psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P25	R:R:S24	3.56	No	No	0	5	6
2	R:R:P25	R:R:S29	5.34	No	No	0	5	4
3	R:R:P25	R:R:Y93	9.74	No	No	0	5	7
4	R:R:I27	R:R:R302	7.52	No	Yes	0	4	8
5	R:R:R302	R:R:S28	3.95	Yes	No	1	8	7
6	L:L:?1	R:R:S28	7.97	Yes	No	1	0	7
7	R:R:L90	R:R:S29	4.5	No	No	0	7	4
8	R:R:M31	R:R:R302	3.72	No	Yes	1	8	8
9	L:L:?1	R:R:M31	4.69	Yes	No	1	0	8
10	R:R:F32	R:R:V36	3.93	Yes	No	1	8	7
11	R:R:F32	R:R:T82	9.08	Yes	No	1	8	8
12	R:R:F32	R:R:S86	17.18	Yes	No	1	8	8
13	L:L:?1	R:R:F32	4.04	Yes	Yes	1	0	8
14	R:R:G35	R:R:I309	7.05	No	No	0	9	9
15	R:R:T82	R:R:V36	4.76	No	No	1	8	7
16	R:R:L79	R:R:N39	4.12	No	No	0	8	9
17	R:R:N39	R:R:P312	6.52	No	Yes	0	9	9
18	R:R:L40	R:R:L79	4.15	No	No	0	5	8
19	R:R:L46	R:R:V71	4.47	No	No	0	9	8
20	R:R:L46	R:R:T72	5.9	No	No	0	9	5
21	R:R:L46	R:R:V75	4.47	No	No	0	9	9
22	R:R:L66	R:R:L70	5.54	No	No	2	6	7
23	R:R:E133	R:R:L66	6.63	No	No	2	9	6
24	R:R:L66	R:R:Y144	3.52	No	Yes	2	6	8
25	R:R:F315	R:R:F67	3.22	Yes	No	0	9	8
26	R:R:F67	R:R:R319	5.34	No	No	0	8	9
27	R:R:L154	R:R:V69	4.47	No	Yes	0	5	7
28	R:R:L70	R:R:M130	4.24	No	No	2	7	9
29	R:R:E133	R:R:L70	5.3	No	No	2	9	7
30	R:R:E73	R:R:L157	7.95	No	Yes	0	7	7
31	R:R:D78	R:R:L74	5.43	Yes	Yes	0	9	9
32	R:R:L74	R:R:M126	5.65	Yes	No	0	9	8
33	R:R:L74	R:R:M130	5.65	Yes	No	2	9	9
34	R:R:F315	R:R:L74	3.65	Yes	Yes	2	9	9
35	R:R:P312	R:R:V75	3.53	Yes	No	0	9	9
36	R:R:F76	R:R:L157	6.09	No	Yes	4	6	7
37	R:R:F76	R:R:Y161	6.19	No	Yes	4	6	7
38	R:R:T77	R:R:Y161	6.24	No	Yes	0	9	7
39	R:R:D78	R:R:T123	5.78	Yes	No	0	9	8
40	R:R:D78	R:R:S308	7.36	Yes	No	0	9	8
41	R:R:D78	R:R:P312	6.44	Yes	Yes	0	9	9
42	R:R:G81	R:R:L80	3.42	No	No	0	9	5
43	R:R:L80	R:R:L84	5.54	No	No	0	5	5
44	R:R:F119	R:R:G81	10.54	Yes	No	0	8	9
45	L:L:?1	R:R:T82	7.83	Yes	No	1	0	8
46	R:R:A115	R:R:I85	3.25	No	No	1	5	6
47	R:R:F119	R:R:I85	5.02	Yes	No	1	8	6
48	L:L:?1	R:R:I85	7.58	Yes	No	1	0	6
49	L:L:?1	R:R:S86	6.98	Yes	No	1	0	8
50	R:R:F112	R:R:V88	5.24	No	No	0	5	5
51	R:R:F112	R:R:V89	3.93	No	No	0	5	7
52	L:L:?1	R:R:V89	7.91	Yes	No	0	0	7
53	L:L:?1	R:R:Y93	3.89	Yes	No	0	0	7
54	R:R:N96	R:R:V100	4.43	No	No	0	5	3
55	R:R:A103	R:R:N96	4.69	No	No	0	5	5
56	R:R:A103	R:R:P104	3.74	No	No	0	5	3
57	R:R:A108	R:R:P104	3.74	No	No	0	5	3
58	R:R:C109	R:R:C187	7.28	No	No	0	9	9
59	R:R:T110	R:R:Y178	4.99	No	Yes	0	4	6
60	R:R:F112	R:R:M116	3.73	No	No	0	5	7
61	R:R:A113	R:R:Y178	9.34	No	Yes	0	7	6
62	R:R:F114	R:R:S169	5.28	No	No	0	7	5
63	R:R:F114	R:R:L172	4.87	No	No	3	7	4
64	R:R:F114	R:R:Y178	5.16	No	Yes	3	7	6
65	R:R:A115	R:R:F119	4.16	No	Yes	1	5	8
66	R:R:F188	R:R:M116	3.73	Yes	No	0	8	7
67	L:L:?1	R:R:M116	6.57	Yes	No	0	0	7
68	R:R:C168	R:R:T117	6.76	No	No	0	8	7
69	R:R:F188	R:R:T117	3.89	Yes	No	0	8	7
70	R:R:T117	R:R:Y200	7.49	No	Yes	0	7	7
71	R:R:F118	R:R:F119	7.5	Yes	Yes	0	7	8
72	R:R:F118	R:R:Y161	6.19	Yes	Yes	0	7	7
73	R:R:F118	R:R:S164	7.93	Yes	No	0	7	7
74	R:R:F118	R:R:L165	8.53	Yes	No	0	7	4
75	L:L:?1	R:R:F119	4.04	Yes	Yes	1	0	8
76	R:R:F167	R:R:L121	3.65	No	No	0	6	7
77	R:R:L121	R:R:Y200	8.21	No	Yes	0	7	7
78	L:L:?1	R:R:T123	3.91	Yes	No	0	0	8
79	R:R:L204	R:R:M124	5.65	No	No	0	7	7
80	R:R:L207	R:R:M124	5.65	No	No	0	7	7
81	R:R:I160	R:R:L125	12.85	No	No	0	6	6
82	R:R:L125	R:R:L207	5.54	No	No	0	6	7
83	R:R:I160	R:R:M126	5.83	No	No	0	6	8
84	R:R:D311	R:R:L127	10.86	No	No	0	9	8
85	R:R:F128	R:R:L207	4.87	No	No	0	6	7
86	R:R:F128	R:R:S210	3.96	No	No	0	6	5
87	R:R:F315	R:R:M130	9.95	Yes	No	2	9	9
88	R:R:A131	R:R:V211	3.39	No	No	0	9	8
89	R:R:E133	R:R:Y144	7.86	No	Yes	2	9	8
90	R:R:N215	R:R:R134	6.03	No	No	0	9	9
91	R:R:L266	R:R:R134	3.64	No	No	0	8	9
92	R:R:M269	R:R:R134	4.96	No	No	0	9	9
93	R:R:L136	R:R:Y135	3.52	No	Yes	5	5	6
94	R:R:H140	R:R:Y135	9.8	No	Yes	5	5	6
95	R:R:S217	R:R:Y135	6.36	No	Yes	0	6	6
96	R:R:H140	R:R:L136	3.86	No	No	5	5	5
97	R:R:F143	R:R:L136	3.65	No	No	0	4	5
98	R:R:S137	R:R:Y144	7.63	No	Yes	0	9	8
99	R:R:I138	R:R:V218	4.61	No	No	0	8	9
100	R:R:G139	R:R:N221	5.09	No	No	0	7	6
101	R:R:F143	R:R:R147	5.34	No	No	0	4	4
102	R:R:V148	R:R:Y144	13.88	No	Yes	0	5	8
103	R:R:R146	R:R:R147	12.79	No	No	0	5	4
104	R:R:L157	R:R:P158	4.93	Yes	No	0	7	3
105	R:R:L157	R:R:Y161	14.07	Yes	Yes	4	7	7
106	R:R:F167	R:R:Y196	5.16	No	Yes	0	6	6
107	R:R:F167	R:R:L203	6.09	No	No	0	6	5
108	R:R:L170	R:R:P171	4.93	No	Yes	3	7	9
109	R:R:L170	R:R:Y175	10.55	No	No	0	7	4
110	R:R:L170	R:R:Y196	4.69	No	Yes	3	7	6
111	R:R:P171	R:R:Y178	9.74	Yes	Yes	3	9	6
112	R:R:P171	R:R:Y196	13.91	Yes	Yes	3	9	6
113	R:R:L172	R:R:Y178	3.52	No	Yes	3	4	6
114	R:R:Q177	R:R:R190	12.85	No	No	0	3	5
115	R:R:R190	R:R:V179	7.85	No	No	0	5	4
116	R:R:W186	R:R:Y181	12.54	Yes	Yes	1	7	8
117	R:R:F188	R:R:Y181	5.16	Yes	Yes	0	8	8
118	R:R:H191	R:R:Y181	7.62	No	Yes	0	6	8
119	R:R:D297	R:R:Y181	9.2	No	Yes	1	6	8
120	R:R:C182	R:R:P183	3.77	No	No	0	3	8
121	R:R:P183	R:R:W186	12.16	No	Yes	1	8	7
122	R:R:L298	R:R:P183	8.21	Yes	No	1	6	8
123	L:L:?1	R:R:T185	5.87	Yes	No	0	0	8
124	R:R:D297	R:R:W186	4.47	No	Yes	1	6	7
125	R:R:L298	R:R:W186	3.42	Yes	Yes	1	6	7
126	R:R:L301	R:R:W186	3.42	No	Yes	0	7	7
127	L:L:?1	R:R:W186	10.58	Yes	Yes	1	0	7
128	R:R:F188	R:R:I189	8.79	Yes	No	0	8	6
129	R:R:F188	R:R:F280	4.29	Yes	Yes	0	8	8
130	R:R:I189	R:R:Y196	3.63	No	Yes	0	6	6
131	R:R:I189	R:R:L197	8.56	No	No	0	6	7
132	R:R:R190	R:R:R193	9.6	No	No	0	5	5
133	R:R:H191	R:R:L197	6.43	No	No	0	6	7
134	R:R:E288	R:R:H191	20.92	No	No	0	5	6
135	R:R:Q198	R:R:Y285	3.38	No	No	0	4	5
136	R:R:L204	R:R:Y200	9.38	No	Yes	0	7	7
137	R:R:F280	R:R:Y200	4.13	Yes	Yes	0	8	7
138	R:R:A201	R:R:Y285	5.34	No	No	0	7	5
139	R:R:T202	R:R:Y285	3.75	No	No	0	4	5
140	R:R:L205	R:R:T281	4.42	No	No	0	6	7
141	R:R:F273	R:R:I208	7.54	Yes	Yes	6	8	8
142	R:R:I208	R:R:S277	6.19	Yes	No	6	8	9
143	R:R:F273	R:R:V211	10.49	Yes	No	0	8	8
144	R:R:N215	R:R:T270	5.85	No	No	0	9	8
145	R:R:I219	R:R:L263	4.28	No	No	0	7	7
146	R:R:I219	R:R:L266	4.28	No	No	0	7	8
147	R:R:L220	R:R:R224	3.64	No	Yes	0	3	5
148	R:R:I223	R:R:R227	5.01	No	No	0	5	5
149	R:R:I223	R:R:L263	5.71	No	No	0	5	7
150	R:R:M225	R:R:R228	3.72	No	No	0	7	5
151	R:R:E259	R:R:H226	16	No	No	0	8	5
152	R:R:A257	R:R:E259	4.53	No	No	0	5	8
153	R:R:D261	R:R:E258	3.9	No	No	0	8	6
154	R:R:E258	R:R:H262	4.92	No	No	0	6	8
155	R:R:E258	R:R:R324	5.82	No	No	0	6	5
156	R:R:D261	R:R:P320	9.66	No	Yes	0	8	7
157	R:R:D261	R:R:L323	12.21	No	No	0	8	7
158	R:R:H262	R:R:P320	9.15	No	Yes	0	8	7
159	R:R:F315	R:R:M269	7.46	Yes	No	0	9	9
160	R:R:I310	R:R:T272	4.56	No	No	0	7	7
161	R:R:F273	R:R:S277	3.96	Yes	No	6	8	9
162	R:R:F273	R:R:N307	4.83	Yes	No	0	8	9
163	R:R:C276	R:R:I306	4.91	No	No	0	9	4
164	R:R:F303	R:R:P279	4.33	No	No	0	6	9
165	R:R:F280	R:R:L301	4.87	Yes	No	0	8	7
166	R:R:F280	R:R:L304	6.09	Yes	No	0	8	8
167	R:R:F283	R:R:I282	5.02	Yes	No	0	4	6
168	R:R:F283	R:R:W296	14.03	Yes	No	0	4	3
169	R:R:A300	R:R:F283	5.55	No	Yes	0	7	4
170	R:R:N287	R:R:T289	8.77	No	No	0	6	3
171	R:R:E288	R:R:R292	17.45	No	No	0	5	1
172	R:R:K293	R:R:T289	7.51	No	No	0	3	3
173	R:R:D297	R:R:R292	3.57	No	No	0	6	1
174	R:R:E294	R:R:W296	14.17	No	No	0	3	3
175	R:R:L298	R:R:R302	12.15	Yes	Yes	1	6	8
176	L:L:?1	R:R:L298	4.59	Yes	Yes	1	0	6
177	R:R:Q299	R:R:R302	3.5	No	Yes	0	4	8
178	R:R:F303	R:R:Q299	3.51	No	No	0	6	4
179	L:L:?1	R:R:R302	3.23	Yes	Yes	1	0	8
180	L:L:?1	R:R:S305	12.96	Yes	No	0	0	8
181	R:R:D311	R:R:N307	9.42	No	No	0	9	9
182	L:L:?1	R:R:S308	9.97	Yes	No	0	0	8
183	L:L:?1	R:R:I309	3.79	Yes	No	0	0	9
184	R:R:D311	R:R:P312	3.22	No	Yes	0	9	9
185	R:R:I317	R:R:W313	7.05	Yes	No	0	8	6
186	R:R:L318	R:R:W313	10.25	No	No	0	6	6
187	R:R:P320	R:R:P321	5.84	Yes	No	0	7	7
188	R:R:C83	R:R:L79	3.17	No	No	0	7	8
189	R:R:C109	R:R:L102	3.17	No	No	0	9	3
190	R:R:A47	R:R:L43	3.15	No	No	0	3	8
191	R:R:A274	R:R:L212	3.15	No	No	0	6	7
192	R:R:I138	R:R:S137	3.1	No	No	0	8	9
193	R:R:I160	R:R:V156	3.07	No	No	0	6	4
194	R:R:I310	R:R:V314	3.07	No	No	0	7	8
195	R:R:L206	R:R:S210	3	No	No	0	4	5
196	R:R:N96	R:R:S92	2.98	No	No	0	5	5
197	R:R:L205	R:R:V209	2.98	No	No	0	6	4
198	R:R:I317	R:R:I41	2.94	Yes	No	0	8	5
199	R:R:I306	R:R:M31	2.92	No	No	0	4	8
200	R:R:P104	R:R:R95	2.88	No	No	0	3	4
201	R:R:P320	R:R:R319	2.88	Yes	No	0	7	9
202	R:R:I41	R:R:L37	2.85	No	No	0	5	5
203	R:R:E73	R:R:V69	2.85	No	Yes	0	7	7
204	R:R:I208	R:R:L212	2.85	Yes	No	0	8	7
205	R:R:I208	R:R:L278	2.85	Yes	No	0	8	6
206	R:R:I264	R:R:L323	2.85	No	No	0	6	7
207	R:R:E23	R:R:T98	2.82	No	No	0	1	4
208	R:R:H68	R:R:S65	2.79	No	No	0	8	8
209	R:R:L222	R:R:L263	2.77	No	No	0	8	7
210	R:R:H68	R:R:T72	2.74	No	No	0	8	5
211	R:R:H226	R:R:T260	2.74	No	No	0	5	5
212	R:R:C214	R:R:Y135	2.69	No	Yes	0	7	6
213	R:R:A115	R:R:Y111	2.67	No	No	0	5	6
214	R:R:A122	R:R:Y161	2.67	No	Yes	0	7	7
215	R:R:L99	R:R:Q97	2.66	No	No	0	4	3
216	R:R:R193	R:R:T194	2.59	No	No	0	5	3
217	R:R:F216	R:R:T270	2.59	No	No	0	5	8
218	R:R:S120	R:R:Y200	2.54	No	Yes	0	7	7
219	R:R:V218	R:R:Y135	2.52	No	Yes	0	9	6
220	R:R:F283	R:R:M286	2.49	Yes	No	0	4	4
221	R:R:V314	R:R:W313	2.45	No	No	0	8	6
222	R:R:L45	R:R:R48	2.43	No	No	0	7	5
223	R:R:L330	R:R:R327	2.43	No	No	0	5	3
224	R:R:N221	R:R:R224	2.41	No	Yes	0	6	5
225	R:R:R224	R:R:R227	2.13	Yes	No	0	5	5
226	R:R:R224	R:R:R228	2.13	Yes	No	0	5	5
227	R:R:G152	R:R:G153	2.11	No	No	0	5	7
228	R:R:G176	R:R:P171	2.03	No	Yes	0	8	9
229	R:R:A34	R:R:G35	1.95	No	No	0	6	9
230	R:R:A101	R:R:G184	1.95	No	No	0	3	5
231	R:R:A42	R:R:P312	1.87	No	Yes	0	9	9
232	R:R:G153	R:R:V69	1.84	No	Yes	0	7	7
233	R:R:A113	R:R:C187	1.81	No	No	0	7	9
234	R:R:A316	R:R:A42	1.79	No	No	7	9	9
235	R:R:A201	R:R:A284	1.79	No	No	0	7	5
236	R:R:P87	R:R:S86	1.78	No	No	0	7	8
237	R:R:G38	R:R:I41	1.76	No	No	0	9	5
238	R:R:A26	R:R:S24	1.71	No	No	0	4	6
239	R:R:C276	R:R:V275	1.71	No	No	0	9	5
240	R:R:A129	R:R:V156	1.7	No	No	0	7	4
241	R:R:G176	R:R:Q177	1.64	No	No	0	8	3
242	R:R:G184	R:R:Q180	1.64	No	No	0	5	4
243	R:R:L265	R:R:P320	1.64	No	Yes	0	8	7
244	R:R:A42	R:R:I317	1.62	No	Yes	7	9	8
245	R:R:C182	R:R:K295	1.62	No	No	0	3	1
246	R:R:S210	R:R:V209	1.62	No	No	0	5	4
247	R:R:A316	R:R:I317	1.62	No	Yes	7	9	8
248	R:R:S328	R:R:V329	1.62	No	No	0	4	4
249	R:R:V159	R:R:V163	1.6	No	No	0	3	3
250	R:R:C214	R:R:L132	1.59	No	No	0	7	6
251	R:R:A44	R:R:L45	1.58	No	No	0	4	7
252	R:R:A300	R:R:L301	1.58	No	No	0	7	7
253	R:R:I271	R:R:V275	1.54	No	No	0	6	5
254	R:R:H140	R:R:P141	1.53	No	No	0	5	9
255	R:R:C187	R:R:Q180	1.53	No	No	0	9	4
256	R:R:M286	R:R:S291	1.53	No	No	0	4	1
257	R:R:I268	R:R:T272	1.52	No	No	0	5	7
258	R:R:G192	R:R:R193	1.5	No	No	0	3	5
259	R:R:L325	R:R:S328	1.5	No	No	0	5	4
260	R:R:L43	R:R:V75	1.49	No	No	0	8	9
261	R:R:L99	R:R:V100	1.49	No	No	0	4	3
262	R:R:L125	R:R:V163	1.49	No	No	0	6	3
263	R:R:N287	R:R:S290	1.49	No	No	0	6	2
264	R:R:L199	R:R:T202	1.47	No	No	0	5	4
265	R:R:L172	R:R:L173	1.38	No	No	0	4	3
266	R:R:E259	R:R:L222	1.33	No	No	0	8	8
267	R:R:R107	R:R:S106	1.32	No	No	0	2	2
268	R:R:R150	R:R:S151	1.32	No	No	0	4	4
269	R:R:R150	R:R:V69	1.31	No	Yes	0	4	7
270	R:R:E288	R:R:N287	1.31	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F32	8.5575	4	1	8
2	R:R:V69	2.6175	4	0	7
3	R:R:L74	5.095	4	2	9
4	R:R:D78	6.2525	4	0	9
5	R:R:F118	7.5375	4	0	7
6	R:R:F119	6.252	5	1	8
7	R:R:Y135	4.978	5	5	6
8	R:R:Y144	8.2225	4	2	8
9	R:R:L157	8.26	4	4	7
10	R:R:Y161	7.072	5	4	7
11	R:R:P171	7.6525	4	3	9
12	R:R:Y178	6.55	5	3	6
13	R:R:Y181	8.63	4	1	8
14	R:R:W186	7.765	6	1	7
15	R:R:F188	5.172	5	0	8
16	R:R:Y196	6.8475	4	3	6
17	R:R:Y200	6.35	5	0	7
18	R:R:I208	4.8575	4	6	8
19	R:R:R224	2.5775	4	0	5
20	R:R:F273	6.705	4	6	8
21	R:R:F280	4.845	4	0	8
22	R:R:F283	6.7725	4	0	4
23	R:R:L298	7.0925	4	1	6
24	R:R:R302	5.67833	6	1	8
25	R:R:P312	4.316	5	0	9
26	R:R:F315	6.07	4	2	9
27	R:R:I317	3.3075	4	7	8
28	R:R:P320	5.834	5	0	7
29	L:L:?1	6.46667	18	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y93	10.0017	3.89	Yes	No	0	0	7
2	R:R:D78	R:R:P312	56.1592	6.44	Yes	Yes	0	9	9
3	R:R:D78	R:R:T123	65.1992	5.78	Yes	No	0	9	8
4	L:L:?1	R:R:T123	65.1906	3.91	Yes	No	0	0	8
5	R:R:D78	R:R:S308	65.1693	7.36	Yes	No	0	9	8
6	L:L:?1	R:R:S308	65.2505	9.97	Yes	No	0	0	8
7	R:R:P312	R:R:V75	13.4339	3.53	Yes	No	0	9	9
8	R:R:L66	R:R:L70	24.5042	5.54	No	No	2	6	7
9	R:R:L70	R:R:M130	50.4402	4.24	No	No	2	7	9
10	R:R:L74	R:R:M130	46.867	5.65	Yes	No	2	9	9
11	R:R:D78	R:R:L74	100	5.43	Yes	Yes	0	9	9
12	R:R:E133	R:R:L70	24.4999	5.3	No	No	2	9	7
13	R:R:L66	R:R:Y144	22.9997	3.52	No	Yes	2	6	8
14	R:R:E133	R:R:Y144	22.9997	7.86	No	Yes	2	9	8
15	R:R:F315	R:R:L74	46.4909	3.65	Yes	Yes	2	9	9
16	R:R:F315	R:R:F67	19.3922	3.22	Yes	No	0	9	8
17	R:R:F67	R:R:R319	18.0074	5.34	No	No	0	8	9
18	R:R:E73	R:R:V69	10.2026	2.85	No	Yes	0	7	7
19	R:R:E73	R:R:L157	11.8738	7.95	No	Yes	0	7	7
20	R:R:L157	R:R:Y161	15.1522	14.07	Yes	Yes	4	7	7
21	R:R:F118	R:R:Y161	21.7217	6.19	Yes	Yes	0	7	7
22	R:R:F118	R:R:F119	26.5302	7.5	Yes	Yes	0	7	8
23	L:L:?1	R:R:F119	35.8224	4.04	Yes	Yes	1	0	8
24	R:R:L74	R:R:M126	16.8961	5.65	Yes	No	0	9	8
25	L:L:?1	R:R:M116	52.5303	6.57	Yes	No	0	0	7
26	R:R:A113	R:R:Y178	10.318	9.34	No	Yes	0	7	6
27	R:R:P171	R:R:Y178	18.8152	9.74	Yes	Yes	3	9	6
28	R:R:P171	R:R:Y196	29.5136	13.91	Yes	Yes	3	9	6
29	R:R:I189	R:R:Y196	33.4673	3.63	No	Yes	0	6	6
30	R:R:F188	R:R:I189	35.1	8.79	Yes	No	0	8	6
31	R:R:F188	R:R:M116	50.3377	3.73	Yes	No	0	8	7
32	R:R:F188	R:R:F280	10.4505	4.29	Yes	Yes	0	8	8
33	R:R:F280	R:R:Y200	14.105	4.13	Yes	Yes	0	8	7
34	L:L:?1	R:R:W186	39.9	10.58	Yes	Yes	1	0	7
35	R:R:L301	R:R:W186	19.4136	3.42	No	Yes	0	7	7
36	R:R:F280	R:R:L301	10.7882	4.87	Yes	No	0	8	7
37	R:R:L204	R:R:Y200	13.0749	9.38	No	Yes	0	7	7
38	R:R:L204	R:R:M124	11.5533	5.65	No	No	0	7	7
39	R:R:L207	R:R:M124	10.9805	5.65	No	No	0	7	7
40	R:R:L125	R:R:L207	10.2026	5.54	No	No	0	6	7
41	R:R:I160	R:R:L125	12.4081	12.85	No	No	0	6	6
42	R:R:I160	R:R:M126	15.4727	5.83	No	No	0	6	8
43	R:R:D311	R:R:P312	18.3322	3.22	No	Yes	0	9	9
44	R:R:F128	R:R:L207	12.2799	4.87	No	No	0	6	7
45	R:R:F128	R:R:S210	10.2539	3.96	No	No	0	6	5
46	R:R:F273	R:R:N307	13.4339	4.83	Yes	No	0	8	9
47	R:R:D311	R:R:N307	15.0752	9.42	No	No	0	9	9
48	R:R:M269	R:R:R134	31.2789	4.96	No	No	0	9	9
49	R:R:F315	R:R:M269	32.5483	7.46	Yes	No	0	9	9
50	R:R:L266	R:R:R134	25.5941	3.64	No	No	0	8	9
51	R:R:L136	R:R:Y135	12.6988	3.52	No	Yes	5	5	6
52	R:R:V218	R:R:Y135	31.5823	2.52	No	Yes	0	9	6
53	R:R:I138	R:R:V218	34.1725	4.61	No	No	0	8	9
54	R:R:I138	R:R:S137	37.2756	3.1	No	No	0	8	9
55	R:R:S137	R:R:Y144	40.3701	7.63	No	Yes	0	9	8
56	R:R:I223	R:R:R227	11.4379	5.01	No	No	0	5	5
57	R:R:I223	R:R:L263	13.0663	5.71	No	No	0	5	7
58	R:R:I219	R:R:L263	22.709	4.28	No	No	0	7	7
59	R:R:I219	R:R:L266	24.0297	4.28	No	No	0	7	8
60	R:R:G176	R:R:P171	10.318	2.03	No	Yes	0	8	9
61	R:R:W186	R:R:Y181	10.5574	12.54	Yes	Yes	1	7	8
62	R:R:P320	R:R:R319	16.661	2.88	Yes	No	0	7	9
63	R:R:I317	R:R:W313	10.1257	7.05	Yes	No	0	8	6
64	R:R:A42	R:R:I317	16.6652	1.62	No	Yes	7	9	8
65	R:R:A42	R:R:P312	19.9479	1.87	No	Yes	0	9	9
66	R:R:A300	R:R:L301	10.9463	1.58	No	No	0	7	7
67	R:R:E288	R:R:N287	11.3823	1.31	No	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P25	R:R:Y93	9.74	0	No	No	5	7	2	1
R:R:I27	R:R:R302	7.52	0	No	Yes	4	8	2	1
R:R:R302	R:R:S28	3.95	1	Yes	No	8	7	1	1
L:L:?1	R:R:S28	7.97	1	Yes	No	0	7	0	1
R:R:M31	R:R:R302	3.72	1	No	Yes	8	8	1	1
L:L:?1	R:R:M31	4.69	1	Yes	No	0	8	0	1
R:R:F32	R:R:V36	3.93	1	Yes	No	8	7	1	2
R:R:F32	R:R:T82	9.08	1	Yes	No	8	8	1	1
R:R:F32	R:R:S86	17.18	1	Yes	No	8	8	1	1
L:L:?1	R:R:F32	4.04	1	Yes	Yes	0	8	0	1
R:R:G35	R:R:I309	7.05	0	No	No	9	9	2	1
R:R:T82	R:R:V36	4.76	1	No	No	8	7	1	2
R:R:D78	R:R:T123	5.78	0	Yes	No	9	8	2	1
R:R:D78	R:R:S308	7.36	0	Yes	No	9	8	2	1
R:R:F119	R:R:G81	10.54	1	Yes	No	8	9	1	2
L:L:?1	R:R:T82	7.83	1	Yes	No	0	8	0	1
R:R:A115	R:R:I85	3.25	1	No	No	5	6	2	1
R:R:F119	R:R:I85	5.02	1	Yes	No	8	6	1	1
L:L:?1	R:R:I85	7.58	1	Yes	No	0	6	0	1
L:L:?1	R:R:S86	6.98	1	Yes	No	0	8	0	1
R:R:F112	R:R:V89	3.93	0	No	No	5	7	2	1
L:L:?1	R:R:V89	7.91	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y93	3.89	1	Yes	No	0	7	0	1
R:R:F112	R:R:M116	3.73	0	No	No	5	7	2	1
R:R:A115	R:R:F119	4.16	1	No	Yes	5	8	2	1
R:R:F188	R:R:M116	3.73	0	Yes	No	8	7	2	1
L:L:?1	R:R:M116	6.57	1	Yes	No	0	7	0	1
R:R:F118	R:R:F119	7.5	0	Yes	Yes	7	8	2	1
L:L:?1	R:R:F119	4.04	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T123	3.91	1	Yes	No	0	8	0	1
R:R:W186	R:R:Y181	12.54	1	Yes	Yes	7	8	1	2
R:R:F188	R:R:Y181	5.16	0	Yes	Yes	8	8	2	2
R:R:D297	R:R:Y181	9.2	1	No	Yes	6	8	2	2
R:R:P183	R:R:W186	12.16	1	No	Yes	8	7	2	1
R:R:L298	R:R:P183	8.21	1	Yes	No	6	8	1	2
L:L:?1	R:R:T185	5.87	1	Yes	No	0	8	0	1
R:R:D297	R:R:W186	4.47	1	No	Yes	6	7	2	1
R:R:L298	R:R:W186	3.42	1	Yes	Yes	6	7	1	1
R:R:L301	R:R:W186	3.42	0	No	Yes	7	7	2	1
L:L:?1	R:R:W186	10.58	1	Yes	Yes	0	7	0	1
R:R:L298	R:R:R302	12.15	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:L298	4.59	1	Yes	Yes	0	6	0	1
R:R:Q299	R:R:R302	3.5	0	No	Yes	4	8	2	1
L:L:?1	R:R:R302	3.23	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S305	12.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:S308	9.97	1	Yes	No	0	8	0	1
L:L:?1	R:R:I309	3.79	1	Yes	No	0	9	0	1
R:R:I306	R:R:M31	2.92	0	No	No	4	8	2	1
R:R:P87	R:R:S86	1.78	0	No	No	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7CX3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	248
Number of Links	270
Number of Hubs	29
Number of Links mediated by Hubs	122
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	48267
Length Of Smallest Path	3
Average Path Length	12.401
Length of Longest Path	27
Minimum Path Strength	1.315
Average Path Strength	5.7466
Maximum Path Strength	19.185
Minimum Path Correlation	0.7
Average Path Correlation	0.913316
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	46.5481
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.4148
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GNO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	GNO
Name	Taprenepag
Synonyms	Taprenepag
Identifier
Formula	C24 H22 N4 O5 S
Molecular Weight	478.52
SMILES
PubChem	18376177
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	59
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43116
Sequence	>7CX3_nogp_Chain_R E S P A I S S V M F S A G V L G N L I A L A L L A R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N Q T L V A L A P E S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H P Y F Y Q R R V S R S G G L A V L P V I Y A V S L L F C S L P L L D Y G Q Y V Q Y C P G T W C F I R H G R T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M N E T S S R K E K W D L Q A L R F L S I N S I I D P W V F A I L R P P V L R L M R S V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7CX2	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX2 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-	Gs/β1/γ2	2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX3 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-		2.8	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-	Gs/β1/γ2	2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268
	7CX4 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-		2.9	2021-05-05	doi.org/10.1126/sciadv.abf1268

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7CX3_nogp.zip

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