psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:K2	6.1	Yes	Yes	0	0	0
2	L:L:?1	L:L:P3	5.68	Yes	No	0	0	0
3	L:L:?1	R:R:R178	12.61	Yes	No	0	0	2
4	L:L:?1	R:R:L187	5.99	Yes	No	0	0	4
5	L:L:?1	R:R:G189	2.96	Yes	No	0	0	4
6	L:L:?1	R:R:D191	10.57	Yes	No	0	0	4
7	L:L:K2	R:R:V190	3.04	Yes	No	0	0	5
8	L:L:K2	R:R:F275	4.96	Yes	No	0	0	3
9	L:L:?4	L:L:P3	4.63	Yes	No	1	0	0
10	L:L:P3	R:R:K279	10.04	No	No	1	0	4
11	L:L:?4	L:L:?5	25.53	Yes	No	0	0	0
12	L:L:?4	R:R:L92	2.6	Yes	No	0	0	6
13	L:L:?4	R:R:S95	2.82	Yes	No	0	0	4
14	L:L:?4	R:R:R175	4.57	Yes	Yes	1	0	5
15	L:L:?4	R:R:G189	3.21	Yes	No	1	0	4
16	L:L:?4	R:R:K279	6.63	Yes	No	1	0	4
17	L:L:?5	L:L:?6	19.78	No	Yes	0	0	0
18	L:L:?5	R:R:I116	3.65	No	No	0	0	6
19	L:L:?6	R:R:L117	3.31	Yes	No	0	0	4
20	L:L:?6	R:R:R206	3.88	Yes	No	0	0	6
21	L:L:?6	R:R:Y258	11.22	Yes	Yes	0	0	7
22	L:L:?6	R:R:G262	5.46	Yes	No	0	0	5
23	L:L:?6	R:R:M265	6.77	Yes	No	0	0	4
24	L:L:?6	R:R:D282	7.58	Yes	No	0	0	4
25	R:R:D37	R:R:L33	6.79	No	No	0	4	4
26	R:R:P36	R:R:R34	2.88	No	No	0	3	2
27	R:R:P36	R:R:V35	3.53	No	No	0	3	3
28	R:R:L284	R:R:P36	3.28	No	No	0	4	3
29	R:R:D37	R:R:I96	2.8	No	No	0	4	5
30	R:R:I38	R:R:V42	3.07	No	No	0	5	5
31	R:R:I43	R:R:L39	4.28	Yes	No	0	5	5
32	R:R:L284	R:R:L39	4.15	No	No	0	4	5
33	R:R:A40	R:R:S283	3.42	No	No	0	6	4
34	R:R:F93	R:R:L41	9.74	No	No	0	7	5
35	R:R:I96	R:R:L41	2.85	No	No	0	5	5
36	R:R:I43	R:R:S287	7.74	Yes	No	0	5	4
37	R:R:I291	R:R:I43	2.94	No	Yes	0	5	5
38	R:R:F44	R:R:L89	3.65	Yes	No	5	7	7
39	R:R:F44	R:R:L92	3.65	Yes	No	0	7	6
40	R:R:F44	R:R:S287	7.93	Yes	No	0	7	4
41	R:R:F44	R:R:Y290	7.22	Yes	Yes	5	7	7
42	R:R:F48	R:R:V52	3.93	No	No	0	6	5
43	R:R:F48	R:R:L89	8.53	No	No	0	6	7
44	R:R:F48	R:R:P90	5.78	No	No	0	6	9
45	R:R:C294	R:R:V50	3.42	No	No	0	7	6
46	R:R:F83	R:R:V52	2.62	No	No	0	8	5
47	R:R:D82	R:R:N55	5.39	No	No	0	9	9
48	R:R:F83	R:R:N55	6.04	No	No	0	8	9
49	R:R:F307	R:R:L57	7.31	Yes	No	0	9	5
50	R:R:A79	R:R:V58	3.39	No	No	0	8	8
51	R:R:S314	R:R:W60	9.88	No	No	0	4	4
52	R:R:F307	R:R:V61	5.24	Yes	No	6	9	6
53	R:R:R310	R:R:V61	2.62	Yes	No	6	4	6
54	R:R:L311	R:R:V61	2.98	No	No	0	6	6
55	R:R:L76	R:R:T62	4.42	No	No	0	6	6
56	R:R:T62	R:R:Y300	2.5	No	No	0	6	9
57	R:R:E65	R:R:F64	8.16	No	No	0	5	4
58	R:R:F64	R:R:K313	4.96	No	No	0	4	4
59	R:R:F64	R:R:S314	11.89	No	No	0	4	4
60	R:R:E65	R:R:R310	10.47	No	Yes	0	5	4
61	R:R:A72	R:R:T69	3.36	No	No	0	7	7
62	R:R:I70	R:R:R148	5.01	No	Yes	0	6	7
63	R:R:A153	R:R:I73	3.25	No	No	0	7	6
64	R:R:I73	R:R:W154	8.22	No	No	0	6	3
65	R:R:T129	R:R:W74	6.06	No	Yes	0	6	7
66	R:R:I130	R:R:W74	3.52	No	Yes	0	8	7
67	R:R:D133	R:R:W74	13.4	No	Yes	0	8	7
68	R:R:A153	R:R:W74	5.19	No	Yes	0	7	7
69	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
70	R:R:C157	R:R:W74	2.61	No	Yes	0	6	7
71	R:R:F75	R:R:L78	2.44	Yes	Yes	0	8	9
72	R:R:F75	R:R:I130	2.51	Yes	No	0	8	8
73	R:R:F75	R:R:Y300	16.5	Yes	No	0	8	9
74	R:R:C157	R:R:N77	7.87	No	No	0	6	9
75	R:R:N77	R:R:W161	6.78	No	Yes	0	9	9
76	R:R:L126	R:R:L78	5.54	No	Yes	0	7	9
77	R:R:L127	R:R:L78	2.77	No	Yes	7	8	9
78	R:R:L78	R:R:N296	5.49	Yes	Yes	7	9	9
79	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
80	R:R:C293	R:R:D82	7.78	No	No	0	8	9
81	R:R:D82	R:R:N296	4.04	No	Yes	0	9	9
82	R:R:L84	R:R:N119	4.12	No	Yes	0	6	9
83	R:R:N119	R:R:S85	4.47	Yes	No	0	9	6
84	R:R:L89	R:R:Y290	9.38	No	Yes	5	7	7
85	R:R:I91	R:R:L112	5.71	No	No	0	6	5
86	R:R:I96	R:R:S283	3.1	No	No	0	5	4
87	R:R:Q98	R:R:V97	2.87	No	No	0	4	3
88	R:R:H101	R:R:Q98	14.84	No	No	0	4	4
89	R:R:H99	R:R:K185	5.24	No	No	0	2	3
90	R:R:H100	R:R:L187	2.57	No	No	0	4	4
91	R:R:H101	R:R:P103	19.83	No	No	0	4	3
92	R:R:F104	R:R:W102	4.01	No	Yes	0	7	8
93	R:R:C109	R:R:W102	6.53	No	Yes	1	9	8
94	R:R:V186	R:R:W102	2.45	No	Yes	0	6	8
95	R:R:C188	R:R:W102	10.45	No	Yes	1	9	8
96	R:R:F104	R:R:P103	5.78	No	No	0	7	3
97	R:R:G106	R:R:V177	3.68	No	No	0	3	4
98	R:R:C109	R:R:C188	7.28	No	No	1	9	9
99	R:R:F172	R:R:I111	5.02	No	No	0	4	4
100	R:R:L112	R:R:P113	3.28	No	No	0	5	6
101	R:R:P113	R:R:R175	7.21	No	Yes	0	6	5
102	R:R:S114	R:R:T168	3.2	No	No	8	5	6
103	R:R:S114	R:R:S171	3.26	No	No	0	5	5
104	R:R:F172	R:R:S114	13.21	No	No	8	4	5
105	R:R:L115	R:R:N119	4.12	No	Yes	0	5	9
106	R:R:I116	R:R:Y290	3.63	No	Yes	0	6	7
107	R:R:L117	R:R:Y121	4.69	No	No	0	4	7
108	R:R:L118	R:R:N119	2.75	Yes	Yes	0	5	9
109	R:R:A164	R:R:L118	3.15	No	Yes	0	7	5
110	R:R:L118	R:R:T168	7.37	Yes	No	0	5	6
111	R:R:M120	R:R:Y290	7.18	No	Yes	0	7	7
112	R:R:L167	R:R:Y121	8.21	No	No	3	4	7
113	R:R:R206	R:R:Y121	4.12	No	No	3	6	7
114	R:R:A122	R:R:W161	5.19	No	Yes	0	6	9
115	R:R:I124	R:R:P214	3.39	No	Yes	0	8	9
116	R:R:I124	R:R:W255	5.87	No	No	0	8	9
117	R:R:L125	R:R:L163	4.15	No	No	0	6	4
118	R:R:L127	R:R:N296	4.12	No	Yes	7	8	9
119	R:R:I130	R:R:R134	3.76	No	No	0	8	9
120	R:R:L218	R:R:S131	6.01	No	No	0	8	9
121	R:R:C221	R:R:S131	3.44	No	No	0	6	9
122	R:R:S131	R:R:Y222	12.72	No	Yes	0	9	8
123	R:R:D133	R:R:L137	2.71	No	No	2	8	8
124	R:R:D133	R:R:R148	5.96	No	Yes	2	8	7
125	R:R:R134	R:R:Y222	3.09	No	Yes	0	9	8
126	R:R:F135	R:R:F139	8.57	Yes	No	0	8	7
127	R:R:C221	R:R:F135	9.78	No	Yes	0	6	8
128	R:R:F135	R:R:F224	5.36	Yes	No	0	8	3
129	R:R:F135	R:R:I225	2.51	Yes	No	0	8	8
130	R:R:C144	R:R:L137	3.17	Yes	No	2	5	8
131	R:R:L137	R:R:R148	4.86	No	Yes	2	8	7
132	R:R:F139	R:R:V138	3.93	No	No	9	7	8
133	R:R:I225	R:R:V138	4.61	No	No	0	8	8
134	R:R:R228	R:R:V138	2.62	No	No	9	5	8
135	R:R:F139	R:R:R228	17.1	No	No	9	7	5
136	R:R:F147	R:R:W143	10.02	No	No	0	4	5
137	R:R:C144	R:R:R148	2.79	Yes	Yes	2	5	7
138	R:R:N146	R:R:Q145	2.64	No	No	0	5	5
139	R:R:F147	R:R:N146	4.83	No	No	0	4	5
140	R:R:L167	R:R:R206	4.86	No	No	3	4	6
141	R:R:F172	R:R:T168	2.59	No	No	8	4	6
142	R:R:I169	R:R:P170	3.39	No	No	0	3	8
143	R:R:R175	R:R:S171	3.95	Yes	No	0	5	5
144	R:R:Y174	R:R:Y192	16.88	No	No	0	4	5
145	R:R:D195	R:R:Y174	3.45	No	No	0	3	4
146	R:R:C188	R:R:R175	4.18	No	Yes	1	9	5
147	R:R:G189	R:R:R175	3	No	Yes	1	4	5
148	R:R:D191	R:R:V176	2.92	No	No	0	4	4
149	R:R:E180	R:R:F182	9.33	No	No	0	1	3
150	R:R:E180	R:R:K185	5.4	No	No	0	1	3
151	R:R:F182	R:R:P183	2.89	No	No	0	3	4
152	R:R:V190	R:R:Y192	5.05	No	No	0	5	5
153	R:R:E199	R:R:Y192	21.32	No	No	0	4	5
154	R:R:H194	R:R:S193	5.58	No	No	0	1	4
155	R:R:H194	R:R:K196	3.93	No	No	0	1	2
156	R:R:D195	R:R:R198	3.57	No	No	0	3	3
157	R:R:E199	R:R:S266	7.19	No	No	0	4	5
158	R:R:F267	R:R:R200	8.55	No	No	0	4	3
159	R:R:A203	R:R:S266	3.42	No	No	0	5	5
160	R:R:F267	R:R:I204	5.02	No	No	0	4	3
161	R:R:L207	R:R:Q259	2.66	No	No	0	5	8
162	R:R:I263	R:R:L207	7.14	No	No	0	5	5
163	R:R:G210	R:R:L209	3.42	No	No	0	6	4
164	R:R:F211	R:R:L256	2.44	No	No	0	8	5
165	R:R:F211	R:R:Q259	11.71	No	No	0	8	8
166	R:R:P214	R:R:W213	5.4	Yes	No	0	9	5
167	R:R:T217	R:R:W213	6.06	No	No	0	5	5
168	R:R:F251	R:R:L215	3.65	No	No	0	9	5
169	R:R:F252	R:R:L215	3.65	No	No	0	5	5
170	R:R:I220	R:R:L216	2.85	No	No	0	3	2
171	R:R:I220	R:R:T219	3.04	No	No	0	3	4
172	R:R:F224	R:R:I220	2.51	No	No	0	3	3
173	R:R:V244	R:R:Y222	8.83	No	Yes	0	7	8
174	R:R:V248	R:R:Y222	2.52	No	Yes	0	7	8
175	R:R:L226	R:R:T240	4.42	No	No	0	5	7
176	R:R:L226	R:R:L241	4.15	No	No	0	5	6
177	R:R:L226	R:R:V244	4.47	No	No	0	5	7
178	R:R:R232	R:R:T235	2.59	No	No	0	5	4
179	R:R:K239	R:R:V243	3.04	Yes	No	0	7	7
180	R:R:A303	R:R:K239	3.21	No	Yes	0	6	7
181	R:R:K239	R:R:Q305	2.71	Yes	No	0	7	6
182	R:R:L241	R:R:V245	2.98	No	No	0	6	4
183	R:R:I295	R:R:S250	3.1	No	No	0	7	6
184	R:R:F252	R:R:L256	4.87	No	No	0	5	5
185	R:R:F254	R:R:I253	3.77	Yes	No	0	8	5
186	R:R:F254	R:R:F288	3.22	Yes	No	4	8	8
187	R:R:F254	R:R:I291	6.28	Yes	No	4	8	5
188	R:R:F254	R:R:I295	3.77	Yes	No	0	8	7
189	R:R:W255	R:R:Y258	2.89	No	Yes	0	9	7
190	R:R:N292	R:R:W255	10.17	No	No	0	9	9
191	R:R:L256	R:R:P257	4.93	No	No	0	5	9
192	R:R:Q259	R:R:Y258	5.64	No	Yes	0	8	7
193	R:R:A289	R:R:Y258	4	No	Yes	0	8	7
194	R:R:G262	R:R:T261	3.64	No	Yes	0	5	4
195	R:R:L278	R:R:T261	2.95	No	Yes	0	4	4
196	R:R:C285	R:R:T261	5.07	No	Yes	0	6	4
197	R:R:F267	R:R:I263	5.02	No	No	0	4	5
198	R:R:L278	R:R:M265	2.83	No	No	0	4	4
199	R:R:L268	R:R:S272	3	No	No	10	2	4
200	R:R:L268	R:R:T274	5.9	No	No	10	2	1
201	R:R:F275	R:R:L268	3.65	No	No	0	3	2
202	R:R:E269	R:R:P270	6.29	No	No	0	3	3
203	R:R:P273	R:R:S272	5.34	No	No	0	2	4
204	R:R:S272	R:R:T274	3.2	No	No	10	4	1
205	R:R:V286	R:R:Y290	2.52	No	Yes	0	5	7
206	R:R:F288	R:R:I291	3.77	No	No	4	8	5
207	R:R:N296	R:R:P297	3.26	Yes	No	0	9	9
208	R:R:F307	R:R:V301	3.93	Yes	No	0	9	6
209	R:R:G304	R:R:Q305	3.29	No	No	0	8	6
210	R:R:F307	R:R:R310	8.55	Yes	Yes	6	9	4
211	R:R:G309	R:R:Q308	6.58	No	No	0	5	8
212	R:R:T229	R:R:W230	2.43	No	No	0	8	4
213	R:R:F75	R:R:N71	2.42	Yes	No	0	8	7
214	R:R:L173	R:R:Y174	2.34	No	No	0	4	4
215	R:R:Q308	R:R:R312	2.34	No	No	0	8	5
216	R:R:L125	R:R:W213	2.28	No	No	0	6	5
217	R:R:G105	R:R:G106	2.11	No	No	0	7	3
218	R:R:R310	R:R:Y300	2.06	Yes	No	0	4	9
219	R:R:G210	R:R:P214	2.03	No	Yes	0	6	9
220	R:R:C86	R:R:G51	1.96	No	No	0	5	8
221	R:R:C109	R:R:G106	1.96	No	No	0	9	3
222	R:R:P183	R:R:P184	1.95	No	No	0	4	5
223	R:R:A128	R:R:P214	1.87	No	Yes	0	7	9
224	R:R:G51	R:R:V50	1.84	No	No	0	8	6
225	R:R:P297	R:R:V58	1.77	No	No	0	9	8
226	R:R:P170	R:R:V202	1.77	No	No	0	8	5
227	R:R:C86	R:R:S85	1.72	No	No	0	5	6
228	R:R:A40	R:R:S287	1.71	No	No	0	6	4
229	R:R:C294	R:R:V47	1.71	No	No	0	7	6
230	R:R:G54	R:R:L53	1.71	No	No	0	7	4
231	R:R:A79	R:R:V59	1.7	No	No	0	8	7
232	R:R:A72	R:R:T62	1.68	No	No	0	7	6
233	L:L:K2	R:R:P270	1.67	Yes	No	0	0	3
234	R:R:K140	R:R:P141	1.67	No	No	0	6	8
235	R:R:C294	R:R:I298	1.64	No	No	0	7	7
236	R:R:A66	R:R:I73	1.62	No	No	0	5	6
237	R:R:A150	R:R:I70	1.62	No	No	0	3	6
238	R:R:A88	R:R:I116	1.62	No	No	0	6	6
239	R:R:V59	R:R:V80	1.6	No	No	0	7	5
240	R:R:V243	R:R:V247	1.6	No	No	0	7	7
241	R:R:C144	R:R:L136	1.59	Yes	No	0	5	5
242	R:R:T261	R:R:V260	1.59	Yes	No	0	4	6
243	R:R:A63	R:R:L76	1.58	No	No	0	3	6
244	R:R:A160	R:R:L125	1.58	No	No	0	6	6
245	R:R:A160	R:R:L126	1.58	No	No	0	6	7
246	R:R:T219	R:R:T223	1.57	No	No	0	4	2
247	R:R:I111	R:R:S110	1.55	No	No	0	4	6
248	R:R:I124	R:R:S123	1.55	No	No	0	8	9
249	R:R:I43	R:R:V42	1.54	Yes	No	0	5	5
250	R:R:I155	R:R:V159	1.54	No	No	0	2	1
251	R:R:I204	R:R:V208	1.54	No	No	0	3	4
252	R:R:I298	R:R:V302	1.54	No	No	0	7	6
253	R:R:K239	R:R:S237	1.53	Yes	No	0	7	7
254	R:R:I225	R:R:T229	1.52	No	No	0	8	8
255	R:R:M264	R:R:V260	1.52	No	No	0	4	6
256	R:R:G304	R:R:R310	1.5	No	Yes	0	8	4
257	R:R:L49	R:R:V50	1.49	No	No	0	4	6
258	R:R:L167	R:R:V205	1.49	No	No	0	4	3
259	R:R:L212	R:R:V208	1.49	No	No	0	4	4
260	R:R:I169	R:R:L173	1.43	No	No	0	3	4
261	R:R:E179	R:R:V186	1.43	No	No	0	2	6
262	R:R:E199	R:R:V202	1.43	No	No	0	4	5
263	R:R:G151	R:R:W154	1.41	No	No	0	4	3
264	R:R:G162	R:R:W161	1.41	No	Yes	0	4	9
265	R:R:A45	R:R:F93	1.39	No	No	0	3	7
266	R:R:A108	R:R:F104	1.39	No	No	0	5	7
267	R:R:L49	R:R:L53	1.38	No	No	0	4	4
268	R:R:L118	R:R:L165	1.38	Yes	No	0	5	4
269	R:R:L277	R:R:L281	1.38	No	No	0	1	5
270	R:R:L278	R:R:L281	1.38	No	No	0	4	5
271	R:R:C144	R:R:W143	1.31	Yes	No	0	5	5
272	R:R:K67	R:R:R68	1.24	No	No	0	6	7
273	R:R:K196	R:R:R200	1.24	No	No	0	2	3
274	R:R:F83	R:R:L87	1.22	No	No	0	8	4
275	R:R:F275	R:R:L276	1.22	No	No	0	3	3
276	R:R:E179	R:R:Y181	1.12	No	No	0	2	1
277	R:R:R197	R:R:R198	1.07	No	No	0	1	3
278	R:R:R236	R:R:W230	1	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.31833	6	0	0
2	L:L:K2	3.9425	4	0	0
3	L:L:?4	7.14143	7	1	0
4	L:L:?6	8.28571	7	0	0
5	R:R:I43	4.125	4	0	5
6	R:R:F44	5.6125	4	5	7
7	R:R:W74	5.56167	6	0	7
8	R:R:F75	5.9675	4	0	8
9	R:R:L78	4.06	4	7	9
10	R:R:W102	5.86	4	1	8
11	R:R:L118	3.6625	4	0	5
12	R:R:N119	3.865	4	0	9
13	R:R:F135	6.555	4	0	8
14	R:R:C144	2.215	4	2	5
15	R:R:R148	4.655	4	2	7
16	R:R:W161	3.9925	4	0	9
17	R:R:R175	4.582	5	1	5
18	R:R:P214	3.1725	4	0	9
19	R:R:Y222	6.79	4	0	8
20	R:R:K239	2.6225	4	0	7
21	R:R:F254	4.26	4	4	8
22	R:R:Y258	5.9375	4	0	7
23	R:R:T261	3.3125	4	0	4
24	R:R:Y290	5.986	5	5	7
25	R:R:N296	4.2275	4	7	9
26	R:R:F307	6.2575	4	6	9
27	R:R:R310	5.04	5	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:K2	55.5609	6.1	Yes	Yes	0	0	0
2	L:L:K2	R:R:V190	33.5759	3.04	Yes	No	0	0	5
3	L:L:K2	R:R:F275	15.615	4.96	Yes	No	0	0	3
4	L:L:?1	L:L:P3	31.4707	5.68	Yes	No	0	0	0
5	L:L:?4	L:L:P3	32.4692	4.63	Yes	No	1	0	0
6	L:L:?1	R:R:G189	38.3519	2.96	Yes	No	0	0	4
7	L:L:?4	R:R:G189	32.1684	3.21	Yes	No	1	0	4
8	L:L:?4	L:L:?5	41.8707	25.53	Yes	No	0	0	0
9	L:L:?4	R:R:L92	85.9368	2.6	Yes	No	0	0	6
10	L:L:?5	L:L:?6	50.1414	19.78	No	Yes	0	0	0
11	L:L:?5	R:R:I116	15.1519	3.65	No	No	0	0	6
12	L:L:?6	R:R:Y258	45.1549	11.22	Yes	Yes	0	0	7
13	R:R:F44	R:R:L92	85.8707	3.65	Yes	No	0	7	6
14	R:R:F44	R:R:S287	42.809	7.93	Yes	No	0	7	4
15	R:R:A40	R:R:S287	15.5609	1.71	No	No	0	6	4
16	R:R:A40	R:R:S283	13.6481	3.42	No	No	0	6	4
17	R:R:I96	R:R:S283	11.7233	3.1	No	No	0	5	4
18	R:R:I43	R:R:S287	26.8571	7.74	Yes	No	0	5	4
19	R:R:I291	R:R:I43	11.7955	2.94	No	Yes	0	5	5
20	R:R:F44	R:R:L89	76.5534	3.65	Yes	No	5	7	7
21	R:R:I116	R:R:Y290	14.8391	3.63	No	Yes	0	6	7
22	R:R:F48	R:R:L89	82.5985	8.53	No	No	0	6	7
23	R:R:F48	R:R:V52	81.6601	3.93	No	No	0	6	5
24	R:R:R175	R:R:S171	32.6436	3.95	Yes	No	0	5	5
25	R:R:S114	R:R:S171	31.3564	3.26	No	No	0	5	5
26	R:R:S114	R:R:T168	25.7624	3.2	No	No	8	5	6
27	R:R:L118	R:R:T168	24.7398	7.37	Yes	No	0	5	6
28	R:R:L118	R:R:N119	20.6256	2.75	Yes	Yes	0	5	9
29	R:R:N119	R:R:S85	16.403	4.47	Yes	No	0	9	6
30	R:R:C86	R:R:S85	14.9714	1.72	No	No	0	5	6
31	R:R:C86	R:R:G51	13.5278	1.96	No	No	0	5	8
32	R:R:G51	R:R:V50	12.0722	1.84	No	No	0	8	6
33	R:R:F83	R:R:V52	81.209	2.62	No	No	0	8	5
34	R:R:F83	R:R:N55	80.3429	6.04	No	No	0	8	9
35	R:R:D82	R:R:N55	79.9158	5.39	No	No	0	9	9
36	R:R:D82	R:R:N296	79.2782	4.04	No	Yes	0	9	9
37	R:R:L78	R:R:N296	77.4797	5.49	Yes	Yes	7	9	9
38	R:R:F75	R:R:L78	100	2.44	Yes	Yes	0	8	9
39	R:R:F75	R:R:Y300	37.0767	16.5	Yes	No	0	8	9
40	R:R:R310	R:R:Y300	28.409	2.06	Yes	No	0	4	9
41	R:R:F75	R:R:I130	77.3714	2.51	Yes	No	0	8	8
42	R:R:I130	R:R:W74	47.0436	3.52	No	Yes	0	8	7
43	R:R:D133	R:R:W74	27.2241	13.4	No	Yes	0	8	7
44	R:R:D133	R:R:R148	14.394	5.96	No	Yes	2	8	7
45	R:R:C157	R:R:W74	10.0632	2.61	No	Yes	0	6	7
46	R:R:W255	R:R:Y258	36.3549	2.89	No	Yes	0	9	7
47	R:R:I124	R:R:W255	35.212	5.87	No	No	0	8	9
48	R:R:I124	R:R:P214	34.0571	3.39	No	Yes	0	8	9
49	R:R:P214	R:R:W213	31.6752	5.4	Yes	No	0	9	5
50	R:R:L125	R:R:W213	30.4481	2.28	No	No	0	6	5
51	R:R:A160	R:R:L125	29.209	1.58	No	No	0	6	6
52	R:R:A160	R:R:L126	29.0286	1.58	No	No	0	6	7
53	R:R:C188	R:R:R175	21.8887	4.18	No	Yes	1	9	5
54	R:R:C188	R:R:W102	14.6105	10.45	No	Yes	1	9	8
55	R:R:I130	R:R:R134	38.5023	3.76	No	No	0	8	9
56	R:R:R134	R:R:Y222	37.197	3.09	No	Yes	0	9	8
57	R:R:S131	R:R:Y222	27.2602	12.72	No	Yes	0	9	8
58	R:R:C221	R:R:S131	24.2165	3.44	No	No	0	6	9
59	R:R:D133	R:R:L137	11.3203	2.71	No	No	2	8	8
60	R:R:C221	R:R:F135	22.6767	9.78	No	Yes	0	6	8
61	R:R:C144	R:R:W143	13.0827	1.31	Yes	No	0	5	5
62	R:R:V190	R:R:Y192	31.0496	5.05	No	No	0	5	5
63	R:R:Y174	R:R:Y192	15.7714	16.88	No	No	0	4	5
64	R:R:E199	R:R:Y192	12.9624	21.32	No	No	0	4	5
65	R:R:Q259	R:R:Y258	29.9549	5.64	No	Yes	0	8	7
66	R:R:L207	R:R:Q259	18.0391	2.66	No	No	0	5	8
67	R:R:I263	R:R:L207	16.2887	7.14	No	No	0	5	5
68	R:R:F267	R:R:I263	14.5263	5.02	No	No	0	4	5
69	R:R:F211	R:R:Q259	10.9654	11.71	No	No	0	8	8
70	R:R:G304	R:R:R310	11.5489	1.5	No	Yes	0	8	4
71	R:R:F275	R:R:L268	10.6045	3.65	No	No	0	3	2
72	L:L:?4	R:R:R175	47.1399	4.57	Yes	Yes	1	0	5
73	R:R:L126	R:R:L78	28.8782	5.54	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R178	12.61	0	Yes	No	0	2	0	1
L:L:?1	R:R:L187	5.99	0	Yes	No	0	4	0	1
L:L:?1	R:R:G189	2.96	0	Yes	No	0	4	0	1
L:L:?1	R:R:D191	10.57	0	Yes	No	0	4	0	1
L:L:K2	R:R:V190	3.04	0	Yes	No	0	5	0	1
L:L:K2	R:R:F275	4.96	0	Yes	No	0	3	0	1
L:L:P3	R:R:K279	10.04	1	No	No	0	4	0	1
L:L:?4	R:R:L92	2.6	1	Yes	No	0	6	0	1
L:L:?4	R:R:S95	2.82	1	Yes	No	0	4	0	1
L:L:?4	R:R:R175	4.57	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:G189	3.21	1	Yes	No	0	4	0	1
L:L:?4	R:R:K279	6.63	1	Yes	No	0	4	0	1
L:L:?5	R:R:I116	3.65	0	No	No	0	6	0	1
L:L:?6	R:R:L117	3.31	0	Yes	No	0	4	0	1
L:L:?6	R:R:R206	3.88	0	Yes	No	0	6	0	1
L:L:?6	R:R:Y258	11.22	0	Yes	Yes	0	7	0	1
L:L:?6	R:R:G262	5.46	0	Yes	No	0	5	0	1
L:L:?6	R:R:M265	6.77	0	Yes	No	0	4	0	1
L:L:?6	R:R:D282	7.58	0	Yes	No	0	4	0	1
R:R:F44	R:R:L92	3.65	5	Yes	No	7	6	2	1
R:R:F44	R:R:Y290	7.22	5	Yes	Yes	7	7	2	2
R:R:H100	R:R:L187	2.57	0	No	No	4	4	2	1
R:R:P113	R:R:R175	7.21	0	No	Yes	6	5	2	1
R:R:I116	R:R:Y290	3.63	0	No	Yes	6	7	1	2
R:R:L117	R:R:Y121	4.69	0	No	No	4	7	1	2
R:R:L167	R:R:Y121	8.21	3	No	No	4	7	2	2
R:R:R206	R:R:Y121	4.12	3	No	No	6	7	1	2
R:R:L167	R:R:R206	4.86	3	No	No	4	6	2	1
R:R:R175	R:R:S171	3.95	1	Yes	No	5	5	1	2
R:R:C188	R:R:R175	4.18	1	No	Yes	9	5	2	1
R:R:G189	R:R:R175	3	1	No	Yes	4	5	1	1
R:R:D191	R:R:V176	2.92	0	No	No	4	4	1	2
R:R:V190	R:R:Y192	5.05	0	No	No	5	5	1	2
R:R:W255	R:R:Y258	2.89	0	No	Yes	9	7	2	1
R:R:Q259	R:R:Y258	5.64	0	No	Yes	8	7	2	1
R:R:A289	R:R:Y258	4	0	No	Yes	8	7	2	1
R:R:G262	R:R:T261	3.64	0	No	Yes	5	4	1	2
R:R:L278	R:R:T261	2.95	0	No	Yes	4	4	2	2
R:R:L278	R:R:M265	2.83	0	No	No	4	4	2	1
R:R:F275	R:R:L268	3.65	0	No	No	3	2	1	2
R:R:E269	R:R:P270	6.29	0	No	No	3	3	2	1
L:L:K2	R:R:P270	1.67	0	Yes	No	0	3	0	1
R:R:A88	R:R:I116	1.62	0	No	No	6	6	2	1
R:R:F275	R:R:L276	1.22	0	No	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9UMR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	265
Number of Links	278
Number of Hubs	27
Number of Links mediated by Hubs	112
Number of Communities	10
Number of Nodes involved in Communities	36
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	38840
Length Of Smallest Path	3
Average Path Length	14.9185
Length of Longest Path	35
Minimum Path Strength	1.275
Average Path Strength	5.57368
Maximum Path Strength	22.655
Minimum Path Correlation	0.7
Average Path Correlation	0.931601
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	50.2896
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.1623
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • opsonin receptor activity • complement receptor activity • complement component C5a receptor activity • immune receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response • immune system process • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • immune response-activating cell surface receptor signaling pathway • regulation of immune response • activation of immune response • amyloid-beta clearance • cell chemotaxis • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • taxis • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • cognition • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • macrophage migration • regulation of mononuclear cell migration • positive regulation of macrophage migration • macrophage chemotaxis • regulation of macrophage migration • positive regulation of mononuclear cell migration • regulation of macrophage chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • response to stress • defense response • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • complement component C5a signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • cellular defense response • biological process involved in interspecies interaction between organisms • response to other organism • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • apical part of cell • basal part of cell • basal plasma membrane • basolateral plasma membrane • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MEA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	MEA
Name	N-METHYLPHENYLALANINE
Synonyms
Identifier
Formula	C10 H13 N O2
Molecular Weight	179.216
SMILES
PubChem	6951135
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	ZAL
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	ZAL
Name	3-cyclohexyl-D-alanine
Synonyms
Identifier
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES
PubChem	736026
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0


Code	ALC
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	ALC
Name	3-Cyclohexyl-L-alanine
Synonyms	3-Cyclohexyl-L-alanine beta-Cyclohexyl-alanine beta-Cyclohexyl-L-alanine β-Cyclohexyl-alanine
Identifier
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES
PubChem	712421
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0


Code	DAR
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	DAR
Name	D-arginine
Synonyms	(2R)-2-amino-5-guanidinopentanoic acid
Identifier
Formula	C6 H15 N4 O2
Molecular Weight	175.209
SMILES
PubChem	17753939
Formal Charge	1
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>9UMR_nogp_Chain_R T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E Y F P P K V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KWG	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWX	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.13	2025-11-26	10.1101/2025.05.26.656101
	9KWX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.13	2025-11-26	10.1101/2025.05.26.656101
	9KX6	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.11	2025-11-26	10.1101/2025.05.26.656101
	9KX6 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.11	2025-11-26	10.1101/2025.05.26.656101
	9KXS	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-	Go/β1/γ2	3.31	2025-11-26	10.1101/2025.05.26.656101
	9KXS (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-		3.31	2025-11-26	10.1101/2025.05.26.656101
	9UMR	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMR (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMX	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-	Go/β1/γ2	3.2	2025-11-26	10.1101/2025.05.26.656101
	9UMX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-		3.2	2025-11-26	10.1101/2025.05.26.656101
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.54	2025-01-15	To be published
	9KUG	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-	Go/β1/γ2	3.07	2025-11-26	10.1101/2025.05.26.656101
	9KUG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-		3.07	2025-11-26	10.1101/2025.05.26.656101

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Download 9UMR_nogp.zip

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