psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L15	R:R:R80	3.64	No	No	0	5	3
2	R:R:D16	R:R:L19	9.5	No	No	0	5	5
3	R:R:R80	R:R:S17	10.54	No	No	0	3	4
4	R:R:L19	R:R:P20	4.93	No	No	0	5	5
5	R:R:L19	R:R:L23	8.3	No	No	0	5	4
6	R:R:P20	R:R:P21	7.79	No	No	2	5	6
7	R:R:P20	R:R:Y77	8.34	No	Yes	2	5	5
8	R:R:P21	R:R:Y77	5.56	No	Yes	2	6	5
9	R:R:A280	R:R:L23	4.73	No	No	0	4	4
10	R:R:L70	R:R:Y24	3.52	No	Yes	0	8	8
11	R:R:Y24	R:R:Y77	13.9	Yes	Yes	0	8	5
12	R:R:T283	R:R:Y24	7.49	No	Yes	0	7	8
13	R:R:F28	R:R:L32	6.09	No	No	5	7	5
14	R:R:F28	R:R:I67	8.79	No	Yes	5	7	5
15	R:R:F28	R:R:P71	7.22	No	No	0	7	9
16	R:R:G31	R:R:L287	5.13	Yes	No	0	8	6
17	R:R:L32	R:R:P33	4.93	No	No	0	5	4
18	R:R:I67	R:R:L32	17.13	Yes	No	5	5	5
19	R:R:N35	R:R:S60	4.47	Yes	No	0	9	9
20	R:R:D63	R:R:N35	18.85	No	Yes	0	9	9
21	R:R:L64	R:R:N35	4.12	No	Yes	0	7	9
22	R:R:N35	R:R:P290	9.77	Yes	No	0	9	9
23	R:R:L36	R:R:L64	4.15	No	No	0	3	7
24	R:R:L37	R:R:V304	13.41	No	No	0	5	6
25	R:R:L39	R:R:S60	4.5	No	No	0	7	9
26	R:R:E303	R:R:W40	6.54	Yes	No	0	6	3
27	R:R:V46	R:R:W43	4.9	Yes	No	0	5	3
28	R:R:R47	R:R:W43	14.99	No	No	0	6	3
29	R:R:E303	R:R:L44	9.28	Yes	No	0	6	4
30	R:R:Q45	R:R:R50	7.01	No	No	0	5	7
31	R:R:G53	R:R:V46	3.68	No	Yes	0	7	5
32	R:R:K48	R:R:R50	3.71	No	No	0	5	7
33	R:R:E51	R:R:Y55	8.98	Yes	Yes	1	6	7
34	R:R:D114	R:R:E51	16.89	Yes	Yes	1	8	6
35	R:R:E51	R:R:F125	10.49	Yes	Yes	1	6	5
36	R:R:E51	R:R:P126	4.72	Yes	Yes	1	6	5
37	R:R:E51	R:R:P130	11	Yes	No	1	6	5
38	R:R:L52	R:R:V111	8.94	No	No	1	7	8
39	R:R:D114	R:R:L52	8.14	Yes	No	1	8	7
40	R:R:L52	R:R:R115	4.86	No	Yes	1	7	9
41	R:R:V54	R:R:Y55	6.31	No	Yes	1	6	7
42	R:R:C110	R:R:Y55	6.72	No	Yes	0	6	7
43	R:R:D114	R:R:Y55	3.45	Yes	Yes	1	8	7
44	R:R:A134	R:R:Y55	5.34	No	Yes	0	8	7
45	R:R:L56	R:R:Y293	3.52	No	Yes	0	8	9
46	R:R:F107	R:R:N58	14.5	Yes	No	3	7	9
47	R:R:N58	R:R:S138	8.94	No	No	3	9	7
48	R:R:N58	R:R:W142	9.04	No	Yes	3	9	9
49	R:R:D289	R:R:L59	10.86	Yes	No	0	9	9
50	R:R:L61	R:R:W142	3.42	No	Yes	0	6	9
51	R:R:S62	R:R:V103	4.85	No	No	3	8	7
52	R:R:S62	R:R:W142	4.94	No	Yes	3	8	9
53	R:R:C286	R:R:D63	10.89	No	No	0	7	9
54	R:R:L65	R:R:N100	12.36	No	No	0	7	9
55	R:R:F97	R:R:L66	3.65	No	No	0	7	7
56	R:R:L66	R:R:N100	9.61	No	No	0	7	9
57	R:R:C286	R:R:L66	4.76	No	No	0	7	7
58	R:R:P71	R:R:P72	5.84	No	No	0	9	6
59	R:R:F93	R:R:P72	17.34	No	No	0	5	6
60	R:R:W73	R:R:Y76	6.75	Yes	Yes	2	6	6
61	R:R:W73	R:R:W83	5.62	Yes	Yes	2	6	8
62	R:R:F97	R:R:W73	10.02	No	Yes	0	7	6
63	R:R:Y76	R:R:Y77	6.95	Yes	Yes	2	6	5
64	R:R:D81	R:R:Y76	8.05	Yes	Yes	2	4	6
65	R:R:W83	R:R:Y76	13.5	Yes	Yes	2	8	6
66	R:R:F167	R:R:Y76	4.13	Yes	Yes	2	3	6
67	R:R:H276	R:R:Y76	4.36	Yes	Yes	2	5	6
68	R:R:H276	R:R:Y77	19.6	Yes	Yes	2	5	5
69	R:R:D81	R:R:H165	3.78	Yes	No	0	4	3
70	R:R:D81	R:R:F167	11.94	Yes	Yes	2	4	3
71	R:R:D81	R:R:H276	7.56	Yes	Yes	2	4	5
72	R:R:N164	R:R:V82	14.78	No	No	0	6	4
73	R:R:W83	R:R:Y85	3.86	Yes	No	0	8	6
74	R:R:C90	R:R:W83	9.14	No	Yes	2	9	8
75	R:R:C168	R:R:W83	5.22	Yes	Yes	2	9	8
76	R:R:F93	R:R:Y85	4.13	No	No	0	5	6
77	R:R:G86	R:R:P87	4.06	No	No	0	8	3
78	R:R:C168	R:R:C90	7.28	Yes	No	2	9	9
79	R:R:L153	R:R:R91	15.79	No	No	0	4	7
80	R:R:F95	R:R:T99	7.78	Yes	No	4	5	4
81	R:R:F95	R:R:L146	3.65	Yes	No	0	5	3
82	R:R:F95	R:R:N149	3.62	Yes	Yes	4	5	6
83	R:R:F95	R:R:L153	7.31	Yes	No	0	5	4
84	R:R:F97	R:R:Y98	6.19	No	No	0	7	5
85	R:R:Y241	R:R:Y98	3.97	Yes	No	0	7	5
86	R:R:N149	R:R:T99	13.16	Yes	No	4	6	4
87	R:R:L101	R:R:Y102	3.52	No	Yes	0	7	7
88	R:R:L101	R:R:Y238	5.86	No	Yes	0	7	8
89	R:R:L101	R:R:Y241	3.52	No	Yes	0	7	7
90	R:R:E145	R:R:Y102	3.37	Yes	Yes	0	7	7
91	R:R:N149	R:R:Y102	8.14	Yes	Yes	4	6	7
92	R:R:R186	R:R:Y102	18.52	No	Yes	4	6	7
93	R:R:V103	R:R:W142	9.81	No	Yes	3	7	9
94	R:R:E145	R:R:V103	9.98	Yes	No	0	7	7
95	R:R:A106	R:R:E145	4.53	No	Yes	0	6	7
96	R:R:F107	R:R:S138	6.61	Yes	No	3	7	7
97	R:R:F107	R:R:I141	7.54	Yes	No	0	7	6
98	R:R:F107	R:R:W142	7.02	Yes	Yes	3	7	9
99	R:R:L108	R:R:N285	4.12	No	Yes	1	8	9
100	R:R:D289	R:R:L108	12.21	Yes	No	1	9	8
101	R:R:L108	R:R:Y293	4.69	No	Yes	1	8	9
102	R:R:P194	R:R:S109	3.56	Yes	No	0	9	7
103	R:R:S109	R:R:V197	8.08	No	No	0	7	6
104	R:R:R115	R:R:V111	5.23	Yes	No	1	9	8
105	R:R:M198	R:R:S112	6.13	No	No	0	7	9
106	R:R:C201	R:R:S112	5.16	No	No	0	7	9
107	R:R:S112	R:R:Y202	15.26	No	Yes	0	9	9
108	R:R:D114	R:R:F125	5.97	Yes	Yes	1	8	5
109	R:R:R115	R:R:Y202	5.14	Yes	Yes	0	9	9
110	R:R:R115	R:R:Y293	8.23	Yes	Yes	1	9	9
111	R:R:L117	R:R:Y116	3.52	No	Yes	0	6	8
112	R:R:A120	R:R:Y116	5.34	No	Yes	7	7	8
113	R:R:H121	R:R:Y116	4.36	No	Yes	7	6	8
114	R:R:C201	R:R:Y116	6.72	No	Yes	0	7	8
115	R:R:F125	R:R:L117	17.05	Yes	No	0	5	6
116	R:R:L205	R:R:V119	7.45	No	No	0	8	8
117	R:R:A120	R:R:H121	7.32	No	No	7	7	6
118	R:R:F125	R:R:P126	7.22	Yes	Yes	1	5	5
119	R:R:P126	R:R:P130	9.74	Yes	No	1	5	5
120	R:R:R129	R:R:R132	15.99	No	No	0	7	4
121	R:R:E145	R:R:I141	4.1	Yes	No	0	7	6
122	R:R:N149	R:R:P152	4.89	Yes	No	4	6	4
123	R:R:N149	R:R:R186	6.03	Yes	No	4	6	6
124	R:R:P151	R:R:P152	9.74	No	No	0	8	4
125	R:R:P152	R:R:R186	11.53	No	No	4	4	6
126	R:R:E156	R:R:L154	5.3	No	No	0	6	4
127	R:R:R160	R:R:T166	10.35	No	No	0	1	5
128	R:R:D161	R:R:R162	3.57	No	No	0	1	2
129	R:R:D161	R:R:H165	3.78	No	No	0	1	3
130	R:R:N164	R:R:Y163	3.49	No	No	0	6	2
131	R:R:E170	R:R:F167	18.66	No	Yes	2	6	3
132	R:R:F167	R:R:Y172	14.44	Yes	Yes	2	3	5
133	R:R:E170	R:R:Y172	12.35	No	Yes	2	6	5
134	R:R:R248	R:R:Y172	9.26	Yes	Yes	0	5	5
135	R:R:F272	R:R:Y172	7.22	No	Yes	0	4	5
136	R:R:F252	R:R:P173	5.78	No	No	0	4	6
137	R:R:L174	R:R:R248	6.07	Yes	Yes	0	3	5
138	R:R:F252	R:R:L174	17.05	No	Yes	0	4	3
139	R:R:L181	R:R:R177	4.86	No	No	0	3	1
140	R:R:L253	R:R:R177	4.86	No	No	0	4	1
141	R:R:L245	R:R:N183	16.48	No	No	0	6	5
142	R:R:N183	R:R:S249	4.47	No	No	0	5	5
143	R:R:S249	R:R:V184	4.85	No	Yes	0	5	4
144	R:R:H242	R:R:V187	4.15	No	Yes	0	8	6
145	R:R:L246	R:R:V187	11.92	No	Yes	0	6	6
146	R:R:F191	R:R:W195	6.01	No	No	0	9	6
147	R:R:F191	R:R:H242	14.71	No	No	0	9	8
148	R:R:M199	R:R:W195	20.94	No	No	0	4	6
149	R:R:L235	R:R:W195	13.67	No	No	0	5	6
150	R:R:G196	R:R:M199	3.49	No	No	0	2	4
151	R:R:A227	R:R:Y202	5.34	No	Yes	0	7	9
152	R:R:P231	R:R:Y202	6.95	No	Yes	0	7	9
153	R:R:R207	R:R:R210	6.4	No	No	0	4	5
154	R:R:L209	R:R:V223	4.47	No	No	0	8	7
155	R:R:C215	R:R:S212	3.44	No	No	0	2	5
156	R:R:C215	R:R:R220	4.18	No	No	0	2	6
157	R:R:L230	R:R:L292	11.07	No	No	0	7	7
158	R:R:L230	R:R:Y293	9.38	No	Yes	0	7	9
159	R:R:L292	R:R:V233	4.47	No	No	0	7	6
160	R:R:C237	R:R:N285	4.72	No	Yes	0	8	9
161	R:R:N285	R:R:Y238	16.28	Yes	Yes	0	9	8
162	R:R:G239	R:R:P240	4.06	No	No	0	6	9
163	R:R:P240	R:R:S278	5.34	No	No	0	9	7
164	R:R:H242	R:R:Y241	9.8	No	Yes	0	8	7
165	R:R:L245	R:R:Y241	3.52	No	Yes	6	6	7
166	R:R:Y241	R:R:Y275	11.91	Yes	Yes	6	7	6
167	R:R:S278	R:R:Y241	3.82	No	Yes	0	7	7
168	R:R:L279	R:R:Y241	8.21	No	Yes	0	6	7
169	R:R:L244	R:R:Y275	7.03	No	Yes	0	5	6
170	R:R:L245	R:R:Y275	4.69	No	Yes	6	6	6
171	R:R:E268	R:R:R248	11.63	No	Yes	0	4	5
172	R:R:R248	R:R:Y275	15.43	Yes	Yes	0	5	6
173	R:R:L267	R:R:V251	4.47	No	No	0	1	4
174	R:R:A266	R:R:R270	4.15	No	No	0	4	3
175	R:R:L267	R:R:L271	9.69	No	No	0	1	4
176	R:R:F272	R:R:P273	7.22	No	No	0	4	3
177	R:R:F272	R:R:H276	4.53	No	Yes	0	4	5
178	R:R:D289	R:R:N285	13.46	Yes	Yes	1	9	9
179	R:R:D289	R:R:Y293	5.75	Yes	Yes	1	9	9
180	R:R:A300	R:R:C294	3.61	No	Yes	0	8	6
181	R:R:C297	R:R:P298	3.77	No	No	0	7	6
182	R:R:G302	R:R:R301	6	No	No	0	4	8
183	R:R:A305	R:R:R301	4.15	No	No	0	5	8
184	R:R:E303	R:R:K306	6.75	Yes	No	0	6	6
185	R:R:L193	R:R:P194	3.28	No	Yes	0	5	9
186	R:R:S171	R:R:S175	3.26	No	No	0	4	3
187	R:R:S212	R:R:S214	3.26	No	No	0	5	3
188	R:R:T166	R:R:V82	3.17	No	No	0	5	4
189	R:R:A180	R:R:L174	3.15	No	Yes	0	3	3
190	R:R:I141	R:R:V137	3.07	No	No	0	6	5
191	R:R:I158	R:R:T166	3.04	No	No	0	4	5
192	R:R:C215	R:R:E219	3.04	No	No	0	2	5
193	R:R:L23	R:R:S22	3	No	No	0	4	3
194	R:R:L70	R:R:V27	2.98	No	No	0	8	7
195	R:R:L209	R:R:V119	2.98	No	No	0	8	8
196	R:R:L30	R:R:T29	2.95	No	No	0	5	4
197	R:R:L78	R:R:T74	2.95	No	No	0	5	7
198	R:R:G204	R:R:Y116	2.9	No	Yes	0	4	8
199	R:R:K48	R:R:L44	2.82	No	No	0	5	4
200	R:R:G94	R:R:W73	2.81	No	Yes	0	6	6
201	R:R:G86	R:R:W83	2.81	No	Yes	0	8	8
202	R:R:L188	R:R:L192	2.77	No	No	8	4	4
203	R:R:L206	R:R:L228	2.77	No	No	9	5	4
204	R:R:L244	R:R:L271	2.77	No	No	0	5	4
205	R:R:L247	R:R:L271	2.77	No	No	0	5	4
206	R:R:A105	R:R:Y238	2.67	No	Yes	0	8	8
207	R:R:A282	R:R:Y238	2.67	No	Yes	0	8	8
208	R:R:T74	R:R:Y24	2.5	No	Yes	0	7	8
209	R:R:F93	R:R:L92	2.44	No	No	0	5	5
210	R:R:L206	R:R:R224	2.43	No	No	0	5	5
211	R:R:R218	R:R:R221	2.13	No	No	10	3	5
212	R:R:G263	R:R:G264	2.11	No	No	0	2	3
213	R:R:G88	R:R:P87	2.03	No	No	0	2	3
214	R:R:G127	R:R:P126	2.03	No	Yes	0	4	5
215	R:R:G190	R:R:P194	2.03	No	Yes	0	6	9
216	R:R:G229	R:R:P231	2.03	No	No	0	5	7
217	R:R:G299	R:R:P298	2.03	No	No	0	6	6
218	R:R:C232	R:R:G229	1.96	No	No	0	4	5
219	R:R:A34	R:R:G31	1.95	No	Yes	0	7	8
220	R:R:A89	R:R:G86	1.95	No	No	0	5	8
221	R:R:A203	R:R:G204	1.95	No	No	0	3	4
222	R:R:A38	R:R:P290	1.87	No	No	0	9	9
223	R:R:W40	R:R:W43	1.87	No	No	0	3	3
224	R:R:A105	R:R:P194	1.87	No	Yes	0	8	9
225	R:R:A150	R:R:P151	1.87	No	No	0	3	8
226	R:R:G185	R:R:V184	1.84	No	Yes	0	3	4
227	R:R:A38	R:R:C294	1.81	No	Yes	0	9	6
228	R:R:A41	R:R:C294	1.81	No	Yes	0	7	6
229	R:R:A113	R:R:C201	1.81	No	No	0	5	7
230	R:R:A300	R:R:C297	1.81	No	No	0	8	7
231	R:R:A120	R:R:A208	1.79	No	No	0	7	5
232	R:R:G31	R:R:I67	1.76	Yes	Yes	0	8	5
233	R:R:G31	R:R:L30	1.71	Yes	No	0	8	5
234	R:R:G104	R:R:L59	1.71	No	No	0	9	9
235	R:R:A179	R:R:S175	1.71	No	No	0	3	3
236	R:R:G264	R:R:L267	1.71	No	No	0	3	1
237	R:R:C294	R:R:V304	1.71	Yes	No	0	6	6
238	R:R:A69	R:R:V96	1.7	No	No	0	6	5
239	R:R:A208	R:R:V119	1.7	No	No	0	5	8
240	R:R:A288	R:R:V233	1.7	No	No	0	6	6
241	R:R:C68	R:R:I67	1.64	No	Yes	0	4	5
242	R:R:C90	R:R:I158	1.64	No	No	2	9	4
243	R:R:C168	R:R:I158	1.64	Yes	No	2	9	4
244	R:R:L281	R:R:P240	1.64	No	No	0	7	9
245	R:R:S133	R:R:V137	1.62	No	No	0	1	5
246	R:R:A234	R:R:M198	1.61	No	No	0	9	7
247	R:R:V46	R:R:V54	1.6	Yes	No	1	5	6
248	R:R:C237	R:R:L284	1.59	No	No	0	8	5
249	R:R:A42	R:R:L56	1.58	No	No	0	6	8
250	R:R:A42	R:R:L57	1.58	No	No	0	6	5
251	R:R:A227	R:R:L206	1.58	No	No	9	7	5
252	R:R:A296	R:R:L226	1.58	No	No	0	6	7
253	R:R:A227	R:R:L228	1.58	No	No	9	7	4
254	R:R:I131	R:R:V46	1.54	No	Yes	1	3	5
255	R:R:I131	R:R:V54	1.54	No	No	1	3	6
256	R:R:H121	R:R:P122	1.53	No	No	0	6	8
257	R:R:F252	R:R:G176	1.51	No	No	0	4	1
258	R:R:A266	R:R:E269	1.51	No	No	0	4	2
259	R:R:G155	R:R:R91	1.5	No	No	0	3	7
260	R:R:L174	R:R:S171	1.5	Yes	No	0	3	4
261	R:R:G178	R:R:R177	1.5	No	No	0	3	1
262	R:R:G204	R:R:R207	1.5	No	No	0	4	4
263	R:R:G211	R:R:R210	1.5	No	No	0	4	5
264	R:R:L92	R:R:V96	1.49	No	No	0	5	5
265	R:R:L181	R:R:V184	1.49	No	Yes	0	3	4
266	R:R:L188	R:R:V184	1.49	No	Yes	0	4	4
267	R:R:L188	R:R:V187	1.49	No	Yes	8	4	6
268	R:R:L192	R:R:V187	1.49	No	Yes	8	4	6
269	R:R:P130	R:R:R129	1.44	No	No	0	5	7
270	R:R:E303	R:R:V307	1.43	Yes	No	0	6	3
271	R:R:G84	R:R:W83	1.41	No	Yes	0	3	8
272	R:R:L200	R:R:M199	1.41	No	No	0	4	4
273	R:R:L26	R:R:L30	1.38	No	No	0	4	5
274	R:R:L26	R:R:L287	1.38	No	No	0	4	6
275	R:R:L140	R:R:L144	1.38	No	No	0	3	4
276	R:R:L226	R:R:L230	1.38	No	No	0	7	7
277	R:R:D75	R:R:L78	1.36	No	No	0	4	5
278	R:R:C168	R:R:Y169	1.34	Yes	No	0	9	3
279	R:R:R79	R:R:V82	1.31	No	No	0	4	4
280	R:R:N164	R:R:R80	1.21	No	No	0	6	3
281	R:R:Q217	R:R:R218	1.17	No	No	10	3	3
282	R:R:Q217	R:R:R220	1.17	No	No	0	3	6
283	R:R:Q217	R:R:R221	1.17	No	No	10	3	5
284	R:R:R221	R:R:R225	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y24	6.8525	4	0	8
2	R:R:G31	2.6375	4	0	8
3	R:R:N35	9.3025	4	0	9
4	R:R:V46	2.93	4	1	5
5	R:R:E51	10.416	5	1	6
6	R:R:Y55	6.16	5	1	7
7	R:R:I67	7.33	4	5	5
8	R:R:W73	6.3	4	2	6
9	R:R:Y76	7.29	6	2	6
10	R:R:Y77	10.87	5	2	5
11	R:R:D81	7.8325	4	2	4
12	R:R:W83	5.93714	7	2	8
13	R:R:F95	5.59	4	4	5
14	R:R:Y102	8.3875	4	4	7
15	R:R:F107	8.9175	4	3	7
16	R:R:D114	8.6125	4	1	8
17	R:R:R115	5.865	4	1	9
18	R:R:Y116	4.568	5	7	8
19	R:R:F125	10.1825	4	1	5
20	R:R:P126	5.9275	4	1	5
21	R:R:W142	6.846	5	3	9
22	R:R:E145	5.495	4	0	7
23	R:R:N149	7.168	5	4	6
24	R:R:F167	12.2925	4	2	3
25	R:R:C168	3.87	4	2	9
26	R:R:Y172	10.8175	4	2	5
27	R:R:L174	6.9425	4	0	3
28	R:R:V184	2.4175	4	0	4
29	R:R:V187	4.7625	4	8	6
30	R:R:P194	2.685	4	0	9
31	R:R:Y202	8.1725	4	0	9
32	R:R:Y238	6.87	4	0	8
33	R:R:Y241	6.39286	7	6	7
34	R:R:R248	10.5975	4	0	5
35	R:R:Y275	9.765	4	6	6
36	R:R:H276	9.0125	4	2	5
37	R:R:N285	9.645	4	1	9
38	R:R:D289	10.57	4	1	9
39	R:R:Y293	6.314	5	1	9
40	R:R:C294	2.235	4	0	6
41	R:R:E303	6	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y76	R:R:Y77	17.4696	6.95	Yes	Yes	2	6	5
2	R:R:C90	R:R:W83	12.4506	9.14	No	Yes	2	9	8
3	R:R:C90	R:R:I158	11.3377	1.64	No	No	2	9	4
4	R:R:I158	R:R:T166	20.4935	3.04	No	No	0	4	5
5	R:R:T166	R:R:V82	15.9321	3.17	No	No	0	5	4
6	R:R:N164	R:R:V82	11.3413	14.78	No	No	0	6	4
7	R:R:C168	R:R:W83	13.6147	5.22	Yes	Yes	2	9	8
8	R:R:C168	R:R:I158	11.3963	1.64	Yes	No	2	9	4
9	R:R:F28	R:R:P71	14.2298	7.22	No	No	0	7	9
10	R:R:P71	R:R:P72	15.3683	5.84	No	No	0	9	6
11	R:R:F93	R:R:P72	16.4995	17.34	No	No	0	5	6
12	R:R:F93	R:R:Y85	20.9511	4.13	No	No	0	5	6
13	R:R:W83	R:R:Y85	22.0457	3.86	Yes	No	0	8	6
14	R:R:F28	R:R:I67	10.7043	8.79	No	Yes	5	7	5
15	R:R:W73	R:R:W83	42.6417	5.62	Yes	Yes	2	6	8
16	R:R:F97	R:R:W73	61.9747	10.02	No	Yes	0	7	6
17	R:R:F97	R:R:L66	22.4374	3.65	No	No	0	7	7
18	R:R:C286	R:R:L66	19.2415	4.76	No	No	0	7	7
19	R:R:C286	R:R:D63	18.1615	10.89	No	No	0	7	9
20	R:R:D63	R:R:N35	17.0742	18.85	No	Yes	0	9	9
21	R:R:N35	R:R:P290	11.528	9.77	Yes	No	0	9	9
22	R:R:A38	R:R:P290	10.3968	1.87	No	No	0	9	9
23	R:R:F97	R:R:Y98	73.8468	6.19	No	No	0	7	5
24	R:R:Y241	R:R:Y98	74.3374	3.97	Yes	No	0	7	5
25	R:R:L101	R:R:Y241	100	3.52	No	Yes	0	7	7
26	R:R:L101	R:R:Y238	99.7328	5.86	No	Yes	0	7	8
27	R:R:N285	R:R:Y238	98.5906	16.28	Yes	Yes	0	9	8
28	R:R:L108	R:R:N285	48.316	4.12	No	Yes	1	8	9
29	R:R:L108	R:R:Y293	47.8218	4.69	No	Yes	1	8	9
30	R:R:R115	R:R:Y293	84.0753	8.23	Yes	Yes	1	9	9
31	R:R:L52	R:R:R115	43.2494	4.86	No	Yes	1	7	9
32	R:R:D114	R:R:L52	42.1072	8.14	Yes	No	1	8	7
33	R:R:D114	R:R:Y55	26.8194	3.45	Yes	Yes	1	8	7
34	R:R:V54	R:R:Y55	23.4478	6.31	No	Yes	1	6	7
35	R:R:V46	R:R:V54	20.1237	1.6	Yes	No	1	5	6
36	R:R:V46	R:R:W43	16.8546	4.9	Yes	No	0	5	3
37	R:R:W40	R:R:W43	13.5159	1.87	No	No	0	3	3
38	R:R:D289	R:R:N285	49.7218	13.46	Yes	Yes	1	9	9
39	R:R:D289	R:R:Y293	48.349	5.75	Yes	Yes	1	9	9
40	R:R:E303	R:R:W40	11.8319	6.54	Yes	No	0	6	3
41	R:R:E145	R:R:Y102	15.2255	3.37	Yes	Yes	0	7	7
42	R:R:L101	R:R:Y102	31.1393	3.52	No	Yes	0	7	7
43	R:R:N149	R:R:Y102	11.6745	8.14	Yes	Yes	4	6	7
44	R:R:R115	R:R:Y202	40.3902	5.14	Yes	Yes	0	9	9
45	R:R:S112	R:R:Y202	28.6316	15.26	No	Yes	0	9	9
46	R:R:C201	R:R:S112	24.1726	5.16	No	No	0	7	9
47	R:R:C201	R:R:Y116	21.5808	6.72	No	Yes	0	7	8
48	R:R:A120	R:R:Y116	10.0747	5.34	No	Yes	7	7	8
49	R:R:R248	R:R:Y172	14.3469	9.26	Yes	Yes	0	5	5
50	R:R:H242	R:R:Y241	18.4764	9.8	No	Yes	0	8	7
51	R:R:H242	R:R:V187	10.8142	4.15	No	Yes	0	8	6
52	R:R:Y241	R:R:Y275	22.7083	11.91	Yes	Yes	6	7	6
53	R:R:R248	R:R:Y275	19.4867	15.43	Yes	Yes	0	5	6
54	R:R:W73	R:R:Y76	18.2457	6.75	Yes	Yes	2	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ZFB

PDB Summary
PDB	8ZFB
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR4
Species	Xenopus tropicalis
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.78
Date	2025-02-26
D.O.I.	10.1016/j.cell.2024.12.001

Net Summary
I_min	3.37
Number of Linked Nodes	256
Number of Links	284
Number of Hubs	41
Number of Links mediated by Hubs	145
Number of Communities	10
Number of Nodes involved in Communities	60
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	47571
Length Of Smallest Path	3
Average Path Length	14.0571
Length of Longest Path	32
Minimum Path Strength	1.12
Average Path Strength	6.86111
Maximum Path Strength	17.305
Minimum Path Correlation	0.7
Average Path Correlation	0.926949
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.3922
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.1092
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	A0A6I8PUB9
Sequence	>8ZFB_Chain_R L D S V L P P S L Y A L V F T L G L P A N L L A L W A A W L Q V R K G R E L G V Y L L N L S L S D L L L I C A L P P W T D Y Y L R R D V W G Y G P G A C R L F G F V F Y T N L Y V G A A F L S C V S A D R Y L A V A H P L R F P G A R P I R S A A A V S A L I W M L E L A A N A P P L L G E A I H R D R Y N H T F C Y E S Y P L S G R G A A L A N V G R V L A G F L L P W G V M M L C Y A G L L R A L R G S A S C E Q R E R R R V R R L A L G L P C V A L L C Y G P Y H A L L L L R S L V F L V G G C A L E E R L F P A Y H A S L A L A T L N C L A D P A L Y C L A C P G A R G E V A K V V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	10.1016/j.cell.2024.12.001
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZFJ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2024-08-07	To be published
	8ZFJ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.1	2024-08-07	To be published
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	10.1016/j.cell.2024.12.001

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZFB.zip

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