Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y24 6.15419
2R:R:L52 5.39458
3R:R:V54 3.2775477
4R:R:D63 5.4775419
5R:R:Y66 10.38417
6R:R:L70 4.81518
7R:R:W83 7.98839
8R:R:F93 7.8775436
9R:R:F95 4.6825406
10R:R:F97 6.706507
11R:R:Y98 7.6675425
12R:R:Y102 5.6075407
13R:R:F107 6.0625468
14R:R:C109 3.3775408
15R:R:R115 4.33659
16R:R:Y116 4.312548
17R:R:W142 5.8625469
18R:R:F159 5.2975402
19R:R:R162 7.98524
20R:R:F167 5.415404
21R:R:N182 5.3525
22R:R:R185 8.022525
23R:R:V186 3.555405
24R:R:M197 5.7475407
25R:R:F237 7.3325418
26R:R:Y240 7.3426
27R:R:L244 6.695425
28R:R:R247 7.5175404
29R:R:Y268 6.38667625
30R:R:N278 6.505419
31R:R:C279 4.298519
32R:R:P283 5.4925409
33R:R:Y286 4.49409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L23 R:R:S276 18.65964.5NoNo057
2R:R:L23 R:R:L277 12.70416.92NoNo055
3R:R:S276 R:R:Y24 20.75115.09NoYes079
4R:R:L70 R:R:Y24 25.089411.72YesYes189
5R:R:N35 R:R:P283 24.08658.15NoYes099
6R:R:D63 R:R:N35 32.71658.08YesNo099
7R:R:C279 R:R:D63 63.12393.11YesYes199
8R:R:C279 R:R:Y66 59.59424.03YesYes197
9R:R:L70 R:R:Y66 43.51583.52YesYes187
10R:R:D282 R:R:P283 23.88434.83NoYes099
11R:R:D282 R:R:D63 25.39266.65NoYes199
12R:R:A38 R:R:P283 37.07823.74NoYes099
13R:R:A38 R:R:S60 33.43961.71NoNo098
14R:R:L39 R:R:S60 29.78546.01NoNo078
15R:R:L39 R:R:M57 22.43042.83NoNo075
16R:R:M57 R:R:Y43 18.72963.59NoNo054
17R:R:Q47 R:R:Y43 15.01321.13NoNo064
18R:R:Q47 R:R:R44 11.28133.5NoNo064
19R:R:Q45 R:R:Y286 15.12213.38NoYes059
20R:R:N50 R:R:Q45 21.225310.56NoNo075
21R:R:L52 R:R:N50 23.3092.75YesNo087
22R:R:L52 R:R:R115 26.61337.29YesYes589
23R:R:L225 R:R:R115 63.66042.43NoYes089
24R:R:L225 R:R:L229 68.62076.92NoNo088
25R:R:L229 R:R:S112 71.78516.01NoNo089
26R:R:M197 R:R:S112 73.419.2YesNo079
27R:R:C109 R:R:M197 84.34924.86YesYes087
28R:R:C109 R:R:P193 94.10673.77YesNo089
29R:R:I105 R:R:P193 98.6553.39NoNo089
30R:R:F237 R:R:I105 10011.3YesNo088
31R:R:F237 R:R:N278 37.5687.25YesYes189
32R:R:N100 R:R:N278 12.330910.9NoYes189
33R:R:N100 R:R:Y66 13.131726.75NoYes187
34R:R:C279 R:R:N278 29.96424.72YesYes199
35R:R:F97 R:R:Y66 64.86557.22YesYes077
36R:R:F97 R:R:I101 41.486511.3YesNo078
37R:R:I101 R:R:Y102 73.7914.84NoYes087
38R:R:E145 R:R:Y102 64.66343.37NoYes077
39R:R:E145 R:R:I103 53.12555.47NoNo077
40R:R:I103 R:R:W142 49.6898.22NoYes079
41R:R:F107 R:R:W142 24.1025.01YesYes689
42R:R:F107 R:R:Y55 20.27683.09YesNo087
43R:R:A134 R:R:Y55 16.28834NoNo087
44R:R:A134 R:R:V54 14.52345.09NoYes087
45R:R:W83 R:R:Y76 15.207614.47YesNo096
46R:R:F93 R:R:W83 17.12024.01YesYes369
47R:R:F93 R:R:G94 23.65111.51YesNo066
48R:R:F97 R:R:G94 25.2061.51YesNo076
49R:R:L146 R:R:W142 22.14276.83NoYes039
50R:R:F95 R:R:L146 20.16792.44YesNo063
51R:R:F167 R:R:Y76 13.62156.19YesNo046
52R:R:F97 R:R:Y98 46.4786.19YesYes075
53R:R:F159 R:R:Y163 23.27797.22YesNo023
54R:R:Y163 R:R:Y98 16.42055.96NoYes235
55R:R:R185 R:R:Y98 32.576612.35YesYes255
56R:R:R162 R:R:R185 10.02188.53YesYes245
57R:R:F167 R:R:F169 11.07915.36YesNo044
58R:R:F169 R:R:H269 14.36793.39NoNo045
59R:R:H269 R:R:Y268 27.63965.44NoYes055
60R:R:Y240 R:R:Y268 50.76977.94YesYes265
61R:R:R185 R:R:Y240 67.44673.09YesYes256
62R:R:I101 R:R:T275 68.37194.56NoNo088
63R:R:A106 R:R:E145 12.54083.02NoNo067
64R:R:I204 R:R:Y116 21.45084.84NoYes088
65R:R:I204 R:R:I222 23.51112.94NoNo087
66R:R:I222 R:R:R115 29.59882.51NoYes079
67R:R:C109 R:R:V113 10.91591.71YesNo086
68R:R:A106 R:R:V141 10.48831.7NoNo067
69R:R:L158 R:R:V178 10.06061.49NoNo052
70R:R:D161 R:R:K171 24.59181.38NoNo023
71R:R:K171 R:R:P173 28.04393.35NoNo034
72R:R:F172 R:R:P173 31.480323.12NoNo054
73R:R:F172 R:R:F265 34.54362.14NoNo054
74R:R:F265 R:R:H269 21.808421.5NoNo045
75R:R:D161 R:R:E175 21.12425.2NoNo022
76R:R:L244 R:R:N182 12.64978.24YesYes255
77R:R:F265 R:R:R247 18.38756.41NoYes044
78R:R:R247 R:R:Y268 24.397412.35YesYes045
79R:R:E175 R:R:G176 17.64113.27NoNo024
80R:R:H241 R:R:Y240 14.64787.62NoYes086
81R:R:L244 R:R:V186 11.59234.47YesYes055
82R:R:A179 R:R:G176 10.62821.95NoNo014
83R:R:N182 R:R:R185 12.64194.82YesYes255
84R:R:F237 R:R:T275 67.85885.19YesNo088
85R:R:R185 R:R:Y102 60.356111.32YesYes057
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9LMO
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.2
Date 2025-07-09
D.O.I. To be published
Net Summary
Imin 2.98
Number of Linked Nodes 242
Number of Links 270
Number of Hubs 33
Number of Links mediated by Hubs 122
Number of Communities 8
Number of Nodes involved in Communities 49
Number of Links involved in Communities 66
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 35178
Length Of Smallest Path 3
Average Path Length 13.6057
Length of Longest Path 33
Minimum Path Strength 1.355
Average Path Strength 5.90361
Maximum Path Strength 18.825
Minimum Path Correlation 0.7
Average Path Correlation 0.930895
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 52.9199
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.8607
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP46093
Sequence
>9LMO_Chain_R
HLFPPSLYI FVIGVGLPT NCLALWAAY RQVQQRNEL GVYLMNLSI 
ADLLYICTL PLWVDYFLH HDNWIHGPG SCKLFGFIF YTNIYISIA 
FLCCISVDR YLAVAHPLR FARLRRVKT AVAVSSVVW ATELGANSA 
PLFHDELFR DRYNHTFCF EKFPMEGWV AWMNLYRVF VGFLFPWAL 
MLLSYRGIL RAVIKRLAL SLIAIVLVC FAPYHVLLL SRSAIYLGR 
FEERVFSAY HSSLAFTSL NCVADPILY CLVNEGARS DVAKALHNL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LMO.zip



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