psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D161	R:R:G8	5.03	No	No	5	2	5
2	R:R:G8	R:R:P173	4.06	No	No	5	5	4
3	R:R:C258	R:R:C9	7.28	No	No	0	8	8
4	R:R:H10	R:R:Y163	15.24	No	No	0	3	3
5	R:R:E262	R:R:H10	6.15	No	No	0	3	3
6	R:R:E261	R:R:V11	8.56	Yes	No	0	4	3
7	R:R:F265	R:R:V11	7.87	Yes	No	0	4	3
8	R:R:D16	R:R:S13	5.89	Yes	No	1	5	5
9	R:R:F265	R:R:S13	5.28	Yes	No	1	4	5
10	R:R:S13	R:R:S266	6.52	No	No	0	5	2
11	R:R:D16	R:R:F265	14.33	Yes	Yes	1	5	4
12	R:R:D16	R:R:H269	13.87	Yes	Yes	1	5	5
13	R:R:H17	R:R:H80	14.33	No	No	0	5	4
14	R:R:F19	R:R:P20	4.33	No	Yes	0	5	5
15	R:R:F19	R:R:L23	7.31	No	No	0	5	5
16	R:R:P20	R:R:P21	7.79	Yes	No	0	5	7
17	R:R:L23	R:R:L277	6.92	No	No	0	5	5
18	R:R:L70	R:R:Y24	9.38	Yes	Yes	0	8	9
19	R:R:F77	R:R:Y24	6.19	No	Yes	0	5	9
20	R:R:F97	R:R:Y24	5.16	Yes	Yes	0	7	9
21	R:R:S276	R:R:Y24	6.36	No	Yes	0	7	9
22	R:R:F26	R:R:V30	5.24	No	No	0	4	6
23	R:R:S276	R:R:V27	4.85	No	No	0	7	7
24	R:R:I28	R:R:L70	4.28	No	Yes	0	7	8
25	R:R:I67	R:R:L32	8.56	No	No	0	6	6
26	R:R:P283	R:R:T34	6.99	No	No	0	9	7
27	R:R:D63	R:R:N35	6.73	Yes	Yes	0	9	9
28	R:R:I67	R:R:N35	5.66	No	Yes	0	6	9
29	R:R:N35	R:R:P283	13.03	Yes	No	0	9	9
30	R:R:L39	R:R:M57	4.24	No	No	0	7	5
31	R:R:L39	R:R:S60	9.01	No	No	0	7	8
32	R:R:R44	R:R:W40	4	Yes	No	0	4	4
33	R:R:A300	R:R:W40	7.78	No	No	0	3	4
34	R:R:A41	R:R:D296	4.63	No	Yes	0	7	4
35	R:R:Q47	R:R:R44	4.67	No	Yes	0	6	4
36	R:R:D296	R:R:R44	7.15	Yes	Yes	0	4	4
37	R:R:K299	R:R:R44	7.43	No	Yes	0	5	4
38	R:R:N50	R:R:Q45	15.85	No	No	0	7	5
39	R:R:R49	R:R:V131	6.54	No	No	0	6	3
40	R:R:L52	R:R:N50	4.12	Yes	No	0	8	7
41	R:R:E51	R:R:R129	9.3	No	No	0	7	7
42	R:R:L52	R:R:L56	4.15	Yes	No	0	8	8
43	R:R:I111	R:R:L52	4.28	No	Yes	0	9	8
44	R:R:D114	R:R:L52	6.79	No	Yes	0	8	8
45	R:R:A134	R:R:V54	5.09	No	Yes	0	5	5
46	R:R:S138	R:R:V54	4.85	No	Yes	0	7	5
47	R:R:C110	R:R:Y55	5.38	No	Yes	0	7	7
48	R:R:D114	R:R:Y55	6.9	No	Yes	0	8	7
49	R:R:A134	R:R:Y55	5.34	No	Yes	0	5	7
50	R:R:V137	R:R:Y55	8.83	No	Yes	0	5	7
51	R:R:F107	R:R:N58	9.67	Yes	No	4	8	7
52	R:R:N58	R:R:S138	10.43	No	No	0	7	7
53	R:R:N58	R:R:W142	6.78	No	Yes	4	7	9
54	R:R:D63	R:R:L59	4.07	Yes	Yes	2	9	9
55	R:R:L59	R:R:S104	4.5	Yes	No	2	9	9
56	R:R:L108	R:R:L59	5.54	Yes	Yes	2	8	9
57	R:R:D282	R:R:L59	6.79	No	Yes	2	9	9
58	R:R:I61	R:R:W142	8.22	No	Yes	0	5	9
59	R:R:D63	R:R:S104	5.89	Yes	No	2	9	9
60	R:R:C279	R:R:D63	6.22	No	Yes	0	9	9
61	R:R:L65	R:R:N100	6.87	No	No	0	7	8
62	R:R:L70	R:R:Y66	9.38	Yes	Yes	0	8	7
63	R:R:F97	R:R:Y66	9.28	Yes	Yes	0	7	7
64	R:R:N100	R:R:Y66	5.81	No	Yes	0	8	7
65	R:R:I101	R:R:Y66	4.84	No	Yes	0	8	7
66	R:R:S276	R:R:Y66	7.63	No	Yes	0	7	7
67	R:R:I96	R:R:T69	12.16	No	No	0	5	7
68	R:R:L72	R:R:W83	5.69	No	Yes	7	7	9
69	R:R:H85	R:R:L72	10.29	Yes	No	7	7	7
70	R:R:F93	R:R:L72	9.74	No	No	0	6	7
71	R:R:W73	R:R:Y76	12.54	Yes	Yes	0	7	6
72	R:R:G94	R:R:W73	4.22	No	Yes	0	8	7
73	R:R:F97	R:R:W73	33.07	Yes	Yes	0	7	7
74	R:R:C168	R:R:W73	6.53	No	Yes	0	9	7
75	R:R:F77	R:R:Y76	10.32	No	Yes	0	5	6
76	R:R:D81	R:R:Y76	4.6	No	Yes	0	4	6
77	R:R:W83	R:R:Y76	4.82	Yes	Yes	0	9	6
78	R:R:E170	R:R:Y76	6.73	Yes	Yes	0	4	6
79	R:R:F77	R:R:H269	16.97	No	Yes	0	5	5
80	R:R:D81	R:R:F265	11.94	No	Yes	1	4	4
81	R:R:D81	R:R:H269	6.3	No	Yes	1	4	5
82	R:R:N164	R:R:N82	5.45	No	Yes	0	4	5
83	R:R:H165	R:R:N82	6.38	Yes	Yes	0	1	5
84	R:R:N82	R:R:T166	7.31	Yes	No	0	5	3
85	R:R:H85	R:R:W83	5.29	Yes	Yes	7	7	9
86	R:R:C168	R:R:W83	18.28	No	Yes	0	9	9
87	R:R:H85	R:R:I84	6.63	Yes	No	0	7	3
88	R:R:H85	R:R:S89	8.37	Yes	No	0	7	6
89	R:R:G86	R:R:P87	4.06	No	No	0	8	3
90	R:R:L158	R:R:P87	4.93	No	No	0	5	3
91	R:R:C168	R:R:C90	5.46	No	No	0	9	9
92	R:R:E157	R:R:K91	16.2	No	No	0	5	6
93	R:R:F93	R:R:L92	6.09	No	No	0	6	5
94	R:R:I96	R:R:L92	4.28	No	No	0	5	5
95	R:R:F169	R:R:G94	4.52	Yes	No	0	4	8
96	R:R:F95	R:R:T99	5.19	No	No	0	6	5
97	R:R:F95	R:R:L153	12.18	No	No	0	6	4
98	R:R:F97	R:R:Y98	8.25	Yes	Yes	0	7	5
99	R:R:F169	R:R:Y98	16.5	Yes	Yes	0	4	5
100	R:R:E170	R:R:Y98	6.73	Yes	Yes	0	4	5
101	R:R:R185	R:R:Y98	12.35	Yes	Yes	0	5	5
102	R:R:N149	R:R:T99	10.24	Yes	No	0	7	5
103	R:R:I101	R:R:Y102	9.67	No	Yes	0	8	7
104	R:R:R185	R:R:Y102	18.52	Yes	Yes	0	5	7
105	R:R:H241	R:R:Y102	4.36	Yes	Yes	0	8	7
106	R:R:F107	R:R:I103	7.54	Yes	Yes	4	8	7
107	R:R:I103	R:R:W142	8.22	Yes	Yes	4	7	9
108	R:R:E145	R:R:I103	6.83	No	Yes	0	7	7
109	R:R:I105	R:R:P193	5.08	No	No	0	8	9
110	R:R:F237	R:R:I105	7.54	Yes	No	0	8	8
111	R:R:F107	R:R:V141	6.55	Yes	No	0	8	7
112	R:R:F107	R:R:W142	11.02	Yes	Yes	4	8	9
113	R:R:L108	R:R:M197	5.65	Yes	No	0	8	7
114	R:R:D282	R:R:L108	12.21	No	Yes	2	9	8
115	R:R:L108	R:R:Y286	11.72	Yes	Yes	2	8	9
116	R:R:C109	R:R:L196	4.76	No	No	0	8	4
117	R:R:I111	R:R:Y286	6.04	No	Yes	0	9	9
118	R:R:M197	R:R:S112	4.6	No	No	0	7	9
119	R:R:S112	R:R:S200	6.52	No	No	0	9	8
120	R:R:R115	R:R:Y201	11.32	No	Yes	2	9	8
121	R:R:R115	R:R:Y286	5.14	No	Yes	2	9	9
122	R:R:A120	R:R:Y116	9.34	No	No	3	7	8
123	R:R:H121	R:R:Y116	5.44	Yes	No	3	6	8
124	R:R:A118	R:R:R129	4.15	No	No	0	8	7
125	R:R:A120	R:R:H121	7.32	No	Yes	3	7	6
126	R:R:H121	R:R:R124	14.67	Yes	No	3	6	4
127	R:R:F125	R:R:H121	6.79	Yes	Yes	3	6	6
128	R:R:F125	R:R:R124	14.97	Yes	No	3	6	4
129	R:R:E145	R:R:N149	5.26	No	Yes	0	7	7
130	R:R:M181	R:R:N149	4.21	No	Yes	0	4	7
131	R:R:N149	R:R:Y184	8.14	Yes	No	0	7	3
132	R:R:F169	R:R:P152	7.22	Yes	Yes	0	4	3
133	R:R:P152	R:R:W177	6.76	Yes	Yes	0	3	1
134	R:R:M181	R:R:P152	6.71	No	Yes	0	4	3
135	R:R:H155	R:R:W177	21.16	No	Yes	0	4	1
136	R:R:E157	R:R:F169	13.99	No	Yes	0	5	4
137	R:R:F159	R:R:K171	16.13	No	No	0	2	3
138	R:R:R160	R:R:R162	4.26	No	No	0	1	4
139	R:R:D161	R:R:Y163	6.9	No	No	0	2	3
140	R:R:D161	R:R:P173	6.44	No	No	5	2	4
141	R:R:F167	R:R:H165	4.53	No	Yes	0	1	1
142	R:R:F167	R:R:F172	13.93	No	Yes	0	1	5
143	R:R:E170	R:R:F172	4.66	Yes	Yes	1	4	5
144	R:R:E170	R:R:Y268	5.61	Yes	Yes	1	4	5
145	R:R:E170	R:R:H269	9.85	Yes	Yes	1	4	5
146	R:R:K171	R:R:P173	13.38	No	No	0	3	4
147	R:R:E175	R:R:K171	8.1	No	No	0	2	3
148	R:R:E261	R:R:F172	13.99	Yes	Yes	0	4	5
149	R:R:F172	R:R:F265	9.65	Yes	Yes	1	5	4
150	R:R:F172	R:R:Y268	4.13	Yes	Yes	1	5	5
151	R:R:F172	R:R:H269	9.05	Yes	Yes	1	5	5
152	R:R:M174	R:R:R247	6.2	No	No	0	1	4
153	R:R:M174	R:R:Y251	7.18	No	Yes	0	1	3
154	R:R:E175	R:R:W177	4.36	No	Yes	0	2	1
155	R:R:G176	R:R:Y251	5.79	No	Yes	0	4	3
156	R:R:V178	R:R:W177	11.03	No	Yes	0	2	1
157	R:R:L252	R:R:W180	6.83	No	No	0	6	3
158	R:R:M181	R:R:R185	13.65	No	Yes	0	4	5
159	R:R:N182	R:R:R185	7.23	No	Yes	0	5	5
160	R:R:L244	R:R:N182	5.49	No	No	0	5	5
161	R:R:N182	R:R:S248	4.47	No	No	0	5	5
162	R:R:V188	R:R:Y184	5.05	No	No	0	4	3
163	R:R:H241	R:R:V186	6.92	Yes	No	0	8	4
164	R:R:F190	R:R:F237	7.5	No	Yes	8	8	8
165	R:R:F190	R:R:H241	27.15	No	Yes	8	8	8
166	R:R:F192	R:R:P193	5.78	No	No	0	5	9
167	R:R:F192	R:R:L196	10.96	No	No	0	5	4
168	R:R:I230	R:R:W194	4.7	No	No	0	7	6
169	R:R:V233	R:R:W194	7.36	No	No	0	9	6
170	R:R:L234	R:R:W194	21.64	No	No	0	6	6
171	R:R:M197	R:R:V233	4.56	No	No	0	7	9
172	R:R:I230	R:R:L198	5.71	No	No	0	7	5
173	R:R:A226	R:R:Y201	4	No	Yes	0	7	8
174	R:R:L229	R:R:Y201	11.72	Yes	Yes	2	8	8
175	R:R:I230	R:R:Y201	7.25	No	Yes	0	7	8
176	R:R:Y201	R:R:Y286	4.96	Yes	Yes	2	8	9
177	R:R:G203	R:R:R202	4.5	No	No	0	3	3
178	R:R:K223	R:R:L205	8.46	No	No	0	6	5
179	R:R:A226	R:R:L205	4.73	No	No	0	7	5
180	R:R:R206	R:R:R209	4.26	No	No	0	3	4
181	R:R:I222	R:R:V208	13.83	No	No	0	7	8
182	R:R:S211	R:R:T214	9.59	No	No	0	5	3
183	R:R:K219	R:R:T214	10.51	No	No	0	6	3
184	R:R:E215	R:R:E218	12.69	No	No	0	3	5
185	R:R:A220	R:R:R224	5.53	No	No	0	5	3
186	R:R:E291	R:R:K221	5.4	No	No	0	5	7
187	R:R:L285	R:R:S228	7.51	No	No	0	5	6
188	R:R:L229	R:R:L285	5.54	Yes	No	0	8	5
189	R:R:L229	R:R:Y286	8.21	Yes	Yes	2	8	9
190	R:R:N278	R:R:V233	4.43	No	No	0	9	9
191	R:R:F237	R:R:H241	5.66	Yes	Yes	8	8	8
192	R:R:F237	R:R:T275	7.78	Yes	No	0	8	8
193	R:R:F237	R:R:N278	10.87	Yes	No	0	8	9
194	R:R:L244	R:R:Y240	17.58	No	Yes	1	5	6
195	R:R:Y240	R:R:Y268	9.93	Yes	Yes	1	6	5
196	R:R:L272	R:R:Y240	19.93	No	Yes	0	5	6
197	R:R:T275	R:R:Y240	7.49	No	Yes	0	8	6
198	R:R:L243	R:R:S271	4.5	No	No	0	6	7
199	R:R:L244	R:R:Y268	4.69	No	Yes	1	5	5
200	R:R:E261	R:R:R247	13.96	Yes	No	0	4	4
201	R:R:R247	R:R:Y268	21.61	No	Yes	0	4	5
202	R:R:P255	R:R:Y251	9.74	No	Yes	0	2	3
203	R:R:R254	R:R:W256	4	No	No	0	2	3
204	R:R:D257	R:R:R254	10.72	No	No	0	5	2
205	R:R:F260	R:R:R263	10.69	No	No	0	1	3
206	R:R:F260	R:R:V264	14.42	No	No	0	1	4
207	R:R:E261	R:R:V264	4.28	Yes	No	0	4	4
208	R:R:F265	R:R:H269	12.44	Yes	Yes	1	4	5
209	R:R:H269	R:R:Y268	6.53	Yes	Yes	1	5	5
210	R:R:D282	R:R:N278	13.46	No	No	0	9	9
211	R:R:I284	R:R:L288	7.14	No	No	0	7	7
212	R:R:N290	R:R:V289	4.43	No	No	0	8	6
213	R:R:F187	R:R:V186	3.93	No	No	0	5	4
214	R:R:H17	R:R:L78	3.86	No	No	0	5	7
215	R:R:Q45	R:R:Q48	3.84	No	No	0	5	7
216	R:R:E215	R:R:Q217	3.82	No	No	0	3	4
217	R:R:V74	R:R:Y24	3.79	No	Yes	0	7	9
218	R:R:D12	R:R:H165	3.78	No	Yes	0	6	1
219	R:R:I204	R:R:R115	3.76	No	No	0	6	9
220	R:R:A273	R:R:P20	3.74	No	Yes	0	5	5
221	R:R:G147	R:R:S150	3.71	No	No	0	4	4
222	R:R:G292	R:R:S295	3.71	No	No	0	6	4
223	R:R:G31	R:R:V280	3.68	No	No	0	8	8
224	R:R:F125	R:R:L128	3.65	Yes	No	0	6	3
225	R:R:F190	R:R:L191	3.65	No	No	0	8	4
226	R:R:G31	R:R:T34	3.64	No	No	0	8	7
227	R:R:L199	R:R:R202	3.64	No	No	0	4	3
228	R:R:A41	R:R:C287	3.61	No	No	0	7	8
229	R:R:A293	R:R:C287	3.61	No	No	0	8	8
230	R:R:P239	R:R:S271	3.56	No	No	0	9	7
231	R:R:C9	R:R:V11	3.42	No	No	0	8	3
232	R:R:L32	R:R:P33	3.28	No	No	0	6	5
233	R:R:C236	R:R:I232	3.27	No	No	0	8	7
234	R:R:A62	R:R:I103	3.25	No	Yes	0	8	7
235	R:R:A281	R:R:I232	3.25	No	No	0	5	7
236	R:R:S266	R:R:V15	3.23	No	No	0	2	4
237	R:R:S200	R:R:V113	3.23	No	No	0	8	6
238	R:R:D16	R:R:P20	3.22	Yes	Yes	0	5	5
239	R:R:V280	R:R:V30	3.21	No	No	0	8	6
240	R:R:V135	R:R:V54	3.21	No	Yes	6	4	5
241	R:R:C90	R:R:L158	3.17	No	No	0	9	5
242	R:R:C236	R:R:L277	3.17	No	No	0	8	5
243	R:R:A238	R:R:L234	3.15	No	No	0	5	6
244	R:R:A293	R:R:N290	3.13	No	No	0	8	8
245	R:R:I284	R:R:T34	3.04	No	No	0	7	7
246	R:R:K219	R:R:V208	3.04	No	No	0	6	8
247	R:R:L153	R:R:S150	3	No	No	0	4	4
248	R:R:L243	R:R:S246	3	No	No	0	6	4
249	R:R:L37	R:R:V297	2.98	No	No	0	7	7
250	R:R:L117	R:R:V113	2.98	No	No	0	6	6
251	R:R:L225	R:R:V289	2.98	No	No	0	8	6
252	R:R:D75	R:R:V74	2.92	No	No	0	4	7
253	R:R:D296	R:R:V297	2.92	Yes	No	0	4	7
254	R:R:G189	R:R:Y102	2.9	No	Yes	0	6	7
255	R:R:G203	R:R:Y116	2.9	No	No	0	3	8
256	R:R:I222	R:R:L205	2.85	No	No	0	7	5
257	R:R:K223	R:R:L227	2.82	No	No	0	6	5
258	R:R:L225	R:R:L229	2.77	No	Yes	0	8	8
259	R:R:L64	R:R:N35	2.75	No	Yes	0	8	9
260	R:R:A148	R:R:Y184	2.67	No	No	0	5	3
261	R:R:A179	R:R:Y251	2.67	No	Yes	0	1	3
262	R:R:F19	R:R:S270	2.64	No	No	0	5	5
263	R:R:E51	R:R:N50	2.63	No	No	0	7	7
264	R:R:F274	R:R:V235	2.62	No	No	0	7	5
265	R:R:R130	R:R:T133	2.59	No	No	0	6	3
266	R:R:F95	R:R:L146	2.44	No	No	0	6	3
267	R:R:F125	R:R:L117	2.44	Yes	No	0	6	6
268	R:R:F187	R:R:L245	2.44	No	No	0	5	6
269	R:R:F274	R:R:L277	2.44	No	No	0	7	5
270	R:R:E291	R:R:R294	2.33	No	No	0	5	8
271	R:R:F154	R:R:H155	2.26	No	No	0	4	4
272	R:R:Q47	R:R:Y43	2.25	No	No	0	6	4
273	R:R:R127	R:R:R130	2.13	No	No	0	4	6
274	R:R:R162	R:R:Y163	2.06	No	No	0	4	3
275	R:R:C9	R:R:G259	1.96	No	No	0	8	2
276	R:R:A42	R:R:G53	1.95	No	No	0	7	7
277	R:R:A38	R:R:P283	1.87	No	No	0	9	9
278	R:R:A151	R:R:P152	1.87	No	Yes	0	7	3
279	R:R:A238	R:R:P239	1.87	No	No	0	5	9
280	R:R:G53	R:R:V46	1.84	No	No	0	7	6
281	R:R:G29	R:R:I28	1.76	No	No	0	5	7
282	R:R:G88	R:R:K91	1.74	No	No	0	2	6
283	R:R:A106	R:R:V141	1.7	No	No	0	6	7
284	R:R:A207	R:R:V119	1.7	No	No	0	3	8
285	R:R:A267	R:R:V264	1.7	No	No	0	5	4
286	R:R:E7	R:R:G8	1.64	No	No	0	4	5
287	R:R:G53	R:R:Q45	1.64	No	No	0	7	5
288	R:R:L70	R:R:P71	1.64	Yes	No	0	8	8
289	R:R:L123	R:R:P122	1.64	No	No	0	6	7
290	R:R:E291	R:R:G292	1.64	No	No	0	5	6
291	R:R:S211	R:R:S213	1.63	No	No	0	5	3
292	R:R:S139	R:R:V140	1.62	No	No	0	5	3
293	R:R:A42	R:R:M57	1.61	No	No	0	7	5
294	R:R:V131	R:R:V54	1.6	No	Yes	6	3	5
295	R:R:V131	R:R:V135	1.6	No	No	6	3	4
296	R:R:T133	R:R:V137	1.59	No	No	0	3	5
297	R:R:T144	R:R:V140	1.59	No	No	0	5	3
298	R:R:I25	R:R:V74	1.54	No	No	0	4	7
299	R:R:H121	R:R:P122	1.53	Yes	No	0	6	7
300	R:R:L18	R:R:S22	1.5	No	No	0	4	5
301	R:R:K132	R:R:T133	1.5	No	No	0	4	3
302	R:R:G203	R:R:R206	1.5	No	No	0	3	3
303	R:R:G210	R:R:R209	1.5	No	No	0	4	4
304	R:R:D296	R:R:S295	1.47	Yes	No	0	4	4
305	R:R:P255	R:R:R254	1.44	No	No	0	2	2
306	R:R:G176	R:R:W180	1.41	No	No	0	4	3
307	R:R:E218	R:R:T214	1.41	No	No	0	5	3
308	R:R:L183	R:R:L245	1.38	No	No	0	4	6
309	R:R:H79	R:R:N82	1.28	No	Yes	0	4	5
310	R:R:K221	R:R:R224	1.24	No	No	0	7	3
311	R:R:H165	R:R:H80	1.19	Yes	No	0	1	4
312	R:R:Q217	R:R:R216	1.17	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D16	9.3275	4	1	5
2	R:R:P20	4.77	4	0	5
3	R:R:Y24	6.176	5	0	9
4	R:R:N35	7.0425	4	0	9
5	R:R:R44	5.8125	4	0	4
6	R:R:L52	4.835	4	0	8
7	R:R:V54	3.6875	4	6	5
8	R:R:Y55	6.6125	4	0	7
9	R:R:L59	5.225	4	2	9
10	R:R:D63	5.7275	4	2	9
11	R:R:Y66	7.388	5	0	7
12	R:R:L70	6.17	4	0	8
13	R:R:W73	14.09	4	0	7
14	R:R:Y76	7.802	5	0	6
15	R:R:N82	5.105	4	0	5
16	R:R:W83	8.52	4	7	9
17	R:R:H85	7.645	4	7	7
18	R:R:F97	13.94	4	0	7
19	R:R:Y98	10.9575	4	0	5
20	R:R:Y102	8.8625	4	0	7
21	R:R:I103	6.46	4	4	7
22	R:R:F107	8.695	4	4	8
23	R:R:L108	8.78	4	2	8
24	R:R:H121	7.15	5	3	6
25	R:R:F125	6.9625	4	3	6
26	R:R:W142	8.56	4	4	9
27	R:R:N149	6.9625	4	0	7
28	R:R:P152	5.64	4	0	3
29	R:R:H165	3.97	4	0	1
30	R:R:F169	10.5575	4	0	4
31	R:R:E170	6.716	5	1	4
32	R:R:F172	9.235	6	1	5
33	R:R:W177	10.8275	4	0	1
34	R:R:R185	12.9375	4	0	5
35	R:R:Y201	7.85	5	2	8
36	R:R:L229	7.06	4	2	8
37	R:R:F237	7.87	5	8	8
38	R:R:Y240	13.7325	4	1	6
39	R:R:H241	11.0225	4	8	8
40	R:R:Y251	6.345	4	0	3
41	R:R:E261	10.1975	4	0	4
42	R:R:F265	10.2517	6	1	4
43	R:R:Y268	8.75	6	1	5
44	R:R:H269	10.7157	7	1	5
45	R:R:Y286	7.214	5	2	9
46	R:R:D296	4.0425	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C9	R:R:V11	10.7237	3.42	No	No	0	8	3
2	R:R:E261	R:R:F172	10.0209	13.99	Yes	Yes	0	4	5
3	R:R:E170	R:R:Y98	22.239	6.73	Yes	Yes	0	4	5
4	R:R:F169	R:R:Y98	11.7006	16.5	Yes	Yes	0	4	5
5	R:R:F169	R:R:P152	11.4342	7.22	Yes	Yes	0	4	3
6	R:R:P152	R:R:W177	20.6364	6.76	Yes	Yes	0	3	1
7	R:R:E175	R:R:W177	15.7051	4.36	No	Yes	0	2	1
8	R:R:E175	R:R:K171	14.4385	8.1	No	No	0	2	3
9	R:R:K171	R:R:P173	11.8821	13.38	No	No	0	3	4
10	R:R:D16	R:R:H269	20.1537	13.87	Yes	Yes	1	5	5
11	R:R:F167	R:R:F172	12.5039	13.93	No	Yes	0	1	5
12	R:R:F167	R:R:H165	11.3261	4.53	No	Yes	0	1	1
13	R:R:D16	R:R:P20	18.3001	3.22	Yes	Yes	0	5	5
14	R:R:F19	R:R:P20	13.8284	4.33	No	Yes	0	5	5
15	R:R:F19	R:R:L23	10.8086	7.31	No	No	0	5	5
16	R:R:F97	R:R:Y98	13.4693	8.25	Yes	Yes	0	7	5
17	R:R:F97	R:R:Y66	10.2062	9.28	Yes	Yes	0	7	7
18	R:R:E170	R:R:Y76	18.5782	6.73	Yes	Yes	0	4	6
19	R:R:M181	R:R:P152	15.5816	6.71	No	Yes	0	4	3
20	R:R:M181	R:R:R185	37.0945	13.65	No	Yes	0	4	5
21	R:R:R185	R:R:Y102	32.2907	18.52	Yes	Yes	0	5	7
22	R:R:H241	R:R:Y102	45.9646	4.36	Yes	Yes	0	8	7
23	R:R:F237	R:R:H241	45.9762	5.66	Yes	Yes	8	8	8
24	R:R:F237	R:R:N278	100	10.87	Yes	No	0	8	9
25	R:R:D282	R:R:N278	65.234	13.46	No	No	0	9	9
26	R:R:D282	R:R:L59	15.2186	6.79	No	Yes	2	9	9
27	R:R:D63	R:R:L59	20.2618	4.07	Yes	Yes	2	9	9
28	R:R:D63	R:R:N35	17.8908	6.73	Yes	Yes	0	9	9
29	R:R:N35	R:R:P283	11.6736	13.03	Yes	No	0	9	9
30	R:R:D282	R:R:L108	49.5984	12.21	No	Yes	2	9	8
31	R:R:L108	R:R:Y286	60.519	11.72	Yes	Yes	2	8	9
32	R:R:I111	R:R:Y286	27.8383	6.04	No	Yes	0	9	9
33	R:R:I111	R:R:L52	26.8729	4.28	No	Yes	0	9	8
34	R:R:L52	R:R:N50	15.2417	4.12	Yes	No	0	8	7
35	R:R:N50	R:R:Q45	10.407	15.85	No	No	0	7	5
36	R:R:L229	R:R:Y286	27.4096	8.21	Yes	Yes	2	8	9
37	R:R:L225	R:R:L229	26.7416	2.77	No	Yes	0	8	8
38	R:R:L225	R:R:V289	25.6024	2.98	No	No	0	8	6
39	R:R:N290	R:R:V289	24.4748	4.43	No	No	0	8	6
40	R:R:A293	R:R:N290	23.3241	3.13	No	No	0	8	8
41	R:R:A293	R:R:C287	22.1656	3.61	No	No	0	8	8
42	R:R:A41	R:R:C287	20.9994	3.61	No	No	0	7	8
43	R:R:A41	R:R:D296	19.8255	4.63	No	Yes	0	7	4
44	R:R:M181	R:R:N149	31.3369	4.21	No	Yes	0	4	7
45	R:R:E145	R:R:N149	22.6213	5.26	No	Yes	0	7	7
46	R:R:E145	R:R:I103	21.7176	6.83	No	Yes	0	7	7
47	R:R:F107	R:R:I103	10.9669	7.54	Yes	Yes	4	8	7
48	R:R:N58	R:R:S138	17.4081	10.43	No	No	0	7	7
49	R:R:S138	R:R:V54	16.3384	4.85	No	Yes	0	7	5
50	R:R:I103	R:R:W142	10.0286	8.22	Yes	Yes	4	7	9
51	R:R:D114	R:R:Y55	13.4654	6.9	No	Yes	0	8	7
52	R:R:A134	R:R:Y55	11.4998	5.34	No	Yes	0	5	7
53	R:R:A134	R:R:V54	12.3687	5.09	No	Yes	0	5	5
54	R:R:I101	R:R:Y102	17.6784	9.67	No	Yes	0	8	7
55	R:R:W83	R:R:Y76	16.964	4.82	Yes	Yes	0	9	6
56	R:R:C168	R:R:W73	13.4577	6.53	No	Yes	0	9	7
57	R:R:C168	R:R:C90	13.728	5.46	No	No	0	9	9
58	R:R:C90	R:R:L158	10.3066	3.17	No	No	0	9	5
59	R:R:N278	R:R:V233	35.6619	4.43	No	No	0	9	9
60	R:R:M197	R:R:V233	16.8906	4.56	No	No	0	7	9
61	R:R:M197	R:R:S112	22.1694	4.6	No	No	0	7	9
62	R:R:S112	R:R:S200	21.0032	6.52	No	No	0	9	8
63	R:R:V233	R:R:W194	20.7909	7.36	No	No	0	9	6
64	R:R:I230	R:R:W194	15.5738	4.7	No	No	0	7	6
65	R:R:I230	R:R:Y201	14.4964	7.25	No	Yes	0	7	8
66	R:R:Y201	R:R:Y286	17.4004	4.96	Yes	Yes	2	8	9
67	R:R:F125	R:R:H121	13.8014	6.79	Yes	Yes	3	6	6
68	R:R:F125	R:R:L117	17.4583	2.44	Yes	No	0	6	6
69	R:R:L117	R:R:V113	18.6477	2.98	No	No	0	6	6
70	R:R:S200	R:R:V113	19.8293	3.23	No	No	0	8	6
71	R:R:E170	R:R:Y268	16.1762	5.61	Yes	Yes	1	4	5
72	R:R:R247	R:R:Y268	18.8716	21.61	No	Yes	0	4	5
73	R:R:M174	R:R:R247	13.6276	6.2	No	No	0	1	4
74	R:R:M174	R:R:Y251	12.3687	7.18	No	Yes	0	1	3
75	R:R:A226	R:R:Y201	28.1163	4	No	Yes	0	7	8
76	R:R:A226	R:R:L205	26.1392	4.73	No	No	0	7	5
77	R:R:I222	R:R:L205	20.1807	2.85	No	No	0	7	5
78	R:R:I222	R:R:V208	18.3387	13.83	No	No	0	7	8
79	R:R:K219	R:R:V208	16.3346	3.04	No	No	0	6	8
80	R:R:K219	R:R:T214	14.3227	10.51	No	No	0	6	3
81	R:R:Y240	R:R:Y268	56.9123	9.93	Yes	Yes	1	6	5
82	R:R:T275	R:R:Y240	58.7388	7.49	No	Yes	0	8	6
83	R:R:F237	R:R:T275	58.8238	7.78	Yes	No	0	8	8
84	R:R:F172	R:R:Y268	16.8984	4.13	Yes	Yes	1	5	5
85	R:R:H269	R:R:Y268	19.1728	6.53	Yes	Yes	1	5	5
86	R:R:R185	R:R:Y98	27.0196	12.35	Yes	Yes	0	5	5
87	R:R:D114	R:R:L52	14.2146	6.79	No	Yes	0	8	8
88	R:R:I101	R:R:Y66	17.3579	4.84	No	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ZCE_nogp

PDB Summary
PDB	8ZCE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4
Number of Linked Nodes	279
Number of Links	312
Number of Hubs	46
Number of Links mediated by Hubs	157
Number of Communities	8
Number of Nodes involved in Communities	40
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	55073
Length Of Smallest Path	3
Average Path Length	13.8358
Length of Longest Path	32
Minimum Path Strength	1.545
Average Path Strength	7.49917
Maximum Path Strength	22.805
Minimum Path Correlation	0.7
Average Path Correlation	0.929128
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	49.6518
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4036
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell adhesion • regulation of cell adhesion • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • positive regulation of cell communication • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • Rho protein signal transduction • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • regulation of vascular permeability • circulatory system process • vascular process in circulatory system • regulation of biological quality • blood circulation • cellular developmental process • connective tissue development • mesangial cell development • cell development • epithelial cell differentiation • renal system development • kidney vasculature development • pericyte cell differentiation • renal system vasculature development • mesangial cell differentiation • cell differentiation • nephron development • epithelial cell differentiation involved in kidney development • blood vessel development • epithelium development • tissue development • glomerular mesangium development • glomerular mesangial cell development • vasculature development • glomerular mesangial cell differentiation • circulatory system development • glomerulus development • epithelial cell development • cell differentiation involved in kidney development • glomerulus vasculature development • kidney development • regulation of developmental process • negative regulation of biological process • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • anatomical structure morphogenesis • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of multicellular organismal process • response to pH • response to abiotic stimulus • response to acidic pH • wound healing • angiogenesis involved in wound healing • response to wounding
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46093
Sequence	>8ZCE_nogp_Chain_R E G C H V D S R V D H L F P P S L Y I V I G V G L P T N C L A L W A A Y R Q V Q Q R N E L G Y L M L S I A D L Y I C T L P W V D Y F H H D N W I H G P G S C K L F F I F Y T N I Y I S I A F L C C I V D R Y L A V A H P L R F R L R R V T V A V S S V V W A T E L G A N S A P L F H D E L F R D R Y N H T C F E K F P M E G W V A W M N L Y R F V G F F P W A M L S Y R L R V R G S V S T E R Q E K A K I K L A L S L A I V L V C F A P Y H V L L S R S A I Y G R P W D C G F E E R V F S A Y H S S A F T S L N C V D P I Y L V N E G A R S D A K A L F V N L L L G S A K A F V L L L G I A R I L L L A L C V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JCP	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZCE	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCE (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFU	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	3.23	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8Z3M	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-04-23	To be published
	8Z3M (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	To be published
	8Z3Q	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-04-23	To be published
	8Z3Q (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.76	2025-04-23	To be published
	8Z65	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-04-23	To be published
	8Z65 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.98	2025-04-23	To be published
	8Z66	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.06	2025-04-23	To be published
	8Z67	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-04-23	To be published
	9LMO	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-07-09	To be published
	9LMP	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	2.65	2025-07-02	To be published
	8Z3Y	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2025-06-04	To be published
	8Z3Y (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.2	2025-06-04	To be published
	8Z9P	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gi1/β1/γ2	2.5	2025-07-09	To be published
	8Z9P (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.5	2025-07-09	To be published
	9IV6	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.71	2025-07-30	To be published
	9IV6 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.71	2025-07-30	To be published
	8Z9O	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.4	2025-07-16	To be published
	8Z9O (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.4	2025-07-16	To be published

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Download 8ZCE_nogp.zip

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