psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H176	R:R:S7	4.18	Yes	No	0	4	5
2	R:R:E259	R:R:S7	10.06	Yes	No	0	2	5
3	R:R:E259	R:R:M9	5.41	Yes	Yes	1	2	1
4	R:R:H268	R:R:M9	19.7	No	Yes	1	2	1
5	R:R:M9	R:R:Q269	8.16	Yes	No	0	1	2
6	R:R:D10	R:R:R14	10.72	Yes	Yes	1	6	4
7	R:R:D10	R:R:Y15	10.34	Yes	Yes	1	6	5
8	R:R:D10	R:R:R172	8.34	Yes	Yes	1	6	4
9	R:R:D10	R:R:H176	11.35	Yes	Yes	1	6	4
10	R:R:F13	R:R:S11	10.57	Yes	Yes	1	6	7
11	R:R:R14	R:R:S11	5.27	Yes	Yes	1	4	7
12	R:R:N272	R:R:S11	4.47	No	Yes	1	4	7
13	R:R:Q276	R:R:S11	4.33	Yes	Yes	1	4	7
14	R:R:F13	R:R:L17	3.65	Yes	No	0	6	5
15	R:R:D273	R:R:F13	9.55	No	Yes	0	1	6
16	R:R:F13	R:R:Q276	5.86	Yes	Yes	1	6	4
17	R:R:R14	R:R:Y15	16.46	Yes	Yes	1	4	5
18	R:R:R14	R:R:Y77	5.14	Yes	Yes	1	4	6
19	R:R:E175	R:R:R14	11.63	No	Yes	1	4	4
20	R:R:H176	R:R:R14	5.64	Yes	Yes	1	4	4
21	R:R:Q276	R:R:R14	5.84	Yes	Yes	1	4	4
22	R:R:Q80	R:R:Y15	6.76	No	Yes	0	3	5
23	R:R:G81	R:R:Y15	5.79	No	Yes	0	5	5
24	R:R:R172	R:R:Y15	5.14	Yes	Yes	1	4	5
25	R:R:F18	R:R:L17	4.87	Yes	No	0	5	5
26	R:R:F18	R:R:Y22	7.22	Yes	Yes	0	5	8
27	R:R:F18	R:R:Y77	17.54	Yes	Yes	0	5	6
28	R:R:F18	R:R:Q276	7.03	Yes	Yes	0	5	4
29	R:R:F18	R:R:L279	3.65	Yes	No	0	5	6
30	R:R:L70	R:R:Y22	8.21	No	Yes	0	8	8
31	R:R:I74	R:R:Y22	4.84	No	Yes	0	8	8
32	R:R:S283	R:R:Y22	7.63	No	Yes	0	7	8
33	R:R:I24	R:R:L28	4.28	No	No	0	4	6
34	R:R:F26	R:R:P71	7.22	No	No	0	7	8
35	R:R:G29	R:R:L67	5.13	No	No	0	8	6
36	R:R:N33	R:R:T60	5.85	No	No	0	9	9
37	R:R:D63	R:R:N33	4.04	No	No	0	9	9
38	R:R:M64	R:R:N33	7.01	No	No	0	7	9
39	R:R:H303	R:R:Y35	4.36	Yes	No	3	4	5
40	R:R:L304	R:R:Y35	3.52	No	No	0	6	5
41	R:R:K307	R:R:Y35	4.78	No	No	3	3	5
42	R:R:T60	R:R:V36	7.93	No	No	0	9	8
43	R:R:C294	R:R:V36	5.12	No	No	0	7	8
44	R:R:F295	R:R:V36	3.93	Yes	No	0	7	8
45	R:R:L37	R:R:T60	5.9	No	No	0	7	9
46	R:R:R42	R:R:W38	15.99	No	No	0	5	4
47	R:R:F300	R:R:V39	10.49	No	No	0	8	7
48	R:R:F40	R:R:Y44	7.22	No	Yes	0	7	5
49	R:R:F40	R:R:M56	6.22	No	No	0	7	8
50	R:R:L43	R:R:Y44	15.24	No	Yes	0	5	5
51	R:R:K299	R:R:L43	7.05	Yes	No	0	6	5
52	R:R:K48	R:R:Y44	3.58	No	Yes	4	6	5
53	R:R:K53	R:R:Y44	10.75	No	Yes	4	7	5
54	R:R:K48	R:R:P45	5.02	No	No	0	6	4
55	R:R:K48	R:R:K53	4.31	No	No	4	6	7
56	R:R:K53	R:R:N50	4.2	No	No	0	7	7
57	R:R:E51	R:R:F55	10.49	Yes	Yes	2	6	7
58	R:R:E51	R:R:N114	10.52	Yes	No	2	6	8
59	R:R:E51	R:R:T130	12.7	Yes	No	0	6	6
60	R:R:E51	R:R:R133	6.98	Yes	No	0	6	3
61	R:R:E51	R:R:G134	8.19	Yes	No	0	6	8
62	R:R:I135	R:R:I54	5.89	No	No	0	3	7
63	R:R:F107	R:R:F55	4.29	Yes	Yes	2	8	7
64	R:R:F55	R:R:V110	13.11	Yes	No	0	7	7
65	R:R:F55	R:R:I111	5.02	Yes	No	0	7	8
66	R:R:F55	R:R:N114	4.83	Yes	No	2	7	8
67	R:R:C294	R:R:M56	3.24	No	No	0	7	8
68	R:R:F107	R:R:N58	12.08	Yes	Yes	2	8	9
69	R:R:N58	R:R:S138	8.94	Yes	No	2	9	7
70	R:R:N58	R:R:W142	4.52	Yes	No	2	9	9
71	R:R:L59	R:R:S104	4.5	No	No	0	9	9
72	R:R:L108	R:R:L59	8.3	No	No	0	9	9
73	R:R:C286	R:R:D63	6.22	No	No	0	8	9
74	R:R:L65	R:R:N100	6.87	No	No	0	6	8
75	R:R:F66	R:R:L70	8.53	Yes	No	0	7	8
76	R:R:F66	R:R:F97	12.86	Yes	Yes	0	7	7
77	R:R:F66	R:R:N100	4.83	Yes	No	0	7	8
78	R:R:F66	R:R:S283	3.96	Yes	No	0	7	7
79	R:R:C286	R:R:F66	6.98	No	Yes	0	8	7
80	R:R:L96	R:R:T69	7.37	No	No	0	5	6
81	R:R:L72	R:R:L89	6.92	No	Yes	0	6	5
82	R:R:W73	R:R:Y76	4.82	Yes	Yes	1	7	6
83	R:R:W73	R:R:Y77	4.82	Yes	Yes	1	7	6
84	R:R:G94	R:R:W73	5.63	No	Yes	0	5	7
85	R:R:F97	R:R:W73	4.01	Yes	Yes	1	7	7
86	R:R:C173	R:R:W73	6.53	Yes	Yes	1	9	7
87	L:L:?1	R:R:W73	14.04	Yes	Yes	1	0	7
88	R:R:Y76	R:R:Y77	7.94	Yes	Yes	1	6	6
89	R:R:G81	R:R:Y76	10.14	No	Yes	0	5	6
90	R:R:W83	R:R:Y76	8.68	Yes	Yes	1	8	6
91	R:R:R172	R:R:Y76	4.12	Yes	Yes	1	4	6
92	R:R:C173	R:R:Y76	4.03	Yes	Yes	1	9	6
93	R:R:E175	R:R:Y76	11.22	No	Yes	1	4	6
94	L:L:?1	R:R:Y77	3.94	Yes	Yes	1	0	6
95	R:R:N79	R:R:Q78	6.6	No	No	0	4	4
96	R:R:N82	R:R:V170	4.43	No	No	0	5	3
97	R:R:L85	R:R:W83	6.83	Yes	Yes	1	7	8
98	R:R:L89	R:R:W83	4.56	Yes	Yes	1	5	8
99	R:R:C90	R:R:W83	9.14	No	Yes	1	9	8
100	R:R:C173	R:R:W83	9.14	Yes	Yes	1	9	8
101	R:R:L85	R:R:P86	4.93	Yes	No	0	7	8
102	R:R:L85	R:R:L89	4.15	Yes	Yes	1	7	5
103	R:R:D156	R:R:K87	4.15	No	No	1	5	3
104	R:R:K87	R:R:T158	9.01	No	No	1	3	5
105	R:R:F88	R:R:V92	5.24	No	No	0	2	5
106	R:R:C173	R:R:C90	7.28	Yes	No	1	9	9
107	R:R:N91	R:R:S157	5.96	No	No	0	7	5
108	R:R:F174	R:R:G94	9.03	Yes	No	0	4	5
109	R:R:C95	R:R:L153	4.76	No	No	0	6	5
110	R:R:F97	R:R:F98	4.29	Yes	No	1	7	5
111	L:L:?1	R:R:F97	5.46	Yes	Yes	1	0	7
112	R:R:F98	R:R:Y102	5.16	No	Yes	1	5	8
113	L:L:?1	R:R:F98	21.84	Yes	No	1	0	5
114	R:R:T101	R:R:Y102	8.74	No	Yes	0	8	8
115	R:R:I191	R:R:Y102	15.71	No	Yes	1	6	8
116	R:R:H249	R:R:Y102	6.53	Yes	Yes	1	8	8
117	R:R:Q252	R:R:Y102	3.38	Yes	Yes	1	7	8
118	L:L:?1	R:R:Y102	5.91	Yes	Yes	1	0	8
119	R:R:C103	R:R:F107	5.59	No	Yes	2	7	8
120	R:R:C103	R:R:W142	5.22	No	No	2	7	9
121	R:R:F245	R:R:V105	3.93	No	No	0	8	7
122	R:R:F107	R:R:S138	5.28	Yes	No	2	8	7
123	R:R:F107	R:R:W142	8.02	Yes	No	2	8	9
124	R:R:D289	R:R:L108	4.07	No	No	0	9	9
125	R:R:L108	R:R:Y293	8.21	No	Yes	0	9	9
126	R:R:G109	R:R:I202	3.53	No	Yes	0	8	7
127	R:R:I111	R:R:R115	3.76	No	No	0	8	9
128	R:R:I202	R:R:T112	10.64	Yes	No	0	7	9
129	R:R:Q117	R:R:Y113	18.04	No	No	0	6	6
130	R:R:R115	R:R:Y293	7.2	No	Yes	0	9	9
131	R:R:F116	R:R:T120	10.38	Yes	No	0	8	8
132	R:R:C205	R:R:F116	9.78	Yes	Yes	0	7	8
133	R:R:F116	R:R:V208	7.87	Yes	No	0	8	3
134	R:R:A118	R:R:T125	3.36	No	No	0	8	6
135	R:R:I209	R:R:V119	7.68	No	No	0	8	8
136	R:R:R121	R:R:T120	3.88	No	No	0	7	8
137	R:R:K124	R:R:R121	8.66	No	No	0	4	7
138	R:R:I123	R:R:K124	4.36	No	No	0	6	4
139	R:R:I123	R:R:Q127	4.12	No	No	0	6	4
140	R:R:L137	R:R:R133	3.64	No	No	0	5	3
141	R:R:G147	R:R:S150	3.71	No	No	0	3	4
142	R:R:F152	R:R:Y151	6.19	No	No	0	5	7
143	R:R:L155	R:R:Y151	3.52	No	No	0	5	7
144	R:R:P183	R:R:Y151	6.95	No	No	0	3	7
145	R:R:F152	R:R:I187	12.56	No	No	1	5	5
146	L:L:?1	R:R:F152	4.78	Yes	No	1	0	5
147	R:R:D156	R:R:T158	7.23	No	No	1	5	5
148	R:R:F174	R:R:S157	6.61	Yes	No	1	4	5
149	R:R:S157	R:R:Y177	3.82	No	Yes	1	5	6
150	R:R:P162	R:R:V161	3.53	No	No	0	2	1
151	R:R:R172	R:R:V161	5.23	Yes	No	0	4	1
152	R:R:R172	R:R:V170	5.23	Yes	No	0	4	3
153	R:R:H176	R:R:R172	10.16	Yes	Yes	1	4	4
154	R:R:F174	R:R:Y177	7.22	Yes	Yes	1	4	6
155	L:L:?1	R:R:F174	8.87	Yes	Yes	1	0	4
156	R:R:E175	R:R:H176	9.85	No	Yes	1	4	4
157	R:R:V184	R:R:Y177	5.05	Yes	Yes	1	3	6
158	L:L:?1	R:R:Y177	11.83	Yes	Yes	1	0	6
159	R:R:G180	R:R:L260	3.42	No	Yes	1	1	1
160	R:R:F262	R:R:G180	4.52	Yes	No	1	1	1
161	R:R:P183	R:R:V182	3.53	No	No	0	3	1
162	L:L:?1	R:R:V184	3.34	Yes	Yes	1	0	3
163	R:R:I189	R:R:L185	7.14	No	Yes	0	4	4
164	R:R:L185	R:R:L257	4.15	Yes	No	0	4	4
165	R:R:L185	R:R:L260	4.15	Yes	Yes	1	4	1
166	R:R:F262	R:R:L185	7.31	Yes	Yes	1	1	4
167	L:L:?1	R:R:I187	10.4	Yes	No	1	0	5
168	R:R:H188	R:R:Q252	8.65	No	Yes	0	4	7
169	R:R:H188	R:R:T256	15.06	No	No	0	4	5
170	L:L:?1	R:R:H188	15.85	Yes	No	0	0	4
171	R:R:F193	R:R:I189	6.28	No	No	0	4	4
172	R:R:F190	R:R:I191	3.77	No	No	1	5	6
173	R:R:F190	R:R:S194	7.93	No	No	1	5	6
174	L:L:?1	R:R:F190	7.51	Yes	No	1	0	5
175	L:L:?1	R:R:I191	7.2	Yes	No	1	0	6
176	L:L:?1	R:R:S194	4.21	Yes	No	1	0	6
177	R:R:F195	R:R:F196	5.36	No	No	0	9	5
178	R:R:F195	R:R:F241	5.36	No	Yes	0	9	9
179	R:R:F195	R:R:H249	30.55	No	Yes	0	9	8
180	R:R:F199	R:R:L203	4.87	Yes	No	0	6	4
181	R:R:F199	R:R:F241	4.29	Yes	Yes	0	6	9
182	R:R:F199	R:R:I242	5.02	Yes	No	6	6	5
183	R:R:F199	R:R:V246	3.93	Yes	Yes	6	6	6
184	R:R:I202	R:R:N206	4.25	Yes	Yes	0	7	9
185	R:R:F241	R:R:I202	3.77	Yes	Yes	0	9	7
186	R:R:L203	R:R:L207	8.3	No	No	0	4	3
187	R:R:F204	R:R:V208	7.87	No	No	0	5	3
188	R:R:N206	R:R:V234	5.91	Yes	No	0	9	8
189	R:R:L238	R:R:N206	13.73	No	Yes	0	8	9
190	R:R:I210	R:R:L231	4.28	No	Yes	0	5	5
191	R:R:L213	R:R:L231	4.15	Yes	Yes	0	8	5
192	R:R:L214	R:R:L231	9.69	No	Yes	0	4	5
193	R:R:K227	R:R:Q221	9.49	No	No	0	6	4
194	R:R:N223	R:R:V226	8.87	No	No	0	4	5
195	R:R:K227	R:R:N223	5.6	No	No	0	6	4
196	R:R:E225	R:R:R228	12.79	No	No	0	4	5
197	R:R:R229	R:R:R301	9.6	No	No	0	7	8
198	R:R:L231	R:R:W232	3.42	Yes	No	0	5	5
199	R:R:I292	R:R:V237	4.61	No	No	5	7	8
200	R:R:V237	R:R:Y293	6.31	No	Yes	5	8	9
201	R:R:I242	R:R:L238	7.14	No	No	0	5	8
202	R:R:I292	R:R:V240	4.61	No	No	0	7	6
203	R:R:F241	R:R:F245	16.08	Yes	No	0	9	8
204	R:R:I242	R:R:V246	4.61	No	Yes	6	5	6
205	R:R:C244	R:R:N285	9.45	No	No	0	8	9
206	R:R:F245	R:R:N285	14.5	No	No	0	8	9
207	R:R:P247	R:R:V246	3.53	No	Yes	0	9	6
208	R:R:H248	R:R:H249	10.75	Yes	Yes	1	7	8
209	R:R:H248	R:R:Q252	18.54	Yes	Yes	1	7	7
210	R:R:H248	R:R:H275	5.97	Yes	Yes	1	7	5
211	R:R:H248	R:R:T278	6.85	Yes	Yes	1	7	7
212	R:R:H248	R:R:L279	3.86	Yes	No	0	7	6
213	R:R:H248	R:R:L282	15.43	Yes	No	0	7	8
214	R:R:H249	R:R:Q252	3.71	Yes	Yes	1	8	7
215	R:R:A274	R:R:V251	3.39	No	No	0	5	5
216	R:R:H275	R:R:V251	6.92	Yes	No	1	5	5
217	R:R:T278	R:R:V251	4.76	Yes	No	1	7	5
218	R:R:L253	R:R:P254	4.93	No	No	0	6	5
219	R:R:L253	R:R:L257	5.54	No	No	0	6	4
220	R:R:T256	R:R:W255	3.64	No	Yes	0	5	5
221	R:R:E259	R:R:W255	13.08	Yes	Yes	1	2	5
222	R:R:H275	R:R:W255	24.33	Yes	Yes	1	5	5
223	L:L:?1	R:R:W255	12.77	Yes	Yes	1	0	5
224	R:R:L257	R:R:Q263	9.32	No	No	0	4	1
225	R:R:A258	R:R:H268	7.32	No	No	0	4	2
226	R:R:E259	R:R:H268	11.08	Yes	No	1	2	2
227	R:R:F262	R:R:L260	7.31	Yes	Yes	1	1	1
228	R:R:F262	R:R:Q263	4.68	Yes	No	0	1	1
229	R:R:F267	R:R:K266	17.37	No	No	0	1	1
230	R:R:D273	R:R:N272	4.04	No	No	0	1	4
231	R:R:N272	R:R:Q276	6.6	No	Yes	1	4	4
232	R:R:H275	R:R:Q276	3.71	Yes	Yes	1	5	4
233	R:R:H275	R:R:T278	5.48	Yes	Yes	1	5	7
234	L:L:?1	R:R:H275	4.32	Yes	Yes	1	0	5
235	R:R:D289	R:R:N285	13.46	No	No	0	9	9
236	R:R:F295	R:R:V291	7.87	Yes	No	0	7	6
237	R:R:I292	R:R:Y293	3.63	No	Yes	5	7	9
238	R:R:C294	R:R:F300	5.59	No	No	0	7	8
239	R:R:F295	R:R:F300	6.43	Yes	No	0	7	8
240	R:R:L296	R:R:R301	3.64	No	No	0	7	8
241	R:R:K298	R:R:T297	4.5	No	No	0	5	8
242	R:R:H303	R:R:K299	11.79	Yes	Yes	0	4	6
243	R:R:H303	R:R:K307	17.03	Yes	No	3	4	3
244	R:R:F308	R:R:L304	3.65	No	No	0	5	6
245	R:R:S181	R:R:V184	3.23	No	Yes	0	4	3
246	R:R:D63	R:R:P290	3.22	No	No	0	9	9
247	R:R:F49	R:R:R131	3.21	No	No	0	5	2
248	R:R:C280	R:R:L17	3.17	No	No	0	6	5
249	R:R:H303	R:R:W38	3.17	Yes	No	0	4	4
250	R:R:C286	R:R:L67	3.17	No	No	0	8	6
251	R:R:T212	R:R:V119	3.17	No	No	0	5	8
252	R:R:C235	R:R:L231	3.17	No	Yes	0	4	5
253	R:R:P217	R:R:Q221	3.16	No	No	0	4	4
254	R:R:A93	R:R:L72	3.15	No	No	0	5	6
255	R:R:I25	R:R:S283	3.1	No	No	0	7	7
256	R:R:I25	R:R:V21	3.07	No	No	0	7	6
257	R:R:I25	R:R:V287	3.07	No	No	0	7	8
258	R:R:I31	R:R:V27	3.07	No	No	0	5	5
259	R:R:I186	R:R:V182	3.07	No	No	0	4	1
260	R:R:I202	R:R:V198	3.07	Yes	No	0	7	9
261	R:R:M64	R:R:V30	3.04	No	No	0	7	5
262	R:R:A224	R:R:Q221	3.03	No	No	0	3	4
263	R:R:L28	R:R:V27	2.98	No	No	0	6	5
264	R:R:L28	R:R:V287	2.98	No	No	0	6	8
265	R:R:L89	R:R:V92	2.98	Yes	No	0	5	5
266	R:R:L96	R:R:V92	2.98	No	No	0	5	5
267	R:R:L260	R:R:V184	2.98	Yes	Yes	1	1	3
268	R:R:L253	R:R:V192	2.98	No	No	0	6	5
269	R:R:L288	R:R:V240	2.98	No	No	0	6	6
270	R:R:N159	R:R:V161	2.96	No	No	0	2	1
271	R:R:L281	R:R:T284	2.95	No	No	0	8	5
272	R:R:I145	R:R:I99	2.94	No	No	0	8	5
273	R:R:I141	R:R:I145	2.94	No	No	0	7	8
274	R:R:D163	R:R:S164	2.94	No	No	0	1	1
275	R:R:D163	R:R:V170	2.92	No	No	0	1	3
276	R:R:Q219	R:R:V218	2.87	No	No	0	3	3
277	R:R:I84	R:R:L85	2.85	No	Yes	0	2	7
278	R:R:I135	R:R:L139	2.85	No	No	0	3	3
279	R:R:I209	R:R:L213	2.85	No	Yes	0	8	8
280	R:R:I52	R:R:N114	2.83	No	No	0	7	8
281	R:R:I54	R:R:N58	2.83	No	Yes	0	7	9
282	R:R:I99	R:R:N100	2.83	No	No	0	5	8
283	R:R:K227	R:R:L213	2.82	No	Yes	0	6	8
284	R:R:C95	R:R:F174	2.79	No	Yes	0	6	4
285	R:R:P19	R:R:Y77	2.78	No	Yes	0	5	6
286	R:R:A32	R:R:F295	2.77	No	Yes	0	7	7
287	R:R:C205	R:R:Y113	2.69	Yes	No	0	7	6
288	R:R:E178	R:R:N159	2.63	No	No	0	3	2
289	R:R:F116	R:R:I209	2.51	Yes	No	0	8	8
290	R:R:F267	R:R:I271	2.51	No	No	0	1	4
291	R:R:F26	R:R:L67	2.44	No	No	0	7	6
292	R:R:N129	R:R:R131	2.41	No	No	0	6	2
293	R:R:F49	R:R:Y44	2.06	No	Yes	0	5	5
294	R:R:R228	R:R:W232	2	No	No	0	5	5
295	R:R:A165	R:R:G166	1.95	No	No	0	2	1
296	R:R:A165	R:R:G168	1.95	No	No	0	2	3
297	R:R:A62	R:R:C103	1.81	No	No	0	8	7
298	R:R:A149	R:R:C95	1.81	No	No	0	7	6
299	R:R:G34	R:R:M64	1.75	No	No	0	4	7
300	R:R:G180	R:R:K179	1.74	No	No	0	1	3
301	R:R:C90	R:R:T158	1.69	No	No	1	9	5
302	R:R:I123	R:R:P122	1.69	No	No	0	6	8
303	R:R:C244	R:R:T284	1.69	No	No	0	8	5
304	R:R:D163	R:R:G168	1.68	No	No	0	1	3
305	R:R:C205	R:R:I201	1.64	Yes	No	0	7	6
306	R:R:C46	R:R:K47	1.62	No	No	0	4	5
307	R:R:A106	R:R:I141	1.62	No	No	0	6	7
308	R:R:S136	R:R:V140	1.62	No	No	0	2	4
309	R:R:S150	R:R:V146	1.62	No	No	0	4	4
310	R:R:V246	R:R:V250	1.6	Yes	No	0	6	6
311	R:R:T236	R:R:V240	1.59	No	No	0	6	6
312	R:R:T278	R:R:V277	1.59	Yes	No	0	7	6
313	R:R:A230	R:R:L213	1.58	No	Yes	0	7	8
314	R:R:P217	R:R:Q216	1.58	No	No	0	4	5
315	R:R:T160	R:R:T171	1.57	No	No	0	4	5
316	R:R:C205	R:R:N206	1.57	Yes	Yes	0	7	9
317	R:R:I20	R:R:S23	1.55	No	No	0	5	5
318	R:R:I24	R:R:S23	1.55	No	No	0	4	5
319	R:R:I74	R:R:S23	1.55	No	No	0	8	5
320	R:R:K302	R:R:T305	1.5	No	No	0	3	4
321	R:R:L37	R:R:V57	1.49	No	No	0	7	5
322	R:R:N79	R:R:V75	1.48	No	No	0	4	4
323	R:R:N82	R:R:T171	1.46	No	No	0	5	5
324	R:R:N159	R:R:T160	1.46	No	No	0	2	4
325	R:R:Q263	R:R:S265	1.44	No	No	0	1	7
326	R:R:K298	R:R:K299	1.44	No	Yes	0	5	6
327	R:R:K299	R:R:K302	1.44	Yes	No	0	6	3
328	R:R:I243	R:R:L281	1.43	No	No	0	6	8
329	R:R:I84	R:R:N79	1.42	No	No	0	2	4
330	R:R:Q117	R:R:T125	1.42	No	No	0	6	6
331	R:R:K132	R:R:N129	1.4	No	No	0	4	6
332	R:R:A270	R:R:F267	1.39	No	No	0	3	1
333	R:R:H8	R:R:M9	1.31	No	Yes	0	6	1
334	R:R:R211	R:R:V208	1.31	No	No	0	4	3
335	R:R:F13	R:R:T16	1.3	Yes	No	0	6	5
336	R:R:F26	R:R:I68	1.26	No	No	0	7	5
337	R:R:M233	R:R:R229	1.24	No	No	0	8	7
338	R:R:E306	R:R:H303	1.23	No	Yes	0	4	4
339	R:R:F193	R:R:L197	1.22	No	No	0	4	6
340	R:R:F295	R:R:L296	1.22	Yes	No	0	7	7
341	R:R:I271	R:R:W255	1.17	No	Yes	0	4	5
342	L:L:?1	R:R:A148	0.88	Yes	No	0	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M9	8.645	4	1	1
2	R:R:D10	10.1875	4	1	6
3	R:R:S11	6.16	4	1	7
4	R:R:F13	6.186	5	1	6
5	R:R:R14	8.67143	7	1	4
6	R:R:Y15	8.898	5	1	5
7	R:R:F18	8.062	5	0	5
8	R:R:Y22	6.975	4	0	8
9	R:R:Y44	7.77	5	4	5
10	R:R:E51	9.776	5	2	6
11	R:R:F55	7.548	5	2	7
12	R:R:N58	7.0925	4	2	9
13	R:R:F66	7.432	5	0	7
14	R:R:W73	6.64167	6	1	7
15	R:R:Y76	7.27857	7	1	6
16	R:R:Y77	7.02667	6	1	6
17	R:R:W83	7.67	5	1	8
18	R:R:L85	4.69	4	1	7
19	R:R:L89	4.6525	4	1	5
20	R:R:F97	6.655	4	1	7
21	R:R:Y102	7.57167	6	1	8
22	R:R:F107	7.052	5	2	8
23	R:R:F116	7.635	4	0	8
24	R:R:R172	6.37	6	1	4
25	R:R:C173	6.745	4	1	9
26	R:R:F174	6.904	5	1	4
27	R:R:H176	8.236	5	1	4
28	R:R:Y177	6.98	4	1	6
29	R:R:V184	3.65	4	1	3
30	R:R:L185	5.6875	4	1	4
31	R:R:F199	4.5275	4	6	6
32	R:R:I202	5.052	5	0	7
33	R:R:C205	3.92	4	0	7
34	R:R:N206	6.365	4	0	9
35	R:R:L213	2.85	4	0	8
36	R:R:L231	4.942	5	0	5
37	R:R:F241	7.375	4	0	9
38	R:R:V246	3.4175	4	6	6
39	R:R:H248	10.2333	6	1	7
40	R:R:H249	12.885	4	1	8
41	R:R:Q252	8.57	4	1	7
42	R:R:W255	10.998	5	1	5
43	R:R:E259	9.9075	4	1	2
44	R:R:L260	4.465	4	1	1
45	R:R:F262	5.955	4	1	1
46	R:R:H275	8.455	6	1	5
47	R:R:Q276	5.56167	6	1	4
48	R:R:T278	4.67	4	1	7
49	R:R:Y293	6.3375	4	5	9
50	R:R:F295	4.444	5	0	7
51	R:R:K299	5.43	4	0	6
52	R:R:H303	7.516	5	3	4
53	L:L:?1	8.42059	17	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R172	R:R:Y76	20.9393	4.12	Yes	Yes	1	4	6
2	R:R:F18	R:R:Y22	15.2283	7.22	Yes	Yes	0	5	8
3	R:R:I25	R:R:S283	10.5547	3.1	No	No	0	7	7
4	R:R:C286	R:R:F66	66.3394	6.98	No	Yes	0	8	7
5	R:R:F66	R:R:F97	72.597	12.86	Yes	Yes	0	7	7
6	R:R:F97	R:R:W73	14.8028	4.01	Yes	Yes	1	7	7
7	R:R:W73	R:R:Y76	24.5721	4.82	Yes	Yes	1	7	6
8	L:L:?1	R:R:F97	37.4014	5.46	Yes	Yes	1	0	7
9	L:L:?1	R:R:Y77	22.124	3.94	Yes	Yes	1	0	6
10	R:R:C286	R:R:D63	59.6825	6.22	No	No	0	8	9
11	R:R:D63	R:R:N33	57.4112	4.04	No	No	0	9	9
12	R:R:N33	R:R:T60	52.7901	5.85	No	No	0	9	9
13	R:R:T60	R:R:V36	49.2554	7.93	No	No	0	9	8
14	R:R:C294	R:R:V36	37.061	5.12	No	No	0	7	8
15	R:R:C294	R:R:M56	33.9781	3.24	No	No	0	7	8
16	R:R:F40	R:R:M56	32.6722	6.22	No	No	0	7	8
17	R:R:F40	R:R:Y44	31.3828	7.22	No	Yes	0	7	5
18	R:R:L43	R:R:Y44	19.4731	15.24	No	Yes	0	5	5
19	R:R:K299	R:R:L43	18.0985	7.05	Yes	No	0	6	5
20	R:R:H303	R:R:K299	11.278	11.79	Yes	Yes	0	4	6
21	R:R:F295	R:R:V36	12.1584	3.93	Yes	No	0	7	8
22	R:R:F55	R:R:I111	24.3266	5.02	Yes	No	0	7	8
23	R:R:I111	R:R:R115	25.6161	3.76	No	No	0	8	9
24	R:R:R115	R:R:Y293	26.8205	7.2	No	Yes	0	9	9
25	R:R:L108	R:R:Y293	34.3806	8.21	No	Yes	0	9	9
26	R:R:D289	R:R:L108	38.0723	4.07	No	No	0	9	9
27	R:R:D289	R:R:N285	39.2898	13.46	No	No	0	9	9
28	R:R:F245	R:R:N285	45.279	14.5	No	No	0	8	9
29	R:R:F241	R:R:F245	47.6289	16.08	Yes	No	0	9	8
30	R:R:F195	R:R:F241	98.344	5.36	No	Yes	0	9	9
31	R:R:F195	R:R:H249	100	30.55	No	Yes	0	9	8
32	R:R:H249	R:R:Y102	83.9404	6.53	Yes	Yes	1	8	8
33	L:L:?1	R:R:Y102	64.0517	5.91	Yes	Yes	1	0	8
34	R:R:H248	R:R:H249	16.0857	10.75	Yes	Yes	1	7	8
35	R:R:H248	R:R:H275	10.2471	5.97	Yes	Yes	1	7	5
36	R:R:F107	R:R:F55	12.4268	4.29	Yes	Yes	2	8	7
37	R:R:W83	R:R:Y76	23.0699	8.68	Yes	Yes	1	8	6
38	R:R:L89	R:R:W83	16.5145	4.56	Yes	Yes	1	5	8
39	R:R:L85	R:R:W83	14.1548	6.83	Yes	Yes	1	7	8
40	R:R:R172	R:R:V170	13.2777	5.23	Yes	No	0	4	3
41	R:R:F241	R:R:I202	52.4628	3.77	Yes	Yes	0	9	7
42	R:R:I202	R:R:N206	47.894	4.25	Yes	Yes	0	7	9
43	R:R:C205	R:R:N206	45.2266	1.57	Yes	Yes	0	7	9
44	R:R:C205	R:R:F116	37.9807	9.78	Yes	Yes	0	7	8
45	R:R:F116	R:R:I209	25.3805	2.51	Yes	No	0	8	8
46	L:L:?1	R:R:V184	16.3868	3.34	Yes	Yes	1	0	3
47	R:R:L260	R:R:V184	14.7963	2.98	Yes	Yes	1	1	3
48	R:R:F199	R:R:F241	10.4271	4.29	Yes	Yes	0	6	9
49	R:R:I209	R:R:L213	21.4597	2.85	No	Yes	0	8	8
50	L:L:?1	R:R:W255	11.4449	12.77	Yes	Yes	1	0	5
51	R:R:F66	R:R:S283	12.1879	3.96	Yes	No	0	7	7
52	L:L:?1	R:R:W73	25.8354	14.04	Yes	Yes	1	0	7
53	R:R:Y76	R:R:Y77	19.7382	7.94	Yes	Yes	1	6	6
54	R:R:C173	R:R:W73	14.973	6.53	Yes	Yes	1	9	7
55	R:R:C173	R:R:W83	10.6726	9.14	Yes	Yes	1	9	8
56	R:R:F97	R:R:F98	21.5218	4.29	Yes	No	1	7	5
57	R:R:F98	R:R:Y102	21.4204	5.16	No	Yes	1	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R14	R:R:Y77	5.14	1	Yes	Yes	4	6	2	1
R:R:Q276	R:R:R14	5.84	1	Yes	Yes	4	4	2	2
R:R:F18	R:R:Y77	17.54	0	Yes	Yes	5	6	2	1
R:R:F18	R:R:Q276	7.03	0	Yes	Yes	5	4	2	2
R:R:F66	R:R:F97	12.86	0	Yes	Yes	7	7	2	1
R:R:W73	R:R:Y76	4.82	1	Yes	Yes	7	6	1	2
R:R:W73	R:R:Y77	4.82	1	Yes	Yes	7	6	1	1
R:R:G94	R:R:W73	5.63	0	No	Yes	5	7	2	1
R:R:F97	R:R:W73	4.01	1	Yes	Yes	7	7	1	1
R:R:C173	R:R:W73	6.53	1	Yes	Yes	9	7	2	1
L:L:?1	R:R:W73	14.04	1	Yes	Yes	0	7	0	1
R:R:Y76	R:R:Y77	7.94	1	Yes	Yes	6	6	2	1
R:R:C173	R:R:Y76	4.03	1	Yes	Yes	9	6	2	2
L:L:?1	R:R:Y77	3.94	1	Yes	Yes	0	6	0	1
R:R:F174	R:R:G94	9.03	1	Yes	No	4	5	1	2
R:R:F97	R:R:F98	4.29	1	Yes	No	7	5	1	1
L:L:?1	R:R:F97	5.46	1	Yes	Yes	0	7	0	1
R:R:F98	R:R:Y102	5.16	1	No	Yes	5	8	1	1
L:L:?1	R:R:F98	21.84	1	Yes	No	0	5	0	1
R:R:T101	R:R:Y102	8.74	0	No	Yes	8	8	2	1
R:R:I191	R:R:Y102	15.71	1	No	Yes	6	8	1	1
R:R:H249	R:R:Y102	6.53	1	Yes	Yes	8	8	2	1
R:R:Q252	R:R:Y102	3.38	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y102	5.91	1	Yes	Yes	0	8	0	1
R:R:F152	R:R:Y151	6.19	1	No	No	5	7	1	2
R:R:F152	R:R:I187	12.56	1	No	No	5	5	1	1
L:L:?1	R:R:F152	4.78	1	Yes	No	0	5	0	1
R:R:F174	R:R:S157	6.61	1	Yes	No	4	5	1	2
R:R:S157	R:R:Y177	3.82	1	No	Yes	5	6	2	1
R:R:F174	R:R:Y177	7.22	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:F174	8.87	1	Yes	Yes	0	4	0	1
R:R:V184	R:R:Y177	5.05	1	Yes	Yes	3	6	1	1
L:L:?1	R:R:Y177	11.83	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V184	3.34	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:I187	10.4	1	Yes	No	0	5	0	1
R:R:H188	R:R:Q252	8.65	0	No	Yes	4	7	1	2
R:R:H188	R:R:T256	15.06	0	No	No	4	5	1	2
L:L:?1	R:R:H188	15.85	1	Yes	No	0	4	0	1
R:R:F190	R:R:I191	3.77	1	No	No	5	6	1	1
R:R:F190	R:R:S194	7.93	1	No	No	5	6	1	1
L:L:?1	R:R:F190	7.51	1	Yes	No	0	5	0	1
L:L:?1	R:R:I191	7.2	1	Yes	No	0	6	0	1
L:L:?1	R:R:S194	4.21	1	Yes	No	0	6	0	1
R:R:H248	R:R:H249	10.75	1	Yes	Yes	7	8	2	2
R:R:H248	R:R:Q252	18.54	1	Yes	Yes	7	7	2	2
R:R:H248	R:R:H275	5.97	1	Yes	Yes	7	5	2	1
R:R:H248	R:R:T278	6.85	1	Yes	Yes	7	7	2	2
R:R:H249	R:R:Q252	3.71	1	Yes	Yes	8	7	2	2
R:R:H275	R:R:V251	6.92	1	Yes	No	5	5	1	2
R:R:T278	R:R:V251	4.76	1	Yes	No	7	5	2	2
R:R:T256	R:R:W255	3.64	0	No	Yes	5	5	2	1
R:R:E259	R:R:W255	13.08	1	Yes	Yes	2	5	2	1
R:R:H275	R:R:W255	24.33	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:W255	12.77	1	Yes	Yes	0	5	0	1
R:R:H275	R:R:Q276	3.71	1	Yes	Yes	5	4	1	2
R:R:H275	R:R:T278	5.48	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:H275	4.32	1	Yes	Yes	0	5	0	1
R:R:S181	R:R:V184	3.23	0	No	Yes	4	3	2	1
R:R:L260	R:R:V184	2.98	1	Yes	Yes	1	3	2	1
R:R:C95	R:R:F174	2.79	0	No	Yes	6	4	2	1
R:R:P19	R:R:Y77	2.78	0	No	Yes	5	6	2	1
R:R:I271	R:R:W255	1.17	0	No	Yes	4	5	2	1
L:L:?1	R:R:A148	0.88	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XYD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.24
Number of Linked Nodes	286
Number of Links	342
Number of Hubs	53
Number of Links mediated by Hubs	193
Number of Communities	6
Number of Nodes involved in Communities	68
Number of Links involved in Communities	107

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	63881
Length Of Smallest Path	3
Average Path Length	13.4273
Length of Longest Path	35
Minimum Path Strength	1.44
Average Path Strength	7.24942
Maximum Path Strength	20.65
Minimum Path Correlation	0.7
Average Path Correlation	0.937383
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	57.7458
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.8177
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • pattern recognition receptor activity • lipopolysaccharide immune receptor activity • binding • lipid binding • lipopolysaccharide binding • carbohydrate derivative binding • platelet activating factor receptor activity • phospholipid binding • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • immune response • immune system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • immune response • immune system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • defense response • response to stress • inflammatory response • polyol metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • alcohol biosynthetic process • inositol trisphosphate metabolic process • metabolic process • small molecule metabolic process • phosphorus metabolic process • membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • cell periphery • plasma membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PFS
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PFS
Name	Platelet Activating Factor
Synonyms	Platelet-activating factor
Identifier
Formula	C26 H54 N O7 P
Molecular Weight	523.683
SMILES
PubChem	108156
Formal Charge	0
Total Atoms	89
Total Chiral Atoms	1
Total Bonds	88
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25105
Sequence	>8XYD_nogp_Chain_R S H M D S E F R Y T L F P I V Y S I I F V L G V I A N G Y V L W V F A R L Y P C K K F N E I K I F M V N L T M A D M L F L I T L P L W I V Y Y Q N Q G N W I L P K F L C N V A G C L F F I N T Y C S V A F L G V I T Y N R F Q A V T R P I K T A Q A N T R K R G I S L S L V I W V A I V G A A S Y F L I L D S T N T V P D S A G S G N V T R C F E H Y E K G S V P V L I I H I F I V F S F F L V F L I I L F C N L V I I R T L L M Q P V Q Q Q R N A E V K R R A L W M V C T V L A V F I I C F V P H H V V Q L P W T L A E L G F Q D S K F H Q A I N D A H Q V T L C L L S T N C V L D P V I Y C F L T K K F R K H L T E K F Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XYD	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	Platelet Activating Factor	-	Gi1/β1/γ2	2.9	2024-11-13	doi.org/10.1016/j.celrep.2024.114422
	8XYD (No Gprot)	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	Platelet Activating Factor	-		2.9	2024-11-13	doi.org/10.1016/j.celrep.2024.114422
	5ZKP	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	Foropafant (SR27417)	-	-	2.81	2018-06-20	doi.org/10.1038/s41594-018-0068-y
	5ZKQ	A	Lipid	Platelet Activating Factor	PAF	Homo sapiens	ABT-491	-	-	2.9	2018-06-20	doi.org/10.1038/s41594-018-0068-y

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XYD_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.