Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E16 4.11404
2A:A:H41 3.552596
3A:A:L46 2.535408
4A:A:N50 7.60254109
5A:A:S51 2.8925109
6A:A:K53 4.6265109
7A:A:F212 5.54409
8A:A:V214 4.3725496
9A:A:F219 4.97167698
10A:A:M221 4.476508
11A:A:F222 9.7454187
12A:A:V224 4.67419
13A:A:Q227 4.334519
14A:A:R228 5.0575419
15A:A:K233 4.92419
16A:A:W234 4.59519
17A:A:F238 6.06833619
18A:A:F246 4.0225489
19A:A:V248 3.4625487
20A:A:D252 6.16754108
21A:A:R265 7.394109
22A:A:F273 4.47667689
23A:A:W277 6.58143786
24A:A:W281 11.374515
25A:A:L282 4.17254199
26A:A:I288 4.8675459
27A:A:L289 3.586589
28A:A:F290 4.684559
29A:A:F312 2.89167668
30A:A:Y318 6.755466
31A:A:P321 3.4725465
32A:A:E330 7.8375463
33A:A:D331 4.8475404
34A:A:K338 6.986565
35A:A:Y339 4.98563
36A:A:F340 11.7175467
37A:A:R342 4.775464
38A:A:F345 7.7375488
39A:A:R356 5.8485202
40A:A:Y360 5.25167658
41A:A:H362 7.1025459
42A:A:T364 5.5175459
43A:A:R374 6.526554
44A:A:F376 4.495698
45A:A:D381 4.165458
46A:A:I383 2.9375408
47A:A:Y391 5.97625874
48B:B:I37 5.0345132
49B:B:V40 6.0954133
50B:B:M45 3.084114
51B:B:R48 7407
52B:B:R49 4.9025427
53B:B:H54 6.324529
54B:B:K57 7.92419
55B:B:Y59 4.7225418
56B:B:M61 2.9725426
57B:B:W63 5.02571727
58B:B:Q75 6.695419
59B:B:D76 5.8845179
60B:B:W82 9.022529
61B:B:D83 7.195428
62B:B:Y85 9.5325424
63B:B:T86 6.14426
64B:B:K89 6.13667629
65B:B:I93 3.3175407
66B:B:L95 3.21754148
67B:B:W99 8.392509
68B:B:M101 4.3275419
69B:B:Y105 5.148506
70B:B:S108 4.3075406
71B:B:Y111 5.245404
72B:B:C114 2.8625148
73B:B:G115 1.9409
74B:B:L117 3.7325419
75B:B:C121 2.9475408
76B:B:Y124 4.5265146
77B:B:L126 3.455405
78B:B:L139 4.6925409
79B:B:H142 5.885619
80B:B:Y145 4.19333918
81B:B:L146 3.9325417
82B:B:R150 5.9275446
83B:B:F151 3.75509
84B:B:L152 3.928503
85B:B:S160 2.8225446
86B:B:S161 6.72419
87B:B:D163 6.368519
88B:B:C166 2.7625448
89B:B:W169 7.592518
90B:B:F180 6.136547
91B:B:H183 6.48714749
92B:B:V187 4.26449
93B:B:F199 5.716549
94B:B:S201 4.1775449
95B:B:C204 4.8475417
96B:B:D205 5.81449
97B:B:S207 4.1025445
98B:B:K209 9.5775446
99B:B:W211 6.85167648
100B:B:Q220 4.518517
101B:B:F222 5.914518
102B:B:H225 6.25125819
103B:B:D228 7.5275419
104B:B:I232 3.842518
105B:B:F235 7.844516
106B:B:N237 6.85405
107B:B:F241 6.26616
108B:B:T243 4.446518
109B:B:G244 2.2975415
110B:B:S245 6.9925419
111B:B:D247 7.13419
112B:B:T249 5.0225416
113B:B:C250 3.9418
114B:B:R251 10.54518
115B:B:F253 5.08833616
116B:B:L255 3.185416
117B:B:R256 6.6625409
118B:B:D258 7.89417
119B:B:M262 5.5625414
120B:B:Y264 4.995615
121B:B:I269 3.5375414
122B:B:C271 3.83415
123B:B:I273 5.68416
124B:B:T274 3.3475418
125B:B:V276 2.1625416
126B:B:F278 4.625617
127B:B:G282 2.6775419
128B:B:R283 8.8425139
129B:B:G288 2.3875417
130B:B:Y289 6.37714717
131B:B:D290 6.45416
132B:B:N295 8.725416
133B:B:W297 6.105418
134B:B:R304 5.82415
135B:B:H311 7.295119
136B:B:R314 9.29667618
137B:B:L318 3.262506
138B:B:G319 2.4625425
139B:B:T321 5.925427
140B:B:W332 7.46833619
141B:B:D333 8.48254119
142B:B:K337 6.68254116
143B:B:I338 3.6825425
144B:B:W339 6.4125119
145G:G:I9 6.14402
146G:G:D48 5.548509
147G:G:P49 3.4325407
148G:G:V54 2.79406
149G:G:N59 7.21529
150G:G:F61 4.28125828
151R:R:V11 5.13533
152R:R:S13 5.2725435
153R:R:V15 2.91434
154R:R:Y24 4.49509
155R:R:N35 7.034259
156R:R:N50 4.5375477
157R:R:L52 4.484578
158R:R:Y55 4.105407
159R:R:L56 2.934578
160R:R:D63 4.9225409
161R:R:Y66 6.34507
162R:R:L70 4.9975408
163R:R:W73 6.755167
164R:R:V74 1.565407
165R:R:F77 5.4875405
166R:R:F97 8.258507
167R:R:F107 5.5765158
168R:R:D114 4.935478
169R:R:F125 4.065406
170R:R:R130 5.3575406
171R:R:W142 5.25254159
172R:R:E157 7.53254165
173R:R:D161 7.885432
174R:R:Y163 6.2325433
175R:R:F167 9.2375431
176R:R:W177 6.654501
177R:R:Y184 3.284263
178R:R:R185 6.4785265
179R:R:F190 8.5075438
180R:R:P193 4.5409
181R:R:W194 6.11406
182R:R:Y201 4.384297278
183R:R:S213 4.36453
184R:R:T214 4.4965123
185R:R:E218 8.74254125
186R:R:L229 3.39508
187R:R:F237 4.8525838
188R:R:Y240 8.15167636
189R:R:H241 7.366538
190R:R:R247 9.6125404
191R:R:Y251 5.0354293
192R:R:F260 7.1125401
193R:R:E261 4.4025434
194R:R:F265 6.28667634
195R:R:Y268 9.098535
196R:R:H269 8.885435
197R:R:L277 2.79254245
198R:R:Y286 3.708579
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F238 B:B:W99 34.53098.02YesYes099
2A:A:F238 A:A:L44 10017.05YesNo099
3A:A:L44 A:A:L46 99.88734.15NoYes098
4A:A:G47 A:A:L46 98.98211.71NoYes098
5A:A:G47 A:A:K53 80.91881.74NoYes1099
6A:A:K53 A:A:L45 83.55544.23YesNo098
7A:A:L45 A:A:M221 83.43017.07NoYes088
8A:A:F212 A:A:M221 68.51114.98YesYes098
9A:A:F212 A:A:F219 66.922411.79YesYes098
10A:A:F219 A:A:H41 64.37055.66YesYes986
11A:A:H41 A:A:I383 64.37252.65YesYes068
12A:A:I383 A:A:N387 64.02064.25YesNo088
13A:A:N387 A:A:Y391 63.57493.49NoYes784
14A:A:I245 A:A:M221 14.1982.92NoYes078
15A:A:G47 A:A:S51 17.94981.86NoYes1099
16A:A:N50 A:A:S51 20.61232.98YesYes1099
17A:A:D249 A:A:N50 19.605916.16NoYes1089
18A:A:F238 A:A:W234 10.54592YesYes199
19A:A:W281 B:B:W332 40.28272.81YesYes159
20B:B:R314 B:B:W332 42.059713YesYes189
21A:A:C237 A:A:F238 56.2372.79NoYes189
22A:A:C237 B:B:Q75 27.23873.05NoYes189
23B:B:Q75 B:B:W99 28.62666.57YesYes099
24A:A:C237 B:B:Y59 29.05212.69NoYes188
25B:B:K57 B:B:Y59 35.36342.39YesYes198
26B:B:K57 B:B:W332 90.886612.76YesYes199
27B:B:K57 B:B:Q75 55.81668.14YesYes199
28A:A:F290 A:A:I245 13.85032.51YesNo097
29A:A:D249 A:A:K293 19.46156.91NoNo089
30A:A:K293 A:A:L296 19.29592.82NoNo096
31A:A:L296 A:A:S251 18.30067.51NoNo069
32A:A:K300 A:A:S251 18.13441.53NoNo099
33A:A:K300 A:A:Y253 17.968110.75NoNo098
34A:A:F312 A:A:F340 15.41775.36YesYes687
35A:A:F340 A:A:Y318 13.713411.35YesYes676
36A:A:D343 A:A:Y318 11.66298.05NoYes636
37A:A:D343 A:A:R342 11.32593.57NoYes634
38A:A:R342 A:A:Y339 10.30035.14YesYes643
39A:A:D378 A:A:Y360 12.50629.2NoYes578
40A:A:Y391 R:R:L52 52.70517.03YesYes748
41R:R:L52 R:R:L56 52.60592.77YesYes788
42R:R:L56 R:R:Y286 52.15082.34YesYes789
43B:B:D258 B:B:F222 13.64535.97YesYes178
44B:B:D258 B:B:R22 11.844911.91YesNo076
45B:B:I18 B:B:R22 11.39055.01NoNo076
46B:B:I18 G:G:A23 10.48033.25NoNo2178
47G:G:A23 G:G:K20 10.02661.61NoNo086
48B:B:F235 B:B:F278 11.36689.65YesYes167
49B:B:F241 B:B:L255 10.51994.87YesYes166
50B:B:L210 B:B:L255 12.21362.77NoYes156
51B:B:L198 B:B:L210 13.04562.77NoNo035
52B:B:I273 B:B:Y289 28.404910.88YesYes167
53B:B:G244 B:B:I273 53.31553.53YesYes156
54B:B:G244 B:B:S245 50.82471.86YesYes159
55B:B:H225 B:B:S245 39.34513.95YesYes199
56B:B:F253 B:B:H225 27.42892.26YesYes169
57B:B:F241 B:B:T243 10.46112.59YesYes168
58B:B:W297 B:B:Y289 20.14195.79YesYes187
59B:B:W297 B:B:Y264 19.72987.72YesYes185
60B:B:C271 B:B:D290 78.93043.11YesYes156
61B:B:C271 B:B:G272 28.23791.96YesNo054
62R:R:L108 R:R:Y286 46.51387.03NoYes089
63R:R:D282 R:R:L108 46.22312.71NoNo098
64R:R:D282 R:R:N278 43.492614.81NoNo099
65R:R:F237 R:R:N278 43.18229.67YesNo389
66R:R:F237 R:R:H241 22.41432.26YesYes388
67R:R:H241 R:R:Y240 22.62125.44YesYes386
68R:R:Y240 R:R:Y268 24.87668.94YesYes365
69R:R:F237 R:R:T275 21.34495.19YesNo088
70R:R:T275 R:R:Y240 21.18233.75NoYes086
71R:R:H269 R:R:Y268 17.41912.18YesYes355
72R:R:L272 R:R:Y240 17.10716.41NoYes056
73R:R:L272 R:R:Y98 16.75473.52NoNo055
74R:R:F97 R:R:Y98 16.09088.25YesNo075
75A:A:W281 B:B:D290 39.82486.7YesYes156
76B:B:D290 B:B:R314 39.325313.1YesYes168
77B:B:F222 B:B:F253 21.30844.29YesYes186
78B:B:C271 B:B:Y289 50.02454.03YesYes157
79B:B:G272 B:B:I273 28.02171.76NoYes046
80B:B:D212 B:B:L198 10.81484.07NoNo093
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9JFX
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.87
Date 2025-04-23
D.O.I. doi.org/10.1038/s41422-025-01092-w
Net Summary
Imin 1.71
Number of Linked Nodes 852
Number of Links 1097
Number of Hubs 198
Number of Links mediated by Hubs 709
Number of Communities 29
Number of Nodes involved in Communities 290
Number of Links involved in Communities 425
Path Summary
Number Of Nodes in MetaPath 81
Number Of Links MetaPath 80
Number of Shortest Paths 2888710
Length Of Smallest Path 3
Average Path Length 31.4436
Length of Longest Path 62
Minimum Path Strength 1.11
Average Path Strength 5.69882
Maximum Path Strength 21.49
Minimum Path Correlation 0.7
Average Path Correlation 0.989968
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 42.207
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 62.5478
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • Ras protein signal transduction   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • ectodermal placode formation   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell-cell adhesion   • coagulation   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9JFX_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGASGKST 
IVKQMRILS GIFETKFQV DKVNFHMFD VGGQRDERR KWIQCFNDV 
TAIIFVVSS YNRLQEALN LFKSIWNNR WLRTISVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD 
EFLRISTAS GDGRHYCYP HFTCAVDTE NRRFNDCDI IMLRYLDND 
DAIKLQNEN V


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JFX_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JFX_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JFX_Chain_R
GCHVDSRVD HLFPPSLYI VIGVGLPTN CLALWAAYR QVQQRNELG 
YLMLSIADL YICTLPWVD YFHHDNWIH GPGSCKLFF IFYTNIYIS 
IAFLCCIVD RYLAVAHPL RFRLRRVTV AVSSVVWAT ELGANSAPL 
FHDELFRDR YNHTCFEKF PMEGWVAWM NLYRFVGFF PWAMLSYRL 
RVRGSVSTE RQEKAKIKL ALSLAIVLV CFAPYHVLL SRSAIYGRP 
WDCGFEERV FSAYHSSAF TSLNCVDPI YLVNEGARS DAKALHNLF 
VNLLLGSAK AFVLLLGIA RILLLALCV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JFX.zip



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