psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D14	R:R:E264	7.8	No	No	0	6	3
2	R:R:H167	R:R:S15	6.97	Yes	No	0	3	4
3	R:R:E264	R:R:R16	6.98	No	Yes	0	3	4
4	R:R:R16	R:R:R265	5.33	Yes	No	0	4	1
5	R:R:F267	R:R:R16	6.41	No	Yes	0	4	4
6	R:R:R16	R:R:S268	5.27	Yes	No	0	4	2
7	R:R:H19	R:R:V17	9.69	No	No	0	5	4
8	R:R:D18	R:R:P22	16.1	No	Yes	1	6	5
9	R:R:D18	R:R:F79	8.36	No	Yes	1	6	4
10	R:R:D18	R:R:H271	11.35	No	Yes	1	6	4
11	R:R:H19	R:R:H82	11.94	No	No	0	5	4
12	R:R:F21	R:R:P22	4.33	No	Yes	0	6	5
13	R:R:F21	R:R:L25	3.65	No	No	0	6	6
14	R:R:F21	R:R:S272	3.96	No	No	0	6	5
15	R:R:P22	R:R:P23	9.74	Yes	No	0	5	6
16	R:R:F79	R:R:P22	7.22	Yes	Yes	1	4	5
17	R:R:L25	R:R:L279	4.15	No	No	0	6	5
18	R:R:L72	R:R:Y26	9.38	No	Yes	0	8	8
19	R:R:F99	R:R:Y26	4.13	Yes	Yes	0	6	8
20	R:R:A275	R:R:Y26	4	No	Yes	0	4	8
21	R:R:S278	R:R:Y26	5.09	No	Yes	0	6	8
22	R:R:F28	R:R:V32	7.87	No	No	0	4	5
23	R:R:S278	R:R:V29	8.08	No	No	0	6	7
24	R:R:G31	R:R:I30	3.53	No	No	0	5	7
25	R:R:I30	R:R:I69	4.42	No	No	0	7	5
26	R:R:I30	R:R:L72	7.14	No	No	0	7	8
27	R:R:V282	R:R:V32	4.81	No	No	0	6	5
28	R:R:L34	R:R:P35	3.28	No	No	0	6	4
29	R:R:I69	R:R:L34	14.27	No	No	0	5	6
30	R:R:P285	R:R:T36	6.99	No	No	0	9	7
31	R:R:D65	R:R:N37	13.46	Yes	No	0	9	9
32	R:R:N37	R:R:P285	13.03	No	No	0	9	9
33	R:R:L39	R:R:V299	4.47	No	Yes	5	6	5
34	R:R:L303	R:R:L39	4.15	No	No	5	7	6
35	R:R:A40	R:R:C289	3.61	No	No	0	8	6
36	R:R:L41	R:R:S62	7.51	No	No	0	7	8
37	R:R:R46	R:R:W42	6	No	No	0	5	3
38	R:R:D298	R:R:W42	5.58	No	No	0	5	3
39	R:R:A302	R:R:W42	7.78	No	No	0	5	3
40	R:R:A43	R:R:D298	4.63	No	No	0	6	5
41	R:R:R49	R:R:Y45	5.14	No	No	0	6	1
42	R:R:M59	R:R:Y45	3.59	No	No	0	5	1
43	R:R:K301	R:R:R46	9.9	No	No	0	5	5
44	R:R:N52	R:R:Q47	13.2	No	No	0	7	5
45	R:R:G55	R:R:Q47	3.29	No	No	0	7	5
46	R:R:M59	R:R:V48	4.56	No	No	0	5	5
47	R:R:E53	R:R:N52	6.57	No	No	0	6	7
48	R:R:L54	R:R:N52	4.12	No	No	0	7	7
49	R:R:D116	R:R:E53	12.99	Yes	No	6	8	6
50	R:R:E53	R:R:R131	11.63	No	No	6	6	7
51	R:R:D116	R:R:L54	5.43	Yes	No	0	8	7
52	R:R:G55	R:R:L58	5.13	No	No	0	7	7
53	R:R:A136	R:R:V56	5.09	No	Yes	0	7	6
54	R:R:S140	R:R:V56	3.23	No	Yes	3	6	6
55	R:R:C112	R:R:Y57	4.03	No	Yes	0	6	7
56	R:R:D116	R:R:Y57	9.2	Yes	Yes	0	8	7
57	R:R:A136	R:R:Y57	5.34	No	Yes	0	7	7
58	R:R:V139	R:R:Y57	3.79	No	Yes	0	4	7
59	R:R:L58	R:R:Y288	3.52	No	Yes	0	7	9
60	R:R:F109	R:R:N60	12.08	Yes	No	3	7	9
61	R:R:N60	R:R:S140	11.92	No	No	3	9	6
62	R:R:N60	R:R:W144	6.78	No	Yes	3	9	9
63	R:R:D65	R:R:L61	4.07	Yes	Yes	2	9	9
64	R:R:L110	R:R:L61	5.54	Yes	Yes	2	8	9
65	R:R:D284	R:R:L61	8.14	Yes	Yes	2	9	9
66	R:R:I63	R:R:W144	3.52	No	Yes	0	5	9
67	R:R:A64	R:R:I105	3.25	No	Yes	0	8	6
68	R:R:C281	R:R:D65	7.78	No	Yes	0	8	9
69	R:R:D284	R:R:D65	3.99	Yes	Yes	2	9	9
70	R:R:L67	R:R:N102	4.12	No	No	0	6	8
71	R:R:L72	R:R:Y68	5.86	No	Yes	0	8	5
72	R:R:F99	R:R:Y68	8.25	Yes	Yes	0	6	5
73	R:R:N102	R:R:Y68	11.63	No	Yes	0	8	5
74	R:R:S278	R:R:Y68	8.9	No	Yes	0	6	5
75	R:R:C281	R:R:Y68	5.38	No	Yes	0	8	5
76	R:R:I98	R:R:T71	12.16	No	No	0	5	6
77	R:R:L74	R:R:P73	3.28	No	No	0	6	9
78	R:R:F95	R:R:L74	14.61	No	No	0	5	6
79	R:R:W75	R:R:Y78	8.68	Yes	Yes	1	6	5
80	R:R:G96	R:R:W75	5.63	No	Yes	0	6	6
81	R:R:F99	R:R:W75	39.09	Yes	Yes	1	6	6
82	R:R:W75	R:R:Y100	4.82	Yes	Yes	1	6	5
83	R:R:E172	R:R:W75	3.27	Yes	Yes	1	5	6
84	R:R:D77	R:R:H81	7.56	No	No	0	4	4
85	R:R:D77	R:R:W85	7.82	No	Yes	0	4	9
86	R:R:F79	R:R:Y78	10.32	Yes	Yes	1	4	5
87	R:R:D83	R:R:Y78	6.9	No	Yes	0	4	5
88	R:R:W85	R:R:Y78	15.43	Yes	Yes	1	9	5
89	R:R:E172	R:R:Y78	13.47	Yes	Yes	1	5	5
90	R:R:F79	R:R:H271	10.18	Yes	Yes	1	4	4
91	R:R:N84	R:R:T168	5.85	No	No	0	4	4
92	R:R:I86	R:R:W85	4.7	No	Yes	0	3	9
93	R:R:H87	R:R:W85	29.62	Yes	Yes	1	7	9
94	R:R:C170	R:R:W85	6.53	No	Yes	1	9	9
95	R:R:H87	R:R:S91	5.58	Yes	No	0	7	4
96	R:R:C92	R:R:H87	5.9	No	Yes	1	9	7
97	R:R:C170	R:R:H87	4.42	No	Yes	1	9	7
98	R:R:G88	R:R:P89	4.06	No	No	0	7	4
99	R:R:F95	R:R:S91	7.93	No	No	0	5	4
100	R:R:C170	R:R:C92	7.28	No	No	1	9	9
101	R:R:K93	R:R:L155	5.64	No	No	0	7	4
102	R:R:F95	R:R:L94	7.31	No	No	0	5	5
103	R:R:F97	R:R:N151	10.87	No	No	0	5	6
104	R:R:F97	R:R:L155	15.83	No	No	0	5	4
105	R:R:I98	R:R:N102	5.66	No	No	0	5	8
106	R:R:F99	R:R:Y100	9.28	Yes	Yes	1	6	5
107	R:R:F99	R:R:L274	4.87	Yes	No	1	6	5
108	R:R:F171	R:R:Y100	6.19	No	Yes	0	4	5
109	R:R:E172	R:R:Y100	3.37	Yes	Yes	1	5	5
110	R:R:L274	R:R:Y100	3.52	No	Yes	1	5	5
111	R:R:N151	R:R:S101	8.94	No	No	0	6	5
112	R:R:I103	R:R:Y104	15.71	No	Yes	0	7	7
113	R:R:I103	R:R:T277	4.56	No	No	0	7	8
114	R:R:R187	R:R:Y104	10.29	No	Yes	0	5	7
115	R:R:H243	R:R:Y104	4.36	Yes	Yes	0	8	7
116	R:R:I105	R:R:W144	10.57	Yes	Yes	0	6	9
117	R:R:I107	R:R:P195	6.77	No	No	0	7	9
118	R:R:A108	R:R:E147	4.53	No	No	0	5	7
119	R:R:F109	R:R:S140	3.96	Yes	No	3	7	6
120	R:R:F109	R:R:V143	9.18	Yes	No	0	7	6
121	R:R:F109	R:R:W144	12.03	Yes	Yes	3	7	9
122	R:R:L110	R:R:M199	4.24	Yes	No	0	8	7
123	R:R:D284	R:R:L110	12.21	Yes	Yes	2	9	8
124	R:R:L110	R:R:Y288	7.03	Yes	Yes	2	8	9
125	R:R:C111	R:R:L198	4.76	No	No	0	7	5
126	R:R:I113	R:R:R117	3.76	No	No	2	8	9
127	R:R:I113	R:R:Y288	4.84	No	Yes	2	8	9
128	R:R:C202	R:R:S114	5.16	No	No	0	6	9
129	R:R:S114	R:R:Y203	13.99	No	Yes	0	9	8
130	R:R:C202	R:R:V115	3.42	No	No	0	6	5
131	R:R:D116	R:R:R131	3.57	Yes	No	6	8	7
132	R:R:R117	R:R:Y203	8.23	No	Yes	0	9	8
133	R:R:R117	R:R:Y288	6.17	No	Yes	2	9	9
134	R:R:A122	R:R:Y118	5.34	No	Yes	7	6	8
135	R:R:H123	R:R:Y118	11.98	Yes	Yes	7	6	8
136	R:R:I206	R:R:Y118	3.63	No	Yes	0	8	8
137	R:R:F127	R:R:L119	7.31	No	No	0	5	5
138	R:R:A120	R:R:R131	4.15	No	No	0	7	7
139	R:R:A122	R:R:H123	7.32	No	Yes	7	6	6
140	R:R:F127	R:R:H123	7.92	No	Yes	0	5	6
141	R:R:L125	R:R:P124	4.93	No	No	0	5	8
142	R:R:R132	R:R:T135	3.88	No	No	0	6	4
143	R:R:G149	R:R:S152	3.71	No	No	0	3	4
144	R:R:F171	R:R:P154	7.22	No	No	0	4	6
145	R:R:P154	R:R:W179	6.76	No	Yes	0	6	3
146	R:R:M183	R:R:P154	3.35	Yes	No	0	5	6
147	R:R:H157	R:R:W179	19.04	No	Yes	0	4	3
148	R:R:E159	R:R:F171	9.33	No	No	0	4	4
149	R:R:F161	R:R:F169	10.72	No	No	0	3	2
150	R:R:F161	R:R:K173	22.33	No	No	0	3	4
151	R:R:R162	R:R:T168	11.64	No	No	0	2	4
152	R:R:D163	R:R:H167	17.65	No	Yes	4	1	3
153	R:R:D163	R:R:F169	11.94	No	No	4	1	2
154	R:R:H167	R:R:Y165	5.44	Yes	No	0	3	2
155	R:R:F169	R:R:H167	19.23	No	Yes	4	2	3
156	R:R:E172	R:R:H271	9.85	Yes	Yes	1	5	4
157	R:R:E177	R:R:K173	8.1	No	No	0	4	4
158	R:R:F174	R:R:P175	4.33	No	No	0	4	4
159	R:R:E263	R:R:F174	9.33	No	No	0	3	4
160	R:R:M176	R:R:V180	6.09	Yes	No	0	3	5
161	R:R:M176	R:R:R249	14.89	Yes	No	8	3	5
162	R:R:E263	R:R:M176	4.06	No	Yes	8	3	3
163	R:R:E177	R:R:W179	4.36	No	Yes	0	4	3
164	R:R:V180	R:R:W179	11.03	No	Yes	0	5	3
165	R:R:A181	R:R:S250	3.42	No	No	0	2	5
166	R:R:L254	R:R:W182	4.56	No	No	0	1	2
167	R:R:M183	R:R:Y186	3.59	Yes	No	0	5	4
168	R:R:M183	R:R:R187	7.44	Yes	No	0	5	5
169	R:R:N184	R:R:R187	7.23	No	No	0	5	5
170	R:R:L246	R:R:N184	15.1	No	No	0	6	5
171	R:R:V190	R:R:Y186	7.57	No	No	0	4	4
172	R:R:F189	R:R:V188	3.93	No	No	0	4	4
173	R:R:H243	R:R:V188	8.3	Yes	No	0	8	4
174	R:R:F192	R:R:L193	6.09	Yes	No	0	8	5
175	R:R:F192	R:R:V235	3.93	Yes	No	0	8	9
176	R:R:F192	R:R:F239	7.5	Yes	No	0	8	9
177	R:R:F192	R:R:H243	11.31	Yes	Yes	0	8	8
178	R:R:F194	R:R:P195	4.33	No	No	0	5	9
179	R:R:F194	R:R:L198	7.31	No	No	0	5	5
180	R:R:L200	R:R:W196	4.56	No	No	0	3	5
181	R:R:V235	R:R:W196	6.13	No	No	0	9	5
182	R:R:L236	R:R:W196	7.97	No	No	0	5	5
183	R:R:I232	R:R:L200	4.28	No	No	0	7	3
184	R:R:L201	R:R:R204	3.64	No	No	0	4	3
185	R:R:L231	R:R:Y203	7.03	No	Yes	0	7	8
186	R:R:R204	R:R:R208	6.4	No	No	0	3	4
187	R:R:K225	R:R:L207	4.23	No	No	0	5	4
188	R:R:A228	R:R:L207	4.73	No	No	0	7	4
189	R:R:K221	R:R:V210	4.55	No	No	0	6	8
190	R:R:S213	R:R:T216	9.59	No	No	0	6	3
191	R:R:E220	R:R:T216	4.23	No	No	0	5	3
192	R:R:K221	R:R:T216	4.5	No	No	0	6	3
193	R:R:R226	R:R:V222	3.92	No	No	0	6	5
194	R:R:K225	R:R:L229	4.23	No	No	0	5	4
195	R:R:L231	R:R:L287	6.92	No	No	0	7	8
196	R:R:L231	R:R:Y288	8.21	No	Yes	0	7	9
197	R:R:I234	R:R:L287	4.28	No	No	0	6	8
198	R:R:F239	R:R:T277	5.19	No	No	0	9	8
199	R:R:F239	R:R:N280	9.67	No	No	0	9	9
200	R:R:H243	R:R:Y242	8.71	Yes	Yes	0	8	7
201	R:R:S273	R:R:Y242	3.82	No	Yes	0	7	7
202	R:R:L274	R:R:Y242	10.55	No	Yes	0	5	7
203	R:R:T277	R:R:Y242	4.99	No	Yes	0	8	7
204	R:R:L245	R:R:S273	6.01	No	No	0	4	7
205	R:R:L246	R:R:Y270	3.52	No	No	0	6	4
206	R:R:E263	R:R:R249	11.63	No	No	8	3	5
207	R:R:R249	R:R:Y270	19.55	No	No	0	5	4
208	R:R:F262	R:R:V252	23.6	No	No	0	1	2
209	R:R:L254	R:R:Y253	3.52	No	No	0	1	3
210	R:R:P257	R:R:Y253	9.74	No	No	0	1	3
211	R:R:F267	R:R:H271	13.58	No	Yes	0	4	4
212	R:R:H271	R:R:Y270	3.27	Yes	No	0	4	4
213	R:R:D284	R:R:N280	12.12	Yes	No	0	9	9
214	R:R:D284	R:R:Y288	4.6	Yes	Yes	2	9	9
215	R:R:G294	R:R:N292	3.39	No	No	0	7	8
216	R:R:A295	R:R:N292	4.69	No	No	0	8	8
217	R:R:G294	R:R:S297	3.71	No	No	0	7	5
218	R:R:D298	R:R:V299	4.38	No	Yes	0	5	5
219	R:R:L303	R:R:V299	4.47	No	Yes	5	7	5
220	R:R:K301	R:R:N305	12.59	No	No	0	5	4
221	R:R:A44	R:R:M59	3.22	No	No	0	6	5
222	R:R:A153	R:R:M183	3.22	No	Yes	0	8	5
223	R:R:V48	R:R:V56	3.21	No	Yes	3	5	6
224	R:R:C238	R:R:N280	3.15	No	No	0	7	9
225	R:R:I27	R:R:S24	3.1	No	No	0	4	4
226	R:R:I105	R:R:S101	3.1	Yes	No	0	6	5
227	R:R:I107	R:R:V235	3.07	No	No	0	7	9
228	R:R:I224	R:R:V210	3.07	No	No	0	6	8
229	R:R:L61	R:R:S106	3	Yes	No	2	9	9
230	R:R:L110	R:R:S106	3	Yes	No	2	8	9
231	R:R:R178	R:R:W182	3	No	No	0	3	2
232	R:R:L185	R:R:S250	3	No	No	0	4	5
233	R:R:L287	R:R:S230	3	No	No	0	8	5
234	R:R:L227	R:R:V291	2.98	No	No	0	7	6
235	R:R:L245	R:R:V266	2.98	No	No	0	4	5
236	R:R:G191	R:R:Y104	2.9	No	Yes	0	6	7
237	R:R:G205	R:R:Y118	2.9	No	Yes	0	4	8
238	R:R:F276	R:R:P241	2.89	No	No	0	7	9
239	R:R:I63	R:R:L41	2.85	No	No	0	5	7
240	R:R:I105	R:R:L148	2.85	Yes	No	0	6	4
241	R:R:C260	R:R:F174	2.79	No	No	0	7	4
242	R:R:L41	R:R:L66	2.77	No	No	0	7	7
243	R:R:E147	R:R:I105	2.73	No	Yes	0	7	6
244	R:R:N166	R:R:N84	2.72	No	No	0	5	4
245	R:R:D77	R:R:L80	2.71	No	No	0	4	4
246	R:R:C202	R:R:Y118	2.69	No	Yes	0	6	8
247	R:R:A150	R:R:Y186	2.67	No	No	0	5	4
248	R:R:A228	R:R:Y203	2.67	No	Yes	0	7	8
249	R:R:E293	R:R:N292	2.63	No	No	0	5	8
250	R:R:F276	R:R:L279	2.44	No	No	0	7	5
251	R:R:M176	R:R:Y253	2.39	Yes	No	0	3	3
252	R:R:Q50	R:R:R46	2.34	No	No	0	6	5
253	R:R:D259	R:R:W258	2.23	No	No	0	4	1
254	R:R:G33	R:R:P35	2.03	No	No	0	8	4
255	R:R:G90	R:R:P89	2.03	No	No	0	1	4
256	R:R:R256	R:R:W258	2	No	No	0	2	1
257	R:R:A40	R:R:P285	1.87	No	No	0	8	9
258	R:R:A240	R:R:P241	1.87	No	No	0	5	9
259	R:R:G33	R:R:V282	1.84	No	No	0	8	6
260	R:R:A43	R:R:C289	1.81	No	No	0	6	6
261	R:R:A295	R:R:C289	1.81	No	No	0	8	6
262	R:R:A122	R:R:A209	1.79	No	No	0	6	5
263	R:R:P23	R:R:V76	1.77	No	No	0	6	7
264	R:R:P73	R:R:V76	1.77	No	No	0	9	7
265	R:R:G149	R:R:L148	1.71	No	No	0	3	4
266	R:R:A209	R:R:V121	1.7	No	No	0	5	8
267	R:R:A269	R:R:V266	1.7	No	No	0	4	5
268	R:R:C70	R:R:T71	1.69	No	No	0	4	6
269	R:R:D259	R:R:G261	1.68	No	No	0	4	3
270	R:R:S213	R:R:S215	1.63	No	No	0	6	4
271	R:R:S141	R:R:V142	1.62	No	No	0	3	3
272	R:R:A283	R:R:I234	1.62	No	No	0	6	6
273	R:R:V133	R:R:V48	1.6	No	No	3	4	5
274	R:R:V133	R:R:V56	1.6	No	Yes	3	4	6
275	R:R:V137	R:R:V56	1.6	No	Yes	0	4	6
276	R:R:C38	R:R:L66	1.59	No	No	0	2	7
277	R:R:T135	R:R:V139	1.59	No	No	0	4	4
278	R:R:A181	R:R:L254	1.58	No	No	0	2	1
279	R:R:I27	R:R:V76	1.54	No	No	0	4	7
280	R:R:I286	R:R:V291	1.54	No	No	0	6	6
281	R:R:H123	R:R:P124	1.53	Yes	No	0	6	8
282	R:R:I286	R:R:T36	1.52	No	No	0	6	7
283	R:R:F262	R:R:G261	1.51	No	No	0	1	3
284	R:R:G205	R:R:R208	1.5	No	No	0	4	4
285	R:R:L245	R:R:S248	1.5	No	No	0	4	5
286	R:R:L290	R:R:V299	1.49	No	Yes	0	7	5
287	R:R:P257	R:R:R256	1.44	No	No	0	1	2
288	R:R:I224	R:R:L207	1.43	No	No	0	6	4
289	R:R:E147	R:R:T146	1.41	No	No	0	7	4
290	R:R:H51	R:R:V133	1.38	No	No	0	6	4
291	R:R:L119	R:R:L130	1.38	No	No	0	5	5
292	R:R:L185	R:R:L247	1.38	No	No	0	4	5
293	R:R:F276	R:R:V237	1.31	No	No	0	7	6
294	R:R:R129	R:R:T135	1.29	No	No	0	4	4
295	R:R:H304	R:R:L303	1.29	No	No	0	4	7
296	R:R:H81	R:R:N84	1.28	No	No	0	4	4
297	R:R:K134	R:R:R132	1.24	No	No	0	4	6
298	R:R:F156	R:R:L155	1.22	No	No	0	4	4
299	R:R:L125	R:R:R126	1.21	No	No	0	5	4
300	R:R:Q211	R:R:R208	1.17	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R16	5.9975	4	0	4
2	R:R:P22	9.3475	4	1	5
3	R:R:Y26	5.65	4	0	8
4	R:R:V56	2.946	5	3	6
5	R:R:Y57	5.59	4	0	7
6	R:R:L61	5.1875	4	2	9
7	R:R:D65	7.325	4	2	9
8	R:R:Y68	8.004	5	0	5
9	R:R:W75	12.298	5	1	6
10	R:R:Y78	10.96	5	1	5
11	R:R:F79	9.02	4	1	4
12	R:R:W85	12.82	5	1	9
13	R:R:H87	11.38	4	1	7
14	R:R:F99	13.124	5	1	6
15	R:R:Y100	5.436	5	1	5
16	R:R:Y104	8.315	4	0	7
17	R:R:I105	4.5	5	0	6
18	R:R:F109	9.3125	4	3	7
19	R:R:L110	6.404	5	2	8
20	R:R:D116	7.7975	4	6	8
21	R:R:Y118	5.308	5	7	8
22	R:R:H123	7.1875	4	7	6
23	R:R:W144	8.225	4	3	9
24	R:R:H167	12.3225	4	4	3
25	R:R:E172	7.49	4	1	5
26	R:R:M176	6.8575	4	8	3
27	R:R:W179	10.2975	4	0	3
28	R:R:M183	4.4	4	0	5
29	R:R:F192	7.2075	4	0	8
30	R:R:Y203	7.98	4	0	8
31	R:R:Y242	7.0175	4	0	7
32	R:R:H243	8.17	4	0	8
33	R:R:H271	9.646	5	1	4
34	R:R:D284	8.212	5	2	9
35	R:R:Y288	5.72833	6	2	9
36	R:R:V299	3.7025	4	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E172	R:R:H271	40.2903	9.85	Yes	Yes	1	5	4
2	R:R:E172	R:R:Y100	25.6001	3.37	Yes	Yes	1	5	5
3	R:R:F171	R:R:Y100	23.02	6.19	No	Yes	0	4	5
4	R:R:F171	R:R:P154	21.5007	7.22	No	No	0	4	6
5	R:R:P154	R:R:W179	20.5604	6.76	No	Yes	0	6	3
6	R:R:H271	R:R:Y270	31.8401	3.27	Yes	No	0	4	4
7	R:R:R249	R:R:Y270	30.3165	19.55	No	No	0	5	4
8	R:R:M176	R:R:R249	23.449	14.89	Yes	No	8	3	5
9	R:R:M176	R:R:V180	12.2961	6.09	Yes	No	0	3	5
10	R:R:V180	R:R:W179	12.8624	11.03	No	Yes	0	5	3
11	R:R:F79	R:R:P22	15.134	7.22	Yes	Yes	1	4	5
12	R:R:F21	R:R:P22	10.4619	4.33	No	Yes	0	6	5
13	R:R:E172	R:R:W75	18.0183	3.27	Yes	Yes	1	5	6
14	R:R:F99	R:R:W75	41.423	39.09	Yes	Yes	1	6	6
15	R:R:F99	R:R:Y100	36.4361	9.28	Yes	Yes	1	6	5
16	R:R:F99	R:R:Y68	74.8373	8.25	Yes	Yes	0	6	5
17	R:R:I30	R:R:L72	11.3515	7.14	No	No	0	7	8
18	R:R:C281	R:R:Y68	79.5495	5.38	No	Yes	0	8	5
19	R:R:C281	R:R:D65	79.7037	7.78	No	Yes	0	8	9
20	R:R:D65	R:R:N37	22.7369	13.46	Yes	No	0	9	9
21	R:R:N37	R:R:P285	21.9107	13.03	No	No	0	9	9
22	R:R:A40	R:R:P285	17.769	1.87	No	No	0	8	9
23	R:R:A40	R:R:C289	16.9174	3.61	No	No	0	8	6
24	R:R:A43	R:R:C289	11.7192	1.81	No	No	0	6	6
25	R:R:A43	R:R:D298	10.8381	4.63	No	No	0	6	5
26	R:R:D284	R:R:D65	82.4	3.99	Yes	Yes	2	9	9
27	R:R:D284	R:R:Y288	100	4.6	Yes	Yes	2	9	9
28	R:R:L58	R:R:Y288	85.893	3.52	No	Yes	0	7	9
29	R:R:G55	R:R:L58	85.5169	5.13	No	No	0	7	7
30	R:R:G55	R:R:Q47	85.1365	3.29	No	No	0	7	5
31	R:R:N52	R:R:Q47	84.7519	13.2	No	No	0	7	5
32	R:R:E53	R:R:N52	42.8218	6.57	No	No	0	6	7
33	R:R:D116	R:R:E53	41.0067	12.99	Yes	No	6	8	6
34	R:R:D116	R:R:Y57	81.1512	9.2	Yes	Yes	0	8	7
35	R:R:A136	R:R:Y57	72.7982	5.34	No	Yes	0	7	7
36	R:R:A136	R:R:V56	71.562	5.09	No	Yes	0	7	6
37	R:R:S140	R:R:V56	60.2464	3.23	No	Yes	3	6	6
38	R:R:N60	R:R:S140	28.7972	11.92	No	No	3	9	6
39	R:R:N60	R:R:W144	27.4681	6.78	No	Yes	3	9	9
40	R:R:I63	R:R:W144	13.902	3.52	No	Yes	0	5	9
41	R:R:I63	R:R:L41	11.1297	2.85	No	No	0	5	7
42	R:R:L54	R:R:N52	41.5434	4.12	No	No	0	7	7
43	R:R:D116	R:R:L54	41.0109	5.43	Yes	No	0	8	7
44	R:R:F109	R:R:S140	30.1686	3.96	Yes	No	3	7	6
45	R:R:F109	R:R:W144	27.5104	12.03	Yes	Yes	3	7	9
46	R:R:I105	R:R:W144	38.6633	10.57	Yes	Yes	0	6	9
47	R:R:F79	R:R:Y78	14.8762	10.32	Yes	Yes	1	4	5
48	R:R:W85	R:R:Y78	17.302	15.43	Yes	Yes	1	9	5
49	R:R:I105	R:R:S101	16.6702	3.1	Yes	No	0	6	5
50	R:R:N151	R:R:S101	13.902	8.94	No	No	0	6	5
51	R:R:F97	R:R:N151	11.1297	10.87	No	No	0	5	6
52	R:R:L274	R:R:Y242	12.2073	10.55	No	Yes	0	5	7
53	R:R:R187	R:R:Y104	10.8169	10.29	No	Yes	0	5	7
54	R:R:F192	R:R:H243	12.9004	11.31	Yes	Yes	0	8	8
55	R:R:F192	R:R:V235	10.4788	3.93	Yes	No	0	8	9
56	R:R:R117	R:R:Y288	25.6804	6.17	No	Yes	2	9	9
57	R:R:C202	R:R:S114	30.5109	5.16	No	No	0	6	9
58	R:R:S114	R:R:Y203	32.0746	13.99	No	Yes	0	9	8
59	R:R:R117	R:R:Y203	25.0655	8.23	No	Yes	0	9	8
60	R:R:L231	R:R:Y203	25.2641	7.03	No	Yes	0	7	8
61	R:R:L231	R:R:Y288	28.7993	8.21	No	Yes	0	7	9
62	R:R:C202	R:R:Y118	27.3709	2.69	No	Yes	0	6	8
63	R:R:H123	R:R:Y118	11.3727	11.98	Yes	Yes	7	6	8
64	R:R:L254	R:R:Y253	14.8783	3.52	No	No	0	1	3
65	R:R:M176	R:R:Y253	31.6309	2.39	Yes	No	0	3	3
66	R:R:F239	R:R:T277	10.8676	5.19	No	No	0	9	8
67	R:R:A228	R:R:Y203	17.7542	2.67	No	Yes	0	7	8
68	R:R:A228	R:R:L207	16.1483	4.73	No	No	0	7	4
69	R:R:I224	R:R:L207	11.3156	1.43	No	No	0	6	4
70	R:R:F239	R:R:N280	23.2208	9.67	No	No	0	9	9
71	R:R:P257	R:R:Y253	14.8783	9.74	No	No	0	1	3
72	R:R:P257	R:R:R256	12.7652	1.44	No	No	0	1	2
73	R:R:R256	R:R:W258	10.6479	2	No	No	0	2	1
74	R:R:W75	R:R:Y78	25.8875	8.68	Yes	Yes	1	6	5
75	R:R:F192	R:R:F239	12.6976	7.5	Yes	No	0	8	9
76	R:R:D284	R:R:N280	23.0264	12.12	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9JVH

PDB Summary
PDB	9JVH
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR4
Species	Mus Musculus
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.76
Date	2025-02-26
D.O.I.	10.1016/j.cell.2024.12.001

Net Summary
I_min	3.23
Number of Linked Nodes	272
Number of Links	300
Number of Hubs	36
Number of Links mediated by Hubs	129
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	87323
Length Of Smallest Path	3
Average Path Length	17.8071
Length of Longest Path	38
Minimum Path Strength	1.335
Average Path Strength	7.27958
Maximum Path Strength	23.885
Minimum Path Correlation	0.7
Average Path Correlation	0.931351
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	43.5447
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.9406
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell adhesion • regulation of cell adhesion • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cell communication • small GTPase-mediated signal transduction • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • Rho protein signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • regulation of vascular permeability • multicellular organismal process • system process • circulatory system process • vascular process in circulatory system • regulation of biological quality • blood circulation • cellular developmental process • connective tissue development • mesangial cell development • cell development • epithelial cell differentiation • renal system development • kidney vasculature development • multicellular organism development • pericyte cell differentiation • renal system vasculature development • mesangial cell differentiation • cell differentiation • anatomical structure development • nephron development • system development • epithelial cell differentiation involved in kidney development • blood vessel development • developmental process • epithelium development • animal organ development • tissue development • glomerular mesangium development • glomerular mesangial cell development • vasculature development • glomerular mesangial cell differentiation • circulatory system development • glomerulus development • epithelial cell development • cell differentiation involved in kidney development • glomerulus vasculature development • kidney development • regulation of developmental process • negative regulation of biological process • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • anatomical structure morphogenesis • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of multicellular organismal process • response to pH • response to abiotic stimulus • response to acidic pH • wound healing • angiogenesis involved in wound healing • response to wounding • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8BUD0
Sequence	>9JVH_Chain_R V D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V R Q H N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H D N W I H G P G S C K L F G F I F Y S N I Y I S I A F L C C I S V D R Y L A V A H P L R F A R L R R V K T A V A V S S V V W A T E L G A N S A P L F H D E L F R D R Y N H T F C F E K F P M E R W V A W M N L Y R V F V G F L F P W A L M L L C Y R G I L R A V Q S S V S T E R Q E K V K I K R L A L S L I A I V L V C F A P Y H A L L L S R S A V Y L G R P W D C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G A R S D V A K A L H N L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	10.1016/j.cell.2024.12.001
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZFJ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2024-08-07	To be published
	8ZFJ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.1	2024-08-07	To be published
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	10.1016/j.cell.2024.12.001

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JVH.zip

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