psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S28	8.75	Yes	No	0	0	7
2	L:L:?1	R:R:M31	9.27	Yes	No	1	0	8
3	L:L:?1	R:R:T82	9.67	Yes	No	0	0	8
4	L:L:?1	R:R:I85	5.2	Yes	Yes	1	0	6
5	L:L:?1	R:R:S86	5.47	Yes	No	0	0	8
6	L:L:?1	R:R:V89	8.69	Yes	No	1	0	7
7	L:L:?1	R:R:Y93	4.27	Yes	No	1	0	7
8	L:L:?1	R:R:M116	8.24	Yes	Yes	1	0	7
9	L:L:?1	R:R:T123	3.22	Yes	No	1	0	8
10	L:L:?1	R:R:T185	4.3	Yes	Yes	1	0	8
11	L:L:?1	R:R:W186	6.64	Yes	Yes	1	0	7
12	L:L:?1	R:R:L298	6.05	Yes	Yes	1	0	6
13	L:L:?1	R:R:R302	9.74	Yes	Yes	1	0	8
14	L:L:?1	R:R:S305	17.51	Yes	No	0	0	8
15	L:L:?1	R:R:S308	6.57	Yes	No	1	0	8
16	L:L:?1	R:R:I309	6.24	Yes	No	0	0	9
17	R:R:P25	R:R:S24	5.34	No	No	0	5	6
18	R:R:P25	R:R:S29	3.56	No	No	0	5	4
19	R:R:P25	R:R:Y93	11.13	No	No	0	5	7
20	R:R:I27	R:R:R302	12.53	No	Yes	0	4	8
21	R:R:M31	R:R:R302	3.72	No	Yes	1	8	8
22	R:R:I306	R:R:M31	4.37	No	No	0	4	8
23	R:R:F32	R:R:S86	9.25	No	No	0	8	8
24	R:R:G35	R:R:I309	7.05	No	No	0	9	9
25	R:R:G38	R:R:L37	3.42	No	No	0	9	5
26	R:R:L79	R:R:N39	6.87	No	No	0	8	9
27	R:R:N39	R:R:P312	4.89	No	Yes	0	9	9
28	R:R:E133	R:R:L66	5.3	No	No	0	9	6
29	R:R:G153	R:R:L66	3.42	No	No	0	7	6
30	R:R:F67	R:R:V71	7.87	No	No	0	8	8
31	R:R:F315	R:R:F67	4.29	Yes	No	0	9	8
32	R:R:E73	R:R:V69	4.28	No	No	0	7	7
33	R:R:L154	R:R:V69	4.47	No	No	0	5	7
34	R:R:L70	R:R:V156	4.47	No	Yes	0	7	4
35	R:R:M130	R:R:V71	3.04	No	No	0	9	8
36	R:R:E73	R:R:L157	10.6	No	No	0	7	7
37	R:R:D78	R:R:L74	9.5	No	Yes	1	9	9
38	R:R:L74	R:R:M126	5.65	Yes	No	0	9	8
39	R:R:L127	R:R:L74	4.15	No	Yes	0	8	9
40	R:R:L74	R:R:M130	7.07	Yes	No	1	9	9
41	R:R:F315	R:R:L74	3.65	Yes	Yes	1	9	9
42	R:R:P312	R:R:V75	3.53	Yes	No	0	9	9
43	R:R:F76	R:R:L80	3.65	No	No	0	6	5
44	R:R:T77	R:R:Y161	7.49	No	Yes	0	9	7
45	R:R:D78	R:R:T123	7.23	No	No	1	9	8
46	R:R:D78	R:R:S308	7.36	No	No	1	9	8
47	R:R:C83	R:R:L79	3.17	No	No	0	7	8
48	R:R:L80	R:R:L84	4.15	No	No	0	5	5
49	R:R:F119	R:R:G81	9.03	Yes	No	0	8	9
50	R:R:F119	R:R:L84	4.87	Yes	No	0	8	5
51	R:R:F112	R:R:I85	3.77	No	Yes	1	5	6
52	R:R:A115	R:R:I85	3.25	No	Yes	0	5	6
53	R:R:I85	R:R:M116	5.83	Yes	Yes	1	6	7
54	R:R:F119	R:R:I85	7.54	Yes	Yes	0	8	6
55	R:R:P87	R:R:S86	3.56	No	No	0	7	8
56	R:R:V88	R:R:Y111	6.31	No	No	0	5	6
57	R:R:F112	R:R:V88	5.24	No	No	0	5	5
58	R:R:T185	R:R:V89	3.17	Yes	No	1	8	7
59	R:R:T185	R:R:Y93	6.24	Yes	No	1	8	7
60	R:R:L99	R:R:N96	6.87	No	No	0	4	5
61	R:R:N96	R:R:V100	8.87	No	No	0	5	3
62	R:R:L99	R:R:Q97	5.32	No	No	0	4	3
63	R:R:A103	R:R:V100	3.39	No	No	0	5	3
64	R:R:A101	R:R:Q180	4.55	No	No	0	3	4
65	R:R:C109	R:R:L102	6.35	No	No	0	9	3
66	R:R:C109	R:R:C187	7.28	No	No	0	9	9
67	R:R:T110	R:R:Y178	3.75	No	Yes	0	4	6
68	R:R:F112	R:R:M116	3.73	No	Yes	1	5	7
69	R:R:A113	R:R:Y178	9.34	No	Yes	0	7	6
70	R:R:C168	R:R:F114	4.19	No	No	0	8	7
71	R:R:M116	R:R:S120	3.07	Yes	No	0	7	7
72	R:R:F188	R:R:M116	4.98	Yes	Yes	1	8	7
73	R:R:C168	R:R:T117	3.38	No	Yes	0	8	7
74	R:R:F188	R:R:T117	3.89	Yes	Yes	1	8	7
75	R:R:I189	R:R:T117	3.04	Yes	Yes	1	6	7
76	R:R:T117	R:R:Y200	6.24	Yes	Yes	0	7	7
77	R:R:F118	R:R:F119	15	Yes	Yes	0	7	8
78	R:R:F118	R:R:Y161	7.22	Yes	Yes	0	7	7
79	R:R:F118	R:R:S164	7.93	Yes	No	0	7	7
80	R:R:F118	R:R:L165	3.65	Yes	No	0	7	4
81	R:R:C168	R:R:F118	4.19	No	Yes	0	8	7
82	R:R:S120	R:R:Y200	3.82	No	Yes	0	7	7
83	R:R:F167	R:R:L121	3.65	No	No	0	6	7
84	R:R:L121	R:R:Y200	7.03	No	Yes	0	7	7
85	R:R:S308	R:R:T123	3.2	No	No	1	8	8
86	R:R:L207	R:R:M124	4.24	No	No	0	7	7
87	R:R:I160	R:R:L125	7.14	No	No	0	6	6
88	R:R:L125	R:R:L207	5.54	No	No	0	6	7
89	R:R:M126	R:R:V156	3.04	No	Yes	0	8	4
90	R:R:F273	R:R:L127	3.65	Yes	No	0	8	8
91	R:R:D311	R:R:L127	12.21	Yes	No	0	9	8
92	R:R:F128	R:R:L207	3.65	No	No	0	6	7
93	R:R:F128	R:R:S210	6.61	No	No	0	6	5
94	R:R:F315	R:R:M130	8.71	Yes	No	1	9	9
95	R:R:A131	R:R:V211	5.09	No	No	0	9	8
96	R:R:E133	R:R:Y144	6.73	No	No	0	9	8
97	R:R:N215	R:R:R134	6.03	No	Yes	3	9	9
98	R:R:R134	R:R:V218	3.92	Yes	No	0	9	9
99	R:R:L266	R:R:R134	4.86	No	Yes	3	8	9
100	R:R:M269	R:R:R134	6.2	No	Yes	0	9	9
101	R:R:L136	R:R:Y135	3.52	No	Yes	0	5	6
102	R:R:H140	R:R:Y135	7.62	No	Yes	0	5	6
103	R:R:C214	R:R:Y135	8.06	No	Yes	0	7	6
104	R:R:S217	R:R:Y135	7.63	No	Yes	0	6	6
105	R:R:F143	R:R:L136	3.65	No	No	0	4	5
106	R:R:I138	R:R:S137	3.1	No	No	0	8	9
107	R:R:S137	R:R:Y144	7.63	No	No	0	9	8
108	R:R:I138	R:R:V218	4.61	No	No	0	8	9
109	R:R:G139	R:R:N221	3.39	No	No	0	7	6
110	R:R:F143	R:R:R147	3.21	No	No	0	4	4
111	R:R:V148	R:R:Y144	12.62	No	No	0	5	8
112	R:R:R146	R:R:R147	3.2	No	No	0	5	4
113	R:R:I160	R:R:V156	3.07	No	Yes	0	6	4
114	R:R:L157	R:R:P158	6.57	No	No	0	7	3
115	R:R:L157	R:R:Y161	10.55	No	Yes	0	7	7
116	R:R:F167	R:R:L203	4.87	No	No	0	6	5
117	R:R:L170	R:R:P171	3.28	No	Yes	1	7	9
118	R:R:L170	R:R:Y175	4.69	No	No	0	7	4
119	R:R:L170	R:R:Y196	4.69	No	No	1	7	6
120	R:R:P171	R:R:Y178	6.95	Yes	Yes	0	9	6
121	R:R:P171	R:R:Y196	19.47	Yes	No	1	9	6
122	R:R:L173	R:R:Y175	7.03	No	No	0	3	4
123	R:R:G176	R:R:T194	3.64	No	No	0	8	3
124	R:R:Q177	R:R:R190	16.35	No	No	0	3	5
125	R:R:R190	R:R:V179	7.85	No	No	0	5	4
126	R:R:G184	R:R:Q180	4.93	No	No	0	5	4
127	R:R:W186	R:R:Y181	15.43	Yes	Yes	1	7	8
128	R:R:F188	R:R:Y181	4.13	Yes	Yes	1	8	8
129	R:R:H191	R:R:Y181	6.53	No	Yes	0	6	8
130	R:R:D297	R:R:Y181	6.9	No	Yes	1	6	8
131	R:R:C182	R:R:R292	4.18	No	No	0	3	1
132	R:R:P183	R:R:W186	9.46	No	Yes	0	8	7
133	R:R:T185	R:R:W186	3.64	Yes	Yes	1	8	7
134	R:R:D297	R:R:W186	3.35	No	Yes	1	6	7
135	R:R:L298	R:R:W186	4.56	Yes	Yes	1	6	7
136	R:R:F188	R:R:I189	3.77	Yes	Yes	1	8	6
137	R:R:I189	R:R:Y196	6.04	Yes	No	1	6	6
138	R:R:I189	R:R:L197	5.71	Yes	No	0	6	7
139	R:R:R190	R:R:R193	4.26	No	No	0	5	5
140	R:R:H191	R:R:L197	6.43	No	No	0	6	7
141	R:R:E288	R:R:H191	6.15	No	No	0	5	6
142	R:R:L204	R:R:Y200	9.38	No	Yes	0	7	7
143	R:R:A201	R:R:Y285	5.34	No	No	0	7	5
144	R:R:T202	R:R:Y285	3.75	No	No	0	4	5
145	R:R:L205	R:R:T281	7.37	No	No	0	6	7
146	R:R:F273	R:R:I208	6.28	Yes	Yes	2	8	8
147	R:R:I208	R:R:S277	3.1	Yes	Yes	2	8	9
148	R:R:F273	R:R:V211	10.49	Yes	No	0	8	8
149	R:R:F273	R:R:L212	3.65	Yes	No	0	8	7
150	R:R:A274	R:R:L212	4.73	No	No	0	6	7
151	R:R:L266	R:R:N215	4.12	No	No	3	8	9
152	R:R:N215	R:R:T270	7.31	No	No	0	9	8
153	R:R:F216	R:R:T270	3.89	No	No	0	5	8
154	R:R:I219	R:R:L263	4.28	No	No	0	7	7
155	R:R:I219	R:R:L266	8.56	No	No	0	7	8
156	R:R:N221	R:R:R224	3.62	No	No	0	6	5
157	R:R:L222	R:R:L263	4.15	No	No	0	8	7
158	R:R:I223	R:R:L263	5.71	No	No	0	5	7
159	R:R:E259	R:R:M225	4.06	No	No	0	8	7
160	R:R:E259	R:R:H226	9.85	No	No	0	8	5
161	R:R:E258	R:R:H262	4.92	No	No	0	6	8
162	R:R:E258	R:R:R324	13.96	No	No	0	6	5
163	R:R:D261	R:R:T260	4.34	No	No	0	8	5
164	R:R:D261	R:R:L323	4.07	No	No	0	8	7
165	R:R:D261	R:R:R324	8.34	No	No	0	8	5
166	R:R:H262	R:R:P320	15.25	No	Yes	0	8	7
167	R:R:I264	R:R:L323	8.56	No	No	0	6	7
168	R:R:L265	R:R:P320	3.28	No	Yes	0	8	7
169	R:R:F315	R:R:M269	6.22	Yes	No	0	9	9
170	R:R:I310	R:R:T272	3.04	No	No	0	7	7
171	R:R:F273	R:R:S277	3.96	Yes	Yes	2	8	9
172	R:R:F273	R:R:N307	6.04	Yes	Yes	2	8	9
173	R:R:C276	R:R:V275	3.42	No	No	0	9	5
174	R:R:C276	R:R:I306	4.91	No	No	0	9	4
175	R:R:C276	R:R:N307	3.15	No	Yes	0	9	9
176	R:R:N307	R:R:S277	5.96	Yes	Yes	2	9	9
177	R:R:F303	R:R:P279	8.67	No	No	0	6	9
178	R:R:F283	R:R:I282	7.54	Yes	No	0	4	6
179	R:R:F283	R:R:M286	3.73	Yes	No	0	4	4
180	R:R:F283	R:R:W296	5.01	Yes	No	0	4	3
181	R:R:A300	R:R:F283	4.16	No	Yes	0	7	4
182	R:R:N287	R:R:T289	5.85	No	No	0	6	3
183	R:R:N287	R:R:S290	5.96	No	No	0	6	2
184	R:R:E294	R:R:S290	10.06	No	No	0	3	2
185	R:R:K293	R:R:R292	3.71	No	No	0	3	1
186	R:R:E294	R:R:W296	9.81	No	No	0	3	3
187	R:R:L298	R:R:Q299	3.99	Yes	No	0	6	4
188	R:R:L298	R:R:R302	12.15	Yes	Yes	1	6	8
189	R:R:D311	R:R:N307	9.42	Yes	Yes	0	9	9
190	R:R:D311	R:R:P312	3.22	Yes	Yes	0	9	9
191	R:R:D311	R:R:F315	3.58	Yes	Yes	0	9	9
192	R:R:I317	R:R:W313	4.7	No	No	0	8	6
193	R:R:L318	R:R:W313	4.56	No	No	0	6	6
194	R:R:P320	R:R:P321	5.84	Yes	No	0	7	7
195	R:R:L330	R:R:R327	9.72	No	No	0	5	3
196	R:R:A257	R:R:E259	3.02	No	No	0	5	8
197	R:R:L304	R:R:S120	3	No	No	0	8	7
198	R:R:G192	R:R:R193	3	No	No	0	3	5
199	R:R:L304	R:R:S277	3	No	Yes	0	8	9
200	R:R:L40	R:R:V36	2.98	No	No	0	5	7
201	R:R:L205	R:R:V209	2.98	No	No	0	6	4
202	R:R:L46	R:R:T72	2.95	No	No	0	9	5
203	R:R:I317	R:R:I41	2.94	No	No	4	8	5
204	R:R:P320	R:R:R319	2.88	Yes	No	0	7	9
205	R:R:I208	R:R:L278	2.85	Yes	No	0	8	6
206	R:R:I268	R:R:L265	2.85	No	No	0	5	8
207	R:R:I138	R:R:N221	2.83	No	No	0	8	6
208	R:R:L222	R:R:M225	2.83	No	No	0	8	7
209	R:R:G38	R:R:W313	2.81	No	No	0	9	6
210	R:R:L40	R:R:L79	2.77	No	No	0	5	8
211	R:R:A103	R:R:R95	2.77	No	No	0	5	4
212	R:R:E294	R:R:K293	2.7	No	No	0	3	3
213	R:R:A122	R:R:Y161	2.67	No	Yes	0	7	7
214	R:R:L102	R:R:Q180	2.66	No	No	0	3	4
215	R:R:R150	R:R:V69	2.62	No	No	0	4	7
216	R:R:H68	R:R:L46	2.57	No	No	0	8	9
217	R:R:F303	R:R:I306	2.51	No	No	0	6	4
218	R:R:F32	R:R:L90	2.44	No	No	0	8	7
219	R:R:F114	R:R:L172	2.44	No	No	0	7	4
220	R:R:F280	R:R:L204	2.44	No	No	0	8	7
221	R:R:F280	R:R:L301	2.44	No	No	0	8	7
222	R:R:L220	R:R:R224	2.43	No	No	0	3	5
223	R:R:G152	R:R:G153	2.11	No	No	0	5	7
224	R:R:G176	R:R:P171	2.03	No	Yes	0	8	9
225	R:R:A34	R:R:G35	1.95	No	No	0	6	9
226	R:R:C182	R:R:P183	1.88	No	No	0	3	8
227	R:R:A42	R:R:P312	1.87	No	Yes	0	9	9
228	R:R:A103	R:R:P104	1.87	No	No	0	5	3
229	R:R:A131	R:R:C214	1.81	No	No	0	9	7
230	R:R:A316	R:R:A42	1.79	No	No	0	9	9
231	R:R:A201	R:R:A284	1.79	No	No	0	7	5
232	R:R:A26	R:R:S24	1.71	No	No	0	4	6
233	R:R:A34	R:R:S33	1.71	No	No	0	6	5
234	R:R:A129	R:R:V156	1.7	No	Yes	0	7	4
235	R:R:G22	R:R:Q97	1.64	No	No	0	2	3
236	R:R:G176	R:R:Q177	1.64	No	No	0	8	3
237	R:R:S33	R:R:V30	1.62	No	No	0	5	5
238	R:R:A267	R:R:I219	1.62	No	No	0	5	7
239	R:R:C214	R:R:L132	1.59	No	No	0	7	6
240	R:R:A44	R:R:L45	1.58	No	No	0	4	7
241	R:R:A316	R:R:L46	1.58	No	No	0	9	9
242	R:R:E105	R:R:P104	1.57	No	No	0	4	3
243	R:R:I268	R:R:V314	1.54	No	Yes	0	5	8
244	R:R:I310	R:R:V314	1.54	No	Yes	0	7	8
245	R:R:H140	R:R:P141	1.53	No	No	0	5	9
246	R:R:M286	R:R:S291	1.53	No	No	0	4	1
247	R:R:I208	R:R:T281	1.52	Yes	No	0	8	7
248	R:R:M269	R:R:V314	1.52	No	Yes	0	9	8
249	R:R:A108	R:R:E105	1.51	No	No	0	5	4
250	R:R:L43	R:R:V75	1.49	No	No	0	8	9
251	R:R:L125	R:R:V163	1.49	No	No	0	6	3
252	R:R:L318	R:R:V314	1.49	No	Yes	0	6	8
253	R:R:L99	R:R:T98	1.47	No	No	0	4	4
254	R:R:L199	R:R:T202	1.47	No	No	0	5	4
255	R:R:I41	R:R:L45	1.43	No	No	4	5	7
256	R:R:I317	R:R:L45	1.43	No	No	4	8	7
257	R:R:L330	R:R:M326	1.41	No	No	0	5	4
258	R:R:H68	R:R:S65	1.39	No	No	0	8	8
259	R:R:A284	R:R:F280	1.39	No	No	0	5	8
260	R:R:C187	R:R:Y178	1.34	No	Yes	0	9	6
261	R:R:L197	R:R:Q198	1.33	No	No	0	7	4
262	R:R:R324	R:R:S328	1.32	No	No	0	5	4
263	R:R:R107	R:R:T110	1.29	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.48938	16	1	0
2	R:R:L74	6.004	5	1	9
3	R:R:I85	5.118	5	1	6
4	R:R:M116	5.17	5	1	7
5	R:R:T117	4.1375	4	1	7
6	R:R:F118	7.598	5	0	7
7	R:R:F119	9.11	4	0	8
8	R:R:R134	5.2525	4	3	9
9	R:R:Y135	6.7075	4	0	6
10	R:R:V156	3.07	4	0	4
11	R:R:Y161	6.9825	4	0	7
12	R:R:P171	7.9325	4	1	9
13	R:R:Y178	5.345	4	0	6
14	R:R:Y181	8.2475	4	1	8
15	R:R:T185	4.3375	4	1	8
16	R:R:W186	7.18	6	1	7
17	R:R:F188	4.1925	4	1	8
18	R:R:I189	4.64	4	1	6
19	R:R:Y200	6.6175	4	0	7
20	R:R:I208	3.4375	4	2	8
21	R:R:F273	5.67833	6	2	8
22	R:R:S277	4.005	4	2	9
23	R:R:F283	5.11	4	0	4
24	R:R:L298	6.6875	4	1	6
25	R:R:R302	9.535	4	1	8
26	R:R:N307	6.1425	4	2	9
27	R:R:D311	7.1075	4	0	9
28	R:R:P312	3.3775	4	0	9
29	R:R:V314	1.5225	4	0	8
30	R:R:F315	5.29	5	1	9
31	R:R:P320	6.8125	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y93	10.0036	4.27	Yes	No	1	0	7
2	L:L:?1	R:R:M31	12.2875	9.27	Yes	No	1	0	8
3	R:R:I306	R:R:M31	12.3382	4.37	No	No	0	4	8
4	L:L:?1	R:R:I309	10.2218	6.24	Yes	No	0	0	9
5	L:L:?1	R:R:T123	50.2259	3.22	Yes	No	1	0	8
6	R:R:D78	R:R:T123	50.302	7.23	No	No	1	9	8
7	R:R:D78	R:R:L74	100	9.5	No	Yes	1	9	9
8	R:R:F315	R:R:L74	76.4401	3.65	Yes	Yes	1	9	9
9	R:R:F315	R:R:M269	87.5298	6.22	Yes	No	0	9	9
10	R:R:M269	R:R:V314	44.11	1.52	No	Yes	0	9	8
11	R:R:L318	R:R:V314	15.5053	1.49	No	Yes	0	6	8
12	R:R:L318	R:R:W313	13.602	4.56	No	No	0	6	6
13	L:L:?1	R:R:S308	50.3121	6.57	Yes	No	1	0	8
14	R:R:D78	R:R:S308	50.302	7.36	No	No	1	9	8
15	R:R:C276	R:R:I306	12.2164	4.91	No	No	0	9	4
16	R:R:C276	R:R:N307	12.663	3.15	No	Yes	0	9	9
17	R:R:D311	R:R:N307	30.4522	9.42	Yes	Yes	0	9	9
18	R:R:D311	R:R:P312	39.1463	3.22	Yes	Yes	0	9	9
19	R:R:N39	R:R:P312	14.2567	4.89	No	Yes	0	9	9
20	R:R:L79	R:R:N39	11.4247	6.87	No	No	0	8	9
21	R:R:L127	R:R:L74	26.4884	4.15	No	Yes	0	8	9
22	R:R:D311	R:R:L127	18.0531	12.21	Yes	No	0	9	8
23	R:R:D311	R:R:F315	34.9185	3.58	Yes	Yes	0	9	9
24	R:R:M269	R:R:R134	48.6068	6.2	No	Yes	0	9	9
25	R:R:R134	R:R:V218	24.3922	3.92	Yes	No	0	9	9
26	R:R:I138	R:R:V218	22.7681	4.61	No	No	0	8	9
27	R:R:I138	R:R:S137	13.3533	3.1	No	No	0	8	9
28	R:R:S137	R:R:Y144	11.4399	7.63	No	No	0	9	8
29	L:L:?1	R:R:I85	30.7263	5.2	Yes	Yes	1	0	6
30	R:R:F119	R:R:I85	30.4218	7.54	Yes	Yes	0	8	6
31	R:R:F118	R:R:F119	22.8036	15	Yes	Yes	0	7	8
32	R:R:F118	R:R:Y161	18.449	7.22	Yes	Yes	0	7	7
33	R:R:L157	R:R:Y161	12.389	10.55	No	Yes	0	7	7
34	R:R:L74	R:R:M126	21.5449	5.65	Yes	No	0	9	8
35	R:R:M126	R:R:V156	19.6366	3.04	No	Yes	0	8	4
36	L:L:?1	R:R:M116	38.3292	8.24	Yes	Yes	1	0	7
37	R:R:F188	R:R:M116	33.3503	4.98	Yes	Yes	1	8	7
38	R:R:F188	R:R:I189	30.4116	3.77	Yes	Yes	1	8	6
39	R:R:I189	R:R:Y196	35.756	6.04	Yes	No	1	6	6
40	R:R:P171	R:R:Y196	29.498	19.47	Yes	No	1	9	6
41	R:R:P171	R:R:Y178	16.9416	6.95	Yes	Yes	0	9	6
42	R:R:C187	R:R:Y178	10.2878	1.34	No	Yes	0	9	6
43	R:R:C168	R:R:T117	11.1252	3.38	No	Yes	0	8	7
44	R:R:M116	R:R:S120	20.3979	3.07	Yes	No	0	7	7
45	R:R:S120	R:R:Y200	21.2962	3.82	No	Yes	0	7	7
46	R:R:I160	R:R:V156	13.8507	3.07	No	Yes	0	6	4
47	R:R:I160	R:R:L125	11.9017	7.14	No	No	0	6	6
48	R:R:F273	R:R:N307	11.3841	6.04	Yes	Yes	2	8	9
49	R:R:L304	R:R:S120	31.0816	3	No	No	0	8	7
50	R:R:L304	R:R:S277	30.8938	3	No	Yes	0	8	9
51	R:R:F273	R:R:S277	12.6478	3.96	Yes	Yes	2	8	9
52	R:R:F273	R:R:L127	21.9814	3.65	Yes	No	0	8	8
53	R:R:F273	R:R:V211	29.8381	10.49	Yes	No	0	8	8
54	R:R:A131	R:R:V211	27.407	5.09	No	No	0	9	8
55	R:R:L266	R:R:R134	18.8804	4.86	No	Yes	3	8	9
56	R:R:A131	R:R:C214	24.9657	1.81	No	No	0	9	7
57	R:R:C214	R:R:Y135	20.0528	8.06	No	Yes	0	7	6
58	R:R:L136	R:R:Y135	10.1051	3.52	No	Yes	0	5	6
59	R:R:G176	R:R:P171	11.9677	2.03	No	Yes	0	8	9
60	L:L:?1	R:R:W186	33.3909	6.64	Yes	Yes	1	0	7
61	R:R:P183	R:R:W186	28.8535	9.46	No	Yes	0	8	7
62	R:R:C182	R:R:P183	26.8436	1.88	No	No	0	3	8
63	R:R:L204	R:R:Y200	10.9983	9.38	No	Yes	0	7	7
64	R:R:I219	R:R:L266	17.1497	8.56	No	No	0	7	8
65	R:R:I219	R:R:L263	13.5817	4.28	No	No	0	7	7
66	R:R:I268	R:R:V314	24.3922	1.54	No	Yes	0	5	8
67	R:R:I268	R:R:L265	22.5397	2.85	No	No	0	5	8
68	R:R:L265	R:R:P320	20.6771	3.28	No	Yes	0	8	7
69	R:R:H262	R:R:P320	15.2667	15.25	No	Yes	0	8	7
70	R:R:E258	R:R:H262	13.3634	4.92	No	No	0	6	8
71	R:R:E258	R:R:R324	11.445	13.96	No	No	0	6	5
72	R:R:C182	R:R:R292	24.8236	4.18	No	No	0	3	1
73	R:R:K293	R:R:R292	22.9965	3.71	No	No	0	3	1
74	R:R:E294	R:R:K293	20.9562	2.7	No	No	0	3	3
75	R:R:E294	R:R:W296	12.6935	9.81	No	No	0	3	3
76	R:R:F283	R:R:W296	10.6024	5.01	Yes	No	0	4	3
77	R:R:A42	R:R:P312	16.9365	1.87	No	Yes	0	9	9
78	R:R:A316	R:R:A42	14.1146	1.79	No	No	0	9	9
79	R:R:A316	R:R:L46	11.2825	1.58	No	No	0	9	9
80	R:R:N307	R:R:S277	16.2818	5.96	Yes	Yes	2	9	9
81	R:R:T117	R:R:Y200	13.4802	6.24	Yes	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S28	8.75	1	Yes	No	0	7	0	1
L:L:?1	R:R:M31	9.27	1	Yes	No	0	8	0	1
L:L:?1	R:R:T82	9.67	1	Yes	No	0	8	0	1
L:L:?1	R:R:I85	5.2	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S86	5.47	1	Yes	No	0	8	0	1
L:L:?1	R:R:V89	8.69	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y93	4.27	1	Yes	No	0	7	0	1
L:L:?1	R:R:M116	8.24	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T123	3.22	1	Yes	No	0	8	0	1
L:L:?1	R:R:T185	4.3	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W186	6.64	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L298	6.05	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R302	9.74	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S305	17.51	1	Yes	No	0	8	0	1
L:L:?1	R:R:S308	6.57	1	Yes	No	0	8	0	1
L:L:?1	R:R:I309	6.24	1	Yes	No	0	9	0	1
R:R:P25	R:R:Y93	11.13	0	No	No	5	7	2	1
R:R:I27	R:R:R302	12.53	0	No	Yes	4	8	2	1
R:R:M31	R:R:R302	3.72	1	No	Yes	8	8	1	1
R:R:I306	R:R:M31	4.37	0	No	No	4	8	2	1
R:R:F32	R:R:S86	9.25	0	No	No	8	8	2	1
R:R:G35	R:R:I309	7.05	0	No	No	9	9	2	1
R:R:D78	R:R:T123	7.23	1	No	No	9	8	2	1
R:R:D78	R:R:S308	7.36	1	No	No	9	8	2	1
R:R:F112	R:R:I85	3.77	1	No	Yes	5	6	2	1
R:R:A115	R:R:I85	3.25	0	No	Yes	5	6	2	1
R:R:I85	R:R:M116	5.83	1	Yes	Yes	6	7	1	1
R:R:F119	R:R:I85	7.54	0	Yes	Yes	8	6	2	1
R:R:P87	R:R:S86	3.56	0	No	No	7	8	2	1
R:R:T185	R:R:V89	3.17	1	Yes	No	8	7	1	1
R:R:T185	R:R:Y93	6.24	1	Yes	No	8	7	1	1
R:R:F112	R:R:M116	3.73	1	No	Yes	5	7	2	1
R:R:M116	R:R:S120	3.07	1	Yes	No	7	7	1	2
R:R:F188	R:R:M116	4.98	1	Yes	Yes	8	7	2	1
R:R:S308	R:R:T123	3.2	1	No	No	8	8	1	1
R:R:W186	R:R:Y181	15.43	1	Yes	Yes	7	8	1	2
R:R:F188	R:R:Y181	4.13	1	Yes	Yes	8	8	2	2
R:R:D297	R:R:Y181	6.9	1	No	Yes	6	8	2	2
R:R:P183	R:R:W186	9.46	0	No	Yes	8	7	2	1
R:R:T185	R:R:W186	3.64	1	Yes	Yes	8	7	1	1
R:R:D297	R:R:W186	3.35	1	No	Yes	6	7	2	1
R:R:L298	R:R:W186	4.56	1	Yes	Yes	6	7	1	1
R:R:L298	R:R:Q299	3.99	1	Yes	No	6	4	1	2
R:R:L298	R:R:R302	12.15	1	Yes	Yes	6	8	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7CX4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	239
Number of Links	263
Number of Hubs	31
Number of Links mediated by Hubs	115
Number of Communities	4
Number of Nodes involved in Communities	35
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	44711
Length Of Smallest Path	3
Average Path Length	12.3828
Length of Longest Path	27
Minimum Path Strength	1.505
Average Path Strength	5.62088
Maximum Path Strength	13.625
Minimum Path Correlation	0.7
Average Path Correlation	0.913406
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.1256
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.5247
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • response to ketone • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to progesterone • response to oxygen-containing compound • cell population proliferation • regulation of cell population proliferation • defense response • response to stress • inflammatory response • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to external biotic stimulus • response to nematode • response to biotic stimulus • response to lipopolysaccharide • response to bacterium • response to molecule of bacterial origin • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to nitrogen compound • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GM9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	GM9
Name	Evatanepag
Synonyms	Evatanepag Evatanepag Sodium
Identifier
Formula	C25 H28 N2 O5 S
Molecular Weight	468.565
SMILES
PubChem	9890801
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	63
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43116
Sequence	>7CX4_nogp_Chain_R G E S P A I S S V M F S A G V L G N L I A L A L L A R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N Q T L V A L A P E S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H P Y F Y Q R R V S R S G G L A V L P V I Y A V S L L F C S L P L L D Y G Q Y V Q Y C P G T W C F I R H G R T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M N E T S S R K E K W D L Q A L R F L S I N S I I D P W V F A I L R P P V L R L M R S V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7CX2	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX2 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-	Gs/β1/γ2	2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-		2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7CX4_nogp.zip

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