Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:D16 7.22525
2R:R:F19 2.73405
3R:R:P20 5.5975425
4R:R:Y24 6.02609
5R:R:V54 3.2775407
6R:R:Y55 7.736537
7R:R:D63 5.9575409
8R:R:Y66 6.36667607
9R:R:W73 7.338507
10R:R:F77 6.79286725
11R:R:W83 7.40167669
12R:R:H85 4.9825467
13R:R:F97 10.46407
14R:R:F107 8.5925448
15R:R:R115 5.335419
16R:R:Y116 7.2725408
17R:R:H121 4.55406
18R:R:W142 6.262549
19R:R:E145 4.125407
20R:R:F169 12.6325404
21R:R:K171 9.6453
22R:R:N182 7.7675405
23R:R:Y201 5.67508
24R:R:T214 4.135403
25R:R:L229 5.645408
26R:R:F237 6.75667618
27R:R:Y240 7.414506
28R:R:Y251 6.694503
29R:R:Y268 9.725425
30R:R:H269 8.02525
31R:R:D282 7.7575419
32R:R:Y286 6.275419
33R:R:C287 2.235407
34W:W:?2 6.4625400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M174 R:R:V178 10.55164.56NoNo012
2R:R:D161 R:R:Y163 18.268910.34NoNo023
3R:R:H10 R:R:Y163 12.20057.62NoNo033
4R:R:D161 R:R:H165 27.524111.35NoNo021
5R:R:D16 R:R:F77 13.24997.17YesYes255
6R:R:F77 R:R:Y76 24.881313.41YesNo056
7R:R:D81 R:R:Y76 27.085511.49NoNo046
8R:R:D81 R:R:H165 24.55657.56NoNo041
9R:R:D16 R:R:S13 12.82245.89YesNo055
10R:R:H17 R:R:S13 10.268412.55NoNo055
11R:R:F77 R:R:P20 12.72245.78YesYes255
12R:R:F19 R:R:P20 11.53154.33YesYes055
13R:R:A273 R:R:Y24 14.0665.34NoYes059
14R:R:F77 R:R:Y24 38.01186.19YesYes059
15R:R:A273 R:R:L23 12.07284.73NoNo055
16R:R:L70 R:R:Y24 17.372210.55NoYes089
17R:R:F97 R:R:Y24 19.88735.16YesYes079
18R:R:F97 R:R:W73 26.388716.04YesYes077
19R:R:F77 R:R:W73 19.88175.01YesYes057
20R:R:W73 R:R:W83 20.76177.5YesYes079
21R:R:W83 R:R:Y76 10.77645.79YesNo096
22R:R:S276 R:R:Y24 18.2555.09NoYes079
23R:R:L23 R:R:L277 10.07412.77NoNo055
24R:R:N182 R:R:V178 16.68384.43YesNo052
25R:R:R185 R:R:Y102 14.36316.46NoNo057
26R:R:I101 R:R:Y102 15.712216.92NoNo087
27R:R:I101 R:R:Y66 19.30164.84NoYes087
28R:R:C279 R:R:Y66 94.32034.03NoYes097
29R:R:C279 R:R:D63 93.79014.67NoYes099
30R:R:D63 R:R:N35 31.34669.42YesNo099
31R:R:N35 R:R:P283 24.084611.4NoNo099
32R:R:E170 R:R:Y98 12.65037.86NoNo045
33R:R:F169 R:R:Y98 38.317213.41YesNo045
34R:R:E157 R:R:F169 45.801320.99NoYes054
35R:R:E157 R:R:K91 45.018510.8NoNo056
36R:R:K91 R:R:L153 44.23014.23NoNo064
37R:R:F95 R:R:L153 41.02110.96NoNo064
38R:R:F95 R:R:L146 38.55598.53NoNo063
39R:R:L146 R:R:W142 37.72316.83NoYes039
40R:R:I103 R:R:W142 31.73818.22NoYes079
41R:R:E145 R:R:I103 30.86086.83YesNo077
42R:R:E145 W:W:?1 27.29655.24YesNo070
43R:R:C110 W:W:?1 24.61483.59NoNo070
44R:R:C110 R:R:Y55 23.69328.06NoYes077
45R:R:A134 R:R:Y55 18.03295.34NoYes387
46R:R:A134 R:R:V54 17.26125.09NoYes087
47R:R:V46 R:R:V54 12.33383.21NoYes067
48R:R:G94 R:R:W73 10.58214.22NoYes067
49R:R:L244 R:R:N182 15.659413.73NoYes055
50R:R:L244 R:R:Y240 16.486712.89NoYes056
51R:R:T275 R:R:Y240 24.11793.75NoYes086
52R:R:F237 R:R:T275 27.37977.78YesNo088
53R:R:F237 R:R:N278 26.166614.5YesNo189
54R:R:D282 R:R:N278 27.17999.42YesNo199
55R:R:D282 R:R:L108 1009.5YesNo198
56R:R:L108 R:R:Y286 99.51147.03NoYes189
57R:R:S200 W:W:?2 40.45194.24NoYes080
58R:R:S112 R:R:S200 42.52566.52NoNo098
59R:R:M197 R:R:S112 44.59376.13NoNo079
60R:R:M197 R:R:Y201 46.65633.59NoYes078
61R:R:R115 R:R:Y201 43.39455.14YesYes098
62R:R:R115 R:R:Y286 45.35996.17YesYes199
63R:R:L229 R:R:Y201 42.98647.03YesYes088
64R:R:L229 R:R:Y286 47.45585.86YesYes089
65R:R:Y116 W:W:?2 27.893314.57YesYes080
66R:R:H121 R:R:Y116 12.98897.62YesYes068
67R:R:H269 R:R:Y268 14.06055.44YesYes255
68R:R:Y240 R:R:Y268 23.02975.96YesYes065
69R:R:I230 R:R:Y201 12.96677.25NoYes078
70R:R:I230 R:R:W194 10.83753.52NoNo076
71R:R:A226 R:R:Y201 27.58795.34NoYes078
72R:R:A226 R:R:L205 25.53091.58NoNo075
73R:R:I222 R:R:L205 19.28212.85NoNo075
74R:R:I222 R:R:V208 17.26954.61NoNo078
75R:R:K219 R:R:V208 15.1323.04NoNo068
76R:R:K219 R:R:T214 12.98894.5NoYes063
77R:R:A293 R:R:N290 10.36564.69NoNo088
78R:R:A293 R:R:C287 11.65093.61NoYes087
79R:R:A38 R:R:C287 20.37861.81NoYes097
80R:R:A38 R:R:P283 21.61951.87NoNo099
81R:R:L70 R:R:Y66 18.26339.38NoYes087
82R:R:F97 R:R:Y66 67.612410.32YesYes077
83R:R:S276 R:R:Y66 19.74023.82NoYes077
84R:R:D282 R:R:D63 79.40765.32YesYes099
85R:R:F97 R:R:Y98 29.042610.32YesNo075
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C109 R:R:L196 4.76 0 No No 8 6 2 1
R:R:S112 R:R:S200 6.52 0 No No 9 8 2 1
R:R:A120 R:R:Y116 4 0 No Yes 7 8 2 1
R:R:H121 R:R:Y116 7.62 0 Yes Yes 6 8 2 1
R:R:Y116 W:W:?2 14.57 0 Yes Yes 8 0 1 0
R:R:F192 R:R:L196 13.4 0 No No 5 6 2 1
R:R:L196 W:W:?2 3.91 0 No Yes 6 0 1 0
R:R:S200 W:W:?2 4.24 0 No Yes 8 0 1 0
R:R:L199 W:W:?2 3.13 0 No Yes 5 0 1 0
R:R:G203 R:R:Y116 2.9 0 No Yes 4 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C110 R:R:Y55 8.06 0 No Yes 7 7 1 2
R:R:E145 R:R:I103 6.83 0 Yes No 7 7 1 2
R:R:V113 W:W:?1 8.42 0 No No 6 0 1 0
R:R:E145 W:W:?1 5.24 0 Yes No 7 0 1 0
R:R:C110 W:W:?1 3.59 0 No No 7 0 1 0
R:R:A106 R:R:E145 3.02 0 No Yes 6 7 2 1
R:R:L117 R:R:V113 2.98 0 No No 6 6 2 1
R:R:E145 R:R:T144 1.41 0 Yes No 7 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9JCQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.68
Number of Linked Nodes 287
Number of Links 312
Number of Hubs 34
Number of Links mediated by Hubs 132
Number of Communities 6
Number of Nodes involved in Communities 30
Number of Links involved in Communities 37
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 74785
Length Of Smallest Path 3
Average Path Length 15.6534
Length of Longest Path 37
Minimum Path Strength 1.315
Average Path Strength 7.18235
Maximum Path Strength 23.17
Minimum Path Correlation 0.7
Average Path Correlation 0.938137
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 48.8326
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.2892
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeA1L
PDB ResiduesW:W:?1 W:W:?2
Environment DetailsOpen EMBL-EBI Page
CodeA1L
Name[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
FormulaC24 H31 N9 O3
Molecular Weight493.561
SMILES
PubChem44129754
Formal Charge0
Total Atoms67
Total Chiral Atoms1
Total Bonds68
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JCQ_nogp_Chain_R
GCHVDSRVD HLFPPSLYI FVIGVGLPT NCLALWAAY RQVQQRNEL 
GVYLMNLSI ADLLYICTL PLWVDYFLH HDNWIHGPG SCKLFGFIF 
YTNIYISIA FLCCISVDR YLAVAHPLR FARLRRVKT AVAVSSVVW 
ATELGANSA PLFHDELFR DRYNHTFCF EKFPMEGWV AWMNLYRVF 
VGFLFPWAL MLLSYRGIL RAVRGSVST ERQEKAKIK RLALSLIAI 
VLVCFAPYH VLLLSRSAI YLGRPWDCG FEERVFSAY HSSLAFTSL 
NCVADPILY CLVNEGARS DVAKALHNL LRF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JCQ_nogp.zip



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