psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D81	R:R:S13	4.42	Yes	Yes	1	4	5
2	R:R:H165	R:R:S13	5.58	Yes	Yes	1	3	5
3	R:R:F272	R:R:S13	3.96	Yes	Yes	1	4	5
4	R:R:L15	R:R:L19	5.54	No	Yes	0	5	5
5	R:R:D16	R:R:P20	6.44	Yes	No	0	5	5
6	R:R:D16	R:R:Y77	8.05	Yes	Yes	1	5	5
7	R:R:D16	R:R:D81	3.99	Yes	Yes	1	5	4
8	R:R:D16	R:R:H276	12.61	Yes	Yes	1	5	5
9	R:R:L19	R:R:P20	4.93	Yes	No	0	5	5
10	R:R:P20	R:R:P21	5.84	No	No	0	5	6
11	R:R:L78	R:R:P21	9.85	No	No	0	5	6
12	R:R:A280	R:R:L23	4.73	No	No	0	4	4
13	R:R:L70	R:R:Y24	5.86	Yes	No	1	8	8
14	R:R:T74	R:R:Y24	6.24	No	No	0	7	8
15	R:R:T283	R:R:Y24	4.99	Yes	No	1	7	8
16	R:R:L26	R:R:L30	5.54	No	No	0	4	5
17	R:R:F28	R:R:I67	3.77	No	Yes	0	7	5
18	R:R:L32	R:R:L36	4.15	Yes	No	4	5	3
19	R:R:L32	R:R:L64	5.54	Yes	Yes	4	5	7
20	R:R:I67	R:R:L32	5.71	Yes	Yes	4	5	5
21	R:R:D63	R:R:N35	9.42	Yes	No	0	9	9
22	R:R:L64	R:R:N35	4.12	Yes	No	0	7	9
23	R:R:N35	R:R:P290	6.52	No	No	0	9	9
24	R:R:L36	R:R:L64	4.15	No	Yes	4	3	7
25	R:R:L37	R:R:V304	7.45	No	Yes	0	5	6
26	R:R:L39	R:R:L57	4.15	No	No	0	7	5
27	R:R:W40	R:R:W43	5.62	No	No	0	3	3
28	R:R:L44	R:R:W40	15.94	No	No	0	4	3
29	R:R:A41	R:R:V304	5.09	No	Yes	0	7	6
30	R:R:V46	R:R:W43	4.9	No	No	0	5	3
31	R:R:E303	R:R:L44	14.58	No	No	0	6	4
32	R:R:L52	R:R:Q45	3.99	Yes	No	0	7	5
33	R:R:G53	R:R:Q45	4.93	No	No	0	7	5
34	R:R:E51	R:R:Y55	4.49	Yes	Yes	3	6	7
35	R:R:D114	R:R:E51	14.29	Yes	Yes	3	8	6
36	R:R:E51	R:R:P126	6.29	Yes	Yes	3	6	5
37	R:R:E51	R:R:P130	4.72	Yes	Yes	3	6	5
38	R:R:L52	R:R:L56	4.15	Yes	No	0	7	8
39	R:R:L52	R:R:V111	4.47	Yes	No	0	7	8
40	R:R:D114	R:R:L52	4.07	Yes	Yes	0	8	7
41	R:R:V54	R:R:Y55	3.79	No	Yes	0	6	7
42	R:R:C110	R:R:Y55	6.72	No	Yes	0	6	7
43	R:R:D114	R:R:Y55	4.6	Yes	Yes	3	8	7
44	R:R:A134	R:R:Y55	5.34	No	Yes	0	8	7
45	R:R:V137	R:R:Y55	3.79	No	Yes	0	5	7
46	R:R:L57	R:R:N58	4.12	No	Yes	0	5	9
47	R:R:F107	R:R:N58	13.29	No	Yes	5	7	9
48	R:R:N58	R:R:S138	5.96	Yes	No	5	9	7
49	R:R:N58	R:R:W142	4.52	Yes	No	5	9	9
50	R:R:L108	R:R:L59	4.15	Yes	No	2	8	9
51	R:R:D289	R:R:L59	12.21	Yes	No	2	9	9
52	R:R:N100	R:R:S62	10.43	No	No	0	9	8
53	R:R:S62	R:R:V103	6.46	No	No	0	8	7
54	R:R:D63	R:R:N100	6.73	Yes	No	0	9	9
55	R:R:C286	R:R:D63	10.89	No	Yes	0	7	9
56	R:R:D289	R:R:D63	6.65	Yes	Yes	0	9	9
57	R:R:I67	R:R:L64	5.71	Yes	Yes	4	5	7
58	R:R:L65	R:R:V96	4.47	No	No	0	7	5
59	R:R:L66	R:R:L70	4.15	Yes	Yes	1	7	8
60	R:R:F97	R:R:L66	9.74	Yes	Yes	1	7	7
61	R:R:L66	R:R:N100	16.48	Yes	No	0	7	9
62	R:R:L66	R:R:T283	4.42	Yes	Yes	1	7	7
63	R:R:F97	R:R:L70	4.87	Yes	Yes	1	7	8
64	R:R:L70	R:R:T283	7.37	Yes	Yes	1	8	7
65	R:R:P71	R:R:P72	7.79	No	No	0	9	6
66	R:R:F93	R:R:P72	14.45	No	No	0	5	6
67	R:R:W73	R:R:Y76	6.75	Yes	Yes	1	6	6
68	R:R:W73	R:R:Y77	3.86	Yes	Yes	1	6	5
69	R:R:G94	R:R:W73	4.22	No	Yes	0	6	6
70	R:R:F97	R:R:W73	4.01	Yes	Yes	1	7	6
71	R:R:D75	R:R:R79	11.91	No	No	0	4	4
72	R:R:D75	R:R:Y85	16.09	No	No	0	4	6
73	R:R:Y76	R:R:Y77	12.91	Yes	Yes	1	6	5
74	R:R:W83	R:R:Y76	9.65	Yes	Yes	1	8	6
75	R:R:F167	R:R:Y76	5.16	Yes	Yes	1	3	6
76	R:R:H276	R:R:Y77	19.6	Yes	Yes	1	5	5
77	R:R:R79	R:R:V82	7.85	No	No	0	4	4
78	R:R:D81	R:R:H165	8.82	Yes	Yes	1	4	3
79	R:R:D81	R:R:F167	8.36	Yes	Yes	1	4	3
80	R:R:D81	R:R:F272	4.78	Yes	Yes	1	4	4
81	R:R:W83	R:R:Y85	13.5	Yes	No	0	8	6
82	R:R:C90	R:R:W83	13.06	No	Yes	1	9	8
83	R:R:F93	R:R:W83	5.01	No	Yes	0	5	8
84	R:R:C168	R:R:W83	3.92	No	Yes	1	9	8
85	R:R:G86	R:R:P87	4.06	No	No	0	8	3
86	R:R:I158	R:R:P87	6.77	Yes	No	0	4	3
87	R:R:C168	R:R:C90	7.28	No	No	1	9	9
88	R:R:L153	R:R:R91	4.86	No	No	0	4	7
89	R:R:G155	R:R:R91	4.5	No	No	0	3	7
90	R:R:G94	R:R:Y169	5.79	No	No	0	6	3
91	R:R:F95	R:R:T99	7.78	No	No	0	5	4
92	R:R:F95	R:R:L153	6.09	No	No	0	5	4
93	R:R:F97	R:R:Y98	11.35	Yes	No	0	7	5
94	R:R:F97	R:R:L279	7.31	Yes	No	0	7	6
95	R:R:F97	R:R:T283	3.89	Yes	Yes	1	7	7
96	R:R:Y241	R:R:Y98	3.97	Yes	No	0	7	5
97	R:R:N149	R:R:T99	8.77	No	No	0	6	4
98	R:R:L101	R:R:Y238	7.03	No	No	0	7	8
99	R:R:R186	R:R:Y102	23.66	Yes	No	0	6	7
100	R:R:H242	R:R:Y102	6.53	Yes	No	0	8	7
101	R:R:V103	R:R:W142	14.71	No	No	0	7	9
102	R:R:F107	R:R:S138	6.61	No	No	5	7	7
103	R:R:F107	R:R:W142	7.02	No	No	5	7	9
104	R:R:L108	R:R:M198	5.65	Yes	Yes	2	8	7
105	R:R:D289	R:R:L108	8.14	Yes	Yes	2	9	8
106	R:R:L108	R:R:Y293	7.03	Yes	No	2	8	9
107	R:R:R115	R:R:V111	6.54	No	No	0	9	8
108	R:R:M198	R:R:S112	6.13	Yes	No	2	7	9
109	R:R:C201	R:R:S112	5.16	No	No	0	7	9
110	R:R:S112	R:R:Y202	16.53	No	Yes	2	9	9
111	R:R:D114	R:R:F125	4.78	Yes	Yes	0	8	5
112	R:R:R115	R:R:Y202	8.23	No	Yes	0	9	9
113	R:R:A120	R:R:Y116	5.34	No	No	0	7	8
114	R:R:C201	R:R:Y116	5.38	No	No	0	7	8
115	R:R:F125	R:R:L117	15.83	Yes	No	0	5	6
116	R:R:L205	R:R:V119	7.45	No	No	0	8	8
117	R:R:F125	R:R:P126	11.56	Yes	Yes	0	5	5
118	R:R:P126	R:R:P130	7.79	Yes	Yes	3	5	5
119	R:R:A148	R:R:R186	4.15	No	Yes	0	4	6
120	R:R:N149	R:R:R186	4.82	No	Yes	0	6	6
121	R:R:P151	R:R:P152	5.84	No	No	0	8	4
122	R:R:E156	R:R:H159	7.39	No	No	0	6	1
123	R:R:A157	R:R:Y169	4	No	No	0	4	3
124	R:R:I158	R:R:R160	6.26	Yes	No	0	4	1
125	R:R:H159	R:R:S171	11.16	No	No	0	1	4
126	R:R:R160	R:R:T166	11.64	No	No	0	1	5
127	R:R:D161	R:R:H165	12.61	No	Yes	0	1	3
128	R:R:R162	R:R:Y163	8.23	No	No	0	2	2
129	R:R:F167	R:R:H165	10.18	Yes	Yes	1	3	3
130	R:R:F167	R:R:Y172	5.16	Yes	Yes	1	3	5
131	R:R:E170	R:R:Y172	6.73	No	Yes	1	6	5
132	R:R:E170	R:R:H276	9.85	No	Yes	1	6	5
133	R:R:R248	R:R:Y172	5.14	Yes	Yes	1	5	5
134	R:R:F272	R:R:Y172	6.19	Yes	Yes	1	4	5
135	R:R:Y172	R:R:Y275	5.96	Yes	Yes	1	5	6
136	R:R:H276	R:R:Y172	5.44	Yes	Yes	1	5	5
137	R:R:F252	R:R:L174	4.87	No	No	0	4	3
138	R:R:L253	R:R:R177	7.29	No	No	0	4	1
139	R:R:L181	R:R:L253	5.54	No	No	0	3	4
140	R:R:L245	R:R:N183	10.98	No	No	0	6	5
141	R:R:N183	R:R:S249	5.96	No	No	0	5	5
142	R:R:G190	R:R:R186	4.5	No	Yes	0	6	6
143	R:R:H242	R:R:V187	4.15	Yes	No	0	8	6
144	R:R:L245	R:R:V187	4.47	No	No	0	6	6
145	R:R:L246	R:R:V187	5.96	No	No	0	6	6
146	R:R:G190	R:R:P194	4.06	No	Yes	0	6	9
147	R:R:F191	R:R:W195	7.02	Yes	Yes	0	9	6
148	R:R:F191	R:R:Y238	4.13	Yes	No	0	9	8
149	R:R:F191	R:R:H242	12.44	Yes	Yes	0	9	8
150	R:R:L193	R:R:P194	4.93	No	Yes	0	5	9
151	R:R:L235	R:R:W195	13.67	No	Yes	0	5	6
152	R:R:M198	R:R:Y202	4.79	Yes	Yes	2	7	9
153	R:R:M198	R:R:P231	8.39	Yes	No	2	7	7
154	R:R:M199	R:R:P231	5.03	No	No	0	4	7
155	R:R:A227	R:R:Y202	4	No	Yes	0	7	9
156	R:R:L230	R:R:Y202	5.86	No	Yes	0	7	9
157	R:R:P231	R:R:Y202	9.74	No	Yes	2	7	9
158	R:R:G204	R:R:R207	4.5	No	No	0	4	4
159	R:R:L209	R:R:R220	4.86	No	No	0	8	6
160	R:R:R220	R:R:S212	3.95	No	No	0	6	5
161	R:R:C215	R:R:E219	4.56	No	No	0	2	5
162	R:R:C232	R:R:G229	3.92	No	No	0	4	5
163	R:R:L230	R:R:L292	4.15	No	No	0	7	7
164	R:R:L230	R:R:Y293	10.55	No	No	0	7	9
165	R:R:L292	R:R:V233	4.47	No	No	0	7	6
166	R:R:C237	R:R:N285	7.87	No	No	0	8	9
167	R:R:N285	R:R:Y238	9.3	No	No	0	9	8
168	R:R:G239	R:R:P240	4.06	No	No	0	6	9
169	R:R:H242	R:R:Y241	6.53	Yes	Yes	0	8	7
170	R:R:Y241	R:R:Y275	13.9	Yes	Yes	0	7	6
171	R:R:S278	R:R:Y241	5.09	No	Yes	0	7	7
172	R:R:L279	R:R:Y241	9.38	No	Yes	0	6	7
173	R:R:L271	R:R:R248	4.86	No	Yes	0	4	5
174	R:R:R248	R:R:Y275	8.23	Yes	Yes	1	5	6
175	R:R:G263	R:R:L267	5.13	No	Yes	0	2	1
176	R:R:F272	R:R:P273	4.33	Yes	No	0	4	3
177	R:R:F272	R:R:H276	13.58	Yes	Yes	1	4	5
178	R:R:H276	R:R:Y275	7.62	Yes	Yes	1	5	6
179	R:R:D289	R:R:N285	13.46	Yes	No	0	9	9
180	R:R:D289	R:R:Y293	4.6	Yes	No	2	9	9
181	R:R:L295	R:R:R301	9.72	No	No	0	8	8
182	R:R:C297	R:R:P298	3.77	No	No	0	7	6
183	R:R:E303	R:R:V304	4.28	No	Yes	0	6	6
184	R:R:A34	R:R:P290	3.74	No	No	0	7	9
185	R:R:K48	R:R:R50	3.71	No	No	0	5	7
186	R:R:L174	R:R:R248	3.64	No	Yes	0	3	5
187	R:R:A300	R:R:C294	3.61	No	No	0	8	6
188	R:R:P194	R:R:S109	3.56	Yes	No	0	9	7
189	R:R:E145	R:R:R186	3.49	No	Yes	0	7	6
190	R:R:C215	R:R:S212	3.44	No	No	0	2	5
191	R:R:G31	R:R:L287	3.42	No	No	0	8	6
192	R:R:A38	R:R:S60	3.42	No	No	0	9	9
193	R:R:C294	R:R:V304	3.42	No	Yes	0	6	6
194	R:R:A69	R:R:V96	3.39	No	No	0	6	5
195	R:R:L32	R:R:P33	3.28	Yes	No	0	5	4
196	R:R:L281	R:R:P240	3.28	No	No	0	7	9
197	R:R:C168	R:R:I158	3.27	No	Yes	0	9	4
198	R:R:S109	R:R:V197	3.23	No	No	0	7	6
199	R:R:S249	R:R:V184	3.23	No	No	0	5	4
200	R:R:A234	R:R:M198	3.22	No	Yes	0	9	7
201	R:R:V46	R:R:V54	3.21	No	No	0	5	6
202	R:R:C232	R:R:L228	3.17	No	No	0	4	4
203	R:R:C294	R:R:L295	3.17	No	No	0	6	8
204	R:R:A180	R:R:L253	3.15	No	No	0	3	4
205	R:R:I67	R:R:V27	3.07	Yes	No	0	5	7
206	R:R:I141	R:R:V137	3.07	No	No	0	6	5
207	R:R:F252	R:R:G176	3.01	No	No	0	4	1
208	R:R:F191	R:R:G239	3.01	Yes	No	0	9	6
209	R:R:L244	R:R:S278	3	No	No	0	5	7
210	R:R:L37	R:R:V307	2.98	No	No	0	5	3
211	R:R:L267	R:R:V251	2.98	Yes	No	0	1	4
212	R:R:A120	R:R:H121	2.93	No	No	0	7	6
213	R:R:G204	R:R:Y116	2.9	No	No	0	4	8
214	R:R:G196	R:R:W195	2.81	No	Yes	0	2	6
215	R:R:P152	R:R:Y169	2.78	No	No	0	4	3
216	R:R:L19	R:R:L23	2.77	Yes	No	0	5	4
217	R:R:L26	R:R:L287	2.77	No	No	0	4	6
218	R:R:L61	R:R:L65	2.77	No	No	0	6	7
219	R:R:A180	R:R:F252	2.77	No	No	0	3	4
220	R:R:E216	R:R:E219	2.54	No	No	0	5	5
221	R:R:I131	R:R:R132	2.51	No	No	0	3	4
222	R:R:F95	R:R:L146	2.44	No	No	0	5	3
223	R:R:L206	R:R:R224	2.43	No	No	0	5	5
224	R:R:Q45	R:R:R50	2.34	No	No	0	5	7
225	R:R:L192	R:R:W195	2.28	No	Yes	0	4	6
226	R:R:H165	R:R:Y163	2.18	Yes	No	0	3	2
227	R:R:R210	R:R:R220	2.13	No	No	0	5	6
228	R:R:G263	R:R:G264	2.11	No	No	0	2	3
229	R:R:G127	R:R:P126	2.03	No	Yes	0	4	5
230	R:R:G299	R:R:P298	2.03	No	No	0	6	6
231	R:R:A34	R:R:G31	1.95	No	No	0	7	8
232	R:R:A38	R:R:P290	1.87	No	No	0	9	9
233	R:R:A105	R:R:P194	1.87	No	Yes	0	8	9
234	R:R:A150	R:R:P151	1.87	No	No	0	3	8
235	R:R:G14	R:R:S13	1.86	No	Yes	0	2	5
236	R:R:G14	R:R:S17	1.86	No	No	0	2	4
237	R:R:G104	R:R:S62	1.86	No	No	0	9	8
238	R:R:A113	R:R:C201	1.81	No	No	0	5	7
239	R:R:A120	R:R:A208	1.79	No	No	0	7	5
240	R:R:C215	R:R:S214	1.72	No	No	0	2	3
241	R:R:G155	R:R:L154	1.71	No	No	0	3	4
242	R:R:A208	R:R:V119	1.7	No	No	0	5	8
243	R:R:A288	R:R:V233	1.7	No	No	0	6	6
244	R:R:I131	R:R:P130	1.69	No	Yes	0	3	5
245	R:R:S17	R:R:V18	1.62	No	No	0	4	4
246	R:R:A106	R:R:I141	1.62	No	No	0	6	6
247	R:R:C68	R:R:L64	1.59	No	Yes	0	4	7
248	R:R:A277	R:R:L19	1.58	No	Yes	0	5	5
249	R:R:A42	R:R:L56	1.58	No	No	0	6	8
250	R:R:A42	R:R:L57	1.58	No	No	0	6	5
251	R:R:A282	R:R:L101	1.58	No	No	0	8	7
252	R:R:A227	R:R:L206	1.58	No	No	0	7	5
253	R:R:A274	R:R:L244	1.58	No	No	0	4	5
254	R:R:A274	R:R:L271	1.58	No	No	0	4	4
255	R:R:A291	R:R:L292	1.58	No	No	0	6	7
256	R:R:H121	R:R:P122	1.53	No	No	0	6	8
257	R:R:L284	R:R:V27	1.49	No	No	0	5	7
258	R:R:L188	R:R:V184	1.49	No	No	0	4	4
259	R:R:L205	R:R:V223	1.49	No	No	0	8	7
260	R:R:L209	R:R:V223	1.49	No	No	0	8	7
261	R:R:L247	R:R:V251	1.49	No	No	0	5	4
262	R:R:P130	R:R:R129	1.44	Yes	No	0	5	7
263	R:R:L228	R:R:M199	1.41	No	No	0	4	4
264	R:R:A89	R:R:F93	1.39	No	No	0	5	5
265	R:R:A118	R:R:F125	1.39	No	Yes	0	8	5
266	R:R:L246	R:R:L250	1.38	No	No	0	6	4
267	R:R:L247	R:R:L271	1.38	No	No	0	5	4
268	R:R:A266	R:R:R270	1.38	No	No	0	4	3
269	R:R:A305	R:R:R301	1.38	No	No	0	5	8
270	R:R:E156	R:R:I158	1.37	No	Yes	0	6	4
271	R:R:E268	R:R:L267	1.33	No	Yes	0	4	1
272	R:R:R80	R:R:S17	1.32	No	No	0	3	4
273	R:R:R222	R:R:V223	1.31	No	No	0	8	7
274	R:R:E216	R:R:Q217	1.27	No	No	0	5	3
275	R:R:K48	R:R:R47	1.24	No	No	0	5	6
276	R:R:L267	R:R:R270	1.21	Yes	No	0	1	3
277	R:R:Q217	R:R:R221	1.17	No	No	0	3	5
278	R:R:H121	R:R:R124	1.13	No	No	0	6	4
279	R:R:R224	R:R:R225	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S13	3.955	4	1	5
2	R:R:D16	7.7725	4	1	5
3	R:R:L19	3.705	4	0	5
4	R:R:L32	4.67	4	4	5
5	R:R:E51	7.4475	4	3	6
6	R:R:L52	4.17	4	0	7
7	R:R:Y55	4.78833	6	3	7
8	R:R:N58	6.9725	4	5	9
9	R:R:D63	8.4225	4	0	9
10	R:R:L64	4.222	5	4	7
11	R:R:L66	8.6975	4	1	7
12	R:R:I67	4.565	4	4	5
13	R:R:L70	5.5625	4	1	8
14	R:R:W73	4.71	4	1	6
15	R:R:Y76	8.6175	4	1	6
16	R:R:Y77	11.105	4	1	5
17	R:R:D81	6.074	5	1	4
18	R:R:W83	9.028	5	1	8
19	R:R:F97	6.86167	6	1	7
20	R:R:L108	6.2425	4	2	8
21	R:R:D114	6.935	4	3	8
22	R:R:F125	8.39	4	0	5
23	R:R:P126	6.9175	4	3	5
24	R:R:P130	3.91	4	3	5
25	R:R:I158	4.4175	4	0	4
26	R:R:H165	7.874	5	1	3
27	R:R:F167	7.215	4	1	3
28	R:R:Y172	5.77	6	1	5
29	R:R:R186	8.124	5	0	6
30	R:R:F191	6.65	4	0	9
31	R:R:P194	3.605	4	0	9
32	R:R:W195	6.445	4	0	6
33	R:R:M198	5.636	5	2	7
34	R:R:Y202	8.19167	6	2	9
35	R:R:Y241	7.774	5	0	7
36	R:R:H242	7.4125	4	0	8
37	R:R:R248	5.4675	4	1	5
38	R:R:L267	2.6625	4	0	1
39	R:R:F272	6.568	5	1	4
40	R:R:Y275	8.9275	4	1	6
41	R:R:H276	11.45	6	1	5
42	R:R:T283	5.1675	4	1	7
43	R:R:D289	9.012	5	2	9
44	R:R:V304	5.06	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D16	R:R:P20	15.0504	6.44	Yes	No	0	5	5
2	R:R:D16	R:R:Y77	19.3242	8.05	Yes	Yes	1	5	5
3	R:R:W73	R:R:Y77	31.7171	3.86	Yes	Yes	1	6	5
4	R:R:F97	R:R:W73	92.2443	4.01	Yes	Yes	1	7	6
5	R:R:F167	R:R:Y76	29.2602	5.16	Yes	Yes	1	3	6
6	R:R:W73	R:R:Y76	53.6935	6.75	Yes	Yes	1	6	6
7	R:R:F97	R:R:L66	92.9385	9.74	Yes	Yes	1	7	7
8	R:R:L66	R:R:N100	100	16.48	Yes	No	0	7	9
9	R:R:D63	R:R:N100	75.3932	6.73	Yes	No	0	9	9
10	R:R:D63	R:R:N35	31.0392	9.42	Yes	No	0	9	9
11	R:R:N35	R:R:P290	14.2261	6.52	No	No	0	9	9
12	R:R:L64	R:R:N35	15.9562	4.12	Yes	No	0	7	9
13	R:R:N100	R:R:S62	32.1944	10.43	No	No	0	9	8
14	R:R:S62	R:R:V103	29.8297	6.46	No	No	0	8	7
15	R:R:V103	R:R:W142	28.6474	14.71	No	No	0	7	9
16	R:R:N58	R:R:W142	24.8454	4.52	Yes	No	5	9	9
17	R:R:L57	R:R:N58	23.7553	4.12	No	Yes	0	5	9
18	R:R:A42	R:R:L57	22.2692	1.58	No	No	0	6	5
19	R:R:A42	R:R:L56	21.6835	1.58	No	No	0	6	8
20	R:R:L52	R:R:L56	21.9655	4.15	Yes	No	0	7	8
21	R:R:D114	R:R:L52	92.1033	4.07	Yes	Yes	0	8	7
22	R:R:D114	R:R:Y55	57.311	4.6	Yes	Yes	3	8	7
23	R:R:V54	R:R:Y55	42.2985	3.79	No	Yes	0	6	7
24	R:R:V46	R:R:V54	39.5542	3.21	No	No	0	5	6
25	R:R:V46	R:R:W43	36.799	4.9	No	No	0	5	3
26	R:R:W40	R:R:W43	34.033	5.62	No	No	0	3	3
27	R:R:L44	R:R:W40	31.2561	15.94	No	No	0	4	3
28	R:R:E303	R:R:L44	28.4684	14.58	No	No	0	6	4
29	R:R:E303	R:R:V304	25.6698	4.28	No	Yes	0	6	6
30	R:R:D289	R:R:D63	79.5151	6.65	Yes	Yes	0	9	9
31	R:R:D289	R:R:L108	79.1029	8.14	Yes	Yes	2	9	8
32	R:R:L108	R:R:M198	79.1246	5.65	Yes	Yes	2	8	7
33	R:R:M198	R:R:Y202	47.2394	4.79	Yes	Yes	2	7	9
34	R:R:R115	R:R:Y202	93.8117	8.23	No	Yes	0	9	9
35	R:R:R115	R:R:V111	92.0111	6.54	No	No	0	9	8
36	R:R:L52	R:R:V111	90.1562	4.47	Yes	No	0	7	8
37	R:R:D289	R:R:Y293	52.0176	4.6	Yes	No	2	9	9
38	R:R:L230	R:R:Y293	51.4427	10.55	No	No	0	7	9
39	R:R:L230	R:R:Y202	48.5356	5.86	No	Yes	0	7	9
40	R:R:L52	R:R:Q45	14.4213	3.99	Yes	No	0	7	5
41	R:R:D114	R:R:E51	19.129	14.29	Yes	Yes	3	8	6
42	R:R:D114	R:R:F125	13.7867	4.78	Yes	Yes	0	8	5
43	R:R:E51	R:R:P130	11.4058	4.72	Yes	Yes	3	6	5
44	R:R:W83	R:R:Y76	46.0571	9.65	Yes	Yes	1	8	6
45	R:R:G94	R:R:W73	13.3474	4.22	No	Yes	0	6	6
46	R:R:W83	R:R:Y85	10.0607	13.5	Yes	No	0	8	6
47	R:R:C168	R:R:W83	22.3072	3.92	No	Yes	1	9	8
48	R:R:C168	R:R:I158	19.91	3.27	No	Yes	0	9	4
49	R:R:H276	R:R:Y275	17.9737	7.62	Yes	Yes	1	5	6
50	R:R:Y241	R:R:Y275	56.2751	13.9	Yes	Yes	0	7	6
51	R:R:H242	R:R:Y241	68.0985	6.53	Yes	Yes	0	8	7
52	R:R:H242	R:R:Y102	36.3434	6.53	Yes	No	0	8	7
53	R:R:R186	R:R:Y102	34.3909	23.66	Yes	No	0	6	7
54	R:R:N149	R:R:R186	16.4768	4.82	No	Yes	0	6	6
55	R:R:N149	R:R:T99	14.6111	8.77	No	No	0	6	4
56	R:R:F95	R:R:T99	12.5556	7.78	No	No	0	5	4
57	R:R:F272	R:R:H276	15.7826	13.58	Yes	Yes	1	4	5
58	R:R:F167	R:R:Y172	10.077	5.16	Yes	Yes	1	3	5
59	R:R:Y172	R:R:Y275	15.3108	5.96	Yes	Yes	1	5	6
60	R:R:G94	R:R:Y169	11.2539	5.79	No	No	0	6	3
61	R:R:F97	R:R:Y98	15.9399	11.35	Yes	No	0	7	5
62	R:R:Y241	R:R:Y98	15.0016	3.97	Yes	No	0	7	5
63	R:R:F97	R:R:L279	15.8857	7.31	Yes	No	0	7	6
64	R:R:L279	R:R:Y241	15.0342	9.38	No	Yes	0	6	7
65	R:R:F191	R:R:H242	64.4376	12.44	Yes	Yes	0	9	8
66	R:R:F191	R:R:Y238	63.483	4.13	Yes	No	0	9	8
67	R:R:M198	R:R:S112	26.2881	6.13	Yes	No	2	7	9
68	R:R:C201	R:R:S112	33.7672	5.16	No	No	0	7	9
69	R:R:A120	R:R:Y116	27.2047	5.34	No	No	0	7	8
70	R:R:C201	R:R:Y116	31.1747	5.38	No	No	0	7	8
71	R:R:A120	R:R:A208	21.754	1.79	No	No	0	7	5
72	R:R:A208	R:R:V119	20.4578	1.7	No	No	0	5	8
73	R:R:L205	R:R:V119	19.0585	7.45	No	No	0	8	8
74	R:R:L174	R:R:R248	13.2498	3.64	No	Yes	0	3	5
75	R:R:F252	R:R:L174	11.5143	4.87	No	No	0	4	3
76	R:R:H242	R:R:V187	16.6558	4.15	Yes	No	0	8	6
77	R:R:L245	R:R:V187	10.4892	4.47	No	No	0	6	6
78	R:R:G190	R:R:R186	12.5556	4.5	No	Yes	0	6	6
79	R:R:G190	R:R:P194	10.4892	4.06	No	Yes	0	6	9
80	R:R:L205	R:R:V223	17.6483	1.49	No	No	0	8	7
81	R:R:L209	R:R:V223	14.8986	1.49	No	No	0	8	7
82	R:R:L209	R:R:R220	13.4505	4.86	No	No	0	8	6
83	R:R:R220	R:R:S212	10.538	3.95	No	No	0	6	5
84	R:R:N285	R:R:Y238	63.0925	9.3	No	No	0	9	8
85	R:R:L271	R:R:R248	17.6049	4.86	No	Yes	0	4	5
86	R:R:L247	R:R:L271	15.2565	1.38	No	No	0	5	4
87	R:R:L247	R:R:V251	13.3962	1.49	No	No	0	5	4
88	R:R:L267	R:R:V251	11.5143	2.98	Yes	No	0	1	4
89	R:R:C294	R:R:V304	14.3671	3.42	No	Yes	0	6	6
90	R:R:D81	R:R:S13	12.9569	4.42	Yes	Yes	1	4	5
91	R:R:G14	R:R:S13	29.0216	1.86	No	Yes	0	2	5
92	R:R:G14	R:R:S17	21.7811	1.86	No	No	0	2	4
93	R:R:F167	R:R:H165	13.4451	10.18	Yes	Yes	1	3	3
94	R:R:H276	R:R:Y77	17.6266	19.6	Yes	Yes	1	5	5
95	R:R:F272	R:R:S13	16.4009	3.96	Yes	Yes	1	4	5
96	R:R:D289	R:R:N285	64.264	13.46	Yes	No	0	9	9
97	R:R:R248	R:R:Y275	25.6102	8.23	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ZF4

PDB Summary
PDB	8ZF4
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR4
Species	Xenopus tropicalis
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.05
Date	2025-02-26
D.O.I.	10.1016/j.cell.2024.12.001

Net Summary
I_min	3.77
Number of Linked Nodes	248
Number of Links	279
Number of Hubs	44
Number of Links mediated by Hubs	144
Number of Communities	5
Number of Nodes involved in Communities	43
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	50676
Length Of Smallest Path	3
Average Path Length	14.9994
Length of Longest Path	33
Minimum Path Strength	1.22
Average Path Strength	6.88009
Maximum Path Strength	16.255
Minimum Path Correlation	0.7
Average Path Correlation	0.933774
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.9899
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.4729
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	A0A6I8PUB9
Sequence	>8ZF4_Chain_R S G L D S V L P P S L Y A L V F T L G L P A N L L A L W A A W L Q V R K G R E L G V Y L L N L S L S D L L L I C A L P P W T D Y Y L R R D V W G Y G P G A C R L F G F V F Y T N L Y V G A A F L S C V S A D R Y L A V A H P L R F P G A R P I R S A A A V S A L I W M L E L A A N A P P L L G E A I H R D R Y N H T F C Y E S Y P L S G R G A A L A N V G R V L A G F L L P W G V M M L C Y A G L L R A L R G S A S C E Q R E R R R V R R L A L G L P C V A L L C Y G P Y H A L L L L R S L V F L V G G C A L E E R L F P A Y H A S L A L A T L N C L A D P A L Y C L A C P G A R G E V A K V V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	10.1016/j.cell.2024.12.001
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZFJ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2024-08-07	To be published
	8ZFJ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.1	2024-08-07	To be published
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	10.1016/j.cell.2024.12.001

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZF4.zip

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