psnGPCR

Code	DCY
Name	D-Cysteine
Synonyms	D-Zystein
Identifier
Formula	C3 H7 N O2 S
Molecular Weight	121.158
SMILES
PubChem	6419721
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	1
Total Bonds	13
Total Aromatic Bonds	0
Networks	4

This ligand is also present in the following 4 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3G

Ion

Calcium Sensing

CaS

Homo Sapiens

Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4

2.5

2021-06-30

doi.org/10.1038/s41586-021-03691-0

A 2D representation of the interactions of DCY in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D484	R:R:S175	5.89	2	Yes	No	8	8	2	2
R:R:S175	W:W:?6	5.99	2	No	Yes	8	0	2	1
R:R:N189	W:W:?6	5.47	0	No	Yes	8	0	2	1
R:R:E191	W:W:?6	6.34	2	Yes	Yes	3	0	2	1
R:R:E191	W:W:?7	13.45	2	Yes	Yes	3	0	2	2
R:R:C482	R:R:D480	3.11	2	Yes	No	7	7	1	2
R:R:D480	R:R:D484	7.98	2	No	Yes	7	8	2	2
R:R:D480	W:W:?6	4.33	2	No	Yes	7	0	2	1
R:R:C482	R:R:E481	3.04	2	Yes	No	7	4	1	2
R:R:C482	W:W:?2	11.86	2	Yes	Yes	7	0	1	0
R:R:C482	W:W:?3	3.22	2	Yes	Yes	7	0	1	1
R:R:D484	W:W:?6	6.49	2	Yes	Yes	8	0	2	1
S:S:D248	S:S:E251	14.29	2	No	Yes	3	4	2	2
S:S:D248	W:W:?1	6.11	2	No	Yes	3	0	2	1
S:S:E251	W:W:?1	5.97	2	Yes	Yes	4	0	2	1
S:S:E251	W:W:?4	7.4	2	Yes	Yes	4	0	2	2
S:S:E251	W:W:?5	10.57	2	Yes	Yes	4	0	2	2
W:W:?1	W:W:?2	23.28	2	Yes	Yes	0	0	1	0
W:W:?1	W:W:?3	6.32	2	Yes	Yes	0	0	1	1
W:W:?2	W:W:?3	20.99	2	Yes	Yes	0	0	0	1
W:W:?2	W:W:?6	8.25	2	Yes	Yes	0	0	0	1
W:W:?3	W:W:?4	19.04	2	Yes	Yes	0	0	1	2
W:W:?3	W:W:?5	3.36	2	Yes	Yes	0	0	1	2
W:W:?3	W:W:?6	14.56	2	Yes	Yes	0	0	1	1
W:W:?3	W:W:?7	2.85	2	Yes	Yes	0	0	1	2
W:W:?4	W:W:?5	14.08	2	Yes	Yes	0	0	2	2
W:W:?4	W:W:?6	6.16	2	Yes	Yes	0	0	2	1
W:W:?4	W:W:?7	7.84	2	Yes	Yes	0	0	2	2
W:W:?5	W:W:?6	14.96	2	Yes	Yes	0	0	2	1
W:W:?5	W:W:?7	7.84	2	Yes	Yes	0	0	2	2
W:W:?6	W:W:?7	15.68	2	Yes	Yes	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	16.09
Average Nodes In Shell	16.00
Average Hubs In Shell	11.00
Average Links In Shell	31.00
Average Links Mediated by Hubs In Shell	31.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DCY in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D215	S:S:R172	9.53	1	Yes	Yes	6	4	2	2
R:R:D215	X:X:?5	4.33	1	Yes	Yes	6	0	2	1
R:R:S244	R:R:S247	4.89	1	No	Yes	4	2	2	2
R:R:S244	X:X:?5	4.79	1	No	Yes	4	0	2	1
R:R:E251	R:R:S247	4.31	1	Yes	Yes	4	2	2	2
R:R:S247	X:X:?5	7.18	1	Yes	Yes	2	0	2	1
R:R:D248	R:R:E251	16.89	1	No	Yes	3	4	2	2
R:R:D248	X:X:?1	6.11	1	No	Yes	3	0	2	1
R:R:E251	X:X:?1	5.97	1	Yes	Yes	4	0	2	1
R:R:E251	X:X:?4	6.34	1	Yes	Yes	4	0	2	1
R:R:E251	X:X:?5	12.68	1	Yes	Yes	4	0	2	1
R:R:H254	X:X:?4	7.18	1	No	Yes	3	0	2	1
S:S:E191	S:S:R172	8.14	1	Yes	Yes	3	4	2	2
S:S:R172	X:X:?5	4.84	1	Yes	Yes	4	0	2	1
S:S:R172	X:X:?6	4.84	1	Yes	Yes	4	0	2	1
S:S:R172	X:X:?8	7.75	1	Yes	Yes	4	0	2	2
S:S:D484	S:S:S175	5.89	1	Yes	No	8	8	2	2
S:S:S175	X:X:?6	5.99	1	No	Yes	8	0	2	1
S:S:D484	S:S:N189	5.39	1	Yes	No	8	8	2	2
S:S:N189	X:X:?6	9.85	1	No	Yes	8	0	2	1
S:S:E191	X:X:?6	8.45	1	Yes	Yes	3	0	2	1
S:S:E191	X:X:?7	9.41	1	Yes	Yes	3	0	2	2
S:S:E191	X:X:?8	3.17	1	Yes	Yes	3	0	2	2
S:S:D480	S:S:E481	6.5	1	No	No	7	4	2	2
S:S:D480	S:S:D484	9.31	1	No	Yes	7	8	2	2
S:S:D480	X:X:?6	5.41	1	No	Yes	7	0	2	1
S:S:C482	S:S:E481	3.04	1	Yes	No	7	4	1	2
S:S:C482	S:S:D484	4.67	1	Yes	Yes	7	8	1	2
S:S:C482	X:X:?2	11.86	1	Yes	Yes	7	0	1	0
S:S:C482	X:X:?3	4.83	1	Yes	Yes	7	0	1	1
S:S:C482	X:X:?6	3.8	1	Yes	Yes	7	0	1	1
S:S:D484	X:X:?6	6.49	1	Yes	Yes	8	0	2	1
X:X:?1	X:X:?2	27.17	1	Yes	Yes	0	0	1	0
X:X:?1	X:X:?3	6.32	1	Yes	Yes	0	0	1	1
X:X:?1	X:X:?4	6.63	1	Yes	Yes	0	0	1	1
X:X:?2	X:X:?3	20.99	1	Yes	Yes	0	0	0	1
X:X:?2	X:X:?4	5.16	1	Yes	Yes	0	0	0	1
X:X:?2	X:X:?5	5.16	1	Yes	Yes	0	0	0	1
X:X:?2	X:X:?6	5.16	1	Yes	Yes	0	0	0	1
X:X:?3	X:X:?4	16.8	1	Yes	Yes	0	0	1	1
X:X:?3	X:X:?6	16.8	1	Yes	Yes	0	0	1	1
X:X:?3	X:X:?7	2.85	1	Yes	Yes	0	0	1	2
X:X:?4	X:X:?5	15.84	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?6	6.16	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?7	5.6	1	Yes	Yes	0	0	1	2
X:X:?4	X:X:?8	4.4	1	Yes	Yes	0	0	1	2
X:X:?5	X:X:?6	15.84	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?7	7.84	1	Yes	Yes	0	0	1	2
X:X:?5	X:X:?8	8.8	1	Yes	Yes	0	0	1	2
X:X:?6	X:X:?7	19.04	1	Yes	Yes	0	0	1	2
X:X:?6	X:X:?8	4.4	1	Yes	Yes	0	0	1	2
X:X:?7	X:X:?8	20.16	1	Yes	Yes	0	0	2	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	12.58
Average Nodes In Shell	22.00
Average Hubs In Shell	15.00
Average Links In Shell	52.00
Average Links Mediated by Hubs In Shell	51.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XNA

Peptide

Somatostatin

SST2

Homo Sapiens

CYN154806

2.65

2022-08-03

doi.org/10.1038/s41422-022-00679-x

A 2D representation of the interactions of DCY in 7XNA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	17.78	1	No	Yes	0	0	2	1
L:L:?1	R:R:Y205	12.31	1	No	Yes	0	4	2	2
L:L:?2	L:L:?3	24.15	1	Yes	Yes	0	0	1	0
L:L:?2	L:L:C8	4.94	1	Yes	Yes	0	0	1	1
L:L:?2	R:R:Y205	10.95	1	Yes	Yes	0	4	1	2
L:L:?2	R:R:F275	9.48	1	Yes	No	0	4	1	2
L:L:?2	R:R:M282	4.4	1	Yes	No	0	3	1	2
L:L:?2	R:R:P286	12.78	1	Yes	No	0	2	1	2
L:L:?2	R:R:L290	5.39	1	Yes	No	0	4	1	2
L:L:?2	R:R:F294	11.38	1	Yes	No	0	4	1	2
L:L:?3	L:L:Y4	17.52	1	Yes	No	0	0	0	1
L:L:?3	L:L:C8	8.9	1	Yes	Yes	0	0	0	1
L:L:?3	R:R:K291	3.95	1	Yes	Yes	0	3	0	1
L:L:?9	L:L:Y4	16.84	1	Yes	No	0	0	2	1
L:L:C8	R:R:K291	8.08	1	Yes	Yes	0	3	1	1
L:L:C8	R:R:D295	4.67	1	Yes	Yes	0	2	1	2
L:L:?9	R:R:D295	6.5	1	Yes	Yes	0	2	2	2
R:R:F275	R:R:F294	13.93	1	No	No	4	4	2	2
R:R:K291	R:R:P286	6.69	1	Yes	No	3	2	1	2
L:L:Y4	R:R:S192	2.54	0	No	No	0	4	1	2
R:R:G292	R:R:K291	1.74	0	No	Yes	1	3	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	13.63
Average Nodes In Shell	16.00
Average Hubs In Shell	7.00
Average Links In Shell	21.00
Average Links Mediated by Hubs In Shell	19.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9IK9

Peptide

Somatostatin

SST1

Homo Sapiens

SST analogue

Gi1/Beta1/Gamma2

3.37

2025-04-30

doi.org/10.1016/j.apsb.2025.03.043

A 2D representation of the interactions of DCY in 9IK9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	43.71	3	Yes	Yes	0	0	1	0
L:L:?1	L:L:?3	5.33	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?6	5.11	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?7	2.08	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?8	14.88	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?9	19.23	3	Yes	Yes	0	0	1	2
L:L:?1	R:R:D300	17.41	3	Yes	No	0	4	1	1
L:L:?2	L:L:?3	16.61	3	Yes	Yes	0	0	0	1
L:L:?2	L:L:?4	3.09	3	Yes	Yes	0	0	0	1
L:L:?2	L:L:?6	5.97	3	Yes	Yes	0	0	0	1
L:L:?2	L:L:?7	18.26	3	Yes	Yes	0	0	0	1
L:L:?2	L:L:?8	3.73	3	Yes	Yes	0	0	0	1
L:L:?2	R:R:D300	15.27	3	Yes	No	0	4	0	1
L:L:?3	L:L:?4	34.27	3	Yes	Yes	0	0	1	1
L:L:?3	L:L:?6	11.21	3	Yes	Yes	0	0	1	1
L:L:?3	L:L:?7	2.08	3	Yes	Yes	0	0	1	1
L:L:?3	R:R:L220	15.5	3	Yes	No	0	5	1	2
L:L:?3	R:R:V224	3.57	3	Yes	No	0	5	1	2
L:L:?3	R:R:Q291	2.13	3	Yes	Yes	0	6	1	2
L:L:?4	L:L:K5	13.43	3	Yes	Yes	0	0	1	2
L:L:?4	L:L:?6	13.15	3	Yes	Yes	0	0	1	1
L:L:?4	L:L:?7	6.18	3	Yes	Yes	0	0	1	1
L:L:?4	R:R:D137	2.15	3	Yes	No	0	6	1	2
L:L:?4	R:R:M141	2.24	3	Yes	Yes	0	7	1	2
L:L:?4	R:R:F223	8.7	3	Yes	No	0	6	1	2
L:L:?4	R:R:F287	4.83	3	Yes	Yes	0	6	1	2
L:L:?4	R:R:Q291	20.07	3	Yes	Yes	0	6	1	2
L:L:?4	R:R:S305	2.38	3	Yes	No	0	4	1	2
L:L:K5	R:R:D137	5.53	3	Yes	No	0	6	2	2
L:L:K5	R:R:F287	4.96	3	Yes	Yes	0	6	2	2
L:L:?6	L:L:?7	22.7	3	Yes	Yes	0	0	1	1
L:L:?6	L:L:?8	15.87	3	Yes	Yes	0	0	1	1
L:L:?6	L:L:?9	3.15	3	Yes	Yes	0	0	1	2
L:L:?6	R:R:N209	12.64	3	Yes	No	0	5	1	2
L:L:?7	L:L:?8	26.11	3	Yes	Yes	0	0	1	1
L:L:?7	L:L:?9	3.21	3	Yes	Yes	0	0	1	2
L:L:?7	R:R:S305	8.45	3	Yes	No	0	4	1	2
L:L:?8	L:L:?9	22.97	3	Yes	Yes	0	0	1	2
R:R:Q291	R:R:V224	5.73	3	Yes	No	6	5	2	2
R:R:F287	R:R:Q291	12.88	3	Yes	Yes	6	6	2	2
R:R:D300	R:R:N294	6.73	3	No	No	4	4	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	15.23
Average Nodes In Shell	20.00
Average Hubs In Shell	12.00
Average Links In Shell	41.00
Average Links Mediated by Hubs In Shell	40.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DCY in 9IK9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	43.71	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?3	5.33	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?6	5.11	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?7	2.08	3	Yes	Yes	0	0	1	0
L:L:?1	L:L:?8	14.88	3	Yes	Yes	0	0	1	1
L:L:?1	L:L:?9	19.23	3	Yes	Yes	0	0	1	1
L:L:?1	R:R:D300	17.41	3	Yes	No	0	4	1	2
L:L:?2	L:L:?3	16.61	3	Yes	Yes	0	0	1	1
L:L:?2	L:L:?4	3.09	3	Yes	Yes	0	0	1	1
L:L:?2	L:L:?6	5.97	3	Yes	Yes	0	0	1	1
L:L:?2	L:L:?7	18.26	3	Yes	Yes	0	0	1	0
L:L:?2	L:L:?8	3.73	3	Yes	Yes	0	0	1	1
L:L:?2	R:R:D300	15.27	3	Yes	No	0	4	1	2
L:L:?3	L:L:?4	34.27	3	Yes	Yes	0	0	1	1
L:L:?3	L:L:?6	11.21	3	Yes	Yes	0	0	1	1
L:L:?3	L:L:?7	2.08	3	Yes	Yes	0	0	1	0
L:L:?3	R:R:L220	15.5	3	Yes	No	0	5	1	2
L:L:?3	R:R:V224	3.57	3	Yes	No	0	5	1	2
L:L:?3	R:R:Q291	2.13	3	Yes	Yes	0	6	1	2
L:L:?4	L:L:K5	13.43	3	Yes	Yes	0	0	1	2
L:L:?4	L:L:?6	13.15	3	Yes	Yes	0	0	1	1
L:L:?4	L:L:?7	6.18	3	Yes	Yes	0	0	1	0
L:L:?4	R:R:D137	2.15	3	Yes	No	0	6	1	2
L:L:?4	R:R:M141	2.24	3	Yes	Yes	0	7	1	2
L:L:?4	R:R:F223	8.7	3	Yes	No	0	6	1	2
L:L:?4	R:R:F287	4.83	3	Yes	Yes	0	6	1	2
L:L:?4	R:R:Q291	20.07	3	Yes	Yes	0	6	1	2
L:L:?4	R:R:S305	2.38	3	Yes	No	0	4	1	1
L:L:K5	R:R:D137	5.53	3	Yes	No	0	6	2	2
L:L:K5	R:R:F287	4.96	3	Yes	Yes	0	6	2	2
L:L:?6	L:L:?7	22.7	3	Yes	Yes	0	0	1	0
L:L:?6	L:L:?8	15.87	3	Yes	Yes	0	0	1	1
L:L:?6	L:L:?9	3.15	3	Yes	Yes	0	0	1	1
L:L:?6	R:R:N209	12.64	3	Yes	No	0	5	1	2
L:L:?7	L:L:?8	26.11	3	Yes	Yes	0	0	0	1
L:L:?7	L:L:?9	3.21	3	Yes	Yes	0	0	0	1
L:L:?7	R:R:S305	8.45	3	Yes	No	0	4	0	1
L:L:?8	L:L:?9	22.97	3	Yes	Yes	0	0	1	1
R:R:Q291	R:R:V224	5.73	3	Yes	No	6	5	2	2
R:R:F287	R:R:Q291	12.88	3	Yes	Yes	6	6	2	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	11.13
Average Nodes In Shell	19.00
Average Hubs In Shell	12.00
Average Links In Shell	40.00
Average Links Mediated by Hubs In Shell	40.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	5.29
Average Interaction Strength	14.01
Average Nodes In Shell	18.00
Average Hubs In Shell	11.00
Average Links In Shell	35.57
Average Links Mediated by Hubs In Shell	34.71

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)