psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C258	R:R:C9	7.28	No	No	0	8	8
2	R:R:H10	R:R:Y163	29.4	No	No	0	3	3
3	R:R:H165	R:R:V11	2.77	No	No	0	1	3
4	R:R:F265	R:R:V11	13.11	Yes	No	0	4	3
5	R:R:D16	R:R:S13	11.78	Yes	No	0	5	5
6	R:R:F265	R:R:S13	5.28	Yes	No	0	4	5
7	R:R:S13	R:R:S266	4.89	No	No	0	5	2
8	R:R:R14	R:R:S266	7.91	No	No	0	2	2
9	R:R:D16	R:R:D81	3.99	Yes	Yes	1	5	4
10	R:R:D16	R:R:H269	6.3	Yes	Yes	1	5	5
11	R:R:H17	R:R:L18	16.71	No	No	0	5	4
12	R:R:H17	R:R:H80	5.97	No	No	0	5	4
13	R:R:F19	R:R:P20	2.89	Yes	Yes	0	5	5
14	R:R:F19	R:R:L23	7.31	Yes	No	0	5	5
15	R:R:F19	R:R:S270	5.28	Yes	No	0	5	5
16	R:R:P20	R:R:P21	5.84	Yes	No	0	5	7
17	R:R:P20	R:R:Y24	2.78	Yes	Yes	1	5	9
18	R:R:F77	R:R:P20	5.78	Yes	Yes	1	5	5
19	R:R:A273	R:R:P20	3.74	No	Yes	1	5	5
20	R:R:L23	R:R:V27	2.98	No	No	0	5	7
21	R:R:L70	R:R:Y24	5.86	No	Yes	0	8	9
22	R:R:V74	R:R:Y24	3.79	No	Yes	0	7	9
23	R:R:F77	R:R:Y24	6.19	Yes	Yes	1	5	9
24	R:R:A273	R:R:Y24	4	No	Yes	1	5	9
25	R:R:S276	R:R:Y24	5.09	No	Yes	0	7	9
26	R:R:F26	R:R:V30	3.93	No	No	0	4	6
27	R:R:S276	R:R:V27	6.46	No	No	0	7	7
28	R:R:V27	R:R:V280	3.21	No	Yes	0	7	8
29	R:R:G29	R:R:I28	3.53	No	No	0	5	7
30	R:R:I28	R:R:L70	5.71	No	No	0	7	8
31	R:R:V280	R:R:V30	3.21	Yes	No	0	8	6
32	R:R:I67	R:R:L32	2.85	No	No	0	6	6
33	R:R:P283	R:R:T34	6.99	No	No	0	9	7
34	R:R:D63	R:R:N35	6.73	No	Yes	0	9	9
35	R:R:L64	R:R:N35	2.75	No	Yes	0	8	9
36	R:R:I67	R:R:N35	2.83	No	Yes	0	6	9
37	R:R:N35	R:R:P283	8.15	Yes	No	0	9	9
38	R:R:L39	R:R:M57	2.83	No	Yes	0	7	5
39	R:R:L39	R:R:S60	4.5	No	No	0	7	8
40	R:R:W40	R:R:Y43	2.89	No	No	0	4	4
41	R:R:A42	R:R:L56	3.15	No	No	0	7	8
42	R:R:A42	R:R:M57	3.22	No	Yes	0	7	5
43	R:R:Q47	R:R:R44	12.85	No	No	0	6	4
44	R:R:Q48	R:R:R44	5.84	No	No	0	7	4
45	R:R:Q45	R:R:Q48	6.4	No	No	0	5	7
46	R:R:M57	R:R:V46	3.04	Yes	No	0	5	6
47	R:R:L52	R:R:N50	4.12	No	No	0	8	7
48	R:R:D114	R:R:E51	11.69	No	No	0	8	7
49	R:R:E51	R:R:R129	6.98	No	No	0	7	7
50	R:R:I111	R:R:L52	2.85	No	No	0	9	8
51	R:R:D114	R:R:L52	5.43	No	No	0	8	8
52	R:R:G53	R:R:L56	5.13	No	No	0	7	8
53	R:R:A134	R:R:V54	5.09	No	No	0	8	7
54	R:R:C110	R:R:Y55	4.03	No	Yes	0	7	7
55	R:R:I111	R:R:Y55	3.63	No	Yes	0	9	7
56	R:R:D114	R:R:Y55	4.6	No	Yes	0	8	7
57	R:R:A134	R:R:Y55	4	No	Yes	0	8	7
58	R:R:F107	R:R:N58	15.71	Yes	No	3	8	9
59	R:R:N58	R:R:S138	7.45	No	No	3	9	7
60	R:R:N58	R:R:W142	5.65	No	No	3	9	9
61	R:R:L108	R:R:L59	4.15	No	No	4	8	9
62	R:R:D282	R:R:L59	2.71	Yes	No	4	9	9
63	R:R:C279	R:R:D63	6.22	No	No	0	9	9
64	R:R:D282	R:R:D63	5.32	Yes	No	0	9	9
65	R:R:L65	R:R:N100	2.75	No	No	0	7	8
66	R:R:L70	R:R:Y66	5.86	No	Yes	0	8	7
67	R:R:F97	R:R:Y66	8.25	No	Yes	0	7	7
68	R:R:N100	R:R:Y66	5.81	No	Yes	0	8	7
69	R:R:C279	R:R:Y66	5.38	No	Yes	0	9	7
70	R:R:C279	R:R:I67	6.55	No	No	0	9	6
71	R:R:I96	R:R:T69	3.04	No	No	0	5	7
72	R:R:L72	R:R:W83	3.42	No	Yes	1	7	9
73	R:R:H85	R:R:L72	6.43	Yes	No	1	7	7
74	R:R:F93	R:R:L72	9.74	No	No	0	6	7
75	R:R:W73	R:R:Y76	8.68	Yes	Yes	1	7	6
76	R:R:F77	R:R:W73	3.01	Yes	Yes	1	5	7
77	R:R:W73	R:R:W83	2.81	Yes	Yes	1	7	9
78	R:R:F97	R:R:W73	15.03	No	Yes	0	7	7
79	R:R:D75	R:R:H79	8.82	No	No	0	4	4
80	R:R:D75	R:R:H85	3.78	No	Yes	0	4	7
81	R:R:F77	R:R:Y76	9.28	Yes	Yes	1	5	6
82	R:R:D81	R:R:Y76	10.34	Yes	Yes	1	4	6
83	R:R:W83	R:R:Y76	5.79	Yes	Yes	1	9	6
84	R:R:E170	R:R:Y76	4.49	Yes	Yes	1	4	6
85	R:R:F77	R:R:H269	3.39	Yes	Yes	1	5	5
86	R:R:D81	R:R:F265	3.58	Yes	Yes	1	4	4
87	R:R:D81	R:R:H269	6.3	Yes	Yes	1	4	5
88	R:R:N82	R:R:T166	4.39	No	No	0	5	3
89	R:R:H85	R:R:W83	3.17	Yes	Yes	1	7	9
90	R:R:G86	R:R:W83	2.81	No	Yes	0	8	9
91	R:R:S89	R:R:W83	7.41	No	Yes	1	6	9
92	R:R:C90	R:R:W83	7.84	No	Yes	1	9	9
93	R:R:C168	R:R:W83	7.84	No	Yes	1	9	9
94	R:R:H85	R:R:I84	9.28	Yes	No	0	7	3
95	R:R:H85	R:R:S89	2.79	Yes	No	1	7	6
96	R:R:G86	R:R:P87	4.06	No	No	0	8	3
97	R:R:L158	R:R:P87	3.28	No	No	0	5	3
98	R:R:C168	R:R:C90	7.28	No	No	1	9	9
99	R:R:K91	R:R:L153	4.23	No	No	0	6	4
100	R:R:F93	R:R:L92	4.87	No	No	0	6	5
101	R:R:F169	R:R:G94	6.02	Yes	No	0	4	6
102	R:R:F95	R:R:T99	7.78	No	No	0	6	5
103	R:R:F95	R:R:L153	13.4	No	No	0	6	4
104	R:R:I96	R:R:N100	2.83	No	No	0	5	8
105	R:R:F169	R:R:Y98	5.16	Yes	No	0	4	5
106	R:R:R185	R:R:Y98	4.12	No	No	0	5	5
107	R:R:N149	R:R:T99	5.85	No	No	0	7	5
108	R:R:F237	R:R:I101	6.28	Yes	No	0	8	8
109	R:R:R185	R:R:Y102	8.23	No	No	0	5	7
110	R:R:G189	R:R:Y102	2.9	No	No	0	6	7
111	R:R:H241	R:R:Y102	3.27	No	No	0	8	7
112	R:R:I103	R:R:W142	7.05	No	No	0	7	9
113	R:R:E145	R:R:I103	4.1	No	No	0	7	7
114	R:R:I105	R:R:S104	3.1	No	No	0	8	9
115	R:R:I105	R:R:P193	3.39	No	No	0	8	9
116	R:R:F237	R:R:I105	6.28	Yes	No	0	8	8
117	R:R:F107	R:R:S138	3.96	Yes	No	3	8	7
118	R:R:F107	R:R:V141	3.93	Yes	No	0	8	7
119	R:R:F107	R:R:W142	7.02	Yes	No	3	8	9
120	R:R:D282	R:R:L108	2.71	Yes	No	4	9	8
121	R:R:L108	R:R:Y286	4.69	No	No	0	8	9
122	R:R:C109	R:R:P193	3.77	No	No	0	8	9
123	R:R:C109	R:R:L196	4.76	No	No	0	8	6
124	R:R:I111	R:R:R115	3.76	No	No	0	9	9
125	R:R:M197	R:R:S112	4.6	No	No	0	7	9
126	R:R:S112	R:R:S200	6.52	No	No	0	9	8
127	R:R:S112	R:R:Y201	7.63	No	Yes	0	9	8
128	R:R:R115	R:R:Y201	7.2	No	Yes	0	9	8
129	R:R:A120	R:R:Y116	6.67	No	Yes	2	7	8
130	R:R:H121	R:R:Y116	4.36	Yes	Yes	2	6	8
131	R:R:G203	R:R:Y116	2.9	No	Yes	0	4	8
132	R:R:I204	R:R:V119	4.61	No	No	0	8	8
133	R:R:A120	R:R:H121	2.93	No	Yes	2	7	6
134	R:R:H121	R:R:R124	3.39	Yes	No	2	6	4
135	R:R:F125	R:R:H121	6.79	Yes	Yes	2	6	6
136	R:R:L123	R:R:P122	3.28	No	No	0	6	7
137	R:R:F125	R:R:R124	5.34	Yes	No	2	6	4
138	R:R:L128	R:R:R127	4.86	No	No	0	3	4
139	R:R:R130	R:R:T133	3.88	No	No	0	6	3
140	R:R:E145	R:R:N149	5.26	No	No	0	7	7
141	R:R:G147	R:R:S150	3.71	No	No	0	4	4
142	R:R:A151	R:R:M181	3.22	No	No	0	7	4
143	R:R:F169	R:R:P152	5.78	Yes	No	0	4	3
144	R:R:M181	R:R:P152	6.71	No	No	0	4	3
145	R:R:H155	R:R:W177	11.64	No	No	0	4	1
146	R:R:E157	R:R:F169	24.49	No	Yes	0	5	4
147	R:R:F159	R:R:K171	16.13	No	No	0	2	3
148	R:R:R160	R:R:T166	12.94	No	No	0	1	3
149	R:R:F167	R:R:H165	12.44	Yes	No	0	4	1
150	R:R:E170	R:R:F167	5.83	Yes	Yes	1	4	4
151	R:R:F167	R:R:F172	4.29	Yes	Yes	1	4	5
152	R:R:C168	R:R:F169	2.79	No	Yes	0	9	4
153	R:R:E170	R:R:F172	4.66	Yes	Yes	1	4	5
154	R:R:E170	R:R:H269	7.39	Yes	Yes	1	4	5
155	R:R:F172	R:R:R247	3.21	Yes	No	1	5	4
156	R:R:E261	R:R:F172	4.66	No	Yes	1	4	5
157	R:R:F172	R:R:F265	7.5	Yes	Yes	1	5	4
158	R:R:M174	R:R:V178	7.61	Yes	No	1	1	2
159	R:R:M174	R:R:N182	2.8	Yes	Yes	1	1	5
160	R:R:M174	R:R:S248	3.07	Yes	No	1	1	5
161	R:R:M174	R:R:Y251	7.18	Yes	Yes	0	1	3
162	R:R:E175	R:R:W177	9.81	No	No	0	2	1
163	R:R:G176	R:R:Y251	4.35	No	Yes	0	4	3
164	R:R:V178	R:R:W177	11.03	No	No	0	2	1
165	R:R:N182	R:R:V178	4.43	Yes	No	1	5	2
166	R:R:A179	R:R:L252	3.15	No	No	0	1	1
167	R:R:M181	R:R:R185	6.2	No	No	0	4	5
168	R:R:L244	R:R:N182	13.73	Yes	Yes	1	5	5
169	R:R:N182	R:R:S248	5.96	Yes	No	1	5	5
170	R:R:L183	R:R:S248	3	No	No	0	4	5
171	R:R:V188	R:R:Y184	10.09	No	No	0	4	3
172	R:R:L244	R:R:V186	2.98	Yes	No	0	5	5
173	R:R:F190	R:R:L191	4.87	No	No	0	8	4
174	R:R:F190	R:R:F237	5.36	No	Yes	0	8	8
175	R:R:F190	R:R:H241	9.05	No	No	0	8	8
176	R:R:F192	R:R:P193	2.89	No	No	0	5	9
177	R:R:F192	R:R:L196	4.87	No	No	0	5	6
178	R:R:I230	R:R:W194	4.7	No	No	0	7	6
179	R:R:V233	R:R:W194	3.68	No	No	0	9	6
180	R:R:L234	R:R:W194	13.67	No	No	0	6	6
181	R:R:I230	R:R:M197	2.92	No	No	0	7	7
182	R:R:A226	R:R:Y201	4	No	Yes	0	7	8
183	R:R:L229	R:R:Y201	4.69	Yes	Yes	0	8	8
184	R:R:R202	R:R:R206	4.26	No	No	0	3	3
185	R:R:G203	R:R:R206	3	No	No	0	4	3
186	R:R:R206	R:R:R209	5.33	No	No	0	3	4
187	R:R:S211	R:R:T214	6.4	No	No	0	5	3
188	R:R:E218	R:R:T214	5.64	No	No	0	5	3
189	R:R:K219	R:R:T214	4.5	No	No	0	6	3
190	R:R:K221	R:R:R224	3.71	No	No	0	7	6
191	R:R:L229	R:R:S228	3	Yes	No	0	8	6
192	R:R:L229	R:R:L285	4.15	Yes	No	0	8	8
193	R:R:L229	R:R:Y286	5.86	Yes	No	0	8	9
194	R:R:A281	R:R:I232	3.25	No	No	0	7	7
195	R:R:I232	R:R:L285	4.28	No	No	0	7	8
196	R:R:C236	R:R:N278	3.15	No	No	0	8	9
197	R:R:F237	R:R:T275	3.89	Yes	No	0	8	8
198	R:R:F237	R:R:N278	7.25	Yes	No	0	8	9
199	R:R:L244	R:R:Y240	5.86	Yes	Yes	1	5	6
200	R:R:Y240	R:R:Y268	7.94	Yes	No	1	6	5
201	R:R:S271	R:R:Y240	5.09	No	Yes	0	7	6
202	R:R:L272	R:R:Y240	4.69	No	Yes	0	5	6
203	R:R:T275	R:R:Y240	3.75	No	Yes	0	8	6
204	R:R:L243	R:R:S271	3	No	No	0	4	7
205	R:R:L244	R:R:Y268	3.52	Yes	No	1	5	5
206	R:R:E261	R:R:R247	13.96	No	No	1	4	4
207	R:R:R247	R:R:Y268	12.35	No	No	1	4	5
208	R:R:F260	R:R:I250	15.07	No	No	0	1	1
209	R:R:P255	R:R:Y251	2.78	No	Yes	0	2	3
210	R:R:D257	R:R:R254	7.15	No	No	0	5	2
211	R:R:C258	R:R:E261	3.04	No	No	0	8	4
212	R:R:F260	R:R:V264	10.49	No	No	0	1	4
213	R:R:F265	R:R:H269	12.44	Yes	Yes	1	4	5
214	R:R:F274	R:R:L277	3.65	No	No	0	7	5
215	R:R:D282	R:R:N278	9.42	Yes	No	0	9	9
216	R:R:C287	R:R:L288	3.17	Yes	No	0	7	7
217	R:R:G292	R:R:N290	3.39	No	No	0	6	8
218	R:R:A293	R:R:N290	4.69	No	No	0	8	8
219	R:R:E291	R:R:R294	17.45	No	No	0	5	8
220	R:R:P255	R:R:W256	2.7	No	No	0	2	3
221	R:R:A148	R:R:Y184	2.67	No	No	0	5	3
222	R:R:A179	R:R:Y251	2.67	No	Yes	0	1	3
223	R:R:N50	R:R:Q45	2.64	No	No	0	7	5
224	R:R:F260	R:R:S246	2.64	No	No	0	1	4
225	R:R:R14	R:R:V15	2.62	No	No	0	2	4
226	R:R:R263	R:R:V264	2.62	No	No	0	3	4
227	R:R:S138	R:R:Y55	2.54	No	Yes	0	7	7
228	R:R:S200	R:R:Y116	2.54	No	Yes	0	8	8
229	R:R:E215	R:R:E218	2.54	No	No	0	3	5
230	R:R:F95	R:R:L146	2.44	No	No	0	6	3
231	R:R:F125	R:R:L117	2.44	Yes	No	0	6	6
232	R:R:F125	R:R:L128	2.44	Yes	No	0	6	3
233	R:R:M57	R:R:Y43	2.39	Yes	No	0	5	4
234	R:R:D161	R:R:F167	2.39	No	Yes	0	2	4
235	R:R:D161	R:R:R162	2.38	No	No	0	2	4
236	R:R:D161	R:R:Y163	2.3	No	No	0	2	3
237	R:R:L183	R:R:W180	2.28	No	No	0	4	3
238	R:R:G8	R:R:P173	2.03	No	No	0	5	4
239	R:R:R254	R:R:W256	2	No	No	0	2	3
240	R:R:C9	R:R:G8	1.96	No	No	0	8	5
241	R:R:A38	R:R:P283	1.87	No	No	0	9	9
242	R:R:A238	R:R:P239	1.87	No	No	0	5	9
243	R:R:G31	R:R:V280	1.84	No	Yes	0	8	8
244	R:R:G189	R:R:V188	1.84	No	No	0	6	4
245	R:R:A38	R:R:C287	1.81	No	Yes	0	9	7
246	R:R:A41	R:R:C287	1.81	No	Yes	0	7	7
247	R:R:A293	R:R:C287	1.81	No	Yes	0	8	7
248	R:R:A120	R:R:A207	1.79	No	No	0	7	5
249	R:R:P239	R:R:S271	1.78	No	No	0	9	7
250	R:R:G88	R:R:K91	1.74	No	No	0	2	6
251	R:R:A38	R:R:S60	1.71	No	No	0	9	8
252	R:R:C109	R:R:V113	1.71	No	No	0	8	6
253	R:R:C110	R:R:V137	1.71	No	No	0	7	5
254	R:R:G147	R:R:L146	1.71	No	No	0	4	3
255	R:R:A106	R:R:V141	1.7	No	No	0	6	7
256	R:R:I28	R:R:P71	1.69	No	No	0	7	8
257	R:R:C68	R:R:T69	1.69	No	No	0	5	7
258	R:R:D257	R:R:G259	1.68	No	No	0	5	2
259	R:R:E7	R:R:G8	1.64	No	No	0	4	5
260	R:R:L32	R:R:P33	1.64	No	No	0	6	5
261	R:R:E291	R:R:G292	1.64	No	No	0	5	6
262	R:R:A62	R:R:I103	1.62	No	No	0	8	7
263	R:R:S139	R:R:V135	1.62	No	No	0	5	4
264	R:R:V131	R:R:V54	1.6	No	No	0	3	7
265	R:R:V119	R:R:V208	1.6	No	No	0	8	8
266	R:R:V131	R:R:V135	1.6	No	No	0	3	4
267	R:R:C36	R:R:L64	1.59	No	No	0	3	8
268	R:R:T133	R:R:V137	1.59	No	No	0	3	5
269	R:R:T144	R:R:V140	1.59	No	No	0	5	3
270	R:R:C236	R:R:L277	1.59	No	No	0	8	5
271	R:R:A267	R:R:L243	1.58	No	No	0	5	4
272	R:R:I222	R:R:V208	1.54	No	No	0	7	8
273	R:R:I284	R:R:V280	1.54	No	Yes	0	7	8
274	R:R:H121	R:R:P122	1.53	Yes	No	0	6	7
275	R:R:K219	R:R:V208	1.52	No	No	0	6	8
276	R:R:L225	R:R:S228	1.5	No	No	0	8	6
277	R:R:L243	R:R:S246	1.5	No	No	0	4	4
278	R:R:G253	R:R:R254	1.5	No	No	0	3	2
279	R:R:L78	R:R:V74	1.49	No	No	0	5	7
280	R:R:L245	R:R:V186	1.49	No	No	0	6	5
281	R:R:L225	R:R:V289	1.49	No	No	0	8	6
282	R:R:L158	R:R:T166	1.47	No	No	0	5	3
283	R:R:I230	R:R:L198	1.43	No	No	0	7	5
284	R:R:I222	R:R:L205	1.43	No	No	0	7	5
285	R:R:K223	R:R:L205	1.41	No	No	0	6	5
286	R:R:K223	R:R:L227	1.41	No	No	0	6	5
287	R:R:A118	R:R:R129	1.38	No	No	0	8	7
288	R:R:K221	R:R:Q217	1.36	No	No	0	7	4
289	R:R:E218	R:R:K221	1.35	No	No	0	5	7
290	R:R:F19	R:R:S22	1.32	Yes	No	0	5	5
291	R:R:D16	R:R:H17	1.26	Yes	No	0	5	5
292	R:R:I204	R:R:R115	1.25	No	No	0	8	9
293	R:R:K132	R:R:R130	1.24	No	No	0	4	6
294	R:R:F154	R:R:L153	1.22	No	No	0	4	4
295	R:R:E157	R:R:F159	1.17	No	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D16	5.8325	4	1	5
2	R:R:F19	4.2	4	0	5
3	R:R:P20	4.206	5	1	5
4	R:R:Y24	4.61833	6	1	9
5	R:R:N35	5.115	4	0	9
6	R:R:Y55	3.76	5	0	7
7	R:R:M57	2.87	4	0	5
8	R:R:Y66	6.325	4	0	7
9	R:R:W73	7.3825	4	1	7
10	R:R:Y76	7.716	5	1	6
11	R:R:F77	5.53	5	1	5
12	R:R:D81	6.0525	4	1	4
13	R:R:W83	5.13625	8	1	9
14	R:R:H85	5.09	5	1	7
15	R:R:F107	7.655	4	3	8
16	R:R:Y116	4.1175	4	2	8
17	R:R:H121	3.8	5	2	6
18	R:R:F125	4.2525	4	2	6
19	R:R:F167	6.2375	4	1	4
20	R:R:F169	8.848	5	0	4
21	R:R:E170	5.5925	4	1	4
22	R:R:F172	4.864	5	1	5
23	R:R:M174	5.165	4	1	1
24	R:R:N182	6.73	4	1	5
25	R:R:Y201	5.88	4	0	8
26	R:R:L229	4.425	4	0	8
27	R:R:F237	5.812	5	0	8
28	R:R:Y240	5.466	5	1	6
29	R:R:L244	6.5225	4	1	5
30	R:R:Y251	4.245	4	0	3
31	R:R:F265	8.382	5	1	4
32	R:R:H269	7.164	5	1	5
33	R:R:V280	2.45	4	0	8
34	R:R:D282	5.04	4	4	9
35	R:R:C287	2.15	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F172	R:R:F265	11.8368	7.5	Yes	Yes	1	5	4
2	R:R:E170	R:R:F172	17.2564	4.66	Yes	Yes	1	4	5
3	R:R:D16	R:R:H269	14.0519	6.3	Yes	Yes	1	5	5
4	R:R:F265	R:R:H269	14.3573	12.44	Yes	Yes	1	4	5
5	R:R:F265	R:R:S13	13.2049	5.28	Yes	No	0	4	5
6	R:R:D16	R:R:S13	10.3221	11.78	Yes	No	0	5	5
7	R:R:S13	R:R:S266	16.1204	4.89	No	No	0	5	2
8	R:R:R14	R:R:S266	10.7537	7.91	No	No	0	2	2
9	R:R:D16	R:R:H17	10.2569	1.26	Yes	No	0	5	5
10	R:R:E170	R:R:Y76	18.2459	4.49	Yes	Yes	1	4	6
11	R:R:F77	R:R:H269	31.4101	3.39	Yes	Yes	1	5	5
12	R:R:F77	R:R:Y24	25.1069	6.19	Yes	Yes	1	5	9
13	R:R:S276	R:R:Y24	13.0706	5.09	No	Yes	0	7	9
14	R:R:S276	R:R:V27	11.3441	6.46	No	No	0	7	7
15	R:R:L70	R:R:Y24	28.6249	5.86	No	Yes	0	8	9
16	R:R:W73	R:R:Y76	18.4902	8.68	Yes	Yes	1	7	6
17	R:R:F97	R:R:W73	47.3594	15.03	No	Yes	0	7	7
18	R:R:F97	R:R:Y66	47.673	8.25	No	Yes	0	7	7
19	R:R:C279	R:R:Y66	76.8394	5.38	No	Yes	0	9	7
20	R:R:C279	R:R:I67	14.5201	6.55	No	No	0	9	6
21	R:R:C279	R:R:D63	66.9001	6.22	No	No	0	9	9
22	R:R:D63	R:R:N35	29.9931	6.73	No	Yes	0	9	9
23	R:R:N35	R:R:P283	34.2807	8.15	Yes	No	0	9	9
24	R:R:R247	R:R:Y268	33.336	12.35	No	No	1	4	5
25	R:R:Y240	R:R:Y268	20.9536	7.94	Yes	No	1	6	5
26	R:R:T275	R:R:Y240	39.057	3.75	No	Yes	0	8	6
27	R:R:F237	R:R:T275	39.2443	3.89	Yes	No	0	8	8
28	R:R:F237	R:R:N278	50.7472	7.25	Yes	No	0	8	9
29	R:R:D282	R:R:N278	52.4085	9.42	Yes	No	0	9	9
30	R:R:D282	R:R:D63	75.1211	5.32	Yes	No	0	9	9
31	R:R:I67	R:R:N35	13.323	2.83	No	Yes	0	6	9
32	R:R:A38	R:R:P283	30.9988	1.87	No	No	0	9	9
33	R:R:A38	R:R:S60	15.8272	1.71	No	No	0	9	8
34	R:R:L39	R:R:S60	14.1007	4.5	No	No	0	7	8
35	R:R:L39	R:R:M57	12.3661	2.83	No	Yes	0	7	5
36	R:R:D282	R:R:L108	100	2.71	Yes	No	4	9	8
37	R:R:L108	R:R:Y286	99.9878	4.69	No	No	0	8	9
38	R:R:L229	R:R:Y286	99.4462	5.86	Yes	No	0	8	9
39	R:R:L229	R:R:Y201	95.7124	4.69	Yes	Yes	0	8	8
40	R:R:R115	R:R:Y201	79.3436	7.2	No	Yes	0	9	8
41	R:R:I111	R:R:R115	66.3178	3.76	No	No	0	9	9
42	R:R:I111	R:R:L52	12.2114	2.85	No	No	0	9	8
43	R:R:I111	R:R:Y55	55.3891	3.63	No	Yes	0	9	7
44	R:R:S138	R:R:Y55	41.1132	2.54	No	Yes	0	7	7
45	R:R:F107	R:R:S138	21.2468	3.96	Yes	No	3	8	7
46	R:R:N58	R:R:S138	18.7467	7.45	No	No	3	9	7
47	R:R:N58	R:R:W142	17.5536	5.65	No	No	3	9	9
48	R:R:F107	R:R:W142	17.6677	7.02	Yes	No	3	8	9
49	R:R:W83	R:R:Y76	11.1487	5.79	Yes	Yes	1	9	6
50	R:R:C168	R:R:W83	13.0828	7.84	No	Yes	1	9	9
51	R:R:I103	R:R:W142	32.7619	7.05	No	No	0	7	9
52	R:R:E145	R:R:I103	27.8106	4.1	No	No	0	7	7
53	R:R:E145	R:R:N149	25.3227	5.26	No	No	0	7	7
54	R:R:N149	R:R:T99	22.8267	5.85	No	No	0	7	5
55	R:R:F95	R:R:T99	20.3225	7.78	No	No	0	6	5
56	R:R:F95	R:R:L153	10.2244	13.4	No	No	0	6	4
57	R:R:C168	R:R:F169	12.0689	2.79	No	Yes	0	9	4
58	R:R:F190	R:R:F237	14.4387	5.36	No	Yes	0	8	8
59	R:R:F190	R:R:H241	12.5575	9.05	No	No	0	8	8
60	R:R:H241	R:R:Y102	11.9182	3.27	No	No	0	8	7
61	R:R:F237	R:R:I105	10.5827	6.28	Yes	No	0	8	8
62	R:R:S112	R:R:Y201	29.3009	7.63	No	Yes	0	9	8
63	R:R:S112	R:R:S200	20.807	6.52	No	No	0	9	8
64	R:R:S200	R:R:Y116	19.5611	2.54	No	Yes	0	8	8
65	R:R:H121	R:R:Y116	10.6478	4.36	Yes	Yes	2	6	8
66	R:R:I204	R:R:R115	19.4185	1.25	No	No	0	8	9
67	R:R:I204	R:R:V119	18.1848	4.61	No	No	0	8	8
68	R:R:L244	R:R:Y268	12.6471	3.52	Yes	No	1	5	5
69	R:R:L244	R:R:N182	25.5833	13.73	Yes	Yes	1	5	5
70	R:R:M174	R:R:N182	14.8907	2.8	Yes	Yes	1	1	5
71	R:R:M174	R:R:Y251	13.9216	7.18	Yes	Yes	0	1	3
72	R:R:V119	R:R:V208	16.9184	1.6	No	No	0	8	8
73	R:R:K219	R:R:V208	10.5949	1.52	No	No	0	6	8
74	R:R:S271	R:R:Y240	13.9338	5.09	No	Yes	0	7	6
75	R:R:A38	R:R:C287	14.1007	1.81	No	Yes	0	9	7
76	R:R:D81	R:R:Y76	12.5942	10.34	Yes	Yes	1	4	6
77	R:R:F172	R:R:R247	28.4458	3.21	Yes	No	1	5	4
78	R:R:L70	R:R:Y66	28.4784	5.86	No	Yes	0	8	7
79	R:R:F77	R:R:W73	14.5242	3.01	Yes	Yes	1	5	7
80	R:R:W73	R:R:W83	20.5464	2.81	Yes	Yes	1	7	9
81	R:R:L244	R:R:Y240	16.7271	5.86	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9BIP_nogp

PDB Summary
PDB	9BIP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.71
Number of Linked Nodes	265
Number of Links	295
Number of Hubs	35
Number of Links mediated by Hubs	128
Number of Communities	4
Number of Nodes involved in Communities	40
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	54171
Length Of Smallest Path	3
Average Path Length	14.6142
Length of Longest Path	32
Minimum Path Strength	1.355
Average Path Strength	5.43543
Maximum Path Strength	15.85
Minimum Path Correlation	0.7
Average Path Correlation	0.932686
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.7046
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.0902
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Biological Process
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell adhesion • regulation of cell adhesion • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • positive regulation of cell communication • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • Rho protein signal transduction • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • regulation of vascular permeability • circulatory system process • vascular process in circulatory system • regulation of biological quality • blood circulation • cellular developmental process • connective tissue development • mesangial cell development • cell development • epithelial cell differentiation • renal system development • kidney vasculature development • pericyte cell differentiation • renal system vasculature development • mesangial cell differentiation • cell differentiation • nephron development • epithelial cell differentiation involved in kidney development • blood vessel development • epithelium development • tissue development • glomerular mesangium development • glomerular mesangial cell development • vasculature development • glomerular mesangial cell differentiation • circulatory system development • glomerulus development • epithelial cell development • cell differentiation involved in kidney development • glomerulus vasculature development • kidney development • regulation of developmental process • negative regulation of biological process • angiogenesis • regulation of vasculature development • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • anatomical structure morphogenesis • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of multicellular organismal process • response to pH • response to abiotic stimulus • response to acidic pH • wound healing • angiogenesis involved in wound healing • response to wounding
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46093
Sequence	>9BIP_nogp_Chain_R E G C H V D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q R N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H D N W I H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H P L R F A R L R R V K T A V A V S S V V W A T E L G A N S A P L F H D E L F R D R Y N H T F C F E K F P M E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G S V S T E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P W D C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G A R S D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	10.1016/j.cell.2024.12.001
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZFJ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.1	2024-08-07	To be published
	8ZFJ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.1	2024-08-07	To be published
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	10.1016/j.cell.2024.12.001

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9BIP_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.