Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:D16 5.8725415
2R:R:P20 4.9225405
3R:R:Y24 5.295609
4R:R:N35 8.1275409
5R:R:Y55 5.47333627
6R:R:M57 2.425405
7R:R:D63 8.1325409
8R:R:Y66 7.22333607
9R:R:W73 8.784517
10R:R:Y76 8.504516
11R:R:F77 6.8725415
12R:R:D81 7.535414
13R:R:W83 5.64719
14R:R:H85 4.2425417
15R:R:K91 5.3775406
16R:R:F95 5.36406
17R:R:F97 9.69407
18R:R:I101 6.93408
19R:R:Y102 10.222537
20R:R:I111 3.826529
21R:R:E145 10.4325437
22R:R:N149 8.0225437
23R:R:E157 10.595405
24R:R:F167 7.06511
25R:R:E170 7.6375414
26R:R:F172 7.15167615
27R:R:Y201 5.52333608
28R:R:V208 2.69468
29R:R:L229 5.54408
30R:R:F237 8.018508
31R:R:Y240 7.508506
32R:R:H241 8.0225408
33R:R:R247 8.44714714
34R:R:Y251 2.4325403
35R:R:F260 7.58611
36R:R:R263 5.335413
37R:R:F265 6.015814
38R:R:H269 8.342515
39R:R:D282 8.085459
40R:R:C287 2.235408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F172 R:R:F260 38.37896.43YesYes151
2R:R:F167 R:R:F172 31.137.5YesYes115
3R:R:F265 R:R:S13 16.20732.64YesNo045
4R:R:D16 R:R:F265 13.67888.36YesYes154
5R:R:D16 R:R:F77 15.97623.58YesYes155
6R:R:F77 R:R:H269 20.25839.05YesYes155
7R:R:F265 R:R:H269 13.519110.18YesYes145
8R:R:E170 R:R:F172 34.45035.83YesYes145
9R:R:F77 R:R:P20 21.60078.67YesYes055
10R:R:F19 R:R:P20 23.81991.44NoYes055
11R:R:F19 R:R:L18 19.06882.44NoNo054
12R:R:A273 R:R:P20 16.79523.74NoYes055
13R:R:A273 R:R:Y24 26.80375.34NoYes059
14R:R:F77 R:R:Y24 44.16656.19YesYes059
15R:R:A273 R:R:L23 12.28553.15NoNo055
16R:R:L70 R:R:Y24 24.03064.69NoYes089
17R:R:F97 R:R:W73 79.364515.03YesYes077
18R:R:W73 R:R:Y76 63.54811.58YesYes176
19R:R:F167 R:R:Y76 37.93715.16YesYes116
20R:R:E170 R:R:Y76 31.77235.61YesYes146
21R:R:S276 R:R:Y24 22.61687.63NoYes079
22R:R:N35 R:R:P283 26.997414.66YesNo099
23R:R:D63 R:R:N35 33.726412.12YesYes099
24R:R:C279 R:R:D63 97.14539.34NoYes099
25R:R:C279 R:R:Y66 1006.72NoYes097
26R:R:F97 R:R:Y66 97.27449.28YesYes077
27R:R:A38 R:R:P283 18.69841.87NoNo099
28R:R:A38 R:R:C287 17.29143.61NoYes098
29R:R:D282 R:R:D63 78.89896.65YesYes099
30R:R:D282 R:R:L108 97.73665.43YesNo598
31R:R:L108 R:R:Y286 97.03315.86NoNo089
32R:R:I111 R:R:Y286 40.10886.04YesNo099
33R:R:I111 R:R:Y55 35.22853.63YesYes297
34R:R:A134 R:R:Y55 20.15635.34NoYes257
35R:R:A134 R:R:V54 18.91253.39NoNo055
36R:R:V46 R:R:V54 17.47836.41NoNo065
37R:R:M57 R:R:V46 16.03743.04YesNo056
38R:R:M57 R:R:Y43 11.67373.59YesNo054
39R:R:E145 R:R:I103 11.116416.4YesNo077
40R:R:E145 R:R:Y102 18.03917.86YesYes377
41R:R:I101 R:R:Y102 38.032313.3YesYes087
42R:R:I101 R:R:Y66 54.44014.84YesYes087
43R:R:W83 R:R:Y76 12.28558.68YesYes196
44R:R:C90 R:R:W83 11.02463.92NoYes199
45R:R:C90 R:R:E157 13.76389.12NoYes095
46R:R:F95 R:R:T99 11.955810.38YesNo065
47R:R:N149 R:R:Y102 11.43595.81YesYes377
48R:R:F237 R:R:I101 27.38155.02YesYes088
49R:R:I101 R:R:T275 18.93634.56YesNo088
50R:R:H241 R:R:Y102 10.16488.71YesYes087
51R:R:F237 R:R:I105 10.487712.56YesNo088
52R:R:L229 R:R:Y286 57.522510.55YesNo089
53R:R:L229 R:R:Y201 47.87774.69YesYes088
54R:R:A120 R:R:A207 16.18351.79NoNo073
55R:R:A207 R:R:V119 17.60751.7NoNo038
56R:R:I204 R:R:V119 18.47751.54NoNo668
57R:R:I204 R:R:Y201 33.86582.42NoYes068
58R:R:A120 R:R:Y116 14.7468.01NoNo078
59R:R:H121 R:R:Y116 11.85057.62NoNo068
60R:R:T275 R:R:Y240 17.61433.75NoYes086
61R:R:L244 R:R:Y240 17.69585.86NoYes056
62R:R:L244 R:R:N182 15.93215.1NoNo055
63R:R:N182 R:R:V178 10.59984.43NoNo052
64R:R:F172 R:R:Y268 27.38155.16YesNo055
65R:R:F260 R:R:R247 22.239614.97YesYes114
66R:R:R247 R:R:Y268 22.11727.2YesNo045
67R:R:A179 R:R:Y251 11.27271.33NoYes013
68R:R:R247 R:R:Y251 33.64153.09YesYes043
69R:R:I204 R:R:V208 14.03231.54NoYes668
70R:R:K219 R:R:V208 11.70774.55NoYes068
71R:R:K219 R:R:T214 10.39257.51NoNo063
72R:R:F237 R:R:N278 25.512313.29YesNo089
73R:R:W256 R:R:Y251 15.01783.86NoYes033
74R:R:A293 R:R:C287 11.71451.81NoYes088
75R:R:A293 R:R:N290 10.27363.13NoNo088
76R:R:P255 R:R:W256 11.27271.35NoNo023
77R:R:F97 R:R:Y24 25.09434.13YesYes079
78R:R:L70 R:R:Y66 24.23459.38NoYes087
79R:R:S276 R:R:Y66 22.71883.82NoYes077
80R:R:W73 R:R:W83 11.50726.56YesYes179
81R:R:D282 R:R:N278 24.754512.12YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z66
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.06
Date 2025-04-23
D.O.I. To be published
Net Summary
Imin 3.39
Number of Linked Nodes 279
Number of Links 314
Number of Hubs 40
Number of Links mediated by Hubs 146
Number of Communities 6
Number of Nodes involved in Communities 42
Number of Links involved in Communities 62
Path Summary
Number Of Nodes in MetaPath 82
Number Of Links MetaPath 81
Number of Shortest Paths 73663
Length Of Smallest Path 3
Average Path Length 13.2613
Length of Longest Path 29
Minimum Path Strength 1.31
Average Path Strength 6.65007
Maximum Path Strength 20.08
Minimum Path Correlation 0.7
Average Path Correlation 0.932532
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 52.2769
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.4189
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP46093
Sequence
>8Z66_Chain_R
GCHVDSRVD HLFPPSLYI VIGVGLPTN CLALWAAYR QVQQRNELG 
YLMLSIADL YICTLPWVD YFHHDNWIH GPGSCKLFF IFYTNIYIS 
IAFLCCIVD RYLAVAHPL RFRLRRVTV AVSSVVWAT ELGANSAPL 
FHDELFRDR YNHTCFEKF PMGWVAWMN LYRFVGFFP WAMLSYRLR 
VRGSVSTER QEKAKIKLA LSLAIVLVC FAPYHVLLS RSAIYGRPW 
DCGFEERVF SAYHSSAFT SLNCVDPIY LVNEGARSD AKALHNLFV 
NLLLGSAKA FVLLLGIAR ILLLALCV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z66.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.