Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 3.925419
2A:A:Y37 6.8975414
3A:A:H41 5.322516
4A:A:R42 5.88419
5A:A:L43 3.36417
6A:A:L45 4.5525418
7A:A:L46 3.7925418
8A:A:N50 7.795419
9A:A:S51 3.038519
10A:A:G52 1.82419
11A:A:K53 3.7225419
12A:A:I56 4.5625417
13A:A:I207 4.7775419
14A:A:F212 4.396519
15A:A:V214 5.7175416
16A:A:D215 6.16415
17A:A:V217 4.698515
18A:A:F219 5.93833618
19A:A:H220 6.4375417
20A:A:M221 3.82618
21A:A:F222 8.814517
22A:A:Q227 5.664519
23A:A:R228 8.07419
24A:A:E230 9.32419
25A:A:R231 6.3725419
26A:A:K233 5.57429719
27A:A:W234 8.185619
28A:A:C237 3.844518
29A:A:F238 6.5719
30A:A:I245 3.80333617
31A:A:F246 3.755409
32A:A:V247 3.91517
33A:A:V248 4.165427
34A:A:Y253 6.586508
35A:A:R265 7.584519
36A:A:L270 5.396526
37A:A:F273 4.985829
38A:A:W277 6.2475826
39A:A:W281 8.996515
40A:A:I288 4.762519
41A:A:L289 3.96429
42A:A:F290 5.55875819
43A:A:L291 3.60667628
44A:A:N292 4.37519
45A:A:K293 5.678519
46A:A:Q294 5.885426
47A:A:L296 4.56416
48A:A:F312 3.875628
49A:A:E314 2.7426
50A:A:F315 10.8575426
51A:A:Y318 6.504526
52A:A:P321 5.265405
53A:A:P326 3.875421
54A:A:E330 4.68333623
55A:A:V334 2.142504
56A:A:K338 7.3725425
57A:A:Y339 5.35143723
58A:A:F340 8.57833627
59A:A:R342 5.81857724
60A:A:E344 6.916525
61A:A:F345 5.82167628
62A:A:L346 4.9424
63A:A:S349 4.556527
64A:A:R356 7.5625402
65A:A:C359 3.726525
66A:A:Y360 8.31286718
67A:A:H362 6.5725419
68A:A:F363 7.076525
69A:A:T364 5.734519
70A:A:D368 3.1575419
71A:A:N371 6.4225419
72A:A:R373 6.408515
73A:A:R374 5.874514
74A:A:F376 4.4825818
75A:A:D378 9.9875417
76A:A:C379 3.1225408
77A:A:D381 5.5225418
78A:A:I382 6.515416
79A:A:I383 4.212518
80A:A:R385 5.185415
81A:A:H387 5.558518
82A:A:Y391 6.8225814
83B:B:I18 4.2325407
84B:B:R22 7.9406
85B:B:V40 5.06413
86B:B:M45 3.586514
87B:B:R48 4.245417
88B:B:R49 5.125417
89B:B:L51 8.0925419
90B:B:H54 6.51375819
91B:B:K57 10.89519
92B:B:I58 4.376519
93B:B:Y59 12.096518
94B:B:M61 3.9575416
95B:B:W63 6.03875817
96B:B:S72 6.0575419
97B:B:Q75 11.505419
98B:B:D76 6.49833619
99B:B:K78 4.8175418
100B:B:L79 4.59667657
101B:B:I81 5.2775457
102B:B:W82 8.08143719
103B:B:N88 5.862567
104B:B:K89 5.94286719
105B:B:H91 6.345455
106B:B:I93 4.604557
107B:B:L95 4.576558
108B:B:W99 8.88167619
109B:B:M101 4.436519
110B:B:Y105 4.34429756
111B:B:N110 7.5875414
112B:B:Y111 6.01167614
113B:B:V112 4.9025458
114B:B:A113 2.3925419
115B:B:C114 4.034558
116B:B:G115 2.3275409
117B:B:L117 3.97619
118B:B:C121 3.352518
119B:B:I123 5.42416
120B:B:Y124 4.36875856
121B:B:V133 5.3575454
122B:B:L139 6.566509
123B:B:H142 6.27429719
124B:B:Y145 5.74778918
125B:B:L146 3.6825417
126B:B:C148 4.205436
127B:B:C149 3.448518
128B:B:R150 8.0525436
129B:B:F151 5.50333619
130B:B:L152 4.21433
131B:B:Q156 4.605405
132B:B:I157 6.405417
133B:B:V158 4.245435
134B:B:S160 3.838536
135B:B:S161 6.286519
136B:B:G162 4.5225419
137B:B:D163 8.4875419
138B:B:C166 3.452538
139B:B:L168 3.83436
140B:B:W169 9.55167618
141B:B:Q176 6.71414
142B:B:T178 4.29434
143B:B:F180 7.14637
144B:B:H183 7.06857739
145B:B:D186 6.56519
146B:B:V187 5.256539
147B:B:L190 4.508535
148B:B:L192 4.2975435
149B:B:R197 4.53405
150B:B:F199 5.79125839
151B:B:V200 8.27446
152B:B:S201 4.18539
153B:B:C204 4.362517
154B:B:D205 7.385439
155B:B:K209 10.505436
156B:B:L210 9.1525445
157B:B:W211 8.37333638
158B:B:R219 6.61445
159B:B:Q220 7.3225447
160B:B:F222 8.744548
161B:B:H225 7.08875849
162B:B:D228 7.19519
163B:B:I232 5.238548
164B:B:F234 6.0825405
165B:B:F235 6.7175816
166B:B:P236 7.785417
167B:B:F241 7.36429746
168B:B:T243 5.268548
169B:B:D247 10.27449
170B:B:T249 5.162546
171B:B:C250 3.105418
172B:B:R251 10.574548
173B:B:F253 7.29833646
174B:B:D254 4.175409
175B:B:L255 4.5525446
176B:B:R256 7.8775409
177B:B:D258 7.888547
178B:B:E260 7.805446
179B:B:Y264 6.755615
180B:B:H266 7.17414
181B:B:I269 4.57333614
182B:B:C271 4.03515
183B:B:I273 4.9425416
184B:B:V276 3.205416
185B:B:F278 5.69857717
186B:B:S281 4.4525419
187B:B:G282 3.684519
188B:B:R283 8.24167619
189B:B:L285 4.535616
190B:B:Y289 7.08857717
191B:B:D290 8.8425416
192B:B:D291 4.5175418
193B:B:N293 4.6625415
194B:B:C294 4.32415
195B:B:N295 8.318516
196B:B:V296 3.88167615
197B:B:W297 6.905618
198B:B:D298 7.248519
199B:B:L300 6.152516
200B:B:R304 7.91515
201B:B:G306 1.8475414
202B:B:L308 5.7975417
203B:B:H311 9.064519
204B:B:R314 11.9757718
205B:B:V315 4.188517
206B:B:C317 2.995407
207B:B:T321 6.835417
208B:B:M325 3.676515
209B:B:V327 5416
210B:B:T329 4.62833618
211B:B:G330 2.24405
212B:B:W332 12.4543719
213B:B:D333 8.4125419
214B:B:L336 5.6025417
215B:B:K337 7.456516
216B:B:I338 4.792515
217B:B:W339 7.742519
218G:G:Y40 7.8675416
219G:G:C41 4.565417
220G:G:D48 7.804519
221G:G:L50 4.005419
222G:G:L51 5.42616
223G:G:V54 3.895416
224G:G:N59 2.524519
225G:G:F61 6.67714718
226R:R:D18 4.55333616
227R:R:P22 5.005615
228R:R:Y26 5.23833618
229R:R:I30 3.98577
230R:R:G33 1.8625408
231R:R:V48 3.174585
232R:R:N52 6.3075407
233R:R:E53 7.566516
234R:R:L54 3.99333617
235R:R:V56 3.275486
236R:R:Y57 5.03507
237R:R:L58 4.964517
238R:R:L61 5.1475419
239R:R:Y68 6.61167605
240R:R:I69 3.485475
241R:R:L72 5.3975408
242R:R:W75 8.28429716
243R:R:Y78 8.228515
244R:R:F79 6.666514
245R:R:W85 6.81833619
246R:R:F99 10.8516
247R:R:Y100 6.57167615
248R:R:N102 5.76418
249R:R:Y104 7.74417
250R:R:I105 5.1475416
251R:R:F109 6.33333617
252R:R:L110 4.57518
253R:R:I113 5.382518
254R:R:D116 5.706518
255R:R:R117 5.11429719
256R:R:Y118 5.9725408
257R:R:V121 4.4625418
258R:R:L125 4.888515
259R:R:R126 3.54514
260R:R:F127 4.0275415
261R:R:R131 6.398517
262R:R:W144 4.32571719
263R:R:N151 4.275416
264R:R:P154 4.86516
265R:R:E159 5.5025414
266R:R:D163 4.5425411
267R:R:Y165 4.91412
268R:R:H167 8.48513
269R:R:F169 7.395612
270R:R:F171 9.878514
271R:R:E172 7.795615
272R:R:F174 9.51614
273R:R:M176 5.2475413
274R:R:W179 5.64625813
275R:R:N184 6.382515
276R:R:R187 7.346515
277R:R:V188 4.5475404
278R:R:F192 5.06618
279R:R:P195 4.685409
280R:R:Y203 5.5718
281R:R:S215 5.0275414
282R:R:T216 6.915413
283R:R:L231 5.094517
284R:R:V235 3.1525419
285R:R:F239 5.33819
286R:R:Y242 6.87286717
287R:R:H243 7.406518
288R:R:L246 7.745416
289R:R:Y253 4.38413
290R:R:F267 8.004514
291R:R:Y270 6.464514
292R:R:H271 11.8525414
293R:R:D284 6.74333619
294R:R:Y288 5.16857719
295R:R:C289 3.395416
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:R49 R:R:V48 99.75991.31NoYes065
2R:R:H51 R:R:R49 99.88031.13NoNo066
3B:B:F335 R:R:H51 1001.13NoNo046
4B:B:D333 B:B:F335 71.78267.17YesNo094
5B:B:D333 B:B:H311 68.60515.13YesYes199
6B:B:H311 B:B:T329 51.76866.85YesYes198
7B:B:G330 B:B:T329 38.35491.82YesYes058
8B:B:D76 B:B:H54 10.84262.52YesYes199
9A:A:F219 A:A:H41 35.48897.92YesYes186
10A:A:F219 A:A:L43 19.32672.44YesYes187
11A:A:I245 A:A:L43 18.94855.71YesYes177
12A:A:I245 A:A:L45 19.17822.85YesYes178
13A:A:K53 A:A:L45 38.05677.05YesYes198
14A:A:G47 A:A:K53 41.37921.74NoYes199
15A:A:G47 A:A:L46 46.18031.71NoYes198
16A:A:L44 A:A:L46 15.36935.54NoYes098
17A:A:F212 A:A:F219 20.022111.79YesYes198
18A:A:F212 A:A:M221 19.04242.49YesYes198
19A:A:L45 A:A:M221 19.14994.24YesYes188
20B:B:D76 B:B:G77 15.7093.35YesNo098
21A:A:H387 A:A:I383 38.77516.63YesYes188
22A:A:H387 A:A:Y391 37.8344.36YesYes184
23R:R:G55 R:R:L58 95.80055.13NoYes077
24R:R:G55 R:R:V48 95.90561.84NoYes075
25A:A:R231 A:A:W234 47.687911YesYes199
26A:A:I276 A:A:L46 20.65514.28NoYes188
27A:A:I276 A:A:R231 13.48852.51NoYes189
28B:B:M101 B:B:Y59 12.10027.18YesYes198
29B:B:W332 B:B:Y59 19.335613.5YesYes198
30B:B:S316 B:B:W332 21.32844.94NoYes099
31B:B:S147 B:B:Y145 12.51382.54NoYes098
32B:B:S147 B:B:S160 12.34344.89NoYes096
33A:A:K233 A:A:Q236 16.61024.07YesNo198
34A:A:D272 A:A:R231 13.81458.34NoYes089
35A:A:L282 A:A:N279 11.02198.24NoNo098
36A:A:N279 A:A:W281 11.10713.39NoYes085
37A:A:D272 A:A:F246 13.40322.39NoYes089
38A:A:F246 A:A:I276 33.89962.51YesNo098
39A:A:F246 A:A:V248 28.38732.62YesYes097
40A:A:F246 A:A:F273 18.5757.5YesYes099
41A:A:L291 A:A:V248 19.98114.47YesYes287
42A:A:F363 A:A:L291 10.92743.65YesYes258
43A:A:W281 B:B:D290 19.669410.05YesYes156
44B:B:C317 B:B:G330 10.71541.96YesYes075
45R:R:R117 R:R:Y288 36.39697.2YesYes199
46R:R:L58 R:R:Y288 90.07233.52YesYes179
47B:B:S281 G:G:D48 32.287510.31YesYes199
48B:B:G282 B:B:S281 31.30441.86YesYes199
49B:B:F278 B:B:G282 23.37094.52YesYes179
50B:B:C233 B:B:F278 28.87194.19NoYes137
51B:B:C233 B:B:S191 37.04261.72NoNo038
52B:B:F234 B:B:S191 36.65745.28YesNo058
53B:B:F234 B:B:V200 34.729810.49YesYes056
54B:B:F241 B:B:V200 24.209110.49YesYes466
55B:B:F222 B:B:F241 13.282912.86YesYes486
56B:B:D258 B:B:F222 12.14494.78YesYes478
57B:B:D258 B:B:R22 10.598111.91YesYes076
58B:B:T329 B:B:W339 17.73544.85YesYes189
59B:B:M45 B:B:W339 44.88973.49YesYes149
60B:B:C294 B:B:L308 10.97383.17YesYes157
61B:B:L308 B:B:V296 24.40982.98YesYes175
62B:B:L308 B:B:W339 14.070811.39YesYes179
63B:B:G306 B:B:V296 15.68521.84YesYes145
64G:G:D48 G:G:L50 35.97012.71YesYes199
65B:B:T47 B:B:W339 14.50419.7NoYes139
66B:B:H311 B:B:K337 14.74515.24YesYes196
67B:B:K337 B:B:T50 14.7187.51YesNo163
68B:B:K337 B:B:W339 28.7829.28YesYes169
69B:B:T47 B:B:T50 14.41783.14NoNo133
70B:B:F335 B:B:R52 28.58666.41NoNo047
71B:B:R52 B:B:T50 28.79569.06NoNo073
72B:B:G77 B:B:L95 14.52243.42NoYes088
73B:B:N125 B:B:Y111 10.58411.63NoYes044
74B:B:G162 B:B:Y145 12.2747.24YesYes198
75B:B:G162 B:B:S161 11.98693.71YesYes199
76B:B:F278 B:B:L285 14.043410.96YesYes176
77B:B:C271 B:B:D290 29.22343.11YesYes156
78B:B:C271 B:B:Y289 26.72044.03YesYes157
79B:B:W297 B:B:Y289 24.320710.61YesYes187
80B:B:L285 B:B:W297 23.77472.28YesYes168
81B:B:G306 B:B:V307 22.54561.84YesNo143
82B:B:N295 B:B:V307 19.29564.43YesNo163
83R:R:L110 R:R:Y288 50.00724.69YesYes189
84R:R:L110 R:R:V235 46.15052.98YesYes189
85R:R:F239 R:R:V235 47.49862.62YesYes199
86R:R:F239 R:R:H243 53.93172.26YesYes198
87R:R:H243 R:R:Y242 34.43188.71YesYes187
88R:R:Y100 R:R:Y242 21.28071.99YesYes157
89R:R:E172 R:R:Y100 15.53533.37YesYes155
90R:R:E172 R:R:F169 24.96468.16YesYes152
91R:R:D163 R:R:F169 21.60594.78YesYes112
92R:R:D163 R:R:Y165 10.8093.45YesYes112
93R:R:D284 R:R:Y288 74.34912.3YesYes199
94R:R:D284 R:R:N280 45.617513.46YesNo099
95R:R:F239 R:R:N280 45.49068.46YesNo099
96R:R:F239 R:R:T277 34.54275.19YesNo198
97R:R:T277 R:R:Y242 34.28514.99NoYes187
98R:R:D284 R:R:D65 25.01143.99YesNo099
99R:R:C281 R:R:D65 24.59593.11NoNo089
100R:R:C281 R:R:Y68 23.55654.03NoYes085
101R:R:F99 R:R:Y68 16.36679.28YesYes065
102R:R:Y242 R:R:Y270 34.624110.92YesYes174
103R:R:E172 R:R:Y270 12.47514.49YesYes154
104R:R:F174 R:R:Y270 18.55254.13YesYes144
105R:R:F169 R:R:F174 11.119411.79YesYes124
106R:R:F169 R:R:H167 15.122711.31YesYes123
107R:R:D83 R:R:H167 10.799612.61NoYes143
108R:R:D83 R:R:H82 11.12341.26NoNo144
109R:R:H243 R:R:Y104 13.31158.71YesYes187
110R:R:R187 R:R:Y104 10.516415.43YesYes157
111R:R:F171 R:R:Y100 10.19616.5YesYes145
112R:R:M176 R:R:N184 10.03432.8YesYes135
113R:R:L246 R:R:N184 10.340315.1YesYes165
114A:A:H41 A:A:I383 35.68885.3YesYes168
115A:A:K233 B:B:Y145 14.84623.58YesYes198
116B:B:L284 B:B:V296 14.98495.96NoYes155
117B:B:M45 G:G:L50 36.53542.83YesYes149
118A:A:W234 B:B:Y145 36.14895.79YesYes198
119B:B:G330 B:B:I58 24.06981.76YesYes059
120B:B:C317 B:B:S316 11.61923.44YesNo079
121A:A:L46 A:A:R231 20.85953.64YesYes189
122A:A:Y391 R:R:R117 34.8452.06YesYes149
123B:B:N295 B:B:W297 10.94634.52YesYes168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ZF9
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.56
Date 2025-02-26 
D.O.I. 10.1016/j.cell.2024.12.001
Net Summary
Imin 1.72
Number of Linked Nodes 867
Number of Links 1310
Number of Hubs 295
Number of Links mediated by Hubs 996
Number of Communities 9
Number of Nodes involved in Communities 421
Number of Links involved in Communities 756
Path Summary
Number Of Nodes in MetaPath 124
Number Of Links MetaPath 123
Number of Shortest Paths 4311331
Length Of Smallest Path 3
Average Path Length 24.6762
Length of Longest Path 46
Minimum Path Strength 1.13
Average Path Strength 5.48328
Maximum Path Strength 24.93
Minimum Path Correlation 0.7
Average Path Correlation 0.992151
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 46.4256
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 69.1502
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • nephron development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • epithelium development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ZF9_Chain_A
IEKQLQKDK QVYRATHRL LLLGASGKS TIVKQMRIH VVTSGIFET 
KFQVDKVNF HMFDVGQRD ERRKWIQCF NDVTAIIFV VSSYNRLQE 
ALNFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAGK SKIEDYFPE 
FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST ASGDGRHYC 
YPHFTCVDT ENRRFNDCR DIIQRMHLR QYELLTLSA EDKAAVERS 
KMDNYKADD DSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8ZF9_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8ZF9_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8BUD0
Sequence
>8ZF9_Chain_R
VDSRVDHLF PPSLYIFVI GVGLPTNCL ALWAAYRQV RQHNELGVY 
LMNLSIADL LYICTLPLW VDYFLHHDN WIHGPGSCK LFGFIFYSN 
IYISIAFLC CISVDRYLA VAHPLRFAR LRRVKTAVA VSSVVWATE 
LGANSAPLF HDELFRDRY NHTFCFEKF PMERWVAWM NLYRVFVGF 
LFPWALMLL CYRGILRAV QSSVSTERQ EKVKIKRLA LSLIAIVLV 
CFAPYHALL LSRSAVYLG RPWDCGFEE RVFSAYHSS LAFTSLNCV 
ADPILYCLV NEGARSDVA KALHN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-2610.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-2610.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-2610.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-2610.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-2610.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-2610.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-2610.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-2610.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-2610.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-2610.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-2610.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-2610.1016/j.cell.2024.12.001
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-2610.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-2610.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-2610.1016/j.cell.2024.12.001
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZFJAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.12024-08-07To be published
8ZFJ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.12024-08-07To be published
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-2610.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-2610.1016/j.cell.2024.12.001




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