psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C258	R:R:C9	7.28	Yes	No	1	8	8
2	R:R:C9	R:R:E261	4.56	No	Yes	1	8	4
3	R:R:C9	R:R:E262	7.6	No	Yes	1	8	3
4	R:R:H10	R:R:Y163	22.87	No	No	0	3	3
5	R:R:E262	R:R:H10	6.15	Yes	No	0	3	3
6	R:R:H165	R:R:V11	6.92	Yes	No	1	1	3
7	R:R:F172	R:R:V11	7.87	Yes	No	1	5	3
8	R:R:F265	R:R:V11	14.42	Yes	No	1	4	3
9	R:R:D16	R:R:S13	4.42	Yes	No	0	5	5
10	R:R:H80	R:R:S13	6.97	No	No	0	4	5
11	R:R:D16	R:R:F265	7.17	Yes	Yes	1	5	4
12	R:R:D16	R:R:H269	7.56	Yes	Yes	1	5	5
13	R:R:H17	R:R:H80	27.47	No	No	0	5	4
14	R:R:F19	R:R:P20	7.22	No	No	0	5	5
15	R:R:F19	R:R:S270	7.93	No	No	0	5	5
16	R:R:A273	R:R:F19	4.16	No	No	0	5	5
17	R:R:P20	R:R:P21	5.84	No	Yes	1	5	7
18	R:R:F77	R:R:P20	4.33	Yes	No	1	5	5
19	R:R:P21	R:R:V74	5.3	Yes	No	1	7	7
20	R:R:F77	R:R:P21	4.33	Yes	Yes	1	5	7
21	R:R:L78	R:R:P21	6.57	No	Yes	1	5	7
22	R:R:L23	R:R:V27	4.47	No	No	0	5	7
23	R:R:A273	R:R:L23	6.3	No	No	0	5	5
24	R:R:L23	R:R:L277	8.3	No	No	0	5	5
25	R:R:L70	R:R:Y24	10.55	No	Yes	0	8	9
26	R:R:F77	R:R:Y24	8.25	Yes	Yes	0	5	9
27	R:R:F97	R:R:Y24	8.25	Yes	Yes	0	7	9
28	R:R:S276	R:R:Y24	6.36	No	Yes	0	7	9
29	R:R:F26	R:R:V30	5.24	No	No	0	4	6
30	R:R:S276	R:R:V27	4.85	No	No	0	7	7
31	R:R:I28	R:R:I67	4.42	Yes	No	0	7	6
32	R:R:I28	R:R:L70	7.14	Yes	No	0	7	8
33	R:R:I67	R:R:L32	4.28	No	No	0	6	6
34	R:R:P283	R:R:T34	6.99	No	No	0	9	7
35	R:R:D63	R:R:N35	6.73	Yes	Yes	0	9	9
36	R:R:L64	R:R:N35	4.12	No	Yes	0	8	9
37	R:R:N35	R:R:P283	13.03	Yes	No	0	9	9
38	R:R:L301	R:R:L37	6.92	No	No	0	6	7
39	R:R:L39	R:R:M57	5.65	No	No	0	7	5
40	R:R:R44	R:R:W40	9	No	No	0	4	4
41	R:R:Q47	R:R:Y43	7.89	No	No	0	6	4
42	R:R:M57	R:R:Y43	4.79	No	No	0	5	4
43	R:R:Q47	R:R:R44	8.18	No	No	0	6	4
44	R:R:D296	R:R:R44	5.96	No	No	0	4	4
45	R:R:Q45	R:R:Q48	7.68	No	No	0	5	7
46	R:R:N50	R:R:Q45	7.92	No	No	0	7	5
47	R:R:R49	R:R:V131	7.85	No	Yes	0	6	3
48	R:R:L52	R:R:N50	4.12	No	No	0	8	7
49	R:R:E51	R:R:Y55	5.61	Yes	Yes	2	7	7
50	R:R:D114	R:R:E51	11.69	No	Yes	2	8	7
51	R:R:A134	R:R:E51	6.03	No	Yes	2	8	7
52	R:R:L52	R:R:L56	4.15	No	No	0	8	8
53	R:R:I111	R:R:L52	4.28	Yes	No	0	9	8
54	R:R:A134	R:R:V54	5.09	No	Yes	2	8	7
55	R:R:C110	R:R:Y55	8.06	No	Yes	0	7	7
56	R:R:D114	R:R:Y55	6.9	No	Yes	2	8	7
57	R:R:A134	R:R:Y55	4	No	Yes	2	8	7
58	R:R:V137	R:R:Y55	5.05	No	Yes	0	5	7
59	R:R:F107	R:R:N58	14.5	Yes	No	4	8	9
60	R:R:N58	R:R:S138	8.94	No	No	4	9	7
61	R:R:N58	R:R:W142	4.52	No	Yes	4	9	9
62	R:R:L108	R:R:L59	5.54	Yes	No	3	8	9
63	R:R:D282	R:R:L59	6.79	Yes	No	3	9	9
64	R:R:D63	R:R:S104	5.89	Yes	No	0	9	9
65	R:R:C279	R:R:D63	6.22	No	Yes	0	9	9
66	R:R:D282	R:R:D63	6.65	Yes	Yes	0	9	9
67	R:R:L70	R:R:Y66	8.21	No	Yes	0	8	7
68	R:R:F97	R:R:Y66	13.41	Yes	Yes	0	7	7
69	R:R:N100	R:R:Y66	4.65	Yes	Yes	0	8	7
70	R:R:S276	R:R:Y66	7.63	No	Yes	0	7	7
71	R:R:C279	R:R:Y66	9.41	No	Yes	0	9	7
72	R:R:F93	R:R:T69	6.49	No	No	0	6	7
73	R:R:I96	R:R:T69	10.64	No	No	0	5	7
74	R:R:F93	R:R:L72	12.18	No	No	0	6	7
75	R:R:W73	R:R:Y76	7.72	No	Yes	0	7	6
76	R:R:G94	R:R:W73	4.22	No	No	0	6	7
77	R:R:F97	R:R:W73	20.04	Yes	No	0	7	7
78	R:R:L78	R:R:V74	4.47	No	No	1	5	7
79	R:R:F77	R:R:Y76	10.32	Yes	Yes	1	5	6
80	R:R:D81	R:R:Y76	14.94	Yes	Yes	1	4	6
81	R:R:W83	R:R:Y76	4.82	Yes	Yes	1	9	6
82	R:R:D81	R:R:F77	5.97	Yes	Yes	1	4	5
83	R:R:F77	R:R:H269	6.79	Yes	Yes	1	5	5
84	R:R:H79	R:R:N82	5.1	No	No	6	4	5
85	R:R:H79	R:R:I84	9.28	No	No	6	4	3
86	R:R:D81	R:R:F167	5.97	Yes	Yes	1	4	4
87	R:R:D81	R:R:F265	4.78	Yes	Yes	1	4	4
88	R:R:D81	R:R:H269	7.56	Yes	Yes	1	4	5
89	R:R:I84	R:R:N82	11.33	No	No	6	3	5
90	R:R:N82	R:R:T166	7.31	No	No	0	5	3
91	R:R:H85	R:R:W83	9.52	No	Yes	1	7	9
92	R:R:S89	R:R:W83	7.41	No	Yes	1	6	9
93	R:R:C90	R:R:W83	9.14	No	Yes	1	9	9
94	R:R:L158	R:R:W83	5.69	No	Yes	0	5	9
95	R:R:C168	R:R:W83	13.06	No	Yes	1	9	9
96	R:R:H85	R:R:S89	5.58	No	No	1	7	6
97	R:R:G86	R:R:P87	4.06	No	No	0	8	3
98	R:R:L158	R:R:P87	6.57	No	No	0	5	3
99	R:R:C168	R:R:C90	7.28	No	No	1	9	9
100	R:R:E157	R:R:K91	5.4	No	No	0	5	6
101	R:R:F93	R:R:L92	6.09	No	No	0	6	5
102	R:R:F169	R:R:G94	6.02	No	No	0	4	6
103	R:R:F95	R:R:T99	11.67	No	Yes	0	6	5
104	R:R:F95	R:R:L153	14.61	No	No	0	6	4
105	R:R:I96	R:R:N100	5.66	No	Yes	0	5	8
106	R:R:F97	R:R:Y98	7.22	Yes	No	0	7	5
107	R:R:R185	R:R:Y98	4.12	Yes	No	0	5	5
108	R:R:N100	R:R:T99	4.39	Yes	Yes	0	8	5
109	R:R:L146	R:R:T99	4.42	No	Yes	0	3	5
110	R:R:N149	R:R:T99	5.85	No	Yes	0	7	5
111	R:R:I101	R:R:Y102	13.3	No	No	0	8	7
112	R:R:R185	R:R:Y102	13.38	Yes	No	0	5	7
113	R:R:H241	R:R:Y102	6.53	Yes	No	0	8	7
114	R:R:I103	R:R:W142	12.92	No	Yes	0	7	9
115	R:R:E145	R:R:I103	4.1	Yes	No	0	7	7
116	R:R:I105	R:R:P193	6.77	No	No	0	8	9
117	R:R:A106	R:R:E145	4.53	No	Yes	0	6	7
118	R:R:F107	R:R:S138	5.28	Yes	No	4	8	7
119	R:R:F107	R:R:V141	7.87	Yes	No	0	8	7
120	R:R:F107	R:R:W142	10.02	Yes	Yes	4	8	9
121	R:R:D282	R:R:L108	9.5	Yes	Yes	3	9	8
122	R:R:L108	R:R:Y286	9.38	Yes	No	0	8	9
123	R:R:C109	R:R:L196	4.76	No	No	0	8	6
124	R:R:I111	R:R:R115	5.01	Yes	No	0	9	9
125	R:R:I111	R:R:Y286	4.84	Yes	No	0	9	9
126	R:R:M197	R:R:S112	9.2	No	No	0	7	9
127	R:R:S112	R:R:S200	4.89	No	No	0	9	8
128	R:R:S112	R:R:Y201	8.9	No	Yes	0	9	8
129	R:R:R115	R:R:Y201	7.2	No	Yes	0	9	8
130	R:R:A120	R:R:Y116	8.01	No	Yes	7	7	8
131	R:R:H121	R:R:Y116	9.8	Yes	Yes	7	6	8
132	R:R:A120	R:R:H121	4.39	No	Yes	7	7	6
133	R:R:F125	R:R:H121	5.66	No	Yes	0	6	6
134	R:R:F125	R:R:R124	5.34	No	No	0	6	4
135	R:R:E145	R:R:N149	3.94	Yes	No	0	7	7
136	R:R:A148	R:R:Y184	4	No	No	0	5	3
137	R:R:M181	R:R:N149	4.21	No	No	0	4	7
138	R:R:F169	R:R:P152	5.78	No	No	0	4	3
139	R:R:P152	R:R:W177	8.11	No	Yes	0	3	1
140	R:R:H155	R:R:W177	37.03	No	Yes	0	4	1
141	R:R:D156	R:R:F159	13.14	No	No	0	5	2
142	R:R:E157	R:R:F169	27.98	No	No	0	5	4
143	R:R:L158	R:R:T166	4.42	No	No	0	5	3
144	R:R:F159	R:R:K171	9.93	No	No	0	2	3
145	R:R:R160	R:R:T166	14.23	No	No	0	1	3
146	R:R:D161	R:R:Y163	9.2	No	No	1	2	3
147	R:R:D161	R:R:H165	11.35	No	Yes	1	2	1
148	R:R:D161	R:R:F167	11.94	No	Yes	1	2	4
149	R:R:H165	R:R:Y163	6.53	Yes	No	1	1	3
150	R:R:F167	R:R:H165	9.05	Yes	Yes	1	4	1
151	R:R:F167	R:R:F172	11.79	Yes	Yes	1	4	5
152	R:R:E170	R:R:F172	13.99	No	Yes	1	4	5
153	R:R:E170	R:R:Y268	8.98	No	Yes	1	4	5
154	R:R:E170	R:R:H269	9.85	No	Yes	1	4	5
155	R:R:E175	R:R:K171	12.15	No	No	0	2	3
156	R:R:E261	R:R:F172	16.32	Yes	Yes	1	4	5
157	R:R:F172	R:R:F265	6.43	Yes	Yes	1	5	4
158	R:R:C258	R:R:P173	5.65	Yes	No	1	8	4
159	R:R:E261	R:R:P173	4.72	Yes	No	1	4	4
160	R:R:M174	R:R:V178	4.56	No	No	0	1	2
161	R:R:M174	R:R:R247	6.2	No	Yes	0	1	4
162	R:R:M174	R:R:Y251	8.38	No	Yes	0	1	3
163	R:R:E175	R:R:W177	8.72	No	Yes	0	2	1
164	R:R:G176	R:R:Y251	4.35	No	Yes	0	4	3
165	R:R:N182	R:R:V178	4.43	Yes	No	0	5	2
166	R:R:A179	R:R:L252	4.73	No	No	0	1	1
167	R:R:L252	R:R:W180	9.11	No	No	0	1	3
168	R:R:M181	R:R:R185	4.96	No	Yes	0	4	5
169	R:R:N182	R:R:R185	4.82	Yes	Yes	0	5	5
170	R:R:L244	R:R:N182	13.73	No	Yes	0	5	5
171	R:R:N182	R:R:S248	5.96	Yes	No	0	5	5
172	R:R:V188	R:R:Y184	10.09	No	No	0	4	3
173	R:R:H241	R:R:V186	8.3	Yes	No	0	8	5
174	R:R:F190	R:R:F237	6.43	No	Yes	0	8	8
175	R:R:F190	R:R:H241	19.23	No	Yes	0	8	8
176	R:R:F192	R:R:L196	7.31	No	No	0	5	6
177	R:R:I230	R:R:W194	4.7	No	Yes	0	7	6
178	R:R:V233	R:R:W194	4.9	No	Yes	0	9	6
179	R:R:L234	R:R:W194	21.64	No	Yes	0	6	6
180	R:R:I204	R:R:Y201	4.84	No	Yes	0	8	8
181	R:R:A226	R:R:Y201	4	No	Yes	0	7	8
182	R:R:L229	R:R:Y201	5.86	No	Yes	0	8	8
183	R:R:R202	R:R:R206	5.33	No	No	0	3	3
184	R:R:G203	R:R:R206	4.5	No	No	0	4	3
185	R:R:K223	R:R:L205	5.64	No	No	0	6	5
186	R:R:K219	R:R:V208	4.55	No	No	0	6	8
187	R:R:I222	R:R:V208	4.61	No	No	0	7	8
188	R:R:S211	R:R:T214	6.4	No	No	0	5	3
189	R:R:E218	R:R:T214	7.06	No	No	0	5	3
190	R:R:K219	R:R:T214	4.5	No	No	0	6	3
191	R:R:K223	R:R:L227	8.46	No	No	0	6	5
192	R:R:L225	R:R:V289	5.96	No	No	0	8	6
193	R:R:L285	R:R:S228	6.01	Yes	No	0	8	6
194	R:R:L229	R:R:L285	4.15	No	Yes	0	8	8
195	R:R:L229	R:R:Y286	11.72	No	No	0	8	9
196	R:R:I232	R:R:L285	4.28	No	Yes	0	7	8
197	R:R:C236	R:R:F237	5.59	No	Yes	3	8	8
198	R:R:C236	R:R:N278	6.3	No	No	3	8	9
199	R:R:F237	R:R:T275	5.19	Yes	No	0	8	8
200	R:R:F237	R:R:N278	12.08	Yes	No	3	8	9
201	R:R:H241	R:R:Y240	8.71	Yes	Yes	0	8	6
202	R:R:L244	R:R:Y240	9.38	No	Yes	0	5	6
203	R:R:Y240	R:R:Y268	7.94	Yes	Yes	1	6	5
204	R:R:L272	R:R:Y240	10.55	No	Yes	1	5	6
205	R:R:L243	R:R:V264	4.47	No	Yes	0	4	4
206	R:R:L243	R:R:S271	4.5	No	No	0	4	7
207	R:R:F260	R:R:S246	3.96	Yes	No	0	1	4
208	R:R:F260	R:R:R247	4.28	Yes	Yes	0	1	4
209	R:R:E261	R:R:R247	4.65	Yes	Yes	0	4	4
210	R:R:R247	R:R:Y268	14.4	Yes	Yes	0	4	5
211	R:R:F260	R:R:I250	10.05	Yes	No	0	1	1
212	R:R:P255	R:R:Y251	9.74	No	Yes	0	2	3
213	R:R:R254	R:R:W256	19.99	No	No	0	2	3
214	R:R:D257	R:R:R254	16.68	No	No	0	5	2
215	R:R:C258	R:R:E261	6.08	Yes	Yes	1	8	4
216	R:R:C258	R:R:E262	7.6	Yes	Yes	1	8	3
217	R:R:F260	R:R:V264	14.42	Yes	Yes	0	1	4
218	R:R:F265	R:R:H269	12.44	Yes	Yes	1	4	5
219	R:R:H269	R:R:Y268	10.89	Yes	Yes	1	5	5
220	R:R:L272	R:R:Y268	4.69	No	Yes	1	5	5
221	R:R:F274	R:R:L277	8.53	No	No	0	7	5
222	R:R:D282	R:R:N278	10.77	Yes	No	3	9	9
223	R:R:C287	R:R:L288	4.76	Yes	No	0	7	7
224	R:R:E291	R:R:R294	4.65	No	No	0	5	8
225	R:R:K299	R:R:S295	4.59	No	No	0	5	4
226	R:R:H302	R:R:R306	6.77	No	No	0	5	7
227	R:R:A300	R:R:W40	3.89	No	No	0	3	4
228	R:R:R130	R:R:T133	3.88	No	No	0	6	3
229	R:R:H17	R:R:L18	3.86	No	No	0	5	4
230	R:R:D75	R:R:H79	3.78	No	No	0	4	4
231	R:R:C109	R:R:P193	3.77	No	No	0	8	9
232	R:R:G147	R:R:S150	3.71	No	No	0	4	4
233	R:R:G189	R:R:V188	3.68	No	No	0	6	4
234	R:R:F190	R:R:L191	3.65	No	No	0	8	4
235	R:R:L288	R:R:R294	3.64	No	No	0	7	8
236	R:R:I111	R:R:Y55	3.63	Yes	Yes	0	9	7
237	R:R:N303	R:R:R306	3.62	No	No	0	3	7
238	R:R:A38	R:R:C287	3.61	No	Yes	0	9	7
239	R:R:M181	R:R:Y184	3.59	No	No	0	4	3
240	R:R:E51	R:R:R129	3.49	Yes	No	0	7	7
241	R:R:G53	R:R:L56	3.42	No	No	0	7	8
242	R:R:L198	R:R:W194	3.42	No	Yes	0	5	6
243	R:R:L123	R:R:P122	3.28	No	No	0	6	7
244	R:R:E262	R:R:G259	3.27	Yes	No	0	3	2
245	R:R:S200	R:R:V113	3.23	No	No	0	8	6
246	R:R:V280	R:R:V30	3.21	No	No	5	8	6
247	R:R:V46	R:R:V54	3.21	No	Yes	2	6	7
248	R:R:V135	R:R:V54	3.21	No	Yes	2	4	7
249	R:R:A226	R:R:L205	3.15	No	No	0	7	5
250	R:R:A238	R:R:L234	3.15	No	No	0	5	6
251	R:R:I25	R:R:V74	3.07	No	No	0	4	7
252	R:R:L39	R:R:S60	3	No	No	0	7	8
253	R:R:N35	R:R:S60	2.98	Yes	No	0	9	8
254	R:R:L245	R:R:V186	2.98	No	No	0	6	5
255	R:R:L285	R:R:V289	2.98	Yes	No	0	8	6
256	R:R:D16	R:R:S266	2.94	Yes	No	0	5	2
257	R:R:G203	R:R:Y116	2.9	No	Yes	0	4	8
258	R:R:I105	R:R:L108	2.85	No	Yes	0	8	8
259	R:R:E51	R:R:T133	2.82	Yes	No	0	7	3
260	R:R:E145	R:R:T144	2.82	Yes	No	0	7	5
261	R:R:L117	R:R:L128	2.77	No	No	0	6	3
262	R:R:A118	R:R:R129	2.77	No	No	0	8	7
263	R:R:L183	R:R:L252	2.77	No	No	0	4	1
264	R:R:D296	R:R:K299	2.77	No	No	0	4	5
265	R:R:L65	R:R:N100	2.75	No	Yes	0	7	8
266	R:R:P255	R:R:W256	2.7	No	No	0	2	3
267	R:R:A179	R:R:Y251	2.67	No	Yes	0	1	3
268	R:R:F95	R:R:S150	2.64	No	No	0	6	4
269	R:R:F274	R:R:V235	2.62	No	No	0	7	5
270	R:R:A62	R:R:W142	2.59	No	Yes	0	8	9
271	R:R:A151	R:R:W177	2.59	No	Yes	0	7	1
272	R:R:S200	R:R:Y116	2.54	No	Yes	0	8	8
273	R:R:E215	R:R:E218	2.54	No	No	0	3	5
274	R:R:K221	R:R:R224	2.48	No	No	0	7	6
275	R:R:F125	R:R:L117	2.44	No	No	0	6	6
276	R:R:F187	R:R:L191	2.44	No	No	0	5	4
277	R:R:F187	R:R:L245	2.44	No	No	0	5	6
278	R:R:I230	R:R:Y201	2.42	No	Yes	0	7	8
279	R:R:F307	R:R:N303	2.42	No	No	0	5	3
280	R:R:G8	R:R:P173	2.03	No	No	0	5	4
281	R:R:G31	R:R:P33	2.03	Yes	No	0	8	5
282	R:R:A42	R:R:G53	1.95	No	No	0	7	7
283	R:R:A38	R:R:P283	1.87	No	No	0	9	9
284	R:R:A238	R:R:P239	1.87	No	No	0	5	9
285	R:R:G292	R:R:S295	1.86	No	No	0	6	4
286	R:R:G31	R:R:V30	1.84	Yes	No	5	8	6
287	R:R:G31	R:R:V280	1.84	Yes	No	5	8	8
288	R:R:G31	R:R:T34	1.82	Yes	No	0	8	7
289	R:R:A41	R:R:C287	1.81	No	Yes	0	7	7
290	R:R:A293	R:R:C287	1.81	No	Yes	0	8	7
291	R:R:G29	R:R:I28	1.76	No	Yes	0	5	7
292	R:R:G88	R:R:K91	1.74	No	No	0	2	6
293	R:R:C287	R:R:V297	1.71	Yes	No	0	7	6
294	R:R:A309	R:R:S310	1.71	No	No	0	5	3
295	R:R:A207	R:R:V119	1.7	No	No	0	5	8
296	R:R:A267	R:R:V264	1.7	No	Yes	0	5	4
297	R:R:G292	R:R:N290	1.7	No	No	0	6	8
298	R:R:I28	R:R:P71	1.69	Yes	No	0	7	8
299	R:R:S211	R:R:S213	1.63	No	No	0	5	3
300	R:R:S266	R:R:V15	1.62	No	No	0	2	4
301	R:R:S139	R:R:V135	1.62	No	No	0	5	4
302	R:R:A281	R:R:I232	1.62	No	No	0	7	7
303	R:R:V131	R:R:V46	1.6	Yes	No	2	3	6
304	R:R:V131	R:R:V54	1.6	Yes	Yes	2	3	7
305	R:R:V131	R:R:V135	1.6	Yes	No	2	3	4
306	R:R:C36	R:R:L64	1.59	No	No	0	3	8
307	R:R:T144	R:R:V140	1.59	No	No	0	5	3
308	R:R:I204	R:R:V119	1.54	No	No	0	8	8
309	R:R:I204	R:R:V208	1.54	No	No	0	8	8
310	R:R:H121	R:R:P122	1.53	Yes	No	0	6	7
311	R:R:G210	R:R:R209	1.5	No	No	0	4	4
312	R:R:G253	R:R:R254	1.5	No	No	0	3	2
313	R:R:L243	R:R:V242	1.49	No	No	0	4	6
314	R:R:I61	R:R:M57	1.46	No	No	0	5	5
315	R:R:K299	R:R:N303	1.4	No	No	0	5	3
316	R:R:A220	R:R:R224	1.38	No	No	0	5	6
317	R:R:R14	R:R:V15	1.31	No	No	0	2	4
318	R:R:R263	R:R:V264	1.31	No	Yes	0	3	4
319	R:R:E215	R:R:Q217	1.27	No	No	0	3	4
320	R:R:K132	R:R:R130	1.24	No	No	0	4	6
321	R:R:F154	R:R:L153	1.22	No	No	0	4	4
322	R:R:F307	R:R:L304	1.22	No	No	0	5	4
323	R:R:L205	R:R:R209	1.21	No	No	0	5	4
324	R:R:L305	R:R:R306	1.21	No	No	0	3	7
325	R:R:E215	R:R:R216	1.16	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D16	5.5225	4	1	5
2	R:R:P21	5.51	4	1	7
3	R:R:Y24	8.3525	4	0	9
4	R:R:I28	3.7525	4	0	7
5	R:R:G31	1.8825	4	5	8
6	R:R:N35	6.715	4	0	9
7	R:R:E51	5.928	5	2	7
8	R:R:V54	3.2775	4	2	7
9	R:R:Y55	5.54167	6	2	7
10	R:R:D63	6.3725	4	0	9
11	R:R:Y66	8.662	5	0	7
12	R:R:Y76	9.45	4	1	6
13	R:R:F77	6.665	6	1	5
14	R:R:D81	7.844	5	1	4
15	R:R:W83	8.27333	6	1	9
16	R:R:F97	12.23	4	0	7
17	R:R:T99	6.5825	4	0	5
18	R:R:N100	4.3625	4	0	8
19	R:R:F107	9.4175	4	4	8
20	R:R:L108	6.8175	4	3	8
21	R:R:I111	4.44	4	0	9
22	R:R:Y116	5.8125	4	7	8
23	R:R:H121	5.345	4	7	6
24	R:R:V131	3.1625	4	2	3
25	R:R:W142	7.5125	4	4	9
26	R:R:E145	3.8475	4	0	7
27	R:R:H165	8.4625	4	1	1
28	R:R:F167	9.6875	4	1	4
29	R:R:F172	11.28	5	1	5
30	R:R:W177	14.1125	4	0	1
31	R:R:N182	7.235	4	0	5
32	R:R:R185	6.82	4	0	5
33	R:R:W194	8.665	4	0	6
34	R:R:Y201	5.53667	6	0	8
35	R:R:F237	7.3225	4	3	8
36	R:R:Y240	9.145	4	1	6
37	R:R:H241	10.6925	4	0	8
38	R:R:R247	7.3825	4	0	4
39	R:R:Y251	6.285	4	0	3
40	R:R:C258	6.6525	4	1	8
41	R:R:F260	8.1775	4	0	1
42	R:R:E261	7.266	5	1	4
43	R:R:E262	6.155	4	1	3
44	R:R:V264	5.475	4	0	4
45	R:R:F265	9.048	5	1	4
46	R:R:Y268	9.38	5	1	5
47	R:R:H269	9.18167	6	1	5
48	R:R:D282	8.4275	4	3	9
49	R:R:L285	4.355	4	0	8
50	R:R:C287	2.74	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C258	R:R:E261	11.6613	6.08	Yes	Yes	1	8	4
2	R:R:E261	R:R:F172	24.3571	16.32	Yes	Yes	1	4	5
3	R:R:F172	R:R:F265	13.3477	6.43	Yes	Yes	1	5	4
4	R:R:E261	R:R:R247	11.8048	4.65	Yes	Yes	0	4	4
5	R:R:R247	R:R:Y268	27.718	14.4	Yes	Yes	0	4	5
6	R:R:H269	R:R:Y268	23.8399	10.89	Yes	Yes	1	5	5
7	R:R:D81	R:R:F167	25.5263	5.97	Yes	Yes	1	4	4
8	R:R:D81	R:R:F77	27.3801	5.97	Yes	Yes	1	4	5
9	R:R:D81	R:R:F265	12.5553	4.78	Yes	Yes	1	4	4
10	R:R:F77	R:R:H269	43.8225	6.79	Yes	Yes	1	5	5
11	R:R:F77	R:R:Y24	75.8193	8.25	Yes	Yes	0	5	9
12	R:R:S276	R:R:Y24	26.4532	6.36	No	Yes	0	7	9
13	R:R:L70	R:R:Y24	26.5219	10.55	No	Yes	0	8	9
14	R:R:D81	R:R:Y76	15.8085	14.94	Yes	Yes	1	4	6
15	R:R:W73	R:R:Y76	22.4285	7.72	No	Yes	0	7	6
16	R:R:F97	R:R:W73	26.3455	20.04	Yes	No	0	7	7
17	R:R:F97	R:R:Y24	26.8778	8.25	Yes	Yes	0	7	9
18	R:R:F97	R:R:Y66	53.017	13.41	Yes	Yes	0	7	7
19	R:R:C279	R:R:Y66	100	9.41	No	Yes	0	9	7
20	R:R:C279	R:R:D63	99.1149	6.22	No	Yes	0	9	9
21	R:R:D63	R:R:N35	61.7839	6.73	Yes	Yes	0	9	9
22	R:R:N35	R:R:P283	25.4276	13.03	Yes	No	0	9	9
23	R:R:P283	R:R:T34	10.3666	6.99	No	No	0	9	7
24	R:R:L70	R:R:Y66	27.114	8.21	No	Yes	0	8	7
25	R:R:S276	R:R:Y66	28.5642	7.63	No	Yes	0	7	7
26	R:R:Y240	R:R:Y268	21.3162	7.94	Yes	Yes	1	6	5
27	R:R:H241	R:R:Y240	21.684	8.71	Yes	Yes	0	8	6
28	R:R:F190	R:R:H241	24.1718	19.23	No	Yes	0	8	8
29	R:R:F190	R:R:F237	23.9864	6.43	No	Yes	0	8	8
30	R:R:F237	R:R:N278	23.6246	12.08	Yes	No	3	8	9
31	R:R:D282	R:R:N278	24.5306	10.77	Yes	No	3	9	9
32	R:R:D282	R:R:D63	63.0666	6.65	Yes	Yes	0	9	9
33	R:R:N35	R:R:S60	33.5516	2.98	Yes	No	0	9	8
34	R:R:L39	R:R:S60	31.922	3	No	No	0	7	8
35	R:R:L39	R:R:M57	30.2864	5.65	No	No	0	7	5
36	R:R:M57	R:R:Y43	26.9974	4.79	No	No	0	5	4
37	R:R:Q47	R:R:Y43	25.3439	7.89	No	No	0	6	4
38	R:R:Q47	R:R:R44	23.6844	8.18	No	No	0	6	4
39	R:R:D296	R:R:R44	18.7537	5.96	No	No	0	4	4
40	R:R:D282	R:R:L108	75.4814	9.5	Yes	Yes	3	9	8
41	R:R:L108	R:R:Y286	71.5973	9.38	Yes	No	0	8	9
42	R:R:I111	R:R:Y286	24.698	4.84	Yes	No	0	9	9
43	R:R:I111	R:R:Y55	18.7418	3.63	Yes	Yes	0	9	7
44	R:R:M174	R:R:R247	10.3516	6.2	No	Yes	0	1	4
45	R:R:M181	R:R:R185	13.551	4.96	No	Yes	0	4	5
46	R:R:M181	R:R:N149	10.1453	4.21	No	No	0	4	7
47	R:R:E145	R:R:N149	15.7487	3.94	Yes	No	0	7	7
48	R:R:E145	R:R:I103	10.5938	4.1	Yes	No	0	7	7
49	R:R:N100	R:R:Y66	29.7273	4.65	Yes	Yes	0	8	7
50	R:R:G94	R:R:W73	14.167	4.22	No	No	0	6	7
51	R:R:W83	R:R:Y76	15.0251	4.82	Yes	Yes	1	9	6
52	R:R:F169	R:R:G94	13.0995	6.02	No	No	0	4	6
53	R:R:N149	R:R:T99	14.8248	5.85	No	Yes	0	7	5
54	R:R:R185	R:R:Y98	12.8902	4.12	Yes	No	0	5	5
55	R:R:L229	R:R:Y286	47.1684	11.72	No	No	0	8	9
56	R:R:L229	R:R:Y201	41.0298	5.86	No	Yes	0	8	8
57	R:R:S112	R:R:Y201	17.8896	8.9	No	Yes	0	9	8
58	R:R:S112	R:R:S200	15.7368	4.89	No	No	0	9	8
59	R:R:S200	R:R:Y116	13.56	2.54	No	Yes	0	8	8
60	R:R:M174	R:R:Y251	10.9496	8.38	No	Yes	0	1	3
61	R:R:I204	R:R:Y201	14.4211	4.84	No	Yes	0	8	8
62	R:R:I204	R:R:V208	11.1918	1.54	No	No	0	8	8
63	R:R:F260	R:R:R247	12.1606	4.28	Yes	Yes	0	1	4
64	R:R:A38	R:R:P283	13.6856	1.87	No	No	0	9	9
65	R:R:A38	R:R:C287	11.9842	3.61	No	Yes	0	9	7
66	R:R:D296	R:R:K299	17.16	2.77	No	No	0	4	5
67	R:R:K299	R:R:N303	10.3666	1.4	No	No	0	5	3
68	R:R:C9	R:R:E261	11.6673	4.56	No	Yes	1	8	4
69	R:R:N100	R:R:T99	19.6807	4.39	Yes	Yes	0	8	5
70	R:R:F97	R:R:Y98	13.4015	7.22	Yes	No	0	7	5
71	R:R:D16	R:R:H269	17.6265	7.56	Yes	Yes	1	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8Z9O_nogp

PDB Summary
PDB	8Z9O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.94
Number of Linked Nodes	286
Number of Links	325
Number of Hubs	50
Number of Links mediated by Hubs	179
Number of Communities	7
Number of Nodes involved in Communities	57
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	71345
Length Of Smallest Path	3
Average Path Length	13.4871
Length of Longest Path	26
Minimum Path Strength	1.215
Average Path Strength	7.45218
Maximum Path Strength	22.875
Minimum Path Correlation	0.7
Average Path Correlation	0.944252
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	54.8955
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.9963
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • G-protein beta-subunit binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • regulation of cell adhesion • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • positive regulation of defense response • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cell communication • small GTPase-mediated signal transduction • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • Rho protein signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • regulation of vascular permeability • circulatory system process • vascular process in circulatory system • blood circulation • cellular developmental process • connective tissue development • mesangial cell development • cell development • epithelial cell differentiation • renal system development • kidney vasculature development • pericyte cell differentiation • renal system vasculature development • mesangial cell differentiation • cell differentiation • nephron development • epithelial cell differentiation involved in kidney development • blood vessel development • glomerular mesangium development • glomerular mesangial cell development • vasculature development • glomerular mesangial cell differentiation • circulatory system development • glomerulus development • epithelial cell development • cell differentiation involved in kidney development • glomerulus vasculature development • kidney development • regulation of developmental process • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • regulation of angiogenesis • negative regulation of multicellular organismal process • response to pH • response to abiotic stimulus • response to acidic pH • angiogenesis involved in wound healing
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46093
Sequence	>8Z9O_nogp_Chain_R G C H V D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q R N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H D N W I H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H P L R F A R L R R V K T A V A V S S V V W A T E L G A N S A P L F H D E L F R D R Y N H T F C F E K F P M E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G S V S T E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P W D C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G A R S D V A K A L H N L L R F L A S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JCP	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZCE	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCE (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFU	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	3.23	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8Z3M	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-04-23	To be published
	8Z3M (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	To be published
	8Z3Q	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-04-23	To be published
	8Z3Q (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.76	2025-04-23	To be published
	8Z65	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-04-23	To be published
	8Z65 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.98	2025-04-23	To be published
	8Z66	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.06	2025-04-23	To be published
	8Z67	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-04-23	To be published
	9LMO	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-07-09	To be published
	9LMP	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	2.65	2025-07-02	To be published
	8Z3Y	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2025-06-04	To be published
	8Z3Y (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.2	2025-06-04	To be published
	8Z9P	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gi1/β1/γ2	2.5	2025-07-09	To be published
	8Z9P (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.5	2025-07-09	To be published
	9IV6	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.71	2025-07-30	To be published
	9IV6 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.71	2025-07-30	To be published
	8Z9O	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.4	2025-07-16	To be published
	8Z9O (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.4	2025-07-16	To be published

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