psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F3	R:R:Y178	10.32	No	No	0	0	1
2	L:L:D5	L:L:K4	4.15	No	No	0	0	0
3	L:L:M6	R:R:I186	4.37	No	Yes	2	0	5
4	L:L:M6	R:R:Y188	7.18	No	Yes	2	0	9
5	L:L:M6	R:R:E200	2.71	No	No	2	0	5
6	L:L:?8	L:L:P7	2.9	Yes	No	0	0	0
7	L:L:P7	R:R:N283	4.89	No	No	0	0	4
8	L:L:?8	L:L:?9	21.14	Yes	Yes	0	0	0
9	L:L:?8	R:R:L92	8.56	Yes	No	0	0	6
10	L:L:?8	R:R:P113	5.8	Yes	No	0	0	5
11	L:L:?9	L:L:R10	6.18	Yes	Yes	1	0	0
12	L:L:?9	R:R:I116	2.9	Yes	No	0	0	6
13	L:L:?9	R:R:Y259	4.77	Yes	Yes	1	0	7
14	L:L:R10	R:R:Y259	7.2	Yes	Yes	1	0	7
15	L:L:R10	R:R:T262	3.88	Yes	Yes	1	0	5
16	L:L:R10	R:R:N283	13.26	Yes	No	0	0	4
17	L:L:R10	R:R:C286	2.79	Yes	No	1	0	7
18	R:R:D37	R:R:K32	9.68	No	No	0	4	4
19	R:R:P35	R:R:Q34	9.47	No	No	0	4	4
20	R:R:G36	R:R:L285	5.13	No	Yes	0	4	6
21	R:R:D37	R:R:V96	5.84	No	No	0	4	5
22	R:R:A40	R:R:S284	3.42	No	No	0	5	4
23	R:R:A40	R:R:S288	3.42	No	Yes	0	5	5
24	R:R:F93	R:R:L41	14.61	No	No	0	7	4
25	R:R:I43	R:R:S288	9.29	No	Yes	0	5	5
26	R:R:L89	R:R:Y44	4.69	Yes	Yes	3	8	8
27	R:R:V287	R:R:Y44	7.57	No	Yes	3	5	8
28	R:R:S288	R:R:Y44	3.82	Yes	Yes	0	5	8
29	R:R:Y291	R:R:Y44	5.96	Yes	Yes	3	7	8
30	R:R:L89	R:R:V47	2.98	Yes	No	0	8	8
31	R:R:C295	R:R:V47	3.42	No	No	0	8	8
32	R:R:F48	R:R:V52	5.24	No	No	0	7	6
33	R:R:C295	R:R:V50	3.42	No	No	0	8	6
34	R:R:P53	R:R:V52	5.3	No	No	0	4	6
35	R:R:D82	R:R:N55	6.73	No	No	0	9	9
36	R:R:L83	R:R:N55	2.75	No	No	0	8	9
37	R:R:N55	R:R:P298	6.52	No	No	0	9	9
38	R:R:L312	R:R:L57	5.54	No	No	0	6	6
39	R:R:A79	R:R:V58	3.39	No	No	0	9	9
40	R:R:V58	R:R:Y301	5.05	No	No	0	9	9
41	R:R:E65	R:R:V61	4.28	No	No	0	5	7
42	R:R:L76	R:R:T62	7.37	No	No	0	5	7
43	R:R:F64	R:R:S315	15.85	No	No	0	5	6
44	R:R:E65	R:R:R311	12.79	No	No	0	5	5
45	R:R:A69	R:R:N71	3.13	No	No	0	7	8
46	R:R:R148	R:R:V70	11.77	Yes	No	0	7	6
47	R:R:A153	R:R:I73	3.25	No	No	0	8	6
48	R:R:I73	R:R:W154	10.57	No	No	0	6	4
49	R:R:I130	R:R:W74	5.87	No	Yes	0	9	7
50	R:R:D133	R:R:W74	12.28	No	Yes	0	8	7
51	R:R:A153	R:R:W74	3.89	No	Yes	0	8	7
52	R:R:F75	R:R:Y301	17.54	No	No	0	8	9
53	R:R:L76	R:R:N77	4.12	No	No	0	5	9
54	R:R:L126	R:R:N77	6.87	No	No	0	8	9
55	R:R:C157	R:R:N77	9.45	No	No	0	8	9
56	R:R:L126	R:R:L78	2.77	No	No	0	8	9
57	R:R:L127	R:R:L78	5.54	No	No	0	8	9
58	R:R:I130	R:R:L78	2.85	No	No	0	9	9
59	R:R:D82	R:R:S123	4.42	No	No	0	9	9
60	R:R:D82	R:R:N297	2.69	No	Yes	0	9	9
61	R:R:L83	R:R:L87	6.92	No	No	0	8	5
62	R:R:L84	R:R:N119	9.61	No	No	0	7	8
63	R:R:N119	R:R:S85	4.47	No	No	0	8	7
64	R:R:A88	R:R:I116	3.25	No	No	0	7	6
65	R:R:L89	R:R:Y291	3.52	Yes	Yes	3	8	7
66	R:R:L112	R:R:V91	4.47	No	No	0	5	6
67	R:R:L92	R:R:Y291	3.52	No	Yes	0	6	7
68	R:R:N98	R:R:T95	5.85	No	No	0	4	5
69	R:R:Y101	R:R:Y103	18.86	Yes	No	0	5	3
70	R:R:H181	R:R:Y101	8.71	No	Yes	0	1	5
71	R:R:T182	R:R:Y101	3.75	No	Yes	0	3	5
72	R:R:F104	R:R:W102	13.03	No	Yes	0	8	9
73	R:R:C109	R:R:W102	3.92	No	Yes	5	9	9
74	R:R:T182	R:R:W102	4.85	No	Yes	0	3	9
75	R:R:C184	R:R:W102	7.84	No	Yes	5	5	9
76	R:R:D105	R:R:T107	7.23	No	No	0	7	3
77	R:R:A108	R:R:D105	3.09	No	No	0	7	7
78	R:R:A177	R:R:C109	3.61	No	No	0	4	9
79	R:R:C109	R:R:C184	3.64	No	No	5	9	5
80	R:R:L112	R:R:V111	2.98	No	No	0	5	5
81	R:R:P113	R:R:R175	7.21	No	Yes	0	5	4
82	R:R:F172	R:R:S114	13.21	No	No	0	5	6
83	R:R:L117	R:R:Y121	9.38	No	No	0	4	7
84	R:R:L117	R:R:T168	4.42	No	No	0	4	7
85	R:R:L117	R:R:S171	3	No	No	0	4	5
86	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
87	R:R:L118	R:R:L165	2.77	No	No	0	6	4
88	R:R:L118	R:R:T168	2.95	No	No	0	6	7
89	R:R:M120	R:R:Y291	4.79	No	Yes	0	8	7
90	R:R:L167	R:R:Y121	15.24	No	No	0	5	7
91	R:R:R207	R:R:Y121	7.2	No	No	0	5	7
92	R:R:A122	R:R:W161	7.78	No	Yes	0	7	9
93	R:R:I124	R:R:P215	3.39	No	No	0	8	8
94	R:R:L126	R:R:T129	2.95	No	No	0	8	7
95	R:R:L127	R:R:N297	4.12	No	Yes	0	8	9
96	R:R:L219	R:R:S131	3	No	No	6	8	9
97	R:R:C222	R:R:S131	3.44	No	No	0	8	9
98	R:R:S131	R:R:Y223	15.26	No	Yes	6	9	9
99	R:R:D133	R:R:L137	8.14	No	No	0	8	8
100	R:R:R134	R:R:Y223	5.14	No	Yes	0	9	9
101	R:R:F135	R:R:F139	11.79	No	Yes	7	8	8
102	R:R:C222	R:R:F135	8.38	No	No	0	8	8
103	R:R:F135	R:R:F225	4.29	No	No	7	8	4
104	R:R:C144	R:R:L136	3.17	No	No	0	6	6
105	R:R:C144	R:R:L137	4.76	No	No	0	6	8
106	R:R:L137	R:R:R148	7.29	No	Yes	0	8	7
107	R:R:F139	R:R:V138	3.93	Yes	No	0	8	8
108	R:R:L226	R:R:V138	8.94	No	No	0	8	8
109	R:R:F139	R:R:F225	5.36	Yes	No	7	8	4
110	R:R:F139	R:R:R229	5.34	Yes	No	0	8	5
111	R:R:V147	R:R:W143	7.36	No	No	0	4	5
112	R:R:K146	R:R:V147	4.55	No	No	0	5	4
113	R:R:T150	R:R:W154	3.64	No	No	0	1	4
114	R:R:L163	R:R:V159	2.98	No	No	0	4	4
115	R:R:F172	R:R:L165	3.65	No	No	0	5	4
116	R:R:I169	R:R:L166	2.85	No	No	0	4	4
117	R:R:L167	R:R:L206	2.77	No	No	0	5	3
118	R:R:L167	R:R:V210	4.47	No	No	0	5	4
119	R:R:F172	R:R:T168	6.49	No	No	0	5	7
120	R:R:I169	R:R:P170	3.39	No	No	0	4	7
121	R:R:P170	R:R:R207	2.88	No	No	0	7	5
122	R:R:R175	R:R:S171	2.64	Yes	No	0	4	5
123	R:R:V173	R:R:Y174	3.79	No	No	0	4	4
124	R:R:Y174	R:R:Y188	4.96	No	Yes	0	4	9
125	R:R:K199	R:R:Y174	5.97	No	No	0	1	4
126	R:R:C184	R:R:R175	5.57	No	Yes	0	5	4
127	R:R:I186	R:R:R175	12.53	Yes	Yes	0	5	4
128	R:R:E176	R:R:N187	13.15	No	No	0	3	1
129	R:R:D180	R:R:Y178	4.6	No	No	0	1	1
130	R:R:K179	R:R:T182	12.01	No	No	0	3	3
131	R:R:D180	R:R:H181	10.08	No	No	4	1	1
132	R:R:D180	R:R:V183	4.38	No	No	4	1	3
133	R:R:H181	R:R:V183	2.77	No	No	4	1	3
134	R:R:G185	R:R:I186	3.53	No	Yes	0	1	5
135	R:R:I186	R:R:Y188	7.25	Yes	Yes	2	5	9
136	R:R:E200	R:R:Y188	7.86	No	Yes	2	5	9
137	R:R:K201	R:R:W268	8.12	No	No	0	4	4
138	R:R:R207	R:R:V203	5.23	No	No	0	5	5
139	R:R:L208	R:R:M209	4.24	No	No	0	5	6
140	R:R:L208	R:R:Q260	6.65	No	No	0	5	8
141	R:R:L208	R:R:V264	5.96	No	No	0	5	6
142	R:R:F212	R:R:L257	4.87	No	Yes	0	8	6
143	R:R:F212	R:R:Q260	7.03	No	No	0	8	8
144	R:R:L219	R:R:Y223	4.69	No	Yes	6	8	9
145	R:R:F252	R:R:L219	3.65	No	No	0	9	8
146	R:R:N220	R:R:V249	5.91	No	No	0	4	8
147	R:R:V245	R:R:Y223	6.31	No	Yes	0	7	9
148	R:R:L227	R:R:T241	2.95	Yes	No	0	4	7
149	R:R:L227	R:R:L242	4.15	Yes	No	0	4	6
150	R:R:L227	R:R:V245	2.98	Yes	No	0	4	7
151	R:R:R237	R:R:W231	6	No	Yes	0	5	4
152	R:R:L242	R:R:M246	2.83	No	No	0	6	5
153	R:R:I300	R:R:V248	3.07	No	No	0	8	8
154	R:R:I250	R:R:I254	2.94	No	No	0	5	6
155	R:R:C251	R:R:F255	2.79	No	No	0	7	9
156	R:R:C251	R:R:V296	3.42	No	No	0	7	7
157	R:R:F252	R:R:W256	8.02	No	Yes	0	9	8
158	R:R:F253	R:R:L257	7.31	No	Yes	0	6	6
159	R:R:F255	R:R:I254	3.77	No	No	0	9	6
160	R:R:F255	R:R:I292	11.3	No	No	0	9	6
161	R:R:W256	R:R:Y259	4.82	Yes	Yes	1	8	7
162	R:R:A290	R:R:W256	5.19	No	Yes	1	8	8
163	R:R:N293	R:R:W256	5.65	No	Yes	0	9	8
164	R:R:L257	R:R:P258	8.21	Yes	No	0	6	9
165	R:R:A290	R:R:Y259	2.67	No	Yes	1	8	7
166	R:R:C286	R:R:T262	6.76	No	Yes	1	7	5
167	R:R:M265	R:R:V279	3.04	No	No	0	5	4
168	R:R:L269	R:R:P270	4.93	No	No	0	1	3
169	R:R:L269	R:R:L276	2.77	No	No	0	1	1
170	R:R:P270	R:R:S272	3.56	No	No	0	3	1
171	R:R:P274	R:R:S273	5.34	No	No	0	1	2
172	R:R:S273	R:R:T275	7.99	No	No	0	2	1
173	R:R:K281	R:R:L282	9.87	No	No	0	3	5
174	R:R:L285	R:R:S288	3	Yes	Yes	0	6	5
175	R:R:V287	R:R:Y291	7.57	No	Yes	3	5	7
176	R:R:L289	R:R:S288	3	No	Yes	0	7	5
177	R:R:N293	R:R:N297	12.26	No	Yes	0	9	9
178	R:R:N297	R:R:V296	2.96	Yes	No	0	9	7
179	R:R:I300	R:R:V296	3.07	No	No	0	8	7
180	R:R:F308	R:R:H309	4.53	No	No	0	8	7
181	R:R:G310	R:R:H309	4.77	No	No	0	5	7
182	R:R:E280	R:R:N283	2.63	No	No	0	3	4
183	R:R:H99	R:R:K32	2.62	No	No	0	4	4
184	R:R:F104	R:R:V91	2.62	No	No	0	8	6
185	R:R:F308	R:R:V302	2.62	No	No	0	8	7
186	R:R:A156	R:R:W74	2.59	No	Yes	0	5	7
187	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
188	R:R:V249	R:R:Y223	2.52	No	Yes	0	8	9
189	R:R:I110	R:R:R175	2.51	No	Yes	0	7	4
190	R:R:F225	R:R:I221	2.51	No	No	0	4	5
191	R:R:F253	R:R:I254	2.51	No	No	0	6	6
192	R:R:K281	R:R:R278	2.48	No	No	0	3	1
193	R:R:S315	R:R:W60	2.47	No	No	0	6	4
194	R:R:V264	R:R:W268	2.45	No	No	0	6	4
195	R:R:F48	R:R:L49	2.44	No	No	0	7	6
196	R:R:F48	R:R:L89	2.44	No	Yes	0	7	8
197	R:R:T230	R:R:W231	2.43	No	Yes	0	8	4
198	R:R:I124	R:R:W256	2.35	No	Yes	0	8	8
199	R:R:E65	R:R:F64	2.33	No	No	0	5	5
200	R:R:N98	R:R:Y101	2.33	No	Yes	0	4	5
201	R:R:L227	R:R:W231	2.28	Yes	Yes	0	4	4
202	R:R:N119	R:R:W161	2.26	No	Yes	0	8	9
203	R:R:G51	R:R:P53	2.03	No	No	0	8	4
204	R:R:G54	R:R:P53	2.03	No	No	0	8	4
205	R:R:C86	R:R:G51	1.96	No	No	0	7	8
206	R:R:C157	R:R:G158	1.96	No	No	0	8	4
207	R:R:P270	R:R:P271	1.95	No	No	0	3	1
208	R:R:G211	R:R:V210	1.84	No	No	0	6	4
209	R:R:G151	R:R:T150	1.82	No	No	0	4	1
210	R:R:G263	R:R:T262	1.82	No	Yes	0	6	5
211	R:R:A122	R:R:A164	1.79	No	No	0	7	7
212	R:R:A204	R:R:A267	1.79	No	No	0	5	5
213	R:R:G263	R:R:I266	1.76	No	No	0	6	4
214	R:R:C294	R:R:S85	1.72	No	No	0	9	7
215	R:R:A79	R:R:V59	1.7	No	No	0	9	7
216	R:R:G189	R:R:N187	1.7	No	No	0	2	1
217	R:R:A72	R:R:T62	1.68	No	No	0	7	7
218	R:R:A128	R:R:T218	1.68	No	No	0	7	7
219	R:R:A235	R:R:T236	1.68	No	No	0	4	3
220	R:R:K140	R:R:P141	1.67	No	No	0	6	8
221	R:R:L89	R:R:P90	1.64	Yes	No	0	8	8
222	R:R:L214	R:R:P215	1.64	No	No	0	6	8
223	R:R:G307	R:R:Q306	1.64	No	No	0	6	5
224	R:R:S272	R:R:S273	1.63	No	No	0	1	2
225	R:R:S45	R:R:V46	1.62	No	No	0	5	6
226	R:R:V46	R:R:V50	1.6	No	No	0	6	6
227	R:R:S238	R:R:T241	1.6	No	No	0	6	7
228	R:R:V244	R:R:V248	1.6	No	No	0	8	8
229	R:R:T262	R:R:V279	1.59	Yes	No	0	5	4
230	R:R:A39	R:R:L285	1.58	No	Yes	0	5	6
231	R:R:A108	R:R:L112	1.58	No	No	0	7	5
232	R:R:A160	R:R:L125	1.58	No	No	0	7	6
233	R:R:A164	R:R:L125	1.58	No	No	0	7	6
234	R:R:T94	R:R:T95	1.57	No	No	0	5	5
235	R:R:T230	R:R:T236	1.57	No	No	0	8	3
236	R:R:I42	R:R:V46	1.54	No	No	0	5	6
237	R:R:K32	R:R:V38	1.52	No	No	0	4	6
238	R:R:M209	R:R:V213	1.52	No	No	0	6	5
239	R:R:M303	R:R:V302	1.52	No	No	0	7	7
240	R:R:L115	R:R:S114	1.5	No	No	0	6	6
241	R:R:G149	R:R:R148	1.5	No	Yes	0	6	7
242	R:R:K240	R:R:T241	1.5	No	No	0	7	7
243	L:L:S2	R:R:N187	1.49	No	No	0	0	1
244	R:R:L57	R:R:V61	1.49	No	No	0	6	7
245	R:R:L84	R:R:V80	1.49	No	No	0	7	6
246	R:R:L217	R:R:V213	1.49	No	No	0	3	5
247	R:R:L257	R:R:V261	1.49	Yes	No	0	6	6
248	R:R:L276	R:R:V279	1.49	No	No	0	1	4
249	R:R:I205	R:R:M209	1.46	No	No	0	4	6
250	R:R:I299	R:R:M303	1.46	No	No	0	7	7
251	R:R:L152	R:R:M155	1.41	No	No	0	4	3
252	R:R:L125	R:R:L163	1.38	No	No	0	6	4
253	R:R:L282	R:R:L285	1.38	No	Yes	0	5	6
254	R:R:K281	R:R:Q34	1.36	No	No	0	3	4
255	R:R:D37	R:R:L41	1.36	No	No	0	4	4
256	L:L:K4	R:R:E200	1.35	No	No	0	0	5
257	L:L:F3	L:L:S2	1.32	No	No	0	0	0
258	R:R:F93	R:R:S45	1.32	No	No	0	7	5
259	R:R:R314	R:R:S315	1.32	No	No	0	5	6
260	R:R:A267	R:R:W268	1.3	No	No	0	5	4
261	R:R:R233	R:R:T236	1.29	No	No	0	4	3
262	R:R:F93	R:R:L97	1.22	No	No	0	7	3
263	R:R:F212	R:R:L216	1.22	No	No	0	8	6
264	R:R:F252	R:R:L216	1.22	No	No	0	9	6
265	R:R:F75	R:R:N71	1.21	No	No	0	8	8
266	R:R:N71	R:R:R148	1.21	No	Yes	0	8	7
267	R:R:T239	R:R:W231	1.21	No	Yes	0	5	4
268	R:R:K140	R:R:W143	1.16	No	No	0	6	5
269	R:R:R311	R:R:Y301	1.03	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?8	9.6	4	0	0
2	L:L:?9	8.7475	4	1	0
3	L:L:R10	6.662	5	1	0
4	R:R:Y44	5.51	4	3	8
5	R:R:W74	6.1575	4	0	7
6	R:R:L89	3.054	5	3	8
7	R:R:Y101	8.4125	4	0	5
8	R:R:W102	7.41	4	5	9
9	R:R:F139	6.605	4	7	8
10	R:R:R148	5.4425	4	0	7
11	R:R:W161	4.865	4	0	9
12	R:R:R175	6.092	5	0	4
13	R:R:I186	6.92	4	2	5
14	R:R:Y188	6.8125	4	2	9
15	R:R:Y223	6.784	5	6	9
16	R:R:L227	3.09	4	0	4
17	R:R:W231	2.98	4	0	4
18	R:R:W256	5.206	5	1	8
19	R:R:L257	5.47	4	0	6
20	R:R:Y259	4.865	4	1	7
21	R:R:T262	3.5125	4	1	5
22	R:R:L285	2.7725	4	0	6
23	R:R:S288	4.506	5	0	5
24	R:R:Y291	5.072	5	3	7
25	R:R:N297	5.5075	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I186	R:R:R175	19.6965	12.53	Yes	Yes	0	5	4
2	R:R:C184	R:R:R175	39.1444	5.57	No	Yes	0	5	4
3	R:R:C184	R:R:W102	35.0625	7.84	No	Yes	5	5	9
4	R:R:T182	R:R:W102	24.4849	4.85	No	Yes	0	3	9
5	R:R:T182	R:R:Y101	21.6066	3.75	No	Yes	0	3	5
6	R:R:H181	R:R:Y101	14.182	8.71	No	Yes	0	1	5
7	R:R:D180	R:R:H181	11.0748	10.08	No	No	4	1	1
8	R:R:I186	R:R:Y188	10.6365	7.25	Yes	Yes	2	5	9
9	L:L:?8	R:R:P113	85.1115	5.8	Yes	No	0	0	5
10	R:R:P113	R:R:R175	84.5163	7.21	No	Yes	0	5	4
11	L:L:?8	L:L:?9	99.5879	21.14	Yes	Yes	0	0	0
12	L:L:?8	R:R:L92	55.9887	8.56	Yes	No	0	0	6
13	L:L:?9	L:L:R10	11.6112	6.18	Yes	Yes	1	0	0
14	L:L:?9	R:R:Y259	88.1795	4.77	Yes	Yes	1	0	7
15	L:L:R10	R:R:T262	19.7423	3.88	Yes	Yes	1	0	5
16	R:R:L92	R:R:Y291	54.8832	3.52	No	Yes	0	6	7
17	R:R:L89	R:R:Y291	32.0403	3.52	Yes	Yes	3	8	7
18	R:R:L89	R:R:V47	21.6982	2.98	Yes	No	0	8	8
19	R:R:C295	R:R:V47	20.2329	3.42	No	No	0	8	8
20	R:R:C295	R:R:V50	18.7545	3.42	No	No	0	8	6
21	R:R:V46	R:R:V50	17.263	1.6	No	No	0	6	6
22	R:R:S45	R:R:V46	14.2409	1.62	No	No	0	5	6
23	R:R:F93	R:R:S45	12.7101	1.32	No	No	0	7	5
24	R:R:Y291	R:R:Y44	19.4086	5.96	Yes	Yes	3	7	8
25	R:R:S288	R:R:Y44	20.1478	3.82	Yes	Yes	0	5	8
26	R:R:L285	R:R:S288	12.6578	3	Yes	Yes	0	6	5
27	R:R:F48	R:R:L89	11.1664	2.44	No	Yes	0	7	8
28	R:R:W256	R:R:Y259	100	4.82	Yes	Yes	1	8	7
29	R:R:N293	R:R:W256	70.7071	5.65	No	Yes	0	9	8
30	R:R:N293	R:R:N297	69.8371	12.26	No	Yes	0	9	9
31	R:R:L127	R:R:N297	56.2504	4.12	No	Yes	0	8	9
32	R:R:L127	R:R:L78	55.1318	5.54	No	No	0	8	9
33	R:R:I130	R:R:L78	44.4692	2.85	No	No	0	9	9
34	R:R:I130	R:R:W74	43.1936	5.87	No	Yes	0	9	7
35	R:R:D133	R:R:W74	34.0682	12.28	No	Yes	0	8	7
36	R:R:D133	R:R:L137	32.8318	8.14	No	No	0	8	8
37	R:R:L137	R:R:R148	28.6649	7.29	No	Yes	0	8	7
38	R:R:N71	R:R:R148	24.5241	1.21	No	Yes	0	8	7
39	R:R:F75	R:R:N71	21.6393	1.21	No	No	0	8	8
40	R:R:F75	R:R:Y301	20.1478	17.54	No	No	0	8	9
41	R:R:R311	R:R:Y301	14.1362	1.03	No	No	0	5	9
42	R:R:E65	R:R:R311	12.7429	12.79	No	No	0	5	5
43	R:R:L126	R:R:L78	12.7625	2.77	No	No	0	8	9
44	R:R:R175	R:R:S171	45.5093	2.64	Yes	No	0	4	5
45	R:R:L117	R:R:S171	44.2729	3	No	No	0	4	5
46	R:R:L117	R:R:T168	30.0844	4.42	No	No	0	4	7
47	R:R:L118	R:R:T168	22.9345	2.95	No	No	0	6	7
48	R:R:L118	R:R:W161	20.3179	6.83	No	Yes	0	6	9
49	R:R:F104	R:R:W102	11.0224	13.03	No	Yes	0	8	9
50	R:R:L117	R:R:Y121	15.608	9.38	No	No	0	4	7
51	R:R:F252	R:R:W256	61.222	8.02	No	Yes	0	9	8
52	R:R:F252	R:R:L219	40.4134	3.65	No	No	0	9	8
53	R:R:L219	R:R:S131	13.0699	3	No	No	6	8	9
54	R:R:C222	R:R:S131	12.5859	3.44	No	No	0	8	9
55	R:R:L219	R:R:Y223	26.1464	4.69	No	Yes	6	8	9
56	R:R:C222	R:R:F135	11.0421	8.38	No	No	0	8	8
57	R:R:F252	R:R:L216	27.4809	1.22	No	No	0	9	6
58	R:R:F212	R:R:L216	26.1268	1.22	No	No	0	8	6
59	R:R:F212	R:R:Q260	17.4069	7.03	No	No	0	8	8
60	R:R:L208	R:R:Q260	15.8893	6.65	No	No	0	5	8
61	R:R:V245	R:R:Y223	21.5543	6.31	No	Yes	0	7	9
62	R:R:L227	R:R:V245	20.2067	2.98	Yes	No	0	4	7
63	R:R:L227	R:R:W231	11.1467	2.28	Yes	Yes	0	4	4
64	R:R:N297	R:R:V296	14.2409	2.96	Yes	No	0	9	7
65	R:R:T262	R:R:V279	15.438	1.59	Yes	No	0	5	4
66	R:R:L276	R:R:V279	12.527	1.49	No	No	0	1	4
67	R:R:L269	R:R:L276	10.9897	2.77	No	No	0	1	1
68	L:L:R10	R:R:Y259	12.8344	7.2	Yes	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F3	R:R:Y178	10.32	0	No	No	0	1	0	1
L:L:M6	R:R:I186	4.37	2	No	Yes	0	5	0	1
L:L:M6	R:R:Y188	7.18	2	No	Yes	0	9	0	1
L:L:M6	R:R:E200	2.71	2	No	No	0	5	0	1
L:L:P7	R:R:N283	4.89	0	No	No	0	4	0	1
L:L:?8	R:R:L92	8.56	0	Yes	No	0	6	0	1
L:L:?8	R:R:P113	5.8	0	Yes	No	0	5	0	1
L:L:?9	R:R:I116	2.9	1	Yes	No	0	6	0	1
L:L:?9	R:R:Y259	4.77	1	Yes	Yes	0	7	0	1
L:L:R10	R:R:Y259	7.2	1	Yes	Yes	0	7	0	1
L:L:R10	R:R:T262	3.88	1	Yes	Yes	0	5	0	1
L:L:R10	R:R:N283	13.26	1	Yes	No	0	4	0	1
L:L:R10	R:R:C286	2.79	1	Yes	No	0	7	0	1
R:R:A88	R:R:I116	3.25	0	No	No	7	6	2	1
R:R:L92	R:R:Y291	3.52	0	No	Yes	6	7	1	2
R:R:P113	R:R:R175	7.21	0	No	Yes	5	4	1	2
R:R:Y174	R:R:Y188	4.96	0	No	Yes	4	9	2	1
R:R:I186	R:R:R175	12.53	2	Yes	Yes	5	4	1	2
R:R:E176	R:R:N187	13.15	0	No	No	3	1	2	1
R:R:D180	R:R:Y178	4.6	4	No	No	1	1	2	1
R:R:G185	R:R:I186	3.53	0	No	Yes	1	5	2	1
R:R:I186	R:R:Y188	7.25	2	Yes	Yes	5	9	1	1
R:R:E200	R:R:Y188	7.86	2	No	Yes	5	9	1	1
R:R:W256	R:R:Y259	4.82	1	Yes	Yes	8	7	2	1
R:R:A290	R:R:W256	5.19	1	No	Yes	8	8	2	2
R:R:A290	R:R:Y259	2.67	1	No	Yes	8	7	2	1
R:R:C286	R:R:T262	6.76	1	No	Yes	7	5	1	1
R:R:E280	R:R:N283	2.63	0	No	No	3	4	2	1
R:R:G263	R:R:T262	1.82	0	No	Yes	6	5	2	1
R:R:G189	R:R:N187	1.7	0	No	No	2	1	2	1
R:R:T262	R:R:V279	1.59	1	Yes	No	5	4	1	2
L:L:S2	R:R:N187	1.49	0	No	No	0	1	0	1
L:L:K4	R:R:E200	1.35	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KXS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	261
Number of Links	269
Number of Hubs	25
Number of Links mediated by Hubs	93
Number of Communities	7
Number of Nodes involved in Communities	27
Number of Links involved in Communities	31

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	30766
Length Of Smallest Path	3
Average Path Length	14.4727
Length of Longest Path	34
Minimum Path Strength	1.21
Average Path Strength	5.79878
Maximum Path Strength	14.85
Minimum Path Correlation	0.7
Average Path Correlation	0.926585
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.595
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.5673
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • opsonin receptor activity • complement receptor activity • complement component C5a receptor activity • immune receptor activity • protein binding • binding • complement component C5a binding • complement binding • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • amyloid-beta clearance • cell chemotaxis • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • taxis • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • system process • nervous system process • cognition • cell population proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • developmental process • head development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • cell proliferation in hindbrain • neural precursor cell proliferation • hindbrain development • system development • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • macrophage migration • regulation of mononuclear cell migration • positive regulation of macrophage migration • macrophage chemotaxis • regulation of macrophage migration • positive regulation of mononuclear cell migration • regulation of macrophage chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • response to stress • defense response • cell activation • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • complement component C5a signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • biological process involved in interspecies interaction between organisms • response to other organism • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • apical part of cell • cell surface • basal part of cell • basal plasma membrane • basolateral plasma membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • cytoplasmic vesicle • organelle • intracellular vesicle • cytoplasm • intracellular membrane-bounded organelle • vesicle • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MLE
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	MLE
Name	N-METHYLLEUCINE
Synonyms
Identifier
Formula	C7 H15 N O2
Molecular Weight	145.199
SMILES
PubChem	2777993
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	0


Code	DAL
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30993
Sequence	>9KXS_nogp_Chain_R K R Q P G D V A A L I I Y S V V F L V G V P G N A L V V W V T A F E A R R A V N A I W F L N L A V A D L L S C L A L P V L F T T V L N H N Y W Y F D A T A C I V L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P I W C Q K V R G T G L A W M A C G V A W V L A L L L T I P S F V Y R E A Y K D G P K E K A V A I L R L M V G F V L P L L T L N I C Y T F L L L R T W S R K A T R S T K T L K V V M A V V I C F F I F W L P Y Q V T G V M I A W L P P S S P T L K R V E K L N S L C V S L A Y I N C C V N P I I Y V M A G Q G F H G R L L R S H T V C G I N Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a (C-terminal peptide)	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a (C-terminal peptide)	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-des-Arg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KWG	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9KWX	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.13	2025-11-26	10.1101/2025.05.26.656101
	9KWX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.13	2025-11-26	10.1101/2025.05.26.656101
	9KX6	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-	Go/β1/γ2	3.11	2025-11-26	10.1101/2025.05.26.656101
	9KX6 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a-des-Arg	-		3.11	2025-11-26	10.1101/2025.05.26.656101
	9KXS	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-	Go/β1/γ2	3.31	2025-11-26	10.1101/2025.05.26.656101
	9KXS (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	EP67	-		3.31	2025-11-26	10.1101/2025.05.26.656101
	9UMR	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-	Go/β1/γ2	3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMR (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-pep	-		3.15	2025-11-26	10.1101/2025.05.26.656101
	9UMX	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-	Go/β1/γ2	3.2	2025-11-26	10.1101/2025.05.26.656101
	9UMX (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP54	-		3.2	2025-11-26	10.1101/2025.05.26.656101
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a	-		3.54	2025-01-15	To be published
	9KUG	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-	Go/β1/γ2	3.07	2025-11-26	10.1101/2025.05.26.656101
	9KUG (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	EP67	-		3.07	2025-11-26	10.1101/2025.05.26.656101

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KXS_nogp.zip

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