psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D127	24.81	Yes	Yes	1	0	6
2	L:L:?1	R:R:V128	4.81	Yes	No	0	0	4
3	L:L:?1	R:R:C131	5.12	Yes	No	1	0	7
4	L:L:?1	R:R:Y132	5.04	Yes	Yes	1	0	5
5	L:L:?1	R:R:N217	8.86	Yes	Yes	1	0	6
6	L:L:?1	R:R:W286	4.9	Yes	Yes	1	0	8
7	L:L:?1	R:R:Y289	15.12	Yes	Yes	1	0	6
8	L:L:?1	R:R:V312	11.21	Yes	No	1	0	5
9	L:L:?1	R:R:V315	8.01	Yes	Yes	1	0	7
10	L:L:?1	R:R:Y316	12.6	Yes	Yes	1	0	7
11	R:R:L50	R:R:Y51	7.03	No	No	3	6	5
12	R:R:L50	R:R:V109	5.96	No	No	3	6	5
13	R:R:V109	R:R:Y51	16.4	No	No	3	5	5
14	R:R:F54	R:R:G55	4.52	Yes	No	0	7	3
15	R:R:A58	R:R:F54	4.16	No	Yes	0	5	7
16	R:R:F54	R:R:M101	12.44	Yes	Yes	0	7	7
17	R:R:F54	R:R:M105	8.71	Yes	No	0	7	7
18	R:R:F54	R:R:W313	30.07	Yes	No	0	7	5
19	R:R:F54	R:R:Y317	12.38	Yes	No	0	7	6
20	R:R:F56	R:R:L60	4.87	No	No	0	4	5
21	R:R:F94	R:R:V62	6.55	Yes	No	0	7	6
22	R:R:M69	R:R:N65	4.21	No	Yes	2	7	9
23	R:R:A90	R:R:N65	4.69	No	Yes	0	9	9
24	R:R:D93	R:R:N65	12.12	No	Yes	2	9	9
25	R:R:F94	R:R:N65	12.08	Yes	Yes	2	7	9
26	R:R:N65	R:R:P323	6.52	Yes	No	2	9	9
27	R:R:F94	R:R:L66	4.87	Yes	No	0	7	4
28	R:R:F328	R:R:L67	3.65	No	No	0	6	7
29	R:R:F333	R:R:V68	5.24	Yes	No	0	8	9
30	R:R:F94	R:R:M69	3.73	Yes	No	2	7	7
31	R:R:F75	R:R:S71	5.28	No	Yes	0	5	8
32	R:R:A87	R:R:I72	6.5	No	Yes	0	5	7
33	R:R:F75	R:R:Q77	8.2	No	No	0	5	6
34	R:R:H79	R:R:R76	4.51	No	No	0	7	6
35	R:R:P81	R:R:S80	3.56	No	No	0	6	7
36	R:R:N83	R:R:S80	7.45	No	No	0	8	7
37	R:R:A161	R:R:P81	3.74	No	No	0	1	6
38	R:R:A82	R:R:D144	4.63	No	Yes	0	8	8
39	R:R:N83	R:R:W332	6.78	No	Yes	0	8	6
40	R:R:F84	R:R:S164	5.28	No	No	0	4	7
41	R:R:I141	R:R:L85	4.28	Yes	No	0	9	7
42	R:R:D144	R:R:L85	4.07	Yes	No	0	8	7
43	R:R:L85	R:R:S164	4.5	No	No	0	7	7
44	R:R:H137	R:R:S88	5.58	Yes	No	0	7	9
45	R:R:I168	R:R:S88	10.84	No	No	0	7	9
46	R:R:H137	R:R:L89	5.14	Yes	Yes	1	7	9
47	R:R:L138	R:R:L89	5.54	No	Yes	1	8	9
48	R:R:L89	R:R:N322	9.61	Yes	No	1	9	9
49	R:R:D93	R:R:P323	9.66	No	No	2	9	9
50	R:R:L95	R:R:V98	4.47	No	No	0	7	4
51	R:R:F130	R:R:L95	6.09	Yes	No	0	7	7
52	R:R:F130	R:R:V96	5.24	Yes	No	0	7	7
53	R:R:S319	R:R:V96	4.85	No	No	0	9	7
54	R:R:G97	R:R:M101	6.99	No	Yes	0	6	7
55	R:R:M99	R:R:V98	7.61	No	No	0	4	4
56	R:R:F126	R:R:M99	3.73	No	No	0	5	4
57	R:R:F130	R:R:M99	3.73	Yes	No	0	7	4
58	R:R:H123	R:R:V100	5.54	Yes	No	0	5	7
59	R:R:D127	R:R:V100	4.38	Yes	No	1	6	7
60	R:R:V100	R:R:Y316	5.05	No	Yes	1	7	7
61	R:R:M101	R:R:Y316	3.59	Yes	Yes	0	7	7
62	R:R:F103	R:R:Y119	5.16	No	No	0	5	6
63	R:R:F103	R:R:H123	4.53	No	Yes	0	5	5
64	R:R:H123	R:R:S104	5.58	Yes	No	0	5	6
65	R:R:E110	R:R:V106	8.56	No	No	0	4	4
66	R:R:R107	R:R:W113	12	No	Yes	0	4	8
67	R:R:E309	R:R:S108	7.19	No	No	0	5	5
68	R:R:S108	R:R:W313	8.65	No	No	0	5	5
69	R:R:F115	R:R:W113	17.04	No	Yes	0	6	8
70	R:R:C120	R:R:W113	6.53	No	Yes	0	9	8
71	R:R:H123	R:R:W113	7.41	Yes	Yes	0	5	8
72	R:R:F115	R:R:Y119	5.16	No	No	0	6	6
73	R:R:C120	R:R:C205	7.28	No	No	0	9	9
74	R:R:K121	R:R:Y184	7.17	No	No	0	6	4
75	R:R:F126	R:R:L122	6.09	No	No	0	5	5
76	R:R:I183	R:R:T124	6.08	No	No	0	5	4
77	R:R:I207	R:R:T124	4.56	No	No	0	4	4
78	R:R:C131	R:R:D127	4.67	No	Yes	1	7	6
79	R:R:D127	R:R:Y316	9.2	Yes	Yes	1	6	7
80	R:R:I183	R:R:V128	4.61	No	No	0	5	4
81	R:R:F130	R:R:S129	6.61	Yes	No	0	7	5
82	R:R:F136	R:R:Y132	4.13	No	Yes	0	5	5
83	R:R:N217	R:R:Y132	6.98	Yes	Yes	1	6	5
84	R:R:V220	R:R:Y132	5.05	No	Yes	0	5	5
85	R:R:W286	R:R:Y132	6.75	Yes	Yes	1	8	5
86	R:R:F290	R:R:Y132	4.13	Yes	Yes	1	7	5
87	R:R:C133	R:R:H137	7.37	No	Yes	1	7	7
88	R:R:C133	R:R:W172	11.75	No	Yes	1	7	9
89	R:R:C133	R:R:S175	5.16	No	No	0	7	8
90	R:R:F221	R:R:L135	6.09	No	No	0	8	7
91	R:R:L135	R:R:P224	4.93	No	No	0	7	9
92	R:R:F136	R:R:L174	6.09	No	Yes	0	5	3
93	R:R:H137	R:R:S171	8.37	Yes	No	0	7	6
94	R:R:H137	R:R:W172	8.46	Yes	Yes	1	7	9
95	R:R:L138	R:R:N322	5.49	No	No	1	8	9
96	R:R:L138	R:R:Y326	7.03	No	Yes	1	8	9
97	R:R:C139	R:R:P224	3.77	No	No	0	7	9
98	R:R:C167	R:R:F140	12.57	No	No	0	5	7
99	R:R:I141	R:R:R145	6.26	Yes	Yes	1	9	9
100	R:R:I141	R:R:Y326	3.63	Yes	Yes	1	9	9
101	R:R:M228	R:R:S142	6.13	No	No	1	8	9
102	R:R:S142	R:R:V231	4.85	No	Yes	1	9	7
103	R:R:S142	R:R:Y232	12.72	No	Yes	1	9	9
104	R:R:D144	R:R:Y155	5.75	Yes	Yes	4	8	7
105	R:R:D144	R:R:F159	11.94	Yes	No	4	8	7
106	R:R:R145	R:R:Y232	4.12	Yes	Yes	1	9	9
107	R:R:R145	R:R:Y326	6.17	Yes	Yes	1	9	9
108	R:R:R145	R:R:Y330	9.26	Yes	Yes	0	9	8
109	R:R:S150	R:R:Y146	5.09	No	Yes	0	6	8
110	R:R:V231	R:R:Y146	8.83	Yes	Yes	1	7	8
111	R:R:K234	R:R:Y146	13.14	No	Yes	1	5	8
112	R:R:I147	R:R:Y155	3.63	No	Yes	0	5	7
113	R:R:A148	R:R:Y155	6.67	No	Yes	0	8	7
114	R:R:I238	R:R:V149	4.61	No	No	0	5	8
115	R:R:A154	R:R:D151	4.63	No	Yes	0	4	5
116	R:R:D151	R:R:R158	3.57	Yes	No	0	5	4
117	R:R:P156	R:R:Y155	4.17	No	Yes	0	4	7
118	R:R:F159	R:R:Y155	4.13	No	Yes	4	7	7
119	R:R:S162	R:R:T160	4.8	No	No	0	4	8
120	R:R:T160	R:R:V163	4.76	No	No	0	8	6
121	R:R:L182	R:R:Y178	4.69	No	Yes	0	5	5
122	R:R:N217	R:R:Y178	4.65	Yes	Yes	0	6	5
123	R:R:V220	R:R:Y178	7.57	No	Yes	0	5	5
124	R:R:F180	R:R:Y184	9.28	No	No	0	4	4
125	R:R:L182	R:R:W213	6.83	No	No	0	5	7
126	R:R:Q206	R:R:Y308	13.53	No	No	0	3	3
127	R:R:I207	R:R:W213	11.74	No	No	0	4	7
128	R:R:N210	R:R:T212	7.31	No	No	0	5	3
129	R:R:F298	R:R:Q211	11.71	No	No	0	4	3
130	R:R:N217	R:R:W213	12.43	Yes	No	0	6	7
131	R:R:S293	R:R:V214	6.46	No	No	0	5	5
132	R:R:F294	R:R:V214	3.93	No	No	0	5	5
133	R:R:F290	R:R:N217	4.83	Yes	Yes	1	7	6
134	R:R:F218	R:R:L222	7.31	No	No	0	5	5
135	R:R:F218	R:R:F290	10.72	No	Yes	0	5	7
136	R:R:F218	R:R:F294	10.72	No	No	0	5	5
137	R:R:F221	R:R:W286	14.03	No	Yes	1	8	8
138	R:R:F221	R:R:F290	18.22	No	Yes	1	8	7
139	R:R:I223	R:R:P224	10.16	No	No	0	6	9
140	R:R:M228	R:R:Y232	4.79	No	Yes	1	8	9
141	R:R:F282	R:R:M228	12.44	No	No	0	9	8
142	R:R:K234	R:R:V231	4.55	No	Yes	1	5	7
143	R:R:L275	R:R:Y232	4.69	No	Yes	0	7	9
144	R:R:E268	R:R:F236	3.5	Yes	Yes	0	6	6
145	R:R:E268	R:R:K240	10.8	Yes	No	0	6	5
146	R:R:A243	R:R:R267	5.53	No	No	0	4	5
147	R:R:I246	R:R:R267	11.27	No	No	0	5	5
148	R:R:E247	R:R:R263	8.14	No	No	0	4	3
149	R:R:K248	R:R:K261	7.18	No	No	0	5	3
150	R:R:D262	R:R:R263	17.87	No	No	0	2	3
151	R:R:F329	R:R:T274	7.78	No	No	0	6	8
152	R:R:F329	R:R:I277	6.28	No	No	0	6	7
153	R:R:F282	R:R:V279	7.87	No	No	0	9	8
154	R:R:S285	R:R:W286	6.18	No	Yes	1	8	8
155	R:R:N318	R:R:S285	5.96	No	No	1	9	8
156	R:R:F290	R:R:W286	5.01	Yes	Yes	1	7	8
157	R:R:V315	R:R:W286	7.36	Yes	Yes	1	7	8
158	R:R:N318	R:R:W286	6.78	No	Yes	1	9	8
159	R:R:Y289	R:R:Y308	7.94	Yes	No	0	6	3
160	R:R:L311	R:R:Y289	3.52	No	Yes	0	5	6
161	R:R:V315	R:R:Y289	3.79	Yes	Yes	1	7	6
162	R:R:D292	R:R:T303	8.67	No	No	0	4	4
163	R:R:D292	R:R:L311	8.14	No	No	0	4	5
164	R:R:F294	R:R:F298	4.29	No	No	0	5	4
165	R:R:D296	R:R:I302	7	No	No	0	3	2
166	R:R:D296	R:R:T303	8.67	No	No	0	3	4
167	R:R:P304	R:R:T303	3.5	No	No	0	5	4
168	R:R:P304	R:R:Y306	9.74	No	No	5	5	1
169	R:R:P304	R:R:V307	7.07	No	No	5	5	4
170	R:R:V307	R:R:Y306	6.31	No	No	5	4	1
171	R:R:V312	R:R:Y308	5.05	No	No	0	5	3
172	R:R:V312	R:R:Y316	3.79	No	Yes	1	5	7
173	R:R:N318	R:R:N322	9.54	No	No	1	9	9
174	R:R:I325	R:R:Y326	4.84	No	Yes	0	8	9
175	R:R:A327	R:R:F333	8.32	No	Yes	0	7	8
176	R:R:W332	R:R:Y330	14.47	Yes	Yes	0	6	8
177	R:R:F333	R:R:W332	5.01	Yes	Yes	0	8	6
178	R:R:G64	R:R:L67	3.42	No	No	0	8	7
179	R:R:C139	R:R:V227	3.42	No	No	0	7	7
180	R:R:F75	R:R:H74	3.39	No	No	0	5	5
181	R:R:M101	R:R:P102	3.35	Yes	No	0	7	8
182	R:R:L287	R:R:P288	3.28	No	No	0	7	9
183	R:R:A281	R:R:I325	3.25	No	No	0	6	8
184	R:R:A61	R:R:M101	3.22	No	Yes	0	7	7
185	R:R:A281	R:R:M321	3.22	No	No	0	6	6
186	R:R:F328	R:R:F333	3.22	No	Yes	0	6	8
187	R:R:A336	R:R:L78	3.15	No	No	0	7	8
188	R:R:A280	R:R:L284	3.15	No	No	0	5	5
189	R:R:I337	R:R:S71	3.1	No	Yes	0	7	8
190	R:R:I176	R:R:S129	3.1	No	No	0	3	5
191	R:R:F329	R:R:Y330	3.09	No	Yes	0	6	8
192	R:R:I72	R:R:V86	3.07	Yes	No	0	7	8
193	R:R:I235	R:R:V149	3.07	No	No	0	8	8
194	R:R:I229	R:R:T225	3.04	No	No	0	5	5
195	R:R:K261	R:R:V264	3.04	No	Yes	0	3	3
196	R:R:A243	R:R:E268	3.02	No	Yes	0	4	6
197	R:R:L89	R:R:S134	3	Yes	No	0	9	9
198	R:R:G111	R:R:R107	3	No	No	0	4	4
199	R:R:L283	R:R:V279	2.98	No	No	0	5	8
200	R:R:G179	R:R:Y178	2.9	No	Yes	0	7	5
201	R:R:I72	R:R:L73	2.85	Yes	No	0	7	3
202	R:R:E268	R:R:V264	2.85	Yes	Yes	0	6	3
203	R:R:I291	R:R:L287	2.85	No	No	0	6	7
204	R:R:E309	R:R:T305	2.82	No	No	0	5	3
205	R:R:G116	R:R:W113	2.81	No	Yes	0	7	8
206	R:R:D292	R:R:I295	2.8	No	No	0	4	4
207	R:R:L324	R:R:L60	2.77	No	No	0	6	5
208	R:R:L222	R:R:L226	2.77	No	No	0	5	4
209	R:R:A271	R:R:F236	2.77	No	Yes	0	7	6
210	R:R:A272	R:R:F236	2.77	No	Yes	0	7	6
211	R:R:A297	R:R:F298	2.77	No	No	0	4	4
212	R:R:C125	R:R:Y184	2.69	No	No	0	5	4
213	R:R:F140	R:R:S171	2.64	No	No	0	7	6
214	R:R:C91	R:R:W172	2.61	No	Yes	0	7	9
215	R:R:A92	R:R:W172	2.59	No	Yes	0	8	9
216	R:R:F282	R:R:T225	2.59	No	No	0	9	5
217	R:R:V53	R:R:Y317	2.52	No	No	0	5	6
218	R:R:V96	R:R:Y316	2.52	No	Yes	0	7	7
219	R:R:F180	R:R:I176	2.51	No	No	0	4	3
220	R:R:K270	R:R:R267	2.48	No	No	0	8	5
221	R:R:F170	R:R:L174	2.44	No	Yes	0	4	3
222	R:R:F236	R:R:L237	2.44	Yes	No	0	6	3
223	R:R:I235	R:R:Y146	2.42	No	Yes	0	8	8
224	R:R:I216	R:R:Y178	2.42	No	Yes	0	4	5
225	R:R:I310	R:R:Y306	2.42	No	No	0	4	1
226	R:R:E110	R:R:R107	2.33	No	No	0	4	4
227	R:R:L78	R:R:W332	2.28	No	Yes	0	8	6
228	R:R:F84	R:R:H79	2.26	No	No	0	4	7
229	R:R:G203	R:R:G204	2.11	No	No	0	4	3
230	R:R:G165	R:R:S164	1.86	No	No	0	2	7
231	R:R:A320	R:R:A61	1.79	No	No	0	7	7
232	R:R:A239	R:R:A271	1.79	No	No	0	8	7
233	R:R:C63	R:R:V59	1.71	No	No	0	5	5
234	R:R:C139	R:R:V143	1.71	No	No	0	7	7
235	R:R:C167	R:R:V163	1.71	No	No	0	5	6
236	R:R:G276	R:R:L275	1.71	No	No	0	5	7
237	R:R:A90	R:R:V68	1.7	No	No	0	9	9
238	R:R:A297	R:R:V209	1.7	No	No	0	4	3
239	R:R:A154	R:R:T157	1.68	No	No	0	4	4
240	R:R:K335	R:R:P331	1.67	No	No	0	5	5
241	R:R:L311	R:R:P288	1.64	No	No	0	5	9
242	R:R:L324	R:R:P323	1.64	No	No	0	6	9
243	R:R:D151	R:R:P152	1.61	Yes	No	0	5	8
244	R:R:S71	R:R:T70	1.6	Yes	No	0	8	5
245	R:R:S233	R:R:T230	1.6	No	No	0	4	3
246	R:R:T230	R:R:V231	1.59	No	Yes	0	3	7
247	R:R:I72	R:R:V68	1.54	Yes	No	0	7	9
248	R:R:I141	R:R:V86	1.54	Yes	No	0	9	8
249	R:R:I314	R:R:V315	1.54	No	Yes	0	7	7
250	R:R:F54	R:R:G57	1.51	Yes	No	0	7	6
251	R:R:F56	R:R:G57	1.51	No	No	0	4	6
252	R:R:L67	R:R:S71	1.5	No	Yes	0	7	8
253	R:R:L122	R:R:S118	1.5	No	No	0	5	3
254	R:R:L174	R:R:S177	1.5	Yes	No	0	3	3
255	R:R:L60	R:R:V59	1.49	No	No	0	5	5
256	R:R:D117	R:R:S118	1.47	No	No	0	3	3
257	R:R:D151	R:R:S150	1.47	Yes	No	0	5	6
258	R:R:K266	R:R:K270	1.44	No	No	0	4	8
259	R:R:E110	R:R:V109	1.43	No	No	0	4	5
260	R:R:Q244	R:R:V264	1.43	No	Yes	0	4	3
261	R:R:E247	R:R:V264	1.43	No	Yes	0	4	3
262	R:R:G204	R:R:W113	1.41	No	Yes	0	3	8
263	R:R:P331	R:R:Y330	1.39	No	Yes	0	5	8
264	R:R:L173	R:R:L174	1.38	No	Yes	0	4	3
265	R:R:N245	R:R:Q241	1.32	No	No	0	3	4
266	R:R:N245	R:R:Q242	1.32	No	No	0	3	6
267	R:R:N245	R:R:Q244	1.32	No	No	0	3	4
268	R:R:K273	R:R:R269	1.24	No	No	0	7	5
269	R:R:F301	R:R:L299	1.22	No	No	0	2	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.048	10	1	0
2	R:R:F54	10.5414	7	0	7
3	R:R:N65	7.924	5	2	9
4	R:R:S71	2.87	4	0	8
5	R:R:I72	3.49	4	0	7
6	R:R:L89	5.8225	4	1	9
7	R:R:F94	6.8075	4	2	7
8	R:R:M101	5.918	5	0	7
9	R:R:W113	7.86667	6	0	8
10	R:R:H123	5.765	4	0	5
11	R:R:D127	10.765	4	1	6
12	R:R:F130	5.4175	4	0	7
13	R:R:Y132	5.34667	6	1	5
14	R:R:H137	6.984	5	1	7
15	R:R:I141	3.9275	4	1	9
16	R:R:D144	6.5975	4	4	8
17	R:R:R145	6.4525	4	1	9
18	R:R:Y146	7.37	4	1	8
19	R:R:D151	2.82	4	0	5
20	R:R:Y155	4.87	5	4	7
21	R:R:W172	6.3525	4	1	9
22	R:R:L174	2.8525	4	0	3
23	R:R:Y178	4.446	5	0	5
24	R:R:N217	7.55	5	1	6
25	R:R:V231	4.955	4	1	7
26	R:R:Y232	6.58	4	1	9
27	R:R:F236	2.87	4	0	6
28	R:R:V264	2.1875	4	0	3
29	R:R:E268	5.0425	4	0	6
30	R:R:W286	7.28714	7	1	8
31	R:R:Y289	7.5925	4	1	6
32	R:R:F290	8.582	5	1	7
33	R:R:V315	5.175	4	1	7
34	R:R:Y316	6.125	6	1	7
35	R:R:Y326	5.4175	4	1	9
36	R:R:Y330	7.0525	4	0	8
37	R:R:W332	7.135	4	0	6
38	R:R:F333	5.4475	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	63.2627	12.6	Yes	Yes	1	0	7
2	R:R:V100	R:R:Y316	27.1852	5.05	No	Yes	1	7	7
3	R:R:H123	R:R:V100	46.065	5.54	Yes	No	0	5	7
4	R:R:H123	R:R:W113	36.0446	7.41	Yes	Yes	0	5	8
5	R:R:R107	R:R:W113	18.273	12	No	Yes	0	4	8
6	R:R:E110	R:R:R107	13.0484	2.33	No	No	0	4	4
7	L:L:?1	R:R:D127	21.9474	24.81	Yes	Yes	1	0	6
8	R:R:D127	R:R:V100	21.1887	4.38	Yes	No	1	6	7
9	R:R:M101	R:R:Y316	30.6682	3.59	Yes	Yes	0	7	7
10	R:R:F54	R:R:M101	25.5228	12.44	Yes	Yes	0	7	7
11	R:R:F54	R:R:G57	15.2912	1.51	Yes	No	0	7	6
12	R:R:F56	R:R:G57	14.3611	1.51	No	No	0	4	6
13	R:R:F56	R:R:L60	14.0313	4.87	No	No	0	4	5
14	R:R:L324	R:R:L60	13.0615	2.77	No	No	0	6	5
15	R:R:L324	R:R:P323	12.9362	1.64	No	No	0	6	9
16	R:R:N65	R:R:P323	11.8741	6.52	Yes	No	2	9	9
17	L:L:?1	R:R:W286	75.2688	4.9	Yes	Yes	1	0	8
18	R:R:N318	R:R:W286	99.8681	6.78	No	Yes	1	9	8
19	R:R:N318	R:R:N322	100	9.54	No	No	1	9	9
20	R:R:L138	R:R:N322	80.909	5.49	No	No	1	8	9
21	R:R:L138	R:R:Y326	88.8053	7.03	No	Yes	1	8	9
22	R:R:I141	R:R:Y326	26.2616	3.63	Yes	Yes	1	9	9
23	R:R:I141	R:R:V86	14.5194	1.54	Yes	No	0	9	8
24	R:R:I72	R:R:V86	13.2133	3.07	Yes	No	0	7	8
25	R:R:A90	R:R:V68	13.2397	1.7	No	No	0	9	9
26	R:R:A90	R:R:N65	12.5206	4.69	No	Yes	0	9	9
27	R:R:R145	R:R:Y326	59.6411	6.17	Yes	Yes	1	9	9
28	R:R:R145	R:R:Y330	36.7307	9.26	Yes	Yes	0	9	8
29	R:R:W332	R:R:Y330	29.2368	14.47	Yes	Yes	0	6	8
30	R:R:F333	R:R:W332	20.9315	5.01	Yes	Yes	0	8	6
31	R:R:F328	R:R:F333	16.5578	3.22	No	Yes	0	6	8
32	R:R:F328	R:R:L67	14.7701	3.65	No	No	0	6	7
33	R:R:L67	R:R:S71	11.1551	1.5	No	Yes	0	7	8
34	R:R:I141	R:R:L85	23.1875	4.28	Yes	No	0	9	7
35	R:R:D144	R:R:L85	12.6525	4.07	Yes	No	0	8	7
36	R:R:L89	R:R:N322	18.5698	9.61	Yes	No	1	9	9
37	R:R:H137	R:R:L89	24.0055	5.14	Yes	Yes	1	7	9
38	R:R:V96	R:R:Y316	24.9951	2.52	No	Yes	0	7	7
39	R:R:F130	R:R:V96	22.2376	5.24	Yes	No	0	7	7
40	L:L:?1	R:R:Y132	12.8043	5.04	Yes	Yes	1	0	5
41	R:R:F290	R:R:W286	21.07	5.01	Yes	Yes	1	7	8
42	R:R:F221	R:R:W286	10.7527	14.03	No	Yes	1	8	8
43	R:R:F221	R:R:L135	10.3239	6.09	No	No	0	8	7
44	R:R:H137	R:R:S171	10.601	8.37	Yes	No	0	7	6
45	R:R:R145	R:R:Y232	41.5595	4.12	Yes	Yes	1	9	9
46	R:R:M228	R:R:Y232	10.5614	4.79	No	Yes	1	8	9
47	R:R:S142	R:R:Y232	26.4134	12.72	No	Yes	1	9	9
48	R:R:S142	R:R:V231	25.2985	4.85	No	Yes	1	9	7
49	R:R:V231	R:R:Y146	18.2664	8.83	Yes	Yes	1	7	8
50	R:R:S150	R:R:Y146	11.1551	5.09	No	Yes	0	6	8
51	L:L:?1	R:R:N217	18.0091	8.86	Yes	Yes	1	0	6
52	R:R:N217	R:R:Y178	10.878	4.65	Yes	Yes	0	6	5
53	R:R:F218	R:R:F290	30.6682	10.72	No	Yes	0	5	7
54	R:R:F218	R:R:F294	21.6043	10.72	No	No	0	5	5
55	R:R:F294	R:R:F298	12.4217	4.29	No	No	0	5	4
56	R:R:F290	R:R:N217	13.5431	4.83	Yes	Yes	1	7	6
57	L:L:?1	R:R:Y289	23.9726	15.12	Yes	Yes	1	0	6
58	R:R:L311	R:R:Y289	30.7804	3.52	No	Yes	0	5	6
59	R:R:D292	R:R:L311	21.545	8.14	No	No	0	4	5
60	R:R:D292	R:R:T303	16.8481	8.67	No	No	0	4	4
61	R:R:V315	R:R:W286	13.266	7.36	Yes	Yes	1	7	8
62	R:R:W286	R:R:Y132	12.0061	6.75	Yes	Yes	1	8	5
63	R:R:V315	R:R:Y289	11.9071	3.79	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D127	24.81	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V128	4.81	1	Yes	No	0	4	0	1
L:L:?1	R:R:C131	5.12	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y132	5.04	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N217	8.86	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W286	4.9	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y289	15.12	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V312	11.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:V315	8.01	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y316	12.6	1	Yes	Yes	0	7	0	1
R:R:D127	R:R:V100	4.38	1	Yes	No	6	7	1	2
R:R:V100	R:R:Y316	5.05	1	No	Yes	7	7	2	1
R:R:M101	R:R:Y316	3.59	0	Yes	Yes	7	7	2	1
R:R:C131	R:R:D127	4.67	1	No	Yes	7	6	1	1
R:R:D127	R:R:Y316	9.2	1	Yes	Yes	6	7	1	1
R:R:I183	R:R:V128	4.61	0	No	No	5	4	2	1
R:R:F136	R:R:Y132	4.13	0	No	Yes	5	5	2	1
R:R:N217	R:R:Y132	6.98	1	Yes	Yes	6	5	1	1
R:R:V220	R:R:Y132	5.05	0	No	Yes	5	5	2	1
R:R:W286	R:R:Y132	6.75	1	Yes	Yes	8	5	1	1
R:R:F290	R:R:Y132	4.13	1	Yes	Yes	7	5	2	1
R:R:N217	R:R:Y178	4.65	1	Yes	Yes	6	5	1	2
R:R:V220	R:R:Y178	7.57	0	No	Yes	5	5	2	2
R:R:N217	R:R:W213	12.43	1	Yes	No	6	7	1	2
R:R:F290	R:R:N217	4.83	1	Yes	Yes	7	6	2	1
R:R:F221	R:R:W286	14.03	1	No	Yes	8	8	2	1
R:R:F221	R:R:F290	18.22	1	No	Yes	8	7	2	2
R:R:S285	R:R:W286	6.18	1	No	Yes	8	8	2	1
R:R:N318	R:R:S285	5.96	1	No	No	9	8	2	2
R:R:F290	R:R:W286	5.01	1	Yes	Yes	7	8	2	1
R:R:V315	R:R:W286	7.36	1	Yes	Yes	7	8	1	1
R:R:N318	R:R:W286	6.78	1	No	Yes	9	8	2	1
R:R:Y289	R:R:Y308	7.94	1	Yes	No	6	3	1	2
R:R:L311	R:R:Y289	3.52	0	No	Yes	5	6	2	1
R:R:V315	R:R:Y289	3.79	1	Yes	Yes	7	6	1	1
R:R:V312	R:R:Y308	5.05	1	No	No	5	3	1	2
R:R:V312	R:R:Y316	3.79	1	No	Yes	5	7	1	1
R:R:V96	R:R:Y316	2.52	0	No	Yes	7	7	2	1
R:R:I314	R:R:V315	1.54	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8PM2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	245
Number of Links	269
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	5
Number of Nodes involved in Communities	44
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	32961
Length Of Smallest Path	3
Average Path Length	11.4514
Length of Longest Path	23
Minimum Path Strength	1.32
Average Path Strength	6.57725
Maximum Path Strength	21.255
Minimum Path Correlation	0.7
Average Path Correlation	0.91795
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	47.2817
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5547
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8IA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8IA
Name	~{N},~{N}-dimethylcyclohexanamine
Synonyms
Identifier
Formula	C8 H17 N
Molecular Weight	127.227
SMILES
PubChem	7415
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD08
Sequence	>8PM2_nogp_Chain_R I L Y A V F G F G A V L A V C G N L L V M T S I L H F R Q L H S P A N F L V A S L A C A D F L V G V M V M P F S M V R S V E G C W Y F G D S Y C K L H T C F D V S F C Y C S L F H L C F I S V D R Y I A V S D P L A Y P T R F T A S V S G K C I T F S W L L S I S Y G F S L I Y G G C Q I A V N Q T W V F I N F S V F L I P T L V M I T V Y S K I F L I A K Q Q A Q N I E K M S K D R V A K R E R K A A K T L G I A V A A F L L S W L P Y F I D S F I D A F L G F I T P T Y V Y E I L V W I V Y Y N S A M N P L I Y A F F Y P W F R K A I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8PM2	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-	Gs/β1/γ2	2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762
	8PM2 (No Gprot)	A	Amine	Trace Amine Receptors	TA7	Mus musculus	DMCH	-		2.92	2023-08-09	doi.org/10.1101/2023.07.07.547762

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8PM2_nogp.zip

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