Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 10.7125474
2A:A:L30 3.8925475
3A:A:H41 5.846526
4A:A:L43 4.37427
5A:A:L45 4.71167628
6A:A:N50 6.79429
7A:A:S51 3.992529
8A:A:K53 5.614529
9A:A:I56 5.0125427
10A:A:R61 7.1275428
11A:A:E209 4.9875419
12A:A:F212 6.9925429
13A:A:V214 5.06426
14A:A:V217 5.5025425
15A:A:F219 6.87333628
16A:A:H220 10.7375417
17A:A:M221 4.3325408
18A:A:F222 10.805417
19A:A:D223 5.38429
20A:A:Q227 5.75619
21A:A:R228 7.7925409
22A:A:R232 7.34418
23A:A:K233 5.18286719
24A:A:W234 6.99333619
25A:A:C237 4.962518
26A:A:F238 8.53833619
27A:A:I245 4.822527
28A:A:F246 5.38409
29A:A:V247 4.9925427
30A:A:D249 9.315428
31A:A:D252 5.0575428
32A:A:Y253 6.87668
33A:A:R265 9.648529
34A:A:L270 6.825406
35A:A:F273 6.0256139
36A:A:W277 12.5065136
37A:A:W281 14.408515
38A:A:I288 5.71629
39A:A:L289 5.5675409
40A:A:F290 5.515629
41A:A:L291 4.265468
42A:A:Q294 7.338566
43A:A:L297 5.165468
44A:A:S306 3.0575467
45A:A:F312 4.83833698
46A:A:E314 3.51496
47A:A:F315 10.8596
48A:A:Y318 6.614596
49A:A:E330 7.922563
50A:A:V334 3.7775464
51A:A:K338 7.608565
52A:A:Y339 6.76333663
53A:A:F340 11.798597
54A:A:R342 6.26667664
55A:A:E344 8.0675495
56A:A:F345 7.806508
57A:A:C359 3.4925405
58A:A:Y360 10.245628
59A:A:H362 9.0525429
60A:A:F363 7.35565
61A:A:T364 5.635429
62A:A:D368 8.3825429
63A:A:N371 7.26167629
64A:A:R373 7.1975425
65A:A:R374 8.1425424
66A:A:I375 4.9025429
67A:A:F376 5.515828
68A:A:D381 6.865428
69A:A:I383 5.08528
70A:A:Q384 4.135406
71A:A:R385 5.812525
72A:A:H387 5.36833628
73A:A:L388 3.998528
74A:A:Y391 8.65143724
75A:A:L393 5.3475428
76A:A:L394 5.25833628
77B:B:L7 5.1175408
78B:B:L14 4.8925148
79B:B:T34 4.8525445
80B:B:I37 3.565642
81B:B:V40 5.32833643
82B:B:I43 4.1225443
83B:B:L51 7.82409
84B:B:H54 10.664579
85B:B:K57 13.21519
86B:B:Y59 9518
87B:B:M61 4.6475486
88B:B:W63 8.115687
89B:B:V71 5.372518
90B:B:Q75 8.66519
91B:B:D76 6.384509
92B:B:K78 4.60333678
93B:B:L79 4.402517
94B:B:I80 8.02578
95B:B:I81 5.035417
96B:B:W82 10.992579
97B:B:D83 11.015478
98B:B:Y85 10.5025484
99B:B:K89 6.97571779
100B:B:I93 6.365417
101B:B:L95 5.108518
102B:B:W99 8.31571719
103B:B:V100 3.9625419
104B:B:M101 4.98519
105B:B:Y105 5.13125816
106B:B:Y111 7.272514
107B:B:C114 4.58418
108B:B:L117 4.052519
109B:B:I123 4.225416
110B:B:Y124 5.59833616
111B:B:V133 6.4325414
112B:B:L139 9.2625409
113B:B:H142 7.24619
114B:B:Y145 6.74718
115B:B:C148 4.635456
116B:B:F151 4.67667619
117B:B:L152 6.162553
118B:B:I157 4.358517
119B:B:V158 5.3625455
120B:B:T159 5.722519
121B:B:S160 4.42456
122B:B:D163 9.75419
123B:B:T165 5.5375417
124B:B:C166 4.585458
125B:B:L168 4.1825456
126B:B:W169 9.14286718
127B:B:F180 8.244557
128B:B:H183 8.46286759
129B:B:D186 7.5775419
130B:B:V187 4.702559
131B:B:M188 5.34418
132B:B:L190 5.234555
133B:B:F199 7.64833659
134B:B:V200 7.488516
135B:B:S201 5.96459
136B:B:C204 5.21833617
137B:B:D205 6459
138B:B:S207 5.235455
139B:B:K209 9.402556
140B:B:W211 9.38667658
141B:B:F222 8.474518
142B:B:H225 7.955819
143B:B:D228 8.102519
144B:B:I232 4.08518
145B:B:F234 5.338515
146B:B:F235 5.7975846
147B:B:P236 6.7447
148B:B:F241 9.204516
149B:B:T243 7.3425418
150B:B:D246 7.57419
151B:B:D247 8.694519
152B:B:T249 7.584516
153B:B:R251 10.4283618
154B:B:F253 8.542516
155B:B:D258 9.5775417
156B:B:M262 5.1525444
157B:B:Y264 5.41833645
158B:B:H266 8.24444
159B:B:I269 4.51544
160B:B:I273 5.75446
161B:B:T274 3.685418
162B:B:S277 3.32405
163B:B:F278 5.59333647
164B:B:R283 7.438549
165B:B:L284 5.5375445
166B:B:L285 5.306546
167B:B:Y289 6.91571747
168B:B:D290 5.96833616
169B:B:N293 3.675445
170B:B:C294 4.53415
171B:B:N295 7.81646
172B:B:V296 3.915405
173B:B:W297 6.4825448
174B:B:L300 5.58546
175B:B:K301 4.1875405
176B:B:R304 12.2325445
177B:B:H311 8.328519
178B:B:R314 12.475618
179B:B:V315 4.176517
180B:B:L318 3.94167616
181B:B:V327 3.41416
182B:B:T329 5.138518
183B:B:W332 13.9214719
184B:B:D333 7.065419
185B:B:K337 8.5275416
186B:B:W339 8.762519
187B:B:N340 5.2775489
188G:G:L19 6.5675409
189G:G:E22 6.6025409
190G:G:Y40 10.42446
191G:G:D48 6.6425409
192G:G:L51 2.525406
193G:G:P60 8.95489
194G:G:F61 4.9825888
195R:R:P20 3.804505
196R:R:Y24 6.236539
197R:R:V27 4.3075437
198R:R:I28 3.12507
199R:R:N35 7.068509
200R:R:R44 8.1525404
201R:R:N50 6.6225407
202R:R:E51 6.275427
203R:R:L52 4.52333628
204R:R:Y55 6.284507
205R:R:Y66 7.76167637
206R:R:I67 3.6875406
207R:R:L70 6.7975438
208R:R:W73 11.4125437
209R:R:W83 12.1383639
210R:R:H85 7.5525407
211R:R:K91 6.595406
212R:R:F93 7.15636
213R:R:F95 5.866126
214R:R:F97 10.092537
215R:R:Y98 5.585405
216R:R:Y102 7.87537
217R:R:I103 6.944117
218R:R:F107 7.4985118
219R:R:L108 7.49428
220R:R:I111 4.864529
221R:R:D114 5.558528
222R:R:R115 6.814529
223R:R:Y116 6.334108
224R:R:L117 3.234106
225R:R:P122 4.36527
226R:R:L123 5.304526
227R:R:F125 7.60754106
228R:R:R129 5.89527
229R:R:W142 9.12254119
230R:R:N149 6.2654127
231R:R:S150 4.84754124
232R:R:F159 8.235432
233R:R:D161 5.7875432
234R:R:R162 9.15286734
235R:R:Y163 10.1075433
236R:R:F167 8.204531
237R:R:F169 6.955404
238R:R:E170 6.5534
239R:R:F172 8.0875405
240R:R:M174 5.424531
241R:R:E175 5.598532
242R:R:W177 6.89531
243R:R:V178 4.5432
244R:R:N182 4.76667635
245R:R:R185 9.3725435
246R:R:F190 6.126508
247R:R:Y201 6.55167608
248R:R:S213 6.9125423
249R:R:E218 11.13425
250R:R:I222 3.6725427
251R:R:L229 6.354528
252R:R:F237 6.40143738
253R:R:Y240 6.5275836
254R:R:H241 10.8625438
255R:R:R247 9.688534
256R:R:Y251 5.0425403
257R:R:L252 6.7775406
258R:R:Y268 10.818535
259R:R:S276 5.285437
260R:R:D282 9.56529
261R:R:Y286 7.1629
262R:R:C287 2.422508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F219 A:A:H41 38.15697.92YesYes286
2A:A:F219 A:A:L43 42.29716.09YesYes287
3A:A:L43 A:A:M221 14.46032.83YesYes078
4A:A:L45 A:A:M221 14.91675.65YesYes088
5A:A:K53 A:A:L45 29.56784.23YesYes298
6A:A:K53 A:A:S51 29.76386.12YesYes299
7A:A:A48 A:A:S51 30.77813.42NoYes289
8A:A:A48 A:A:N50 15.32463.13NoYes289
9A:A:D252 A:A:N50 15.31322.69YesYes289
10A:A:D252 A:A:N254 1002.69YesNo089
11A:A:N254 A:A:Y311 99.98599.3NoNo096
12A:A:Y253 A:A:Y311 99.78599.93YesNo686
13A:A:L266 A:A:Y253 93.44493.52NoYes088
14A:A:I341 A:A:L266 89.84564.28NoNo088
15A:A:I341 A:A:L291 89.82642.85NoYes088
16A:A:L289 A:A:L291 91.35116.92YesYes098
17A:A:F246 A:A:L289 90.67593.65YesYes099
18A:A:F246 A:A:L272 93.94649.74YesNo098
19A:A:L272 A:A:R231 93.396710.93NoNo089
20A:A:R231 A:A:W234 93.37057NoYes099
21A:A:F238 A:A:W234 38.00023.01YesYes199
22A:A:C237 A:A:F238 24.81682.79YesYes189
23B:B:Q75 B:B:V100 18.25182.87YesYes199
24B:B:L69 B:B:Y105 12.47527.03NoYes056
25A:A:I245 A:A:L43 21.18344.28YesYes277
26A:A:I245 A:A:L45 14.44824.28YesYes278
27A:A:A48 A:A:R265 15.47845.53NoYes289
28A:A:D252 A:A:R265 15.41579.53YesYes289
29A:A:F290 A:A:T364 68.29656.49YesYes299
30A:A:N292 A:A:T364 68.96925.85NoYes099
31A:A:K293 A:A:N292 69.31395.6NoNo099
32A:A:D249 A:A:K293 69.279817.97YesNo089
33A:A:D249 A:A:D252 69.29875.32YesYes288
34A:A:F238 B:B:W99 13.139213.03YesYes199
35A:A:W234 B:B:Y145 55.45063.86YesYes198
36B:B:M188 B:B:Y145 12.64.79YesYes188
37B:B:M188 B:B:S147 12.9023.07YesNo089
38B:B:S147 B:B:S160 12.82614.89NoYes096
39A:A:H41 A:A:I383 37.04156.63YesYes268
40A:A:K233 B:B:D228 11.7725.53YesYes199
41A:A:K233 B:B:D246 11.77244.15YesYes199
42B:B:R314 B:B:W332 17.747623.99YesYes189
43B:B:M101 B:B:Y59 16.95984.79YesYes198
44A:A:F290 A:A:H362 54.36166.79YesYes299
45A:A:R385 R:R:S213 53.68983.95YesYes253
46A:A:Y360 R:R:S213 53.57966.36YesYes283
47A:A:H362 A:A:Y360 54.62633.27YesYes298
48A:A:H387 A:A:I383 36.75856.63YesYes288
49A:A:L394 A:A:R385 52.74973.64YesYes285
50A:A:H387 A:A:Y391 19.51256.53YesYes284
51A:A:H387 R:R:R129 16.5727.9YesYes287
52A:A:L388 A:A:L394 26.09054.15YesYes288
53A:A:L388 A:A:L393 26.195.54YesYes288
54A:A:L393 R:R:I222 26.09032.85YesYes287
55A:A:L394 R:R:I222 26.08062.85YesYes287
56A:A:Y391 R:R:D114 15.99398.05YesYes248
57R:R:D114 R:R:R129 16.02463.57YesYes287
58A:A:L393 R:R:R115 38.71147.29YesYes289
59A:A:L393 R:R:I204 13.495.71YesNo086
60B:B:D228 B:B:S227 12.11555.89YesNo196
61B:B:S227 B:B:S245 23.65413.26NoNo169
62B:B:H225 B:B:S245 18.77329.76YesNo199
63B:B:D246 B:B:S227 11.69917.36YesNo196
64B:B:C271 B:B:D290 12.89314.67NoYes056
65B:B:C271 B:B:Y289 11.38464.03NoYes057
66R:R:R115 R:R:Y201 13.86778.23YesYes098
67R:R:I230 R:R:Y201 23.13797.25NoYes078
68R:R:I230 R:R:W194 22.34434.7NoNo076
69R:R:F190 R:R:W194 21.9673.01YesNo086
70R:R:F190 R:R:H241 20.591515.84YesYes088
71R:R:H241 R:R:Y240 14.709813.07YesYes386
72R:R:Y240 R:R:Y268 10.97927.94YesYes365
73R:R:I204 R:R:Y201 13.39343.63NoYes068
74R:R:R115 R:R:Y286 25.85026.17YesYes299
75R:R:D282 R:R:Y286 26.39764.6YesYes299
76R:R:D282 R:R:N278 10.852314.81YesNo099
77R:R:F237 R:R:N278 10.744710.87YesNo089
78R:R:D282 R:R:D63 15.56475.32YesNo099
79R:R:C279 R:R:D63 11.29714.67NoNo099
80R:R:C279 R:R:Y66 10.31595.38NoYes097
81R:R:D114 R:R:Y55 31.46726.9YesYes087
82R:R:A134 R:R:Y55 27.45755.34NoYes057
83R:R:A134 R:R:V54 26.87345.09NoNo055
84R:R:S138 R:R:V54 25.13574.85NoNo075
85R:R:F107 R:R:S138 14.63063.96YesNo1187
86R:R:L146 R:R:W142 17.53953.42NoYes039
87R:R:F95 R:R:L146 16.37297.31YesNo063
88R:R:F95 R:R:L153 10.16764.87YesNo1264
89B:B:R314 B:B:T274 10.86753.88YesYes188
90B:B:M101 B:B:Y145 17.71077.18YesYes198
91A:A:K233 B:B:Y145 23.69033.58YesYes198
92B:B:W332 B:B:Y59 33.10817.72YesYes198
93A:A:C237 B:B:Y59 16.17539.41YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9LGM
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.84
Date 2025-04-23
D.O.I. doi.org/10.1038/s41422-025-01092-w
Net Summary
Imin 2.69
Number of Linked Nodes 884
Number of Links 1245
Number of Hubs 262
Number of Links mediated by Hubs 897
Number of Communities 15
Number of Nodes involved in Communities 353
Number of Links involved in Communities 591
Path Summary
Number Of Nodes in MetaPath 94
Number Of Links MetaPath 93
Number of Shortest Paths 4258681
Length Of Smallest Path 3
Average Path Length 35.2455
Length of Longest Path 58
Minimum Path Strength 1.39
Average Path Strength 6.36444
Maximum Path Strength 25.225
Minimum Path Correlation 0.7
Average Path Correlation 0.992388
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 35.5193
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.6773
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • Ras protein signal transduction   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • ectodermal placode formation   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell-cell adhesion   • coagulation   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9LGM_Chain_A
KTEDQRNEE KAQREANKK IEKQLQKDK QVYRATHRL LLLGASGKS 
TIVKQMRIL HSGIFETKF QVDKVNFHM FDVGGQRDE RRKWIQCFN 
DVTAIIFVV SSYNRLQEA LNLFKSIWN NRWLRTISV ILFLNKQDL 
LAEKVLAGK SKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCAVD TENRRFNDC RDIIQRMHL 
RQYELLDNG GDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9LGM_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9LGM_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9LGM_Chain_R
DSRVDHLFP PSLYIVIGV GLPTNCLAL WAAYRQVQQ RNELGYLML 
SIADLYICT LPWVDYFHH DNWIHGPGS CKLFFIFYT NIYISIAFL 
CCIVDRYLA VAHPLRFRL RRVTVAVSS VVWATELGA NSAPLFHDE 
LFRDRYNHT CFEKFPMEG WVAWMNLYR FVGFFPWAM LSYRLRVRG 
SVSTERQEK AKIKLALSL AIVLVCFAP YHVLLSRSA IYGRPWDCG 
FEERVFSAY HSSAFTSLN CVDPIYLVN EGARSDAKA FVNLLLGSA 
KAFVLLLGI ARILLLALC V


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LGM.zip



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