Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:K34 2.99404
2A:A:H41 4.3425436
3A:A:L43 2.702537
4A:A:L45 6.3225458
5A:A:K53 6.955459
6A:A:F212 5.14439
7A:A:D215 3.4775435
8A:A:F219 5.30833638
9A:A:V224 4.0075419
10A:A:Q227 5.6375419
11A:A:K233 5.155619
12A:A:W234 5.88419
13A:A:C237 4.065418
14A:A:F238 4.945619
15A:A:F246 4.045409
16A:A:Y253 8.4225408
17A:A:L270 4.354546
18A:A:F273 4.6225179
19A:A:W277 7.477176
20A:A:W281 13.2675415
21A:A:I288 4.28333659
22A:A:F290 5.16559
23A:A:K293 8.45254169
24A:A:Q294 4.7925446
25A:A:Y311 4.625406
26A:A:F312 3.61333648
27A:A:F315 9.175446
28A:A:Y318 6.084546
29A:A:E330 7.4825443
30A:A:V334 2.305404
31A:A:K338 6.964545
32A:A:Y339 7.356543
33A:A:F340 11.91447
34A:A:R342 6.676544
35A:A:E344 6.78445
36A:A:F345 7.025408
37A:A:S349 3.4654177
38A:A:R356 7.7325402
39A:A:Y360 8.04333658
40A:A:H362 6.8225459
41A:A:F363 6.868545
42A:A:T364 5.278559
43A:A:D368 3.88459
44A:A:N371 5.296559
45A:A:R374 4.464554
46A:A:F376 4.686538
47A:A:I383 3.2775438
48A:A:R385 5.015185
49A:A:L388 3.2475408
50A:A:Y391 6.16286734
51B:B:L7 3.35754218
52B:B:L14 2.125408
53B:B:I37 2.7656102
54B:B:H54 8.53599
55B:B:K57 7.238519
56B:B:Y59 6.018518
57B:B:W63 5.796567
58B:B:S72 4.27499
59B:B:Q75 6.695419
60B:B:D76 6.6545199
61B:B:K78 2.89408
62B:B:W82 8.758599
63B:B:S84 4.4125465
64B:B:K89 6.20143799
65B:B:I93 3.92254137
66B:B:L95 3.4554138
67B:B:W99 6.65409
68B:B:M101 4.392519
69B:B:Y105 3.67333606
70B:B:Y111 4.485244
71B:B:L117 2.752519
72B:B:I123 2.93754246
73B:B:Y124 4.131676136
74B:B:V133 3.93754134
75B:B:H142 7.062519
76B:B:Y145 5.345818
77B:B:F151 4.53429709
78B:B:T159 4.7725409
79B:B:S161 7.805419
80B:B:D163 8.035419
81B:B:T165 3.2775417
82B:B:W169 9.014518
83B:B:D170 5.77754259
84B:B:T178 3.6404
85B:B:F180 8.8225487
86B:B:H183 7.00167689
87B:B:D186 5.0825419
88B:B:F199 5.656589
89B:B:V200 5.885476
90B:B:C204 4.086517
91B:B:D205 5.645489
92B:B:S207 3.0025485
93B:B:K209 8.158586
94B:B:W211 7.59688
95B:B:E215 6.5754263
96B:B:H225 6.9525879
97B:B:D228 7.058519
98B:B:I232 4.3925478
99B:B:F234 4.7325405
100B:B:F235 5.796258146
101B:B:P236 6.394147
102B:B:N237 7.8754145
103B:B:F241 5.595676
104B:B:T243 4.45167678
105B:B:D246 3.7725419
106B:B:D247 7.575479
107B:B:T249 4.358576
108B:B:R251 13.42478
109B:B:F253 7.236576
110B:B:D254 4.91409
111B:B:E260 7.8075476
112B:B:Y264 7.264505
113B:B:V276 1.705406
114B:B:F278 5.1954147
115B:B:R283 5.496676109
116B:B:L284 3.6665105
117B:B:Y289 5.766157
118B:B:V307 3.6554153
119B:B:H311 7.028336129
120B:B:R314 12.084518
121B:B:W332 9.485619
122B:B:D333 7.5554129
123B:B:K337 6.41754126
124B:B:W339 6.5425129
125G:G:I9 4.4325402
126G:G:R27 7.26754238
127G:G:M38 3.594104
128G:G:Y40 7.9154146
129G:G:D48 7.172509
130G:G:N59 3.9075469
131G:G:P60 5.85469
132G:G:F61 4.05167668
133R:R:D16 5.8325425
134R:R:F19 4.2405
135R:R:P20 4.206525
136R:R:Y24 4.61833629
137R:R:N35 5.115409
138R:R:N50 4.16537
139R:R:E51 7.29437
140R:R:L52 3.904538
141R:R:Y55 3.76507
142R:R:M57 2.87405
143R:R:Y66 5.568527
144R:R:T69 2.4775407
145R:R:L70 4.9675428
146R:R:W73 7.3825427
147R:R:Y76 7.716526
148R:R:F77 5.53525
149R:R:D81 5.32524
150R:R:W83 5.13625829
151R:R:H85 5.09527
152R:R:F97 7.0775427
153R:R:I103 3.824117
154R:R:F107 5.928336118
155R:R:D114 6.8675438
156R:R:R115 5.4725439
157R:R:Y116 4.1175438
158R:R:H121 4.3675436
159R:R:P122 3.87437
160R:R:L123 3.14436
161R:R:F125 4.2525436
162R:R:F167 5.468524
163R:R:F169 8.848504
164R:R:E170 5.5925424
165R:R:F172 4.864525
166R:R:M174 4.628521
167R:R:W177 8.795401
168R:R:N182 5.866525
169R:R:R185 5.24405
170R:R:Y201 5.188508
171R:R:T214 5.75254183
172R:R:E218 3.8965185
173R:R:L229 4.425408
174R:R:I230 2.8675407
175R:R:F237 5.812508
176R:R:Y240 5.466526
177R:R:L244 6.5225425
178R:R:R247 8424
179R:R:Y251 4.245403
180R:R:F265 8.382524
181R:R:H269 7.164525
182R:R:V280 2.45408
183R:R:D282 5.044119
184R:R:C287 2.15407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:H41 R:R:L123 22.88342.57YesYes366
2A:A:I383 R:R:L123 11.65144.28YesYes386
3A:A:H387 A:A:I383 24.48453.98NoYes388
4A:A:H387 R:R:R129 36.64995.64NoNo387
5A:A:Y391 R:R:R129 18.45984.12YesNo347
6A:A:Y391 R:R:N50 24.05883.49YesYes347
7R:R:N50 R:R:Q45 76.8362.64YesNo075
8R:R:Q45 R:R:Q48 1006.4NoNo057
9R:R:Q48 R:R:R44 99.98725.84NoNo074
10B:B:D312 R:R:R44 99.96072.38NoNo054
11B:B:D312 B:B:D333 99.94793.99NoYes059
12B:B:D333 B:B:H311 99.71687.56YesYes1299
13B:B:H311 B:B:T329 98.90885.48YesNo1298
14B:B:L318 B:B:T329 99.40132.95NoNo068
15B:B:L318 B:B:S275 56.24124.5NoNo068
16B:B:S275 B:B:T274 56.17524.8NoNo088
17B:B:R314 B:B:T274 55.48753.88YesNo188
18B:B:R314 B:B:W332 55.060915.99YesYes189
19B:B:S316 B:B:W332 28.90523.71NoYes099
20B:B:C317 B:B:S316 28.80543.44NoNo079
21B:B:C317 B:B:M61 28.66324.86NoNo076
22B:B:M61 B:B:W63 28.52082.33NoYes067
23B:B:S84 B:B:W63 26.67164.94YesYes657
24B:B:S84 G:G:F61 22.5346.61YesYes658
25G:G:F61 G:G:P60 18.56182.89YesYes689
26B:B:Y85 G:G:P60 49.62155.56NoYes049
27B:B:R68 B:B:Y85 49.316220.58NoNo054
28B:B:D83 B:B:R68 25.010311.91NoNo085
29R:R:L123 R:R:P122 11.60763.28YesYes367
30A:A:H387 R:R:P122 11.98763.05NoYes387
31R:R:E51 R:R:R129 18.376.98YesNo377
32R:R:E51 R:R:N50 23.98632.63YesYes377
33B:B:L318 B:B:S277 52.2743NoNo065
34B:B:S277 B:B:V320 52.19954.85NoNo057
35B:B:V320 B:B:V327 52.06123.21NoNo076
36B:B:L286 B:B:V327 52.37021.49NoNo076
37B:B:L286 B:B:V296 52.30081.49NoNo075
38B:B:L284 B:B:V296 39.86184.47YesNo055
39B:B:L284 B:B:S279 16.96073YesNo059
40B:B:S279 G:G:D48 16.89158.83NoYes099
41G:G:D48 G:G:P49 35.17873.22YesNo097
42B:B:M325 G:G:P49 35.01013.35NoNo057
43B:B:M325 G:G:P60 33.503210.06NoYes059
44B:B:L284 G:G:L51 16.95714.15YesNo1056
45G:G:D48 G:G:L51 18.793212.21YesNo096
46A:A:F219 A:A:H41 11.82827.92YesYes386
47A:A:L43 A:A:M221 14.17252.83YesNo078
48B:B:W332 B:B:Y59 36.80112.89YesYes198
49A:A:L45 A:A:M221 10.27667.07YesNo088
50A:A:I288 A:A:Y360 10.81214.84YesYes598
51A:A:I382 A:A:Y360 12.17138.46NoYes568
52A:A:I382 A:A:M386 12.55651.46NoNo063
53A:A:I383 A:A:M386 12.7471.46YesNo083
54B:B:M101 B:B:Y59 34.80615.99YesYes198
55R:R:R115 R:R:Y201 10.70697.2YesYes098
56R:R:L52 R:R:R115 11.17962.43YesYes389
57R:R:L52 R:R:N50 28.76854.12YesYes387
58B:B:M101 B:B:Y145 34.08684.79YesYes198
59A:A:W234 B:B:Y145 22.42774.82YesYes198
60A:A:R231 A:A:W234 22.56296NoYes099
61A:A:L272 A:A:R231 22.44044.86NoNo089
62A:A:F246 A:A:L272 22.31836.09YesNo098
63A:A:F246 A:A:L289 15.38993.65YesNo099
64A:A:Y391 R:R:D114 12.10385.75YesYes348
65R:R:D114 R:R:E51 12.0711.69YesYes387
66A:A:E392 R:R:Q45 24.473.82NoNo065
67A:A:E392 R:R:N290 24.38310.52NoNo068
68B:B:G306 B:B:V296 21.13491.84NoNo045
69B:B:G306 B:B:V307 21.00121.84NoYes043
70B:B:N295 B:B:V307 17.41724.43NoYes1563
71B:B:N295 B:B:Y289 17.292110.47NoYes1567
72B:B:I273 B:B:Y289 16.52087.25NoYes067
73B:B:G244 B:B:I273 15.98875.29NoNo056
74B:B:G244 B:B:T243 15.84911.82NoYes058
75B:B:D83 B:B:L69 23.9034.07NoNo085
76B:B:L69 B:B:Y105 46.96462.34NoYes056
77B:B:H62 B:B:Y105 28.6452.18NoYes066
78B:B:H62 B:B:R150 28.011412.41NoNo066
79B:B:D66 B:B:R68 24.00762.38NoNo085
80B:B:D66 B:B:L69 23.69655.43NoNo085
81B:B:V112 B:B:Y105 14.03282.52NoYes086
82B:B:V112 B:B:Y124 12.12262.52NoYes086
83B:B:G162 B:B:Y145 11.30497.24NoYes198
84B:B:G162 B:B:S161 11.21533.71NoYes199
85B:B:C148 B:B:R150 24.20662.79NoNo066
86B:B:C148 B:B:L190 23.5726.35NoNo065
87B:B:F199 B:B:L190 17.20462.44YesNo095
88R:R:D114 R:R:Y55 32.75134.6YesYes087
89R:R:S138 R:R:Y55 37.89442.54NoYes077
90R:R:F107 R:R:S138 36.92053.96YesNo1187
91R:R:F107 R:R:L59 31.65622.44YesNo1189
92R:R:D282 R:R:L59 31.30142.71YesNo1199
93R:R:D282 R:R:N278 34.51049.42YesNo099
94R:R:F237 R:R:N278 32.86987.25YesNo089
95R:R:F237 R:R:T275 23.22733.89YesNo088
96R:R:T275 R:R:Y240 22.82163.75NoYes086
97R:R:A293 R:R:N290 24.03564.69NoNo088
98R:R:A293 R:R:C287 23.95451.81NoYes087
99R:R:A38 R:R:C287 23.71481.81NoYes097
100R:R:A38 R:R:P283 22.99711.87NoNo099
101R:R:N35 R:R:P283 22.86468.15YesNo099
102R:R:D63 R:R:N35 11.59886.73NoYes099
103R:R:C279 R:R:D63 16.45916.22NoNo099
104R:R:C279 R:R:Y66 27.30375.38NoYes097
105R:R:F97 R:R:Y66 14.22618.25YesYes277
106R:R:F97 R:R:W73 13.137915.03YesYes277
107R:R:I67 R:R:N35 11.45232.83NoYes069
108R:R:C279 R:R:I67 11.25686.55NoNo096
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9BIP
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.8
Date 2025-01-22
D.O.I. doi.org/10.1016/j.cell.2024.11.036
Net Summary
Imin 2.38
Number of Linked Nodes 869
Number of Links 1082
Number of Hubs 184
Number of Links mediated by Hubs 660
Number of Communities 26
Number of Nodes involved in Communities 261
Number of Links involved in Communities 394
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 2096299
Length Of Smallest Path 3
Average Path Length 33.7144
Length of Longest Path 61
Minimum Path Strength 1.205
Average Path Strength 5.20205
Maximum Path Strength 21.49
Minimum Path Correlation 0.7
Average Path Correlation 0.984267
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 40.1778
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.2962
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein-containing complex binding   • binding   • G-protein beta/gamma-subunit complex binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyBiological Process
Gene OntologyCellular Component• protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • nephron development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • epithelium development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9BIP_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGASGKST 
IVKQMRILH TSGIFETKF QVDKVNFHM FDVGGQRDE RRKWIQCFN 
DVTAIIFVV SSYNRLQEA LNLFKSIWN NRWLRTISV ILFLNKQDL 
LAEKVLAGK SKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCAVD TENRRFNDC RDIIQRMHL 
RQYELLDNS GGDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9BIP_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWNG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9BIP_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9BIP_Chain_R
EGCHVDSRV DHLFPPSLY IFVIGVGLP TNCLALWAA YRQVQQRNE 
LGVYLMNLS IADLLYICT LPLWVDYFL HHDNWIHGP GSCKLFGFI 
FYTNIYISI AFLCCISVD RYLAVAHPL RFARLRRVK TAVAVSSVV 
WATELGANS APLFHDELF RDRYNHTFC FEKFPMEGW VAWMNLYRV 
FVGFLFPWA LMLLSYRGI LRAVRGSVS TERQEKAKI KRLALSLIA 
IVLVCFAPY HVLLLSRSA IYLGRPWDC GFEERVFSA YHSSLAFTS 
LNCVADPIL YCLVNEGAR SD


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-2610.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-2610.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-2610.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-2610.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-2610.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-2610.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-2610.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-2610.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-2610.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-2610.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-2610.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-2610.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-2610.1016/j.cell.2024.12.001
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-2610.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-2610.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-2610.1016/j.cell.2024.12.001
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZFJAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.12024-08-07To be published
8ZFJ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.12024-08-07To be published
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-2610.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-2610.1016/j.cell.2024.12.001




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