psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D20	R:R:N18	12.12	No	No	0	5	1
2	R:R:F273	R:R:V19	3.93	Yes	No	0	4	2
3	R:R:D20	R:R:E269	9.09	No	No	0	5	3
4	R:R:F273	R:R:S21	6.61	Yes	No	2	4	3
5	R:R:H277	R:R:S21	9.76	Yes	No	2	5	3
6	R:R:I23	R:R:N22	5.66	No	No	0	4	4
7	R:R:Q25	R:R:W81	4.38	No	Yes	0	5	6
8	R:R:H277	R:R:Q25	9.89	Yes	No	0	5	5
9	R:R:L78	R:R:Y32	11.72	No	Yes	0	7	8
10	R:R:W81	R:R:Y32	4.82	Yes	Yes	0	6	8
11	R:R:I82	R:R:Y32	4.84	No	Yes	0	7	8
12	R:R:A281	R:R:Y32	4	No	Yes	0	5	8
13	R:R:I34	R:R:L38	5.71	No	No	0	5	5
14	R:R:S284	R:R:V35	8.08	No	No	0	7	7
15	R:R:V288	R:R:V35	4.81	No	No	0	6	7
16	R:R:I36	R:R:L78	8.56	No	No	0	6	7
17	R:R:I36	R:R:P79	5.08	No	No	0	6	9
18	R:R:F40	R:R:I75	6.28	No	No	0	6	6
19	R:R:F40	R:R:T76	3.89	No	No	0	6	4
20	R:R:P291	R:R:T42	5.25	No	No	0	9	7
21	R:R:F296	R:R:T42	5.19	Yes	No	0	7	7
22	R:R:D71	R:R:N43	5.39	Yes	Yes	0	9	9
23	R:R:I75	R:R:N43	5.66	No	Yes	0	6	9
24	R:R:N43	R:R:P291	14.66	Yes	No	0	9	9
25	R:R:M45	R:R:V305	6.09	No	No	0	5	5
26	R:R:L309	R:R:M45	4.24	No	No	0	7	5
27	R:R:L47	R:R:S68	7.51	No	No	0	7	8
28	R:R:I69	R:R:L47	4.28	No	No	0	6	7
29	R:R:M52	R:R:W48	10.47	No	No	0	4	3
30	R:R:A308	R:R:W48	5.19	No	No	0	6	3
31	R:R:K55	R:R:Y51	10.75	No	No	0	6	3
32	R:R:D304	R:R:M52	11.09	No	No	0	5	4
33	R:R:Q53	R:R:Q56	5.12	No	No	0	4	6
34	R:R:N58	R:R:Q53	3.96	No	No	0	7	4
35	R:R:D304	R:R:Q53	3.92	No	No	0	5	4
36	R:R:I62	R:R:V54	7.68	Yes	No	0	7	5
37	R:R:L60	R:R:N58	4.12	Yes	No	0	7	7
38	R:R:D122	R:R:E59	11.69	No	No	0	8	6
39	R:R:E59	R:R:R137	6.98	No	No	0	6	6
40	R:R:L60	R:R:L64	5.54	Yes	No	1	7	8
41	R:R:I119	R:R:L60	4.28	Yes	Yes	1	9	7
42	R:R:D122	R:R:L60	4.07	No	Yes	0	8	7
43	R:R:L60	R:R:R123	4.86	Yes	Yes	1	7	9
44	R:R:G61	R:R:L64	5.13	No	No	0	7	8
45	R:R:A142	R:R:I62	4.87	No	Yes	0	8	7
46	R:R:I62	R:R:L143	4.28	Yes	No	0	7	2
47	R:R:C118	R:R:Y63	4.03	No	Yes	0	5	7
48	R:R:D122	R:R:Y63	9.2	No	Yes	0	8	7
49	R:R:A142	R:R:Y63	5.34	No	Yes	0	8	7
50	R:R:V145	R:R:Y63	3.79	No	Yes	0	5	7
51	R:R:I119	R:R:L64	4.28	Yes	No	1	9	8
52	R:R:F115	R:R:N66	15.71	Yes	No	4	7	9
53	R:R:N66	R:R:S146	8.94	No	No	4	9	7
54	R:R:N66	R:R:W150	4.52	No	No	4	9	9
55	R:R:D71	R:R:L67	5.43	Yes	No	5	9	9
56	R:R:L116	R:R:L67	5.54	No	No	0	8	9
57	R:R:D290	R:R:L67	9.5	No	No	5	9	9
58	R:R:D71	R:R:S112	4.42	Yes	No	0	9	9
59	R:R:C287	R:R:D71	4.67	No	Yes	0	8	9
60	R:R:D290	R:R:D71	10.65	No	Yes	5	9	9
61	R:R:L73	R:R:N108	8.24	No	Yes	0	6	8
62	R:R:L78	R:R:Y74	4.69	No	No	0	7	6
63	R:R:N108	R:R:Y74	4.65	Yes	No	0	8	6
64	R:R:S284	R:R:Y74	3.82	No	No	0	7	6
65	R:R:C287	R:R:I75	6.55	No	No	0	8	6
66	R:R:F101	R:R:T77	6.49	Yes	No	0	5	6
67	R:R:I104	R:R:T77	4.56	No	No	0	4	6
68	R:R:L100	R:R:L80	4.15	No	No	0	5	7
69	R:R:F101	R:R:L80	6.09	Yes	No	0	5	7
70	R:R:F85	R:R:W81	10.02	No	Yes	0	5	6
71	R:R:F101	R:R:W81	4.01	Yes	Yes	0	5	6
72	R:R:D83	R:R:Y84	5.75	No	No	0	4	5
73	R:R:D83	R:R:H87	7.56	No	No	0	4	4
74	R:R:H88	R:R:Y84	11.98	No	No	0	4	5
75	R:R:H87	R:R:V86	4.15	No	No	0	4	4
76	R:R:H87	R:R:H88	5.97	No	No	0	4	4
77	R:R:C176	R:R:C98	5.46	No	No	0	9	9
78	R:R:K99	R:R:L161	8.46	No	No	0	7	4
79	R:R:F101	R:R:G102	6.02	Yes	No	0	5	6
80	R:R:F103	R:R:T107	3.89	No	Yes	6	5	5
81	R:R:F103	R:R:I154	6.28	No	No	6	5	4
82	R:R:F103	R:R:L161	7.31	No	No	0	5	4
83	R:R:I104	R:R:N108	5.66	No	Yes	0	4	8
84	R:R:F105	R:R:Y106	11.35	No	Yes	0	6	5
85	R:R:F105	R:R:I109	5.02	No	No	0	6	7
86	R:R:F105	R:R:L280	7.31	No	No	0	6	5
87	R:R:Y106	R:R:Y110	3.97	Yes	Yes	7	5	7
88	R:R:E178	R:R:Y106	6.73	No	Yes	0	5	5
89	R:R:R193	R:R:Y106	22.64	Yes	Yes	7	5	5
90	R:R:N108	R:R:T107	5.85	Yes	Yes	0	8	5
91	R:R:I154	R:R:T107	4.56	No	Yes	6	4	5
92	R:R:N157	R:R:T107	5.85	No	Yes	0	7	5
93	R:R:I109	R:R:Y110	6.04	No	Yes	0	7	7
94	R:R:F245	R:R:I109	6.28	Yes	No	0	8	7
95	R:R:R193	R:R:Y110	11.32	Yes	Yes	7	5	7
96	R:R:H249	R:R:Y110	15.24	Yes	Yes	0	8	7
97	R:R:V111	R:R:W150	12.26	No	No	0	7	9
98	R:R:F245	R:R:I113	16.33	Yes	No	0	8	7
99	R:R:F115	R:R:S146	6.61	Yes	No	4	7	7
100	R:R:F115	R:R:V149	11.8	Yes	No	0	7	6
101	R:R:F115	R:R:W150	9.02	Yes	No	4	7	9
102	R:R:L116	R:R:Y294	5.86	No	Yes	0	8	9
103	R:R:C117	R:R:I204	4.91	No	No	0	7	6
104	R:R:I119	R:R:R123	7.52	Yes	Yes	1	9	9
105	R:R:I119	R:R:Y294	8.46	Yes	Yes	1	9	9
106	R:R:M205	R:R:S120	6.13	No	No	0	7	9
107	R:R:S120	R:R:Y209	10.17	No	Yes	0	9	9
108	R:R:R123	R:R:Y209	8.23	Yes	Yes	1	9	9
109	R:R:R123	R:R:Y294	8.23	Yes	Yes	1	9	9
110	R:R:A128	R:R:Y124	8.01	No	Yes	3	7	7
111	R:R:H129	R:R:Y124	9.8	Yes	Yes	3	6	7
112	R:R:F133	R:R:L125	4.87	No	No	0	5	5
113	R:R:A128	R:R:H129	7.32	No	Yes	3	7	6
114	R:R:H129	R:R:K132	6.55	Yes	No	3	6	4
115	R:R:F133	R:R:H129	6.79	No	Yes	3	5	6
116	R:R:F133	R:R:K132	6.2	No	No	3	5	4
117	R:R:K140	R:R:R138	8.66	No	No	0	4	6
118	R:R:R138	R:R:T141	6.47	No	No	0	6	4
119	R:R:E153	R:R:N157	6.57	No	No	0	7	7
120	R:R:A156	R:R:Y192	4	No	No	0	4	3
121	R:R:F162	R:R:S158	3.96	No	No	0	4	5
122	R:R:F162	R:R:L161	9.74	No	No	0	4	4
123	R:R:H163	R:R:W185	8.46	No	No	0	4	1
124	R:R:K179	R:R:P181	6.69	No	No	0	4	5
125	R:R:V186	R:R:Y180	3.79	No	Yes	0	4	4
126	R:R:A187	R:R:Y180	4	No	Yes	0	4	4
127	R:R:R255	R:R:Y180	7.2	No	Yes	0	4	4
128	R:R:F259	R:R:M182	9.95	No	No	0	3	2
129	R:R:E183	R:R:V186	11.41	No	No	0	3	4
130	R:R:F259	R:R:P184	7.22	No	No	0	3	3
131	R:R:M189	R:R:Y192	4.79	No	No	0	5	3
132	R:R:M189	R:R:R193	7.44	No	Yes	0	5	5
133	R:R:N190	R:R:R193	6.03	No	Yes	0	5	5
134	R:R:L252	R:R:N190	16.48	No	No	0	6	5
135	R:R:L196	R:R:Y192	7.03	No	No	0	4	3
136	R:R:H249	R:R:T194	4.11	Yes	No	0	8	5
137	R:R:L252	R:R:T194	4.42	No	No	0	6	5
138	R:R:L253	R:R:T194	5.9	No	No	0	5	5
139	R:R:G197	R:R:P201	4.06	No	Yes	0	5	9
140	R:R:F198	R:R:W202	8.02	No	Yes	0	8	6
141	R:R:F198	R:R:H249	10.18	No	Yes	0	8	8
142	R:R:V241	R:R:W202	4.9	No	Yes	0	9	6
143	R:R:L242	R:R:W202	20.5	No	Yes	0	5	6
144	R:R:M205	R:R:V241	4.56	No	No	0	7	9
145	R:R:I238	R:R:L206	4.28	No	No	0	7	4
146	R:R:A234	R:R:Y209	4	No	Yes	0	7	9
147	R:R:L237	R:R:Y209	7.03	No	Yes	1	7	9
148	R:R:I238	R:R:Y209	7.25	No	Yes	0	7	9
149	R:R:Y209	R:R:Y294	4.96	Yes	Yes	1	9	9
150	R:R:K231	R:R:L213	7.05	No	No	0	6	4
151	R:R:A234	R:R:L213	4.73	No	No	0	7	4
152	R:R:R214	R:R:R217	5.33	No	No	0	4	4
153	R:R:K227	R:R:V216	4.55	No	No	0	6	8
154	R:R:I230	R:R:V216	6.14	No	No	0	7	8
155	R:R:N219	R:R:T222	8.77	No	No	0	5	4
156	R:R:K227	R:R:T222	9.01	No	No	0	6	4
157	R:R:Q225	R:R:R224	8.18	No	No	0	4	3
158	R:R:K231	R:R:L235	4.23	No	No	0	6	4
159	R:R:L233	R:R:V297	4.47	No	No	0	7	7
160	R:R:L237	R:R:L293	6.92	No	Yes	0	7	7
161	R:R:L237	R:R:Y294	14.07	No	Yes	1	7	9
162	R:R:I240	R:R:L293	8.56	No	Yes	0	7	7
163	R:R:F245	R:R:H249	5.66	Yes	Yes	0	8	8
164	R:R:F245	R:R:T283	3.89	Yes	No	0	8	7
165	R:R:F245	R:R:N286	13.29	Yes	No	0	8	9
166	R:R:L282	R:R:P247	4.93	No	No	0	6	9
167	R:R:H249	R:R:Y248	7.62	Yes	Yes	0	8	7
168	R:R:L252	R:R:Y248	4.69	No	Yes	0	6	7
169	R:R:Y248	R:R:Y276	6.95	Yes	Yes	2	7	5
170	R:R:T279	R:R:Y248	7.49	Yes	Yes	0	6	7
171	R:R:L280	R:R:Y248	9.38	No	Yes	2	5	7
172	R:R:L272	R:R:W254	12.53	No	No	0	5	4
173	R:R:R255	R:R:Y276	9.26	No	Yes	0	4	5
174	R:R:C266	R:R:L258	6.35	Yes	No	0	5	3
175	R:R:N262	R:R:P263	4.89	No	No	0	1	2
176	R:R:D265	R:R:N262	6.73	No	No	0	4	1
177	R:R:C266	R:R:N262	6.3	Yes	No	0	5	1
178	R:R:C266	R:R:G267	3.92	Yes	No	0	5	1
179	R:R:E269	R:R:F273	16.32	No	Yes	0	3	4
180	R:R:E270	R:R:N271	6.57	No	No	0	4	2
181	R:R:F273	R:R:H277	5.66	Yes	Yes	2	4	5
182	R:R:H277	R:R:Y276	10.89	Yes	Yes	2	5	5
183	R:R:L280	R:R:Y276	4.69	No	Yes	2	5	5
184	R:R:D290	R:R:N286	13.46	No	No	0	9	9
185	R:R:C295	R:R:F296	4.19	Yes	Yes	0	6	7
186	R:R:F296	R:R:V305	3.93	Yes	No	0	7	5
187	R:R:E299	R:R:H303	7.39	No	No	0	5	5
188	R:R:H303	R:R:R307	4.51	No	No	0	5	5
189	R:R:F296	R:R:I292	3.77	Yes	No	0	7	6
190	R:R:F198	R:R:L199	3.65	No	No	0	8	4
191	R:R:I212	R:R:Y124	3.63	No	Yes	0	8	7
192	R:R:A46	R:R:C295	3.61	No	Yes	0	8	6
193	R:R:F27	R:R:Q28	3.51	No	No	0	5	5
194	R:R:P247	R:R:T279	3.5	No	Yes	0	9	6
195	R:R:C176	R:R:S97	3.44	No	No	0	9	5
196	R:R:A208	R:R:S120	3.42	No	No	0	6	9
197	R:R:A70	R:R:V111	3.39	No	No	0	8	7
198	R:R:I113	R:R:P201	3.39	No	Yes	0	7	9
199	R:R:E299	R:R:G300	3.27	No	No	0	5	6
200	R:R:C264	R:R:M182	3.24	No	No	0	3	2
201	R:R:A50	R:R:M65	3.22	No	No	0	6	6
202	R:R:A159	R:R:M189	3.22	No	No	0	8	5
203	R:R:C44	R:R:L72	3.17	No	No	0	3	7
204	R:R:A281	R:R:L31	3.15	No	No	0	5	5
205	R:R:A246	R:R:L242	3.15	No	No	0	5	5
206	R:R:C244	R:R:N286	3.15	No	No	0	7	9
207	R:R:E183	R:R:P184	3.14	No	No	0	3	3
208	R:R:I34	R:R:V37	3.07	No	No	0	5	4
209	R:R:I212	R:R:V127	3.07	No	No	0	8	7
210	R:R:L253	R:R:S256	3	No	No	0	5	5
211	R:R:L38	R:R:V288	2.98	No	No	0	5	6
212	R:R:L125	R:R:V121	2.98	No	No	0	5	6
213	R:R:L125	R:R:V136	2.98	No	No	0	5	3
214	R:R:L253	R:R:V257	2.98	No	No	0	5	3
215	R:R:L251	R:R:T279	2.95	No	Yes	0	5	6
216	R:R:I62	R:R:M65	2.92	Yes	No	0	7	6
217	R:R:G211	R:R:Y124	2.9	No	Yes	0	4	7
218	R:R:K55	R:R:M52	2.88	No	No	0	6	4
219	R:R:E153	R:R:V111	2.85	No	No	0	7	7
220	R:R:I261	R:R:L260	2.85	No	No	0	2	1
221	R:R:L47	R:R:M65	2.83	No	No	0	7	6
222	R:R:A126	R:R:R137	2.77	No	No	0	8	6
223	R:R:L282	R:R:L285	2.77	No	No	0	6	5
224	R:R:L72	R:R:N43	2.75	No	Yes	0	7	9
225	R:R:A208	R:R:Y124	2.67	No	Yes	0	6	7
226	R:R:L31	R:R:Q28	2.66	No	No	0	5	5
227	R:R:F101	R:R:S97	2.64	Yes	No	0	5	5
228	R:R:F85	R:R:V86	2.62	No	No	0	5	4
229	R:R:E223	R:R:E226	2.54	No	No	0	4	5
230	R:R:F195	R:R:L196	2.44	No	No	0	4	4
231	R:R:L272	R:R:R255	2.43	No	No	0	5	4
232	R:R:E183	R:R:W185	2.18	No	No	0	3	1
233	R:R:F26	R:R:F27	2.14	No	No	0	4	5
234	R:R:R210	R:R:R214	2.13	No	No	0	3	4
235	R:R:G267	R:R:G268	2.11	No	No	0	1	2
236	R:R:G39	R:R:P41	2.03	No	No	0	8	5
237	R:R:C117	R:R:P201	1.88	No	Yes	0	7	9
238	R:R:A159	R:R:P160	1.87	No	No	0	8	4
239	R:R:A200	R:R:P201	1.87	No	Yes	0	4	9
240	R:R:G39	R:R:V288	1.84	No	No	0	8	6
241	R:R:A49	R:R:C295	1.81	No	Yes	0	7	6
242	R:R:A301	R:R:C295	1.81	No	Yes	0	7	6
243	R:R:A128	R:R:A215	1.79	No	No	0	7	5
244	R:R:G188	R:R:L191	1.71	No	No	0	4	4
245	R:R:A114	R:R:V149	1.7	No	No	0	5	6
246	R:R:G300	R:R:N298	1.7	No	No	0	6	8
247	R:R:L131	R:R:P130	1.64	No	No	0	5	8
248	R:R:C266	R:R:M182	1.62	Yes	No	0	5	2
249	R:R:A289	R:R:I240	1.62	No	No	0	6	7
250	R:R:V127	R:R:V216	1.6	No	No	0	7	8
251	R:R:T141	R:R:V136	1.59	No	No	0	4	3
252	R:R:T141	R:R:V145	1.59	No	No	0	4	5
253	R:R:G274	R:R:H277	1.59	No	Yes	0	2	5
254	R:R:T279	R:R:V278	1.59	Yes	No	0	6	5
255	R:R:A275	R:R:L251	1.58	No	No	0	5	5
256	R:R:I62	R:R:V139	1.54	Yes	No	0	7	4
257	R:R:H129	R:R:P130	1.53	Yes	No	0	6	8
258	R:R:I33	R:R:T30	1.52	No	No	0	5	5
259	R:R:K57	R:R:V139	1.52	No	No	0	6	4
260	R:R:K99	R:R:V96	1.52	No	No	0	7	1
261	R:R:G211	R:R:R214	1.5	No	No	0	4	4
262	R:R:L293	R:R:S236	1.5	Yes	No	0	7	5
263	R:R:N219	R:R:S221	1.49	No	No	0	5	4
264	R:R:L293	R:R:V297	1.49	Yes	No	0	7	7
265	R:R:I33	R:R:I82	1.47	No	No	0	5	7
266	R:R:I238	R:R:L239	1.43	No	No	0	7	3
267	R:R:E153	R:R:T152	1.41	No	No	0	7	4
268	R:R:G203	R:R:W202	1.41	No	Yes	0	3	6
269	R:R:P181	R:R:Y180	1.39	No	Yes	0	5	4
270	R:R:A134	R:R:R137	1.38	No	No	0	5	6
271	R:R:L242	R:R:L243	1.38	No	No	0	5	6
272	R:R:L309	R:R:L312	1.38	No	No	0	7	3
273	R:R:E223	R:R:Q225	1.27	No	No	0	4	4
274	R:R:K135	R:R:R138	1.24	No	No	0	4	6
275	R:R:K229	R:R:R232	1.24	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y32	6.345	4	0	8
2	R:R:N43	7.115	4	0	9
3	R:R:L60	4.574	5	1	7
4	R:R:I62	4.258	5	0	7
5	R:R:Y63	5.59	4	0	7
6	R:R:D71	6.112	5	5	9
7	R:R:W81	5.8075	4	0	6
8	R:R:F101	5.05	5	0	5
9	R:R:Y106	11.1725	4	7	5
10	R:R:T107	5.0375	4	6	5
11	R:R:N108	6.1	4	0	8
12	R:R:Y110	9.1425	4	7	7
13	R:R:F115	10.785	4	4	7
14	R:R:I119	6.135	4	1	9
15	R:R:R123	7.21	4	1	9
16	R:R:Y124	5.402	5	3	7
17	R:R:H129	6.398	5	3	6
18	R:R:Y180	4.095	4	0	4
19	R:R:R193	11.8575	4	7	5
20	R:R:P201	2.8	4	0	9
21	R:R:W202	8.7075	4	0	6
22	R:R:Y209	6.94	6	1	9
23	R:R:F245	9.09	5	0	8
24	R:R:Y248	7.226	5	2	7
25	R:R:H249	8.562	5	0	8
26	R:R:C266	4.5475	4	0	5
27	R:R:F273	8.13	4	2	4
28	R:R:Y276	7.9475	4	2	5
29	R:R:H277	7.558	5	2	5
30	R:R:T279	3.8825	4	0	6
31	R:R:L293	4.6175	4	0	7
32	R:R:Y294	8.316	5	1	9
33	R:R:C295	2.855	4	0	6
34	R:R:F296	4.27	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H277	R:R:Q25	86.6004	9.89	Yes	No	0	5	5
2	R:R:Q25	R:R:W81	85.8441	4.38	No	Yes	0	5	6
3	R:R:W81	R:R:Y32	46.9379	4.82	Yes	Yes	0	6	8
4	R:R:L78	R:R:Y32	38.2171	11.72	No	Yes	0	7	8
5	R:R:L78	R:R:Y74	35.1438	4.69	No	No	0	7	6
6	R:R:S284	R:R:Y74	10.1885	3.82	No	No	0	7	6
7	R:R:H277	R:R:Y276	92.2925	10.89	Yes	Yes	2	5	5
8	R:R:Y248	R:R:Y276	100	6.95	Yes	Yes	2	7	5
9	R:R:H249	R:R:Y248	99.7243	7.62	Yes	Yes	0	8	7
10	R:R:F245	R:R:H249	63.2469	5.66	Yes	Yes	0	8	8
11	R:R:F245	R:R:N286	67.6911	13.29	Yes	No	0	8	9
12	R:R:D290	R:R:N286	67.4005	13.46	No	No	0	9	9
13	R:R:D290	R:R:D71	15.9626	10.65	No	Yes	5	9	9
14	R:R:D71	R:R:N43	19.7884	5.39	Yes	Yes	0	9	9
15	R:R:N43	R:R:P291	13.4294	14.66	Yes	No	0	9	9
16	R:R:P291	R:R:T42	12.3305	5.25	No	No	0	9	7
17	R:R:F296	R:R:T42	11.2167	5.19	Yes	No	0	7	7
18	R:R:F198	R:R:H249	48.6924	10.18	No	Yes	0	8	8
19	R:R:F198	R:R:W202	47.9996	8.02	No	Yes	0	8	6
20	R:R:V241	R:R:W202	46.1742	4.9	No	Yes	0	9	6
21	R:R:M205	R:R:V241	45.8836	4.56	No	No	0	7	9
22	R:R:M205	R:R:S120	45.6825	6.13	No	No	0	7	9
23	R:R:S120	R:R:Y209	34.6856	10.17	No	Yes	0	9	9
24	R:R:R123	R:R:Y209	23.5993	8.23	Yes	Yes	1	9	9
25	R:R:L60	R:R:R123	47.7462	4.86	Yes	Yes	1	7	9
26	R:R:D122	R:R:L60	52.0526	4.07	No	Yes	0	8	7
27	R:R:D122	R:R:Y63	41.1004	9.2	No	Yes	0	8	7
28	R:R:A142	R:R:Y63	26.3858	5.34	No	Yes	0	8	7
29	R:R:A142	R:R:I62	24.024	4.87	No	Yes	0	8	7
30	R:R:I62	R:R:M65	12.1033	2.92	Yes	No	0	7	6
31	R:R:D290	R:R:L67	51.2852	9.5	No	No	5	9	9
32	R:R:L116	R:R:L67	61.2092	5.54	No	No	0	8	9
33	R:R:L116	R:R:Y294	60.8777	5.86	No	Yes	0	8	9
34	R:R:R123	R:R:Y294	25.7525	8.23	Yes	Yes	1	9	9
35	R:R:I119	R:R:Y294	27.7902	8.46	Yes	Yes	1	9	9
36	R:R:I119	R:R:L60	25.2012	4.28	Yes	Yes	1	9	7
37	R:R:L60	R:R:N58	20.7383	4.12	Yes	No	0	7	7
38	R:R:N58	R:R:Q53	18.4063	3.96	No	No	0	7	4
39	R:R:D304	R:R:Q53	13.7163	3.92	No	No	0	5	4
40	R:R:D304	R:R:M52	11.6115	11.09	No	No	0	5	4
41	R:R:V145	R:R:Y63	12.7068	3.79	No	Yes	0	5	7
42	R:R:N108	R:R:Y74	25.7897	4.65	Yes	No	0	8	6
43	R:R:N108	R:R:T107	45.608	5.85	Yes	Yes	0	8	5
44	R:R:N157	R:R:T107	27.8014	5.85	No	Yes	0	7	5
45	R:R:E153	R:R:N157	25.5253	6.57	No	No	0	7	7
46	R:R:E153	R:R:V111	20.9507	2.85	No	No	0	7	7
47	R:R:V111	R:R:W150	16.3463	12.26	No	No	0	7	9
48	R:R:F101	R:R:W81	34.0747	4.01	Yes	Yes	0	5	6
49	R:R:F101	R:R:T77	26.952	6.49	Yes	No	0	5	6
50	R:R:I104	R:R:T77	25.9276	4.56	No	No	0	4	6
51	R:R:I104	R:R:N108	24.9404	5.66	No	Yes	0	4	8
52	R:R:F103	R:R:T107	13.8765	3.89	No	Yes	6	5	5
53	R:R:F103	R:R:L161	11.7121	7.31	No	No	0	5	4
54	R:R:H249	R:R:Y110	13.4741	15.24	Yes	Yes	0	8	7
55	R:R:R193	R:R:Y110	14.0627	11.32	Yes	Yes	7	5	7
56	R:R:A208	R:R:Y124	22.6121	2.67	No	Yes	0	6	7
57	R:R:A208	R:R:S120	23.4429	3.42	No	No	0	6	9
58	R:R:H129	R:R:Y124	10.1922	9.8	Yes	Yes	3	6	7
59	R:R:T141	R:R:V145	10.7659	1.59	No	No	0	4	5
60	R:R:M189	R:R:Y192	10.155	4.79	No	No	0	5	3
61	R:R:M189	R:R:R193	17.6129	7.44	No	Yes	0	5	5
62	R:R:R255	R:R:Y276	27.4922	9.26	No	Yes	0	4	5
63	R:R:R255	R:R:Y180	24.0054	7.2	No	Yes	0	4	4
64	R:R:V186	R:R:Y180	19.3861	3.79	No	Yes	0	4	4
65	R:R:E183	R:R:V186	18.1344	11.41	No	No	0	3	4
66	R:R:E183	R:R:P184	14.5023	3.14	No	No	0	3	3
67	R:R:F259	R:R:P184	13.2208	7.22	No	No	0	3	3
68	R:R:F259	R:R:M182	11.9319	9.95	No	No	0	3	2
69	R:R:L237	R:R:L293	10.7026	6.92	No	Yes	0	7	7
70	R:R:D71	R:R:L67	10.2481	5.43	Yes	No	5	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9J31_nogp

PDB Summary
PDB	9J31_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.79
Number of Linked Nodes	259
Number of Links	275
Number of Hubs	34
Number of Links mediated by Hubs	126
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	38

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	51443
Length Of Smallest Path	3
Average Path Length	15.9478
Length of Longest Path	33
Minimum Path Strength	1.495
Average Path Strength	6.86383
Maximum Path Strength	16.995
Minimum Path Correlation	0.7
Average Path Correlation	0.929777
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	42.5519
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.125
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • response to pH • response to abiotic stimulus • response to acidic pH • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	E7FEL0
Sequence	>9J31_nogp_Chain_R C N V D S N I D Q F F Q P T L Y I I V I V L G F P T N C M A L W A A Y M Q V K Q K N E L G I Y L M N L S I A D L L Y I T T L P L W I D Y F V H H V S C K L F G F I F Y T N I Y V S I A F L C C I S V D R Y L A V A H P L K F A K V R R V K T A L L V S A I V W L T E I V A N S A P L F H C F E K Y P M E P W V A G M N L Y R T F L G F L A P W G I M L A A Y R G I L R A V R G N V S T E R Q E K A K I K R L A L S L I L I V L L C F A P Y H V L L L W R S V L F L I N P C D C G G E E N L F G A Y H V T L A L T S L N C V A D P I L Y C F V N E G A R H D V G R A L A T L L G L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	10.1016/j.cell.2024.12.001
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZFJ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2024-08-07	To be published
	8ZFJ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.1	2024-08-07	To be published
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	10.1016/j.cell.2024.12.001

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9J31_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.