Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:D16 6.1415
2R:R:Y24 5.938509
3R:R:I28 3.92557
4R:R:N35 5.255409
5R:R:L52 4.8275438
6R:R:Y55 5.9825407
7R:R:L56 4.6525438
8R:R:F77 8.3025415
9R:R:F107 7.5775488
10R:R:I111 4.6025439
11R:R:Y116 10.765428
12R:R:H121 5.1025426
13R:R:F125 6.6425406
14R:R:E157 7.7725495
15R:R:Y163 12.6575403
16R:R:F167 6.5975404
17R:R:F172 8.955415
18R:R:W177 15.7125401
19R:R:Y201 7.17408
20R:R:V208 3.4825408
21R:R:L229 5.052548
22R:R:F237 8.11408
23R:R:Y240 5.864506
24R:R:L243 3.0275404
25R:R:F265 11.058514
26R:R:V280 3.135408
27W:W:?1 9.31429700
28W:W:?2 9.49143720
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F167 R:R:F265 19.39584.29YesYes044
2R:R:F172 R:R:F265 38.75712.86YesYes154
3R:R:F265 R:R:H269 15.658811.31YesNo145
4R:R:F77 R:R:H269 17.20896.79YesNo155
5R:R:F77 R:R:Y24 12.79066.19YesYes059
6R:R:S276 R:R:Y24 14.87395.09NoYes079
7R:R:L70 R:R:Y24 24.910.55NoYes089
8R:R:V27 R:R:V280 10.93454.81NoYes078
9R:R:S276 R:R:V27 12.25758.08NoNo077
10R:R:I28 R:R:L70 27.10175.71YesNo078
11R:R:I28 R:R:I67 20.17575.89YesNo576
12R:R:C279 R:R:I67 18.92684.91NoNo096
13R:R:C279 R:R:D63 17.52977.78NoNo099
14R:R:D63 R:R:N35 16.12286.73NoYes099
15R:R:N35 R:R:P283 11.84288.15YesNo099
16R:R:D114 R:R:Y55 10.4266.9NoYes087
17R:R:C110 R:R:Y55 14.1635.38NoYes077
18R:R:C110 W:W:?1 15.392210.12NoYes070
19R:R:P193 W:W:?1 51.47366.98NoYes090
20R:R:F192 R:R:P193 52.45594.33NoNo059
21R:R:F192 R:R:L196 53.428412.18NoNo056
22R:R:L196 W:W:?2 55.34384.41NoYes060
23R:R:S200 W:W:?2 82.36166.38NoYes080
24R:R:S112 R:R:S200 82.9596.52NoNo098
25R:R:M197 R:R:S112 83.54646.13NoNo079
26R:R:I230 R:R:M197 84.1244.37NoNo077
27R:R:I230 R:R:Y201 85.22986.04NoYes078
28R:R:L229 R:R:Y201 81.97669.38YesYes088
29R:R:L229 R:R:Y286 84.78554.69YesNo089
30R:R:L108 R:R:Y286 95.96689.38NoNo089
31R:R:D282 R:R:L108 96.85059.5NoNo098
32R:R:D282 R:R:N278 97.12214.81NoNo099
33R:R:F237 R:R:N278 97.635413.29YesNo089
34R:R:F190 R:R:F237 98.74616.43NoYes088
35R:R:F190 R:R:H241 99.753228.28NoNo088
36R:R:H241 R:R:Y102 99.88155.44NoNo087
37R:R:R185 R:R:Y102 10012.35NoNo057
38R:R:N182 R:R:R185 99.70387.23NoNo055
39R:R:L244 R:R:N182 99.560616.48NoNo055
40R:R:L244 R:R:Y240 99.24475.86NoYes056
41R:R:Y240 R:R:Y268 58.37499.93YesNo065
42R:R:F172 R:R:Y268 34.41287.22YesNo155
43R:R:V137 R:R:Y55 14.20746.31NoYes057
44R:R:V137 W:W:?1 17.96.33NoYes050
45R:R:I111 R:R:Y286 11.51214.84YesNo099
46R:R:I111 R:R:L56 10.81114.28YesYes398
47R:R:A134 R:R:Y55 15.66375.34NoYes087
48R:R:A134 R:R:V54 13.0775.09NoNo087
49R:R:E145 W:W:?1 13.6218.3NoYes070
50R:R:L272 R:R:Y240 46.63574.69NoYes056
51R:R:F97 R:R:L272 45.75214.87NoNo075
52R:R:F97 R:R:Y66 44.063815.47NoNo077
53R:R:N100 R:R:Y66 10.93458.14NoNo087
54R:R:N149 R:R:R185 32.15184.82NoNo075
55R:R:N149 R:R:T99 31.036210.24NoNo075
56R:R:F95 R:R:T99 28.5587.78NoNo1065
57R:R:F95 R:R:L153 27.46717.05NoNo064
58R:R:K91 R:R:L153 23.80918.46NoNo064
59R:R:E157 R:R:K91 21.3215.4YesNo056
60R:R:C90 R:R:E157 16.16729.12NoYes995
61R:R:C90 R:R:W83 14.928211.75NoNo099
62R:R:L158 R:R:W83 10.9743.42NoNo059
63R:R:Y116 W:W:?2 35.449528.65YesYes280
64R:R:I204 R:R:Y116 23.60173.63NoYes088
65R:R:I204 R:R:V119 22.35777.68NoNo088
66R:R:M174 R:R:R247 30.57214.96NoNo014
67R:R:M174 R:R:V178 15.79216.09NoNo012
68R:R:V178 R:R:W177 14.385113.48NoYes021
69R:R:M174 R:R:Y251 14.607310.78NoNo013
70R:R:V119 R:R:V208 21.09391.6NoYes088
71R:R:T214 R:R:V208 17.44093.17NoYes038
72R:R:S271 R:R:Y240 14.89865.09NoYes076
73R:R:L243 R:R:S271 10.94443YesNo047
74R:R:E218 R:R:K221 10.89992.7NoNo057
75R:R:E218 R:R:T214 13.54591.41NoNo053
76R:R:L70 R:R:Y66 37.93268.21NoNo087
77R:R:R247 R:R:Y268 23.33518.23NoNo145
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C109 R:R:L196 4.76 0 No No 8 6 2 1
R:R:S112 R:R:S200 6.52 0 No No 9 8 2 1
R:R:A120 R:R:Y116 5.34 2 No Yes 7 8 2 1
R:R:H121 R:R:Y116 5.44 2 Yes Yes 6 8 2 1
R:R:Y116 W:W:?2 28.65 2 Yes Yes 8 0 1 0
R:R:A120 R:R:H121 4.39 2 No Yes 7 6 2 2
R:R:F192 R:R:L196 12.18 0 No No 5 6 2 1
R:R:L196 W:W:?2 4.41 0 No Yes 6 0 1 0
R:R:L199 W:W:?2 7.35 0 No Yes 5 0 1 0
R:R:S200 W:W:?2 6.38 0 No Yes 8 0 1 0
R:R:R202 R:R:R206 4.26 2 No No 3 3 1 1
R:R:R202 W:W:?2 9.04 2 No Yes 3 0 1 0
R:R:G203 W:W:?2 5.45 0 No Yes 4 0 1 0
R:R:R206 W:W:?2 5.16 2 No Yes 3 0 1 0
R:R:I204 R:R:Y116 3.63 0 No Yes 8 8 2 1
R:R:R206 R:R:R209 3.2 2 No No 3 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C110 R:R:Y55 5.38 0 No Yes 7 7 1 2
R:R:V137 R:R:Y55 6.31 0 No Yes 5 7 1 2
R:R:E145 R:R:I103 5.47 0 No No 7 7 1 2
R:R:A106 W:W:?1 6.7 0 No Yes 6 0 1 0
R:R:C110 W:W:?1 10.12 0 No Yes 7 0 1 0
R:R:V113 W:W:?1 9.5 0 No Yes 6 0 1 0
R:R:V137 W:W:?1 6.33 0 No Yes 5 0 1 0
R:R:E145 W:W:?1 18.3 0 No Yes 7 0 1 0
R:R:G189 W:W:?1 7.27 0 No Yes 6 0 1 0
R:R:F192 R:R:P193 4.33 0 No No 5 9 2 1
R:R:P193 W:W:?1 6.98 0 No Yes 9 0 1 0
R:R:G189 R:R:V188 3.68 0 No No 6 4 1 2
R:R:E145 R:R:T144 2.82 0 No No 7 5 1 2
R:R:T133 R:R:V137 1.59 0 No No 3 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9JCP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 4.24
Number of Linked Nodes 282
Number of Links 299
Number of Hubs 28
Number of Links mediated by Hubs 112
Number of Communities 10
Number of Nodes involved in Communities 44
Number of Links involved in Communities 50
Path Summary
Number Of Nodes in MetaPath 78
Number Of Links MetaPath 77
Number of Shortest Paths 40468
Length Of Smallest Path 3
Average Path Length 19.2878
Length of Longest Path 43
Minimum Path Strength 1.34
Average Path Strength 8.2455
Maximum Path Strength 23.14
Minimum Path Correlation 0.7
Average Path Correlation 0.928562
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 44.2203
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 25.8084
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_W_
PDB ResiduesW:W:?1 W:W:?2
Environment DetailsOpen EMBL-EBI Page
Code_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JCP_nogp_Chain_R
GCHVDSRVD HLFPPSLYI FVIGVGLPT NCLALWAAY RQVQQRNEL 
GVYLMNLSI ADLLYICTL PLWVDYFLH HDNWIHGPG SCKLFGFIF 
YTNIYISIA FLCCISVDR YLAVAHPLR FARLRRVKT AVAVSSVVW 
ATELGANSA PLFHDELFR DRYNHTFCF EKFPMEGWV AWMNLYRVF 
VGFLFPWAL MLLSYRGIL RAVRGSVST ERQEKAKIK RLALSLIAI 
VLVCFAPYH VLLLSRSAI YLGRPWDCG FEERVFSAY HSSLAFTSL 
NCVADPILY CLVNEGARS DVAKALHN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JCP_nogp.zip



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