psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y1	R:R:P270	4.17	No	No	0	0	3
2	L:L:S2	R:R:D191	5.89	No	No	0	0	4
3	L:L:D5	L:L:F3	2.39	No	Yes	5	0	0
4	L:L:F3	R:R:R178	12.83	Yes	No	0	0	2
5	L:L:F3	R:R:L187	7.31	Yes	No	5	0	4
6	L:L:F3	R:R:G189	4.52	Yes	No	0	0	4
7	L:L:F3	R:R:D191	5.97	Yes	No	0	0	4
8	L:L:K4	L:L:M6	5.76	No	Yes	1	0	0
9	L:L:K4	R:R:V190	3.04	No	Yes	1	0	5
10	L:L:K4	R:R:E199	5.4	No	No	0	0	4
11	L:L:D5	R:R:L187	6.79	No	No	5	0	4
12	L:L:M6	L:L:P7	3.35	Yes	Yes	1	0	0
13	L:L:M6	L:L:R10	2.48	Yes	Yes	1	0	0
14	L:L:M6	R:R:V190	3.04	Yes	Yes	1	0	5
15	L:L:?8	L:L:P7	4.35	No	Yes	0	0	0
16	L:L:P7	L:L:R10	4.32	Yes	Yes	1	0	0
17	L:L:P7	R:R:D282	4.83	Yes	Yes	1	0	4
18	L:L:?8	L:L:?9	24.87	No	Yes	0	0	0
19	L:L:?8	R:R:W102	5.03	No	Yes	0	0	8
20	L:L:?9	L:L:R10	7.41	Yes	Yes	1	0	0
21	L:L:?9	R:R:L92	7.04	Yes	No	0	0	6
22	L:L:?9	R:R:I116	2.9	Yes	No	1	0	6
23	L:L:?9	R:R:L117	2.82	Yes	No	1	0	4
24	L:L:?9	R:R:Y290	7.15	Yes	Yes	1	0	7
25	L:L:R10	R:R:L117	3.64	Yes	No	1	0	4
26	L:L:R10	R:R:Y258	8.23	Yes	Yes	1	0	7
27	L:L:R10	R:R:T261	3.88	Yes	Yes	0	0	4
28	L:L:R10	R:R:G262	3	Yes	No	0	0	5
29	L:L:R10	R:R:D282	10.72	Yes	Yes	1	0	4
30	L:L:R10	R:R:V286	2.62	Yes	No	0	0	5
31	R:R:L33	R:R:V35	2.98	No	No	0	4	3
32	R:R:H99	R:R:L33	5.14	No	No	0	2	4
33	R:R:P36	R:R:V35	3.53	No	No	0	3	3
34	R:R:D37	R:R:V35	8.76	No	No	0	4	3
35	R:R:K280	R:R:P36	6.69	No	No	0	2	3
36	R:R:D37	R:R:I96	9.8	No	No	0	4	5
37	R:R:D37	R:R:S283	4.42	No	No	0	4	4
38	R:R:F93	R:R:L41	12.18	No	No	0	7	5
39	R:R:I96	R:R:L41	2.85	No	No	0	5	5
40	R:R:I43	R:R:S287	7.74	No	Yes	0	5	4
41	R:R:I291	R:R:I43	2.94	Yes	No	0	5	5
42	R:R:F44	R:R:L89	8.53	Yes	No	0	7	7
43	R:R:F44	R:R:L92	7.31	Yes	No	0	7	6
44	R:R:F44	R:R:S287	2.64	Yes	Yes	0	7	4
45	R:R:F44	R:R:Y290	3.09	Yes	Yes	0	7	7
46	R:R:C294	R:R:V47	6.83	No	No	0	7	6
47	R:R:F48	R:R:L49	3.65	No	No	0	6	4
48	R:R:F48	R:R:V52	5.24	No	No	0	6	5
49	R:R:F48	R:R:P90	5.78	No	No	0	6	9
50	R:R:C86	R:R:G51	3.92	No	No	0	5	8
51	R:R:C294	R:R:G51	1.96	No	No	0	7	8
52	R:R:D82	R:R:N55	4.04	Yes	Yes	0	9	9
53	R:R:F83	R:R:N55	2.42	No	Yes	0	8	9
54	R:R:N55	R:R:P297	9.77	Yes	No	0	9	9
55	R:R:A56	R:R:F83	2.77	No	No	0	3	8
56	R:R:F307	R:R:L57	2.44	Yes	No	0	9	5
57	R:R:V58	R:R:Y300	3.79	No	Yes	0	8	9
58	R:R:T62	R:R:V59	3.17	No	No	0	6	7
59	R:R:A79	R:R:V59	3.39	No	No	0	8	7
60	R:R:L315	R:R:W60	2.28	No	No	0	6	4
61	R:R:S314	R:R:V61	3.23	No	No	0	4	6
62	R:R:L76	R:R:T62	5.9	No	No	0	6	6
63	R:R:T62	R:R:Y300	2.5	No	Yes	0	6	9
64	R:R:A72	R:R:E65	3.02	No	No	0	7	5
65	R:R:E65	R:R:R310	9.3	No	Yes	0	5	4
66	R:R:N71	R:R:T69	4.39	No	No	0	7	7
67	R:R:I73	R:R:W154	12.92	No	No	0	6	3
68	R:R:T129	R:R:W74	3.64	No	Yes	0	6	7
69	R:R:I130	R:R:W74	5.87	No	Yes	0	8	7
70	R:R:D133	R:R:W74	13.4	No	Yes	0	8	7
71	R:R:A153	R:R:W74	5.19	No	Yes	0	7	7
72	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
73	R:R:C157	R:R:W74	2.61	No	Yes	0	6	7
74	R:R:F75	R:R:Y300	13.41	No	Yes	0	8	9
75	R:R:L126	R:R:N77	2.75	No	Yes	0	7	9
76	R:R:N77	R:R:W154	3.39	Yes	No	0	9	3
77	R:R:C157	R:R:N77	6.3	No	Yes	0	6	9
78	R:R:N77	R:R:W161	2.26	Yes	Yes	0	9	9
79	R:R:D82	R:R:L78	5.43	Yes	Yes	4	9	9
80	R:R:L78	R:R:S123	4.5	Yes	No	4	9	9
81	R:R:L126	R:R:L78	4.15	No	Yes	0	7	9
82	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
83	R:R:D82	R:R:S85	2.94	Yes	No	4	9	6
84	R:R:D82	R:R:S123	5.89	Yes	No	4	9	9
85	R:R:C293	R:R:D82	3.11	No	Yes	4	8	9
86	R:R:D82	R:R:N296	12.12	Yes	No	0	9	9
87	R:R:L84	R:R:N119	5.49	No	No	0	6	9
88	R:R:C293	R:R:S85	3.44	No	No	4	8	6
89	R:R:A88	R:R:I116	3.25	No	No	0	6	6
90	R:R:L89	R:R:P90	8.21	No	No	0	7	9
91	R:R:F93	R:R:V97	3.93	No	No	0	7	3
92	R:R:H101	R:R:Q98	11.13	No	No	2	4	4
93	R:R:P103	R:R:Q98	3.16	Yes	No	2	3	4
94	R:R:H101	R:R:P103	3.05	No	Yes	2	4	3
95	R:R:H101	R:R:V186	2.77	No	No	0	4	6
96	R:R:P103	R:R:W102	2.7	Yes	Yes	2	3	8
97	R:R:F104	R:R:W102	2	Yes	Yes	2	7	8
98	R:R:C109	R:R:W102	6.53	No	Yes	2	9	8
99	R:R:C188	R:R:W102	7.84	No	Yes	2	9	8
100	R:R:F104	R:R:P103	2.89	Yes	Yes	2	7	3
101	R:R:A108	R:R:F104	4.16	No	Yes	0	5	7
102	R:R:F104	R:R:L112	2.44	Yes	No	0	7	5
103	R:R:G105	R:R:G106	2.11	No	No	0	7	3
104	R:R:C109	R:R:G106	1.96	No	No	0	9	3
105	R:R:C109	R:R:C188	5.46	No	No	2	9	9
106	R:R:P113	R:R:S171	1.78	No	No	0	6	5
107	R:R:P113	R:R:R175	5.76	No	No	0	6	5
108	R:R:S114	R:R:T168	3.2	No	No	0	5	6
109	R:R:S114	R:R:S171	6.52	No	No	0	5	5
110	R:R:F172	R:R:S114	7.93	No	No	0	4	5
111	R:R:I116	R:R:Y290	2.42	No	Yes	1	6	7
112	R:R:L117	R:R:Y121	5.86	No	No	0	4	7
113	R:R:L118	R:R:W161	6.83	Yes	Yes	0	5	9
114	R:R:L118	R:R:L165	2.77	Yes	No	0	5	4
115	R:R:L118	R:R:T168	2.95	Yes	No	0	5	6
116	R:R:N119	R:R:W161	2.26	No	Yes	0	9	9
117	R:R:M120	R:R:W255	2.33	No	Yes	1	7	9
118	R:R:M120	R:R:Y258	3.59	No	Yes	1	7	7
119	R:R:M120	R:R:Y290	4.79	No	Yes	1	7	7
120	R:R:L167	R:R:Y121	2.34	No	No	0	4	7
121	R:R:R206	R:R:Y121	5.14	No	No	0	6	7
122	R:R:A122	R:R:W161	7.78	No	Yes	0	6	9
123	R:R:A122	R:R:A164	1.79	No	No	0	6	7
124	R:R:I124	R:R:P214	3.39	No	No	0	8	9
125	R:R:F251	R:R:I124	2.51	Yes	No	1	9	8
126	R:R:I124	R:R:W255	4.7	No	Yes	1	8	9
127	R:R:A160	R:R:L125	3.15	No	No	0	6	6
128	R:R:L125	R:R:L163	5.54	No	No	0	6	4
129	R:R:A128	R:R:P214	1.87	No	No	0	7	9
130	R:R:I130	R:R:R134	3.76	No	No	0	8	9
131	R:R:L218	R:R:S131	4.5	No	No	7	8	9
132	R:R:S131	R:R:Y222	8.9	No	Yes	7	9	8
133	R:R:D133	R:R:L137	2.71	No	No	6	8	8
134	R:R:D133	R:R:R148	7.15	No	No	6	8	7
135	R:R:R134	R:R:Y222	6.17	No	Yes	0	9	8
136	R:R:F135	R:R:F139	10.72	Yes	Yes	8	8	7
137	R:R:C221	R:R:F135	5.59	No	Yes	0	6	8
138	R:R:F135	R:R:F224	3.22	Yes	No	8	8	3
139	R:R:F135	R:R:I225	2.51	Yes	No	0	8	8
140	R:R:C144	R:R:L137	4.76	No	No	0	5	8
141	R:R:L137	R:R:R148	13.36	No	No	6	8	7
142	R:R:F139	R:R:V138	3.93	Yes	No	0	7	8
143	R:R:I225	R:R:V138	7.68	No	No	0	8	8
144	R:R:F139	R:R:F224	3.22	Yes	No	8	7	3
145	R:R:F139	R:R:R228	8.55	Yes	No	0	7	5
146	R:R:K140	R:R:W143	2.32	No	No	0	6	5
147	R:R:I142	R:R:P141	3.39	No	No	0	5	8
148	R:R:C144	R:R:W143	2.61	No	No	0	5	5
149	R:R:F147	R:R:W143	3.01	No	No	0	4	5
150	R:R:F147	R:R:N146	7.25	No	No	0	4	5
151	R:R:A150	R:R:W154	2.59	No	No	0	3	3
152	R:R:L163	R:R:L167	2.77	No	No	0	4	4
153	R:R:I169	R:R:P170	5.08	No	No	0	3	8
154	R:R:F172	R:R:I169	6.28	No	No	0	4	3
155	R:R:P170	R:R:V202	3.53	No	No	0	8	5
156	R:R:L173	R:R:Y174	9.38	No	No	0	4	4
157	R:R:Y174	R:R:Y192	8.94	No	No	0	4	5
158	R:R:R198	R:R:Y174	7.2	No	No	0	3	4
159	R:R:R175	R:R:V190	6.54	No	Yes	0	5	5
160	R:R:D191	R:R:V176	5.84	No	No	0	4	4
161	R:R:C188	R:R:V177	3.42	No	No	0	9	4
162	R:R:E180	R:R:R178	4.65	No	No	0	1	2
163	R:R:E179	R:R:V186	5.7	No	No	0	2	6
164	R:R:E180	R:R:Y181	4.49	No	No	9	1	1
165	R:R:E180	R:R:F182	11.66	No	No	9	1	3
166	R:R:F182	R:R:Y181	13.41	No	No	9	3	1
167	R:R:F182	R:R:P183	2.89	No	No	0	3	4
168	R:R:P183	R:R:P184	1.95	No	No	0	4	5
169	R:R:V190	R:R:Y192	3.79	Yes	No	0	5	5
170	R:R:E199	R:R:Y192	20.2	No	No	0	4	5
171	R:R:D195	R:R:R198	7.15	No	No	0	3	3
172	R:R:K196	R:R:R200	7.43	No	No	0	2	3
173	R:R:F267	R:R:R200	8.55	No	No	0	4	3
174	R:R:A203	R:R:S266	3.42	No	No	0	5	5
175	R:R:L207	R:R:Q259	6.65	No	No	0	5	8
176	R:R:I263	R:R:L207	5.71	No	No	0	5	5
177	R:R:L209	R:R:V208	2.98	No	No	0	4	4
178	R:R:F211	R:R:F251	3.22	Yes	Yes	1	8	9
179	R:R:F211	R:R:W255	3.01	Yes	Yes	1	8	9
180	R:R:F211	R:R:L256	3.65	Yes	No	0	8	5
181	R:R:F211	R:R:Q259	9.37	Yes	No	0	8	8
182	R:R:P214	R:R:W213	4.05	No	No	0	9	5
183	R:R:T217	R:R:W213	4.85	No	No	0	5	5
184	R:R:F251	R:R:L215	2.44	Yes	No	0	9	5
185	R:R:L218	R:R:Y222	7.03	No	Yes	7	8	8
186	R:R:V244	R:R:Y222	11.36	No	Yes	0	7	8
187	R:R:L226	R:R:W230	2.28	No	No	0	5	4
188	R:R:L226	R:R:T240	2.95	No	No	0	5	7
189	R:R:T229	R:R:W230	3.64	No	No	0	8	4
190	R:R:T229	R:R:T235	3.14	No	No	0	8	4
191	R:R:R236	R:R:W230	10	No	No	0	5	4
192	R:R:K239	R:R:V243	3.04	No	No	0	7	7
193	R:R:A303	R:R:K239	3.21	No	No	0	6	7
194	R:R:F254	R:R:S250	2.64	Yes	No	0	8	6
195	R:R:F251	R:R:W255	8.02	Yes	Yes	1	9	9
196	R:R:F252	R:R:L256	2.44	No	No	0	5	5
197	R:R:F254	R:R:F288	9.65	Yes	No	3	8	8
198	R:R:F254	R:R:I291	3.77	Yes	Yes	3	8	5
199	R:R:F254	R:R:I295	3.77	Yes	No	3	8	7
200	R:R:W255	R:R:Y258	3.86	Yes	Yes	1	9	7
201	R:R:A289	R:R:W255	3.89	No	Yes	1	8	9
202	R:R:N292	R:R:W255	5.65	No	Yes	0	9	9
203	R:R:L256	R:R:P257	3.28	No	No	0	5	9
204	R:R:Q259	R:R:Y258	5.64	No	Yes	0	8	7
205	R:R:A289	R:R:Y258	2.67	No	Yes	1	8	7
206	R:R:L278	R:R:T261	2.95	No	Yes	0	4	4
207	R:R:C285	R:R:T261	5.07	No	Yes	0	6	4
208	R:R:F275	R:R:M265	9.95	No	Yes	1	3	4
209	R:R:L278	R:R:M265	7.07	No	Yes	0	4	4
210	R:R:K279	R:R:M265	2.88	No	Yes	1	4	4
211	R:R:D282	R:R:M265	6.93	Yes	Yes	1	4	4
212	R:R:L268	R:R:T274	7.37	No	No	0	2	1
213	R:R:F275	R:R:L268	2.44	No	No	0	3	2
214	R:R:E269	R:R:P270	7.86	Yes	No	0	3	3
215	R:R:E269	R:R:S272	2.87	Yes	No	0	3	4
216	R:R:P273	R:R:S272	1.78	No	No	0	2	4
217	R:R:F275	R:R:K279	2.48	No	No	1	3	4
218	R:R:D282	R:R:K279	4.15	Yes	No	1	4	4
219	R:R:K280	R:R:L281	4.23	No	No	0	2	5
220	R:R:L284	R:R:S287	4.5	No	Yes	0	4	4
221	R:R:V286	R:R:Y290	3.79	No	Yes	0	5	7
222	R:R:F288	R:R:I291	2.51	No	Yes	3	8	5
223	R:R:I291	R:R:I295	2.94	Yes	No	3	5	7
224	R:R:I295	R:R:N292	2.83	No	No	0	7	9
225	R:R:N296	R:R:P297	8.15	No	No	0	9	9
226	R:R:R310	R:R:Y300	4.12	Yes	Yes	0	4	9
227	R:R:F307	R:R:V301	5.24	Yes	No	0	9	6
228	R:R:A303	R:R:G304	1.95	No	No	0	6	8
229	R:R:G306	R:R:Q308	4.93	No	No	0	7	8
230	R:R:F307	R:R:R310	5.34	Yes	Yes	0	9	4
231	R:R:G309	R:R:Q308	3.29	No	No	0	5	8
232	R:R:K313	R:R:R310	2.48	No	Yes	0	4	4
233	R:R:L315	R:R:S314	3	No	No	0	6	4
234	R:R:G149	R:R:I70	1.76	No	No	0	5	6
235	R:R:P273	R:R:T274	1.75	No	No	0	2	1
236	R:R:G309	R:R:K313	1.74	No	No	0	5	4
237	R:R:C86	R:R:S85	1.72	No	No	0	5	6
238	R:R:A40	R:R:S283	1.71	No	No	0	6	4
239	R:R:A40	R:R:S287	1.71	No	Yes	0	6	4
240	R:R:G54	R:R:L53	1.71	No	No	0	7	4
241	R:R:G54	R:R:L57	1.71	No	No	0	7	5
242	R:R:G162	R:R:L165	1.71	No	No	0	4	4
243	R:R:C221	R:R:T217	1.69	No	No	0	6	5
244	R:R:K140	R:R:P141	1.67	No	No	0	6	8
245	R:R:G304	R:R:Q305	1.64	No	No	0	8	6
246	R:R:G306	R:R:Q305	1.64	No	No	0	7	6
247	R:R:A203	R:R:I263	1.62	No	No	0	5	5
248	R:R:A246	R:R:I299	1.62	No	No	0	5	7
249	R:R:A249	R:R:I253	1.62	No	Yes	0	4	5
250	R:R:V42	R:R:V46	1.6	No	No	0	5	4
251	R:R:V46	R:R:V50	1.6	No	No	0	4	6
252	R:R:V59	R:R:V80	1.6	No	No	0	7	5
253	R:R:S237	R:R:T240	1.6	No	No	0	7	7
254	R:R:V244	R:R:V248	1.6	No	No	0	7	7
255	R:R:C144	R:R:L136	1.59	No	No	0	5	5
256	R:R:T240	R:R:V244	1.59	No	No	0	7	7
257	R:R:T261	R:R:V260	1.59	Yes	No	0	4	6
258	R:R:A63	R:R:L76	1.58	No	No	0	3	6
259	R:R:E179	R:R:P184	1.57	No	No	0	2	5
260	R:R:T219	R:R:T223	1.57	No	No	0	4	2
261	R:R:A79	R:R:N55	1.56	No	Yes	0	8	9
262	R:R:I155	R:R:V159	1.54	No	No	0	2	1
263	R:R:I204	R:R:V205	1.54	No	No	0	3	3
264	R:R:I298	R:R:V302	1.54	No	No	0	7	6
265	R:R:I91	R:R:T94	1.52	No	No	0	6	3
266	R:R:M264	R:R:V260	1.52	No	No	0	4	6
267	R:R:L311	R:R:S314	1.5	No	No	0	6	4
268	R:R:L209	R:R:V205	1.49	No	No	0	4	3
269	R:R:L212	R:R:V208	1.49	No	No	0	4	4
270	R:R:L218	R:R:V247	1.49	No	No	0	8	7
271	R:R:L241	R:R:V245	1.49	No	No	0	6	4
272	R:R:I70	R:R:I73	1.47	No	No	0	6	6
273	R:R:E269	R:R:S271	1.44	Yes	No	0	3	4
274	R:R:I38	R:R:L41	1.43	No	No	0	5	5
275	R:R:I111	R:R:L115	1.43	No	No	0	4	5
276	R:R:L284	R:R:L39	1.38	No	No	0	4	5
277	R:R:L127	R:R:L78	1.38	No	Yes	0	8	9
278	R:R:L115	R:R:L118	1.38	No	Yes	0	5	5
279	R:R:L167	R:R:L209	1.38	No	No	0	4	4
280	R:R:L226	R:R:L241	1.38	No	No	0	5	6
281	R:R:E269	R:R:K196	1.35	Yes	No	0	3	2
282	R:R:H100	R:R:I96	1.33	No	No	0	4	5
283	R:R:F172	R:R:S110	1.32	No	No	0	4	6
284	R:R:F307	R:R:V61	1.31	Yes	No	0	9	6
285	R:R:R68	R:R:T69	1.29	No	No	0	7	7
286	R:R:R232	R:R:T235	1.29	No	No	0	5	4
287	R:R:R236	R:R:T238	1.29	No	No	0	5	5
288	R:R:F252	R:R:I253	1.26	No	Yes	0	5	5
289	R:R:F254	R:R:I253	1.26	Yes	Yes	3	8	5
290	R:R:F288	R:R:I253	1.26	No	Yes	3	8	5
291	R:R:K67	R:R:R68	1.24	No	No	0	6	7
292	R:R:N71	R:R:R148	1.21	No	No	0	7	7
293	R:R:D195	R:R:R197	1.19	No	No	0	3	1
294	R:R:E65	R:R:F64	1.17	No	No	0	5	4
295	R:R:R232	R:R:R233	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F3	6.604	5	5	0
2	L:L:M6	3.6575	4	1	0
3	L:L:P7	4.2125	4	1	0
4	L:L:?9	8.69833	6	1	0
5	L:L:R10	5.14444	9	1	0
6	R:R:F44	5.3925	4	0	7
7	R:R:N55	4.4475	4	0	9
8	R:R:W74	5.55	6	0	7
9	R:R:N77	3.675	4	0	9
10	R:R:L78	3.865	4	4	9
11	R:R:D82	5.58833	6	4	9
12	R:R:W102	4.82	5	2	8
13	R:R:P103	2.95	4	2	3
14	R:R:F104	2.8725	4	2	7
15	R:R:L118	3.4825	4	0	5
16	R:R:F135	5.51	4	8	8
17	R:R:F139	6.605	4	8	7
18	R:R:W161	4.344	5	0	9
19	R:R:V190	4.1025	4	1	5
20	R:R:F211	4.8125	4	1	8
21	R:R:Y222	8.365	4	7	8
22	R:R:F251	4.0475	4	1	9
23	R:R:I253	1.35	4	3	5
24	R:R:F254	4.218	5	3	8
25	R:R:W255	4.49429	7	1	9
26	R:R:Y258	4.798	5	1	7
27	R:R:T261	3.3725	4	0	4
28	R:R:M265	6.7075	4	1	4
29	R:R:E269	3.38	4	0	3
30	R:R:D282	6.6575	4	1	4
31	R:R:S287	4.1475	4	0	4
32	R:R:Y290	4.248	5	1	7
33	R:R:I291	3.04	4	3	5
34	R:R:Y300	5.955	4	0	9
35	R:R:F307	3.5825	4	0	9
36	R:R:R310	5.31	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E180	R:R:R178	10.9436	4.65	No	No	0	1	2
2	R:R:E180	R:R:F182	12.2556	11.66	No	No	9	1	3
3	R:R:F182	R:R:P183	14.947	2.89	No	No	0	3	4
4	R:R:P183	R:R:P184	16.2661	1.95	No	No	0	4	5
5	R:R:E179	R:R:P184	17.4892	1.57	No	No	0	2	5
6	R:R:E179	R:R:V186	18.7087	5.7	No	No	0	2	6
7	R:R:H101	R:R:V186	20.0135	2.77	No	No	0	4	6
8	R:R:H101	R:R:P103	21.2472	3.05	No	Yes	2	4	3
9	R:R:P103	R:R:W102	23.672	2.7	Yes	Yes	2	3	8
10	L:L:?8	R:R:W102	34.9534	5.03	No	Yes	0	0	8
11	L:L:?8	L:L:P7	20.2802	4.35	No	Yes	0	0	0
12	L:L:P7	R:R:D282	14.8439	4.83	Yes	Yes	1	0	4
13	R:R:D282	R:R:M265	19.53	6.93	Yes	Yes	1	4	4
14	R:R:F275	R:R:M265	18.2998	9.95	No	Yes	1	3	4
15	R:R:F275	R:R:L268	33.3961	2.44	No	No	0	3	2
16	R:R:L268	R:R:T274	30.3954	7.37	No	No	0	2	1
17	R:R:P273	R:R:T274	27.3875	1.75	No	No	0	2	1
18	R:R:P273	R:R:S272	24.3725	1.78	No	No	0	2	4
19	R:R:E269	R:R:S272	21.3504	2.87	Yes	No	0	3	4
20	R:R:D282	R:R:K279	19.562	4.15	Yes	No	1	4	4
21	R:R:F275	R:R:K279	18.0865	2.48	No	No	1	3	4
22	L:L:M6	L:L:P7	24.7742	3.35	Yes	Yes	1	0	0
23	L:L:M6	L:L:R10	77.1315	2.48	Yes	Yes	1	0	0
24	L:L:R10	R:R:D282	25.5351	10.72	Yes	Yes	1	0	4
25	L:L:M6	R:R:V190	100	3.04	Yes	Yes	1	0	5
26	L:L:?9	L:L:R10	36.5214	7.41	Yes	Yes	1	0	0
27	L:L:?9	R:R:L92	19.8144	7.04	Yes	No	0	0	6
28	L:L:?9	R:R:Y290	22.8152	7.15	Yes	Yes	1	0	7
29	L:L:R10	R:R:V286	15.7825	2.62	Yes	No	0	0	5
30	R:R:V286	R:R:Y290	15.1568	3.79	No	Yes	0	5	7
31	L:L:R10	R:R:Y258	36.2369	8.23	Yes	Yes	1	0	7
32	R:R:F44	R:R:L92	19.0962	7.31	Yes	No	0	7	6
33	R:R:F44	R:R:S287	42.8643	2.64	Yes	Yes	0	7	4
34	R:R:A40	R:R:S287	33.1793	1.71	No	Yes	0	6	4
35	R:R:A40	R:R:S283	31.0033	1.71	No	No	0	6	4
36	R:R:D37	R:R:S283	28.8203	4.42	No	No	0	4	4
37	R:R:D37	R:R:V35	13.34	8.76	No	No	0	4	3
38	R:R:F44	R:R:Y290	36.1374	3.09	Yes	Yes	0	7	7
39	R:R:D37	R:R:I96	13.5426	9.8	No	No	0	4	5
40	R:R:W255	R:R:Y258	25.3253	3.86	Yes	Yes	1	9	7
41	R:R:F44	R:R:L89	11.2494	8.53	Yes	No	0	7	7
42	R:R:R175	R:R:V190	98.3503	6.54	No	Yes	0	5	5
43	R:R:P113	R:R:R175	97.8596	5.76	No	No	0	6	5
44	R:R:P113	R:R:S171	97.4436	1.78	No	No	0	6	5
45	R:R:S114	R:R:S171	97.0419	6.52	No	No	0	5	5
46	R:R:S114	R:R:T168	94.1407	3.2	No	No	0	5	6
47	R:R:L118	R:R:T168	93.6322	2.95	Yes	No	0	5	6
48	R:R:L118	R:R:W161	90.9834	6.83	Yes	Yes	0	5	9
49	R:R:N77	R:R:W161	87.5702	2.26	Yes	Yes	0	9	9
50	R:R:L126	R:R:N77	53.2497	2.75	No	Yes	0	7	9
51	R:R:L126	R:R:L78	52.3288	4.15	No	Yes	0	7	9
52	R:R:D82	R:R:L78	49.3636	5.43	Yes	Yes	4	9	9
53	R:R:D82	R:R:N55	40.5923	4.04	Yes	Yes	0	9	9
54	R:R:A79	R:R:N55	36.628	1.56	No	Yes	0	8	9
55	R:R:A79	R:R:V59	35.5863	3.39	No	No	0	8	7
56	R:R:T62	R:R:V59	33.4815	3.17	No	No	0	6	7
57	R:R:T62	R:R:Y300	30.246	2.5	No	Yes	0	6	9
58	R:R:R310	R:R:Y300	27.0177	4.12	Yes	Yes	0	4	9
59	R:R:F307	R:R:R310	12.2662	5.34	Yes	Yes	0	9	4
60	R:R:C157	R:R:N77	44.4855	6.3	No	Yes	0	6	9
61	R:R:C157	R:R:W74	43.5007	2.61	No	Yes	0	6	7
62	R:R:D133	R:R:W74	18.0189	13.4	No	Yes	0	8	7
63	R:R:I130	R:R:W74	23.5156	5.87	No	Yes	0	8	7
64	R:R:L117	R:R:Y121	11.5729	5.86	No	No	0	4	7
65	R:R:I124	R:R:W255	14.7621	4.7	No	Yes	1	8	9
66	R:R:I124	R:R:P214	14.2182	3.39	No	No	0	8	9
67	R:R:I130	R:R:R134	22.4348	3.76	No	No	0	8	9
68	R:R:R134	R:R:Y222	21.3575	6.17	No	Yes	0	9	8
69	R:R:D133	R:R:L137	10.9401	2.71	No	No	6	8	8
70	R:R:P214	R:R:W213	11.9071	4.05	No	No	0	9	5
71	R:R:T217	R:R:W213	10.741	4.85	No	No	0	5	5
72	R:R:Q259	R:R:Y258	10.0263	5.64	No	Yes	0	8	7
73	R:R:V244	R:R:Y222	16.8776	11.36	No	Yes	0	7	8
74	R:R:T240	R:R:V244	14.6661	1.59	No	No	0	7	7
75	R:R:L226	R:R:T240	12.2876	2.95	No	No	0	5	7
76	R:R:K313	R:R:R310	11.0076	2.48	No	Yes	0	4	4
77	L:L:?8	L:L:?9	16.2768	24.87	No	Yes	0	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:P270	4.17	0	No	No	0	3	0	1
L:L:S2	R:R:D191	5.89	0	No	No	0	4	0	1
L:L:F3	R:R:R178	12.83	5	Yes	No	0	2	0	1
L:L:F3	R:R:L187	7.31	5	Yes	No	0	4	0	1
L:L:F3	R:R:G189	4.52	5	Yes	No	0	4	0	1
L:L:F3	R:R:D191	5.97	5	Yes	No	0	4	0	1
L:L:K4	R:R:V190	3.04	1	No	Yes	0	5	0	1
L:L:K4	R:R:E199	5.4	1	No	No	0	4	0	1
L:L:D5	R:R:L187	6.79	5	No	No	0	4	0	1
L:L:M6	R:R:V190	3.04	1	Yes	Yes	0	5	0	1
L:L:P7	R:R:D282	4.83	1	Yes	Yes	0	4	0	1
L:L:?8	R:R:W102	5.03	0	No	Yes	0	8	0	1
L:L:?9	R:R:L92	7.04	1	Yes	No	0	6	0	1
L:L:?9	R:R:I116	2.9	1	Yes	No	0	6	0	1
L:L:?9	R:R:L117	2.82	1	Yes	No	0	4	0	1
L:L:?9	R:R:Y290	7.15	1	Yes	Yes	0	7	0	1
L:L:R10	R:R:L117	3.64	1	Yes	No	0	4	0	1
L:L:R10	R:R:Y258	8.23	1	Yes	Yes	0	7	0	1
L:L:R10	R:R:T261	3.88	1	Yes	Yes	0	4	0	1
L:L:R10	R:R:G262	3	1	Yes	No	0	5	0	1
L:L:R10	R:R:D282	10.72	1	Yes	Yes	0	4	0	1
L:L:R10	R:R:V286	2.62	1	Yes	No	0	5	0	1
R:R:F44	R:R:L92	7.31	0	Yes	No	7	6	2	1
R:R:F44	R:R:Y290	3.09	0	Yes	Yes	7	7	2	1
R:R:A88	R:R:I116	3.25	0	No	No	6	6	2	1
R:R:P103	R:R:W102	2.7	2	Yes	Yes	3	8	2	1
R:R:F104	R:R:W102	2	2	Yes	Yes	7	8	2	1
R:R:C109	R:R:W102	6.53	2	No	Yes	9	8	2	1
R:R:C188	R:R:W102	7.84	2	No	Yes	9	8	2	1
R:R:F104	R:R:P103	2.89	2	Yes	Yes	7	3	2	2
R:R:C109	R:R:C188	5.46	2	No	No	9	9	2	2
R:R:I116	R:R:Y290	2.42	1	No	Yes	6	7	1	1
R:R:L117	R:R:Y121	5.86	1	No	No	4	7	1	2
R:R:M120	R:R:W255	2.33	1	No	Yes	7	9	2	2
R:R:M120	R:R:Y258	3.59	1	No	Yes	7	7	2	1
R:R:M120	R:R:Y290	4.79	1	No	Yes	7	7	2	1
R:R:R175	R:R:V190	6.54	0	No	Yes	5	5	2	1
R:R:D191	R:R:V176	5.84	0	No	No	4	4	1	2
R:R:E180	R:R:R178	4.65	9	No	No	1	2	2	1
R:R:V190	R:R:Y192	3.79	1	Yes	No	5	5	1	2
R:R:E199	R:R:Y192	20.2	0	No	No	4	5	1	2
R:R:W255	R:R:Y258	3.86	1	Yes	Yes	9	7	2	1
R:R:A289	R:R:W255	3.89	1	No	Yes	8	9	2	2
R:R:Q259	R:R:Y258	5.64	0	No	Yes	8	7	2	1
R:R:A289	R:R:Y258	2.67	1	No	Yes	8	7	2	1
R:R:L278	R:R:T261	2.95	0	No	Yes	4	4	2	1
R:R:C285	R:R:T261	5.07	0	No	Yes	6	4	2	1
R:R:L278	R:R:M265	7.07	0	No	Yes	4	4	2	2
R:R:K279	R:R:M265	2.88	1	No	Yes	4	4	2	2
R:R:D282	R:R:M265	6.93	1	Yes	Yes	4	4	1	2
R:R:E269	R:R:P270	7.86	0	Yes	No	3	3	2	1
R:R:D282	R:R:K279	4.15	1	Yes	No	4	4	1	2
R:R:V286	R:R:Y290	3.79	0	No	Yes	5	7	1	1
R:R:T261	R:R:V260	1.59	0	Yes	No	4	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KUG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.78
Number of Linked Nodes	267
Number of Links	295
Number of Hubs	36
Number of Links mediated by Hubs	135
Number of Communities	9
Number of Nodes involved in Communities	52
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	52809
Length Of Smallest Path	3
Average Path Length	17.7366
Length of Longest Path	43
Minimum Path Strength	1.18
Average Path Strength	4.61075
Maximum Path Strength	16.14
Minimum Path Correlation	0.7
Average Path Correlation	0.933639
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	47.0215
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.5856
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MLE
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	MLE
Name	N-METHYLLEUCINE
Synonyms
Identifier
Formula	C7 H15 N O2
Molecular Weight	145.199
SMILES
PubChem	2777993
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	0


Code	DAL
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>9KUG_nogp_Chain_R T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q N F R G A G L A W I A C A V A W G L A L L L T I P S F L Y R V V R E E Y F P P K V L C G V D Y S H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R R A T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q G R L R K S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KWG	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWX	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.13	2025-11-26	10.1101/2025.05.26.656101
	9KWX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.13	2025-11-26	10.1101/2025.05.26.656101
	9KX6	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.11	2025-11-26	10.1101/2025.05.26.656101
	9KX6 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.11	2025-11-26	10.1101/2025.05.26.656101
	9KXS	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-	Go/β1/γ2	3.31	2025-11-26	10.1101/2025.05.26.656101
	9KXS (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-		3.31	2025-11-26	10.1101/2025.05.26.656101
	9UMR	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMR (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMX	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-	Go/β1/γ2	3.2	2025-11-26	10.1101/2025.05.26.656101
	9UMX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-		3.2	2025-11-26	10.1101/2025.05.26.656101
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.54	2025-01-15	To be published
	9KUG	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-	Go/β1/γ2	3.07	2025-11-26	10.1101/2025.05.26.656101
	9KUG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-		3.07	2025-11-26	10.1101/2025.05.26.656101

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KUG_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.