Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:R30 9.585455
2R:R:F40 8.79405
3R:R:Y45 5.36167617
4R:R:N56 5.9875409
5R:R:M63 5.0025436
6R:R:D74 8.385438
7R:R:Y76 6.994507
8R:R:R77 12.176538
9R:R:H79 7.43469
10R:R:S81 6.52409
11R:R:F87 9.31333617
12R:R:F93 7.245416
13R:R:W94 7.545617
14R:R:W102 8.33125819
15R:R:F104 10.385417
16R:R:V112 5.745415
17R:R:Y116 11.078516
18R:R:N119 7.445418
19R:R:Y121 6.1375477
20R:R:Y135 7.8375428
21R:R:L136 4.0925425
22R:R:R148 7.992526
23R:R:V160 5.78407
24R:R:W161 6.37509
25R:R:T168 6.3625446
26R:R:D171 9.845444
27R:R:F174 7.3275484
28R:R:R183 10.8825403
29R:R:Y190 9.658584
30R:R:F199 8.655405
31R:R:Y219 7.1175408
32R:R:H232 9.284594
33R:R:F248 7.42333619
34R:R:W252 8.60571719
35R:R:Y255 10.1425407
36R:R:I259 7.235405
37R:R:D262 7.26405
38R:R:E288 8.42415
39R:R:F292 7.68833617
40R:R:H294 7.75167619
41R:R:C295 6.755419
42R:R:N298 8.502539
43R:R:Y302 12.972539
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:C28 R:R:N278 29.37136.3NoNo093
2R:R:N278 R:R:R30 32.15477.23NoYes535
3R:R:H281 R:R:R30 49.319514.67NoYes045
4R:R:D262 R:R:H281 52.06687.56YesNo054
5R:R:D262 R:R:Q200 29.06529.14YesNo055
6R:R:I259 R:R:Q200 38.62884.12YesNo055
7R:R:I259 R:R:Y255 72.439914.51YesYes057
8R:R:W252 R:R:Y255 62.91957.72YesYes097
9R:R:F292 R:R:W252 41.17824.01YesYes179
10R:R:F292 R:R:Y45 31.72266.19YesYes177
11R:R:L41 R:R:Y45 30.81164.69NoYes067
12R:R:F40 R:R:L41 26.58793.65YesNo056
13R:R:F40 R:R:I286 13.43086.28YesNo056
14R:R:I286 R:R:N37 11.21279.91NoNo063
15R:R:D262 R:R:I284 28.72324.2YesNo054
16R:R:I259 R:R:I284 30.09514.42YesNo054
17R:R:E288 R:R:Y255 17.892114.59YesYes057
18R:R:E288 R:R:W94 12.02655.45YesYes157
19R:R:W94 R:R:Y45 13.931310.61YesYes177
20R:R:H294 R:R:W252 30.509116.93YesYes199
21R:R:H294 R:R:N119 16.26826.38YesYes198
22R:R:D84 R:R:N119 33.78225.39NoYes198
23R:R:D84 R:R:N56 66.32226.73NoYes099
24R:R:G52 R:R:N56 40.4763.39NoYes089
25R:R:G52 R:R:V88 17.51763.68NoNo086
26R:R:I53 R:R:V88 14.61544.61NoNo056
27R:R:C295 R:R:H294 16.26827.37YesYes199
28R:R:C295 R:R:D84 33.78229.34YesNo199
29R:R:C296 R:R:G52 20.41261.96NoNo078
30R:R:C296 R:R:T51 11.7066.76NoNo075
31R:R:F248 R:R:W252 97.357111.02YesYes199
32R:R:F248 R:R:L127 1008.53YesNo098
33R:R:L127 R:R:L80 86.21995.54NoNo089
34R:R:L80 R:R:N298 48.04485.49NoYes099
35R:R:N298 R:R:P299 17.49964.89YesNo099
36R:R:N56 R:R:P299 21.28764.89YesNo099
37R:R:N298 R:R:S81 20.27585.96YesYes099
38R:R:N56 R:R:S81 31.62188.94YesYes099
39R:R:N298 R:R:Y302 25.86789.3YesYes399
40R:R:I60 R:R:S81 14.75953.1NoYes079
41R:R:M63 R:R:Y302 21.80615.99YesYes369
42R:R:K68 R:R:M63 13.32641.44NoYes066
43R:R:I126 R:R:L80 73.49138.56NoNo079
44R:R:H79 R:R:I126 31.28333.98YesNo097
45R:R:H79 R:R:V156 23.70379.69YesNo695
46R:R:V156 R:R:Y76 22.93325.05NoYes057
47R:R:D133 R:R:Y76 40.753311.49NoYes087
48R:R:I126 R:R:V160 41.65716.14NoYes077
49R:R:F129 R:R:V160 29.78543.93NoYes057
50R:R:F129 R:R:Y76 24.15748.25NoYes057
51R:R:D133 R:R:R148 30.195915.48NoYes286
52R:R:I245 R:R:L127 27.74745.71NoNo078
53R:R:I215 R:R:I245 26.70324.42NoNo077
54R:R:I215 R:R:S131 24.708310.84NoNo079
55R:R:S131 R:R:Y219 23.73258.9NoYes098
56R:R:T241 R:R:Y219 11.71327.49NoYes078
57R:R:N298 R:R:R77 15.980116.87YesYes398
58R:R:L301 R:R:R77 11.06154.86NoYes078
59R:R:F87 R:R:W94 28.21554.01YesYes177
60R:R:V112 R:R:W94 53.48913.68YesYes157
61R:R:V112 R:R:W102 39.33466.13YesYes159
62R:R:V177 R:R:W102 27.0744.9NoYes049
63R:R:E179 R:R:V177 20.47752.85NoNo024
64R:R:E179 R:R:Y184 18.810326.93NoNo025
65R:R:Y103 R:R:Y184 17.1367.94NoNo035
66R:R:N101 R:R:Y103 15.45444.65NoNo043
67R:R:N101 R:R:R183 13.76576.03NoYes043
68R:R:L120 R:R:W252 35.25495.69NoYes079
69R:R:H203 R:R:L120 50.05049NoNo047
70R:R:H203 R:R:Y121 82.29513.27NoYes047
71R:R:Q202 R:R:Y121 74.74794.51NoYes737
72R:R:F199 R:R:Q202 72.35718.2YesNo053
73R:R:F199 R:R:P170 25.914610.11YesNo058
74R:R:P170 R:R:R188 20.93128.65NoNo085
75R:R:D171 R:R:R188 36.698814.29YesNo045
76R:R:W252 R:R:Y256 43.12265.79YesNo098
77R:R:H203 R:R:Y256 34.749.8NoNo048
78R:R:F199 R:R:Y190 41.527412.38YesYes054
79R:R:R188 R:R:Y190 21.096818.52NoYes054
80R:R:D171 R:R:H113 10.5256.3YesNo046
81R:R:D171 R:R:T168 15.76775.78YesYes446
82R:R:R134 R:R:T241 10.06776.47NoNo097
83R:R:L136 R:R:R148 24.79124.86YesYes256
84R:R:H140 R:R:L136 18.14423.86NoYes265
85R:R:H140 R:R:Y135 11.35688.71NoYes268
86R:R:H232 R:R:I138 13.61442.65YesNo048
87R:R:C28 R:R:E277 23.552512.15NoNo092
88R:R:E277 R:R:I265 20.62876.83NoNo023
89R:R:F276 R:R:I265 11.81055.02NoNo013
90R:R:F87 R:R:N119 21.352413.29YesYes178
91R:R:C295 R:R:F87 21.35245.59YesYes197
92R:R:L120 R:R:Y116 17.247616.41NoYes076
93R:R:F292 R:R:W94 17.79498.02YesYes177
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9MDU
Class A
SubFamily Protein
Type Chemokine
SubType CXCR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.9
Date 2025-09-10
D.O.I. To be published
Net Summary
Imin 3.68
Number of Linked Nodes 267
Number of Links 306
Number of Hubs 43
Number of Links mediated by Hubs 157
Number of Communities 9
Number of Nodes involved in Communities 55
Number of Links involved in Communities 75
Path Summary
Number Of Nodes in MetaPath 94
Number Of Links MetaPath 93
Number of Shortest Paths 79716
Length Of Smallest Path 3
Average Path Length 13.7242
Length of Longest Path 29
Minimum Path Strength 1.52
Average Path Strength 7.32215
Maximum Path Strength 20.14
Minimum Path Correlation 0.7
Average Path Correlation 0.920672
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 44.9653
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.4695
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • coreceptor activity   • signaling receptor activity   • cytoskeletal protein binding   • myosin light chain binding   • protein binding   • binding   • myosin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • G protein-coupled chemoattractant receptor activity   • C-X-C motif chemokine 12 receptor activity   • C-X-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • virus receptor activity   • exogenous protein binding   • C-C chemokine receptor activity   • ubiquitin binding   • ubiquitin-like protein binding   • actin binding   • developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion
Gene OntologyBiological Process• developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion   • biological regulation   • cellular process   • apoptotic process   • cell death   • programmed cell death   • membrane organization   • cellular component organization   • myelination   • myelin maintenance   • axon ensheathment   • ensheathment of neurons   • plasma membrane organization   • cellular component organization or biogenesis   • endomembrane system organization   • cell chemotaxis   • cellular response to stimulus   • chemotaxis   • dendritic cell chemotaxis   • response to stimulus   • response to external stimulus   • leukocyte migration   • dendritic cell migration   • cellular response to chemical stimulus   • taxis   • immune system process   • response to chemical   • mononuclear cell migration   • cell migration   • cell motility   • leukocyte chemotaxis   • locomotion   • response to decreased oxygen levels   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • neurogenesis   • cellular developmental process   • cell differentiation   • immune response   • cell surface receptor signaling pathway   • chemokine (C-X-C motif) ligand 12 signaling pathway   • signaling   • CXCL12-activated CXCR4 signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • cell communication   • response to peptide   • G protein-coupled receptor signaling pathway   • cellular response to cytokine stimulus   • signal transduction   • C-X-C chemokine receptor CXCR4 signaling pathway   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • regulation of multicellular organismal development   • regulation of developmental process   • positive regulation of biological process   • vasculature development   • regulation of vasculature development   • circulatory system development   • positive regulation of developmental process   • positive regulation of vasculature development   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of macrophage migration inhibitory factor signaling pathway   • positive regulation of response to cytokine stimulus   • positive regulation of response to stimulus   • macrophage migration inhibitory factor signaling pathway   • positive regulation of cellular process   • regulation of signaling   • regulation of macrophage migration inhibitory factor signaling pathway   • regulation of cytokine-mediated signaling pathway   • regulation of response to cytokine stimulus   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of cytokine-mediated signaling pathway   • positive regulation of signaling   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to external biotic stimulus   • response to virus   • response to biotic stimulus   • defense response   • inflammatory response   • positive regulation of nervous system development   • cell development   • regulation of neurogenesis   • regulation of cell differentiation   • regulation of gliogenesis   • positive regulation of gliogenesis   • regulation of cell development   • regulation of nervous system development   • gliogenesis   • positive regulation of cell differentiation   • positive regulation of neurogenesis   • positive regulation of oligodendrocyte differentiation   • positive regulation of cell development   • regulation of glial cell differentiation   • positive regulation of glial cell differentiation   • oligodendrocyte differentiation   • glial cell differentiation   • regulation of oligodendrocyte differentiation   • cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell leading edge   • intracellular anatomical structure   • cytoplasm   • anchoring junction   • cell junction   • intracellular organelle   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • lysosome   • protein-containing complex   • cytoplasmic vesicle   • intracellular vesicle   • early endosome   • endosome   • endomembrane system   • late endosome
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP61073
Sequence
>9MDU_Chain_R
EPCFREENA NFNKIFLPT IYSIIFLTG IVGNGLVIL VMGYQKKLR 
SMTDKYRLH LSVADLLFV ITLPFWAVD AVANWYFGN FLCKAVHVI 
YTVNLYSSV LILAFISLD RYLAIVHAT NSQRPRKLL AEKVVYVGV 
WIPALLLTI PDFIFANVS EADDRYICD RFYPNDLWV VVFQFQHIM 
VGLILPGIV ILSCYCIII SKLSHSKGH QKRKALKTT VILILAFFA 
CWLPYYIGI SIDSFILLE IIKQGCEFE NTVHKWISI TEALAFFHC 
CLNPILYAF LG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3ODUAProteinChemokineCXCR4Homo sapiensIT1t--2.52010-10-27doi.org/10.1126/science.1194396
3OE0AProteinChemokineCXCR4Homo sapiensCVX15--2.92010-10-27doi.org/10.1126/science.1194396
3OE6AProteinChemokineCXCR4Homo sapiensIT1t--3.22010-10-27doi.org/10.1126/science.1194396
3OE8AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
3OE9AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
4RWSAProteinChemokineCXCR4Homo sapiensvMIP-II--3.12015-02-11doi.org/10.1126/science.1261064
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8K3Z (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-2.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8ZPLAProteinChemokineCXCR4Homo sapiensHF51116--3.012025-02-26doi.org/10.1073/pnas.2425795122
8ZPMAProteinChemokineCXCR4Homo sapiensAMD070--3.22025-02-26doi.org/10.1073/pnas.2425795122
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100--3.312025-02-26doi.org/10.1073/pnas.2425795122
8YU7AProteinChemokineCXCR4Homo sapiens---3.012025-03-05doi.org/10.1016/j.celrep.2025.115255
9MDUAProteinChemokineCXCR4Homo sapiens---2.92025-09-10To be published
9ME1AProteinChemokineCXCR4Homo sapiensCXCL12--3.372025-09-10To be published
9MEJAProteinChemokineCXCR4Homo sapiensGp120--3.992025-09-10To be published
9MENAProteinChemokineCXCR4Homo sapiensGp120 (V3 loop)--3.572025-09-10To be published
9METAProteinChemokineCXCR4Homo sapiensGp120; CD4--5.652025-09-10To be published
9MEUAProteinChemokineCXCR4Homo sapiensCXCL12--3.462025-09-10To be published
8U4NAProteinChemokineCXCR4Homo sapiens--Gi1/β1/γ22.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4N (No Gprot) AProteinChemokineCXCR4Homo sapiens--2.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ23.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4O (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-3.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100-3.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-Fab-Gi1/β1/γ23.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4Q (No Gprot) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4RAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.12024-03-13doi.org/10.1101/2024.02.09.579708
8U4SAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4TAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.382024-03-13doi.org/10.1038/s41594-024-01397-1




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