Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 3.2449
2A:A:Y37 6.775424
3A:A:H41 5.152516
4A:A:L45 5.2375418
5A:A:N50 6.86254109
6A:A:K53 4.005419
7A:A:I207 3.79429
8A:A:F212 5.538519
9A:A:V214 5.3525416
10A:A:F219 6.604518
11A:A:H220 8.616527
12A:A:M221 3.65857718
13A:A:F222 9.072527
14A:A:Q227 5.312529
15A:A:R231 5.335429
16A:A:K233 4.77857729
17A:A:W234 6.83667629
18A:A:I235 3.9525429
19A:A:C237 3.5975428
20A:A:F238 6.42429729
21A:A:I244 3.23428
22A:A:I245 3.386517
23A:A:V247 4.534517
24A:A:V248 3.4625457
25A:A:D252 4.544108
26A:A:Y253 6.605458
27A:A:L270 4.42506
28A:A:F273 4.93667659
29A:A:W277 9.118556
30A:A:W281 6.582525
31A:A:L282 4.555429
32A:A:I288 6.336519
33A:A:F290 5.0425819
34A:A:L291 3.098558
35A:A:N292 5.495419
36A:A:Q294 5.6025456
37A:A:L297 4.434558
38A:A:V301 4.035457
39A:A:F315 7.292556
40A:A:Y318 7.0425456
41A:A:Y339 6.826553
42A:A:F340 8.15167657
43A:A:R342 6.16654
44A:A:E344 7.86455
45A:A:F345 5.98333658
46A:A:S349 4.635457
47A:A:C359 3.865455
48A:A:Y360 8.91429718
49A:A:F363 6.78555
50A:A:T364 6.7725419
51A:A:R374 7.906514
52A:A:F376 4.94333618
53A:A:I383 3.474518
54A:A:H387 4.0375418
55A:A:L388 4.605408
56A:A:Y391 6.92286714
57A:A:L394 4.2975408
58B:B:L7 4.47254128
59B:B:I18 3.05407
60B:B:D27 5.415408
61B:B:L30 4425
62B:B:I33 2.66423
63B:B:I37 4.1725472
64B:B:V40 5.3575473
65B:B:M45 3.2575474
66B:B:L51 6.82449
67B:B:H54 9.076549
68B:B:K57 9.844529
69B:B:Y59 10.326528
70B:B:W63 5.57747
71B:B:V71 2.9975408
72B:B:S72 6.82449
73B:B:Q75 8.45429
74B:B:D76 6.872529
75B:B:L79 4.8375487
76B:B:I81 4.288587
77B:B:W82 8.47649
78B:B:N88 4.974547
79B:B:K89 4.91286749
80B:B:H91 5.2725485
81B:B:I93 5.0475487
82B:B:L95 4.766588
83B:B:W99 7.93729
84B:B:Y105 4.02333606
85B:B:N110 6.2025434
86B:B:Y111 6.598534
87B:B:C114 4.692588
88B:B:L117 3.2629
89B:B:C121 4.135438
90B:B:I123 4.388536
91B:B:Y124 5.19333686
92B:B:V133 5.025484
93B:B:E138 7.1925486
94B:B:L139 6.142509
95B:B:H142 5.69143739
96B:B:Y145 5.41778928
97B:B:L146 4.436537
98B:B:C149 4.034538
99B:B:R150 7.055436
100B:B:F151 4.55286739
101B:B:L152 4.5425403
102B:B:I157 4.81333637
103B:B:T159 6.11167639
104B:B:D163 7.49439
105B:B:W169 8.76833638
106B:B:F180 6.53667637
107B:B:H183 7.90833639
108B:B:D186 5.3625429
109B:B:L190 4.132535
110B:B:F199 6.38429739
111B:B:V200 6.87466
112B:B:S201 4.915439
113B:B:C204 4.3575427
114B:B:D205 7.7475439
115B:B:S207 4.475435
116B:B:K209 8.002536
117B:B:W211 9.504538
118B:B:C218 4.4775435
119B:B:Q220 7.385467
120B:B:F222 6.494568
121B:B:H225 9.10143769
122B:B:D228 7.0175429
123B:B:I229 5.6625467
124B:B:I232 6.1725468
125B:B:F234 5.61405
126B:B:F235 6.85333626
127B:B:F241 6.04429766
128B:B:T243 5.37568
129B:B:D247 9.656569
130B:B:T249 5.74566
131B:B:R251 9.175668
132B:B:F253 6.874566
133B:B:D254 3.7975409
134B:B:L255 3.38566
135B:B:R256 8.7575409
136B:B:D258 8.718567
137B:B:M262 3.1975424
138B:B:Y264 5.685625
139B:B:I269 3.84424
140B:B:C271 4.22425
141B:B:I273 4.515406
142B:B:F278 5.3627
143B:B:R283 6.56571779
144B:B:L285 4.79426
145B:B:Y289 6.39527
146B:B:D290 7.0925426
147B:B:N295 7.285426
148B:B:W297 7.6525428
149B:B:L300 4.115476
150B:B:K301 5.918575
151B:B:R304 6.815425
152B:B:H311 8.88599
153B:B:R314 11.712528
154B:B:V327 4.97476
155B:B:T329 5.8275498
156B:B:W332 10.98729
157B:B:D333 8.345499
158B:B:F335 6.8225494
159B:B:L336 5.004547
160B:B:K337 8.405496
161B:B:I338 4.6975445
162B:B:W339 8.302599
163G:G:Q18 6.6225439
164G:G:R27 6.575468
165G:G:D48 6.642579
166G:G:L50 4.005479
167G:G:L51 4.616576
168G:G:F61 5.33625848
169R:R:P20 5.072515
170R:R:Y24 6.3975418
171R:R:L32 5.6875415
172R:R:N35 6.1125419
173R:R:E51 6.62667616
174R:R:L52 4.3025417
175R:R:Y55 4.10429717
176R:R:N58 7.275419
177R:R:S62 4.534518
178R:R:D63 6.338519
179R:R:L66 7.128517
180R:R:I67 5615
181R:R:L70 3.084518
182R:R:W73 4.1875416
183R:R:Y76 7.5225416
184R:R:Y77 10.198515
185R:R:W83 4.77375818
186R:R:C90 4.938519
187R:R:F93 6.1825415
188R:R:F97 5.84517
189R:R:Y102 5.515407
190R:R:V103 6.0475417
191R:R:F107 6.535617
192R:R:V111 4.0125418
193R:R:D114 9.08518
194R:R:R115 6.002519
195R:R:P122 4.27418
196R:R:P126 5.07515
197R:R:W142 5.91519
198R:R:N149 3.9854116
199R:R:H165 8.524513
200R:R:Y169 3.452513
201R:R:Y172 10.09615
202R:R:R186 5.3775406
203R:R:V187 4.045406
204R:R:F191 7.626519
205R:R:W195 6.6825416
206R:R:M198 6.622517
207R:R:C201 3.85407
208R:R:Y202 6.97833619
209R:R:S214 7.365413
210R:R:Y238 5.9325418
211R:R:Y241 6.32667617
212R:R:H242 6.32518
213R:R:L245 7.1875416
214R:R:R248 8.44405
215R:R:F252 2.8925404
216R:R:F272 6.29514
217R:R:Y275 8.89416
218R:R:H276 10.3183615
219R:R:T283 3.695417
220R:R:N285 7.1525409
221R:R:P290 3.8375419
222R:R:Y293 6.45571719
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F219 A:A:H41 75.62354.53YesYes186
2A:A:F212 A:A:F219 76.491416.08YesYes198
3A:A:F212 A:A:M221 38.7513.73YesYes198
4A:A:I245 A:A:M221 38.56372.92YesYes178
5A:A:F290 A:A:I245 38.92942.51YesYes197
6A:A:F290 A:A:R374 50.3583.21YesYes194
7A:A:E370 A:A:R374 61.80116.98NoYes044
8A:A:D368 A:A:E370 1005.2NoNo094
9A:A:C365 A:A:D368 99.96326.22NoNo089
10A:A:C365 A:A:D295 99.92633.11NoNo089
11A:A:D295 A:A:L296 99.88936.79NoNo096
12A:A:L296 A:A:S251 99.36186.01NoNo069
13A:A:L297 A:A:S251 96.81663YesNo089
14A:A:L297 A:A:Q294 94.073.99YesYes586
15A:A:F363 A:A:Q294 93.53235.86YesYes556
16A:A:F363 A:A:L291 92.32574.87YesYes558
17A:A:L291 A:A:V248 91.1182.98YesYes587
18A:A:F246 A:A:V248 92.08842.62NoYes097
19A:A:D272 A:A:F246 94.80132.39NoNo089
20A:A:D272 A:A:R231 94.70213.57NoYes089
21A:A:R231 A:A:W234 29.37179YesYes299
22A:A:F238 A:A:W234 13.4454.01YesYes299
23A:A:A372 A:A:F212 38.16842.77NoYes089
24A:A:A372 A:A:H64 38.18364.39NoNo088
25A:A:H64 A:A:Y63 38.20126.53NoNo089
26A:A:T369 A:A:Y63 38.24368.74NoNo099
27A:A:E370 A:A:T369 38.26664.23NoNo049
28A:A:H41 A:A:I383 75.53073.98YesYes168
29B:B:C148 B:B:T102 10.08083.38NoNo368
30B:B:L190 B:B:S160 17.59114.5YesNo056
31B:B:S147 B:B:S160 22.82654.89NoNo096
32B:B:S147 B:B:Y145 22.99792.54NoYes098
33A:A:N279 A:A:W281 68.10283.39NoYes285
34A:A:W281 B:B:W332 13.2183.75YesYes259
35B:B:W332 B:B:Y59 11.344712.54YesYes298
36A:A:F290 A:A:I288 11.0463.77YesYes199
37A:A:H362 A:A:I288 10.93472.65NoYes199
38A:A:H362 A:A:R374 10.974718.05NoYes194
39A:A:W281 B:B:D290 65.26147.82YesYes256
40A:A:L388 R:R:L209 19.32652.77YesNo088
41R:R:L209 R:R:R220 20.323.64NoNo086
42R:R:C215 R:R:R220 20.41154.18NoNo026
43R:R:C215 R:R:S212 20.50383.44NoNo025
44A:A:D381 R:R:S212 20.59654.42NoNo085
45A:A:D381 A:A:Y360 20.579712.64NoYes188
46A:A:I288 A:A:Y360 21.56982.42YesYes198
47A:A:H387 A:A:I383 75.23513.98YesYes188
48A:A:H387 A:A:Y391 75.35353.27YesYes184
49A:A:L388 A:A:L393 18.6492.77YesNo088
50A:A:Y391 R:R:E51 19.409110.1YesYes146
51A:A:Y391 R:R:L52 34.33713.52YesYes147
52A:A:Y391 R:R:D114 20.158314.94YesYes148
53R:R:V111 R:R:Y293 15.7522.52YesYes189
54R:R:L52 R:R:V111 15.77074.47YesYes178
55R:R:R115 R:R:Y293 31.32333.09YesYes199
56R:R:L52 R:R:R115 18.53282.43YesYes179
57A:A:L393 R:R:R115 18.4869.72NoYes089
58B:B:F278 B:B:L285 31.729.74YesYes276
59B:B:C233 B:B:F278 57.08344.19NoYes037
60B:B:C233 B:B:S191 56.81581.72NoNo038
61B:B:F234 B:B:S191 56.54813.96YesNo058
62B:B:F234 B:B:L255 42.23262.44YesYes056
63B:B:L255 B:B:Q220 19.73822.66YesYes667
64B:B:D258 B:B:Q220 12.789414.36YesYes677
65B:B:D258 B:B:R22 12.267111.91YesNo076
66B:B:I18 B:B:R22 11.71045.01YesNo076
67B:B:I18 G:G:L19 19.51211.43YesNo079
68B:B:A11 G:G:L19 11.1521.58NoNo059
69B:B:F222 B:B:L255 15.56712.44YesYes686
70B:B:D258 B:B:F222 12.85914.78YesYes678
71B:B:D258 G:G:R27 12.82478.34YesYes678
72B:B:I18 G:G:R27 17.5512.51YesYes078
73B:B:C271 B:B:D290 68.9353.11YesYes256
74B:B:C271 B:B:Y289 68.12844.03YesYes257
75B:B:W297 B:B:Y289 66.99996.75YesYes287
76B:B:W297 B:B:Y264 66.961414.47YesYes285
77B:B:F234 B:B:V200 10.558210.49YesYes056
78B:B:L252 B:B:Y264 30.23755.86NoYes075
79R:R:D289 R:R:Y293 43.719513.79NoYes099
80R:R:D289 R:R:N285 26.70286.73NoYes099
81R:R:N285 R:R:Y238 25.73619.3YesYes098
82R:R:H242 R:R:Y238 24.12133.27YesYes188
83R:R:H242 R:R:Y241 22.85433.27YesYes187
84R:R:Y241 R:R:Y275 16.212112.91YesYes176
85R:R:E51 R:R:Y55 19.15874.49YesYes167
86R:R:S138 R:R:Y55 36.35092.54NoYes177
87R:R:L66 R:R:T283 11.95392.95YesYes177
88R:R:T283 R:R:Y24 10.80994.99YesYes178
89R:R:D114 R:R:Y55 19.17974.6YesYes187
90R:R:F107 R:R:S138 27.2196.61YesNo177
91R:R:F107 R:R:L59 11.13152.44YesNo079
92R:R:D63 R:R:L59 27.21034.07YesNo099
93R:R:C286 R:R:D63 15.26959.34NoYes079
94R:R:D289 R:R:L59 16.749512.21NoNo099
95A:A:I235 A:A:N279 67.93874.25YesNo298
96A:A:W234 B:B:Y145 18.86595.79YesYes298
97B:B:F278 B:B:L252 30.10532.44YesNo077
98B:B:L285 B:B:Y264 32.66854.69YesYes265
99A:A:I235 A:A:R231 64.53713.76YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ZF6
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Xenopus tropicalis
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.98
Date 2025-02-26
D.O.I. doi.org/10.1016/j.cell.2024.12.001
Net Summary
Imin 2.39
Number of Linked Nodes 839
Number of Links 1132
Number of Hubs 222
Number of Links mediated by Hubs 786
Number of Communities 14
Number of Nodes involved in Communities 340
Number of Links involved in Communities 549
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 3004161
Length Of Smallest Path 3
Average Path Length 37.5489
Length of Longest Path 66
Minimum Path Strength 1.34
Average Path Strength 5.45152
Maximum Path Strength 21.72
Minimum Path Correlation 0.7
Average Path Correlation 0.989332
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 35.0563
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.7479
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ZF6_Chain_A
EIEKQLQKD KQVYRATHR LLLLGASGK STIVKQMRI HVVTSGIFE 
TKFQVDKVN FHMFDVGQR DERRKWIQC FNDVTAIIF VVSSYNRLQ 
EALNFKSIW NNRWLRTIS VILFLNKQD LLAEKVLAG KSKIEDYFP 
EFARYTTPE DATPEPGED PRVTRAKYF IRDEFLRIS TASGDGRHY 
CYPHFTCVD TENRRFNDC RDIIQRMHL RQYELLTLS ADKAAVERS 
KMDNYKADD DSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8ZF6_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8ZF6_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtA0A6I8PUB9
Sequence
>8ZF6_Chain_R
SGLDSVLPP SLYALVFTL GLPANLLAL WAAWLQVRK GRELGVYLL 
NLSLSDLLL ICALPPWTD YYLRRDVWG YGPGACRLF GFVFYTNLY 
VGAAFLSCV SADRYLAVA HPLRFPGAR PIRSAAAVS ALIWMLELA 
ANAPPLLGE AIHRDRYNH TFCYESYPL SGRGAALAN VGRVLAGFL 
LPWGVMMLC YAGLLRALR GSASCEQRE RRRVRRLAL GLPCVALLC 
YGPYHALLL LRSLVFLCA LEERLFPAY HASLALATL NCLADPALY 
CL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZF6.zip



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