psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S28	8.75	Yes	No	0	0	7
2	L:L:?1	R:R:M31	9.27	Yes	No	1	0	8
3	L:L:?1	R:R:T82	9.67	Yes	No	0	0	8
4	L:L:?1	R:R:I85	5.2	Yes	Yes	1	0	6
5	L:L:?1	R:R:S86	5.47	Yes	No	0	0	8
6	L:L:?1	R:R:V89	8.69	Yes	No	1	0	7
7	L:L:?1	R:R:Y93	4.27	Yes	No	1	0	7
8	L:L:?1	R:R:M116	8.24	Yes	Yes	1	0	7
9	L:L:?1	R:R:T123	3.22	Yes	No	1	0	8
10	L:L:?1	R:R:T185	4.3	Yes	Yes	1	0	8
11	L:L:?1	R:R:W186	6.64	Yes	Yes	1	0	7
12	L:L:?1	R:R:L298	6.05	Yes	Yes	1	0	6
13	L:L:?1	R:R:R302	9.74	Yes	Yes	1	0	8
14	L:L:?1	R:R:S305	17.51	Yes	No	0	0	8
15	L:L:?1	R:R:S308	6.57	Yes	No	1	0	8
16	L:L:?1	R:R:I309	6.24	Yes	No	0	0	9
17	R:R:P25	R:R:S24	5.34	No	No	0	5	6
18	R:R:P25	R:R:S29	3.56	No	No	0	5	4
19	R:R:P25	R:R:Y93	11.13	No	No	0	5	7
20	R:R:I27	R:R:R302	12.53	No	Yes	0	4	8
21	R:R:M31	R:R:R302	3.72	No	Yes	1	8	8
22	R:R:I306	R:R:M31	4.37	No	No	0	4	8
23	R:R:F32	R:R:S86	9.25	No	No	0	8	8
24	R:R:G35	R:R:I309	7.05	No	No	0	9	9
25	R:R:G38	R:R:L37	3.42	No	No	0	9	5
26	R:R:L79	R:R:N39	6.87	No	No	0	8	9
27	R:R:N39	R:R:P312	4.89	No	Yes	0	9	9
28	R:R:E133	R:R:L66	5.3	No	No	0	9	6
29	R:R:G153	R:R:L66	3.42	No	No	0	7	6
30	R:R:F67	R:R:V71	7.87	No	No	0	8	8
31	R:R:F315	R:R:F67	4.29	Yes	No	0	9	8
32	R:R:E73	R:R:V69	4.28	No	No	0	7	7
33	R:R:L154	R:R:V69	4.47	No	No	0	5	7
34	R:R:L70	R:R:V156	4.47	No	Yes	0	7	4
35	R:R:M130	R:R:V71	3.04	No	No	0	9	8
36	R:R:E73	R:R:L157	10.6	No	No	0	7	7
37	R:R:D78	R:R:L74	9.5	No	Yes	1	9	9
38	R:R:L74	R:R:M126	5.65	Yes	No	0	9	8
39	R:R:L127	R:R:L74	4.15	No	Yes	0	8	9
40	R:R:L74	R:R:M130	7.07	Yes	No	1	9	9
41	R:R:F315	R:R:L74	3.65	Yes	Yes	1	9	9
42	R:R:P312	R:R:V75	3.53	Yes	No	0	9	9
43	R:R:F76	R:R:L80	3.65	No	No	0	6	5
44	R:R:T77	R:R:Y161	7.49	No	Yes	0	9	7
45	R:R:D78	R:R:T123	7.23	No	No	1	9	8
46	R:R:D78	R:R:S308	7.36	No	No	1	9	8
47	R:R:C83	R:R:L79	3.17	No	No	0	7	8
48	R:R:L80	R:R:L84	4.15	No	No	0	5	5
49	R:R:F119	R:R:G81	9.03	Yes	No	0	8	9
50	R:R:F119	R:R:L84	4.87	Yes	No	0	8	5
51	R:R:F112	R:R:I85	3.77	No	Yes	1	5	6
52	R:R:A115	R:R:I85	3.25	No	Yes	0	5	6
53	R:R:I85	R:R:M116	5.83	Yes	Yes	1	6	7
54	R:R:F119	R:R:I85	7.54	Yes	Yes	0	8	6
55	R:R:P87	R:R:S86	3.56	No	No	0	7	8
56	R:R:V88	R:R:Y111	6.31	No	No	0	5	6
57	R:R:F112	R:R:V88	5.24	No	No	0	5	5
58	R:R:T185	R:R:V89	3.17	Yes	No	1	8	7
59	R:R:T185	R:R:Y93	6.24	Yes	No	1	8	7
60	R:R:L99	R:R:N96	6.87	No	No	0	4	5
61	R:R:N96	R:R:V100	8.87	No	No	0	5	3
62	R:R:L99	R:R:Q97	5.32	No	No	0	4	3
63	R:R:A103	R:R:V100	3.39	No	No	0	5	3
64	R:R:A101	R:R:Q180	4.55	No	No	0	3	4
65	R:R:C109	R:R:L102	6.35	No	No	0	9	3
66	R:R:C109	R:R:C187	7.28	No	No	0	9	9
67	R:R:T110	R:R:Y178	3.75	No	Yes	0	4	6
68	R:R:F112	R:R:M116	3.73	No	Yes	1	5	7
69	R:R:A113	R:R:Y178	9.34	No	Yes	0	7	6
70	R:R:C168	R:R:F114	4.19	No	No	0	8	7
71	R:R:M116	R:R:S120	3.07	Yes	No	0	7	7
72	R:R:F188	R:R:M116	4.98	Yes	Yes	1	8	7
73	R:R:C168	R:R:T117	3.38	No	Yes	0	8	7
74	R:R:F188	R:R:T117	3.89	Yes	Yes	1	8	7
75	R:R:I189	R:R:T117	3.04	Yes	Yes	1	6	7
76	R:R:T117	R:R:Y200	6.24	Yes	Yes	0	7	7
77	R:R:F118	R:R:F119	15	Yes	Yes	0	7	8
78	R:R:F118	R:R:Y161	7.22	Yes	Yes	0	7	7
79	R:R:F118	R:R:S164	7.93	Yes	No	0	7	7
80	R:R:F118	R:R:L165	3.65	Yes	No	0	7	4
81	R:R:C168	R:R:F118	4.19	No	Yes	0	8	7
82	R:R:S120	R:R:Y200	3.82	No	Yes	0	7	7
83	R:R:F167	R:R:L121	3.65	No	No	0	6	7
84	R:R:L121	R:R:Y200	7.03	No	Yes	0	7	7
85	R:R:S308	R:R:T123	3.2	No	No	1	8	8
86	R:R:L207	R:R:M124	4.24	No	No	0	7	7
87	R:R:I160	R:R:L125	7.14	No	No	0	6	6
88	R:R:L125	R:R:L207	5.54	No	No	0	6	7
89	R:R:M126	R:R:V156	3.04	No	Yes	0	8	4
90	R:R:F273	R:R:L127	3.65	Yes	No	0	8	8
91	R:R:D311	R:R:L127	12.21	Yes	No	0	9	8
92	R:R:F128	R:R:L207	3.65	No	No	0	6	7
93	R:R:F128	R:R:S210	6.61	No	No	0	6	5
94	R:R:F315	R:R:M130	8.71	Yes	No	1	9	9
95	R:R:A131	R:R:V211	5.09	No	No	0	9	8
96	R:R:E133	R:R:Y144	6.73	No	No	0	9	8
97	R:R:N215	R:R:R134	6.03	No	Yes	3	9	9
98	R:R:R134	R:R:V218	3.92	Yes	No	0	9	9
99	R:R:L266	R:R:R134	4.86	No	Yes	3	8	9
100	R:R:M269	R:R:R134	6.2	No	Yes	0	9	9
101	R:R:L136	R:R:Y135	3.52	No	Yes	0	5	6
102	R:R:H140	R:R:Y135	7.62	No	Yes	0	5	6
103	R:R:C214	R:R:Y135	8.06	No	Yes	0	7	6
104	R:R:S217	R:R:Y135	7.63	No	Yes	0	6	6
105	R:R:F143	R:R:L136	3.65	No	No	0	4	5
106	R:R:I138	R:R:S137	3.1	No	No	0	8	9
107	R:R:S137	R:R:Y144	7.63	No	No	0	9	8
108	R:R:I138	R:R:V218	4.61	No	No	0	8	9
109	R:R:G139	R:R:N221	3.39	No	No	0	7	6
110	R:R:F143	R:R:R147	3.21	No	No	0	4	4
111	R:R:V148	R:R:Y144	12.62	No	No	0	5	8
112	R:R:R146	R:R:R147	3.2	No	No	0	5	4
113	R:R:I160	R:R:V156	3.07	No	Yes	0	6	4
114	R:R:L157	R:R:P158	6.57	No	No	0	7	3
115	R:R:L157	R:R:Y161	10.55	No	Yes	0	7	7
116	R:R:F167	R:R:L203	4.87	No	No	0	6	5
117	R:R:L170	R:R:P171	3.28	No	Yes	1	7	9
118	R:R:L170	R:R:Y175	4.69	No	No	0	7	4
119	R:R:L170	R:R:Y196	4.69	No	No	1	7	6
120	R:R:P171	R:R:Y178	6.95	Yes	Yes	0	9	6
121	R:R:P171	R:R:Y196	19.47	Yes	No	1	9	6
122	R:R:L173	R:R:Y175	7.03	No	No	0	3	4
123	R:R:G176	R:R:T194	3.64	No	No	0	8	3
124	R:R:Q177	R:R:R190	16.35	No	No	0	3	5
125	R:R:R190	R:R:V179	7.85	No	No	0	5	4
126	R:R:G184	R:R:Q180	4.93	No	No	0	5	4
127	R:R:W186	R:R:Y181	15.43	Yes	Yes	1	7	8
128	R:R:F188	R:R:Y181	4.13	Yes	Yes	1	8	8
129	R:R:H191	R:R:Y181	6.53	No	Yes	0	6	8
130	R:R:D297	R:R:Y181	6.9	No	Yes	1	6	8
131	R:R:C182	R:R:R292	4.18	No	No	0	3	1
132	R:R:P183	R:R:W186	9.46	No	Yes	0	8	7
133	R:R:T185	R:R:W186	3.64	Yes	Yes	1	8	7
134	R:R:D297	R:R:W186	3.35	No	Yes	1	6	7
135	R:R:L298	R:R:W186	4.56	Yes	Yes	1	6	7
136	R:R:F188	R:R:I189	3.77	Yes	Yes	1	8	6
137	R:R:I189	R:R:Y196	6.04	Yes	No	1	6	6
138	R:R:I189	R:R:L197	5.71	Yes	No	0	6	7
139	R:R:R190	R:R:R193	4.26	No	No	0	5	5
140	R:R:H191	R:R:L197	6.43	No	No	0	6	7
141	R:R:E288	R:R:H191	6.15	No	No	0	5	6
142	R:R:L204	R:R:Y200	9.38	No	Yes	0	7	7
143	R:R:A201	R:R:Y285	5.34	No	No	0	7	5
144	R:R:T202	R:R:Y285	3.75	No	No	0	4	5
145	R:R:L205	R:R:T281	7.37	No	No	0	6	7
146	R:R:F273	R:R:I208	6.28	Yes	Yes	2	8	8
147	R:R:I208	R:R:S277	3.1	Yes	Yes	2	8	9
148	R:R:F273	R:R:V211	10.49	Yes	No	0	8	8
149	R:R:F273	R:R:L212	3.65	Yes	No	0	8	7
150	R:R:A274	R:R:L212	4.73	No	No	0	6	7
151	R:R:L266	R:R:N215	4.12	No	No	3	8	9
152	R:R:N215	R:R:T270	7.31	No	No	0	9	8
153	R:R:F216	R:R:T270	3.89	No	No	0	5	8
154	R:R:I219	R:R:L263	4.28	No	No	0	7	7
155	R:R:I219	R:R:L266	8.56	No	No	0	7	8
156	R:R:N221	R:R:R224	3.62	No	No	0	6	5
157	R:R:L222	R:R:L263	4.15	No	No	0	8	7
158	R:R:I223	R:R:L263	5.71	No	No	0	5	7
159	R:R:E259	R:R:M225	4.06	No	No	0	8	7
160	R:R:E259	R:R:H226	9.85	No	No	0	8	5
161	R:R:E258	R:R:H262	4.92	No	No	0	6	8
162	R:R:E258	R:R:R324	13.96	No	No	0	6	5
163	R:R:D261	R:R:T260	4.34	No	No	0	8	5
164	R:R:D261	R:R:L323	4.07	No	No	0	8	7
165	R:R:D261	R:R:R324	8.34	No	No	0	8	5
166	R:R:H262	R:R:P320	15.25	No	Yes	0	8	7
167	R:R:I264	R:R:L323	8.56	No	No	0	6	7
168	R:R:L265	R:R:P320	3.28	No	Yes	0	8	7
169	R:R:F315	R:R:M269	6.22	Yes	No	0	9	9
170	R:R:I310	R:R:T272	3.04	No	No	0	7	7
171	R:R:F273	R:R:S277	3.96	Yes	Yes	2	8	9
172	R:R:F273	R:R:N307	6.04	Yes	Yes	2	8	9
173	R:R:C276	R:R:V275	3.42	No	No	0	9	5
174	R:R:C276	R:R:I306	4.91	No	No	0	9	4
175	R:R:C276	R:R:N307	3.15	No	Yes	0	9	9
176	R:R:N307	R:R:S277	5.96	Yes	Yes	2	9	9
177	R:R:F303	R:R:P279	8.67	No	No	0	6	9
178	R:R:F283	R:R:I282	7.54	Yes	No	0	4	6
179	R:R:F283	R:R:M286	3.73	Yes	No	0	4	4
180	R:R:F283	R:R:W296	5.01	Yes	No	0	4	3
181	R:R:A300	R:R:F283	4.16	No	Yes	0	7	4
182	R:R:N287	R:R:T289	5.85	No	No	0	6	3
183	R:R:N287	R:R:S290	5.96	No	No	0	6	2
184	R:R:E294	R:R:S290	10.06	No	No	0	3	2
185	R:R:K293	R:R:R292	3.71	No	No	0	3	1
186	R:R:E294	R:R:W296	9.81	No	No	0	3	3
187	R:R:L298	R:R:Q299	3.99	Yes	No	0	6	4
188	R:R:L298	R:R:R302	12.15	Yes	Yes	1	6	8
189	R:R:D311	R:R:N307	9.42	Yes	Yes	0	9	9
190	R:R:D311	R:R:P312	3.22	Yes	Yes	0	9	9
191	R:R:D311	R:R:F315	3.58	Yes	Yes	0	9	9
192	R:R:I317	R:R:W313	4.7	No	No	0	8	6
193	R:R:L318	R:R:W313	4.56	No	No	0	6	6
194	R:R:P320	R:R:P321	5.84	Yes	No	0	7	7
195	R:R:L330	R:R:R327	9.72	No	No	0	5	3
196	R:R:A257	R:R:E259	3.02	No	No	0	5	8
197	R:R:L304	R:R:S120	3	No	No	0	8	7
198	R:R:G192	R:R:R193	3	No	No	0	3	5
199	R:R:L304	R:R:S277	3	No	Yes	0	8	9
200	R:R:L40	R:R:V36	2.98	No	No	0	5	7
201	R:R:L205	R:R:V209	2.98	No	No	0	6	4
202	R:R:L46	R:R:T72	2.95	No	No	0	9	5
203	R:R:I317	R:R:I41	2.94	No	No	4	8	5
204	R:R:P320	R:R:R319	2.88	Yes	No	0	7	9
205	R:R:I208	R:R:L278	2.85	Yes	No	0	8	6
206	R:R:I268	R:R:L265	2.85	No	No	0	5	8
207	R:R:I138	R:R:N221	2.83	No	No	0	8	6
208	R:R:L222	R:R:M225	2.83	No	No	0	8	7
209	R:R:G38	R:R:W313	2.81	No	No	0	9	6
210	R:R:L40	R:R:L79	2.77	No	No	0	5	8
211	R:R:A103	R:R:R95	2.77	No	No	0	5	4
212	R:R:E294	R:R:K293	2.7	No	No	0	3	3
213	R:R:A122	R:R:Y161	2.67	No	Yes	0	7	7
214	R:R:L102	R:R:Q180	2.66	No	No	0	3	4
215	R:R:R150	R:R:V69	2.62	No	No	0	4	7
216	R:R:H68	R:R:L46	2.57	No	No	0	8	9
217	R:R:F303	R:R:I306	2.51	No	No	0	6	4
218	R:R:F32	R:R:L90	2.44	No	No	0	8	7
219	R:R:F114	R:R:L172	2.44	No	No	0	7	4
220	R:R:F280	R:R:L204	2.44	No	No	0	8	7
221	R:R:F280	R:R:L301	2.44	No	No	0	8	7
222	R:R:L220	R:R:R224	2.43	No	No	0	3	5
223	R:R:G152	R:R:G153	2.11	No	No	0	5	7
224	R:R:G176	R:R:P171	2.03	No	Yes	0	8	9
225	R:R:A34	R:R:G35	1.95	No	No	0	6	9
226	R:R:C182	R:R:P183	1.88	No	No	0	3	8
227	R:R:A42	R:R:P312	1.87	No	Yes	0	9	9
228	R:R:A103	R:R:P104	1.87	No	No	0	5	3
229	R:R:A131	R:R:C214	1.81	No	No	0	9	7
230	R:R:A316	R:R:A42	1.79	No	No	0	9	9
231	R:R:A201	R:R:A284	1.79	No	No	0	7	5
232	R:R:A26	R:R:S24	1.71	No	No	0	4	6
233	R:R:A34	R:R:S33	1.71	No	No	0	6	5
234	R:R:A129	R:R:V156	1.7	No	Yes	0	7	4
235	R:R:G22	R:R:Q97	1.64	No	No	0	2	3
236	R:R:G176	R:R:Q177	1.64	No	No	0	8	3
237	R:R:S33	R:R:V30	1.62	No	No	0	5	5
238	R:R:A267	R:R:I219	1.62	No	No	0	5	7
239	R:R:C214	R:R:L132	1.59	No	No	0	7	6
240	R:R:A44	R:R:L45	1.58	No	No	0	4	7
241	R:R:A316	R:R:L46	1.58	No	No	0	9	9
242	R:R:E105	R:R:P104	1.57	No	No	0	4	3
243	R:R:I268	R:R:V314	1.54	No	Yes	0	5	8
244	R:R:I310	R:R:V314	1.54	No	Yes	0	7	8
245	R:R:H140	R:R:P141	1.53	No	No	0	5	9
246	R:R:M286	R:R:S291	1.53	No	No	0	4	1
247	R:R:I208	R:R:T281	1.52	Yes	No	0	8	7
248	R:R:M269	R:R:V314	1.52	No	Yes	0	9	8
249	R:R:A108	R:R:E105	1.51	No	No	0	5	4
250	R:R:L43	R:R:V75	1.49	No	No	0	8	9
251	R:R:L125	R:R:V163	1.49	No	No	0	6	3
252	R:R:L318	R:R:V314	1.49	No	Yes	0	6	8
253	R:R:L99	R:R:T98	1.47	No	No	0	4	4
254	R:R:L199	R:R:T202	1.47	No	No	0	5	4
255	R:R:I41	R:R:L45	1.43	No	No	4	5	7
256	R:R:I317	R:R:L45	1.43	No	No	4	8	7
257	R:R:L330	R:R:M326	1.41	No	No	0	5	4
258	R:R:H68	R:R:S65	1.39	No	No	0	8	8
259	R:R:A284	R:R:F280	1.39	No	No	0	5	8
260	R:R:C187	R:R:Y178	1.34	No	Yes	0	9	6
261	R:R:L197	R:R:Q198	1.33	No	No	0	7	4
262	R:R:R324	R:R:S328	1.32	No	No	0	5	4
263	R:R:R107	R:R:T110	1.29	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.48938	16	1	0
2	R:R:L74	6.004	5	1	9
3	R:R:I85	5.118	5	1	6
4	R:R:M116	5.17	5	1	7
5	R:R:T117	4.1375	4	1	7
6	R:R:F118	7.598	5	0	7
7	R:R:F119	9.11	4	0	8
8	R:R:R134	5.2525	4	3	9
9	R:R:Y135	6.7075	4	0	6
10	R:R:V156	3.07	4	0	4
11	R:R:Y161	6.9825	4	0	7
12	R:R:P171	7.9325	4	1	9
13	R:R:Y178	5.345	4	0	6
14	R:R:Y181	8.2475	4	1	8
15	R:R:T185	4.3375	4	1	8
16	R:R:W186	7.18	6	1	7
17	R:R:F188	4.1925	4	1	8
18	R:R:I189	4.64	4	1	6
19	R:R:Y200	6.6175	4	0	7
20	R:R:I208	3.4375	4	2	8
21	R:R:F273	5.67833	6	2	8
22	R:R:S277	4.005	4	2	9
23	R:R:F283	5.11	4	0	4
24	R:R:L298	6.6875	4	1	6
25	R:R:R302	9.535	4	1	8
26	R:R:N307	6.1425	4	2	9
27	R:R:D311	7.1075	4	0	9
28	R:R:P312	3.3775	4	0	9
29	R:R:V314	1.5225	4	0	8
30	R:R:F315	5.29	5	1	9
31	R:R:P320	6.8125	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y93	10.0036	4.27	Yes	No	1	0	7
2	L:L:?1	R:R:M31	12.2875	9.27	Yes	No	1	0	8
3	R:R:I306	R:R:M31	12.3382	4.37	No	No	0	4	8
4	L:L:?1	R:R:I309	10.2218	6.24	Yes	No	0	0	9
5	L:L:?1	R:R:T123	50.2259	3.22	Yes	No	1	0	8
6	R:R:D78	R:R:T123	50.302	7.23	No	No	1	9	8
7	R:R:D78	R:R:L74	100	9.5	No	Yes	1	9	9
8	R:R:F315	R:R:L74	76.4401	3.65	Yes	Yes	1	9	9
9	R:R:F315	R:R:M269	87.5298	6.22	Yes	No	0	9	9
10	R:R:M269	R:R:V314	44.11	1.52	No	Yes	0	9	8
11	R:R:L318	R:R:V314	15.5053	1.49	No	Yes	0	6	8
12	R:R:L318	R:R:W313	13.602	4.56	No	No	0	6	6
13	L:L:?1	R:R:S308	50.3121	6.57	Yes	No	1	0	8
14	R:R:D78	R:R:S308	50.302	7.36	No	No	1	9	8
15	R:R:C276	R:R:I306	12.2164	4.91	No	No	0	9	4
16	R:R:C276	R:R:N307	12.663	3.15	No	Yes	0	9	9
17	R:R:D311	R:R:N307	30.4522	9.42	Yes	Yes	0	9	9
18	R:R:D311	R:R:P312	39.1463	3.22	Yes	Yes	0	9	9
19	R:R:N39	R:R:P312	14.2567	4.89	No	Yes	0	9	9
20	R:R:L79	R:R:N39	11.4247	6.87	No	No	0	8	9
21	R:R:L127	R:R:L74	26.4884	4.15	No	Yes	0	8	9
22	R:R:D311	R:R:L127	18.0531	12.21	Yes	No	0	9	8
23	R:R:D311	R:R:F315	34.9185	3.58	Yes	Yes	0	9	9
24	R:R:M269	R:R:R134	48.6068	6.2	No	Yes	0	9	9
25	R:R:R134	R:R:V218	24.3922	3.92	Yes	No	0	9	9
26	R:R:I138	R:R:V218	22.7681	4.61	No	No	0	8	9
27	R:R:I138	R:R:S137	13.3533	3.1	No	No	0	8	9
28	R:R:S137	R:R:Y144	11.4399	7.63	No	No	0	9	8
29	L:L:?1	R:R:I85	30.7263	5.2	Yes	Yes	1	0	6
30	R:R:F119	R:R:I85	30.4218	7.54	Yes	Yes	0	8	6
31	R:R:F118	R:R:F119	22.8036	15	Yes	Yes	0	7	8
32	R:R:F118	R:R:Y161	18.449	7.22	Yes	Yes	0	7	7
33	R:R:L157	R:R:Y161	12.389	10.55	No	Yes	0	7	7
34	R:R:L74	R:R:M126	21.5449	5.65	Yes	No	0	9	8
35	R:R:M126	R:R:V156	19.6366	3.04	No	Yes	0	8	4
36	L:L:?1	R:R:M116	38.3292	8.24	Yes	Yes	1	0	7
37	R:R:F188	R:R:M116	33.3503	4.98	Yes	Yes	1	8	7
38	R:R:F188	R:R:I189	30.4116	3.77	Yes	Yes	1	8	6
39	R:R:I189	R:R:Y196	35.756	6.04	Yes	No	1	6	6
40	R:R:P171	R:R:Y196	29.498	19.47	Yes	No	1	9	6
41	R:R:P171	R:R:Y178	16.9416	6.95	Yes	Yes	0	9	6
42	R:R:C187	R:R:Y178	10.2878	1.34	No	Yes	0	9	6
43	R:R:C168	R:R:T117	11.1252	3.38	No	Yes	0	8	7
44	R:R:M116	R:R:S120	20.3979	3.07	Yes	No	0	7	7
45	R:R:S120	R:R:Y200	21.2962	3.82	No	Yes	0	7	7
46	R:R:I160	R:R:V156	13.8507	3.07	No	Yes	0	6	4
47	R:R:I160	R:R:L125	11.9017	7.14	No	No	0	6	6
48	R:R:F273	R:R:N307	11.3841	6.04	Yes	Yes	2	8	9
49	R:R:L304	R:R:S120	31.0816	3	No	No	0	8	7
50	R:R:L304	R:R:S277	30.8938	3	No	Yes	0	8	9
51	R:R:F273	R:R:S277	12.6478	3.96	Yes	Yes	2	8	9
52	R:R:F273	R:R:L127	21.9814	3.65	Yes	No	0	8	8
53	R:R:F273	R:R:V211	29.8381	10.49	Yes	No	0	8	8
54	R:R:A131	R:R:V211	27.407	5.09	No	No	0	9	8
55	R:R:L266	R:R:R134	18.8804	4.86	No	Yes	3	8	9
56	R:R:A131	R:R:C214	24.9657	1.81	No	No	0	9	7
57	R:R:C214	R:R:Y135	20.0528	8.06	No	Yes	0	7	6
58	R:R:L136	R:R:Y135	10.1051	3.52	No	Yes	0	5	6
59	R:R:G176	R:R:P171	11.9677	2.03	No	Yes	0	8	9
60	L:L:?1	R:R:W186	33.3909	6.64	Yes	Yes	1	0	7
61	R:R:P183	R:R:W186	28.8535	9.46	No	Yes	0	8	7
62	R:R:C182	R:R:P183	26.8436	1.88	No	No	0	3	8
63	R:R:L204	R:R:Y200	10.9983	9.38	No	Yes	0	7	7
64	R:R:I219	R:R:L266	17.1497	8.56	No	No	0	7	8
65	R:R:I219	R:R:L263	13.5817	4.28	No	No	0	7	7
66	R:R:I268	R:R:V314	24.3922	1.54	No	Yes	0	5	8
67	R:R:I268	R:R:L265	22.5397	2.85	No	No	0	5	8
68	R:R:L265	R:R:P320	20.6771	3.28	No	Yes	0	8	7
69	R:R:H262	R:R:P320	15.2667	15.25	No	Yes	0	8	7
70	R:R:E258	R:R:H262	13.3634	4.92	No	No	0	6	8
71	R:R:E258	R:R:R324	11.445	13.96	No	No	0	6	5
72	R:R:C182	R:R:R292	24.8236	4.18	No	No	0	3	1
73	R:R:K293	R:R:R292	22.9965	3.71	No	No	0	3	1
74	R:R:E294	R:R:K293	20.9562	2.7	No	No	0	3	3
75	R:R:E294	R:R:W296	12.6935	9.81	No	No	0	3	3
76	R:R:F283	R:R:W296	10.6024	5.01	Yes	No	0	4	3
77	R:R:A42	R:R:P312	16.9365	1.87	No	Yes	0	9	9
78	R:R:A316	R:R:A42	14.1146	1.79	No	No	0	9	9
79	R:R:A316	R:R:L46	11.2825	1.58	No	No	0	9	9
80	R:R:N307	R:R:S277	16.2818	5.96	Yes	Yes	2	9	9
81	R:R:T117	R:R:Y200	13.4802	6.24	Yes	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S28	8.75	1	Yes	No	0	7	0	1
L:L:?1	R:R:M31	9.27	1	Yes	No	0	8	0	1
L:L:?1	R:R:T82	9.67	1	Yes	No	0	8	0	1
L:L:?1	R:R:I85	5.2	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S86	5.47	1	Yes	No	0	8	0	1
L:L:?1	R:R:V89	8.69	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y93	4.27	1	Yes	No	0	7	0	1
L:L:?1	R:R:M116	8.24	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T123	3.22	1	Yes	No	0	8	0	1
L:L:?1	R:R:T185	4.3	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W186	6.64	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L298	6.05	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R302	9.74	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S305	17.51	1	Yes	No	0	8	0	1
L:L:?1	R:R:S308	6.57	1	Yes	No	0	8	0	1
L:L:?1	R:R:I309	6.24	1	Yes	No	0	9	0	1
R:R:P25	R:R:Y93	11.13	0	No	No	5	7	2	1
R:R:I27	R:R:R302	12.53	0	No	Yes	4	8	2	1
R:R:M31	R:R:R302	3.72	1	No	Yes	8	8	1	1
R:R:I306	R:R:M31	4.37	0	No	No	4	8	2	1
R:R:F32	R:R:S86	9.25	0	No	No	8	8	2	1
R:R:G35	R:R:I309	7.05	0	No	No	9	9	2	1
R:R:D78	R:R:T123	7.23	1	No	No	9	8	2	1
R:R:D78	R:R:S308	7.36	1	No	No	9	8	2	1
R:R:F112	R:R:I85	3.77	1	No	Yes	5	6	2	1
R:R:A115	R:R:I85	3.25	0	No	Yes	5	6	2	1
R:R:I85	R:R:M116	5.83	1	Yes	Yes	6	7	1	1
R:R:F119	R:R:I85	7.54	0	Yes	Yes	8	6	2	1
R:R:P87	R:R:S86	3.56	0	No	No	7	8	2	1
R:R:T185	R:R:V89	3.17	1	Yes	No	8	7	1	1
R:R:T185	R:R:Y93	6.24	1	Yes	No	8	7	1	1
R:R:F112	R:R:M116	3.73	1	No	Yes	5	7	2	1
R:R:M116	R:R:S120	3.07	1	Yes	No	7	7	1	2
R:R:F188	R:R:M116	4.98	1	Yes	Yes	8	7	2	1
R:R:S308	R:R:T123	3.2	1	No	No	8	8	1	1
R:R:W186	R:R:Y181	15.43	1	Yes	Yes	7	8	1	2
R:R:F188	R:R:Y181	4.13	1	Yes	Yes	8	8	2	2
R:R:D297	R:R:Y181	6.9	1	No	Yes	6	8	2	2
R:R:P183	R:R:W186	9.46	0	No	Yes	8	7	2	1
R:R:T185	R:R:W186	3.64	1	Yes	Yes	8	7	1	1
R:R:D297	R:R:W186	3.35	1	No	Yes	6	7	2	1
R:R:L298	R:R:W186	4.56	1	Yes	Yes	6	7	1	1
R:R:L298	R:R:Q299	3.99	1	Yes	No	6	4	1	2
R:R:L298	R:R:R302	12.15	1	Yes	Yes	6	8	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7CX4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	239
Number of Links	263
Number of Hubs	31
Number of Links mediated by Hubs	115
Number of Communities	4
Number of Nodes involved in Communities	35
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	44711
Length Of Smallest Path	3
Average Path Length	12.3828
Length of Longest Path	27
Minimum Path Strength	1.505
Average Path Strength	5.62088
Maximum Path Strength	13.625
Minimum Path Correlation	0.7
Average Path Correlation	0.913406
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.1256
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.5247
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GM9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	GM9
Name	Evatanepag
Synonyms	Evatanepag Sodium Evatanepag
Identifier
Formula	C25 H28 N2 O5 S
Molecular Weight	468.565
SMILES
PubChem	9890801
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	63
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43116
Sequence	>7CX4_nogp_Chain_R G E S P A I S S V M F S A G V L G N L I A L A L L A R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N Q T L V A L A P E S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H P Y F Y Q R R V S R S G G L A V L P V I Y A V S L L F C S L P L L D Y G Q Y V Q Y C P G T W C F I R H G R T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M N E T S S R K E K W D L Q A L R F L S I N S I I D P W V F A I L R P P V L R L M R S V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7CX2	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX2 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-	Gs/β1/γ2	2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-		2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268
	9JRO	A	Lipid	Prostanoid	EP₂	Homo sapiens	PF-04418948	-	-	3.5	2025-10-22	To be published
	9JRT	A	Lipid	Prostanoid	EP₂	Homo sapiens	TG6-129	-	-	3.28	2025-10-22	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7CX4_nogp.zip

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