psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D127	24.81	Yes	Yes	1	0	6
2	L:L:?1	R:R:V128	4.81	Yes	No	0	0	4
3	L:L:?1	R:R:C131	5.12	Yes	No	1	0	7
4	L:L:?1	R:R:Y132	5.04	Yes	Yes	1	0	5
5	L:L:?1	R:R:N217	8.86	Yes	Yes	1	0	6
6	L:L:?1	R:R:W286	4.9	Yes	Yes	1	0	8
7	L:L:?1	R:R:Y289	15.12	Yes	Yes	1	0	6
8	L:L:?1	R:R:V312	11.21	Yes	No	1	0	5
9	L:L:?1	R:R:V315	8.01	Yes	Yes	1	0	7
10	L:L:?1	R:R:Y316	12.6	Yes	Yes	1	0	7
11	R:R:L50	R:R:Y51	7.03	No	No	3	6	5
12	R:R:L50	R:R:V109	5.96	No	No	3	6	5
13	R:R:V109	R:R:Y51	16.4	No	No	3	5	5
14	R:R:F54	R:R:G55	4.52	Yes	No	0	7	3
15	R:R:A58	R:R:F54	4.16	No	Yes	0	5	7
16	R:R:F54	R:R:M101	12.44	Yes	Yes	0	7	7
17	R:R:F54	R:R:M105	8.71	Yes	No	0	7	7
18	R:R:F54	R:R:W313	30.07	Yes	No	0	7	5
19	R:R:F54	R:R:Y317	12.38	Yes	No	0	7	6
20	R:R:F56	R:R:L60	4.87	No	No	0	4	5
21	R:R:F94	R:R:V62	6.55	Yes	No	0	7	6
22	R:R:M69	R:R:N65	4.21	No	Yes	2	7	9
23	R:R:A90	R:R:N65	4.69	No	Yes	0	9	9
24	R:R:D93	R:R:N65	12.12	No	Yes	2	9	9
25	R:R:F94	R:R:N65	12.08	Yes	Yes	2	7	9
26	R:R:N65	R:R:P323	6.52	Yes	No	2	9	9
27	R:R:F94	R:R:L66	4.87	Yes	No	0	7	4
28	R:R:F328	R:R:L67	3.65	No	No	0	6	7
29	R:R:F333	R:R:V68	5.24	Yes	No	0	8	9
30	R:R:F94	R:R:M69	3.73	Yes	No	2	7	7
31	R:R:F75	R:R:S71	5.28	No	Yes	0	5	8
32	R:R:A87	R:R:I72	6.5	No	Yes	0	5	7
33	R:R:F75	R:R:Q77	8.2	No	No	0	5	6
34	R:R:H79	R:R:R76	4.51	No	No	0	7	6
35	R:R:P81	R:R:S80	3.56	No	No	0	6	7
36	R:R:N83	R:R:S80	7.45	No	No	0	8	7
37	R:R:A161	R:R:P81	3.74	No	No	0	1	6
38	R:R:A82	R:R:D144	4.63	No	Yes	0	8	8
39	R:R:N83	R:R:W332	6.78	No	Yes	0	8	6
40	R:R:F84	R:R:S164	5.28	No	No	0	4	7
41	R:R:I141	R:R:L85	4.28	Yes	No	0	9	7
42	R:R:D144	R:R:L85	4.07	Yes	No	0	8	7
43	R:R:L85	R:R:S164	4.5	No	No	0	7	7
44	R:R:H137	R:R:S88	5.58	Yes	No	0	7	9
45	R:R:I168	R:R:S88	10.84	No	No	0	7	9
46	R:R:H137	R:R:L89	5.14	Yes	Yes	1	7	9
47	R:R:L138	R:R:L89	5.54	No	Yes	1	8	9
48	R:R:L89	R:R:N322	9.61	Yes	No	1	9	9
49	R:R:D93	R:R:P323	9.66	No	No	2	9	9
50	R:R:L95	R:R:V98	4.47	No	No	0	7	4
51	R:R:F130	R:R:L95	6.09	Yes	No	0	7	7
52	R:R:F130	R:R:V96	5.24	Yes	No	0	7	7
53	R:R:S319	R:R:V96	4.85	No	No	0	9	7
54	R:R:G97	R:R:M101	6.99	No	Yes	0	6	7
55	R:R:M99	R:R:V98	7.61	No	No	0	4	4
56	R:R:F126	R:R:M99	3.73	No	No	0	5	4
57	R:R:F130	R:R:M99	3.73	Yes	No	0	7	4
58	R:R:H123	R:R:V100	5.54	Yes	No	0	5	7
59	R:R:D127	R:R:V100	4.38	Yes	No	1	6	7
60	R:R:V100	R:R:Y316	5.05	No	Yes	1	7	7
61	R:R:M101	R:R:Y316	3.59	Yes	Yes	0	7	7
62	R:R:F103	R:R:Y119	5.16	No	No	0	5	6
63	R:R:F103	R:R:H123	4.53	No	Yes	0	5	5
64	R:R:H123	R:R:S104	5.58	Yes	No	0	5	6
65	R:R:E110	R:R:V106	8.56	No	No	0	4	4
66	R:R:R107	R:R:W113	12	No	Yes	0	4	8
67	R:R:E309	R:R:S108	7.19	No	No	0	5	5
68	R:R:S108	R:R:W313	8.65	No	No	0	5	5
69	R:R:F115	R:R:W113	17.04	No	Yes	0	6	8
70	R:R:C120	R:R:W113	6.53	No	Yes	0	9	8
71	R:R:H123	R:R:W113	7.41	Yes	Yes	0	5	8
72	R:R:F115	R:R:Y119	5.16	No	No	0	6	6
73	R:R:C120	R:R:C205	7.28	No	No	0	9	9
74	R:R:K121	R:R:Y184	7.17	No	No	0	6	4
75	R:R:F126	R:R:L122	6.09	No	No	0	5	5
76	R:R:I183	R:R:T124	6.08	No	No	0	5	4
77	R:R:I207	R:R:T124	4.56	No	No	0	4	4
78	R:R:C131	R:R:D127	4.67	No	Yes	1	7	6
79	R:R:D127	R:R:Y316	9.2	Yes	Yes	1	6	7
80	R:R:I183	R:R:V128	4.61	No	No	0	5	4
81	R:R:F130	R:R:S129	6.61	Yes	No	0	7	5
82	R:R:F136	R:R:Y132	4.13	No	Yes	0	5	5
83	R:R:N217	R:R:Y132	6.98	Yes	Yes	1	6	5
84	R:R:V220	R:R:Y132	5.05	No	Yes	0	5	5
85	R:R:W286	R:R:Y132	6.75	Yes	Yes	1	8	5
86	R:R:F290	R:R:Y132	4.13	Yes	Yes	1	7	5
87	R:R:C133	R:R:H137	7.37	No	Yes	1	7	7
88	R:R:C133	R:R:W172	11.75	No	Yes	1	7	9
89	R:R:C133	R:R:S175	5.16	No	No	0	7	8
90	R:R:F221	R:R:L135	6.09	No	No	0	8	7
91	R:R:L135	R:R:P224	4.93	No	No	0	7	9
92	R:R:F136	R:R:L174	6.09	No	Yes	0	5	3
93	R:R:H137	R:R:S171	8.37	Yes	No	0	7	6
94	R:R:H137	R:R:W172	8.46	Yes	Yes	1	7	9
95	R:R:L138	R:R:N322	5.49	No	No	1	8	9
96	R:R:L138	R:R:Y326	7.03	No	Yes	1	8	9
97	R:R:C139	R:R:P224	3.77	No	No	0	7	9
98	R:R:C167	R:R:F140	12.57	No	No	0	5	7
99	R:R:I141	R:R:R145	6.26	Yes	Yes	1	9	9
100	R:R:I141	R:R:Y326	3.63	Yes	Yes	1	9	9
101	R:R:M228	R:R:S142	6.13	No	No	1	8	9
102	R:R:S142	R:R:V231	4.85	No	Yes	1	9	7
103	R:R:S142	R:R:Y232	12.72	No	Yes	1	9	9
104	R:R:D144	R:R:Y155	5.75	Yes	Yes	4	8	7
105	R:R:D144	R:R:F159	11.94	Yes	No	4	8	7
106	R:R:R145	R:R:Y232	4.12	Yes	Yes	1	9	9
107	R:R:R145	R:R:Y326	6.17	Yes	Yes	1	9	9
108	R:R:R145	R:R:Y330	9.26	Yes	Yes	0	9	8
109	R:R:S150	R:R:Y146	5.09	No	Yes	0	6	8
110	R:R:V231	R:R:Y146	8.83	Yes	Yes	1	7	8
111	R:R:K234	R:R:Y146	13.14	No	Yes	1	5	8
112	R:R:I147	R:R:Y155	3.63	No	Yes	0	5	7
113	R:R:A148	R:R:Y155	6.67	No	Yes	0	8	7
114	R:R:I238	R:R:V149	4.61	No	No	0	5	8
115	R:R:A154	R:R:D151	4.63	No	Yes	0	4	5
116	R:R:D151	R:R:R158	3.57	Yes	No	0	5	4
117	R:R:P156	R:R:Y155	4.17	No	Yes	0	4	7
118	R:R:F159	R:R:Y155	4.13	No	Yes	4	7	7
119	R:R:S162	R:R:T160	4.8	No	No	0	4	8
120	R:R:T160	R:R:V163	4.76	No	No	0	8	6
121	R:R:L182	R:R:Y178	4.69	No	Yes	0	5	5
122	R:R:N217	R:R:Y178	4.65	Yes	Yes	0	6	5
123	R:R:V220	R:R:Y178	7.57	No	Yes	0	5	5
124	R:R:F180	R:R:Y184	9.28	No	No	0	4	4
125	R:R:L182	R:R:W213	6.83	No	No	0	5	7
126	R:R:Q206	R:R:Y308	13.53	No	No	0	3	3
127	R:R:I207	R:R:W213	11.74	No	No	0	4	7
128	R:R:N210	R:R:T212	7.31	No	No	0	5	3
129	R:R:F298	R:R:Q211	11.71	No	No	0	4	3
130	R:R:N217	R:R:W213	12.43	Yes	No	0	6	7
131	R:R:S293	R:R:V214	6.46	No	No	0	5	5
132	R:R:F294	R:R:V214	3.93	No	No	0	5	5
133	R:R:F290	R:R:N217	4.83	Yes	Yes	1	7	6
134	R:R:F218	R:R:L222	7.31	No	No	0	5	5
135	R:R:F218	R:R:F290	10.72	No	Yes	0	5	7
136	R:R:F218	R:R:F294	10.72	No	No	0	5	5
137	R:R:F221	R:R:W286	14.03	No	Yes	1	8	8
138	R:R:F221	R:R:F290	18.22	No	Yes	1	8	7
139	R:R:I223	R:R:P224	10.16	No	No	0	6	9
140	R:R:M228	R:R:Y232	4.79	No	Yes	1	8	9
141	R:R:F282	R:R:M228	12.44	No	No	0	9	8
142	R:R:K234	R:R:V231	4.55	No	Yes	1	5	7
143	R:R:L275	R:R:Y232	4.69	No	Yes	0	7	9
144	R:R:E268	R:R:F236	3.5	Yes	Yes	0	6	6
145	R:R:E268	R:R:K240	10.8	Yes	No	0	6	5
146	R:R:A243	R:R:R267	5.53	No	No	0	4	5
147	R:R:I246	R:R:R267	11.27	No	No	0	5	5
148	R:R:E247	R:R:R263	8.14	No	No	0	4	3
149	R:R:K248	R:R:K261	7.18	No	No	0	5	3
150	R:R:D262	R:R:R263	17.87	No	No	0	2	3
151	R:R:F329	R:R:T274	7.78	No	No	0	6	8
152	R:R:F329	R:R:I277	6.28	No	No	0	6	7
153	R:R:F282	R:R:V279	7.87	No	No	0	9	8
154	R:R:S285	R:R:W286	6.18	No	Yes	1	8	8
155	R:R:N318	R:R:S285	5.96	No	No	1	9	8
156	R:R:F290	R:R:W286	5.01	Yes	Yes	1	7	8
157	R:R:V315	R:R:W286	7.36	Yes	Yes	1	7	8
158	R:R:N318	R:R:W286	6.78	No	Yes	1	9	8
159	R:R:Y289	R:R:Y308	7.94	Yes	No	0	6	3
160	R:R:L311	R:R:Y289	3.52	No	Yes	0	5	6
161	R:R:V315	R:R:Y289	3.79	Yes	Yes	1	7	6
162	R:R:D292	R:R:T303	8.67	No	No	0	4	4
163	R:R:D292	R:R:L311	8.14	No	No	0	4	5
164	R:R:F294	R:R:F298	4.29	No	No	0	5	4
165	R:R:D296	R:R:I302	7	No	No	0	3	2
166	R:R:D296	R:R:T303	8.67	No	No	0	3	4
167	R:R:P304	R:R:T303	3.5	No	No	0	5	4
168	R:R:P304	R:R:Y306	9.74	No	No	5	5	1
169	R:R:P304	R:R:V307	7.07	No	No	5	5	4
170	R:R:V307	R:R:Y306	6.31	No	No	5	4	1
171	R:R:V312	R:R:Y308	5.05	No	No	0	5	3
172	R:R:V312	R:R:Y316	3.79	No	Yes	1	5	7
173	R:R:N318	R:R:N322	9.54	No	No	1	9	9
174	R:R:I325	R:R:Y326	4.84	No	Yes	0	8	9
175	R:R:A327	R:R:F333	8.32	No	Yes	0	7	8
176	R:R:W332	R:R:Y330	14.47	Yes	Yes	0	6	8
177	R:R:F333	R:R:W332	5.01	Yes	Yes	0	8	6
178	R:R:G64	R:R:L67	3.42	No	No	0	8	7
179	R:R:C139	R:R:V227	3.42	No	No	0	7	7
180	R:R:F75	R:R:H74	3.39	No	No	0	5	5
181	R:R:M101	R:R:P102	3.35	Yes	No	0	7	8
182	R:R:L287	R:R:P288	3.28	No	No	0	7	9
183	R:R:A281	R:R:I325	3.25	No	No	0	6	8
184	R:R:A61	R:R:M101	3.22	No	Yes	0	7	7
185	R:R:A281	R:R:M321	3.22	No	No	0	6	6
186	R:R:F328	R:R:F333	3.22	No	Yes	0	6	8
187	R:R:A336	R:R:L78	3.15	No	No	0	7	8
188	R:R:A280	R:R:L284	3.15	No	No	0	5	5
189	R:R:I337	R:R:S71	3.1	No	Yes	0	7	8
190	R:R:I176	R:R:S129	3.1	No	No	0	3	5
191	R:R:F329	R:R:Y330	3.09	No	Yes	0	6	8
192	R:R:I72	R:R:V86	3.07	Yes	No	0	7	8
193	R:R:I235	R:R:V149	3.07	No	No	0	8	8
194	R:R:I229	R:R:T225	3.04	No	No	0	5	5
195	R:R:K261	R:R:V264	3.04	No	Yes	0	3	3
196	R:R:A243	R:R:E268	3.02	No	Yes	0	4	6
197	R:R:L89	R:R:S134	3	Yes	No	0	9	9
198	R:R:G111	R:R:R107	3	No	No	0	4	4
199	R:R:L283	R:R:V279	2.98	No	No	0	5	8
200	R:R:G179	R:R:Y178	2.9	No	Yes	0	7	5
201	R:R:I72	R:R:L73	2.85	Yes	No	0	7	3
202	R:R:E268	R:R:V264	2.85	Yes	Yes	0	6	3
203	R:R:I291	R:R:L287	2.85	No	No	0	6	7
204	R:R:E309	R:R:T305	2.82	No	No	0	5	3
205	R:R:G116	R:R:W113	2.81	No	Yes	0	7	8
206	R:R:D292	R:R:I295	2.8	No	No	0	4	4
207	R:R:L324	R:R:L60	2.77	No	No	0	6	5
208	R:R:L222	R:R:L226	2.77	No	No	0	5	4
209	R:R:A271	R:R:F236	2.77	No	Yes	0	7	6
210	R:R:A272	R:R:F236	2.77	No	Yes	0	7	6
211	R:R:A297	R:R:F298	2.77	No	No	0	4	4
212	R:R:C125	R:R:Y184	2.69	No	No	0	5	4
213	R:R:F140	R:R:S171	2.64	No	No	0	7	6
214	R:R:C91	R:R:W172	2.61	No	Yes	0	7	9
215	R:R:A92	R:R:W172	2.59	No	Yes	0	8	9
216	R:R:F282	R:R:T225	2.59	No	No	0	9	5
217	R:R:V53	R:R:Y317	2.52	No	No	0	5	6
218	R:R:V96	R:R:Y316	2.52	No	Yes	0	7	7
219	R:R:F180	R:R:I176	2.51	No	No	0	4	3
220	R:R:K270	R:R:R267	2.48	No	No	0	8	5
221	R:R:F170	R:R:L174	2.44	No	Yes	0	4	3
222	R:R:F236	R:R:L237	2.44	Yes	No	0	6	3
223	R:R:I235	R:R:Y146	2.42	No	Yes	0	8	8
224	R:R:I216	R:R:Y178	2.42	No	Yes	0	4	5
225	R:R:I310	R:R:Y306	2.42	No	No	0	4	1
226	R:R:E110	R:R:R107	2.33	No	No	0	4	4
227	R:R:L78	R:R:W332	2.28	No	Yes	0	8	6
228	R:R:F84	R:R:H79	2.26	No	No	0	4	7
229	R:R:G203	R:R:G204	2.11	No	No	0	4	3
230	R:R:G165	R:R:S164	1.86	No	No	0	2	7
231	R:R:A320	R:R:A61	1.79	No	No	0	7	7
232	R:R:A239	R:R:A271	1.79	No	No	0	8	7
233	R:R:C63	R:R:V59	1.71	No	No	0	5	5
234	R:R:C139	R:R:V143	1.71	No	No	0	7	7
235	R:R:C167	R:R:V163	1.71	No	No	0	5	6
236	R:R:G276	R:R:L275	1.71	No	No	0	5	7
237	R:R:A90	R:R:V68	1.7	No	No	0	9	9
238	R:R:A297	R:R:V209	1.7	No	No	0	4	3
239	R:R:A154	R:R:T157	1.68	No	No	0	4	4
240	R:R:K335	R:R:P331	1.67	No	No	0	5	5
241	R:R:L311	R:R:P288	1.64	No	No	0	5	9
242	R:R:L324	R:R:P323	1.64	No	No	0	6	9
243	R:R:D151	R:R:P152	1.61	Yes	No	0	5	8
244	R:R:S71	R:R:T70	1.6	Yes	No	0	8	5
245	R:R:S233	R:R:T230	1.6	No	No	0	4	3
246	R:R:T230	R:R:V231	1.59	No	Yes	0	3	7
247	R:R:I72	R:R:V68	1.54	Yes	No	0	7	9
248	R:R:I141	R:R:V86	1.54	Yes	No	0	9	8
249	R:R:I314	R:R:V315	1.54	No	Yes	0	7	7
250	R:R:F54	R:R:G57	1.51	Yes	No	0	7	6
251	R:R:F56	R:R:G57	1.51	No	No	0	4	6
252	R:R:L67	R:R:S71	1.5	No	Yes	0	7	8
253	R:R:L122	R:R:S118	1.5	No	No	0	5	3
254	R:R:L174	R:R:S177	1.5	Yes	No	0	3	3
255	R:R:L60	R:R:V59	1.49	No	No	0	5	5
256	R:R:D117	R:R:S118	1.47	No	No	0	3	3
257	R:R:D151	R:R:S150	1.47	Yes	No	0	5	6
258	R:R:K266	R:R:K270	1.44	No	No	0	4	8
259	R:R:E110	R:R:V109	1.43	No	No	0	4	5
260	R:R:Q244	R:R:V264	1.43	No	Yes	0	4	3
261	R:R:E247	R:R:V264	1.43	No	Yes	0	4	3
262	R:R:G204	R:R:W113	1.41	No	Yes	0	3	8
263	R:R:P331	R:R:Y330	1.39	No	Yes	0	5	8
264	R:R:L173	R:R:L174	1.38	No	Yes	0	4	3
265	R:R:N245	R:R:Q241	1.32	No	No	0	3	4
266	R:R:N245	R:R:Q242	1.32	No	No	0	3	6
267	R:R:N245	R:R:Q244	1.32	No	No	0	3	4
268	R:R:K273	R:R:R269	1.24	No	No	0	7	5
269	R:R:F301	R:R:L299	1.22	No	No	0	2	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.048	10	1	0
2	R:R:F54	10.5414	7	0	7
3	R:R:N65	7.924	5	2	9
4	R:R:S71	2.87	4	0	8
5	R:R:I72	3.49	4	0	7
6	R:R:L89	5.8225	4	1	9
7	R:R:F94	6.8075	4	2	7
8	R:R:M101	5.918	5	0	7
9	R:R:W113	7.86667	6	0	8
10	R:R:H123	5.765	4	0	5
11	R:R:D127	10.765	4	1	6
12	R:R:F130	5.4175	4	0	7
13	R:R:Y132	5.34667	6	1	5
14	R:R:H137	6.984	5	1	7
15	R:R:I141	3.9275	4	1	9
16	R:R:D144	6.5975	4	4	8
17	R:R:R145	6.4525	4	1	9
18	R:R:Y146	7.37	4	1	8
19	R:R:D151	2.82	4	0	5
20	R:R:Y155	4.87	5	4	7
21	R:R:W172	6.3525	4	1	9
22	R:R:L174	2.8525	4	0	3
23	R:R:Y178	4.446	5	0	5
24	R:R:N217	7.55	5	1	6
25	R:R:V231	4.955	4	1	7
26	R:R:Y232	6.58	4	1	9
27	R:R:F236	2.87	4	0	6
28	R:R:V264	2.1875	4	0	3
29	R:R:E268	5.0425	4	0	6
30	R:R:W286	7.28714	7	1	8
31	R:R:Y289	7.5925	4	1	6
32	R:R:F290	8.582	5	1	7
33	R:R:V315	5.175	4	1	7
34	R:R:Y316	6.125	6	1	7
35	R:R:Y326	5.4175	4	1	9
36	R:R:Y330	7.0525	4	0	8
37	R:R:W332	7.135	4	0	6
38	R:R:F333	5.4475	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	63.2627	12.6	Yes	Yes	1	0	7
2	R:R:V100	R:R:Y316	27.1852	5.05	No	Yes	1	7	7
3	R:R:H123	R:R:V100	46.065	5.54	Yes	No	0	5	7
4	R:R:H123	R:R:W113	36.0446	7.41	Yes	Yes	0	5	8
5	R:R:R107	R:R:W113	18.273	12	No	Yes	0	4	8
6	R:R:E110	R:R:R107	13.0484	2.33	No	No	0	4	4
7	L:L:?1	R:R:D127	21.9474	24.81	Yes	Yes	1	0	6
8	R:R:D127	R:R:V100	21.1887	4.38	Yes	No	1	6	7
9	R:R:M101	R:R:Y316	30.6682	3.59	Yes	Yes	0	7	7
10	R:R:F54	R:R:M101	25.5228	12.44	Yes	Yes	0	7	7
11	R:R:F54	R:R:G57	15.2912	1.51	Yes	No	0	7	6
12	R:R:F56	R:R:G57	14.3611	1.51	No	No	0	4	6
13	R:R:F56	R:R:L60	14.0313	4.87	No	No	0	4	5
14	R:R:L324	R:R:L60	13.0615	2.77	No	No	0	6	5
15	R:R:L324	R:R:P323	12.9362	1.64	No	No	0	6	9
16	R:R:N65	R:R:P323	11.8741	6.52	Yes	No	2	9	9
17	L:L:?1	R:R:W286	75.2688	4.9	Yes	Yes	1	0	8
18	R:R:N318	R:R:W286	99.8681	6.78	No	Yes	1	9	8
19	R:R:N318	R:R:N322	100	9.54	No	No	1	9	9
20	R:R:L138	R:R:N322	80.909	5.49	No	No	1	8	9
21	R:R:L138	R:R:Y326	88.8053	7.03	No	Yes	1	8	9
22	R:R:I141	R:R:Y326	26.2616	3.63	Yes	Yes	1	9	9
23	R:R:I141	R:R:V86	14.5194	1.54	Yes	No	0	9	8
24	R:R:I72	R:R:V86	13.2133	3.07	Yes	No	0	7	8
25	R:R:A90	R:R:V68	13.2397	1.7	No	No	0	9	9
26	R:R:A90	R:R:N65	12.5206	4.69	No	Yes	0	9	9
27	R:R:R145	R:R:Y326	59.6411	6.17	Yes	Yes	1	9	9
28	R:R:R145	R:R:Y330	36.7307	9.26	Yes	Yes	0	9	8
29	R:R:W332	R:R:Y330	29.2368	14.47	Yes	Yes	0	6	8
30	R:R:F333	R:R:W332	20.9315	5.01	Yes	Yes	0	8	6
31	R:R:F328	R:R:F333	16.5578	3.22	No	Yes	0	6	8
32	R:R:F328	R:R:L67	14.7701	3.65	No	No	0	6	7
33	R:R:L67	R:R:S71	11.1551	1.5	No	Yes	0	7	8
34	R:R:I141	R:R:L85	23.1875	4.28	Yes	No	0	9	7
35	R:R:D144	R:R:L85	12.6525	4.07	Yes	No	0	8	7
36	R:R:L89	R:R:N322	18.5698	9.61	Yes	No	1	9	9
37	R:R:H137	R:R:L89	24.0055	5.14	Yes	Yes	1	7	9
38	R:R:V96	R:R:Y316	24.9951	2.52	No	Yes	0	7	7
39	R:R:F130	R:R:V96	22.2376	5.24	Yes	No	0	7	7
40	L:L:?1	R:R:Y132	12.8043	5.04	Yes	Yes	1	0	5
41	R:R:F290	R:R:W286	21.07	5.01	Yes	Yes	1	7	8
42	R:R:F221	R:R:W286	10.7527	14.03	No	Yes	1	8	8
43	R:R:F221	R:R:L135	10.3239	6.09	No	No	0	8	7
44	R:R:H137	R:R:S171	10.601	8.37	Yes	No	0	7	6
45	R:R:R145	R:R:Y232	41.5595	4.12	Yes	Yes	1	9	9
46	R:R:M228	R:R:Y232	10.5614	4.79	No	Yes	1	8	9
47	R:R:S142	R:R:Y232	26.4134	12.72	No	Yes	1	9	9
48	R:R:S142	R:R:V231	25.2985	4.85	No	Yes	1	9	7
49	R:R:V231	R:R:Y146	18.2664	8.83	Yes	Yes	1	7	8
50	R:R:S150	R:R:Y146	11.1551	5.09	No	Yes	0	6	8
51	L:L:?1	R:R:N217	18.0091	8.86	Yes	Yes	1	0	6
52	R:R:N217	R:R:Y178	10.878	4.65	Yes	Yes	0	6	5
53	R:R:F218	R:R:F290	30.6682	10.72	No	Yes	0	5	7
54	R:R:F218	R:R:F294	21.6043	10.72	No	No	0	5	5
55	R:R:F294	R:R:F298	12.4217	4.29	No	No	0	5	4
56	R:R:F290	R:R:N217	13.5431	4.83	Yes	Yes	1	7	6
57	L:L:?1	R:R:Y289	23.9726	15.12	Yes	Yes	1	0	6
58	R:R:L311	R:R:Y289	30.7804	3.52	No	Yes	0	5	6
59	R:R:D292	R:R:L311	21.545	8.14	No	No	0	4	5
60	R:R:D292	R:R:T303	16.8481	8.67	No	No	0	4	4
61	R:R:V315	R:R:W286	13.266	7.36	Yes	Yes	1	7	8
62	R:R:W286	R:R:Y132	12.0061	6.75	Yes	Yes	1	8	5
63	R:R:V315	R:R:Y289	11.9071	3.79	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D127	24.81	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V128	4.81	1	Yes	No	0	4	0	1
L:L:?1	R:R:C131	5.12	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y132	5.04	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N217	8.86	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W286	4.9	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y289	15.12	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V312	11.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:V315	8.01	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y316	12.6	1	Yes	Yes	0	7	0	1
R:R:D127	R:R:V100	4.38	1	Yes	No	6	7	1	2
R:R:V100	R:R:Y316	5.05	1	No	Yes	7	7	2	1
R:R:M101	R:R:Y316	3.59	0	Yes	Yes	7	7	2	1
R:R:C131	R:R:D127	4.67	1	No	Yes	7	6	1	1
R:R:D127	R:R:Y316	9.2	1	Yes	Yes	6	7	1	1
R:R:I183	R:R:V128	4.61	0	No	No	5	4	2	1
R:R:F136	R:R:Y132	4.13	0	No	Yes	5	5	2	1
R:R:N217	R:R:Y132	6.98	1	Yes	Yes	6	5	1	1
R:R:V220	R:R:Y132	5.05	0	No	Yes	5	5	2	1
R:R:W286	R:R:Y132	6.75	1	Yes	Yes	8	5	1	1
R:R:F290	R:R:Y132	4.13	1	Yes	Yes	7	5	2	1
R:R:N217	R:R:Y178	4.65	1	Yes	Yes	6	5	1	2
R:R:V220	R:R:Y178	7.57	0	No	Yes	5	5	2	2
R:R:N217	R:R:W213	12.43	1	Yes	No	6	7	1	2
R:R:F290	R:R:N217	4.83	1	Yes	Yes	7	6	2	1
R:R:F221	R:R:W286	14.03	1	No	Yes	8	8	2	1
R:R:F221	R:R:F290	18.22	1	No	Yes	8	7	2	2
R:R:S285	R:R:W286	6.18	1	No	Yes	8	8	2	1
R:R:N318	R:R:S285	5.96	1	No	No	9	8	2	2
R:R:F290	R:R:W286	5.01	1	Yes	Yes	7	8	2	1
R:R:V315	R:R:W286	7.36	1	Yes	Yes	7	8	1	1
R:R:N318	R:R:W286	6.78	1	No	Yes	9	8	2	1
R:R:Y289	R:R:Y308	7.94	1	Yes	No	6	3	1	2
R:R:L311	R:R:Y289	3.52	0	No	Yes	5	6	2	1
R:R:V315	R:R:Y289	3.79	1	Yes	Yes	7	6	1	1
R:R:V312	R:R:Y308	5.05	1	No	No	5	3	1	2
R:R:V312	R:R:Y316	3.79	1	No	Yes	5	7	1	1
R:R:V96	R:R:Y316	2.52	0	No	Yes	7	7	2	1
R:R:I314	R:R:V315	1.54	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8PM2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	245
Number of Links	269
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	5
Number of Nodes involved in Communities	44
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	32961
Length Of Smallest Path	3
Average Path Length	11.4514
Length of Longest Path	23
Minimum Path Strength	1.32
Average Path Strength	6.57725
Maximum Path Strength	21.255
Minimum Path Correlation	0.7
Average Path Correlation	0.91795
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	47.2817
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5547
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8IA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8IA
Name	~{N},~{N}-dimethylcyclohexanamine
Synonyms
Identifier
Formula	C8 H17 N
Molecular Weight	127.227
SMILES
PubChem	7415
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD08
Sequence	>8PM2_nogp_Chain_R I L Y A V F G F G A V L A V C G N L L V M T S I L H F R Q L H S P A N F L V A S L A C A D F L V G V M V M P F S M V R S V E G C W Y F G D S Y C K L H T C F D V S F C Y C S L F H L C F I S V D R Y I A V S D P L A Y P T R F T A S V S G K C I T F S W L L S I S Y G F S L I Y G G C Q I A V N Q T W V F I N F S V F L I P T L V M I T V Y S K I F L I A K Q Q A Q N I E K M S K D R V A K R E R K A A K T L G I A V A A F L L S W L P Y F I D S F I D A F L G F I T P T Y V Y E I L V W I V Y Y N S A M N P L I Y A F F Y P W F R K A I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8PM2	A	Amine	Trace Amine	TA7	Mus musculus	DMCHA	-	Gs/β1/γ2	2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	8PM2 (No Gprot)	A	Amine	Trace Amine	TA7	Mus musculus	DMCHA	-		2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.