Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 3.925439
2A:A:L30 2.835435
3A:A:H41 5.0375426
4A:A:L43 3.375407
5A:A:L45 4.8925408
6A:A:L46 4.7275418
7A:A:S51 2.8925429
8A:A:K53 4.4429
9A:A:I56 3.6975427
10A:A:M60 6.83429
11A:A:V214 3.675426
12A:A:F219 5.85857728
13A:A:M221 3.064528
14A:A:F222 7.56517
15A:A:Q227 6.47519
16A:A:R228 4.5125419
17A:A:R231 5.24519
18A:A:W234 8.645419
19A:A:C237 4.89418
20A:A:F238 8.3825419
21A:A:I244 3.9575418
22A:A:I245 3.18427
23A:A:V247 3.888527
24A:A:Y253 7.548336138
25A:A:R265 6.6685129
26A:A:L270 4.53406
27A:A:F273 5.49167699
28A:A:I276 3.65418
29A:A:W277 7.75167696
30A:A:N279 4.9675418
31A:A:W281 8.66415
32A:A:L282 5.6125419
33A:A:I288 4.762529
34A:A:L289 4.265499
35A:A:F290 6.56429729
36A:A:N292 4.622529
37A:A:Q294 4.284596
38A:A:L297 3.37754138
39A:A:E314 6.92754146
40A:A:F315 12.4725406
41A:A:Y318 6.525406
42A:A:V334 2.142504
43A:A:Y339 7.02593
44A:A:F340 8.7725147
45A:A:R342 6.355694
46A:A:E344 9.634145
47A:A:F345 5.962598
48A:A:S349 4.945497
49A:A:C359 4.4375495
50A:A:Y360 9.39833628
51A:A:F363 8.514595
52A:A:T364 8.7575429
53A:A:R374 7.04404
54A:A:I375 3.175429
55A:A:F376 5.1175428
56A:A:D378 10.5625427
57A:A:I383 4.868528
58A:A:R385 5.164525
59A:A:H387 6.21628
60A:A:Y391 11624
61B:B:I18 4.145407
62B:B:L30 5.405405
63B:B:V40 4.096563
64B:B:M45 3.586564
65B:B:L51 8.0925439
66B:B:H54 7.14143739
67B:B:K57 12.205419
68B:B:I58 5.03439
69B:B:Y59 12.632518
70B:B:M61 3.9575436
71B:B:W63 6.03875837
72B:B:S72 6.0575439
73B:B:Q75 12.2675419
74B:B:D76 7.338539
75B:B:K78 4.8175438
76B:B:L79 5.0485117
77B:B:I80 8.865438
78B:B:I81 5.27754117
79B:B:W82 9.075639
80B:B:N88 5.274537
81B:B:K89 4.70857739
82B:B:H91 6.62754115
83B:B:I93 4.6045117
84B:B:L95 4.5765118
85B:B:W99 7.67429719
86B:B:Y105 4.6856116
87B:B:N110 7.5875414
88B:B:Y111 6.01167614
89B:B:V112 4.90254118
90B:B:L117 4.155419
91B:B:C121 3.7375418
92B:B:I123 5.42416
93B:B:Y124 4.658577116
94B:B:V133 5.35754114
95B:B:L139 6.566509
96B:B:H142 6.46333619
97B:B:Y145 6.23918
98B:B:L146 3.86417
99B:B:C149 3.8575408
100B:B:F151 5.50333619
101B:B:L152 4.21483
102B:B:Q156 4.605405
103B:B:I157 6.405417
104B:B:V158 4.245485
105B:B:T159 6.7625419
106B:B:D163 8.4875419
107B:B:C166 3.885488
108B:B:W169 9.55167618
109B:B:D170 5.3954159
110B:B:Q176 6.71414
111B:B:F180 8.08587
112B:B:H183 7.89333689
113B:B:D186 6.3025419
114B:B:V187 5.256589
115B:B:L190 5.0275485
116B:B:L192 4.2975485
117B:B:L198 6.1875473
118B:B:F199 5.79125889
119B:B:V200 8.27476
120B:B:S201 4.18589
121B:B:C204 4.645417
122B:B:D205 7.385489
123B:B:K209 10.505486
124B:B:L210 9.1525475
125B:B:W211 9.624588
126B:B:Q220 7.3225477
127B:B:F222 8.744578
128B:B:H225 7.08875879
129B:B:D228 7.2125419
130B:B:I232 6.1075478
131B:B:F234 6.0825405
132B:B:F235 7.11714716
133B:B:P236 7.785417
134B:B:F241 8.185676
135B:B:T243 5.268578
136B:B:D247 10.27479
137B:B:T249 5.162576
138B:B:R251 10.574578
139B:B:F253 7.29833676
140B:B:D258 7.888577
141B:B:E260 7.805476
142B:B:Y264 6.755615
143B:B:H266 7.17414
144B:B:I269 4.57333614
145B:B:C271 4.03515
146B:B:I273 5.05406
147B:B:F278 5.69857717
148B:B:R283 6.464569
149B:B:L285 4.986516
150B:B:Y289 6.91571717
151B:B:D290 8.285416
152B:B:D291 6.2418
153B:B:C294 4.32465
154B:B:N295 9.952516
155B:B:V296 4.46505
156B:B:W297 7.83518
157B:B:L300 5.0145176
158B:B:R304 7.91515
159B:B:H311 8.904569
160B:B:R314 16.155418
161B:B:V315 4.466567
162B:B:M325 3.676535
163B:B:V327 5466
164B:B:T329 6.284568
165B:B:W332 13.1833619
166B:B:D333 9.1825469
167B:B:L336 5.6025437
168B:B:K337 7.718566
169B:B:I338 4.792535
170B:B:W339 8.652569
171G:G:Y40 7.8675416
172G:G:D48 7.804569
173G:G:L50 4.005469
174G:G:L51 5.825666
175G:G:V54 3.1825436
176G:G:N59 2.524539
177G:G:F61 6.67714738
178R:R:F21 3.6775406
179R:R:Y26 4.91333608
180R:R:L34 4.785456
181R:R:N37 7.014559
182R:R:N52 8.348527
183R:R:E53 9.44426
184R:R:L54 4.075407
185R:R:V56 3.2825446
186R:R:Y57 4.98507
187R:R:L58 3.484557
188R:R:L61 5.8675459
189R:R:D65 6.102559
190R:R:Y68 8.004505
191R:R:W75 12.298546
192R:R:Y78 7.81333645
193R:R:F79 7.7025404
194R:R:W85 9.19125849
195R:R:I98 4.922545
196R:R:F99 13.124546
197R:R:Y100 5.02667645
198R:R:N102 6.415448
199R:R:Y104 8.048507
200R:R:I105 7.8025446
201R:R:S106 2.97459
202R:R:F109 7.71167647
203R:R:L110 5.795658
204R:R:D116 7.7975428
205R:R:Y118 5.3085198
206R:R:P124 4.992528
207R:R:L125 4.79525
208R:R:R131 5.146527
209R:R:R132 5.324166
210R:R:S140 5.4125446
211R:R:W144 7.506549
212R:R:N151 5.57406
213R:R:H167 7.6025403
214R:R:E172 6.692545
215R:R:K173 7.094104
216R:R:F174 6.275404
217R:R:M176 6.09254103
218R:R:W179 9.4185103
219R:R:V180 6.1554105
220R:R:M183 4.4405
221R:R:N184 6.7885105
222R:R:V188 7.52754104
223R:R:W196 5.235405
224R:R:Y203 6.98558
225R:R:S215 5.31424
226R:R:T216 6.225423
227R:R:E220 4.4525425
228R:R:I224 3.62406
229R:R:V235 3.9375459
230R:R:F239 6.29667659
231R:R:Y242 6.21547
232R:R:H243 9.02408
233R:R:R249 13.354105
234R:R:S250 3.6985105
235R:R:F262 9.2525101
236R:R:H271 10.15544
237R:R:N280 6.9225459
238R:R:D284 7.33333659
239R:R:Y288 5.33571759
240R:R:D298 4.2425405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:S23 B:B:K89 10.20543.06NoYes379
2B:B:D76 B:B:L55 18.355712.21YesNo096
3A:A:Y37 B:B:L55 22.11565.86NoNo046
4A:A:R42 A:A:Y37 22.703411.32NoNo094
5A:A:F219 A:A:H41 86.13927.92YesYes286
6A:A:F219 A:A:L43 87.54124.87YesYes087
7A:A:I375 A:A:L43 1002.85YesYes097
8A:A:F290 A:A:I375 1002.51YesYes299
9A:A:F290 A:A:V247 89.46062.62YesYes297
10A:A:N292 A:A:V247 89.93574.43YesYes297
11A:A:K293 A:A:N292 1005.6NoYes099
12A:A:D249 A:A:K293 71.81298.3NoNo089
13A:A:D249 A:A:S251 71.71635.89NoNo089
14A:A:L297 A:A:S251 1003YesNo089
15A:A:L297 A:A:S250 1003YesNo086
16A:A:I341 A:A:S250 1004.64NoNo086
17A:A:F345 A:A:I341 1002.51YesNo088
18A:A:F345 A:A:V248 70.27556.55YesNo087
19A:A:F246 A:A:V248 70.17383.93NoNo097
20A:A:F246 A:A:I276 1002.51NoYes098
21A:A:I276 A:A:L46 48.87914.28YesYes188
22A:A:L44 A:A:L46 36.69996.92NoYes198
23A:A:F238 A:A:L44 36.557619.49YesNo199
24A:A:C237 A:A:F238 22.63512.79YesYes189
25A:A:C237 B:B:Y59 22.0888.06YesYes188
26B:B:W332 B:B:Y59 43.62113.5YesYes198
27B:B:S316 B:B:W332 39.11454.94NoYes099
28B:B:I58 B:B:S316 14.60983.1YesNo099
29A:A:H41 A:A:T242 85.96785.48YesNo068
30A:A:L43 A:A:T242 85.9712.95YesNo078
31A:A:F290 A:A:T364 89.356618.16YesYes299
32A:A:N292 A:A:T364 89.52615.85YesYes299
33A:A:K293 A:A:L296 1004.23NoNo096
34A:A:L296 A:A:S251 71.62643NoNo069
35A:A:F273 A:A:F345 70.85318.57YesYes998
36A:A:F246 A:A:F273 1005.36NoYes099
37A:A:D295 A:A:L296 36.15896.79NoNo096
38A:A:C365 A:A:D295 36.13766.22NoNo089
39A:A:C365 A:A:Q294 36.09543.05NoYes086
40A:A:L291 A:A:Q294 35.5342.66NoYes986
41A:A:L289 A:A:L291 35.64.15YesNo998
42A:A:F273 A:A:L289 35.43346.09YesYes999
43A:A:I276 A:A:R231 1006.26YesYes189
44A:A:R231 A:A:W234 66.59849YesYes199
45A:A:W234 B:B:Y145 65.58986.75YesYes198
46B:B:M101 B:B:Y145 22.51877.18NoYes198
47B:B:M101 B:B:Y59 22.37987.18NoYes198
48A:A:I235 A:A:R231 59.632.51NoYes199
49A:A:I235 A:A:N279 59.33665.66NoYes198
50A:A:N279 A:A:W281 59.06763.39YesYes185
51A:A:W281 B:B:R314 22.06447YesYes158
52B:B:R314 B:B:W332 21.833431.99YesYes189
53A:A:F238 A:A:V241 11.61235.24YesNo099
54A:A:R42 A:A:V241 22.93012.62NoNo099
55A:A:I244 A:A:L46 12.04462.85YesYes188
56A:A:I244 A:A:I285 11.7524.42YesNo187
57A:A:I285 A:A:V241 11.61633.07NoNo079
58A:A:H41 A:A:I383 1003.98YesYes268
59A:A:H387 A:A:I383 1006.63YesYes288
60A:A:H387 A:A:Q390 38.24043.71YesNo284
61A:A:H387 A:A:Y391 38.390111.98YesYes284
62A:A:H387 R:R:R131 94.17394.51YesYes287
63A:A:Q390 R:R:N52 38.093413.2NoYes247
64A:A:Y391 R:R:N52 38.0944.65YesYes247
65R:R:L54 R:R:N52 68.98994.12YesYes077
66R:R:D116 R:R:L54 34.51365.43YesYes087
67R:R:D116 R:R:R131 93.88373.57YesYes287
68A:A:E392 R:R:N292 15.027214.46NoNo068
69B:B:K209 B:B:T221 10.910112.01YesNo067
70B:B:T221 G:G:E22 21.43547.06NoNo079
71B:B:I18 G:G:E22 21.13815.47YesNo079
72B:B:S147 B:B:Y145 31.38222.54NoYes098
73B:B:S147 B:B:S160 31.23514.89NoNo096
74B:B:S160 B:B:V187 25.19444.85NoYes069
75B:B:H183 B:B:V187 22.97299.69YesYes899
76B:B:H183 B:B:K209 11.561313.1YesYes896
77B:B:H183 B:B:S207 10.97042.79YesNo895
78B:B:S207 B:B:T221 10.82263.2NoNo057
79B:B:I18 B:B:R22 16.67735.01YesNo076
80B:B:D258 B:B:R22 15.487311.91YesNo076
81B:B:N237 G:G:Y40 11.5694.65NoYes056
82B:B:N237 B:B:N239 10.679212.26NoNo052
83B:B:N313 B:B:W332 25.45975.65NoYes079
84B:B:D312 B:B:N313 25.02065.39NoNo057
85B:B:D312 B:B:D333 24.582514.64NoYes059
86B:B:C317 B:B:M61 23.63474.86NoYes076
87B:B:G162 B:B:Y145 10.22887.24NoYes198
88B:B:G162 B:B:S161 10.08443.71NoNo199
89B:B:D258 B:B:F222 11.02074.78YesYes778
90B:B:C271 B:B:D290 36.88883.11YesYes156
91B:B:C271 B:B:Y289 35.1074.03YesYes157
92B:B:I273 B:B:Y289 10.47513.63YesYes067
93B:B:I273 B:B:V276 10.03054.61YesNo066
94B:B:F235 B:B:F278 18.570311.79YesYes167
95B:B:F278 B:B:L285 18.886110.96YesYes176
96B:B:W297 B:B:Y289 23.746110.61YesYes187
97B:B:W297 B:B:Y264 23.615215.43YesYes185
98B:B:D333 B:B:H311 19.76267.56YesYes699
99R:R:D116 R:R:Y57 59.26879.2YesYes087
100R:R:C112 R:R:Y57 28.50984.03NoYes067
101R:R:C112 R:R:F109 28.36072.79NoYes067
102R:R:F109 R:R:I105 54.32677.54YesYes476
103R:R:I105 R:R:N102 53.74814.25YesYes468
104R:R:N102 R:R:Y68 45.955311.63YesYes085
105R:R:F99 R:R:Y68 27.71418.25YesYes065
106R:R:S140 R:R:Y57 29.86512.54YesYes067
107R:R:F109 R:R:S140 28.36983.96YesYes476
108R:R:F79 R:R:Y26 15.34653.09YesYes048
109R:R:F79 R:R:H271 12.641810.18YesYes044
110R:R:F99 R:R:Y100 10.84289.28YesYes465
111R:R:L54 R:R:L58 93.6152.77YesYes077
112R:R:L58 R:R:Y288 90.93313.52YesYes579
113R:R:D284 R:R:Y288 45.54594.6YesYes599
114R:R:A295 R:R:N292 11.26533.13NoNo088
115R:R:A295 R:R:C289 10.51561.81NoNo086
116R:R:L110 R:R:Y288 40.97577.03YesYes589
117R:R:L110 R:R:N280 36.94722.75YesYes589
118R:R:F239 R:R:N280 72.08699.67YesYes599
119R:R:F192 R:R:F239 30.6315NoYes589
120R:R:F192 R:R:H243 29.739914.71NoYes088
121R:R:H243 R:R:Y104 15.3274.36YesYes087
122R:R:N151 R:R:Y104 10.81986.98YesYes067
123R:R:D284 R:R:N280 36.940712.12YesYes599
124R:R:F239 R:R:T277 32.46945.19YesNo098
125R:R:I103 R:R:T277 16.21614.56NoNo078
126R:R:I103 R:R:Y104 15.314415.71NoYes077
127R:R:T277 R:R:Y242 15.35594.99NoYes087
128R:R:R187 R:R:Y104 16.220110.29NoYes057
129R:R:H243 R:R:V188 13.52448.3YesYes084
130R:R:L246 R:R:V188 10.81894.47NoYes1064
131R:R:S273 R:R:Y242 14.42573.82NoYes077
132R:R:L245 R:R:S273 13.52326.01NoNo047
133R:R:L245 R:R:V266 12.62092.98NoNo045
134R:R:F262 R:R:V266 10.817814.42YesNo015
135R:R:H271 R:R:Y270 10.5433.27YesNo044
136B:B:H311 B:B:T329 11.426612.32YesYes698
137B:B:C317 B:B:S316 24.07283.44NoNo079
138A:A:W281 B:B:D290 37.12747.82YesYes156
139B:B:M61 B:B:W63 22.32144.65YesYes367
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9JVG
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.76
Date 2025-02-26 
D.O.I. 10.1016/j.cell.2024.12.001
Net Summary
Imin 2.51
Number of Linked Nodes 878
Number of Links 1187
Number of Hubs 240
Number of Links mediated by Hubs 830
Number of Communities 19
Number of Nodes involved in Communities 340
Number of Links involved in Communities 548
Path Summary
Number Of Nodes in MetaPath 140
Number Of Links MetaPath 139
Number of Shortest Paths 30993968
Length Of Smallest Path 3
Average Path Length 64
Length of Longest Path 59
Minimum Path Strength 1.275
Average Path Strength 8.0176
Maximum Path Strength 24.93
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 44.5937
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 128
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • regulation of cell adhesion   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • positive regulation of defense response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • circulatory system process   • vascular process in circulatory system   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • nephron development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • regulation of angiogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • angiogenesis involved in wound healing   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9JVG_Chain_A
IEKQLQKDK QVYRATHRL LLLGASGKS TIVKQMRIH VVTSGIFET 
KFQVDKVNF HMFDVGQRD ERRKWIQCF NDVTAIIFV VSSYNRLQE 
ALNFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAGK SKIEDYFPE 
FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST ASGDGRHYC 
YPHFTCVDT ENRRFNDCR DIIQRMHLR QYELLTLSA EDKAAVERS 
KMDNYKADD DSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JVG_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JVG_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8BUD0
Sequence
>9JVG_Chain_R
VDSRVDHLF PPSLYIFVI GVGLPTNCL ALWAAYRQV RQHNELGVY 
LMNLSIADL LYICTLPLW VDYFLHHDN WIHGPGSCK LFGFIFYSN 
IYISIAFLC CISVDRYLA VAHPLRFAR LRRVKTAVA VSSVVWATE 
LGANSAPLF HDELFRDRY NHTFCFEKF PMERWVAWM NLYRVFVGF 
LFPWALMLL CYRGILRAV QSSVSTERQ EKVKIKRLA LSLIAIVLV 
CFAPYHALL LSRSAVYLG RPWDCGFEE RVFSAYHSS LAFTSLNCV 
ADPILYCLV NEGARSDVA KALHNL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-2610.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-2610.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-2610.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-2610.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-2610.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-2610.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-2610.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-2610.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-2610.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-2610.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-2610.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-2610.1016/j.cell.2024.12.001
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-2610.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-2610.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-2610.1016/j.cell.2024.12.001
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZFJAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.12024-08-07To be published
8ZFJ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.12024-08-07To be published
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-2610.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-2610.1016/j.cell.2024.12.001




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