psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D16	R:R:F272	3.58	No	Yes	1	5	4
2	R:R:D16	R:R:H276	11.35	No	Yes	1	5	5
3	R:R:L19	R:R:P20	3.28	No	Yes	0	5	5
4	R:R:P20	R:R:P21	5.84	Yes	No	0	5	6
5	R:R:P20	R:R:Y24	4.17	Yes	Yes	1	5	8
6	R:R:P20	R:R:Y77	5.56	Yes	Yes	1	5	5
7	R:R:L78	R:R:P21	9.85	No	No	0	5	6
8	R:R:A280	R:R:L23	4.73	No	No	0	4	4
9	R:R:T74	R:R:Y24	7.49	No	Yes	0	7	8
10	R:R:Y24	R:R:Y77	8.94	Yes	Yes	1	8	5
11	R:R:T283	R:R:Y24	4.99	No	Yes	0	7	8
12	R:R:F28	R:R:I67	5.02	No	No	0	7	5
13	R:R:G31	R:R:L287	3.42	No	No	0	8	6
14	R:R:L32	R:R:P33	3.28	No	No	0	5	4
15	R:R:L32	R:R:L36	4.15	No	No	0	5	3
16	R:R:A34	R:R:P290	3.74	No	No	0	7	9
17	R:R:D63	R:R:N35	12.12	No	No	0	9	9
18	R:R:L64	R:R:N35	5.49	No	No	0	7	9
19	R:R:N35	R:R:P290	6.52	No	No	0	9	9
20	R:R:A38	R:R:C294	3.61	No	No	0	9	6
21	R:R:L39	R:R:L57	4.15	No	No	0	7	5
22	R:R:L39	R:R:S60	7.51	No	No	0	7	9
23	R:R:W40	R:R:W43	7.5	Yes	No	0	3	3
24	R:R:L44	R:R:W40	19.36	No	Yes	3	4	3
25	R:R:E303	R:R:W40	3.27	Yes	Yes	3	6	3
26	R:R:V307	R:R:W40	9.81	No	Yes	3	3	3
27	R:R:A41	R:R:E303	4.53	No	Yes	0	7	6
28	R:R:V46	R:R:W43	3.68	No	No	0	5	3
29	R:R:E303	R:R:L44	14.58	Yes	No	3	6	4
30	R:R:G53	R:R:Q45	4.93	No	No	0	7	5
31	R:R:K48	R:R:R47	3.71	No	No	0	5	6
32	R:R:E51	R:R:Y55	4.49	No	Yes	6	6	7
33	R:R:D114	R:R:E51	14.29	Yes	No	6	8	6
34	R:R:E51	R:R:P130	4.72	No	No	0	6	5
35	R:R:L52	R:R:V111	4.47	No	No	0	7	8
36	R:R:D114	R:R:L52	6.79	Yes	No	0	8	7
37	R:R:C110	R:R:Y55	6.72	No	Yes	0	6	7
38	R:R:D114	R:R:Y55	4.6	Yes	Yes	6	8	7
39	R:R:A134	R:R:Y55	5.34	No	Yes	0	8	7
40	R:R:L56	R:R:Y293	3.52	No	Yes	0	8	9
41	R:R:L57	R:R:N58	4.12	No	Yes	0	5	9
42	R:R:F107	R:R:N58	14.5	Yes	Yes	5	7	9
43	R:R:N58	R:R:S138	5.96	Yes	No	5	9	7
44	R:R:N58	R:R:W142	4.52	Yes	Yes	5	9	9
45	R:R:L108	R:R:L59	4.15	Yes	No	4	8	9
46	R:R:D289	R:R:L59	6.79	Yes	No	4	9	9
47	R:R:N100	R:R:S62	10.43	No	No	0	9	8
48	R:R:S62	R:R:V103	6.46	No	No	0	8	7
49	R:R:C286	R:R:D63	10.89	No	No	0	7	9
50	R:R:F97	R:R:L66	7.31	Yes	No	0	7	7
51	R:R:L66	R:R:N100	13.73	No	No	0	7	9
52	R:R:C286	R:R:L66	4.76	No	No	0	7	7
53	R:R:I67	R:R:L70	4.28	No	No	0	5	8
54	R:R:C286	R:R:I67	3.27	No	No	0	7	5
55	R:R:A69	R:R:V96	3.39	No	No	0	6	5
56	R:R:P71	R:R:P72	5.84	No	No	0	9	6
57	R:R:F93	R:R:P72	10.11	Yes	No	0	5	6
58	R:R:W73	R:R:Y76	6.75	No	Yes	0	6	6
59	R:R:G94	R:R:W73	4.22	No	No	0	6	6
60	R:R:D75	R:R:R79	7.15	No	No	0	4	4
61	R:R:D75	R:R:Y85	17.24	No	No	0	4	6
62	R:R:Y76	R:R:Y77	12.91	Yes	Yes	0	6	5
63	R:R:W83	R:R:Y76	4.82	Yes	Yes	0	8	6
64	R:R:E170	R:R:Y76	5.61	No	Yes	0	6	6
65	R:R:H276	R:R:Y77	20.69	Yes	Yes	1	5	5
66	R:R:R79	R:R:V82	3.92	No	No	0	4	4
67	R:R:D81	R:R:H165	10.08	No	Yes	0	4	3
68	R:R:A89	R:R:W83	3.89	No	Yes	2	5	8
69	R:R:C90	R:R:W83	7.84	Yes	Yes	2	9	8
70	R:R:F93	R:R:W83	8.02	Yes	Yes	2	5	8
71	R:R:C168	R:R:W83	5.22	No	Yes	2	9	8
72	R:R:G86	R:R:P87	4.06	No	No	0	8	3
73	R:R:I158	R:R:P87	3.39	No	No	0	4	3
74	R:R:A89	R:R:F93	4.16	No	Yes	2	5	5
75	R:R:A157	R:R:C90	3.61	No	Yes	0	4	9
76	R:R:C90	R:R:I158	3.27	Yes	No	0	9	4
77	R:R:C168	R:R:C90	7.28	No	Yes	2	9	9
78	R:R:L153	R:R:R91	7.29	No	Yes	2	4	7
79	R:R:A157	R:R:R91	5.53	No	Yes	0	4	7
80	R:R:R91	R:R:Y169	4.12	Yes	No	2	7	3
81	R:R:F95	R:R:T99	7.78	No	No	0	5	4
82	R:R:F95	R:R:L153	4.87	No	No	0	5	4
83	R:R:F97	R:R:Y98	8.25	Yes	No	0	7	5
84	R:R:F97	R:R:L279	7.31	Yes	No	0	7	6
85	R:R:F97	R:R:T283	3.89	Yes	No	0	7	7
86	R:R:Y241	R:R:Y98	4.96	Yes	No	0	7	5
87	R:R:N149	R:R:T99	10.24	No	No	0	6	4
88	R:R:L101	R:R:Y238	7.03	No	Yes	0	7	8
89	R:R:E145	R:R:Y102	5.61	No	Yes	0	7	7
90	R:R:N149	R:R:Y102	3.49	No	Yes	0	6	7
91	R:R:R186	R:R:Y102	4.12	Yes	Yes	0	6	7
92	R:R:H242	R:R:Y102	8.71	Yes	Yes	0	8	7
93	R:R:V103	R:R:W142	12.26	No	Yes	0	7	9
94	R:R:F107	R:R:S138	6.61	Yes	No	5	7	7
95	R:R:F107	R:R:I141	5.02	Yes	No	0	7	6
96	R:R:F107	R:R:W142	8.02	Yes	Yes	5	7	9
97	R:R:L108	R:R:M198	4.24	Yes	Yes	0	8	7
98	R:R:D289	R:R:L108	12.21	Yes	Yes	4	9	8
99	R:R:L108	R:R:Y293	5.86	Yes	Yes	4	8	9
100	R:R:P194	R:R:S109	3.56	No	No	0	9	7
101	R:R:S109	R:R:V197	4.85	No	No	0	7	6
102	R:R:R115	R:R:V111	6.54	No	No	0	9	8
103	R:R:M198	R:R:S112	6.13	Yes	No	0	7	9
104	R:R:C201	R:R:S112	5.16	Yes	No	0	7	9
105	R:R:S112	R:R:Y202	13.99	No	Yes	0	9	9
106	R:R:D114	R:R:F125	4.78	Yes	Yes	0	8	5
107	R:R:R115	R:R:Y202	8.23	No	Yes	0	9	9
108	R:R:A120	R:R:Y116	5.34	No	No	0	7	8
109	R:R:C201	R:R:Y116	6.72	Yes	No	0	7	8
110	R:R:F125	R:R:L117	13.4	Yes	No	0	5	6
111	R:R:L205	R:R:V119	11.92	No	No	0	8	8
112	R:R:A120	R:R:H121	4.39	No	No	0	7	6
113	R:R:F125	R:R:P126	11.56	Yes	No	0	5	5
114	R:R:P126	R:R:P130	5.84	No	No	0	5	5
115	R:R:R129	R:R:R132	7.46	No	No	0	7	4
116	R:R:P151	R:R:P152	5.84	No	No	0	8	4
117	R:R:L153	R:R:Y169	3.52	No	No	2	4	3
118	R:R:H159	R:R:S171	8.37	No	No	0	1	4
119	R:R:R160	R:R:T166	19.41	No	No	0	1	5
120	R:R:D161	R:R:H165	16.39	No	Yes	1	1	3
121	R:R:D161	R:R:F167	7.17	No	No	1	1	3
122	R:R:H165	R:R:Y163	4.36	Yes	No	0	3	2
123	R:R:F167	R:R:H165	7.92	No	Yes	1	3	3
124	R:R:F167	R:R:Y172	9.28	No	Yes	1	3	5
125	R:R:C168	R:R:Y169	4.03	No	No	2	9	3
126	R:R:E170	R:R:Y172	16.83	No	Yes	1	6	5
127	R:R:E170	R:R:H276	8.62	No	Yes	1	6	5
128	R:R:R248	R:R:Y172	9.26	Yes	Yes	1	5	5
129	R:R:E268	R:R:Y172	7.86	No	Yes	1	4	5
130	R:R:F272	R:R:Y172	6.19	Yes	Yes	1	4	5
131	R:R:H276	R:R:Y172	3.27	Yes	Yes	1	5	5
132	R:R:L174	R:R:R248	4.86	No	Yes	0	3	5
133	R:R:F252	R:R:L174	3.65	Yes	No	0	4	3
134	R:R:L253	R:R:R177	3.64	No	No	0	4	1
135	R:R:N183	R:R:R186	8.44	No	Yes	0	5	6
136	R:R:L245	R:R:N183	13.73	Yes	No	0	6	5
137	R:R:N183	R:R:S249	5.96	No	No	0	5	5
138	R:R:L245	R:R:V187	4.47	Yes	No	0	6	6
139	R:R:L246	R:R:V187	5.96	No	No	0	6	6
140	R:R:G190	R:R:P194	4.06	No	No	0	6	9
141	R:R:F191	R:R:W195	7.02	No	Yes	0	9	6
142	R:R:F191	R:R:Y238	4.13	No	Yes	1	9	8
143	R:R:F191	R:R:H242	13.58	No	Yes	1	9	8
144	R:R:L193	R:R:P194	4.93	No	No	0	5	9
145	R:R:M199	R:R:W195	3.49	No	Yes	0	4	6
146	R:R:L235	R:R:W195	14.81	No	Yes	0	5	6
147	R:R:M198	R:R:P231	10.06	Yes	No	0	7	7
148	R:R:M199	R:R:P231	5.03	No	No	0	4	7
149	R:R:A227	R:R:Y202	4	No	Yes	0	7	9
150	R:R:L230	R:R:Y202	3.52	No	Yes	0	7	9
151	R:R:P231	R:R:Y202	9.74	No	Yes	0	7	9
152	R:R:L206	R:R:V223	4.47	No	No	0	5	7
153	R:R:L206	R:R:R224	4.86	No	No	0	5	5
154	R:R:A227	R:R:L206	4.73	No	No	0	7	5
155	R:R:L209	R:R:R220	3.64	No	No	0	8	6
156	R:R:C215	R:R:S212	3.44	No	No	0	2	5
157	R:R:C215	R:R:R220	4.18	No	No	0	2	6
158	R:R:R218	R:R:R221	5.33	No	No	0	3	5
159	R:R:L228	R:R:R224	6.07	No	No	0	4	5
160	R:R:L226	R:R:L230	4.15	No	No	0	7	7
161	R:R:L230	R:R:Y293	9.38	No	Yes	0	7	9
162	R:R:L292	R:R:V233	4.47	No	No	0	7	6
163	R:R:C237	R:R:N285	9.45	No	Yes	0	8	9
164	R:R:H242	R:R:Y238	3.27	Yes	Yes	1	8	8
165	R:R:N285	R:R:Y238	9.3	Yes	Yes	0	9	8
166	R:R:G239	R:R:P240	4.06	No	No	0	6	9
167	R:R:H242	R:R:Y241	3.27	Yes	Yes	1	8	7
168	R:R:L245	R:R:Y241	3.52	Yes	Yes	1	6	7
169	R:R:Y241	R:R:Y275	12.91	Yes	Yes	1	7	6
170	R:R:S278	R:R:Y241	5.09	No	Yes	0	7	7
171	R:R:L279	R:R:Y241	8.21	No	Yes	0	6	7
172	R:R:L245	R:R:Y275	7.03	Yes	Yes	1	6	6
173	R:R:E268	R:R:R248	11.63	No	Yes	1	4	5
174	R:R:L271	R:R:R248	7.29	Yes	Yes	0	4	5
175	R:R:R248	R:R:Y275	12.35	Yes	Yes	1	5	6
176	R:R:C265	R:R:E269	4.56	No	No	0	6	2
177	R:R:F272	R:R:P273	4.33	Yes	No	0	4	3
178	R:R:F272	R:R:H276	14.71	Yes	Yes	1	4	5
179	R:R:H276	R:R:Y275	3.27	Yes	Yes	1	5	6
180	R:R:D289	R:R:N285	13.46	Yes	Yes	0	9	9
181	R:R:D289	R:R:Y293	6.9	Yes	Yes	4	9	9
182	R:R:C297	R:R:P298	3.77	No	No	0	7	6
183	R:R:E303	R:R:V307	5.7	Yes	No	3	6	3
184	R:R:A106	R:R:I141	3.25	No	No	0	6	6
185	R:R:S17	R:R:V18	3.23	No	No	0	4	4
186	R:R:A234	R:R:M198	3.22	No	Yes	0	9	7
187	R:R:V46	R:R:V54	3.21	No	No	0	5	6
188	R:R:T166	R:R:V82	3.17	No	No	0	5	4
189	R:R:A288	R:R:N285	3.13	No	Yes	0	6	9
190	R:R:R162	R:R:Y163	3.09	No	No	0	2	2
191	R:R:I131	R:R:V54	3.07	No	No	0	3	6
192	R:R:I141	R:R:V137	3.07	No	No	0	6	5
193	R:R:F252	R:R:G176	3.01	Yes	No	0	4	1
194	R:R:G211	R:R:R210	3	No	No	0	4	5
195	R:R:L244	R:R:S278	3	No	No	0	5	7
196	R:R:L70	R:R:V27	2.98	No	No	0	8	7
197	R:R:L37	R:R:V307	2.98	No	No	0	5	3
198	R:R:L181	R:R:V184	2.98	No	No	0	3	4
199	R:R:L188	R:R:V187	2.98	No	No	0	4	6
200	R:R:L209	R:R:V223	2.98	No	No	0	8	7
201	R:R:L146	R:R:T99	2.95	No	No	0	3	4
202	R:R:G204	R:R:Y116	2.9	No	No	0	4	8
203	R:R:W83	R:R:Y85	2.89	Yes	No	0	8	6
204	R:R:P152	R:R:R186	2.88	No	Yes	0	4	6
205	R:R:P298	R:R:R301	2.88	No	No	0	6	8
206	R:R:H165	R:R:S13	2.79	Yes	No	0	3	5
207	R:R:L19	R:R:L23	2.77	No	No	0	5	4
208	R:R:L36	R:R:L64	2.77	No	No	0	3	7
209	R:R:L61	R:R:L65	2.77	No	No	0	6	7
210	R:R:A180	R:R:F252	2.77	No	Yes	0	3	4
211	R:R:L181	R:R:L253	2.77	No	No	0	3	4
212	R:R:L281	R:R:L284	2.77	No	No	0	7	5
213	R:R:L56	R:R:Q45	2.66	No	No	0	8	5
214	R:R:V54	R:R:Y55	2.52	No	Yes	0	6	7
215	R:R:E156	R:R:H159	2.46	No	No	0	6	1
216	R:R:F93	R:R:L92	2.44	Yes	No	0	5	5
217	R:R:L271	R:R:R270	2.43	Yes	No	0	4	3
218	R:R:L292	R:R:Y293	2.34	No	Yes	0	7	9
219	R:R:L61	R:R:W142	2.28	No	Yes	0	6	9
220	R:R:L192	R:R:W195	2.28	No	Yes	0	4	6
221	R:R:F252	R:R:R177	2.14	Yes	No	0	4	1
222	R:R:R221	R:R:R225	2.13	No	No	0	5	5
223	R:R:G263	R:R:G264	2.11	No	No	0	2	3
224	R:R:G88	R:R:P87	2.03	No	No	0	2	3
225	R:R:G127	R:R:P126	2.03	No	No	0	4	5
226	R:R:G299	R:R:P298	2.03	No	No	0	6	6
227	R:R:C232	R:R:G229	1.96	No	No	0	4	5
228	R:R:A34	R:R:G31	1.95	No	No	0	7	8
229	R:R:A38	R:R:P290	1.87	No	No	0	9	9
230	R:R:A150	R:R:P151	1.87	No	No	0	3	8
231	R:R:G104	R:R:S62	1.86	No	No	0	9	8
232	R:R:G185	R:R:V184	1.84	No	No	0	3	4
233	R:R:A113	R:R:C201	1.81	No	Yes	0	5	7
234	R:R:A300	R:R:C294	1.81	No	No	0	8	6
235	R:R:A300	R:R:C297	1.81	No	No	0	8	7
236	R:R:A120	R:R:A208	1.79	No	No	0	7	5
237	R:R:P240	R:R:S278	1.78	No	No	0	9	7
238	R:R:G31	R:R:L30	1.71	No	No	0	8	5
239	R:R:A179	R:R:S175	1.71	No	No	0	3	3
240	R:R:C201	R:R:V197	1.71	Yes	No	0	7	6
241	R:R:C294	R:R:V304	1.71	No	No	0	6	6
242	R:R:L154	R:R:P151	1.64	No	No	0	4	8
243	R:R:E156	R:R:G155	1.64	No	No	0	6	3
244	R:R:L281	R:R:P240	1.64	No	No	0	7	9
245	R:R:S22	R:R:V18	1.62	No	No	0	3	4
246	R:R:A277	R:R:L19	1.58	No	No	0	5	5
247	R:R:A42	R:R:L56	1.58	No	No	0	6	8
248	R:R:A42	R:R:L57	1.58	No	No	0	6	5
249	R:R:A282	R:R:L101	1.58	No	No	0	8	7
250	R:R:A274	R:R:L244	1.58	No	No	0	4	5
251	R:R:H121	R:R:P122	1.53	No	No	0	6	8
252	R:R:G155	R:R:R91	1.5	No	Yes	0	3	7
253	R:R:L174	R:R:S171	1.5	No	No	0	3	4
254	R:R:G204	R:R:R207	1.5	No	No	0	4	4
255	R:R:G302	R:R:R301	1.5	No	No	0	4	8
256	R:R:L37	R:R:V308	1.49	No	No	0	5	4
257	R:R:L65	R:R:V96	1.49	No	No	0	7	5
258	R:R:L205	R:R:V223	1.49	No	No	0	8	7
259	R:R:L247	R:R:V251	1.49	No	No	0	5	4
260	R:R:G84	R:R:Y85	1.45	No	No	0	3	6
261	R:R:P130	R:R:R129	1.44	No	No	0	5	7
262	R:R:F252	R:R:P173	1.44	Yes	No	0	4	6
263	R:R:G196	R:R:W195	1.41	No	Yes	0	2	6
264	R:R:A118	R:R:F125	1.39	No	Yes	0	8	5
265	R:R:A182	R:R:R186	1.38	No	Yes	0	4	6
266	R:R:L247	R:R:L271	1.38	No	Yes	0	5	4
267	R:R:L267	R:R:L271	1.38	No	Yes	0	1	4
268	R:R:L295	R:R:R301	1.21	No	No	0	8	8
269	R:R:E219	R:R:R222	1.16	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P20	4.7125	4	1	5
2	R:R:Y24	6.3975	4	1	8
3	R:R:W40	9.985	4	3	3
4	R:R:Y55	4.734	5	6	7
5	R:R:N58	7.275	4	5	9
6	R:R:Y76	7.5225	4	0	6
7	R:R:Y77	12.025	4	1	5
8	R:R:W83	5.44667	6	2	8
9	R:R:C90	5.5	4	2	9
10	R:R:R91	4.61	4	2	7
11	R:R:F93	6.1825	4	2	5
12	R:R:F97	6.69	4	0	7
13	R:R:Y102	5.4825	4	0	7
14	R:R:F107	8.5375	4	5	7
15	R:R:L108	6.615	4	4	8
16	R:R:D114	7.615	4	6	8
17	R:R:F125	7.7825	4	0	5
18	R:R:W142	6.77	4	5	9
19	R:R:H165	8.308	5	1	3
20	R:R:Y172	8.78167	6	1	5
21	R:R:R186	4.205	4	0	6
22	R:R:W195	5.802	5	0	6
23	R:R:M198	5.9125	4	0	7
24	R:R:C201	3.85	4	0	7
25	R:R:Y202	7.896	5	0	9
26	R:R:Y238	5.9325	4	1	8
27	R:R:Y241	6.32667	6	1	7
28	R:R:H242	7.2075	4	1	8
29	R:R:L245	7.1875	4	1	6
30	R:R:R248	9.078	5	1	5
31	R:R:F252	2.602	5	0	4
32	R:R:L271	3.12	4	0	4
33	R:R:F272	7.2025	4	1	4
34	R:R:Y275	8.89	4	1	6
35	R:R:H276	10.3183	6	1	5
36	R:R:N285	8.835	4	0	9
37	R:R:D289	9.84	4	4	9
38	R:R:Y293	5.6	5	4	9
39	R:R:E303	7.02	4	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H276	R:R:Y77	26.2811	20.69	Yes	Yes	1	5	5
2	R:R:Y24	R:R:Y77	11.9164	8.94	Yes	Yes	1	8	5
3	R:R:T283	R:R:Y24	14.4204	4.99	No	Yes	0	7	8
4	R:R:F97	R:R:T283	15.7398	3.89	Yes	No	0	7	7
5	R:R:F97	R:R:L66	71.0105	7.31	Yes	No	0	7	7
6	R:R:C286	R:R:L66	54.7131	4.76	No	No	0	7	7
7	R:R:H276	R:R:Y275	49.482	3.27	Yes	Yes	1	5	6
8	R:R:Y241	R:R:Y275	74.1278	12.91	Yes	Yes	1	7	6
9	R:R:Y241	R:R:Y98	33.3984	4.96	Yes	No	0	7	5
10	R:R:F97	R:R:Y98	32.734	8.25	Yes	No	0	7	5
11	R:R:L279	R:R:Y241	33.3844	8.21	No	Yes	0	6	7
12	R:R:F97	R:R:L279	32.6458	7.31	Yes	No	0	7	6
13	R:R:C286	R:R:D63	44.6783	10.89	No	No	0	7	9
14	R:R:D63	R:R:N35	42.6434	12.12	No	No	0	9	9
15	R:R:N35	R:R:P290	32.3298	6.52	No	No	0	9	9
16	R:R:A38	R:R:P290	21.784	1.87	No	No	0	9	9
17	R:R:A38	R:R:C294	19.6469	3.61	No	No	0	9	6
18	R:R:H242	R:R:Y241	100	3.27	Yes	Yes	1	8	7
19	R:R:H242	R:R:Y238	32.1487	3.27	Yes	Yes	1	8	8
20	R:R:N285	R:R:Y238	31.1359	9.3	Yes	Yes	0	9	8
21	R:R:D289	R:R:N285	29.3798	13.46	Yes	Yes	0	9	9
22	R:R:D289	R:R:Y293	11.1452	6.9	Yes	Yes	4	9	9
23	R:R:L56	R:R:Y293	14.0256	3.52	No	Yes	0	8	9
24	R:R:A42	R:R:L56	11.4146	1.58	No	No	0	6	8
25	R:R:A42	R:R:L57	10.5738	1.58	No	No	0	6	5
26	R:R:F191	R:R:H242	70.964	13.58	No	Yes	1	9	8
27	R:R:F191	R:R:W195	71.4657	7.02	No	Yes	0	9	6
28	R:R:M199	R:R:W195	69.1614	3.49	No	Yes	0	4	6
29	R:R:M199	R:R:P231	68.7294	5.03	No	No	0	4	7
30	R:R:P231	R:R:Y202	52.3577	9.74	No	Yes	0	7	9
31	R:R:R115	R:R:Y202	34.4483	8.23	No	Yes	0	9	9
32	R:R:R115	R:R:V111	33.3937	6.54	No	No	0	9	8
33	R:R:L52	R:R:V111	32.2369	4.47	No	No	0	7	8
34	R:R:D114	R:R:L52	31.1638	6.79	Yes	No	0	8	7
35	R:R:D114	R:R:Y55	18.583	4.6	Yes	Yes	6	8	7
36	R:R:V54	R:R:Y55	15.0337	2.52	No	Yes	0	6	7
37	R:R:V46	R:R:V54	12.3577	3.21	No	No	0	5	6
38	R:R:V46	R:R:W43	11.0058	3.68	No	No	0	5	3
39	R:R:L66	R:R:N100	20.0836	13.73	No	No	0	7	9
40	R:R:N100	R:R:S62	18.4715	10.43	No	No	0	9	8
41	R:R:S62	R:R:V103	16.957	6.46	No	No	0	8	7
42	R:R:V103	R:R:W142	16.2462	12.26	No	Yes	0	7	9
43	R:R:D289	R:R:L108	16.9942	12.21	Yes	Yes	4	9	8
44	R:R:Y76	R:R:Y77	23.1359	12.91	Yes	Yes	0	6	5
45	R:R:W83	R:R:Y76	36.288	4.82	Yes	Yes	0	8	6
46	R:R:E170	R:R:H276	15.8606	8.62	No	Yes	1	6	5
47	R:R:E170	R:R:Y76	18.1974	5.61	No	Yes	0	6	6
48	R:R:W83	R:R:Y85	13.2311	2.89	Yes	No	0	8	6
49	R:R:F167	R:R:Y172	18.4855	9.28	No	Yes	1	3	5
50	R:R:F167	R:R:H165	13.2125	7.92	No	Yes	1	3	3
51	R:R:H276	R:R:Y172	11.7213	3.27	Yes	Yes	1	5	5
52	R:R:C90	R:R:W83	10.6016	7.84	Yes	Yes	2	9	8
53	R:R:H242	R:R:Y102	18.5366	8.71	Yes	Yes	0	8	7
54	R:R:M198	R:R:P231	17.4402	10.06	Yes	No	0	7	7
55	R:R:L108	R:R:M198	19.5679	4.24	Yes	Yes	0	8	7
56	R:R:M198	R:R:S112	31.0012	6.13	Yes	No	0	7	9
57	R:R:C201	R:R:S112	45.7329	5.16	Yes	No	0	7	9
58	R:R:C201	R:R:V197	16.6504	1.71	Yes	No	0	7	6
59	R:R:S109	R:R:V197	13.338	4.85	No	No	0	7	6
60	R:R:P194	R:R:S109	10.0163	3.56	No	No	0	9	7
61	R:R:S112	R:R:Y202	19.4332	13.99	No	Yes	0	9	9
62	R:R:A120	R:R:Y116	13.0267	5.34	No	No	0	7	8
63	R:R:C201	R:R:Y116	22.9361	6.72	Yes	No	0	7	8
64	R:R:A227	R:R:Y202	14.6992	4	No	Yes	0	7	9
65	R:R:A227	R:R:L206	13.3566	4.73	No	No	0	7	5
66	R:R:R248	R:R:Y172	12.4599	9.26	Yes	Yes	1	5	5
67	R:R:L174	R:R:R248	18.4623	4.86	No	Yes	0	3	5
68	R:R:R248	R:R:Y275	31.7166	12.35	Yes	Yes	1	5	6
69	R:R:F252	R:R:L174	13.0406	3.65	Yes	No	0	4	3
70	R:R:S278	R:R:Y241	11.1173	5.09	No	Yes	0	7	7
71	R:R:A300	R:R:C297	13.18	1.81	No	No	0	8	7
72	R:R:A300	R:R:C294	15.3449	1.81	No	No	0	8	6
73	R:R:C297	R:R:P298	11.0058	3.77	No	No	0	7	6
74	R:R:L230	R:R:Y293	10.5645	9.38	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8ZF7

PDB Summary
PDB	8ZF7
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR4
Species	Xenopus tropicalis
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.15
Date	2025-02-26
D.O.I.	doi.org/10.1016/j.cell.2024.12.001

Net Summary
I_min	3.27
Number of Linked Nodes	248
Number of Links	269
Number of Hubs	39
Number of Links mediated by Hubs	137
Number of Communities	6
Number of Nodes involved in Communities	42
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	44853
Length Of Smallest Path	3
Average Path Length	13.6066
Length of Longest Path	33
Minimum Path Strength	1.355
Average Path Strength	6.70324
Maximum Path Strength	17.7
Minimum Path Correlation	0.7
Average Path Correlation	0.929716
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	52.103
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.8789
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	A0A6I8PUB9
Sequence	>8ZF7_Chain_R S G L D S V L P P S L Y A L V F T L G L P A N L L A L W A A W L Q V R K G R E L G V Y L L N L S L S D L L L I C A L P P W T D Y Y L R R D V W G Y G P G A C R L F G F V F Y T N L Y V G A A F L S C V S A D R Y L A V A H P L R F P G A R P I R S A A A V S A L I W M L E L A A N A P P L L G E A I H R D R Y N H T F C Y E S Y P L S G R G A A L A N V G R V L A G F L L P W G V M M L C Y A G L L R A L R G S A S C E Q R E R R R V R R L A L G L P C V A L L C Y G P Y H A L L L L R S L V F L V G G C A L E E R L F P A Y H A S L A L A T L N C L A D P A L Y C L A C P G A R G E V A K V V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JCP	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.55	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCO (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.36	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC	chim(NtGi1-Gs)/β1/γ2	2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	9JCQ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	LPC		2.59	2025-07-09	doi.org/10.1038/s41421-025-00807-y
	8ZD1	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZD1 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.6	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF4	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.05	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF6 (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.98	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF7	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.15	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZF9 (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	chim(NtGi1-Gs)/β1/γ2	2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFA (No Gprot)	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-		2.96	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFB	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	3.78	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFC (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.68	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFD	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	8ZFE	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.56	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG	A	Orphan	Orphan	GPR4	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVG (No Gprot)	A	Orphan	Orphan	GPR4	Mus musculus	-	-		2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVH	A	Orphan	Orphan	GPR4	Mus musculus	-	-	-	2.76	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9JVM	A	Orphan	Orphan	GPR4	Xenopus tropicalis	-	-	-	2.36	2025-02-26	doi.org/10.1016/j.cell.2024.12.001
	9BIP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BIP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8ZCE	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCE (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.1	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZCF (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFU	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	3.23	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFV (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.67	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFW (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.13	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFX (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.87	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JFZ (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9JHP (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.35	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	9LGM (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.84	2025-04-23	doi.org/10.1038/s41422-025-01092-w
	8ZFZ	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8ZFZ (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.3	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31	A	Orphan	Orphan	GPR4	Danio rerio	-	-	chim(NtGi1-Gs)/β1/γ2	3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	9J31 (No Gprot)	A	Orphan	Orphan	GPR4	Danio rerio	-	-		3.05	2025-01-22	doi.org/10.1038/s41467-025-55901-2
	8Z3M	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-04-23	To be published
	8Z3M (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.9	2025-04-23	To be published
	8Z3Q	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.76	2025-04-23	To be published
	8Z3Q (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.76	2025-04-23	To be published
	8Z65	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-04-23	To be published
	8Z65 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.98	2025-04-23	To be published
	8Z66	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.06	2025-04-23	To be published
	8Z67	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-04-23	To be published
	9LMO	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	-	3.2	2025-07-09	To be published
	9LMP	A	Orphan	Orphan	GPR4	Homo sapiens	NE52-QQ57	-	-	2.65	2025-07-02	To be published
	8Z3Y	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2025-06-04	To be published
	8Z3Y (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		3.2	2025-06-04	To be published
	8Z9P	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gi1/β1/γ2	2.5	2025-07-09	To be published
	8Z9P (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.5	2025-07-09	To be published
	9IV6	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.71	2025-07-30	To be published
	9IV6 (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.71	2025-07-30	To be published
	8Z9O	A	Orphan	Orphan	GPR4	Homo sapiens	-	-	Gs/β1/γ2	2.4	2025-07-16	To be published
	8Z9O (No Gprot)	A	Orphan	Orphan	GPR4	Homo sapiens	-	-		2.4	2025-07-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZF7.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.