psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H176	R:R:S7	4.18	Yes	No	0	4	5
2	R:R:E259	R:R:S7	10.06	Yes	No	0	2	5
3	R:R:E259	R:R:M9	5.41	Yes	Yes	1	2	1
4	R:R:H268	R:R:M9	19.7	No	Yes	1	2	1
5	R:R:M9	R:R:Q269	8.16	Yes	No	0	1	2
6	R:R:D10	R:R:R14	10.72	Yes	Yes	1	6	4
7	R:R:D10	R:R:Y15	10.34	Yes	Yes	1	6	5
8	R:R:D10	R:R:R172	8.34	Yes	Yes	1	6	4
9	R:R:D10	R:R:H176	11.35	Yes	Yes	1	6	4
10	R:R:F13	R:R:S11	10.57	Yes	Yes	1	6	7
11	R:R:R14	R:R:S11	5.27	Yes	Yes	1	4	7
12	R:R:N272	R:R:S11	4.47	No	Yes	1	4	7
13	R:R:Q276	R:R:S11	4.33	Yes	Yes	1	4	7
14	R:R:F13	R:R:L17	3.65	Yes	No	0	6	5
15	R:R:D273	R:R:F13	9.55	No	Yes	0	1	6
16	R:R:F13	R:R:Q276	5.86	Yes	Yes	1	6	4
17	R:R:R14	R:R:Y15	16.46	Yes	Yes	1	4	5
18	R:R:R14	R:R:Y77	5.14	Yes	Yes	1	4	6
19	R:R:E175	R:R:R14	11.63	No	Yes	1	4	4
20	R:R:H176	R:R:R14	5.64	Yes	Yes	1	4	4
21	R:R:Q276	R:R:R14	5.84	Yes	Yes	1	4	4
22	R:R:Q80	R:R:Y15	6.76	No	Yes	0	3	5
23	R:R:G81	R:R:Y15	5.79	No	Yes	0	5	5
24	R:R:R172	R:R:Y15	5.14	Yes	Yes	1	4	5
25	R:R:F18	R:R:L17	4.87	Yes	No	0	5	5
26	R:R:F18	R:R:Y22	7.22	Yes	Yes	0	5	8
27	R:R:F18	R:R:Y77	17.54	Yes	Yes	0	5	6
28	R:R:F18	R:R:Q276	7.03	Yes	Yes	0	5	4
29	R:R:F18	R:R:L279	3.65	Yes	No	0	5	6
30	R:R:L70	R:R:Y22	8.21	No	Yes	0	8	8
31	R:R:I74	R:R:Y22	4.84	No	Yes	0	8	8
32	R:R:S283	R:R:Y22	7.63	No	Yes	0	7	8
33	R:R:I24	R:R:L28	4.28	No	No	0	4	6
34	R:R:F26	R:R:P71	7.22	No	No	0	7	8
35	R:R:G29	R:R:L67	5.13	No	No	0	8	6
36	R:R:N33	R:R:T60	5.85	No	No	0	9	9
37	R:R:D63	R:R:N33	4.04	No	No	0	9	9
38	R:R:M64	R:R:N33	7.01	No	No	0	7	9
39	R:R:H303	R:R:Y35	4.36	Yes	No	3	4	5
40	R:R:L304	R:R:Y35	3.52	No	No	0	6	5
41	R:R:K307	R:R:Y35	4.78	No	No	3	3	5
42	R:R:T60	R:R:V36	7.93	No	No	0	9	8
43	R:R:C294	R:R:V36	5.12	No	No	0	7	8
44	R:R:F295	R:R:V36	3.93	Yes	No	0	7	8
45	R:R:L37	R:R:T60	5.9	No	No	0	7	9
46	R:R:R42	R:R:W38	15.99	No	No	0	5	4
47	R:R:F300	R:R:V39	10.49	No	No	0	8	7
48	R:R:F40	R:R:Y44	7.22	No	Yes	0	7	5
49	R:R:F40	R:R:M56	6.22	No	No	0	7	8
50	R:R:L43	R:R:Y44	15.24	No	Yes	0	5	5
51	R:R:K299	R:R:L43	7.05	Yes	No	0	6	5
52	R:R:K48	R:R:Y44	3.58	No	Yes	4	6	5
53	R:R:K53	R:R:Y44	10.75	No	Yes	4	7	5
54	R:R:K48	R:R:P45	5.02	No	No	0	6	4
55	R:R:K48	R:R:K53	4.31	No	No	4	6	7
56	R:R:K53	R:R:N50	4.2	No	No	0	7	7
57	R:R:E51	R:R:F55	10.49	Yes	Yes	2	6	7
58	R:R:E51	R:R:N114	10.52	Yes	No	2	6	8
59	R:R:E51	R:R:T130	12.7	Yes	No	0	6	6
60	R:R:E51	R:R:R133	6.98	Yes	No	0	6	3
61	R:R:E51	R:R:G134	8.19	Yes	No	0	6	8
62	R:R:I135	R:R:I54	5.89	No	No	0	3	7
63	R:R:F107	R:R:F55	4.29	Yes	Yes	2	8	7
64	R:R:F55	R:R:V110	13.11	Yes	No	0	7	7
65	R:R:F55	R:R:I111	5.02	Yes	No	0	7	8
66	R:R:F55	R:R:N114	4.83	Yes	No	2	7	8
67	R:R:C294	R:R:M56	3.24	No	No	0	7	8
68	R:R:F107	R:R:N58	12.08	Yes	Yes	2	8	9
69	R:R:N58	R:R:S138	8.94	Yes	No	2	9	7
70	R:R:N58	R:R:W142	4.52	Yes	No	2	9	9
71	R:R:L59	R:R:S104	4.5	No	No	0	9	9
72	R:R:L108	R:R:L59	8.3	No	No	0	9	9
73	R:R:C286	R:R:D63	6.22	No	No	0	8	9
74	R:R:L65	R:R:N100	6.87	No	No	0	6	8
75	R:R:F66	R:R:L70	8.53	Yes	No	0	7	8
76	R:R:F66	R:R:F97	12.86	Yes	Yes	0	7	7
77	R:R:F66	R:R:N100	4.83	Yes	No	0	7	8
78	R:R:F66	R:R:S283	3.96	Yes	No	0	7	7
79	R:R:C286	R:R:F66	6.98	No	Yes	0	8	7
80	R:R:L96	R:R:T69	7.37	No	No	0	5	6
81	R:R:L72	R:R:L89	6.92	No	Yes	0	6	5
82	R:R:W73	R:R:Y76	4.82	Yes	Yes	1	7	6
83	R:R:W73	R:R:Y77	4.82	Yes	Yes	1	7	6
84	R:R:G94	R:R:W73	5.63	No	Yes	0	5	7
85	R:R:F97	R:R:W73	4.01	Yes	Yes	1	7	7
86	R:R:C173	R:R:W73	6.53	Yes	Yes	1	9	7
87	L:L:?1	R:R:W73	14.04	Yes	Yes	1	0	7
88	R:R:Y76	R:R:Y77	7.94	Yes	Yes	1	6	6
89	R:R:G81	R:R:Y76	10.14	No	Yes	0	5	6
90	R:R:W83	R:R:Y76	8.68	Yes	Yes	1	8	6
91	R:R:R172	R:R:Y76	4.12	Yes	Yes	1	4	6
92	R:R:C173	R:R:Y76	4.03	Yes	Yes	1	9	6
93	R:R:E175	R:R:Y76	11.22	No	Yes	1	4	6
94	L:L:?1	R:R:Y77	3.94	Yes	Yes	1	0	6
95	R:R:N79	R:R:Q78	6.6	No	No	0	4	4
96	R:R:N82	R:R:V170	4.43	No	No	0	5	3
97	R:R:L85	R:R:W83	6.83	Yes	Yes	1	7	8
98	R:R:L89	R:R:W83	4.56	Yes	Yes	1	5	8
99	R:R:C90	R:R:W83	9.14	No	Yes	1	9	8
100	R:R:C173	R:R:W83	9.14	Yes	Yes	1	9	8
101	R:R:L85	R:R:P86	4.93	Yes	No	0	7	8
102	R:R:L85	R:R:L89	4.15	Yes	Yes	1	7	5
103	R:R:D156	R:R:K87	4.15	No	No	1	5	3
104	R:R:K87	R:R:T158	9.01	No	No	1	3	5
105	R:R:F88	R:R:V92	5.24	No	No	0	2	5
106	R:R:C173	R:R:C90	7.28	Yes	No	1	9	9
107	R:R:N91	R:R:S157	5.96	No	No	0	7	5
108	R:R:F174	R:R:G94	9.03	Yes	No	0	4	5
109	R:R:C95	R:R:L153	4.76	No	No	0	6	5
110	R:R:F97	R:R:F98	4.29	Yes	No	1	7	5
111	L:L:?1	R:R:F97	5.46	Yes	Yes	1	0	7
112	R:R:F98	R:R:Y102	5.16	No	Yes	1	5	8
113	L:L:?1	R:R:F98	21.84	Yes	No	1	0	5
114	R:R:T101	R:R:Y102	8.74	No	Yes	0	8	8
115	R:R:I191	R:R:Y102	15.71	No	Yes	1	6	8
116	R:R:H249	R:R:Y102	6.53	Yes	Yes	1	8	8
117	R:R:Q252	R:R:Y102	3.38	Yes	Yes	1	7	8
118	L:L:?1	R:R:Y102	5.91	Yes	Yes	1	0	8
119	R:R:C103	R:R:F107	5.59	No	Yes	2	7	8
120	R:R:C103	R:R:W142	5.22	No	No	2	7	9
121	R:R:F245	R:R:V105	3.93	No	No	0	8	7
122	R:R:F107	R:R:S138	5.28	Yes	No	2	8	7
123	R:R:F107	R:R:W142	8.02	Yes	No	2	8	9
124	R:R:D289	R:R:L108	4.07	No	No	0	9	9
125	R:R:L108	R:R:Y293	8.21	No	Yes	0	9	9
126	R:R:G109	R:R:I202	3.53	No	Yes	0	8	7
127	R:R:I111	R:R:R115	3.76	No	No	0	8	9
128	R:R:I202	R:R:T112	10.64	Yes	No	0	7	9
129	R:R:Q117	R:R:Y113	18.04	No	No	0	6	6
130	R:R:R115	R:R:Y293	7.2	No	Yes	0	9	9
131	R:R:F116	R:R:T120	10.38	Yes	No	0	8	8
132	R:R:C205	R:R:F116	9.78	Yes	Yes	0	7	8
133	R:R:F116	R:R:V208	7.87	Yes	No	0	8	3
134	R:R:A118	R:R:T125	3.36	No	No	0	8	6
135	R:R:I209	R:R:V119	7.68	No	No	0	8	8
136	R:R:R121	R:R:T120	3.88	No	No	0	7	8
137	R:R:K124	R:R:R121	8.66	No	No	0	4	7
138	R:R:I123	R:R:K124	4.36	No	No	0	6	4
139	R:R:I123	R:R:Q127	4.12	No	No	0	6	4
140	R:R:L137	R:R:R133	3.64	No	No	0	5	3
141	R:R:G147	R:R:S150	3.71	No	No	0	3	4
142	R:R:F152	R:R:Y151	6.19	No	No	0	5	7
143	R:R:L155	R:R:Y151	3.52	No	No	0	5	7
144	R:R:P183	R:R:Y151	6.95	No	No	0	3	7
145	R:R:F152	R:R:I187	12.56	No	No	1	5	5
146	L:L:?1	R:R:F152	4.78	Yes	No	1	0	5
147	R:R:D156	R:R:T158	7.23	No	No	1	5	5
148	R:R:F174	R:R:S157	6.61	Yes	No	1	4	5
149	R:R:S157	R:R:Y177	3.82	No	Yes	1	5	6
150	R:R:P162	R:R:V161	3.53	No	No	0	2	1
151	R:R:R172	R:R:V161	5.23	Yes	No	0	4	1
152	R:R:R172	R:R:V170	5.23	Yes	No	0	4	3
153	R:R:H176	R:R:R172	10.16	Yes	Yes	1	4	4
154	R:R:F174	R:R:Y177	7.22	Yes	Yes	1	4	6
155	L:L:?1	R:R:F174	8.87	Yes	Yes	1	0	4
156	R:R:E175	R:R:H176	9.85	No	Yes	1	4	4
157	R:R:V184	R:R:Y177	5.05	Yes	Yes	1	3	6
158	L:L:?1	R:R:Y177	11.83	Yes	Yes	1	0	6
159	R:R:G180	R:R:L260	3.42	No	Yes	1	1	1
160	R:R:F262	R:R:G180	4.52	Yes	No	1	1	1
161	R:R:P183	R:R:V182	3.53	No	No	0	3	1
162	L:L:?1	R:R:V184	3.34	Yes	Yes	1	0	3
163	R:R:I189	R:R:L185	7.14	No	Yes	0	4	4
164	R:R:L185	R:R:L257	4.15	Yes	No	0	4	4
165	R:R:L185	R:R:L260	4.15	Yes	Yes	1	4	1
166	R:R:F262	R:R:L185	7.31	Yes	Yes	1	1	4
167	L:L:?1	R:R:I187	10.4	Yes	No	1	0	5
168	R:R:H188	R:R:Q252	8.65	No	Yes	0	4	7
169	R:R:H188	R:R:T256	15.06	No	No	0	4	5
170	L:L:?1	R:R:H188	15.85	Yes	No	0	0	4
171	R:R:F193	R:R:I189	6.28	No	No	0	4	4
172	R:R:F190	R:R:I191	3.77	No	No	1	5	6
173	R:R:F190	R:R:S194	7.93	No	No	1	5	6
174	L:L:?1	R:R:F190	7.51	Yes	No	1	0	5
175	L:L:?1	R:R:I191	7.2	Yes	No	1	0	6
176	L:L:?1	R:R:S194	4.21	Yes	No	1	0	6
177	R:R:F195	R:R:F196	5.36	No	No	0	9	5
178	R:R:F195	R:R:F241	5.36	No	Yes	0	9	9
179	R:R:F195	R:R:H249	30.55	No	Yes	0	9	8
180	R:R:F199	R:R:L203	4.87	Yes	No	0	6	4
181	R:R:F199	R:R:F241	4.29	Yes	Yes	0	6	9
182	R:R:F199	R:R:I242	5.02	Yes	No	6	6	5
183	R:R:F199	R:R:V246	3.93	Yes	Yes	6	6	6
184	R:R:I202	R:R:N206	4.25	Yes	Yes	0	7	9
185	R:R:F241	R:R:I202	3.77	Yes	Yes	0	9	7
186	R:R:L203	R:R:L207	8.3	No	No	0	4	3
187	R:R:F204	R:R:V208	7.87	No	No	0	5	3
188	R:R:N206	R:R:V234	5.91	Yes	No	0	9	8
189	R:R:L238	R:R:N206	13.73	No	Yes	0	8	9
190	R:R:I210	R:R:L231	4.28	No	Yes	0	5	5
191	R:R:L213	R:R:L231	4.15	Yes	Yes	0	8	5
192	R:R:L214	R:R:L231	9.69	No	Yes	0	4	5
193	R:R:K227	R:R:Q221	9.49	No	No	0	6	4
194	R:R:N223	R:R:V226	8.87	No	No	0	4	5
195	R:R:K227	R:R:N223	5.6	No	No	0	6	4
196	R:R:E225	R:R:R228	12.79	No	No	0	4	5
197	R:R:R229	R:R:R301	9.6	No	No	0	7	8
198	R:R:L231	R:R:W232	3.42	Yes	No	0	5	5
199	R:R:I292	R:R:V237	4.61	No	No	5	7	8
200	R:R:V237	R:R:Y293	6.31	No	Yes	5	8	9
201	R:R:I242	R:R:L238	7.14	No	No	0	5	8
202	R:R:I292	R:R:V240	4.61	No	No	0	7	6
203	R:R:F241	R:R:F245	16.08	Yes	No	0	9	8
204	R:R:I242	R:R:V246	4.61	No	Yes	6	5	6
205	R:R:C244	R:R:N285	9.45	No	No	0	8	9
206	R:R:F245	R:R:N285	14.5	No	No	0	8	9
207	R:R:P247	R:R:V246	3.53	No	Yes	0	9	6
208	R:R:H248	R:R:H249	10.75	Yes	Yes	1	7	8
209	R:R:H248	R:R:Q252	18.54	Yes	Yes	1	7	7
210	R:R:H248	R:R:H275	5.97	Yes	Yes	1	7	5
211	R:R:H248	R:R:T278	6.85	Yes	Yes	1	7	7
212	R:R:H248	R:R:L279	3.86	Yes	No	0	7	6
213	R:R:H248	R:R:L282	15.43	Yes	No	0	7	8
214	R:R:H249	R:R:Q252	3.71	Yes	Yes	1	8	7
215	R:R:A274	R:R:V251	3.39	No	No	0	5	5
216	R:R:H275	R:R:V251	6.92	Yes	No	1	5	5
217	R:R:T278	R:R:V251	4.76	Yes	No	1	7	5
218	R:R:L253	R:R:P254	4.93	No	No	0	6	5
219	R:R:L253	R:R:L257	5.54	No	No	0	6	4
220	R:R:T256	R:R:W255	3.64	No	Yes	0	5	5
221	R:R:E259	R:R:W255	13.08	Yes	Yes	1	2	5
222	R:R:H275	R:R:W255	24.33	Yes	Yes	1	5	5
223	L:L:?1	R:R:W255	12.77	Yes	Yes	1	0	5
224	R:R:L257	R:R:Q263	9.32	No	No	0	4	1
225	R:R:A258	R:R:H268	7.32	No	No	0	4	2
226	R:R:E259	R:R:H268	11.08	Yes	No	1	2	2
227	R:R:F262	R:R:L260	7.31	Yes	Yes	1	1	1
228	R:R:F262	R:R:Q263	4.68	Yes	No	0	1	1
229	R:R:F267	R:R:K266	17.37	No	No	0	1	1
230	R:R:D273	R:R:N272	4.04	No	No	0	1	4
231	R:R:N272	R:R:Q276	6.6	No	Yes	1	4	4
232	R:R:H275	R:R:Q276	3.71	Yes	Yes	1	5	4
233	R:R:H275	R:R:T278	5.48	Yes	Yes	1	5	7
234	L:L:?1	R:R:H275	4.32	Yes	Yes	1	0	5
235	R:R:D289	R:R:N285	13.46	No	No	0	9	9
236	R:R:F295	R:R:V291	7.87	Yes	No	0	7	6
237	R:R:I292	R:R:Y293	3.63	No	Yes	5	7	9
238	R:R:C294	R:R:F300	5.59	No	No	0	7	8
239	R:R:F295	R:R:F300	6.43	Yes	No	0	7	8
240	R:R:L296	R:R:R301	3.64	No	No	0	7	8
241	R:R:K298	R:R:T297	4.5	No	No	0	5	8
242	R:R:H303	R:R:K299	11.79	Yes	Yes	0	4	6
243	R:R:H303	R:R:K307	17.03	Yes	No	3	4	3
244	R:R:F308	R:R:L304	3.65	No	No	0	5	6
245	R:R:S181	R:R:V184	3.23	No	Yes	0	4	3
246	R:R:D63	R:R:P290	3.22	No	No	0	9	9
247	R:R:F49	R:R:R131	3.21	No	No	0	5	2
248	R:R:C280	R:R:L17	3.17	No	No	0	6	5
249	R:R:H303	R:R:W38	3.17	Yes	No	0	4	4
250	R:R:C286	R:R:L67	3.17	No	No	0	8	6
251	R:R:T212	R:R:V119	3.17	No	No	0	5	8
252	R:R:C235	R:R:L231	3.17	No	Yes	0	4	5
253	R:R:P217	R:R:Q221	3.16	No	No	0	4	4
254	R:R:A93	R:R:L72	3.15	No	No	0	5	6
255	R:R:I25	R:R:S283	3.1	No	No	0	7	7
256	R:R:I25	R:R:V21	3.07	No	No	0	7	6
257	R:R:I25	R:R:V287	3.07	No	No	0	7	8
258	R:R:I31	R:R:V27	3.07	No	No	0	5	5
259	R:R:I186	R:R:V182	3.07	No	No	0	4	1
260	R:R:I202	R:R:V198	3.07	Yes	No	0	7	9
261	R:R:M64	R:R:V30	3.04	No	No	0	7	5
262	R:R:A224	R:R:Q221	3.03	No	No	0	3	4
263	R:R:L28	R:R:V27	2.98	No	No	0	6	5
264	R:R:L28	R:R:V287	2.98	No	No	0	6	8
265	R:R:L89	R:R:V92	2.98	Yes	No	0	5	5
266	R:R:L96	R:R:V92	2.98	No	No	0	5	5
267	R:R:L260	R:R:V184	2.98	Yes	Yes	1	1	3
268	R:R:L253	R:R:V192	2.98	No	No	0	6	5
269	R:R:L288	R:R:V240	2.98	No	No	0	6	6
270	R:R:N159	R:R:V161	2.96	No	No	0	2	1
271	R:R:L281	R:R:T284	2.95	No	No	0	8	5
272	R:R:I145	R:R:I99	2.94	No	No	0	8	5
273	R:R:I141	R:R:I145	2.94	No	No	0	7	8
274	R:R:D163	R:R:S164	2.94	No	No	0	1	1
275	R:R:D163	R:R:V170	2.92	No	No	0	1	3
276	R:R:Q219	R:R:V218	2.87	No	No	0	3	3
277	R:R:I84	R:R:L85	2.85	No	Yes	0	2	7
278	R:R:I135	R:R:L139	2.85	No	No	0	3	3
279	R:R:I209	R:R:L213	2.85	No	Yes	0	8	8
280	R:R:I52	R:R:N114	2.83	No	No	0	7	8
281	R:R:I54	R:R:N58	2.83	No	Yes	0	7	9
282	R:R:I99	R:R:N100	2.83	No	No	0	5	8
283	R:R:K227	R:R:L213	2.82	No	Yes	0	6	8
284	R:R:C95	R:R:F174	2.79	No	Yes	0	6	4
285	R:R:P19	R:R:Y77	2.78	No	Yes	0	5	6
286	R:R:A32	R:R:F295	2.77	No	Yes	0	7	7
287	R:R:C205	R:R:Y113	2.69	Yes	No	0	7	6
288	R:R:E178	R:R:N159	2.63	No	No	0	3	2
289	R:R:F116	R:R:I209	2.51	Yes	No	0	8	8
290	R:R:F267	R:R:I271	2.51	No	No	0	1	4
291	R:R:F26	R:R:L67	2.44	No	No	0	7	6
292	R:R:N129	R:R:R131	2.41	No	No	0	6	2
293	R:R:F49	R:R:Y44	2.06	No	Yes	0	5	5
294	R:R:R228	R:R:W232	2	No	No	0	5	5
295	R:R:A165	R:R:G166	1.95	No	No	0	2	1
296	R:R:A165	R:R:G168	1.95	No	No	0	2	3
297	R:R:A62	R:R:C103	1.81	No	No	0	8	7
298	R:R:A149	R:R:C95	1.81	No	No	0	7	6
299	R:R:G34	R:R:M64	1.75	No	No	0	4	7
300	R:R:G180	R:R:K179	1.74	No	No	0	1	3
301	R:R:C90	R:R:T158	1.69	No	No	1	9	5
302	R:R:I123	R:R:P122	1.69	No	No	0	6	8
303	R:R:C244	R:R:T284	1.69	No	No	0	8	5
304	R:R:D163	R:R:G168	1.68	No	No	0	1	3
305	R:R:C205	R:R:I201	1.64	Yes	No	0	7	6
306	R:R:C46	R:R:K47	1.62	No	No	0	4	5
307	R:R:A106	R:R:I141	1.62	No	No	0	6	7
308	R:R:S136	R:R:V140	1.62	No	No	0	2	4
309	R:R:S150	R:R:V146	1.62	No	No	0	4	4
310	R:R:V246	R:R:V250	1.6	Yes	No	0	6	6
311	R:R:T236	R:R:V240	1.59	No	No	0	6	6
312	R:R:T278	R:R:V277	1.59	Yes	No	0	7	6
313	R:R:A230	R:R:L213	1.58	No	Yes	0	7	8
314	R:R:P217	R:R:Q216	1.58	No	No	0	4	5
315	R:R:T160	R:R:T171	1.57	No	No	0	4	5
316	R:R:C205	R:R:N206	1.57	Yes	Yes	0	7	9
317	R:R:I20	R:R:S23	1.55	No	No	0	5	5
318	R:R:I24	R:R:S23	1.55	No	No	0	4	5
319	R:R:I74	R:R:S23	1.55	No	No	0	8	5
320	R:R:K302	R:R:T305	1.5	No	No	0	3	4
321	R:R:L37	R:R:V57	1.49	No	No	0	7	5
322	R:R:N79	R:R:V75	1.48	No	No	0	4	4
323	R:R:N82	R:R:T171	1.46	No	No	0	5	5
324	R:R:N159	R:R:T160	1.46	No	No	0	2	4
325	R:R:Q263	R:R:S265	1.44	No	No	0	1	7
326	R:R:K298	R:R:K299	1.44	No	Yes	0	5	6
327	R:R:K299	R:R:K302	1.44	Yes	No	0	6	3
328	R:R:I243	R:R:L281	1.43	No	No	0	6	8
329	R:R:I84	R:R:N79	1.42	No	No	0	2	4
330	R:R:Q117	R:R:T125	1.42	No	No	0	6	6
331	R:R:K132	R:R:N129	1.4	No	No	0	4	6
332	R:R:A270	R:R:F267	1.39	No	No	0	3	1
333	R:R:H8	R:R:M9	1.31	No	Yes	0	6	1
334	R:R:R211	R:R:V208	1.31	No	No	0	4	3
335	R:R:F13	R:R:T16	1.3	Yes	No	0	6	5
336	R:R:F26	R:R:I68	1.26	No	No	0	7	5
337	R:R:M233	R:R:R229	1.24	No	No	0	8	7
338	R:R:E306	R:R:H303	1.23	No	Yes	0	4	4
339	R:R:F193	R:R:L197	1.22	No	No	0	4	6
340	R:R:F295	R:R:L296	1.22	Yes	No	0	7	7
341	R:R:I271	R:R:W255	1.17	No	Yes	0	4	5
342	L:L:?1	R:R:A148	0.88	Yes	No	0	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M9	8.645	4	1	1
2	R:R:D10	10.1875	4	1	6
3	R:R:S11	6.16	4	1	7
4	R:R:F13	6.186	5	1	6
5	R:R:R14	8.67143	7	1	4
6	R:R:Y15	8.898	5	1	5
7	R:R:F18	8.062	5	0	5
8	R:R:Y22	6.975	4	0	8
9	R:R:Y44	7.77	5	4	5
10	R:R:E51	9.776	5	2	6
11	R:R:F55	7.548	5	2	7
12	R:R:N58	7.0925	4	2	9
13	R:R:F66	7.432	5	0	7
14	R:R:W73	6.64167	6	1	7
15	R:R:Y76	7.27857	7	1	6
16	R:R:Y77	7.02667	6	1	6
17	R:R:W83	7.67	5	1	8
18	R:R:L85	4.69	4	1	7
19	R:R:L89	4.6525	4	1	5
20	R:R:F97	6.655	4	1	7
21	R:R:Y102	7.57167	6	1	8
22	R:R:F107	7.052	5	2	8
23	R:R:F116	7.635	4	0	8
24	R:R:R172	6.37	6	1	4
25	R:R:C173	6.745	4	1	9
26	R:R:F174	6.904	5	1	4
27	R:R:H176	8.236	5	1	4
28	R:R:Y177	6.98	4	1	6
29	R:R:V184	3.65	4	1	3
30	R:R:L185	5.6875	4	1	4
31	R:R:F199	4.5275	4	6	6
32	R:R:I202	5.052	5	0	7
33	R:R:C205	3.92	4	0	7
34	R:R:N206	6.365	4	0	9
35	R:R:L213	2.85	4	0	8
36	R:R:L231	4.942	5	0	5
37	R:R:F241	7.375	4	0	9
38	R:R:V246	3.4175	4	6	6
39	R:R:H248	10.2333	6	1	7
40	R:R:H249	12.885	4	1	8
41	R:R:Q252	8.57	4	1	7
42	R:R:W255	10.998	5	1	5
43	R:R:E259	9.9075	4	1	2
44	R:R:L260	4.465	4	1	1
45	R:R:F262	5.955	4	1	1
46	R:R:H275	8.455	6	1	5
47	R:R:Q276	5.56167	6	1	4
48	R:R:T278	4.67	4	1	7
49	R:R:Y293	6.3375	4	5	9
50	R:R:F295	4.444	5	0	7
51	R:R:K299	5.43	4	0	6
52	R:R:H303	7.516	5	3	4
53	L:L:?1	8.42059	17	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R172	R:R:Y76	20.9393	4.12	Yes	Yes	1	4	6
2	R:R:F18	R:R:Y22	15.2283	7.22	Yes	Yes	0	5	8
3	R:R:I25	R:R:S283	10.5547	3.1	No	No	0	7	7
4	R:R:C286	R:R:F66	66.3394	6.98	No	Yes	0	8	7
5	R:R:F66	R:R:F97	72.597	12.86	Yes	Yes	0	7	7
6	R:R:F97	R:R:W73	14.8028	4.01	Yes	Yes	1	7	7
7	R:R:W73	R:R:Y76	24.5721	4.82	Yes	Yes	1	7	6
8	L:L:?1	R:R:F97	37.4014	5.46	Yes	Yes	1	0	7
9	L:L:?1	R:R:Y77	22.124	3.94	Yes	Yes	1	0	6
10	R:R:C286	R:R:D63	59.6825	6.22	No	No	0	8	9
11	R:R:D63	R:R:N33	57.4112	4.04	No	No	0	9	9
12	R:R:N33	R:R:T60	52.7901	5.85	No	No	0	9	9
13	R:R:T60	R:R:V36	49.2554	7.93	No	No	0	9	8
14	R:R:C294	R:R:V36	37.061	5.12	No	No	0	7	8
15	R:R:C294	R:R:M56	33.9781	3.24	No	No	0	7	8
16	R:R:F40	R:R:M56	32.6722	6.22	No	No	0	7	8
17	R:R:F40	R:R:Y44	31.3828	7.22	No	Yes	0	7	5
18	R:R:L43	R:R:Y44	19.4731	15.24	No	Yes	0	5	5
19	R:R:K299	R:R:L43	18.0985	7.05	Yes	No	0	6	5
20	R:R:H303	R:R:K299	11.278	11.79	Yes	Yes	0	4	6
21	R:R:F295	R:R:V36	12.1584	3.93	Yes	No	0	7	8
22	R:R:F55	R:R:I111	24.3266	5.02	Yes	No	0	7	8
23	R:R:I111	R:R:R115	25.6161	3.76	No	No	0	8	9
24	R:R:R115	R:R:Y293	26.8205	7.2	No	Yes	0	9	9
25	R:R:L108	R:R:Y293	34.3806	8.21	No	Yes	0	9	9
26	R:R:D289	R:R:L108	38.0723	4.07	No	No	0	9	9
27	R:R:D289	R:R:N285	39.2898	13.46	No	No	0	9	9
28	R:R:F245	R:R:N285	45.279	14.5	No	No	0	8	9
29	R:R:F241	R:R:F245	47.6289	16.08	Yes	No	0	9	8
30	R:R:F195	R:R:F241	98.344	5.36	No	Yes	0	9	9
31	R:R:F195	R:R:H249	100	30.55	No	Yes	0	9	8
32	R:R:H249	R:R:Y102	83.9404	6.53	Yes	Yes	1	8	8
33	L:L:?1	R:R:Y102	64.0517	5.91	Yes	Yes	1	0	8
34	R:R:H248	R:R:H249	16.0857	10.75	Yes	Yes	1	7	8
35	R:R:H248	R:R:H275	10.2471	5.97	Yes	Yes	1	7	5
36	R:R:F107	R:R:F55	12.4268	4.29	Yes	Yes	2	8	7
37	R:R:W83	R:R:Y76	23.0699	8.68	Yes	Yes	1	8	6
38	R:R:L89	R:R:W83	16.5145	4.56	Yes	Yes	1	5	8
39	R:R:L85	R:R:W83	14.1548	6.83	Yes	Yes	1	7	8
40	R:R:R172	R:R:V170	13.2777	5.23	Yes	No	0	4	3
41	R:R:F241	R:R:I202	52.4628	3.77	Yes	Yes	0	9	7
42	R:R:I202	R:R:N206	47.894	4.25	Yes	Yes	0	7	9
43	R:R:C205	R:R:N206	45.2266	1.57	Yes	Yes	0	7	9
44	R:R:C205	R:R:F116	37.9807	9.78	Yes	Yes	0	7	8
45	R:R:F116	R:R:I209	25.3805	2.51	Yes	No	0	8	8
46	L:L:?1	R:R:V184	16.3868	3.34	Yes	Yes	1	0	3
47	R:R:L260	R:R:V184	14.7963	2.98	Yes	Yes	1	1	3
48	R:R:F199	R:R:F241	10.4271	4.29	Yes	Yes	0	6	9
49	R:R:I209	R:R:L213	21.4597	2.85	No	Yes	0	8	8
50	L:L:?1	R:R:W255	11.4449	12.77	Yes	Yes	1	0	5
51	R:R:F66	R:R:S283	12.1879	3.96	Yes	No	0	7	7
52	L:L:?1	R:R:W73	25.8354	14.04	Yes	Yes	1	0	7
53	R:R:Y76	R:R:Y77	19.7382	7.94	Yes	Yes	1	6	6
54	R:R:C173	R:R:W73	14.973	6.53	Yes	Yes	1	9	7
55	R:R:C173	R:R:W83	10.6726	9.14	Yes	Yes	1	9	8
56	R:R:F97	R:R:F98	21.5218	4.29	Yes	No	1	7	5
57	R:R:F98	R:R:Y102	21.4204	5.16	No	Yes	1	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R14	R:R:Y77	5.14	1	Yes	Yes	4	6	2	1
R:R:Q276	R:R:R14	5.84	1	Yes	Yes	4	4	2	2
R:R:F18	R:R:Y77	17.54	0	Yes	Yes	5	6	2	1
R:R:F18	R:R:Q276	7.03	0	Yes	Yes	5	4	2	2
R:R:F66	R:R:F97	12.86	0	Yes	Yes	7	7	2	1
R:R:W73	R:R:Y76	4.82	1	Yes	Yes	7	6	1	2
R:R:W73	R:R:Y77	4.82	1	Yes	Yes	7	6	1	1
R:R:G94	R:R:W73	5.63	0	No	Yes	5	7	2	1
R:R:F97	R:R:W73	4.01	1	Yes	Yes	7	7	1	1
R:R:C173	R:R:W73	6.53	1	Yes	Yes	9	7	2	1
L:L:?1	R:R:W73	14.04	1	Yes	Yes	0	7	0	1
R:R:Y76	R:R:Y77	7.94	1	Yes	Yes	6	6	2	1
R:R:C173	R:R:Y76	4.03	1	Yes	Yes	9	6	2	2
L:L:?1	R:R:Y77	3.94	1	Yes	Yes	0	6	0	1
R:R:F174	R:R:G94	9.03	1	Yes	No	4	5	1	2
R:R:F97	R:R:F98	4.29	1	Yes	No	7	5	1	1
L:L:?1	R:R:F97	5.46	1	Yes	Yes	0	7	0	1
R:R:F98	R:R:Y102	5.16	1	No	Yes	5	8	1	1
L:L:?1	R:R:F98	21.84	1	Yes	No	0	5	0	1
R:R:T101	R:R:Y102	8.74	0	No	Yes	8	8	2	1
R:R:I191	R:R:Y102	15.71	1	No	Yes	6	8	1	1
R:R:H249	R:R:Y102	6.53	1	Yes	Yes	8	8	2	1
R:R:Q252	R:R:Y102	3.38	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y102	5.91	1	Yes	Yes	0	8	0	1
R:R:F152	R:R:Y151	6.19	1	No	No	5	7	1	2
R:R:F152	R:R:I187	12.56	1	No	No	5	5	1	1
L:L:?1	R:R:F152	4.78	1	Yes	No	0	5	0	1
R:R:F174	R:R:S157	6.61	1	Yes	No	4	5	1	2
R:R:S157	R:R:Y177	3.82	1	No	Yes	5	6	2	1
R:R:F174	R:R:Y177	7.22	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:F174	8.87	1	Yes	Yes	0	4	0	1
R:R:V184	R:R:Y177	5.05	1	Yes	Yes	3	6	1	1
L:L:?1	R:R:Y177	11.83	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V184	3.34	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:I187	10.4	1	Yes	No	0	5	0	1
R:R:H188	R:R:Q252	8.65	0	No	Yes	4	7	1	2
R:R:H188	R:R:T256	15.06	0	No	No	4	5	1	2
L:L:?1	R:R:H188	15.85	1	Yes	No	0	4	0	1
R:R:F190	R:R:I191	3.77	1	No	No	5	6	1	1
R:R:F190	R:R:S194	7.93	1	No	No	5	6	1	1
L:L:?1	R:R:F190	7.51	1	Yes	No	0	5	0	1
L:L:?1	R:R:I191	7.2	1	Yes	No	0	6	0	1
L:L:?1	R:R:S194	4.21	1	Yes	No	0	6	0	1
R:R:H248	R:R:H249	10.75	1	Yes	Yes	7	8	2	2
R:R:H248	R:R:Q252	18.54	1	Yes	Yes	7	7	2	2
R:R:H248	R:R:H275	5.97	1	Yes	Yes	7	5	2	1
R:R:H248	R:R:T278	6.85	1	Yes	Yes	7	7	2	2
R:R:H249	R:R:Q252	3.71	1	Yes	Yes	8	7	2	2
R:R:H275	R:R:V251	6.92	1	Yes	No	5	5	1	2
R:R:T278	R:R:V251	4.76	1	Yes	No	7	5	2	2
R:R:T256	R:R:W255	3.64	0	No	Yes	5	5	2	1
R:R:E259	R:R:W255	13.08	1	Yes	Yes	2	5	2	1
R:R:H275	R:R:W255	24.33	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:W255	12.77	1	Yes	Yes	0	5	0	1
R:R:H275	R:R:Q276	3.71	1	Yes	Yes	5	4	1	2
R:R:H275	R:R:T278	5.48	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:H275	4.32	1	Yes	Yes	0	5	0	1
R:R:S181	R:R:V184	3.23	0	No	Yes	4	3	2	1
R:R:L260	R:R:V184	2.98	1	Yes	Yes	1	3	2	1
R:R:C95	R:R:F174	2.79	0	No	Yes	6	4	2	1
R:R:P19	R:R:Y77	2.78	0	No	Yes	5	6	2	1
R:R:I271	R:R:W255	1.17	0	No	Yes	4	5	2	1
L:L:?1	R:R:A148	0.88	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XYD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.24
Number of Linked Nodes	286
Number of Links	342
Number of Hubs	53
Number of Links mediated by Hubs	193
Number of Communities	6
Number of Nodes involved in Communities	68
Number of Links involved in Communities	107

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	63881
Length Of Smallest Path	3
Average Path Length	13.4273
Length of Longest Path	35
Minimum Path Strength	1.44
Average Path Strength	7.24942
Maximum Path Strength	20.65
Minimum Path Correlation	0.7
Average Path Correlation	0.937365
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	57.7735
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.8177
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • binding • lipid binding • lipopolysaccharide binding • carbohydrate derivative binding • platelet activating factor receptor activity • phospholipid binding • pattern recognition receptor activity • lipopolysaccharide immune receptor activity • protein binding • kinase binding • enzyme binding • protein kinase binding • mitogen-activated protein kinase binding • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • positive regulation of biological process • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • cellular extravasation • cell migration • regulation of immune system process • cell motility • positive regulation of immune system process • locomotion • positive regulation of cellular process
Gene Ontology	Biological Process	• positive regulation of locomotion • regulation of cell motility • regulation of cellular process • positive regulation of biological process • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • cellular extravasation • cell migration • regulation of immune system process • cell motility • positive regulation of immune system process • locomotion • positive regulation of cellular process • regulation of biological process • regulation of leukocyte migration • biological regulation • positive regulation of leukocyte migration • leukocyte migration • immune system process • regulation of locomotion • cellular process • positive regulation of cellular extravasation • regulation of cellular extravasation • response to stimulus • immune response • interleukin-6 production • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of interleukin-6 production • regulation of interleukin-6 production • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • multi-multicellular organism process • reproductive process • parturition • multi-organism reproductive process • cellular response to nitrogen compound • cellular response to stimulus • response to organophosphorus • response to oxygen-containing compound • response to nitrogen compound • response to purine-containing compound • response to cAMP • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to cAMP • chemotaxis • taxis • response to external stimulus • positive regulation of protein metabolic process • positive regulation of translation • regulation of primary metabolic process • post-transcriptional regulation of gene expression • protein metabolic process • regulation of protein metabolic process • primary metabolic process • translation • regulation of translation • regulation of reproductive process • multicellular organismal reproductive process • positive regulation of maternal process involved in parturition • maternal process involved in parturition • regulation of maternal process involved in parturition • positive regulation of reproductive process • response to ketone • response to lipid • response to endogenous stimulus • response to glucocorticoid • response to corticosteroid • response to hormone • response to steroid hormone • response to dexamethasone • positive regulation of leukocyte cell-cell adhesion • regulation of leukocyte adhesion to vascular endothelial cell • leukocyte cell-cell adhesion • leukocyte tethering or rolling • positive regulation of cell-cell adhesion • cell adhesion • cell-cell adhesion • positive regulation of leukocyte tethering or rolling • regulation of cell-cell adhesion • positive regulation of cell adhesion • regulation of cell adhesion • positive regulation of leukocyte adhesion to vascular endothelial cell • regulation of leukocyte tethering or rolling • leukocyte adhesion to vascular endothelial cell • regulation of leukocyte cell-cell adhesion • regulation of localization • regulation of transcytosis • transport • regulation of transport • positive regulation of transcytosis • regulation of vesicle-mediated transport • establishment of localization • vesicle-mediated transport • localization • positive regulation of transport • transcytosis • response to symbiont • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to symbiotic bacterium • response to external biotic stimulus • response to biotic stimulus • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine • response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine • cellular response to ether • response to ether • cellular response to lipid • cell population proliferation • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • defense response • response to stress • inflammatory response • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • regulation of DNA-templated transcription • response to fatty acid • cellular response to fatty acid • regulation of tumor necrosis factor production • positive regulation of tumor necrosis factor superfamily cytokine production • tumor necrosis factor superfamily cytokine production • positive regulation of tumor necrosis factor production • tumor necrosis factor production • regulation of tumor necrosis factor superfamily cytokine production • polyol metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • alcohol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of immune effector process • neutrophil activation • regulation of myeloid leukocyte mediated immunity • positive regulation of leukocyte mediated immunity • regulated exocytosis • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte mediated immunity • myeloid leukocyte activation • neutrophil activation involved in immune response • positive regulation of leukocyte degranulation • positive regulation of regulated secretory pathway • positive regulation of immune response • establishment of localization in cell • leukocyte mediated immunity • immune effector process • regulation of secretion • regulation of leukocyte mediated immunity • exocytosis • regulation of response to stimulus • positive regulation of myeloid leukocyte mediated immunity • regulation of immune response • cellular localization • positive regulation of secretion by cell • positive regulation of exocytosis • leukocyte activation • regulation of regulated secretory pathway • positive regulation of response to stimulus • neutrophil mediated immunity • secretion by cell • regulation of secretion by cell • positive regulation of secretion • regulation of neutrophil degranulation • leukocyte activation involved in immune response • neutrophil degranulation • positive regulation of immune effector process • regulation of leukocyte degranulation • secretion • cell activation • export from cell • myeloid cell activation involved in immune response • regulation of exocytosis • positive regulation of neutrophil degranulation • granulocyte activation • regulation of inositol phosphate biosynthetic process • positive regulation of phosphate metabolic process • regulation of small molecule metabolic process • regulation of phosphate metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • system process • circulatory system process • regulation of blood pressure • regulation of biological quality • negative regulation of blood pressure • blood circulation • gastro-intestinal system smooth muscle contraction • positive regulation of smooth muscle contraction • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • positive regulation of gastro-intestinal system smooth muscle contraction • regulation of gastro-intestinal system smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • response to abiotic stimulus • cellular response to gravity • response to gravity • cellular response to abiotic stimulus • cellular response to environmental stimulus • membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • cell periphery • plasma membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PFS
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PFS
Name	Platelet Activating Factor
Synonyms	1-hexadecyl-2-acetyl-glycero-3-phosphocholine
Identifier
Formula	C26 H54 N O7 P
Molecular Weight	523.683
SMILES
PubChem	108156
Formal Charge	0
Total Atoms	89
Total Chiral Atoms	1
Total Bonds	88
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25105
Sequence	>8XYD_nogp_Chain_R S H M D S E F R Y T L F P I V Y S I I F V L G V I A N G Y V L W V F A R L Y P C K K F N E I K I F M V N L T M A D M L F L I T L P L W I V Y Y Q N Q G N W I L P K F L C N V A G C L F F I N T Y C S V A F L G V I T Y N R F Q A V T R P I K T A Q A N T R K R G I S L S L V I W V A I V G A A S Y F L I L D S T N T V P D S A G S G N V T R C F E H Y E K G S V P V L I I H I F I V F S F F L V F L I I L F C N L V I I R T L L M Q P V Q Q Q R N A E V K R R A L W M V C T V L A V F I I C F V P H H V V Q L P W T L A E L G F Q D S K F H Q A I N D A H Q V T L C L L S T N C V L D P V I Y C F L T K K F R K H L T E K F Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XYD	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	Platelet Activating Factor	-	Gi1/β1/γ2	2.9	2024-11-13	10.1016/j.celrep.2024.114422
	8XYD (No Gprot)	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	Platelet Activating Factor	-		2.9	2024-11-13	10.1016/j.celrep.2024.114422
	5ZKQ	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	ABT-491	-	-	2.9	2018-06-20	10.1038/s41594-018-0068-y
	5ZKP	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	Foropafant (SR27417)	-	-	2.81	2018-06-20	10.1038/s41594-018-0068-y

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