psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:K2	6.1	Yes	No	0	0	0
2	L:L:?1	L:L:P3	2.84	Yes	No	6	0	0
3	L:L:?1	R:R:V176	2.58	Yes	No	6	0	4
4	L:L:?1	R:R:R178	18.92	Yes	No	6	0	2
5	L:L:?1	R:R:L187	10.78	Yes	No	6	0	4
6	L:L:?1	R:R:G189	5.92	Yes	No	0	0	4
7	L:L:?1	R:R:D191	17.61	Yes	No	0	0	4
8	L:L:?1	R:R:P270	2.84	Yes	No	0	0	3
9	L:L:K2	R:R:E199	6.75	No	No	0	0	4
10	L:L:K2	R:R:F275	8.69	No	Yes	0	0	3
11	L:L:P3	R:R:L187	9.85	No	No	6	0	4
12	L:L:?4	L:L:?5	25.53	Yes	Yes	1	0	0
13	L:L:?4	L:L:?6	2.08	Yes	Yes	1	0	0
14	L:L:?4	R:R:L92	6.5	Yes	No	1	0	6
15	L:L:?4	R:R:P113	3.09	Yes	No	1	0	6
16	L:L:?4	R:R:R175	5.71	Yes	Yes	1	0	5
17	L:L:?5	L:L:?6	31.09	Yes	Yes	1	0	0
18	L:L:?5	R:R:L92	2.36	Yes	No	1	0	6
19	L:L:?5	R:R:I116	6.09	Yes	No	0	0	6
20	L:L:?5	R:R:L117	2.36	Yes	No	0	0	4
21	L:L:?5	R:R:V286	3.81	Yes	Yes	1	0	5
22	L:L:?6	R:R:V190	3.57	Yes	No	0	0	5
23	L:L:?6	R:R:Y258	15.9	Yes	Yes	1	0	7
24	L:L:?6	R:R:D282	10.83	Yes	No	0	0	4
25	L:L:?6	R:R:V286	2.38	Yes	Yes	1	0	5
26	R:R:P36	R:R:R34	4.32	No	No	0	3	2
27	R:R:D37	R:R:R34	2.38	No	No	0	4	2
28	R:R:K280	R:R:R34	17.33	No	No	0	2	2
29	R:R:P36	R:R:V35	3.53	No	No	0	3	3
30	R:R:L284	R:R:P36	3.28	No	No	0	4	3
31	R:R:I43	R:R:L39	2.85	Yes	No	0	5	5
32	R:R:A40	R:R:F44	2.77	No	Yes	1	6	7
33	R:R:A40	R:R:S283	3.42	No	No	1	6	4
34	R:R:A40	R:R:L284	3.15	No	No	0	6	4
35	R:R:F93	R:R:L41	9.74	No	No	0	7	5
36	R:R:I43	R:R:S287	7.74	Yes	No	0	5	4
37	R:R:I291	R:R:I43	4.42	Yes	Yes	3	5	5
38	R:R:F44	R:R:L89	7.31	Yes	No	0	7	7
39	R:R:F44	R:R:I96	3.77	Yes	No	0	7	5
40	R:R:F44	R:R:S283	2.64	Yes	No	1	7	4
41	R:R:F44	R:R:V286	2.62	Yes	Yes	1	7	5
42	R:R:F44	R:R:S287	14.53	Yes	No	0	7	4
43	R:R:C294	R:R:V47	5.12	No	No	0	7	6
44	R:R:F48	R:R:L49	3.65	Yes	No	0	6	4
45	R:R:F48	R:R:V52	5.24	Yes	No	0	6	5
46	R:R:C86	R:R:F48	2.79	No	Yes	0	5	6
47	R:R:F48	R:R:L89	7.31	Yes	No	0	6	7
48	R:R:F48	R:R:P90	11.56	Yes	No	0	6	9
49	R:R:C294	R:R:V50	3.42	No	No	0	7	6
50	R:R:C86	R:R:G51	1.96	No	No	0	5	8
51	R:R:F83	R:R:V52	5.24	No	No	0	8	5
52	R:R:D82	R:R:N55	10.77	No	No	0	9	9
53	R:R:F83	R:R:N55	6.04	No	No	0	8	9
54	R:R:A79	R:R:V58	3.39	No	No	0	8	8
55	R:R:A79	R:R:V59	3.39	No	No	0	8	7
56	R:R:S314	R:R:W60	9.88	No	No	0	4	4
57	R:R:L76	R:R:T62	7.37	No	No	0	6	6
58	R:R:E65	R:R:F64	8.16	No	No	4	5	4
59	R:R:F64	R:R:K313	3.72	No	No	4	4	4
60	R:R:F64	R:R:S314	11.89	No	No	0	4	4
61	R:R:E65	R:R:R310	9.3	No	Yes	4	5	4
62	R:R:E65	R:R:K313	4.05	No	No	4	5	4
63	R:R:A72	R:R:T69	3.36	No	No	0	7	7
64	R:R:I70	R:R:R148	3.76	No	No	0	6	7
65	R:R:F75	R:R:N71	2.42	Yes	No	0	8	7
66	R:R:I73	R:R:W154	10.57	No	No	0	6	3
67	R:R:F75	R:R:W74	2	Yes	Yes	2	8	7
68	R:R:T129	R:R:W74	6.06	No	Yes	0	6	7
69	R:R:I130	R:R:W74	2.35	Yes	Yes	2	8	7
70	R:R:D133	R:R:W74	12.28	No	Yes	0	8	7
71	R:R:A153	R:R:W74	5.19	No	Yes	0	7	7
72	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
73	R:R:C157	R:R:W74	3.92	No	Yes	0	6	7
74	R:R:F75	R:R:I130	11.3	Yes	Yes	2	8	8
75	R:R:F75	R:R:R134	5.34	Yes	No	2	8	9
76	R:R:F75	R:R:Y300	11.35	Yes	No	0	8	9
77	R:R:N77	R:R:W154	2.26	No	No	0	9	3
78	R:R:C157	R:R:N77	6.3	No	No	0	6	9
79	R:R:N77	R:R:W161	6.78	No	Yes	0	9	9
80	R:R:L126	R:R:L78	9.69	No	No	0	7	9
81	R:R:L127	R:R:L78	2.77	No	No	0	8	9
82	R:R:I130	R:R:L78	4.28	Yes	No	0	8	9
83	R:R:L84	R:R:V80	2.98	No	No	0	6	5
84	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
85	R:R:C293	R:R:D82	9.34	No	No	0	8	9
86	R:R:F83	R:R:L87	2.44	No	No	0	8	4
87	R:R:L84	R:R:N119	4.12	No	No	0	6	9
88	R:R:N119	R:R:S85	5.96	No	No	0	9	6
89	R:R:M120	R:R:S85	4.6	No	No	1	7	6
90	R:R:S85	R:R:Y290	6.36	No	No	1	6	7
91	R:R:L89	R:R:L92	4.15	No	No	0	7	6
92	R:R:F104	R:R:I91	3.77	Yes	No	0	7	6
93	R:R:H101	R:R:Q98	13.6	No	No	0	4	4
94	R:R:H101	R:R:P103	18.3	No	No	0	4	3
95	R:R:F104	R:R:W102	15.03	Yes	Yes	5	7	8
96	R:R:A108	R:R:W102	2.59	No	Yes	5	5	8
97	R:R:C109	R:R:W102	3.92	Yes	Yes	5	9	8
98	R:R:V186	R:R:W102	3.68	No	Yes	0	6	8
99	R:R:F104	R:R:P103	2.89	Yes	No	0	7	3
100	R:R:A108	R:R:F104	2.77	No	Yes	5	5	7
101	R:R:G105	R:R:G106	2.11	No	No	0	7	3
102	R:R:C109	R:R:G106	1.96	Yes	No	5	9	3
103	R:R:G106	R:R:V177	3.68	No	No	5	3	4
104	R:R:A108	R:R:L112	3.15	No	No	0	5	5
105	R:R:C109	R:R:V177	3.42	Yes	No	5	9	4
106	R:R:C109	R:R:C188	7.28	Yes	No	0	9	9
107	R:R:I111	R:R:S110	3.1	No	No	0	4	6
108	R:R:F172	R:R:I111	7.54	No	No	0	4	4
109	R:R:L112	R:R:P113	3.28	No	No	0	5	6
110	R:R:P113	R:R:R175	8.65	No	Yes	1	6	5
111	R:R:S114	R:R:T168	3.2	No	No	7	5	6
112	R:R:S114	R:R:S171	3.26	No	No	0	5	5
113	R:R:F172	R:R:S114	10.57	No	No	7	4	5
114	R:R:L115	R:R:N119	5.49	No	No	0	5	9
115	R:R:L117	R:R:Y121	2.34	No	No	0	4	7
116	R:R:A164	R:R:L118	3.15	No	No	0	7	5
117	R:R:L118	R:R:L165	6.92	No	No	0	5	4
118	R:R:L118	R:R:T168	11.79	No	No	0	5	6
119	R:R:M120	R:R:W255	4.65	No	Yes	1	7	9
120	R:R:M120	R:R:Y290	7.18	No	No	1	7	7
121	R:R:L167	R:R:Y121	2.34	No	No	0	4	7
122	R:R:A122	R:R:W161	3.89	No	Yes	0	6	9
123	R:R:A122	R:R:A164	1.79	No	No	0	6	7
124	R:R:I124	R:R:P214	3.39	Yes	Yes	0	8	9
125	R:R:F251	R:R:I124	2.51	No	Yes	0	9	8
126	R:R:I124	R:R:W255	9.4	Yes	Yes	0	8	9
127	R:R:L125	R:R:W213	2.28	No	No	0	6	5
128	R:R:L127	R:R:N296	5.49	No	No	0	8	9
129	R:R:A128	R:R:P214	1.87	No	Yes	0	7	9
130	R:R:I130	R:R:R134	6.26	Yes	No	2	8	9
131	R:R:L218	R:R:S131	10.51	No	No	2	8	9
132	R:R:S131	R:R:Y222	10.17	No	Yes	2	9	8
133	R:R:D133	R:R:L137	4.07	No	No	0	8	8
134	R:R:R134	R:R:Y222	4.12	No	Yes	2	9	8
135	R:R:F135	R:R:F139	15	Yes	Yes	8	8	7
136	R:R:C221	R:R:F135	6.98	No	Yes	0	6	8
137	R:R:F135	R:R:F224	5.36	Yes	No	8	8	3
138	R:R:F135	R:R:I225	3.77	Yes	No	0	8	8
139	R:R:C144	R:R:L136	3.17	No	No	0	5	5
140	R:R:L137	R:R:R148	10.93	No	No	0	8	7
141	R:R:F139	R:R:V138	3.93	Yes	No	0	7	8
142	R:R:I225	R:R:V138	7.68	No	No	0	8	8
143	R:R:F139	R:R:F224	2.14	Yes	No	8	7	3
144	R:R:F139	R:R:R228	8.55	Yes	No	0	7	5
145	R:R:C144	R:R:W143	2.61	No	No	0	5	5
146	R:R:F147	R:R:W143	10.02	No	No	0	4	5
147	R:R:N146	R:R:Q145	2.64	No	No	0	5	5
148	R:R:F147	R:R:N146	9.67	No	No	0	4	5
149	R:R:L163	R:R:V159	2.98	No	No	0	4	1
150	R:R:L167	R:R:R206	2.43	No	No	0	4	6
151	R:R:F172	R:R:T168	3.89	No	No	7	4	6
152	R:R:I169	R:R:P170	3.39	No	No	0	3	8
153	R:R:P170	R:R:V202	3.53	No	No	9	8	5
154	R:R:P170	R:R:R206	4.32	No	No	9	8	6
155	R:R:R175	R:R:S171	2.64	Yes	No	0	5	5
156	R:R:L173	R:R:Y174	4.69	No	Yes	0	4	4
157	R:R:Y174	R:R:Y192	9.93	Yes	Yes	0	4	5
158	R:R:D195	R:R:Y174	5.75	No	Yes	10	3	4
159	R:R:R198	R:R:Y174	3.09	No	Yes	10	3	4
160	R:R:C188	R:R:R175	4.18	No	Yes	0	9	5
161	R:R:R175	R:R:V190	2.62	Yes	No	0	5	5
162	R:R:R178	R:R:V176	9.15	No	No	6	2	4
163	R:R:E179	R:R:Y181	5.61	No	No	0	2	1
164	R:R:E179	R:R:V186	5.7	No	No	0	2	6
165	R:R:E180	R:R:F182	9.33	No	No	0	1	3
166	R:R:E180	R:R:K185	8.1	No	No	0	1	3
167	R:R:F182	R:R:P183	2.89	No	No	0	3	4
168	R:R:P183	R:R:P184	1.95	No	No	0	4	5
169	R:R:V190	R:R:Y192	7.57	No	Yes	0	5	5
170	R:R:E199	R:R:Y192	22.45	No	Yes	0	4	5
171	R:R:V202	R:R:Y192	3.79	No	Yes	0	5	5
172	R:R:H194	R:R:S193	13.95	No	No	0	1	4
173	R:R:D195	R:R:R198	7.15	No	No	10	3	3
174	R:R:F267	R:R:R200	6.41	No	No	0	4	3
175	R:R:R206	R:R:V202	9.15	No	No	9	6	5
176	R:R:A203	R:R:S266	3.42	No	No	0	5	5
177	R:R:F267	R:R:I204	6.28	No	No	0	4	3
178	R:R:I263	R:R:L207	9.99	Yes	No	0	5	5
179	R:R:L212	R:R:V208	4.47	No	No	0	4	4
180	R:R:G210	R:R:L209	3.42	No	No	0	6	4
181	R:R:G210	R:R:P214	2.03	No	Yes	0	6	9
182	R:R:F211	R:R:F251	6.43	Yes	No	0	8	9
183	R:R:F211	R:R:F252	3.22	Yes	Yes	1	8	5
184	R:R:F211	R:R:W255	2	Yes	Yes	1	8	9
185	R:R:F211	R:R:L256	2.44	Yes	No	1	8	5
186	R:R:F211	R:R:Q259	3.51	Yes	No	1	8	8
187	R:R:P214	R:R:W213	6.76	Yes	No	0	9	5
188	R:R:T217	R:R:W213	6.06	No	No	0	5	5
189	R:R:F252	R:R:L215	4.87	Yes	No	0	5	5
190	R:R:I220	R:R:L216	4.28	No	No	0	3	2
191	R:R:L218	R:R:Y222	3.52	No	Yes	2	8	8
192	R:R:I220	R:R:T219	3.04	No	No	0	3	4
193	R:R:F224	R:R:I220	3.77	No	No	0	3	3
194	R:R:I225	R:R:Y222	2.42	No	Yes	0	8	8
195	R:R:V244	R:R:Y222	16.4	No	Yes	0	7	8
196	R:R:L226	R:R:W230	2.28	No	No	0	5	4
197	R:R:L226	R:R:T240	2.95	No	No	0	5	7
198	R:R:L226	R:R:L241	4.15	No	No	0	5	6
199	R:R:T229	R:R:W230	2.43	No	No	0	8	4
200	R:R:T229	R:R:T235	3.14	No	No	0	8	4
201	R:R:R236	R:R:W230	8	No	No	0	5	4
202	R:R:K239	R:R:V243	3.04	No	Yes	0	7	7
203	R:R:L241	R:R:V245	2.98	No	No	0	6	4
204	R:R:I295	R:R:S250	3.1	Yes	No	0	7	6
205	R:R:F251	R:R:N292	2.42	No	No	0	9	9
206	R:R:F252	R:R:I253	3.77	Yes	No	0	5	5
207	R:R:F252	R:R:L256	6.09	Yes	No	1	5	5
208	R:R:F254	R:R:I253	2.51	Yes	No	0	8	5
209	R:R:F254	R:R:F288	6.43	Yes	No	3	8	8
210	R:R:F254	R:R:I291	5.02	Yes	Yes	3	8	5
211	R:R:F254	R:R:I295	3.77	Yes	Yes	3	8	7
212	R:R:W255	R:R:Y258	2.89	Yes	Yes	1	9	7
213	R:R:Q259	R:R:W255	5.48	No	Yes	1	8	9
214	R:R:A289	R:R:W255	3.89	No	Yes	1	8	9
215	R:R:N292	R:R:W255	10.17	No	Yes	0	9	9
216	R:R:L256	R:R:P257	3.28	No	No	0	5	9
217	R:R:F288	R:R:P257	7.22	No	No	0	8	9
218	R:R:Q259	R:R:Y258	7.89	No	Yes	1	8	7
219	R:R:V286	R:R:Y258	5.05	Yes	Yes	1	5	7
220	R:R:A289	R:R:Y258	5.34	No	Yes	1	8	7
221	R:R:G262	R:R:T261	3.64	No	No	0	5	4
222	R:R:C285	R:R:T261	6.76	No	No	0	6	4
223	R:R:F267	R:R:I263	7.54	No	Yes	0	4	5
224	R:R:F275	R:R:M265	7.46	Yes	Yes	0	3	4
225	R:R:L278	R:R:M265	2.83	No	Yes	0	4	4
226	R:R:K279	R:R:M265	4.32	No	Yes	0	4	4
227	R:R:L268	R:R:S272	3	No	No	12	2	4
228	R:R:L268	R:R:T274	4.42	No	No	12	2	1
229	R:R:F275	R:R:L268	3.65	Yes	No	0	3	2
230	R:R:F275	R:R:P270	10.11	Yes	No	0	3	3
231	R:R:P273	R:R:S272	3.56	No	No	0	2	4
232	R:R:S272	R:R:T274	4.8	No	No	12	4	1
233	R:R:D282	R:R:K279	9.68	No	No	0	4	4
234	R:R:F288	R:R:I291	3.77	No	Yes	3	8	5
235	R:R:C293	R:R:Y290	8.06	No	No	0	8	7
236	R:R:I291	R:R:I295	2.94	Yes	Yes	3	5	7
237	R:R:I295	R:R:N292	2.83	Yes	No	0	7	9
238	R:R:R310	R:R:Y300	2.06	Yes	No	0	4	9
239	R:R:F307	R:R:V301	7.87	Yes	No	0	9	6
240	R:R:F307	R:R:R310	3.21	Yes	Yes	4	9	4
241	R:R:F307	R:R:L311	2.44	Yes	No	0	9	6
242	R:R:Q308	R:R:R312	7.01	No	No	0	8	5
243	R:R:G309	R:R:R312	3	No	No	0	5	5
244	R:R:L311	R:R:R312	4.86	No	No	0	6	5
245	R:R:P297	R:R:V58	1.77	Yes	No	0	9	8
246	R:R:G262	R:R:M265	1.75	No	Yes	0	5	4
247	R:R:G54	R:R:L53	1.71	No	No	0	7	4
248	R:R:A303	R:R:V243	1.7	No	Yes	0	6	7
249	R:R:I298	R:R:P297	1.69	No	Yes	0	7	9
250	R:R:A72	R:R:T62	1.68	No	No	0	7	6
251	R:R:A160	R:R:T129	1.68	No	No	0	6	6
252	R:R:A132	R:R:T217	1.68	No	No	0	5	5
253	R:R:K140	R:R:P141	1.67	No	No	0	6	8
254	R:R:N55	R:R:P297	1.63	No	Yes	0	9	9
255	R:R:N296	R:R:P297	1.63	No	Yes	0	9	9
256	R:R:A66	R:R:I73	1.62	No	No	0	5	6
257	R:R:A150	R:R:I70	1.62	No	No	0	3	6
258	R:R:A88	R:R:I91	1.62	No	No	0	6	6
259	R:R:A88	R:R:I116	1.62	No	No	0	6	6
260	R:R:A203	R:R:I263	1.62	No	Yes	0	5	5
261	R:R:V42	R:R:V46	1.6	No	No	0	5	4
262	R:R:V46	R:R:V50	1.6	No	No	0	4	6
263	R:R:S237	R:R:T240	1.6	No	No	0	7	7
264	R:R:V243	R:R:V247	1.6	Yes	No	11	7	7
265	R:R:C144	R:R:L137	1.59	No	No	0	5	8
266	R:R:T229	R:R:V138	1.59	No	No	0	8	8
267	R:R:T261	R:R:V260	1.59	No	No	0	4	6
268	R:R:C285	R:R:L281	1.59	No	No	0	6	5
269	R:R:A66	R:R:L76	1.58	No	No	0	5	6
270	R:R:T219	R:R:T223	1.57	No	No	0	4	2
271	R:R:E269	R:R:P270	1.57	No	No	0	3	3
272	R:R:I124	R:R:S123	1.55	Yes	No	0	8	9
273	R:R:I43	R:R:V47	1.54	Yes	No	3	5	6
274	R:R:I291	R:R:V47	1.54	Yes	No	3	5	6
275	R:R:I155	R:R:V159	1.54	No	No	0	2	1
276	R:R:I204	R:R:V208	1.54	No	No	0	3	4
277	R:R:I299	R:R:V243	1.54	No	Yes	11	7	7
278	R:R:I299	R:R:V247	1.54	No	No	11	7	7
279	R:R:I298	R:R:V302	1.54	No	No	0	7	6
280	L:L:P3	R:R:H100	1.53	No	No	0	0	4
281	R:R:K239	R:R:S237	1.53	No	No	0	7	7
282	R:R:K242	R:R:T238	1.5	No	No	0	6	5
283	R:R:G304	R:R:R310	1.5	No	Yes	0	8	4
284	R:R:L41	R:R:V97	1.49	No	No	0	5	3
285	R:R:L167	R:R:V205	1.49	No	No	0	4	3
286	R:R:L227	R:R:T223	1.47	No	No	0	4	2
287	R:R:I263	R:R:M264	1.46	Yes	No	0	5	4
288	R:R:E199	R:R:S266	1.44	No	No	0	4	5
289	R:R:E269	R:R:S271	1.44	No	No	0	3	4
290	R:R:I96	R:R:L41	1.43	No	No	0	5	5
291	R:R:Q98	R:R:V97	1.43	No	No	0	4	3
292	R:R:G151	R:R:W154	1.41	No	No	0	4	3
293	R:R:G162	R:R:W161	1.41	No	Yes	0	4	9
294	R:R:L125	R:R:L163	1.38	No	No	0	6	4
295	R:R:L277	R:R:L281	1.38	No	No	0	1	5
296	R:R:H101	R:R:T94	1.37	No	No	0	4	3
297	R:R:F307	R:R:V61	1.31	Yes	No	4	9	6
298	R:R:R310	R:R:V61	1.31	Yes	No	4	4	6
299	R:R:H99	R:R:K185	1.31	No	No	0	2	3
300	R:R:R68	R:R:T69	1.29	No	No	0	7	7
301	R:R:R232	R:R:T235	1.29	No	No	0	5	4
302	R:R:Q305	R:R:R310	1.17	No	Yes	0	6	4
303	R:R:R197	R:R:R198	1.07	No	No	0	1	3
304	R:R:R233	R:R:R236	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.44875	8	6	0
2	L:L:?4	8.582	5	1	0
3	L:L:?5	11.8733	6	1	0
4	L:L:?6	10.975	6	1	0
5	R:R:I43	4.1375	4	3	5
6	R:R:F44	5.60667	6	1	7
7	R:R:F48	6.11	5	0	6
8	R:R:W74	4.91286	7	2	7
9	R:R:F75	6.482	5	2	8
10	R:R:W102	6.305	4	5	8
11	R:R:F104	6.115	4	5	7
12	R:R:C109	4.145	4	5	9
13	R:R:I124	4.2125	4	0	8
14	R:R:I130	6.0475	4	2	8
15	R:R:F135	7.7775	4	8	8
16	R:R:F139	7.405	4	8	7
17	R:R:W161	3.6675	4	0	9
18	R:R:Y174	5.865	4	10	4
19	R:R:R175	4.76	5	1	5
20	R:R:Y192	10.935	4	0	5
21	R:R:F211	3.52	5	1	8
22	R:R:P214	3.5125	4	0	9
23	R:R:Y222	7.326	5	2	8
24	R:R:V243	1.97	4	11	7
25	R:R:F252	4.4875	4	1	5
26	R:R:F254	4.4325	4	3	8
27	R:R:W255	5.49714	7	1	9
28	R:R:Y258	7.414	5	1	7
29	R:R:I263	5.1525	4	0	5
30	R:R:M265	4.09	4	0	4
31	R:R:F275	7.4775	4	0	3
32	R:R:V286	3.465	4	1	5
33	R:R:I291	3.538	5	3	5
34	R:R:I295	3.16	4	3	7
35	R:R:P297	1.68	4	0	9
36	R:R:F307	3.7075	4	4	9
37	R:R:R310	3.09167	6	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:K2	24.5534	6.1	Yes	No	0	0	0
2	L:L:K2	R:R:E199	37.3354	6.75	No	No	0	0	4
3	L:L:K2	R:R:F275	12.1628	8.69	No	Yes	0	0	3
4	R:R:F275	R:R:P270	11.6291	10.11	Yes	No	0	3	3
5	R:R:E199	R:R:Y192	61.9315	22.45	No	Yes	0	4	5
6	R:R:V190	R:R:Y192	81.7664	7.57	No	Yes	0	5	5
7	L:L:?6	R:R:V190	56.0245	3.57	Yes	No	0	0	5
8	L:L:?4	L:L:?6	42.0539	2.08	Yes	Yes	1	0	0
9	R:R:R175	R:R:V190	71.7458	2.62	Yes	No	0	5	5
10	L:L:?4	R:R:R175	43.3065	5.71	Yes	Yes	1	0	5
11	L:L:?5	L:L:?6	19.657	31.09	Yes	Yes	1	0	0
12	L:L:?4	R:R:L92	30.6953	6.5	Yes	No	1	0	6
13	L:L:?5	R:R:L92	20.8953	2.36	Yes	No	1	0	6
14	L:L:?5	R:R:I116	10.2697	6.09	Yes	No	0	0	6
15	L:L:?6	R:R:V286	34.4673	2.38	Yes	Yes	1	0	5
16	L:L:?6	R:R:Y258	58.1951	15.9	Yes	Yes	1	0	7
17	R:R:F275	R:R:M265	21.0376	7.46	Yes	Yes	0	3	4
18	R:R:K279	R:R:M265	48.5375	4.32	No	Yes	0	4	4
19	R:R:D282	R:R:K279	52.0675	9.68	No	No	0	4	4
20	R:R:F44	R:R:V286	49.3773	2.62	Yes	Yes	1	7	5
21	R:R:A40	R:R:F44	18.7246	2.77	No	Yes	1	6	7
22	R:R:A40	R:R:L284	16.1341	3.15	No	No	0	6	4
23	R:R:L284	R:R:P36	13.4795	3.28	No	No	0	4	3
24	R:R:F44	R:R:S287	24.8025	14.53	Yes	No	0	7	4
25	R:R:I43	R:R:S287	22.3899	7.74	Yes	No	0	5	4
26	R:R:F44	R:R:I96	13.7214	3.77	Yes	No	0	7	5
27	R:R:I96	R:R:L41	11.5081	1.43	No	No	0	5	5
28	R:R:W255	R:R:Y258	56.3376	2.89	Yes	Yes	1	9	7
29	R:R:N292	R:R:W255	15.7569	10.17	No	Yes	0	9	9
30	R:R:I295	R:R:N292	13.3015	2.83	Yes	No	0	7	9
31	R:R:L89	R:R:L92	50.2954	4.15	No	No	0	7	6
32	R:R:F44	R:R:L89	39.8975	7.31	Yes	No	0	7	7
33	R:R:I43	R:R:V47	11.8782	1.54	Yes	No	3	5	6
34	R:R:C294	R:R:V47	11.0953	5.12	No	No	0	7	6
35	R:R:F48	R:R:L89	75.5106	7.31	Yes	No	0	6	7
36	R:R:F48	R:R:V52	68.714	5.24	Yes	No	0	6	5
37	R:R:F83	R:R:V52	67.4045	5.24	No	No	0	8	5
38	R:R:M120	R:R:W255	42.2817	4.65	No	Yes	1	7	9
39	R:R:M120	R:R:Y290	34.695	7.18	No	No	1	7	7
40	R:R:C293	R:R:Y290	37.8692	8.06	No	No	0	8	7
41	R:R:C293	R:R:D82	37.2998	9.34	No	No	0	8	9
42	R:R:F83	R:R:N55	65.5541	6.04	No	No	0	8	9
43	R:R:D82	R:R:N55	37.2927	10.77	No	No	0	9	9
44	R:R:N55	R:R:P297	98.4272	1.63	No	Yes	0	9	9
45	R:R:R175	R:R:S171	100	2.64	Yes	No	0	5	5
46	R:R:S114	R:R:S171	98.6691	3.26	No	No	0	5	5
47	R:R:S114	R:R:T168	90.5487	3.2	No	No	7	5	6
48	R:R:L118	R:R:T168	91.9081	11.79	No	No	0	5	6
49	R:R:A164	R:R:L118	89.289	3.15	No	No	0	7	5
50	R:R:A122	R:R:A164	88.0009	1.79	No	No	0	6	7
51	R:R:A122	R:R:W161	86.7483	3.89	No	Yes	0	6	9
52	R:R:N77	R:R:W161	83.1186	6.78	No	Yes	0	9	9
53	R:R:C157	R:R:N77	71.8312	6.3	No	No	0	6	9
54	R:R:C157	R:R:W74	72.244	3.92	No	Yes	0	6	7
55	R:R:F75	R:R:W74	39.7765	2	Yes	Yes	2	8	7
56	R:R:F75	R:R:Y300	34.325	11.35	Yes	No	0	8	9
57	R:R:R310	R:R:Y300	32.3749	2.06	Yes	No	0	4	9
58	R:R:E65	R:R:R310	11.017	9.3	No	Yes	4	5	4
59	R:R:N77	R:R:W154	27.3717	2.26	No	No	0	9	3
60	R:R:I73	R:R:W154	21.4647	10.57	No	No	0	6	3
61	R:R:A66	R:R:I73	18.44	1.62	No	No	0	5	6
62	R:R:A66	R:R:L76	15.401	1.58	No	No	0	5	6
63	R:R:L76	R:R:T62	12.3479	7.37	No	No	0	6	6
64	R:R:D133	R:R:W74	24.3541	12.28	No	Yes	0	8	7
65	R:R:D133	R:R:L137	22.2973	4.07	No	No	0	8	8
66	R:R:I130	R:R:W74	39.7836	2.35	Yes	Yes	2	8	7
67	R:R:F75	R:R:R134	28.7239	5.34	Yes	No	2	8	9
68	R:R:I130	R:R:R134	70.237	6.26	Yes	No	2	8	9
69	R:R:N296	R:R:P297	87.5383	1.63	No	Yes	0	9	9
70	R:R:L127	R:R:N296	85.7092	5.49	No	No	0	8	9
71	R:R:L127	R:R:L78	83.9015	2.77	No	No	0	8	9
72	R:R:L112	R:R:P113	15.7071	3.28	No	No	0	5	6
73	R:R:A108	R:R:L112	13.1592	3.15	No	No	0	5	5
74	R:R:C188	R:R:R175	29.9338	4.18	No	Yes	0	9	5
75	R:R:C109	R:R:C188	27.0586	7.28	Yes	No	0	9	9
76	R:R:C109	R:R:W102	15.7996	3.92	Yes	Yes	5	9	8
77	R:R:V186	R:R:W102	12.5899	3.68	No	Yes	0	6	8
78	R:R:V202	R:R:Y192	11.4298	3.79	No	Yes	0	5	5
79	R:R:I124	R:R:W255	28.9232	9.4	Yes	Yes	0	8	9
80	R:R:I124	R:R:P214	24.7313	3.39	Yes	Yes	0	8	9
81	R:R:F211	R:R:W255	15.3939	2	Yes	Yes	1	8	9
82	R:R:Q259	R:R:Y258	10.5259	7.89	No	Yes	1	8	7
83	R:R:P214	R:R:W213	15.9348	6.76	Yes	No	0	9	5
84	R:R:R134	R:R:Y222	96.5198	4.12	No	Yes	2	9	8
85	R:R:I225	R:R:Y222	86.2999	2.42	No	Yes	0	8	8
86	R:R:F135	R:R:I225	29.2719	3.77	Yes	No	0	8	8
87	R:R:I225	R:R:V138	54.8004	7.68	No	No	0	8	8
88	R:R:F135	R:R:F224	17.5005	5.36	Yes	No	8	8	3
89	R:R:C144	R:R:L137	13.6574	1.59	No	No	0	5	8
90	R:R:Y174	R:R:Y192	13.4439	9.93	Yes	Yes	0	4	5
91	R:R:E199	R:R:S266	26.539	1.44	No	No	0	4	5
92	R:R:A203	R:R:S266	23.9485	3.42	No	No	0	5	5
93	R:R:A203	R:R:I263	21.3437	1.62	No	Yes	0	5	5
94	R:R:F267	R:R:I263	13.4439	7.54	No	Yes	0	4	5
95	R:R:F224	R:R:I220	15.2943	3.77	No	No	0	3	3
96	R:R:T229	R:R:V138	47.3062	1.59	No	No	0	8	8
97	R:R:T229	R:R:W230	38.6165	2.43	No	No	0	8	4
98	R:R:L226	R:R:W230	29.7772	2.28	No	No	0	5	4
99	R:R:L226	R:R:T240	20.9949	2.95	No	No	0	5	7
100	R:R:S237	R:R:T240	18.1909	1.6	No	No	0	7	7
101	R:R:K239	R:R:S237	15.1591	1.53	No	No	0	7	7
102	R:R:K239	R:R:V243	12.113	3.04	No	Yes	0	7	7
103	R:R:G262	R:R:M265	24.8025	1.75	No	Yes	0	5	4
104	R:R:G262	R:R:T261	20.7032	3.64	No	No	0	5	4
105	R:R:C285	R:R:T261	12.4617	6.76	No	No	0	6	4
106	R:R:F275	R:R:L268	14.7961	3.65	Yes	No	0	3	2
107	R:R:F307	R:R:R310	13.3585	3.21	Yes	Yes	4	9	4
108	L:L:?6	R:R:D282	55.4267	10.83	Yes	No	0	0	4
109	L:L:?4	R:R:P113	10.4832	3.09	Yes	No	1	0	6
110	R:R:I130	R:R:L78	80.2149	4.28	Yes	No	0	8	9
111	L:L:?5	R:R:V286	12.5614	3.81	Yes	Yes	1	0	5
112	R:R:F75	R:R:I130	18.504	11.3	Yes	Yes	2	8	8
113	R:R:V286	R:R:Y258	10.2982	5.05	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V176	2.58	6	Yes	No	0	4	0	1
L:L:?1	R:R:R178	18.92	6	Yes	No	0	2	0	1
L:L:?1	R:R:L187	10.78	6	Yes	No	0	4	0	1
L:L:?1	R:R:G189	5.92	6	Yes	No	0	4	0	1
L:L:?1	R:R:D191	17.61	6	Yes	No	0	4	0	1
L:L:?1	R:R:P270	2.84	6	Yes	No	0	3	0	1
L:L:K2	R:R:E199	6.75	0	No	No	0	4	0	1
L:L:K2	R:R:F275	8.69	0	No	Yes	0	3	0	1
L:L:P3	R:R:L187	9.85	6	No	No	0	4	0	1
L:L:?4	R:R:L92	6.5	1	Yes	No	0	6	0	1
L:L:?4	R:R:P113	3.09	1	Yes	No	0	6	0	1
L:L:?4	R:R:R175	5.71	1	Yes	Yes	0	5	0	1
L:L:?5	R:R:L92	2.36	1	Yes	No	0	6	0	1
L:L:?5	R:R:I116	6.09	1	Yes	No	0	6	0	1
L:L:?5	R:R:L117	2.36	1	Yes	No	0	4	0	1
L:L:?5	R:R:V286	3.81	1	Yes	Yes	0	5	0	1
L:L:?6	R:R:V190	3.57	1	Yes	No	0	5	0	1
L:L:?6	R:R:Y258	15.9	1	Yes	Yes	0	7	0	1
L:L:?6	R:R:D282	10.83	1	Yes	No	0	4	0	1
L:L:?6	R:R:V286	2.38	1	Yes	Yes	0	5	0	1
R:R:F44	R:R:L89	7.31	1	Yes	No	7	7	2	2
R:R:F44	R:R:V286	2.62	1	Yes	Yes	7	5	2	1
R:R:L89	R:R:L92	4.15	0	No	No	7	6	2	1
R:R:L112	R:R:P113	3.28	0	No	No	5	6	2	1
R:R:P113	R:R:R175	8.65	1	No	Yes	6	5	1	1
R:R:L117	R:R:Y121	2.34	0	No	No	4	7	1	2
R:R:R175	R:R:S171	2.64	1	Yes	No	5	5	1	2
R:R:C188	R:R:R175	4.18	0	No	Yes	9	5	2	1
R:R:R175	R:R:V190	2.62	1	Yes	No	5	5	1	1
R:R:R178	R:R:V176	9.15	6	No	No	2	4	1	1
R:R:V190	R:R:Y192	7.57	0	No	Yes	5	5	1	2
R:R:E199	R:R:Y192	22.45	0	No	Yes	4	5	1	2
R:R:W255	R:R:Y258	2.89	1	Yes	Yes	9	7	2	1
R:R:Q259	R:R:W255	5.48	1	No	Yes	8	9	2	2
R:R:A289	R:R:W255	3.89	1	No	Yes	8	9	2	2
R:R:Q259	R:R:Y258	7.89	1	No	Yes	8	7	2	1
R:R:V286	R:R:Y258	5.05	1	Yes	Yes	5	7	1	1
R:R:A289	R:R:Y258	5.34	1	No	Yes	8	7	2	1
R:R:F275	R:R:M265	7.46	0	Yes	Yes	3	4	1	2
R:R:K279	R:R:M265	4.32	0	No	Yes	4	4	2	2
R:R:F275	R:R:L268	3.65	0	Yes	No	3	2	1	2
R:R:F275	R:R:P270	10.11	0	Yes	No	3	3	1	1
R:R:D282	R:R:K279	9.68	0	No	No	4	4	1	2
R:R:A88	R:R:I116	1.62	0	No	No	6	6	2	1
R:R:E269	R:R:P270	1.57	0	No	No	3	3	2	1
L:L:P3	R:R:H100	1.53	6	No	No	0	4	0	1
R:R:E199	R:R:S266	1.44	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y65_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.79
Number of Linked Nodes	265
Number of Links	304
Number of Hubs	37
Number of Links mediated by Hubs	147
Number of Communities	12
Number of Nodes involved in Communities	68
Number of Links involved in Communities	85

Path Summary
Number Of Nodes in MetaPath	114
Number Of Links MetaPath	113
Number of Shortest Paths	51694
Length Of Smallest Path	3
Average Path Length	14.6928
Length of Longest Path	34
Minimum Path Strength	1.24
Average Path Strength	5.4025
Maximum Path Strength	23.495
Minimum Path Correlation	0.7
Average Path Correlation	0.931992
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	52.3136
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.9638
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response • immune system process • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of immune response • activation of immune response • amyloid-beta clearance • cell chemotaxis • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • taxis • granulocyte chemotaxis • response to chemical • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • system process • nervous system process • cognition • cell population proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • macrophage migration • regulation of mononuclear cell migration • positive regulation of macrophage migration • macrophage chemotaxis • regulation of macrophage migration • positive regulation of mononuclear cell migration • regulation of macrophage chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • response to stress • anatomical structure development • system development • developmental process • defense response • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • complement component C5a signaling pathway • G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular defense response • sensory perception of chemical stimulus • sensory perception • biological process involved in interspecies interaction between organisms • response to other organism • response to oxygen-containing compound • response to nitrogen compound • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • cellular anatomical structure • apical part of cell • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• cellular anatomical structure • apical part of cell • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MEA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	MEA
Name	N-METHYLPHENYLALANINE
Synonyms
Identifier
Formula	C10 H13 N O2
Molecular Weight	179.216
SMILES
PubChem	6951135
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	ZAL
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	ZAL
Name	3-cyclohexyl-D-alanine
Synonyms
Identifier
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES
PubChem	736026
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0


Code	ALC
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	ALC
Name	3-Cyclohexyl-L-alanine
Synonyms	3-Cyclohexyl-L-alanine beta-Cyclohexyl-alanine beta-Cyclohexyl-L-alanine β-Cyclohexyl-alanine
Identifier
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES
PubChem	712421
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0


Code	DAR
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	DAR
Name	D-arginine
Synonyms	(2R)-2-amino-5-guanidinopentanoic acid
Identifier
Formula	C6 H15 N4 O2
Molecular Weight	175.209
SMILES
PubChem	17753939
Formal Charge	1
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>7Y65_nogp_Chain_R T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E Y F P P K V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S L P S L L R N V L T E E S V V R E S K S F T R S T V D T M A Q K T Q A V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KWG	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWX	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.13	2025-11-26	10.1101/2025.05.26.656101
	9KWX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.13	2025-11-26	10.1101/2025.05.26.656101
	9KX6	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.11	2025-11-26	10.1101/2025.05.26.656101
	9KX6 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.11	2025-11-26	10.1101/2025.05.26.656101
	9KXS	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-	Go/β1/γ2	3.31	2025-11-26	10.1101/2025.05.26.656101
	9KXS (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-		3.31	2025-11-26	10.1101/2025.05.26.656101
	9UMR	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMR (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMX	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-	Go/β1/γ2	3.2	2025-11-26	10.1101/2025.05.26.656101
	9UMX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-		3.2	2025-11-26	10.1101/2025.05.26.656101
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.54	2025-01-15	To be published
	9KUG	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-	Go/β1/γ2	3.07	2025-11-26	10.1101/2025.05.26.656101
	9KUG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-		3.07	2025-11-26	10.1101/2025.05.26.656101

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.