Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y690 16.4675435
2L:L:V695 9.0375431
3L:L:C698 4.6439
4L:L:N707 5.41423
5L:L:F728 4.256509
6L:L:L738 6.2725403
7R:R:P35 3.7675424
8R:R:D37 6.9625424
9R:R:Y44 5.844548
10R:R:F48 5.86407
11R:R:T62 4.4125407
12R:R:W74 6.338507
13R:R:D82 7.23489
14R:R:Y101 7.6625405
15R:R:W102 9.884559
16R:R:L112 3.775455
17R:R:W143 5.3725405
18R:R:R148 9.8554107
19R:R:W161 3.944509
20R:R:R175 6.735404
21R:R:K179 5.735403
22R:R:F181 8.11561
23R:R:Y182 11.325473
24R:R:H185 7.5675471
25R:R:Y192 8.5175406
26R:R:V210 3.74404
27R:R:F212 8.8725418
28R:R:L216 7.0825416
29R:R:Y223 9.374519
30R:R:F225 3.7254114
31R:R:T230 3.3625408
32R:R:F252 8.716519
33R:R:W256 9.33618
34R:R:T262 4.3425405
35R:R:I266 4.6925424
36R:R:L276 8.0475421
37R:R:E280 7.29423
38R:R:S288 6.1525445
39R:R:Y291 5.26667647
40R:R:N293 7.3325419
41R:R:F308 6.286598
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:K179 R:R:V187 18.665510.62YesNo031
2L:L:H744 R:R:V187 16.43474.15NoNo031
3L:L:H744 L:L:I742 14.15521.33NoNo033
4L:L:I742 L:L:L738 13.00691.43NoYes033
5L:L:D746 R:R:V187 34.85972.92NoNo011
6L:L:D746 R:R:E280 35.06876.5NoYes213
7L:L:E709 R:R:S273 11.80134.31NoNo052
8R:R:L276 R:R:S273 12.95539.01YesNo012
9R:R:E280 R:R:I266 43.75725.47YesYes234
10L:L:M747 R:R:I266 64.20395.83NoYes044
11L:L:M747 R:R:I190 45.94227.29NoNo044
12R:R:I190 R:R:Y192 16.434713.3NoYes046
13L:L:G750 L:L:M747 95.85058.73NoNo064
14L:L:G750 R:R:R207 96.46054.5NoNo065
15R:R:R207 R:R:Y121 10012.35NoNo057
16R:R:L117 R:R:Y121 37.94967.03NoNo047
17L:L:L749 R:R:L117 37.90386.92NoNo084
18L:L:L749 R:R:M120 18.22455.65NoNo088
19R:R:M120 R:R:Y291 56.69825.99NoYes087
20R:R:Y121 R:R:Y259 63.48225.96NoNo077
21R:R:W256 R:R:Y259 58.93477.72YesNo087
22R:R:M120 R:R:W256 41.54073.49NoYes088
23L:L:L749 R:R:V287 20.79618.94NoNo085
24R:R:V287 R:R:Y291 17.30816.31NoYes457
25R:R:V47 R:R:Y291 16.56643.79NoYes087
26R:R:L89 R:R:Y291 47.5835.86NoYes087
27R:R:C86 R:R:L89 38.00114.76NoNo078
28R:R:C86 R:R:D82 35.21194.67NoYes079
29R:R:D82 R:R:P298 26.55213.22YesNo899
30R:R:P298 R:R:V58 25.31215.3NoNo099
31R:R:T62 R:R:V58 20.96513.17YesNo079
32R:R:T62 R:R:Y301 15.08593.75YesNo079
33R:R:F308 R:R:Y301 12.116317.54YesNo089
34R:R:F252 R:R:W256 39.836815.03YesYes198
35R:R:F252 R:R:L219 35.85347.31YesNo198
36R:R:L219 R:R:Y223 28.2364.69NoYes189
37R:R:R134 R:R:Y223 19.76529.26NoYes099
38R:R:I130 R:R:R134 19.17817.52NoNo099
39R:R:I130 R:R:W74 18.59683.52NoYes097
40R:R:A153 R:R:W74 12.13635.19NoYes087
41R:R:A153 R:R:I73 10.81044.87NoNo086
42R:R:N293 R:R:W256 22.90669.04YesYes198
43R:R:N293 R:R:N297 23.13574.09YesNo199
44R:R:L78 R:R:N297 22.64898.24NoNo099
45R:R:L126 R:R:L78 22.04755.54NoNo089
46R:R:L126 R:R:T129 17.1224.42NoNo087
47R:R:T129 R:R:W74 16.1343.64NoYes077
48R:R:D133 R:R:W74 18.668416.75NoYes087
49R:R:D133 R:R:R148 14.707910.72NoYes1087
50R:R:I190 R:R:R175 30.6938.77NoYes044
51R:R:P113 R:R:R175 13.91758.65NoYes054
52R:R:C144 R:R:R148 10.810412.54NoYes067
53R:R:V245 R:R:Y223 13.06713.88NoYes079
54R:R:L227 R:R:V245 10.89925.96NoNo047
55R:R:K199 R:R:Y192 13.00695.97NoYes016
56R:R:F253 R:R:L216 10.10028.53NoYes066
57R:R:I292 R:R:V47 12.11633.07NoNo068
58R:R:F255 R:R:I292 10.621413.82NoNo096
59R:R:I266 R:R:L276 18.71425.71YesYes241
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Q680 R:R:F181 12.88 0 No Yes 1 1 0 1
L:L:I683 R:R:F181 11.3 6 No Yes 6 1 0 1
L:L:Y700 R:R:F181 8.25 0 No Yes 4 1 0 1
L:L:A703 R:R:F181 6.93 6 No Yes 7 1 0 1
L:L:C704 R:R:Y182 16.13 0 No Yes 1 3 0 1
L:L:N707 R:R:E280 5.26 2 Yes Yes 3 3 0 1
L:L:N707 R:R:K281 4.2 2 Yes No 3 3 0 1
L:L:D708 R:R:R33 10.72 0 No No 3 2 0 1
L:L:D708 R:R:K277 5.53 0 No No 3 2 0 1
L:L:E709 R:R:S273 4.31 0 No No 5 2 0 1
L:L:E709 R:R:K277 6.75 0 No No 5 2 0 1
L:L:R714 R:R:L30 6.07 0 No No 7 1 0 1
L:L:H744 R:R:V187 4.15 0 No No 3 1 0 1
L:L:K745 R:R:Y192 3.58 0 No Yes 4 6 0 1
L:L:D746 R:R:E280 6.5 2 No Yes 1 3 0 1
L:L:M747 R:R:I190 7.29 0 No No 4 4 0 1
L:L:M747 R:R:I266 5.83 0 No Yes 4 4 0 1
L:L:Q748 R:R:N100 14.52 0 No No 5 3 0 1
L:L:L749 R:R:L117 6.92 0 No No 8 4 0 1
L:L:L749 R:R:M120 5.65 0 No No 8 8 0 1
L:L:L749 R:R:V287 8.94 0 No No 8 5 0 1
L:L:G750 R:R:R207 4.5 0 No No 6 5 0 1
R:R:D37 R:R:P35 6.44 2 Yes Yes 4 4 2 2
R:R:K281 R:R:P35 5.02 2 No Yes 3 4 1 2
R:R:D37 R:R:K281 9.68 2 Yes No 4 3 2 1
R:R:V287 R:R:Y44 3.79 4 No Yes 5 8 1 2
R:R:Y291 R:R:Y44 4.96 4 Yes Yes 7 8 2 2
R:R:L92 R:R:Y291 4.69 0 No Yes 6 7 2 2
R:R:L117 R:R:Y121 7.03 0 No No 4 7 1 2
R:R:M120 R:R:W256 3.49 0 No Yes 8 8 1 2
R:R:M120 R:R:Y291 5.99 0 No Yes 8 7 1 2
R:R:R207 R:R:Y121 12.35 0 No No 5 7 1 2
R:R:P170 R:R:R207 4.32 0 No No 7 5 2 1
R:R:I190 R:R:R175 8.77 0 No Yes 4 4 1 2
R:R:K179 R:R:Y182 4.78 0 Yes Yes 3 3 1 1
R:R:K179 R:R:T186 4.5 0 Yes No 3 5 1 2
R:R:K179 R:R:V187 10.62 0 Yes No 3 1 1 1
R:R:E184 R:R:Y182 14.59 7 No Yes 5 3 2 1
R:R:H185 R:R:Y182 9.8 7 Yes Yes 1 3 2 1
R:R:E184 R:R:H185 7.39 7 No Yes 5 1 2 2
R:R:I190 R:R:Y192 13.3 0 No Yes 4 6 1 1
R:R:K199 R:R:Y192 5.97 0 No Yes 1 6 2 1
R:R:E200 R:R:Y192 11.22 0 No Yes 5 6 2 1
R:R:I266 R:R:L276 5.71 2 Yes Yes 4 1 1 2
R:R:E280 R:R:I266 5.47 2 Yes Yes 3 4 1 1
R:R:L276 R:R:S273 9.01 2 Yes No 1 2 2 1
R:R:E280 R:R:L276 11.93 2 Yes Yes 3 1 1 2
R:R:V287 R:R:Y291 6.31 4 No Yes 5 7 1 2
L:L:H744 R:R:G189 3.18 0 No No 3 2 0 1
L:L:V705 R:R:K179 3.04 0 No Yes 4 3 0 1
R:R:L92 R:R:T95 2.95 0 No No 6 5 2 1
L:L:D746 R:R:V187 2.92 2 No No 1 1 0 1
R:R:K277 R:R:R278 2.48 0 No No 2 1 1 2
R:R:P270 R:R:P271 1.95 0 No No 3 1 2 1
L:L:S743 R:R:P271 1.78 0 No No 3 1 0 1
R:R:G263 R:R:I266 1.76 0 No Yes 6 4 2 1
R:R:L30 R:R:P31 1.64 0 No No 1 3 1 2
L:L:Q748 R:R:T95 1.42 0 No No 5 5 0 1
R:R:D180 R:R:F181 1.19 0 No Yes 1 1 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9KX6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.2
Number of Linked Nodes 339
Number of Links 354
Number of Hubs 41
Number of Links mediated by Hubs 157
Number of Communities 11
Number of Nodes involved in Communities 52
Number of Links involved in Communities 61
Path Summary
Number Of Nodes in MetaPath 60
Number Of Links MetaPath 59
Number of Shortest Paths 58571
Length Of Smallest Path 3
Average Path Length 15.2557
Length of Longest Path 32
Minimum Path Strength 1.345
Average Path Strength 6.62686
Maximum Path Strength 24.76
Minimum Path Correlation 0.7
Average Path Correlation 0.952423
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 66.28
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 29.0245
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Anaphylotoxins (complement system)
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Anaphylotoxins (complement system)
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinC5a-des-Arg
UniProtP01031
Sequence
>9KX6_nogp_Chain_L
TLQKKIEEI AAKYKHSVV KKCCYDGAC VNNDETCEQ RAARISLGP 
RCIKAFTEC CVVASQLRA NISHKDMQL G


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30993
Sequence
>9KX6_nogp_Chain_R
PADGIHLPK RQPGDVAAL IIYSVVFLV GVPGNALVV WVTAFEARR 
AVNAIWFLN LAVADLLSC LALPVLFTT VLNHNYWYF DATACIVLP 
SLILLNMYA SILLLATIS ADRFLLVFK PIWCQKVRG TGLAWMACG 
VAWVLALLL TIPSFVYRE AYKDFYSEH TVCGINYGG GSFPKEKAV 
AILRLMVGF VLPLLTLNI CYTFLLLRT WSRKATRST KTLKVVMAV 
VICFFIFWL PYQVTGVMI AWLPPSSPT LKRVEKLNS LCVSLAYIN 
CCVNPIIYV MAGQGFHGR LLRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5O9HAPeptideComplement PeptideC5a1Homo sapiens-NDT9513727-2.72018-01-10doi.org/10.1038/nature25025
6C1QAPeptideComplement PeptideC5a1Homo sapiensPMX53NDT9513727-2.92018-05-30doi.org/10.1038/s41594-018-0067-z
6C1RAPeptideComplement PeptideC5a1Homo sapiensPMX53Avacopan; Na-2.22018-05-30doi.org/10.1038/s41594-018-0067-z
7Y64APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y64 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-Gi1/β1/γ23.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-3.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66APeptideComplement PeptideC5a1Homo sapiensBM213-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensBM213-2.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67APeptideComplement PeptideC5a1Homo sapiensC089 peptide-Gi1/β1/γ22.82023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC089 peptide-2.82023-03-01doi.org/10.1038/s41422-023-00779-2
8HK5APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ232023-05-10doi.org/10.1038/s41589-023-01339-w
8HK5 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-32023-05-10doi.org/10.1038/s41589-023-01339-w
8HPTAPeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-Go/β1/γ23.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HPT (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-3.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQCAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQC (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2APeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2 (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZAPeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-Go/β1/γ23.312023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZ (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-3.312023-10-18doi.org/10.1016/j.cell.2023.09.020
9KWGAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9KWG (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-3.152025-11-2610.1101/2025.05.26.656101
9KWXAPeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.132025-11-2610.1101/2025.05.26.656101
9KWX (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.132025-11-2610.1101/2025.05.26.656101
9KX6APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.112025-11-2610.1101/2025.05.26.656101
9KX6 (No Gprot) APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-3.112025-11-2610.1101/2025.05.26.656101
9KXSAPeptideComplement PeptideC5a1Mus musculusEP67-Go/β1/γ23.312025-11-2610.1101/2025.05.26.656101
9KXS (No Gprot) APeptideComplement PeptideC5a1Mus musculusEP67-3.312025-11-2610.1101/2025.05.26.656101
9UMRAPeptideComplement PeptideC5a1Homo sapiensC5a-pep-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9UMR (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-pep-3.152025-11-2610.1101/2025.05.26.656101
9UMXAPeptideComplement PeptideC5a1Homo sapiensEP54-Go/β1/γ23.22025-11-2610.1101/2025.05.26.656101
9UMX (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP54-3.22025-11-2610.1101/2025.05.26.656101
8JZPAPeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.542025-01-15To be published
8JZP (No Gprot) APeptideComplement PeptideC5a1Homo sapiensC5a-3.542025-01-15To be published
9KUGAPeptideComplement PeptideC5a1Homo sapiensEP67-Go/β1/γ23.072025-11-2610.1101/2025.05.26.656101
9KUG (No Gprot) APeptideComplement PeptideC5a1Homo sapiensEP67-3.072025-11-2610.1101/2025.05.26.656101




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KX6_nogp.zip



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