Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 8.7275444
2A:A:Y37 7.1045204
3A:A:H41 5.3275406
4A:A:L45 4.9075488
5A:A:S51 3.88754149
6A:A:F219 7.785458
7A:A:F222 11.3625167
8A:A:D223 5.7425489
9A:A:W234 7.4075429
10A:A:F238 8.2565169
11A:A:I244 4.7375408
12A:A:I245 4.1875487
13A:A:F246 6.15539
14A:A:V248 4.2437
15A:A:D249 6.3954148
16A:A:Y253 9.716676128
17A:A:F273 8.9725439
18A:A:W281 12.8825425
19A:A:L289 5.934539
20A:A:F290 8.44167689
21A:A:L291 6.5538
22A:A:N292 4.4954149
23A:A:K293 3.9175409
24A:A:F312 3.9125438
25A:A:F315 8.725126
26A:A:E327 5.2725404
27A:A:D331 5.215404
28A:A:K338 6.68435
29A:A:Y339 6.8725433
30A:A:F340 4.625437
31A:A:R342 10.15434
32A:A:E344 7.754535
33A:A:F345 7.236538
34A:A:H357 7.725407
35A:A:Y360 8.636108
36A:A:F363 6.85635
37A:A:T364 7.1575489
38A:A:N371 10.42489
39A:A:I375 4.1775489
40A:A:F376 5.68558
41A:A:D381 5.10754108
42A:A:I382 3.95254106
43A:A:I383 4.795458
44A:A:L388 3.59754228
45A:A:Y391 6.86654
46B:B:L7 4.165408
47B:B:L30 6.8425185
48B:B:V40 4.425673
49B:B:M45 4.7925474
50B:B:H54 5.72333649
51B:B:K57 11.4429
52B:B:M61 4.3325446
53B:B:W63 9.4225447
54B:B:L69 5.45545
55B:B:D76 6.85754209
56B:B:K78 4.37408
57B:B:L79 5.7225407
58B:B:I81 4.255447
59B:B:W82 7.67714749
60B:B:D83 8.042548
61B:B:N88 9.7175447
62B:B:K89 8.362549
63B:B:I93 6.9154267
64B:B:L95 5.2875408
65B:B:W99 9.9585169
66B:B:Y105 5.444546
67B:B:C121 4.135428
68B:B:Y124 3.8525266
69B:B:R137 7.8875405
70B:B:H142 7.058529
71B:B:Y145 5.94628
72B:B:L146 3.06427
73B:B:C149 3.3925428
74B:B:F151 4.45409
75B:B:L152 5.53493
76B:B:V158 3.958595
77B:B:T159 5.222529
78B:B:S161 7.4575429
79B:B:D163 9.48429
80B:B:W169 8.576508
81B:B:I171 6.2425406
82B:B:F180 7.408597
83B:B:H183 8.295499
84B:B:D186 4.95429
85B:B:L190 4.65495
86B:B:F199 6.715699
87B:B:V200 7.24466
88B:B:C204 5.9275427
89B:B:D205 5.355409
90B:B:K209 11.5325496
91B:B:W211 8.748598
92B:B:Q220 4.0775467
93B:B:F222 6.5275468
94B:B:H225 9.92769
95B:B:I232 5.7275468
96B:B:F234 4.7375405
97B:B:F235 9.748577116
98B:B:N237 10.054115
99B:B:F241 8.114566
100B:B:T243 5.1775468
101B:B:S245 7.085469
102B:B:D247 7.162569
103B:B:T249 6.2075466
104B:B:R251 10.6833668
105B:B:L252 3.99254187
106B:B:F253 5.98667666
107B:B:D258 8.43467
108B:B:L261 3.58754185
109B:B:Y264 6.696505
110B:B:I273 5.06754156
111B:B:F278 5.54754117
112B:B:L284 5.095475
113B:B:Y289 9.54754157
114B:B:D290 11.885426
115B:B:N295 10.88754156
116B:B:W297 6.9854158
117B:B:L300 4.92406
118B:B:K301 5.35405
119B:B:R304 7.34754155
120B:B:H311 9.18833679
121B:B:R314 15.308528
122B:B:L318 5.1825406
123B:B:M325 6.00754175
124B:B:W332 14.28529
125B:B:D333 7.885479
126B:B:K337 10.52476
127B:B:W339 7.37667679
128G:G:L15 4.99754232
129G:G:L19 4.88754239
130G:G:Y40 11.93754116
131G:G:D48 5.905409
132G:G:V54 4.0765176
133G:G:N59 6.9325409
134G:G:P60 6.955409
135G:G:F61 5.7945258
136R:R:D16 6.69415
137R:R:P20 6.0625415
138R:R:Y24 6.00167619
139R:R:N35 7.5945289
140R:R:R44 6.548504
141R:R:Q45 4.4675455
142R:R:E51 6.93457
143R:R:Y55 4.7025407
144R:R:N58 7.724197
145R:R:Y66 5.09833617
146R:R:L70 7.63418
147R:R:W73 9.89667617
148R:R:Y76 5.716516
149R:R:F77 8.498515
150R:R:W83 9.056519
151R:R:F95 4.4885306
152R:R:I96 4.17405
153R:R:F97 10.162517
154R:R:Y102 5.215407
155R:R:I103 5.0425407
156R:R:F107 6.90254198
157R:R:L108 7.255408
158R:R:D114 5.91458
159R:R:Y116 4.9954138
160R:R:H121 8.82754136
161R:R:L123 4.2375456
162R:R:F125 6.5154136
163R:R:R129 8.0575457
164R:R:P152 3.7375403
165R:R:D161 6.38412
166R:R:H165 7.938511
167R:R:F167 7.362511
168R:R:F169 9.675414
169R:R:F172 8.73415
170R:R:P173 5.8825414
171R:R:M174 4.98411
172R:R:W177 10.3275411
173R:R:V178 4.2625412
174R:R:N182 4.438515
175R:R:R185 6.005405
176R:R:Y201 6.3556318
177R:R:S211 4.53754105
178R:R:S213 7.08754103
179R:R:L229 5.99254318
180R:R:C236 4.4625418
181R:R:F237 5.77571718
182R:R:Y240 6.95167616
183R:R:H241 8.6408
184R:R:L244 6.645415
185R:R:R247 6.9125404
186R:R:Y251 3.938503
187R:R:F260 10.065401
188R:R:F265 8.154514
189R:R:Y268 6.866515
190R:R:H269 7.045615
191R:R:T275 3.4075418
192R:R:N278 8.248519
193R:R:Y286 6.91754319
194R:R:C287 2.062508
195R:R:N290 5.485408
196R:R:G292 3.31406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N23 B:B:N88 11.13628.17NoYes477
2A:A:N23 B:B:K89 11.35289.79NoYes479
3B:B:D76 B:B:K78 12.1655.53YesYes098
4A:A:Y37 B:B:D76 21.43663.45YesYes2049
5A:A:R42 A:A:Y37 21.927114.4NoYes094
6A:A:I383 A:A:M386 92.45225.83YesNo083
7A:A:I382 A:A:M386 92.50354.37YesNo063
8A:A:I382 A:A:S286 87.65256.19YesNo1068
9A:A:H357 A:A:S286 99.54172.79YesNo078
10A:A:H357 A:A:W277 99.75125.39YesNo076
11A:A:S349 A:A:W277 1006.18NoNo076
12A:A:C359 A:A:S349 98.93136.89NoNo057
13A:A:C359 A:A:L289 98.97243.17NoYes059
14A:A:L289 A:A:V248 48.90954.47YesYes397
15A:A:F246 A:A:V248 51.39173.93YesYes397
16A:A:F246 A:A:I276 34.42313.77YesNo098
17A:A:I276 A:A:L282 34.35295.71NoNo089
18A:A:I244 A:A:L282 34.2234.28YesNo089
19A:A:I244 A:A:L44 34.09125.71YesNo089
20A:A:F238 A:A:L44 34.047421.92YesNo099
21A:A:F222 A:A:F238 21.87743.22YesYes1679
22A:A:F222 A:A:R42 22.22954.28YesNo079
23A:A:F273 A:A:L289 48.91097.31YesYes399
24A:A:F246 A:A:F273 49.56879.65YesYes399
25A:A:D378 A:A:Y360 15.048813.79NoYes078
26A:A:S286 A:A:Y360 11.84728.9NoYes1088
27A:A:I245 A:A:L45 11.99092.85YesYes878
28A:A:L46 A:A:R231 66.463.64NoNo089
29A:A:R231 A:A:W234 66.36179NoYes099
30B:B:K127 B:B:N110 13.11964.2NoNo044
31B:B:N110 B:B:Y111 13.60379.3NoNo044
32B:B:I123 B:B:Y111 13.76733.63NoNo064
33B:B:I123 B:B:R137 14.76037.52NoYes065
34B:B:L139 B:B:R137 15.07328.5NoYes095
35B:B:H142 B:B:T159 33.55885.48YesYes299
36B:B:H142 B:B:S161 34.008613.95YesYes299
37B:B:G162 B:B:S161 34.85083.71NoYes299
38B:B:G162 B:B:Y145 34.49622.9NoYes298
39B:B:M101 B:B:Y145 12.41724.79NoYes098
40A:A:K233 B:B:M188 18.9955.76NoNo298
41B:B:M188 B:B:Y145 19.58194.79NoYes288
42A:A:Q236 B:B:R314 18.58865.84NoYes288
43B:B:Q75 B:B:W99 11.9944.38NoYes099
44B:B:K57 B:B:Q75 23.609512.2YesNo099
45B:B:K57 B:B:W332 23.102620.89YesYes299
46B:B:R314 B:B:W332 11.812423.99YesYes289
47B:B:Q75 B:B:Y59 11.80139.02NoNo098
48A:A:I383 A:A:N387 91.15094.25YesNo588
49A:A:N387 R:R:A118 30.4234.69NoNo588
50A:A:N387 R:R:R129 60.67513.62NoYes587
51R:R:I111 R:R:Y286 74.39478.46NoYes099
52R:R:I111 R:R:L56 74.64425.71NoNo098
53R:R:L52 R:R:L56 74.79144.15NoNo588
54R:R:D114 R:R:L52 87.37486.79YesNo588
55A:A:Y391 R:R:D114 60.21613.45YesYes548
56A:A:Y391 R:R:A118 30.34849.34YesNo548
57A:A:Y391 R:R:R129 30.348410.29YesYes547
58R:R:D114 R:R:E51 30.11346.5YesYes587
59R:R:E51 R:R:R129 30.262912.79YesYes577
60R:R:L52 R:R:Q45 12.33683.99NoYes585
61A:A:N392 R:R:Q45 11.64576.6NoYes075
62A:A:N392 R:R:N290 11.387210.9NoYes078
63B:B:C148 B:B:T102 18.26123.38NoNo068
64B:B:C148 B:B:L190 17.54434.76NoYes065
65B:B:F199 B:B:L190 15.55114.87YesYes995
66B:B:F199 B:B:W211 14.190910.02YesYes998
67B:B:K209 B:B:W211 10.95958.12YesYes968
68B:B:K209 B:B:T221 10.897713.51YesNo067
69B:B:R22 B:B:T221 10.57623.88NoNo067
70B:B:H91 B:B:V90 10.87969.69NoNo055
71B:B:H91 B:B:V133 10.04985.54NoNo054
72B:B:W297 B:B:Y264 23.43548.68YesYes085
73B:B:N295 B:B:W297 23.60785.65YesYes1568
74B:B:N295 B:B:V307 32.77045.91YesNo063
75B:B:N293 B:B:V307 33.48044.43NoNo053
76B:B:N313 B:B:W332 34.21917.91NoYes079
77R:R:L108 R:R:Y286 66.36417.03YesYes089
78R:R:D282 R:R:L108 62.36612.21NoYes098
79R:R:D282 R:R:N278 62.11419.42NoYes099
80R:R:F237 R:R:N278 57.718110.87YesYes189
81R:R:F237 R:R:T275 31.37663.89YesYes188
82R:R:T275 R:R:Y240 29.13.75YesYes186
83R:R:Y240 R:R:Y268 22.69412.98YesYes165
84R:R:F237 R:R:I101 19.22013.77YesNo188
85R:R:I101 R:R:Y66 19.01743.63NoYes187
86R:R:H269 R:R:Y268 10.19417.62YesYes155
87B:B:F292 B:B:N313 33.96271.21NoNo047
88B:B:F292 B:B:N293 33.71911.21NoNo045
89A:A:F246 A:A:L46 66.50954.87YesNo098
90A:A:W234 B:B:Y145 65.7753.86YesYes298
91B:B:L252 B:B:Y264 12.68823.52YesYes075
92A:A:F238 B:B:W99 11.98148.02YesYes1699
93A:A:K233 A:A:Q236 19.30164.07NoNo298
94B:B:M101 B:B:Y59 11.91458.38NoNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9JFV
Class A
SubFamily Orphan
Type Orphan
SubType GPR4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.67
Date 2025-04-23
D.O.I. doi.org/10.1038/s41422-025-01092-w
Net Summary
Imin 2.79
Number of Linked Nodes 874
Number of Links 1099
Number of Hubs 196
Number of Links mediated by Hubs 681
Number of Communities 32
Number of Nodes involved in Communities 294
Number of Links involved in Communities 415
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 3887932
Length Of Smallest Path 3
Average Path Length 39.5905
Length of Longest Path 62
Minimum Path Strength 1.07
Average Path Strength 6.64246
Maximum Path Strength 22.44
Minimum Path Correlation 0.71
Average Path Correlation 0.993845
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 38.028
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.9237
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell adhesion   • regulation of cell adhesion   • regulation of defense response   • regulation of response to external stimulus   • defense response   • positive regulation of biological process   • response to external stimulus   • regulation of inflammatory response   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • positive regulation of inflammatory response   • regulation of response to stimulus   • regulation of response to stress   • response to stress   • positive regulation of defense response   • inflammatory response   • phospholipase C-activating G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • regulation of vascular permeability   • multicellular organismal process   • system process   • circulatory system process   • vascular process in circulatory system   • regulation of biological quality   • blood circulation   • cellular developmental process   • connective tissue development   • mesangial cell development   • cell development   • epithelial cell differentiation   • renal system development   • kidney vasculature development   • multicellular organism development   • pericyte cell differentiation   • renal system vasculature development   • mesangial cell differentiation   • cell differentiation   • anatomical structure development   • nephron development   • system development   • epithelial cell differentiation involved in kidney development   • blood vessel development   • developmental process   • epithelium development   • animal organ development   • tissue development   • glomerular mesangium development   • glomerular mesangial cell development   • vasculature development   • glomerular mesangial cell differentiation   • circulatory system development   • glomerulus development   • epithelial cell development   • cell differentiation involved in kidney development   • glomerulus vasculature development   • kidney development   • regulation of developmental process   • negative regulation of biological process   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • anatomical structure morphogenesis   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • negative regulation of multicellular organismal process   • response to pH   • response to abiotic stimulus   • response to acidic pH   • wound healing   • angiogenesis involved in wound healing   • response to wounding   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • ectodermal placode formation   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell-cell adhesion   • coagulation   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9JFV_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGASGKST 
IVKQMRSGI FETKFQVDK VNFHMFDVG GQRDERRKW IQCFNDVTA 
IIFVVSSYN RLQEALNLF KSIWNNRWL RTISVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTASGD GRHYCYPHF TCAVDTENR RFNDCDIIM LRYLDNDDA 
IKLQNENV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JFV_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JFV_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46093
Sequence
>9JFV_Chain_R
GCHVDSRVD HLFPPSLYI VIGVGLPTN CLALWAAYR QVQQRNELG 
YLMLSIADL YICTLPWVD YFHHDNWIH GPGSCKLFF IFYTNIYIS 
IAFLCCIVD RYLAVAHPL RFRLRRVTV AVSSVVWAT ELGANSAPL 
FHDELFRDR YNHTCFEKF PMEGWVAWM NLYRFVGFF PWAMLSYRL 
RVRGSVSTE RQEKAKIKL ALSLAIVLV CFAPYHVLL SRSAIYGRP 
WDCGFEERV FSAYHSSAF TSLNCVDPI YLVNEGARS DAKAFVNLL 
LGSAKAFVL LLGIARILL LALCV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCP (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCO (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQ (No Gprot) AOrphanOrphanGPR4Homo sapiens-LPC2.592025-07-09doi.org/10.1038/s41421-025-00807-y
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZD1 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF4AOrphanOrphanGPR4Xenopus tropicalis---3.052025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6 (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF7AOrphanOrphanGPR4Xenopus tropicalis---3.152025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9 (No Gprot) AOrphanOrphanGPR4Mus musculus--2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFA (No Gprot) AOrphanOrphanGPR4Xenopus tropicalis--2.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFBAOrphanOrphanGPR4Xenopus tropicalis---3.782025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFC (No Gprot) AOrphanOrphanGPR4Mus musculus--2.682025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFDAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFEAOrphanOrphanGPR4Mus musculus---2.562025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVG (No Gprot) AOrphanOrphanGPR4Mus musculus--2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVHAOrphanOrphanGPR4Mus musculus---2.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVMAOrphanOrphanGPR4Xenopus tropicalis---2.362025-02-26doi.org/10.1016/j.cell.2024.12.001
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BIP (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCE (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCF (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFUAOrphanOrphanGPR4Homo sapiensNE52-QQ57--3.232025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFV (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFW (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFX (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZ (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9JHP (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
9LGM (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.842025-04-23doi.org/10.1038/s41422-025-01092-w
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
8ZFZ (No Gprot) AOrphanOrphanGPR4Danio rerio--3.32025-01-22doi.org/10.1038/s41467-025-55901-2
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9J31 (No Gprot) AOrphanOrphanGPR4Danio rerio--3.052025-01-22doi.org/10.1038/s41467-025-55901-2
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3M (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z3Q (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8Z65 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.982025-04-23To be published
8Z66AOrphanOrphanGPR4Homo sapiens---3.062025-04-23To be published
8Z67AOrphanOrphanGPR4Homo sapiens---3.22025-04-23To be published
9LMOAOrphanOrphanGPR4Homo sapiens---3.22025-07-09To be published
9LMPAOrphanOrphanGPR4Homo sapiensNE52-QQ57--2.652025-07-02To be published
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
8Z3Y (No Gprot) AOrphanOrphanGPR4Homo sapiens--3.22025-06-04To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
8Z9P (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.52025-07-09To be published
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IV6 (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.712025-07-30To be published
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
8Z9O (No Gprot) AOrphanOrphanGPR4Homo sapiens--2.42025-07-16To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JFV.zip



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