Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y694 4.98571725
2L:L:H696 4.865424
3L:L:V698 3.966521
4L:L:P699 4.27421
5L:L:R708 14.105421
6L:L:C728 5.8575428
7L:L:F732 5.845628
8L:L:Q752 4.78404
9L:L:L753 3.6225418
10R:R:D26 5.4075403
11R:R:P35 4.72667644
12R:R:Y44 5.078518
13R:R:I73 7.445476
14R:R:W74 7.18833687
15R:R:L89 5.968518
16R:R:L92 4.025416
17R:R:Y101 11.84525
18R:R:W102 9.5325419
19R:R:L126 3.1275408
20R:R:I130 4.395409
21R:R:F135 8.1225438
22R:R:F139 10.8875438
23R:R:R148 6.792587
24R:R:W161 4.676509
25R:R:T168 4.9875417
26R:R:S171 4.5675415
27R:R:Y174 8.41754104
28R:R:R175 5.51614
29R:R:Y182 11.53523
30R:R:H185 9.485421
31R:R:Y192 7.9565106
32R:R:K201 9.9225404
33R:R:F212 6.4125408
34R:R:P215 2.74408
35R:R:Y223 9.28409
36R:R:T230 3.43538
37R:R:V245 5.445407
38R:R:F252 5.31667669
39R:R:W256 8.09167668
40R:R:T262 3.555415
41R:R:L269 4.375401
42R:R:L276 4.6025401
43R:R:L285 2.9225416
44R:R:S288 5.5175415
45R:R:Y291 6.66167617
46R:R:Y301 7.5575409
47R:R:F308 6.77833658
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:I687 R:R:F181 11.3210.05NoNo071
2R:R:D180 R:R:F181 15.448516.72NoNo011
3L:L:R743 R:R:D180 16.80371.19NoNo061
4L:L:R743 L:L:V709 18.121211.77NoNo064
5L:L:V709 R:R:Y182 19.472212.62NoYes043
6L:L:R708 R:R:Y182 49.92038.23YesYes213
7L:L:F732 L:L:R708 40.03528.55YesYes281
8L:L:C728 L:L:F732 22.67354.19YesYes288
9L:L:C728 L:L:V698 20.38681.71YesYes281
10L:L:P699 L:L:V698 13.67373.53YesYes211
11L:L:P699 L:L:Y694 12.4574.17YesYes215
12L:L:R718 R:R:D26 18.41497.15NoYes083
13L:L:R708 L:L:R718 10.984328.79YesNo218
14L:L:N710 R:R:Y182 11.15635.81NoYes273
15R:R:H185 R:R:Y182 75.27914.16YesYes213
16R:R:H185 R:R:Y101 88.66747.62YesYes215
17R:R:T186 R:R:Y101 90.664613.73NoYes255
18R:R:A177 R:R:T186 92.52751.68NoNo045
19R:R:A177 R:R:C109 93.27433.61NoNo049
20R:R:C109 R:R:W102 72.00225.22NoYes199
21L:L:L753 R:R:W102 74.93083.42YesYes189
22L:L:L753 R:R:L92 1004.15YesYes186
23R:R:L92 R:R:Y291 99.21124.69YesYes167
24R:R:Y291 R:R:Y44 62.79262.98YesYes178
25R:R:S288 R:R:Y44 52.76926.36YesYes158
26R:R:L285 R:R:S288 38.96953YesYes165
27R:R:L282 R:R:L285 37.55142.77NoYes156
28R:R:L282 R:R:T262 33.62842.95NoYes155
29R:R:N283 R:R:T262 31.32082.92NoYes045
30R:R:I266 R:R:N283 30.04954.25NoNo044
31R:R:I266 R:R:V279 27.48184.61NoNo044
32R:R:L276 R:R:V279 16.54785.96YesNo014
33R:R:C109 R:R:C188 22.00647.28NoNo199
34R:R:C188 R:R:R175 23.38262.79NoYes194
35R:R:G189 R:R:R175 14.05141.5NoYes024
36L:L:H748 R:R:G189 12.68364.77NoNo052
37R:R:I190 R:R:R175 21.460912.53NoYes044
38R:R:V96 R:R:Y44 11.40816.31NoYes058
39R:R:H185 R:R:K32 16.77022.62YesNo014
40R:R:H99 R:R:K32 15.456914.41NoNo044
41R:R:H99 R:R:Q34 14.09339.89NoNo044
42R:R:P35 R:R:Q34 12.71711.58YesNo044
43R:R:I43 R:R:S288 11.90749.29NoYes055
44R:R:M120 R:R:Y291 98.54838.38NoYes087
45R:R:M120 R:R:W256 98.2846.98NoYes088
46R:R:N293 R:R:W256 35.642410.17NoYes698
47R:R:N293 R:R:N297 44.31910.9NoNo099
48R:R:D82 R:R:N297 43.11496.73NoNo099
49R:R:D82 R:R:N55 33.29713.46NoNo099
50R:R:N55 R:R:P298 28.950211.4NoNo099
51R:R:P298 R:R:V58 28.01463.53NoNo099
52R:R:V58 R:R:Y301 27.13773.79NoYes099
53R:R:F308 R:R:Y301 26.98673.09YesYes089
54R:R:F308 R:R:L312 16.384210.96YesNo586
55R:R:L312 R:R:L57 14.69752.77NoNo066
56R:R:G54 R:R:L57 12.88915.13NoNo086
57R:R:G54 R:R:P53 11.07242.03NoNo084
58R:R:C294 R:R:D82 12.98579.34NoNo099
59R:R:C294 R:R:S85 11.39133.44NoNo097
60R:R:F252 R:R:W256 61.32428.02YesYes698
61R:R:F252 R:R:L219 76.78536.09YesNo098
62R:R:L219 R:R:S131 76.17696.01NoNo089
63R:R:S131 R:R:Y223 58.680911.45NoYes099
64R:R:R134 R:R:Y223 49.87839.26NoYes099
65R:R:I130 R:R:R134 49.02246.26YesNo099
66R:R:I130 R:R:W74 28.69854.7YesYes097
67R:R:A153 R:R:W74 16.04853.89NoYes087
68R:R:A153 R:R:I73 14.78564.87NoYes086
69R:R:F75 R:R:I130 13.90453.77NoYes089
70R:R:I130 R:R:L78 17.21912.85YesNo099
71R:R:L126 R:R:L78 14.73112.77YesNo089
72R:R:R175 R:R:S171 13.23743.95YesYes145
73R:R:L117 R:R:Y121 12.25988.21NoNo047
74R:R:R207 R:R:Y121 16.75345.14NoNo057
75R:R:I190 R:R:Y192 17.82338.46NoYes046
76R:R:V203 R:R:Y192 13.93393.79NoYes056
77R:R:R207 R:R:V203 15.74227.85NoNo055
78R:R:G211 R:R:Y121 27.32232.9NoNo067
79R:R:I124 R:R:W256 10.816511.74NoYes688
80R:R:G211 R:R:P215 29.99084.06NoYes068
81R:R:C222 R:R:S131 24.7213.44NoNo089
82R:R:C222 R:R:F135 23.48334.19NoYes088
83R:R:F135 R:R:F139 11.982920.36YesYes388
84R:R:E200 R:R:Y192 14.63047.86NoYes056
85R:R:E200 R:R:K201 12.83044.05NoYes054
86R:R:V245 R:R:Y223 13.803812.62YesYes079
87L:L:L753 R:R:R175 23.67633.64YesYes184
88R:R:I124 R:R:P215 31.70263.39NoYes088
89R:R:F75 R:R:Y301 12.834619.6NoYes089
90R:R:F252 R:R:N293 10.02354.83YesNo699
91R:R:F252 R:R:I124 22.15745.02YesNo698
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:I687 R:R:F181 10.05 0 No No 7 1 0 1
L:L:D705 R:R:D26 3.99 0 No Yes 3 3 0 1
L:L:A707 R:R:F181 6.93 0 No No 6 1 0 1
L:L:R708 R:R:Y182 8.23 2 Yes Yes 1 3 0 1
L:L:V709 R:R:Y182 12.62 0 No Yes 4 3 0 1
L:L:N710 R:R:Y182 5.81 2 No Yes 7 3 0 1
L:L:F711 R:R:E280 7 0 No No 3 3 0 1
L:L:R718 R:R:D26 7.15 2 No Yes 8 3 0 1
L:L:T723 R:R:G27 3.64 0 No No 2 5 0 1
L:L:P747 R:R:G193 4.06 0 No No 3 4 0 1
L:L:H748 R:R:G189 4.77 0 No No 5 2 0 1
L:L:H748 R:R:N191 3.83 0 No No 5 5 0 1
L:L:P750 R:R:V187 3.53 0 No No 1 1 0 1
L:L:V751 R:R:I190 3.07 0 No No 3 4 0 1
L:L:Q752 R:R:T95 4.25 0 Yes No 4 5 0 1
L:L:Q752 R:R:V96 2.87 0 Yes No 4 5 0 1
L:L:Q752 R:R:N100 10.56 0 Yes No 4 3 0 1
L:L:L753 R:R:L92 4.15 1 Yes Yes 8 6 0 1
L:L:L753 R:R:W102 3.42 1 Yes Yes 8 9 0 1
L:L:L753 R:R:P113 3.28 1 Yes No 8 5 0 1
L:L:L753 R:R:R175 3.64 1 Yes Yes 8 4 0 1
R:R:D26 R:R:G27 6.71 0 Yes No 3 5 1 1
R:R:D26 R:R:H29 3.78 0 Yes No 3 3 1 2
R:R:L41 R:R:V96 2.98 0 No No 4 5 2 1
R:R:V96 R:R:Y44 6.31 0 No Yes 5 8 1 2
R:R:V287 R:R:Y44 5.05 0 No Yes 5 8 1 2
R:R:Y291 R:R:Y44 2.98 1 Yes Yes 7 8 2 2
R:R:L92 R:R:V91 2.98 1 Yes No 6 6 1 2
R:R:I116 R:R:L92 4.28 1 No Yes 6 6 2 1
R:R:L92 R:R:Y291 4.69 1 Yes Yes 6 7 1 2
R:R:F104 R:R:W102 19.04 0 No Yes 8 9 2 1
R:R:C109 R:R:W102 5.22 1 No Yes 9 9 2 1
R:R:C188 R:R:W102 10.45 1 No Yes 9 9 2 1
R:R:C109 R:R:C188 7.28 1 No No 9 9 2 2
R:R:P113 R:R:R175 8.65 1 No Yes 5 4 1 1
R:R:I116 R:R:Y291 3.63 1 No Yes 6 7 2 2
R:R:R175 R:R:S171 3.95 1 Yes Yes 4 5 1 2
R:R:C188 R:R:R175 2.79 1 No Yes 9 4 2 1
R:R:I190 R:R:R175 12.53 0 No Yes 4 4 1 1
R:R:E176 R:R:N191 14.46 0 No No 3 5 2 1
R:R:D180 R:R:F181 16.72 0 No No 1 1 1 1
R:R:E184 R:R:Y182 16.83 2 No Yes 5 3 2 1
R:R:H185 R:R:Y182 14.16 2 Yes Yes 1 3 2 1
R:R:E184 R:R:H185 13.54 2 No Yes 5 1 2 2
R:R:I190 R:R:Y192 8.46 0 No Yes 4 6 1 2
R:R:E280 R:R:L276 5.3 0 No Yes 3 1 1 2
L:L:H748 R:R:Y178 2.18 0 No No 5 1 0 1
R:R:G193 R:R:G194 2.11 0 No No 4 1 1 2
L:L:G754 R:R:V287 1.84 0 No No 6 5 0 1
R:R:G193 R:R:N191 1.7 0 No No 4 5 1 1
R:R:L112 R:R:P113 1.64 0 No No 5 5 2 1
L:L:T723 R:R:I28 1.52 0 No No 2 4 0 1
R:R:G189 R:R:R175 1.5 0 No Yes 2 4 1 1
L:L:Q752 R:R:S284 1.44 0 Yes No 4 4 0 1
L:L:R743 R:R:D180 1.19 0 No No 6 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9KWX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.77
Number of Linked Nodes 336
Number of Links 375
Number of Hubs 47
Number of Links mediated by Hubs 185
Number of Communities 10
Number of Nodes involved in Communities 74
Number of Links involved in Communities 97
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 61217
Length Of Smallest Path 3
Average Path Length 15.7429
Length of Longest Path 40
Minimum Path Strength 1.46
Average Path Strength 6.21962
Maximum Path Strength 22.255
Minimum Path Correlation 0.7
Average Path Correlation 0.953595
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 61.3061
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.6961
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• enzyme regulator activity   • molecular function inhibitor activity   • peptidase regulator activity   • molecular function regulator activity   • enzyme inhibitor activity   • peptidase inhibitor activity   • endopeptidase regulator activity   • endopeptidase inhibitor activity   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • C5a anaphylatoxin chemotactic receptor binding   • molecular function activator activity   • signaling receptor activator activity   • cytokine receptor binding   • chemokine activity   • cytokine activity   • signaling receptor regulator activity   • chemokine receptor binding   • receptor ligand activity   • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains   • lymphocyte mediated immunity   • humoral immune response   • response to stimulus   • positive regulation of biological process   • positive regulation of response to stimulus   • complement activation   • humoral immune response mediated by circulating immunoglobulin   • positive regulation of immune response   • leukocyte mediated immunity   • regulation of immune system process   • positive regulation of immune system process   • complement activation, classical pathway   • regulation of biological process
Gene OntologyBiological Process• adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains   • lymphocyte mediated immunity   • humoral immune response   • response to stimulus   • positive regulation of biological process   • positive regulation of response to stimulus   • complement activation   • humoral immune response mediated by circulating immunoglobulin   • positive regulation of immune response   • leukocyte mediated immunity   • regulation of immune system process   • positive regulation of immune system process   • complement activation, classical pathway   • regulation of biological process   • immune response   • biological regulation   • immunoglobulin mediated immune response   • adaptive immune response   • immune effector process   • regulation of response to stimulus   • immune system process   • B cell mediated immunity   • regulation of immune response   • activation of immune response   • cellular response to stimulus   • negative regulation of mononuclear cell migration   • negative regulation of locomotion   • regulation of cell motility   • regulation of cellular process   • negative regulation of biological process   • negative regulation of chemotaxis   • macrophage migration   • taxis   • negative regulation of macrophage chemotaxis   • cell migration   • regulation of mononuclear cell migration   • negative regulation of macrophage migration   • negative regulation of cell migration   • chemotaxis   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • response to external stimulus   • leukocyte migration   • negative regulation of leukocyte migration   • regulation of locomotion   • response to chemical   • negative regulation of response to external stimulus   • negative regulation of cell motility   • negative regulation of leukocyte chemotaxis   • regulation of response to external stimulus   • macrophage chemotaxis   • regulation of macrophage migration   • negative regulation of cellular process   • regulation of cell migration   • myeloid leukocyte migration   • cell motility   • locomotion   • cell chemotaxis   • regulation of macrophage chemotaxis   • negative regulation of response to stimulus   • regulation of chemotaxis   • cellular response to chemical stimulus   • negative regulation of immune system process   • mononuclear cell migration   • cellular process   • leukocyte chemotaxis   • positive regulation of locomotion   • positive regulation of chemotaxis   • positive regulation of response to external stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • defense response   • response to stress   • inflammatory response   • leukocyte migration involved in inflammatory response   • monoamine transport   • regulation of localization   • nitrogen compound transport   • negative regulation of amine transport   • regulation of catecholamine secretion   • transport   • signaling   • negative regulation of transport   • organic hydroxy compound transport   • dopamine transport   • cell communication   • localization   • secretion by cell   • regulation of secretion by cell   • negative regulation of secretion   • catecholamine transport   • negative regulation of dopamine secretion   • signal release   • negative regulation of secretion by cell   • secretion   • regulation of transport   • export from cell   • cell-cell signaling   • negative regulation of catecholamine secretion   • dopamine secretion   • establishment of localization   • regulation of secretion   • catecholamine secretion   • amine transport   • regulation of amine transport   • regulation of dopamine secretion   • developmental process   • multicellular organism development   • multicellular organismal process   • embryo development ending in birth or egg hatching   • chordate embryonic development   • anatomical structure development   • embryo development   • in utero embryonic development   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of macromolecule metabolic process   • positive regulation of cellular process   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of chemokine production   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • chemokine production   • positive regulation of chemokine production   • positive regulation of multicellular organismal process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • biological process involved in interspecies interaction between organisms   • disruption of cell in another organism   • disruption of anatomical structure in another organism   • killing of cells of another organism   • cell killing   • glomerulus development   • animal organ development   • nephron development   • kidney development   • renal system development   • system development   • inflammatory response to wounding   • response to wounding   • complement activation, alternative pathway   • response to biotic stimulus   • innate immune response   • response to external biotic stimulus   • response to other organism   • defense response to symbiont   • defense response to other organism   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • regulation of vascular endothelial growth factor production   • vascular endothelial growth factor production   • positive regulation of vascular endothelial growth factor production   • complement activation, lectin pathway   • complement activation, GZMK pathway   • regulation of developmental process   • angiogenesis   • regulation of vasculature development   • positive regulation of developmental process   • tube morphogenesis   • regulation of anatomical structure morphogenesis   • blood vessel development   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • positive regulation of angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • multicellular organismal-level homeostasis   • leukocyte homeostasis   • homeostasis of number of cells   • myeloid cell homeostasis   • neutrophil homeostasis   • negative regulation of norepinephrine secretion   • norepinephrine transport   • organic cation transport   • norepinephrine secretion   • regulation of norepinephrine secretion   • cell periphery   • protein-containing complex   • cellular anatomical structure   • plasma membrane protein complex   • membrane   • plasma membrane   • membrane protein complex   • pore complex   • membrane attack complex   • other organism cell membrane   • other organism part   • extracellular region   • extracellular space   • transmembrane transporter complex
Gene OntologyCellular Component• cell periphery   • protein-containing complex   • cellular anatomical structure   • plasma membrane protein complex   • membrane   • plasma membrane   • membrane protein complex   • pore complex   • membrane attack complex   • other organism cell membrane   • other organism part   • extracellular region   • extracellular space   • transmembrane transporter complex   • transporter complex   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • cytoplasmic side of membrane   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • organelle   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • mu-type opioid receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • cation binding   • metal ion binding   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • heart process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • postsynapse   • postsynaptic membrane   • plasma membrane region   • synaptic membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • neurotransmitter receptor activity   • G protein-coupled amine receptor activity   • G protein-coupled acetylcholine receptor activity   • postsynaptic neurotransmitter receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • G protein-coupled neurotransmitter receptor activity   • acetylcholine receptor activity   • opsonin receptor activity   • complement receptor activity   • complement component C5a receptor activity   • immune receptor activity   • complement component C5a binding   • complement binding   • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway   • cell surface receptor signaling pathway   • regulation of locomotion   • locomotion   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • positive regulation of cytosolic calcium ion concentration   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • positive regulation of cellular process   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • regulation of cytokine production   • cytokine production   • positive regulation of macromolecule metabolic process   • regulation of vascular endothelial growth factor production   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • vascular endothelial growth factor production   • biosynthetic process   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • positive regulation of vascular endothelial growth factor production   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • positive regulation of cytokine production   • regulation of metabolic process   • cellular component organization   • cell junction organization   • presynapse organization   • synapse organization   • cellular component organization or biogenesis   • immune response-regulating cell surface receptor signaling pathway   • complement receptor mediated signaling pathway   • immune response-activating signaling pathway   • immune response-regulating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • positive regulation of immune system process   • immune response-activating cell surface receptor signaling pathway   • immune response   • immune system process   • regulation of immune response   • activation of immune response   • amyloid-beta clearance   • cell chemotaxis   • chemotaxis   • neutrophil chemotaxis   • response to external stimulus   • neutrophil migration   • granulocyte migration   • leukocyte migration   • taxis   • granulocyte chemotaxis   • myeloid leukocyte migration   • cell migration   • cell motility   • leukocyte chemotaxis   • cognition   • positive regulation of cell population proliferation   • positive regulation of epithelial cell proliferation   • regulation of cell population proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • head development   • brain development   • nervous system development   • central nervous system development   • cell proliferation in hindbrain   • neural precursor cell proliferation   • hindbrain development   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of chemotaxis   • positive regulation of cell migration   • positive regulation of neutrophil chemotaxis   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of leukocyte chemotaxis   • positive regulation of granulocyte chemotaxis   • regulation of neutrophil chemotaxis   • regulation of neutrophil migration   • regulation of response to external stimulus   • regulation of granulocyte chemotaxis   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • positive regulation of leukocyte migration   • positive regulation of neutrophil migration   • regulation of chemotaxis   • neuron apoptotic process   • negative regulation of neuron apoptotic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of neuron apoptotic process   • macrophage migration   • regulation of mononuclear cell migration   • positive regulation of macrophage migration   • macrophage chemotaxis   • regulation of macrophage migration   • positive regulation of mononuclear cell migration   • regulation of macrophage chemotaxis   • mononuclear cell migration   • positive regulation of macrophage chemotaxis   • cellular developmental process   • astrocyte differentiation   • cell development   • astrocyte activation   • glial cell development   • neurogenesis   • astrocyte development   • gliogenesis   • cell differentiation   • response to stress   • defense response   • cell activation   • glial cell differentiation   • glial cell activation   • inflammatory response   • neuroinflammatory response   • regulation of developmental process   • angiogenesis   • regulation of vasculature development   • positive regulation of developmental process   • tube morphogenesis   • regulation of anatomical structure morphogenesis   • blood vessel development   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • positive regulation of angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • complement component C5a signaling pathway   • mRNA transcription by RNA polymerase II   • RNA metabolic process   • primary metabolic process   • nucleobase-containing compound biosynthetic process   • mRNA transcription   • mRNA metabolic process   • nucleic acid metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • DNA-templated transcription   • nucleic acid biosynthetic process   • transcription by RNA polymerase II   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • response to peptidoglycan   • myeloid leukocyte activation   • leukocyte activation   • macrophage activation   • leukocyte activation involved in inflammatory response   • microglial cell activation   • defense response to Gram-positive bacterium   • defense response to bacterium   • apical part of cell   • cell surface   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • cytoplasmic vesicle   • intracellular vesicle
SCOP2Domain Identifier• Anaphylotoxins (complement system)   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Anaphylotoxins (complement system)   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinC5a-des-Arg
UniProtP06684
Sequence
>9KWX_nogp_Chain_L
LLRQKIEEQ AAKYKHSVP KKCCYDGAR VNFCEERVA RVTLCIRAF 
NECCTIANK IRKESPHKP VQLG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30993
Sequence
>9KWX_nogp_Chain_R
PADGIHLPK RQPGDVAAL IIYSVVFLV GVPGNALVV WVTAFEARR 
AVNAIWFLN LAVADLLSC LALPVLFTT VLNHNYWYF DATACIVLP 
SLILLNMYA SILLLATIS ADRFLLVFK PIWCQKVRG TGLAWMACG 
VAWVLALLL TIPSFVYRE AYKDFYSEH TVCGINYGG GSFPKEKAV 
AILRLMVGF VLPLLTLNI CYTFLLLRT WSRKATRST KTLKVVMAV 
VICFFIFWL PYQVTGVMI AWLPPSSPT LKRVEKLNS LCVSLAYIN 
CCVNPIIYV MAGQGFHGR LLRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5O9HAPeptideComplement PeptideC5a1Homo sapiens-NDT9513727-2.72018-01-10doi.org/10.1038/nature25025
6C1QAPeptideComplement PeptideC5a1Homo sapiensPMX53NDT9513727-2.92018-05-30doi.org/10.1038/s41594-018-0067-z
6C1RAPeptideComplement PeptideC5a1Homo sapiensPMX53Avacopan; Na-2.22018-05-30doi.org/10.1038/s41594-018-0067-z
7Y64APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y64 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-Gi1/β1/γ23.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-3.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66APeptideComplement PeptideC5a1Homo sapiensBM213-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensBM213-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67APeptideComplement PeptideC5a1Homo sapiensC089 peptide-Gi1/β1/γ22.82023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC089 peptide-2.82023-03-01doi.org/10.1038/s41422-023-00779-2
8HK5APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ232023-05-10doi.org/10.1038/s41589-023-01339-w
8HK5 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-32023-05-10doi.org/10.1038/s41589-023-01339-w
8HPTAPeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-Go/β1/γ23.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HPT (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-3.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQCAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQC (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2APeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZAPeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-Go/β1/γ23.312023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZ (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-3.312023-10-18doi.org/10.1016/j.cell.2023.09.020
9KWGAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9KWG (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.152025-11-2610.1101/2025.05.26.656101
9KWXAPeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.132025-11-2610.1101/2025.05.26.656101
9KWX (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.132025-11-2610.1101/2025.05.26.656101
9KX6APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.112025-11-2610.1101/2025.05.26.656101
9KX6 (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.112025-11-2610.1101/2025.05.26.656101
9KXSAPeptideComplement PeptideC5a1Mus musculusEP67-Go/β1/γ23.312025-11-2610.1101/2025.05.26.656101
9KXS (No Gprot) APeptideComplement PeptideC5a1Mus musculusEP67-3.312025-11-2610.1101/2025.05.26.656101
9UMRAPeptideComplement PeptideC5a1Homo sapiensC5a-pep-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9UMR (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-pep-3.152025-11-2610.1101/2025.05.26.656101
9UMXAPeptideComplement PeptideC5a1Homo sapiensEP54-Go/β1/γ23.22025-11-2610.1101/2025.05.26.656101
9UMX (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP54-3.22025-11-2610.1101/2025.05.26.656101
8JZPAPeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.542025-01-15To be published
8JZP (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.542025-01-15To be published
9KUGAPeptideComplement PeptideC5a1Homo sapiensEP67-Go/β1/γ23.072025-11-2610.1101/2025.05.26.656101
9KUG (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP67-3.072025-11-2610.1101/2025.05.26.656101




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