Yes	4	7	5
75	R:R:G240	R:R:V239	11.0765	3.68	No	No	0	5	8
76	R:R:D52	R:R:S281	34.2524	2.94	Yes	No	0	9	9
77	R:R:G136	R:R:V86	14.1657	3.68	No	Yes	0	6	4
78	R:R:D52	R:R:L48	31.3664	9.5	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T88	3.89	1	Yes	No	0	6	0	1
L:L:?1	R:R:F168	24.93	1	Yes	No	0	4	0	1
L:L:?1	R:R:L249	10.96	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I274	13.19	1	Yes	No	0	4	0	1
L:L:?1	R:R:H278	8.49	1	Yes	Yes	0	6	0	1
R:R:E13	R:R:I60	4.1	1	No	Yes	6	6	2	2
R:R:E13	R:R:H278	8.62	1	No	Yes	6	6	2	1
R:R:H278	R:R:I60	7.95	1	Yes	Yes	6	6	1	2
R:R:A63	R:R:H278	2.93	0	No	Yes	5	6	2	1
R:R:A81	R:R:F168	2.77	0	No	No	5	4	2	1
R:R:T88	R:R:W246	4.85	0	No	Yes	6	8	1	2
R:R:F168	R:R:V172	11.8	0	No	No	4	3	1	2
R:R:A273	R:R:L249	4.73	0	No	Yes	6	5	2	1
R:R:I274	R:R:L249	2.85	1	No	Yes	4	5	1	1
R:R:L249	R:R:S277	4.5	1	Yes	No	5	7	1	2
R:R:I252	R:R:M270	2.92	0	No	No	5	4	2	1
R:R:H278	R:R:I274	5.3	1	Yes	No	6	4	1	1
L:L:?1	R:R:M270	1.87	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EE9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	249
Number of Links	259
Number of Hubs	26
Number of Links mediated by Hubs	97
Number of Communities	9
Number of Nodes involved in Communities	38
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	35045
Length Of Smallest Path	3
Average Path Length	13.6774
Length of Longest Path	31
Minimum Path Strength	1.45
Average Path Strength	5.36709
Maximum Path Strength	19.06
Minimum Path Correlation	0.7
Average Path Correlation	0.931204
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	49.7855
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.6006
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADN
Name	Adenosine
Synonyms	Ado
Identifier
Formula	C10 H13 N5 O4
Molecular Weight	267.241
SMILES
PubChem	60961
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	4
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29274
Sequence	>9EE9_nogp_Chain_R G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N S N L Q N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G F C A A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I P L R Y N G L V T G T R A K G I I A I C W V L S F A I G L T P M L G W N N C G L F E D V V P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S T L Q K E H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P D C S H A P L W L M Y L A I V L S H T N S V V N P F I Y A Y I R E F R Q T F R K I I R S H V C A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ZDR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	HMS1413f12	Na	-	1.92	2020-09-16	doi.org/10.1002/anie.202003788
	6ZDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Chromone 5d	Na	-	2.13	2020-09-16	doi.org/10.1002/anie.202003788
	8JWZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	AB928	Na	-	2.37	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	5MZJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	2	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5MZP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	Na	-	2.1	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5N2R	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-36	Na	-	2.8	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	7ARO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5833	Na	-	3.12	2021-04-07	doi.org/10.1021/acs.jmedchem.0c01856
	8CU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	Na	-	2.05	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	5IU4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.72	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456346	Na	-	1.9	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456347	Na	-	2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456348	Na	-	2.2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456344	Na	-	2.1	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5VRA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.35	2017-12-13	doi.org/10.1038/nprot.2017.135
	5NLX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.14	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	8FYN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2023-03-08	doi.org/10.1038/s41467-023-36733-4
	8RW0	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	1.94	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	5OLG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.87	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Vipadenant	Na	-	2.6	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Tozadenant	Na	-	3.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA41063	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	1.9	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM1	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	6LPJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPL	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	8CIC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	Na	-	2.1	2023-05-31	doi.org/10.1038/s42004-023-00894-6
	7RM5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.79	2021-09-08	doi.org/10.1073/pnas.2106041118
	6JZH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.25	2019-10-30	doi.org/10.1107/S1600576719012846
	8A2O	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	3.45	2023-08-30	doi.org/10.1107/S1600576723006428
	8A2P	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA47070	Na	-	3.5	2023-08-30	doi.org/10.1107/S1600576723006428
	6PS7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.85	2019-11-13	doi.org/10.1107/S2052252519013137
	6WQA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-18	doi.org/10.1107/S2052252520012701
	8GNE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	KW-6356	Na	-	2.3	2023-03-22	doi.org/10.1124/molpharm.122.000633
	5K2A	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2B	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2C	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2D	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	4EIY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2012-07-25	doi.org/10.1126/science.1219218
	6GT3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Imaradenant	Na	-	2	2019-06-26	doi.org/10.1136/jitc-2019-000417
	8RQQ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.37	2024-04-03	doi.org/10.1021/acs.cgd.4c00087
	8RVW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.65	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	AzoSwitch2	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch1	Na	-	2.25	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.31	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWD	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch4	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.45	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.8	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	3.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	9FUP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	2.5	2025-01-22	doi.org/10.1038/s42004-024-01404-y
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR1	Na	-	1.75	2025-06-18	To be published
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	3VG9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	2.7	2012-02-01	doi.org/10.1038/nature10750
	3VGA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	3.1	2012-02-01	doi.org/10.1038/nature10750
	7PX4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2113	-	-	2.25	2022-03-02	doi.org/10.1002/anie.202115545
	7PYR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2115	-	-	2.6	2022-03-02	doi.org/10.1002/anie.202115545
	8JWY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	2-118	-	-	2.33	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	6AQF	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.51	2018-01-10	doi.org/10.1016/j.cell.2017.12.004
	8DU3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 105526064	-	-	2.5	2022-08-10	doi.org/10.1016/j.ejmech.2022.114620
	3PWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.3	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3REY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	XAC	-	-	3.31	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3RFM	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	-	-	3.6	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	5WF5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.6	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	5WF6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.9	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	8CU6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	-	-	2.8	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	3UZA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	GTPL9236	-	-	3.27	2012-03-21	doi.org/10.1021/jm201376w
	3UZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	-	-	3.34	2012-03-21	doi.org/10.1021/jm201376w
	2YDO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	-	3	2011-05-18	doi.org/10.1038/nature10136
	2YDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	-	2.6	2011-05-18	doi.org/10.1038/nature10136
	5G53	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs	3.4	2016-08-03	doi.org/10.1038/nature18966
	5G53 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		3.4	2016-08-03	doi.org/10.1038/nature18966
	7T32	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.4	2022-08-10	doi.org/10.1038/s41467-022-32125-2
	8C9W	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	-	-	2.11	2023-07-12	doi.org/10.1038/s42004-023-00894-6
	8PWN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	-	-	2.75	2023-10-25	doi.org/10.1038/s42004-023-01014-0
	5UIG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Cmpd-1	-	-	3.5	2017-02-08	doi.org/10.1073/pnas.1621423114
	5UVI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.2	2017-05-24	doi.org/10.1107/S205225251700570X
	6MH8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	4.2	2019-04-24	doi.org/10.1107/S205225251900263X
	6S0L	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	6S0Q	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	7EZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UKA	-	-	3.8	2022-04-13	doi.org/10.1107/S2052252522001907
	4UG2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	4UHR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	8GNG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	-	-	3.2	2023-03-22	doi.org/10.1124/molpharm.122.000633
	5JTB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.8	2017-05-31	doi.org/10.1126/sciadv.1602952
	3EML	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.6	2008-10-14	doi.org/10.1126/science.1164772
	3QAK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.71	2011-03-09	doi.org/10.1126/science.1202793
	6GDG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs/β1/γ1	4.11	2018-05-16	doi.org/10.7554/eLife.35946
	6GDG (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		4.11	2018-05-16	doi.org/10.7554/eLife.35946
	8WDT	A	Nucleotide	Adenosine	A_2A	Homo sapiens	photoNECA	-	-	3.34	2024-01-17	doi.org/10.1016/j.bbrc.2023.149393
	8RLN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5834	-	-	2.43	2024-06-19	doi.org/10.1021/acsptsci.4c00051
	9EE8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE8 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	8UGW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 3086599	-	-	3.9	2024-12-18	doi.org/10.1038/s41557-024-01719-2

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