psnGPCR

Code	DTY
Name	D-Tyrosine
Synonyms	(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid (R)-3-(p-Hydroxyphenyl)alanine D-Tyr D-Tyrosin D-Tyrosine
Identifier
Formula	C9 H11 N O3
Molecular Weight	181.189
SMILES
PubChem	71098
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6
Networks	9

This ligand is also present in the following 9 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XNA

Peptide

Somatostatin

SST2

Homo Sapiens

CYN154806

2.65

2022-08-03

doi.org/10.1038/s41422-022-00679-x

A 2D representation of the interactions of DTY in 7XNA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?3	L:L:Y4	17.52	1	Yes	No	0	0	2	1
L:L:?3	L:L:C8	8.9	1	Yes	Yes	0	0	2	2
L:L:?9	L:L:Y4	16.84	1	Yes	No	0	0	0	1
L:L:?9	L:L:T7	9.41	1	Yes	No	0	0	0	1
L:L:T7	R:R:D295	4.34	1	No	Yes	0	2	1	1
L:L:C8	R:R:D295	4.67	1	Yes	Yes	0	2	2	1
L:L:?10	L:L:?9	13.74	1	No	Yes	0	0	1	0
L:L:?9	R:R:N43	6.58	1	Yes	Yes	0	3	0	1
L:L:?9	R:R:V103	4.76	1	Yes	Yes	0	4	0	1
L:L:?9	R:R:E106	10.58	1	Yes	No	0	4	0	1
L:L:?9	R:R:D295	6.5	1	Yes	Yes	0	2	0	1
L:L:?10	R:R:N43	10.25	1	No	Yes	0	3	1	1
R:R:N43	R:R:T41	8.77	1	Yes	No	3	4	1	2
R:R:N43	R:R:V103	4.43	1	Yes	Yes	3	4	1	1
R:R:E106	R:R:N43	10.52	1	No	Yes	4	3	1	1
R:R:L46	R:R:Y50	8.21	1	No	Yes	5	7	2	2
R:R:L46	R:R:V103	4.47	1	No	Yes	5	4	2	1
R:R:D295	R:R:L46	6.79	1	Yes	No	2	5	1	2
R:R:V103	R:R:Y50	5.05	1	Yes	Yes	4	7	1	2
L:L:?10	R:R:S42	3.74	1	No	No	0	4	1	2
R:R:T47	R:R:V103	3.17	0	No	Yes	5	4	2	1
L:L:Y4	R:R:S192	2.54	0	No	No	0	4	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	9.77
Average Nodes In Shell	16.00
Average Hubs In Shell	7.00
Average Links In Shell	22.00
Average Links Mediated by Hubs In Shell	20.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8FEG

Peptide

Opioid

KOP

Homo Sapiens

(DNCP)-Beta-Naloxamine

Gi1/Beta1/Gamma2

2.54

2023-12-06

doi.org/10.1038/s41467-023-43718-w

A 2D representation of the interactions of DTY in 8FEG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:Y2	12.29	3	Yes	Yes	0	0	2	1
L:L:?1	L:L:?5	5.74	3	Yes	Yes	0	0	2	1
L:L:?1	L:L:C7	11.88	3	Yes	Yes	0	0	2	2
L:L:?1	R:R:L309	14.51	3	Yes	No	0	4	2	2
L:L:A3	L:L:Y2	8.01	3	No	Yes	0	0	1	1
L:L:?4	L:L:Y2	14.06	3	Yes	Yes	0	0	0	1
L:L:Y2	R:R:F293	5.16	3	Yes	No	0	5	1	2
L:L:Y2	R:R:E297	15.71	3	Yes	No	0	5	1	2
L:L:Y2	R:R:S303	7.63	3	Yes	No	0	1	1	2
L:L:Y2	R:R:S305	7.63	3	Yes	No	0	3	1	1
L:L:Y2	R:R:L309	5.86	3	Yes	No	0	4	1	2
L:L:?4	L:L:A3	10.08	3	Yes	No	0	0	0	1
L:L:?4	L:L:?5	23.5	3	Yes	Yes	0	0	0	1
L:L:?4	R:R:R202	21.37	3	Yes	No	0	2	0	1
L:L:?4	R:R:T302	8.25	3	Yes	No	0	1	0	1
L:L:?4	R:R:S305	6	3	Yes	No	0	3	0	1
L:L:?5	L:L:T6	10.89	3	Yes	No	0	0	1	2
L:L:?5	L:L:C7	8.79	3	Yes	Yes	0	0	1	2
L:L:?5	R:R:R202	15.7	3	Yes	No	0	2	1	1
L:L:?5	R:R:E209	4.89	3	Yes	Yes	0	3	1	2
L:L:T6	R:R:E209	7.06	3	No	Yes	0	3	2	2
R:R:R202	R:R:V207	3.92	3	No	No	2	3	1	2
R:R:E297	R:R:F293	13.99	3	No	No	5	5	2	2
R:R:S305	R:R:T306	1.6	3	No	No	3	2	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	13.88
Average Nodes In Shell	17.00
Average Hubs In Shell	6.00
Average Links In Shell	24.00
Average Links Mediated by Hubs In Shell	21.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XGU

Peptide

Kisspeptin

Kiss1

Homo Sapiens

TAK448

Gi1/Beta1/Gamma2

2024-10-30

doi.org/10.1126/sciadv.adn7771

A 2D representation of the interactions of DTY in 8XGU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	19.89	6	No	Yes	0	0	1	0
L:L:?1	L:L:?3	9.72	6	No	Yes	0	0	1	1
L:L:?1	L:L:T5	4.41	6	No	Yes	0	0	1	1
L:L:?2	L:L:?3	20.76	6	Yes	Yes	0	0	0	1
L:L:?2	L:L:T5	3.54	6	Yes	Yes	0	0	0	1
L:L:?2	R:R:Y299	7.5	6	Yes	No	0	4	0	1
L:L:?2	R:R:Y302	2.81	6	Yes	Yes	0	5	0	1
L:L:?3	L:L:N4	5.15	6	Yes	No	0	0	1	2
L:L:?3	L:L:T5	2.76	6	Yes	Yes	0	0	1	1
L:L:?3	R:R:Y190	11	6	Yes	Yes	0	4	1	2
L:L:N4	R:R:Y190	11.63	6	No	Yes	0	4	2	2
L:L:F6	L:L:T5	9.08	6	Yes	Yes	0	0	2	1
L:L:T5	R:R:Y302	7.49	6	Yes	Yes	0	5	1	1
R:R:D41	R:R:Y302	8.05	0	No	Yes	2	5	2	1
R:R:Y103	R:R:Y302	9.93	6	Yes	Yes	5	5	2	1
R:R:T306	R:R:Y103	3.75	6	No	Yes	4	5	2	2
R:R:T306	R:R:Y302	3.75	6	No	Yes	4	5	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	10.90
Average Nodes In Shell	12.00
Average Hubs In Shell	7.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8ZJE

Peptide

Kisspeptin

Kiss1

Homo Sapiens

TAK-448

chim(NtGi1-Gq)/Beta1/Gamma1

3.07

2024-07-03

doi.org/10.1016/j.celrep.2024.114389

A 2D representation of the interactions of DTY in 8ZJE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?3	R:R:Y190	24.58	1	Yes	No	0	4	1	2
R:R:Y299	R:R:Y302	7.94	0	No	No	4	5	1	2
L:L:?2	R:R:Y299	5.61	1	No	No	0	4	0	1
L:L:T5	R:R:Y302	7.49	0	No	No	0	5	2	2
L:L:?1	L:L:?2	24.1	1	No	No	0	0	1	0
L:L:?1	L:L:?3	3.24	1	No	Yes	0	0	1	1
L:L:?1	L:L:T5	5.67	1	No	No	0	0	1	2
L:L:?2	L:L:?3	24.17	1	No	Yes	0	0	0	1
L:L:?3	L:L:F6	3.33	1	Yes	Yes	0	0	1	2
L:L:?3	L:L:?7	3.25	1	Yes	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.96
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9IK9

Peptide

Somatostatin

SST1

Homo Sapiens

SST analogue

Gi1/Beta1/Gamma2

3.37

2025-04-30

doi.org/10.1016/j.apsb.2025.03.043

A 2D representation of the interactions of DTY in 9IK9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	43.71	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?3	5.33	3	Yes	Yes	0	0	1	0
L:L:?1	L:L:?6	5.11	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?7	2.08	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?8	14.88	3	Yes	Yes	0	0	1	2
L:L:?1	L:L:?9	19.23	3	Yes	Yes	0	0	1	2
L:L:?1	R:R:D300	17.41	3	Yes	No	0	4	1	2
L:L:?2	L:L:?3	16.61	3	Yes	Yes	0	0	1	0
L:L:?2	L:L:?4	3.09	3	Yes	Yes	0	0	1	1
L:L:?2	L:L:?6	5.97	3	Yes	Yes	0	0	1	1
L:L:?2	L:L:?7	18.26	3	Yes	Yes	0	0	1	1
L:L:?2	L:L:?8	3.73	3	Yes	Yes	0	0	1	2
L:L:?2	R:R:D300	15.27	3	Yes	No	0	4	1	2
L:L:?3	L:L:?4	34.27	3	Yes	Yes	0	0	0	1
L:L:?3	L:L:?6	11.21	3	Yes	Yes	0	0	0	1
L:L:?3	L:L:?7	2.08	3	Yes	Yes	0	0	0	1
L:L:?3	R:R:L220	15.5	3	Yes	No	0	5	0	1
L:L:?3	R:R:V224	3.57	3	Yes	No	0	5	0	1
L:L:?3	R:R:Q291	2.13	3	Yes	Yes	0	6	0	1
L:L:?4	L:L:K5	13.43	3	Yes	Yes	0	0	1	2
L:L:?4	L:L:?6	13.15	3	Yes	Yes	0	0	1	1
L:L:?4	L:L:?7	6.18	3	Yes	Yes	0	0	1	1
L:L:?4	R:R:D137	2.15	3	Yes	No	0	6	1	2
L:L:?4	R:R:M141	2.24	3	Yes	Yes	0	7	1	2
L:L:?4	R:R:F223	8.7	3	Yes	No	0	6	1	2
L:L:?4	R:R:F287	4.83	3	Yes	Yes	0	6	1	2
L:L:?4	R:R:Q291	20.07	3	Yes	Yes	0	6	1	1
L:L:?4	R:R:S305	2.38	3	Yes	No	0	4	1	2
L:L:K5	R:R:D137	5.53	3	Yes	No	0	6	2	2
L:L:K5	R:R:F287	4.96	3	Yes	Yes	0	6	2	2
L:L:?6	L:L:?7	22.7	3	Yes	Yes	0	0	1	1
L:L:?6	L:L:?8	15.87	3	Yes	Yes	0	0	1	2
L:L:?6	L:L:?9	3.15	3	Yes	Yes	0	0	1	2
L:L:?6	R:R:N209	12.64	3	Yes	No	0	5	1	2
L:L:?7	L:L:?8	26.11	3	Yes	Yes	0	0	1	2
L:L:?7	L:L:?9	3.21	3	Yes	Yes	0	0	1	2
L:L:?7	R:R:S305	8.45	3	Yes	No	0	4	1	2
L:L:?8	L:L:?9	22.97	3	Yes	Yes	0	0	2	2
R:R:L220	R:R:M210	4.24	0	No	No	5	4	1	2
R:R:A216	R:R:L220	1.58	0	No	No	3	5	2	1
R:R:L225	R:R:V224	2.98	3	No	No	5	5	2	1
R:R:Q291	R:R:V224	5.73	3	Yes	No	6	5	1	1
R:R:F287	R:R:Q291	12.88	3	Yes	Yes	6	6	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	11.34
Average Nodes In Shell	22.00
Average Hubs In Shell	12.00
Average Links In Shell	43.00
Average Links Mediated by Hubs In Shell	40.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	5.33
Average Number Of Links With An Hub	2.67
Average Interaction Strength	13.68
Average Nodes In Shell	14.44
Average Hubs In Shell	6.33
Average Links In Shell	21.78
Average Links Mediated by Hubs In Shell	19.00

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)