Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 4426
2A:A:L45 4.52528
3A:A:L46 2.535408
4A:A:S51 3.2725429
5A:A:K53 4.92529
6A:A:V214 3.485426
7A:A:F219 6.10167628
8A:A:M221 3.5725428
9A:A:F222 8.382517
10A:A:Q227 4.394519
11A:A:K233 5.33667619
12A:A:W234 4.644519
13A:A:F238 6.1719
14A:A:I245 2.7875427
15A:A:F246 4.0225479
16A:A:Y253 8.98408
17A:A:F273 4.97833679
18A:A:W277 7.61833676
19A:A:W281 9.944515
20A:A:I288 4.732529
21A:A:L289 4.0825479
22A:A:F290 4.664529
23A:A:K300 7.28409
24A:A:F312 3.063336138
25A:A:F315 6.1645136
26A:A:Y318 4.6185136
27A:A:E330 7.214573
28A:A:V334 4.4975404
29A:A:K338 7.278575
30A:A:Y339 4.222573
31A:A:F340 9.2225137
32A:A:R342 5.135474
33A:A:F345 7.486578
34A:A:S349 4.4525477
35A:A:C359 3.33475
36A:A:Y360 6.53143728
37A:A:H362 6.2325429
38A:A:F363 5.71575
39A:A:T364 5.306529
40A:A:N371 5.252529
41A:A:R374 5.136524
42A:A:I375 2.9125429
43A:A:F376 4.24628
44A:A:K380 3.795427
45A:A:I383 3.345408
46A:A:L388 3.224178
47A:A:Y391 4.81571754
48B:B:V40 4.872593
49B:B:R48 5.5075407
50B:B:H54 7.84639
51B:B:K57 7.164519
52B:B:Y59 5.6025418
53B:B:M61 3.325436
54B:B:W63 4.85286737
55B:B:V71 3.63408
56B:B:S72 6.0025439
57B:B:Q75 7.655419
58B:B:D76 4.9456159
59B:B:W82 8.10667639
60B:B:D83 8.445438
61B:B:T86 5.775436
62B:B:K89 6.95833639
63B:B:I93 3.7407
64B:B:W99 7.51619
65B:B:M101 3.54419
66B:B:Y105 4.468336186
67B:B:S108 3.845406
68B:B:Y111 4.935404
69B:B:C114 3.154148
70B:B:G115 1.9409
71B:B:L117 3.048519
72B:B:C121 2.4925408
73B:B:Y124 3.775146
74B:B:L126 3.5945185
75B:B:L139 4.9775419
76B:B:H142 6.306519
77B:B:Y145 3.95222918
78B:B:R150 5.3825466
79B:B:F151 4.4075409
80B:B:L152 3.928503
81B:B:S160 2.586566
82B:B:S161 7.805419
83B:B:D163 9.2575419
84B:B:C166 3.05568
85B:B:W169 8.542518
86B:B:F180 6.656567
87B:B:H183 6.83571769
88B:B:V187 3.08469
89B:B:L190 3.122565
90B:B:F199 4.84286769
91B:B:V200 5.23446
92B:B:S201 4.6075469
93B:B:C204 5.6575417
94B:B:D205 6.44469
95B:B:K209 9.905466
96B:B:W211 6.85167668
97B:B:F222 5.914548
98B:B:H225 7.24857749
99B:B:D228 8.17419
100B:B:I232 3.87548
101B:B:F234 3.9975405
102B:B:F235 6.82429796
103B:B:P236 7.0875497
104B:B:F241 5.86333646
105B:B:T243 4.402548
106B:B:S245 6.9725449
107B:B:D246 2.8575409
108B:B:D247 6.4975449
109B:B:C250 3.482548
110B:B:R251 8.006548
111B:B:F253 5.65646
112B:B:L255 3.475446
113B:B:D258 8.57447
114B:B:M262 4.2325444
115B:B:Y264 4.885645
116B:B:T274 3.31418
117B:B:V276 2.4475406
118B:B:F278 4.035697
119B:B:G282 2.7225499
120B:B:R283 8.34599
121B:B:G288 2.82417
122B:B:Y289 5.16667647
123B:B:D290 6.646516
124B:B:N295 6.0625446
125B:B:W297 6.5125448
126B:B:L300 4.86496
127B:B:H311 9.418519
128B:B:R314 12.564518
129B:B:T321 5.6225437
130B:B:M325 3.88571735
131B:B:W332 8.23667619
132B:B:D333 6.2225419
133B:B:L336 3.05537
134B:B:K337 6.812516
135B:B:I338 3.6825435
136B:B:W339 7.13519
137G:G:Y40 7.795496
138G:G:D48 5.52833609
139G:G:N59 7.136539
140G:G:P60 5.985439
141G:G:F61 4.12738
142R:R:C9 3.7054118
143R:R:V11 4.47254113
144R:R:Y24 3.624509
145R:R:I28 2.6675407
146R:R:G31 2.275408
147R:R:L32 3.7025406
148R:R:N50 4.2025457
149R:R:E51 4.87457
150R:R:L52 3.546558
151R:R:G53 2.5925457
152R:R:Y55 4.6975407
153R:R:L56 3.14458
154R:R:L59 3.98459
155R:R:D63 3.8575459
156R:R:Y66 5.665407
157R:R:I67 4.1325406
158R:R:L70 3.28408
159R:R:W73 5.0025107
160R:R:Y76 7.823336106
161R:R:W83 7.0485109
162R:R:F93 4.53754106
163R:R:F95 6.8554216
164R:R:F97 8.4275407
165R:R:F107 4.69333658
166R:R:D114 5.51458
167R:R:R115 4.065459
168R:R:Y116 4.634128
169R:R:H121 4.79254126
170R:R:L123 3.38426
171R:R:F125 5.36254126
172R:R:R129 4.725457
173R:R:W142 4.525659
174R:R:F159 7.4125402
175R:R:R162 6.88584
176R:R:F167 6.5175401
177R:R:F169 5.626504
178R:R:F172 4.395115
179R:R:M174 3.506581
180R:R:W177 5.3975481
181R:R:V178 6.71482
182R:R:N182 4.684585
183R:R:R185 5.25485
184R:R:F190 7.9175408
185R:R:Y201 5.172508
186R:R:L229 3.1725408
187R:R:F237 6.938558
188R:R:Y240 6.30333686
189R:R:R247 6.91833684
190R:R:D282 7.214559
191R:R:Y286 4.02659
192R:R:C287 1.73408
193R:R:N290 4.5175408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F219 A:A:H41 17.79357.92YesYes286
2A:A:F219 A:A:L43 18.06372.44YesNo287
3A:A:I245 A:A:L43 18.07592.85YesNo277
4A:A:I245 A:A:L45 62.59182.85YesYes278
5A:A:K53 A:A:L45 80.65818.46YesYes298
6A:A:G47 A:A:K53 89.59161.74NoYes299
7A:A:G47 A:A:L46 1001.71NoYes098
8A:A:L44 A:A:L46 98.55994.15NoYes098
9A:A:F238 A:A:L44 98.529217.05YesNo099
10A:A:F212 A:A:F219 18.10712.86NoYes098
11A:A:F212 A:A:M221 18.14482.49NoYes098
12A:A:L45 A:A:M221 18.15294.24YesYes288
13A:A:F238 B:B:W99 27.178110.02YesYes199
14A:A:H41 R:R:L123 17.70792.57YesYes266
15A:A:F219 A:A:F376 18.17745.36YesYes288
16A:A:F376 R:R:L123 17.72712.44YesYes286
17A:A:I245 A:A:I375 17.75972.94YesYes279
18A:A:G47 A:A:S51 10.4371.86NoYes299
19A:A:F290 A:A:I245 26.77552.51YesYes297
20A:A:N292 A:A:T364 18.80112.92NoYes099
21A:A:N292 A:A:V247 18.84958.87NoNo097
22A:A:F238 A:A:W234 23.89982YesYes199
23A:A:W281 B:B:W332 20.06463.75YesYes159
24A:A:W281 B:B:D290 19.56186.7YesYes156
25B:B:R314 B:B:W332 29.208918.99YesYes189
26B:B:D290 B:B:R314 19.555214.29YesYes168
27A:A:C237 A:A:F238 43.46242.79NoYes189
28A:A:C237 B:B:Q75 19.82733.05NoYes189
29B:B:Q75 B:B:W99 19.93116.57YesYes199
30B:B:K57 B:B:W332 59.177410.44YesYes199
31B:B:K57 B:B:Y59 20.02684.78YesYes198
32A:A:F290 A:A:I288 17.71965.02YesYes299
33A:A:I288 A:A:I375 17.73472.94YesYes299
34A:A:R374 A:A:T364 18.31143.88YesYes249
35A:A:H362 A:A:R374 27.139111.28YesYes294
36A:A:H362 A:A:Y360 44.692.18YesYes298
37A:A:H362 A:A:I288 17.68092.65YesYes299
38A:A:D378 A:A:I288 17.68339.8NoYes279
39A:A:D378 A:A:Y360 17.633213.79NoYes278
40A:A:D381 A:A:Y360 60.46023.45NoYes088
41A:A:D381 R:R:S211 60.09294.42NoNo085
42A:A:I383 R:R:L123 35.34354.28YesYes086
43A:A:I383 A:A:N387 35.0784.25YesNo088
44A:A:L384 R:R:S211 59.55513NoNo065
45A:A:L384 A:A:L388 58.99622.77NoYes1768
46A:A:N387 R:R:R129 34.97372.41NoYes087
47A:A:L388 A:A:L393 58.46044.15YesNo088
48A:A:Y391 R:R:R129 32.5615.14YesYes547
49A:A:Y391 R:R:L52 30.27352.34YesYes548
50A:A:L393 R:R:R115 56.27432.43NoYes089
51B:B:F235 B:B:F278 14.16469.65YesYes967
52B:B:F278 B:B:L285 10.52183.65YesNo076
53B:B:F278 B:B:L252 10.25512.44YesNo077
54B:B:L252 B:B:Y264 12.62172.34NoYes075
55B:B:L285 B:B:Y264 10.61993.52NoYes065
56B:B:G115 B:B:G116 11.32732.11YesNo099
57B:B:G116 B:B:M101 11.50451.75NoYes099
58B:B:W297 B:B:Y264 28.59810.61YesYes485
59B:B:W297 B:B:Y289 29.36575.79YesYes487
60B:B:C271 B:B:D290 45.54116.22NoYes056
61B:B:C271 B:B:D291 45.14256.22NoNo058
62B:B:D291 B:B:Y289 44.34724.6NoYes087
63R:R:R115 R:R:Y286 50.09724.12YesYes599
64R:R:D282 R:R:Y286 66.27662.3YesYes599
65R:R:D282 R:R:N278 32.43813.46YesNo599
66R:R:F237 R:R:N278 31.843210.87YesNo589
67R:R:F237 R:R:T275 24.20217.78YesNo088
68R:R:T275 R:R:Y240 23.90883.75NoYes086
69R:R:L52 R:R:L56 28.74132.77YesYes588
70R:R:L56 R:R:Y286 28.5713.52YesYes589
71R:R:D282 R:R:D63 24.48692.66YesYes599
72R:R:C279 R:R:D63 20.0634.67NoYes099
73R:R:C279 R:R:I67 19.76833.27NoYes096
74R:R:I28 R:R:I67 16.26352.94YesYes076
75R:R:I28 R:R:L70 15.38544.28YesYes078
76R:R:F107 R:R:L59 17.7113.65YesYes589
77R:R:F107 R:R:W142 13.5717.02YesYes589
78R:R:L146 R:R:W142 12.3992.28NoYes039
79A:A:C237 B:B:Y59 23.59162.69NoYes188
80B:B:K57 B:B:Q75 39.649610.85YesYes199
81A:A:W234 B:B:Y145 23.63271.93YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9JFZ
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.9
Date 2025-04-23
D.O.I. doi.org/10.1038/s41422-025-01092-w
Net Summary
Imin 1.71
Number of Linked Nodes 859
Number of Links 1115
Number of Hubs 193
Number of Links mediated by Hubs 696
Number of Communities 24
Number of Nodes involved in Communities 294
Number of Links involved in Communities 448
Path Summary
Number Of Nodes in MetaPath 82
Number Of Links MetaPath 81
Number of Shortest Paths 7508843
Length Of Smallest Path 3
Average Path Length 34.2964
Length of Longest Path 52
Minimum Path Strength 1.35
Average Path Strength 5.12053
Maximum Path Strength 17.99
Minimum Path Correlation 0.71
Average Path Correlation 0.99629
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 35.7682
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.6748
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • synapse   • cell junction   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • Ras protein signal transduction   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9JFZ_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGASGKST 
IVKQMRILS GIFETKFQV DKVNFHMFD VGGQRDERR KWIQCFNDV 
TAIIFVVSS YNRLQEALN LFKSIWNNR WLRTISVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD 
EFLRISTAS GDGRHYCYP HFTCAVDTE NRRFNDCDI IMLRYLDND 
DAIKLQNEN V


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JFZ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JFZ_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JFZ_Chain_R
GCHVDSRVD HLFPPSLYI VIGVGLPTN CLALWAAYR QVQQRNELG 
YLMLSIADL YICTLPWVD YFHHDNWIH GPGSCKLFF IFYTNIYIS 
IAFLCCIVD RYLAVAHPL RFRLRRVTV AVSSVVWAT ELGANSAPL 
FHDELFRDR YNHTCFEKF PMEGWVAWM NLYRFVGFF PWAMLSYRL 
RVRGSVSTE RQEKAKIKL ALSLAIVLV CFAPYHVLL SRSAIYGRP 
WDCGFEERV FSAYHSSAF TSLNCVDPI YLVNEGARS DAKAFVNLL 
LGSAKAFVL LLGIARILL LALCV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JFZ.zip



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