psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P25	R:R:S24	3.56	No	No	0	5	6
2	R:R:P25	R:R:S29	5.34	No	No	0	5	4
3	R:R:P25	R:R:Y93	9.74	No	No	0	5	7
4	R:R:I27	R:R:R302	7.52	No	Yes	0	4	8
5	R:R:R302	R:R:S28	3.95	Yes	No	1	8	7
6	L:L:?1	R:R:S28	7.97	Yes	No	1	0	7
7	R:R:L90	R:R:S29	4.5	No	No	0	7	4
8	R:R:M31	R:R:R302	3.72	No	Yes	1	8	8
9	L:L:?1	R:R:M31	4.69	Yes	No	1	0	8
10	R:R:F32	R:R:V36	3.93	Yes	No	1	8	7
11	R:R:F32	R:R:T82	9.08	Yes	No	1	8	8
12	R:R:F32	R:R:S86	17.18	Yes	No	1	8	8
13	L:L:?1	R:R:F32	4.04	Yes	Yes	1	0	8
14	R:R:G35	R:R:I309	7.05	No	No	0	9	9
15	R:R:T82	R:R:V36	4.76	No	No	1	8	7
16	R:R:L79	R:R:N39	4.12	No	No	0	8	9
17	R:R:N39	R:R:P312	6.52	No	Yes	0	9	9
18	R:R:L40	R:R:L79	4.15	No	No	0	5	8
19	R:R:L46	R:R:V71	4.47	No	No	0	9	8
20	R:R:L46	R:R:T72	5.9	No	No	0	9	5
21	R:R:L46	R:R:V75	4.47	No	No	0	9	9
22	R:R:L66	R:R:L70	5.54	No	No	2	6	7
23	R:R:E133	R:R:L66	6.63	No	No	2	9	6
24	R:R:L66	R:R:Y144	3.52	No	Yes	2	6	8
25	R:R:F315	R:R:F67	3.22	Yes	No	0	9	8
26	R:R:F67	R:R:R319	5.34	No	No	0	8	9
27	R:R:L154	R:R:V69	4.47	No	Yes	0	5	7
28	R:R:L70	R:R:M130	4.24	No	No	2	7	9
29	R:R:E133	R:R:L70	5.3	No	No	2	9	7
30	R:R:E73	R:R:L157	7.95	No	Yes	0	7	7
31	R:R:D78	R:R:L74	5.43	Yes	Yes	0	9	9
32	R:R:L74	R:R:M126	5.65	Yes	No	0	9	8
33	R:R:L74	R:R:M130	5.65	Yes	No	2	9	9
34	R:R:F315	R:R:L74	3.65	Yes	Yes	2	9	9
35	R:R:P312	R:R:V75	3.53	Yes	No	0	9	9
36	R:R:F76	R:R:L157	6.09	No	Yes	4	6	7
37	R:R:F76	R:R:Y161	6.19	No	Yes	4	6	7
38	R:R:T77	R:R:Y161	6.24	No	Yes	0	9	7
39	R:R:D78	R:R:T123	5.78	Yes	No	0	9	8
40	R:R:D78	R:R:S308	7.36	Yes	No	0	9	8
41	R:R:D78	R:R:P312	6.44	Yes	Yes	0	9	9
42	R:R:G81	R:R:L80	3.42	No	No	0	9	5
43	R:R:L80	R:R:L84	5.54	No	No	0	5	5
44	R:R:F119	R:R:G81	10.54	Yes	No	0	8	9
45	L:L:?1	R:R:T82	7.83	Yes	No	1	0	8
46	R:R:A115	R:R:I85	3.25	No	No	1	5	6
47	R:R:F119	R:R:I85	5.02	Yes	No	1	8	6
48	L:L:?1	R:R:I85	7.58	Yes	No	1	0	6
49	L:L:?1	R:R:S86	6.98	Yes	No	1	0	8
50	R:R:F112	R:R:V88	5.24	No	No	0	5	5
51	R:R:F112	R:R:V89	3.93	No	No	0	5	7
52	L:L:?1	R:R:V89	7.91	Yes	No	0	0	7
53	L:L:?1	R:R:Y93	3.89	Yes	No	0	0	7
54	R:R:N96	R:R:V100	4.43	No	No	0	5	3
55	R:R:A103	R:R:N96	4.69	No	No	0	5	5
56	R:R:A103	R:R:P104	3.74	No	No	0	5	3
57	R:R:A108	R:R:P104	3.74	No	No	0	5	3
58	R:R:C109	R:R:C187	7.28	No	No	0	9	9
59	R:R:T110	R:R:Y178	4.99	No	Yes	0	4	6
60	R:R:F112	R:R:M116	3.73	No	No	0	5	7
61	R:R:A113	R:R:Y178	9.34	No	Yes	0	7	6
62	R:R:F114	R:R:S169	5.28	No	No	0	7	5
63	R:R:F114	R:R:L172	4.87	No	No	3	7	4
64	R:R:F114	R:R:Y178	5.16	No	Yes	3	7	6
65	R:R:A115	R:R:F119	4.16	No	Yes	1	5	8
66	R:R:F188	R:R:M116	3.73	Yes	No	0	8	7
67	L:L:?1	R:R:M116	6.57	Yes	No	0	0	7
68	R:R:C168	R:R:T117	6.76	No	No	0	8	7
69	R:R:F188	R:R:T117	3.89	Yes	No	0	8	7
70	R:R:T117	R:R:Y200	7.49	No	Yes	0	7	7
71	R:R:F118	R:R:F119	7.5	Yes	Yes	0	7	8
72	R:R:F118	R:R:Y161	6.19	Yes	Yes	0	7	7
73	R:R:F118	R:R:S164	7.93	Yes	No	0	7	7
74	R:R:F118	R:R:L165	8.53	Yes	No	0	7	4
75	L:L:?1	R:R:F119	4.04	Yes	Yes	1	0	8
76	R:R:F167	R:R:L121	3.65	No	No	0	6	7
77	R:R:L121	R:R:Y200	8.21	No	Yes	0	7	7
78	L:L:?1	R:R:T123	3.91	Yes	No	0	0	8
79	R:R:L204	R:R:M124	5.65	No	No	0	7	7
80	R:R:L207	R:R:M124	5.65	No	No	0	7	7
81	R:R:I160	R:R:L125	12.85	No	No	0	6	6
82	R:R:L125	R:R:L207	5.54	No	No	0	6	7
83	R:R:I160	R:R:M126	5.83	No	No	0	6	8
84	R:R:D311	R:R:L127	10.86	No	No	0	9	8
85	R:R:F128	R:R:L207	4.87	No	No	0	6	7
86	R:R:F128	R:R:S210	3.96	No	No	0	6	5
87	R:R:F315	R:R:M130	9.95	Yes	No	2	9	9
88	R:R:A131	R:R:V211	3.39	No	No	0	9	8
89	R:R:E133	R:R:Y144	7.86	No	Yes	2	9	8
90	R:R:N215	R:R:R134	6.03	No	No	0	9	9
91	R:R:L266	R:R:R134	3.64	No	No	0	8	9
92	R:R:M269	R:R:R134	4.96	No	No	0	9	9
93	R:R:L136	R:R:Y135	3.52	No	Yes	5	5	6
94	R:R:H140	R:R:Y135	9.8	No	Yes	5	5	6
95	R:R:S217	R:R:Y135	6.36	No	Yes	0	6	6
96	R:R:H140	R:R:L136	3.86	No	No	5	5	5
97	R:R:F143	R:R:L136	3.65	No	No	0	4	5
98	R:R:S137	R:R:Y144	7.63	No	Yes	0	9	8
99	R:R:I138	R:R:V218	4.61	No	No	0	8	9
100	R:R:G139	R:R:N221	5.09	No	No	0	7	6
101	R:R:F143	R:R:R147	5.34	No	No	0	4	4
102	R:R:V148	R:R:Y144	13.88	No	Yes	0	5	8
103	R:R:R146	R:R:R147	12.79	No	No	0	5	4
104	R:R:L157	R:R:P158	4.93	Yes	No	0	7	3
105	R:R:L157	R:R:Y161	14.07	Yes	Yes	4	7	7
106	R:R:F167	R:R:Y196	5.16	No	Yes	0	6	6
107	R:R:F167	R:R:L203	6.09	No	No	0	6	5
108	R:R:L170	R:R:P171	4.93	No	Yes	3	7	9
109	R:R:L170	R:R:Y175	10.55	No	No	0	7	4
110	R:R:L170	R:R:Y196	4.69	No	Yes	3	7	6
111	R:R:P171	R:R:Y178	9.74	Yes	Yes	3	9	6
112	R:R:P171	R:R:Y196	13.91	Yes	Yes	3	9	6
113	R:R:L172	R:R:Y178	3.52	No	Yes	3	4	6
114	R:R:Q177	R:R:R190	12.85	No	No	0	3	5
115	R:R:R190	R:R:V179	7.85	No	No	0	5	4
116	R:R:W186	R:R:Y181	12.54	Yes	Yes	1	7	8
117	R:R:F188	R:R:Y181	5.16	Yes	Yes	0	8	8
118	R:R:H191	R:R:Y181	7.62	No	Yes	0	6	8
119	R:R:D297	R:R:Y181	9.2	No	Yes	1	6	8
120	R:R:C182	R:R:P183	3.77	No	No	0	3	8
121	R:R:P183	R:R:W186	12.16	No	Yes	1	8	7
122	R:R:L298	R:R:P183	8.21	Yes	No	1	6	8
123	L:L:?1	R:R:T185	5.87	Yes	No	0	0	8
124	R:R:D297	R:R:W186	4.47	No	Yes	1	6	7
125	R:R:L298	R:R:W186	3.42	Yes	Yes	1	6	7
126	R:R:L301	R:R:W186	3.42	No	Yes	0	7	7
127	L:L:?1	R:R:W186	10.58	Yes	Yes	1	0	7
128	R:R:F188	R:R:I189	8.79	Yes	No	0	8	6
129	R:R:F188	R:R:F280	4.29	Yes	Yes	0	8	8
130	R:R:I189	R:R:Y196	3.63	No	Yes	0	6	6
131	R:R:I189	R:R:L197	8.56	No	No	0	6	7
132	R:R:R190	R:R:R193	9.6	No	No	0	5	5
133	R:R:H191	R:R:L197	6.43	No	No	0	6	7
134	R:R:E288	R:R:H191	20.92	No	No	0	5	6
135	R:R:Q198	R:R:Y285	3.38	No	No	0	4	5
136	R:R:L204	R:R:Y200	9.38	No	Yes	0	7	7
137	R:R:F280	R:R:Y200	4.13	Yes	Yes	0	8	7
138	R:R:A201	R:R:Y285	5.34	No	No	0	7	5
139	R:R:T202	R:R:Y285	3.75	No	No	0	4	5
140	R:R:L205	R:R:T281	4.42	No	No	0	6	7
141	R:R:F273	R:R:I208	7.54	Yes	Yes	6	8	8
142	R:R:I208	R:R:S277	6.19	Yes	No	6	8	9
143	R:R:F273	R:R:V211	10.49	Yes	No	0	8	8
144	R:R:N215	R:R:T270	5.85	No	No	0	9	8
145	R:R:I219	R:R:L263	4.28	No	No	0	7	7
146	R:R:I219	R:R:L266	4.28	No	No	0	7	8
147	R:R:L220	R:R:R224	3.64	No	Yes	0	3	5
148	R:R:I223	R:R:R227	5.01	No	No	0	5	5
149	R:R:I223	R:R:L263	5.71	No	No	0	5	7
150	R:R:M225	R:R:R228	3.72	No	No	0	7	5
151	R:R:E259	R:R:H226	16	No	No	0	8	5
152	R:R:A257	R:R:E259	4.53	No	No	0	5	8
153	R:R:D261	R:R:E258	3.9	No	No	0	8	6
154	R:R:E258	R:R:H262	4.92	No	No	0	6	8
155	R:R:E258	R:R:R324	5.82	No	No	0	6	5
156	R:R:D261	R:R:P320	9.66	No	Yes	0	8	7
157	R:R:D261	R:R:L323	12.21	No	No	0	8	7
158	R:R:H262	R:R:P320	9.15	No	Yes	0	8	7
159	R:R:F315	R:R:M269	7.46	Yes	No	0	9	9
160	R:R:I310	R:R:T272	4.56	No	No	0	7	7
161	R:R:F273	R:R:S277	3.96	Yes	No	6	8	9
162	R:R:F273	R:R:N307	4.83	Yes	No	0	8	9
163	R:R:C276	R:R:I306	4.91	No	No	0	9	4
164	R:R:F303	R:R:P279	4.33	No	No	0	6	9
165	R:R:F280	R:R:L301	4.87	Yes	No	0	8	7
166	R:R:F280	R:R:L304	6.09	Yes	No	0	8	8
167	R:R:F283	R:R:I282	5.02	Yes	No	0	4	6
168	R:R:F283	R:R:W296	14.03	Yes	No	0	4	3
169	R:R:A300	R:R:F283	5.55	No	Yes	0	7	4
170	R:R:N287	R:R:T289	8.77	No	No	0	6	3
171	R:R:E288	R:R:R292	17.45	No	No	0	5	1
172	R:R:K293	R:R:T289	7.51	No	No	0	3	3
173	R:R:D297	R:R:R292	3.57	No	No	0	6	1
174	R:R:E294	R:R:W296	14.17	No	No	0	3	3
175	R:R:L298	R:R:R302	12.15	Yes	Yes	1	6	8
176	L:L:?1	R:R:L298	4.59	Yes	Yes	1	0	6
177	R:R:Q299	R:R:R302	3.5	No	Yes	0	4	8
178	R:R:F303	R:R:Q299	3.51	No	No	0	6	4
179	L:L:?1	R:R:R302	3.23	Yes	Yes	1	0	8
180	L:L:?1	R:R:S305	12.96	Yes	No	0	0	8
181	R:R:D311	R:R:N307	9.42	No	No	0	9	9
182	L:L:?1	R:R:S308	9.97	Yes	No	0	0	8
183	L:L:?1	R:R:I309	3.79	Yes	No	0	0	9
184	R:R:D311	R:R:P312	3.22	No	Yes	0	9	9
185	R:R:I317	R:R:W313	7.05	Yes	No	0	8	6
186	R:R:L318	R:R:W313	10.25	No	No	0	6	6
187	R:R:P320	R:R:P321	5.84	Yes	No	0	7	7
188	R:R:C83	R:R:L79	3.17	No	No	0	7	8
189	R:R:C109	R:R:L102	3.17	No	No	0	9	3
190	R:R:A47	R:R:L43	3.15	No	No	0	3	8
191	R:R:A274	R:R:L212	3.15	No	No	0	6	7
192	R:R:I138	R:R:S137	3.1	No	No	0	8	9
193	R:R:I160	R:R:V156	3.07	No	No	0	6	4
194	R:R:I310	R:R:V314	3.07	No	No	0	7	8
195	R:R:L206	R:R:S210	3	No	No	0	4	5
196	R:R:N96	R:R:S92	2.98	No	No	0	5	5
197	R:R:L205	R:R:V209	2.98	No	No	0	6	4
198	R:R:I317	R:R:I41	2.94	Yes	No	0	8	5
199	R:R:I306	R:R:M31	2.92	No	No	0	4	8
200	R:R:P104	R:R:R95	2.88	No	No	0	3	4
201	R:R:P320	R:R:R319	2.88	Yes	No	0	7	9
202	R:R:I41	R:R:L37	2.85	No	No	0	5	5
203	R:R:E73	R:R:V69	2.85	No	Yes	0	7	7
204	R:R:I208	R:R:L212	2.85	Yes	No	0	8	7
205	R:R:I208	R:R:L278	2.85	Yes	No	0	8	6
206	R:R:I264	R:R:L323	2.85	No	No	0	6	7
207	R:R:E23	R:R:T98	2.82	No	No	0	1	4
208	R:R:H68	R:R:S65	2.79	No	No	0	8	8
209	R:R:L222	R:R:L263	2.77	No	No	0	8	7
210	R:R:H68	R:R:T72	2.74	No	No	0	8	5
211	R:R:H226	R:R:T260	2.74	No	No	0	5	5
212	R:R:C214	R:R:Y135	2.69	No	Yes	0	7	6
213	R:R:A115	R:R:Y111	2.67	No	No	0	5	6
214	R:R:A122	R:R:Y161	2.67	No	Yes	0	7	7
215	R:R:L99	R:R:Q97	2.66	No	No	0	4	3
216	R:R:R193	R:R:T194	2.59	No	No	0	5	3
217	R:R:F216	R:R:T270	2.59	No	No	0	5	8
218	R:R:S120	R:R:Y200	2.54	No	Yes	0	7	7
219	R:R:V218	R:R:Y135	2.52	No	Yes	0	9	6
220	R:R:F283	R:R:M286	2.49	Yes	No	0	4	4
221	R:R:V314	R:R:W313	2.45	No	No	0	8	6
222	R:R:L45	R:R:R48	2.43	No	No	0	7	5
223	R:R:L330	R:R:R327	2.43	No	No	0	5	3
224	R:R:N221	R:R:R224	2.41	No	Yes	0	6	5
225	R:R:R224	R:R:R227	2.13	Yes	No	0	5	5
226	R:R:R224	R:R:R228	2.13	Yes	No	0	5	5
227	R:R:G152	R:R:G153	2.11	No	No	0	5	7
228	R:R:G176	R:R:P171	2.03	No	Yes	0	8	9
229	R:R:A34	R:R:G35	1.95	No	No	0	6	9
230	R:R:A101	R:R:G184	1.95	No	No	0	3	5
231	R:R:A42	R:R:P312	1.87	No	Yes	0	9	9
232	R:R:G153	R:R:V69	1.84	No	Yes	0	7	7
233	R:R:A113	R:R:C187	1.81	No	No	0	7	9
234	R:R:A316	R:R:A42	1.79	No	No	7	9	9
235	R:R:A201	R:R:A284	1.79	No	No	0	7	5
236	R:R:P87	R:R:S86	1.78	No	No	0	7	8
237	R:R:G38	R:R:I41	1.76	No	No	0	9	5
238	R:R:A26	R:R:S24	1.71	No	No	0	4	6
239	R:R:C276	R:R:V275	1.71	No	No	0	9	5
240	R:R:A129	R:R:V156	1.7	No	No	0	7	4
241	R:R:G176	R:R:Q177	1.64	No	No	0	8	3
242	R:R:G184	R:R:Q180	1.64	No	No	0	5	4
243	R:R:L265	R:R:P320	1.64	No	Yes	0	8	7
244	R:R:A42	R:R:I317	1.62	No	Yes	7	9	8
245	R:R:C182	R:R:K295	1.62	No	No	0	3	1
246	R:R:S210	R:R:V209	1.62	No	No	0	5	4
247	R:R:A316	R:R:I317	1.62	No	Yes	7	9	8
248	R:R:S328	R:R:V329	1.62	No	No	0	4	4
249	R:R:V159	R:R:V163	1.6	No	No	0	3	3
250	R:R:C214	R:R:L132	1.59	No	No	0	7	6
251	R:R:A44	R:R:L45	1.58	No	No	0	4	7
252	R:R:A300	R:R:L301	1.58	No	No	0	7	7
253	R:R:I271	R:R:V275	1.54	No	No	0	6	5
254	R:R:H140	R:R:P141	1.53	No	No	0	5	9
255	R:R:C187	R:R:Q180	1.53	No	No	0	9	4
256	R:R:M286	R:R:S291	1.53	No	No	0	4	1
257	R:R:I268	R:R:T272	1.52	No	No	0	5	7
258	R:R:G192	R:R:R193	1.5	No	No	0	3	5
259	R:R:L325	R:R:S328	1.5	No	No	0	5	4
260	R:R:L43	R:R:V75	1.49	No	No	0	8	9
261	R:R:L99	R:R:V100	1.49	No	No	0	4	3
262	R:R:L125	R:R:V163	1.49	No	No	0	6	3
263	R:R:N287	R:R:S290	1.49	No	No	0	6	2
264	R:R:L199	R:R:T202	1.47	No	No	0	5	4
265	R:R:L172	R:R:L173	1.38	No	No	0	4	3
266	R:R:E259	R:R:L222	1.33	No	No	0	8	8
267	R:R:R107	R:R:S106	1.32	No	No	0	2	2
268	R:R:R150	R:R:S151	1.32	No	No	0	4	4
269	R:R:R150	R:R:V69	1.31	No	Yes	0	4	7
270	R:R:E288	R:R:N287	1.31	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F32	8.5575	4	1	8
2	R:R:V69	2.6175	4	0	7
3	R:R:L74	5.095	4	2	9
4	R:R:D78	6.2525	4	0	9
5	R:R:F118	7.5375	4	0	7
6	R:R:F119	6.252	5	1	8
7	R:R:Y135	4.978	5	5	6
8	R:R:Y144	8.2225	4	2	8
9	R:R:L157	8.26	4	4	7
10	R:R:Y161	7.072	5	4	7
11	R:R:P171	7.6525	4	3	9
12	R:R:Y178	6.55	5	3	6
13	R:R:Y181	8.63	4	1	8
14	R:R:W186	7.765	6	1	7
15	R:R:F188	5.172	5	0	8
16	R:R:Y196	6.8475	4	3	6
17	R:R:Y200	6.35	5	0	7
18	R:R:I208	4.8575	4	6	8
19	R:R:R224	2.5775	4	0	5
20	R:R:F273	6.705	4	6	8
21	R:R:F280	4.845	4	0	8
22	R:R:F283	6.7725	4	0	4
23	R:R:L298	7.0925	4	1	6
24	R:R:R302	5.67833	6	1	8
25	R:R:P312	4.316	5	0	9
26	R:R:F315	6.07	4	2	9
27	R:R:I317	3.3075	4	7	8
28	R:R:P320	5.834	5	0	7
29	L:L:?1	6.46667	18	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y93	10.0017	3.89	Yes	No	0	0	7
2	R:R:D78	R:R:P312	56.1592	6.44	Yes	Yes	0	9	9
3	R:R:D78	R:R:T123	65.1992	5.78	Yes	No	0	9	8
4	L:L:?1	R:R:T123	65.1906	3.91	Yes	No	0	0	8
5	R:R:D78	R:R:S308	65.1693	7.36	Yes	No	0	9	8
6	L:L:?1	R:R:S308	65.2505	9.97	Yes	No	0	0	8
7	R:R:P312	R:R:V75	13.4339	3.53	Yes	No	0	9	9
8	R:R:L66	R:R:L70	24.5042	5.54	No	No	2	6	7
9	R:R:L70	R:R:M130	50.4402	4.24	No	No	2	7	9
10	R:R:L74	R:R:M130	46.867	5.65	Yes	No	2	9	9
11	R:R:D78	R:R:L74	100	5.43	Yes	Yes	0	9	9
12	R:R:E133	R:R:L70	24.4999	5.3	No	No	2	9	7
13	R:R:L66	R:R:Y144	22.9997	3.52	No	Yes	2	6	8
14	R:R:E133	R:R:Y144	22.9997	7.86	No	Yes	2	9	8
15	R:R:F315	R:R:L74	46.4909	3.65	Yes	Yes	2	9	9
16	R:R:F315	R:R:F67	19.3922	3.22	Yes	No	0	9	8
17	R:R:F67	R:R:R319	18.0074	5.34	No	No	0	8	9
18	R:R:E73	R:R:V69	10.2026	2.85	No	Yes	0	7	7
19	R:R:E73	R:R:L157	11.8738	7.95	No	Yes	0	7	7
20	R:R:L157	R:R:Y161	15.1522	14.07	Yes	Yes	4	7	7
21	R:R:F118	R:R:Y161	21.7217	6.19	Yes	Yes	0	7	7
22	R:R:F118	R:R:F119	26.5302	7.5	Yes	Yes	0	7	8
23	L:L:?1	R:R:F119	35.8224	4.04	Yes	Yes	1	0	8
24	R:R:L74	R:R:M126	16.8961	5.65	Yes	No	0	9	8
25	L:L:?1	R:R:M116	52.5303	6.57	Yes	No	0	0	7
26	R:R:A113	R:R:Y178	10.318	9.34	No	Yes	0	7	6
27	R:R:P171	R:R:Y178	18.8152	9.74	Yes	Yes	3	9	6
28	R:R:P171	R:R:Y196	29.5136	13.91	Yes	Yes	3	9	6
29	R:R:I189	R:R:Y196	33.4673	3.63	No	Yes	0	6	6
30	R:R:F188	R:R:I189	35.1	8.79	Yes	No	0	8	6
31	R:R:F188	R:R:M116	50.3377	3.73	Yes	No	0	8	7
32	R:R:F188	R:R:F280	10.4505	4.29	Yes	Yes	0	8	8
33	R:R:F280	R:R:Y200	14.105	4.13	Yes	Yes	0	8	7
34	L:L:?1	R:R:W186	39.9	10.58	Yes	Yes	1	0	7
35	R:R:L301	R:R:W186	19.4136	3.42	No	Yes	0	7	7
36	R:R:F280	R:R:L301	10.7882	4.87	Yes	No	0	8	7
37	R:R:L204	R:R:Y200	13.0749	9.38	No	Yes	0	7	7
38	R:R:L204	R:R:M124	11.5533	5.65	No	No	0	7	7
39	R:R:L207	R:R:M124	10.9805	5.65	No	No	0	7	7
40	R:R:L125	R:R:L207	10.2026	5.54	No	No	0	6	7
41	R:R:I160	R:R:L125	12.4081	12.85	No	No	0	6	6
42	R:R:I160	R:R:M126	15.4727	5.83	No	No	0	6	8
43	R:R:D311	R:R:P312	18.3322	3.22	No	Yes	0	9	9
44	R:R:F128	R:R:L207	12.2799	4.87	No	No	0	6	7
45	R:R:F128	R:R:S210	10.2539	3.96	No	No	0	6	5
46	R:R:F273	R:R:N307	13.4339	4.83	Yes	No	0	8	9
47	R:R:D311	R:R:N307	15.0752	9.42	No	No	0	9	9
48	R:R:M269	R:R:R134	31.2789	4.96	No	No	0	9	9
49	R:R:F315	R:R:M269	32.5483	7.46	Yes	No	0	9	9
50	R:R:L266	R:R:R134	25.5941	3.64	No	No	0	8	9
51	R:R:L136	R:R:Y135	12.6988	3.52	No	Yes	5	5	6
52	R:R:V218	R:R:Y135	31.5823	2.52	No	Yes	0	9	6
53	R:R:I138	R:R:V218	34.1725	4.61	No	No	0	8	9
54	R:R:I138	R:R:S137	37.2756	3.1	No	No	0	8	9
55	R:R:S137	R:R:Y144	40.3701	7.63	No	Yes	0	9	8
56	R:R:I223	R:R:R227	11.4379	5.01	No	No	0	5	5
57	R:R:I223	R:R:L263	13.0663	5.71	No	No	0	5	7
58	R:R:I219	R:R:L263	22.709	4.28	No	No	0	7	7
59	R:R:I219	R:R:L266	24.0297	4.28	No	No	0	7	8
60	R:R:G176	R:R:P171	10.318	2.03	No	Yes	0	8	9
61	R:R:W186	R:R:Y181	10.5574	12.54	Yes	Yes	1	7	8
62	R:R:P320	R:R:R319	16.661	2.88	Yes	No	0	7	9
63	R:R:I317	R:R:W313	10.1257	7.05	Yes	No	0	8	6
64	R:R:A42	R:R:I317	16.6652	1.62	No	Yes	7	9	8
65	R:R:A42	R:R:P312	19.9479	1.87	No	Yes	0	9	9
66	R:R:A300	R:R:L301	10.9463	1.58	No	No	0	7	7
67	R:R:E288	R:R:N287	11.3823	1.31	No	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P25	R:R:Y93	9.74	0	No	No	5	7	2	1
R:R:I27	R:R:R302	7.52	0	No	Yes	4	8	2	1
R:R:R302	R:R:S28	3.95	1	Yes	No	8	7	1	1
L:L:?1	R:R:S28	7.97	1	Yes	No	0	7	0	1
R:R:M31	R:R:R302	3.72	1	No	Yes	8	8	1	1
L:L:?1	R:R:M31	4.69	1	Yes	No	0	8	0	1
R:R:F32	R:R:V36	3.93	1	Yes	No	8	7	1	2
R:R:F32	R:R:T82	9.08	1	Yes	No	8	8	1	1
R:R:F32	R:R:S86	17.18	1	Yes	No	8	8	1	1
L:L:?1	R:R:F32	4.04	1	Yes	Yes	0	8	0	1
R:R:G35	R:R:I309	7.05	0	No	No	9	9	2	1
R:R:T82	R:R:V36	4.76	1	No	No	8	7	1	2
R:R:D78	R:R:T123	5.78	0	Yes	No	9	8	2	1
R:R:D78	R:R:S308	7.36	0	Yes	No	9	8	2	1
R:R:F119	R:R:G81	10.54	1	Yes	No	8	9	1	2
L:L:?1	R:R:T82	7.83	1	Yes	No	0	8	0	1
R:R:A115	R:R:I85	3.25	1	No	No	5	6	2	1
R:R:F119	R:R:I85	5.02	1	Yes	No	8	6	1	1
L:L:?1	R:R:I85	7.58	1	Yes	No	0	6	0	1
L:L:?1	R:R:S86	6.98	1	Yes	No	0	8	0	1
R:R:F112	R:R:V89	3.93	0	No	No	5	7	2	1
L:L:?1	R:R:V89	7.91	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y93	3.89	1	Yes	No	0	7	0	1
R:R:F112	R:R:M116	3.73	0	No	No	5	7	2	1
R:R:A115	R:R:F119	4.16	1	No	Yes	5	8	2	1
R:R:F188	R:R:M116	3.73	0	Yes	No	8	7	2	1
L:L:?1	R:R:M116	6.57	1	Yes	No	0	7	0	1
R:R:F118	R:R:F119	7.5	0	Yes	Yes	7	8	2	1
L:L:?1	R:R:F119	4.04	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T123	3.91	1	Yes	No	0	8	0	1
R:R:W186	R:R:Y181	12.54	1	Yes	Yes	7	8	1	2
R:R:F188	R:R:Y181	5.16	0	Yes	Yes	8	8	2	2
R:R:D297	R:R:Y181	9.2	1	No	Yes	6	8	2	2
R:R:P183	R:R:W186	12.16	1	No	Yes	8	7	2	1
R:R:L298	R:R:P183	8.21	1	Yes	No	6	8	1	2
L:L:?1	R:R:T185	5.87	1	Yes	No	0	8	0	1
R:R:D297	R:R:W186	4.47	1	No	Yes	6	7	2	1
R:R:L298	R:R:W186	3.42	1	Yes	Yes	6	7	1	1
R:R:L301	R:R:W186	3.42	0	No	Yes	7	7	2	1
L:L:?1	R:R:W186	10.58	1	Yes	Yes	0	7	0	1
R:R:L298	R:R:R302	12.15	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:L298	4.59	1	Yes	Yes	0	6	0	1
R:R:Q299	R:R:R302	3.5	0	No	Yes	4	8	2	1
L:L:?1	R:R:R302	3.23	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S305	12.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:S308	9.97	1	Yes	No	0	8	0	1
L:L:?1	R:R:I309	3.79	1	Yes	No	0	9	0	1
R:R:I306	R:R:M31	2.92	0	No	No	4	8	2	1
R:R:P87	R:R:S86	1.78	0	No	No	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7CX3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	248
Number of Links	270
Number of Hubs	29
Number of Links mediated by Hubs	122
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	48267
Length Of Smallest Path	3
Average Path Length	12.401
Length of Longest Path	27
Minimum Path Strength	1.315
Average Path Strength	5.7466
Maximum Path Strength	19.185
Minimum Path Correlation	0.7
Average Path Correlation	0.91336
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	46.5481
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.4148
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • response to ketone • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to progesterone • response to oxygen-containing compound • cell population proliferation • regulation of cell population proliferation • defense response • response to stress • inflammatory response • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to external biotic stimulus • response to nematode • response to biotic stimulus • response to lipopolysaccharide • response to bacterium • response to molecule of bacterial origin • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to nitrogen compound • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GNO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	GNO
Name	Taprenepag
Synonyms	Taprenepag
Identifier
Formula	C24 H22 N4 O5 S
Molecular Weight	478.52
SMILES
PubChem	18376177
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	59
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43116
Sequence	>7CX3_nogp_Chain_R E S P A I S S V M F S A G V L G N L I A L A L L A R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N Q T L V A L A P E S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H P Y F Y Q R R V S R S G G L A V L P V I Y A V S L L F C S L P L L D Y G Q Y V Q Y C P G T W C F I R H G R T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M N E T S S R K E K W D L Q A L R F L S I N S I I D P W V F A I L R P P V L R L M R S V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7CX4	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-	Gs/β1/γ2	2.9	2021-05-05	10.1126/sciadv.abf1268
	7CX4 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Evatanepag	-		2.9	2021-05-05	10.1126/sciadv.abf1268
	7CX3	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-	Gs/β1/γ2	2.8	2021-05-05	10.1126/sciadv.abf1268
	7CX3 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	Taprenepag	-		2.8	2021-05-05	10.1126/sciadv.abf1268
	7CX2	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-	Gs/β1/γ2	2.8	2021-05-05	10.1126/sciadv.abf1268
	7CX2 (No Gprot)	A	Lipid	Prostanoid	EP₂	Homo sapiens	PGE2	-		2.8	2021-05-05	10.1126/sciadv.abf1268

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7CX3_nogp.zip

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