psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I128	R:R:M123	4.37	No	No	0	2	3
2	R:R:M123	R:R:Q131	8.16	No	No	0	3	3
3	R:R:D124	R:R:E127	3.9	No	No	0	2	1
4	R:R:E127	R:R:V130	4.28	No	No	0	1	1
5	R:R:E133	R:R:K136	8.1	No	No	0	2	2
6	R:R:F141	R:R:M137	7.46	No	No	0	6	4
7	R:R:F383	R:R:Y138	8.25	No	No	0	5	5
8	R:R:F141	R:R:M144	6.22	No	No	0	6	6
9	R:R:F141	R:R:F383	7.5	No	No	0	6	5
10	R:R:F387	R:R:M144	4.98	No	No	0	5	6
11	R:R:T146	R:R:Y145	4.99	No	No	1	7	7
12	R:R:Y145	R:R:Y149	3.97	No	Yes	1	7	8
13	R:R:D195	R:R:Y145	5.75	Yes	No	1	7	7
14	R:R:D195	R:R:T146	7.23	Yes	No	1	7	7
15	R:R:G148	R:R:S390	3.71	No	No	1	7	9
16	R:R:F391	R:R:G148	9.03	No	No	1	7	7
17	R:R:K187	R:R:Y149	5.97	No	Yes	1	8	8
18	R:R:A188	R:R:Y149	4	No	Yes	0	8	8
19	R:R:V191	R:R:Y149	12.62	No	Yes	0	7	8
20	R:R:S389	R:R:Y149	3.82	No	Yes	1	6	8
21	R:R:S390	R:R:Y149	6.36	No	Yes	1	9	8
22	R:R:G393	R:R:S152	3.71	No	No	0	9	9
23	R:R:L153	R:R:L157	6.92	No	No	0	6	3
24	R:R:G154	R:R:L157	5.13	No	No	0	4	3
25	R:R:F181	R:R:L156	3.65	No	Yes	0	8	8
26	R:R:G393	R:R:L156	5.13	No	Yes	0	9	8
27	R:R:F402	R:R:L158	6.09	No	No	0	9	5
28	R:R:A159	R:R:C401	3.61	No	Yes	0	9	9
29	R:R:F181	R:R:L160	7.31	No	No	0	8	6
30	R:R:K168	R:R:L163	4.23	No	No	0	8	8
31	R:R:K168	R:R:L166	7.05	No	No	0	8	7
32	R:R:L166	R:R:R414	10.93	No	No	0	7	5
33	R:R:E410	R:R:S167	7.19	Yes	No	0	8	8
34	R:R:K168	R:R:N174	8.39	No	No	0	8	9
35	R:R:H170	R:R:L169	7.71	No	No	0	7	9
36	R:R:C171	R:R:N174	11.02	No	No	0	7	9
37	R:R:N174	R:R:R173	7.23	No	Yes	0	9	9
38	R:R:H177	R:R:R173	7.9	No	Yes	3	9	9
39	R:R:N404	R:R:R173	4.82	Yes	Yes	3	9	9
40	R:R:E406	R:R:R173	6.98	Yes	Yes	3	9	9
41	R:R:I176	R:R:V244	6.14	No	No	0	9	8
42	R:R:E245	R:R:I176	8.2	Yes	No	0	9	9
43	R:R:I176	R:R:L268	4.28	No	No	0	9	5
44	R:R:E245	R:R:H177	13.54	Yes	No	3	9	9
45	R:R:H177	R:R:Y400	16.33	No	Yes	3	9	8
46	R:R:N179	R:R:W241	16.95	No	Yes	4	8	9
47	R:R:N179	R:R:W272	5.65	No	No	4	8	9
48	R:R:F184	R:R:L180	3.65	Yes	No	0	8	9
49	R:R:E245	R:R:L180	3.98	Yes	No	0	9	9
50	R:R:F181	R:R:V396	3.93	No	No	0	8	9
51	R:R:F184	R:R:S183	3.96	Yes	No	0	8	9
52	R:R:F184	R:R:N238	14.5	Yes	No	0	8	9
53	R:R:F184	R:R:Q392	5.86	Yes	Yes	0	8	9
54	R:R:F184	R:R:G393	4.52	Yes	No	0	8	9
55	R:R:F184	R:R:V396	3.93	Yes	No	0	8	9
56	R:R:K187	R:R:N238	4.2	No	No	0	8	9
57	R:R:K187	R:R:S389	4.59	No	No	1	8	6
58	R:R:F230	R:R:S190	5.28	No	No	0	4	5
59	R:R:M231	R:R:S190	4.6	No	No	0	6	5
60	R:R:M231	R:R:V191	4.56	No	No	0	6	7
61	R:R:I194	R:R:W295	8.22	Yes	No	0	6	9
62	R:R:C224	R:R:L197	4.76	No	No	0	9	4
63	R:R:C224	R:R:C294	5.46	No	No	5	9	9
64	R:R:C287	R:R:R225	8.36	No	No	0	3	8
65	R:R:N291	R:R:R225	4.82	No	No	0	6	8
66	R:R:M231	R:R:W295	10.47	No	No	0	6	9
67	R:R:F303	R:R:Q232	4.68	Yes	No	2	4	7
68	R:R:L307	R:R:Q232	5.32	Yes	No	2	7	7
69	R:R:W272	R:R:Y233	4.82	No	Yes	0	9	9
70	R:R:M276	R:R:Y233	5.99	No	Yes	0	3	9
71	R:R:P275	R:R:V236	5.3	Yes	Yes	0	9	6
72	R:R:V236	R:R:V279	6.41	Yes	No	2	6	6
73	R:R:P310	R:R:V236	5.3	No	Yes	2	9	6
74	R:R:V236	R:R:V311	4.81	Yes	No	0	6	8
75	R:R:A237	R:R:P275	3.74	No	Yes	0	7	9
76	R:R:N238	R:R:Y239	4.65	No	Yes	0	9	8
77	R:R:L242	R:R:Y239	3.52	No	Yes	0	9	8
78	R:R:L358	R:R:Y239	4.69	No	Yes	0	9	8
79	R:R:G359	R:R:Y239	4.35	No	Yes	0	9	8
80	R:R:E362	R:R:Y239	4.49	Yes	Yes	0	8	8
81	R:R:C240	R:R:W241	5.22	No	Yes	0	6	9
82	R:R:C240	R:R:P275	7.53	No	Yes	0	6	9
83	R:R:V244	R:R:W241	6.13	No	Yes	0	8	9
84	R:R:W241	R:R:W272	14.06	Yes	No	4	9	9
85	R:R:I355	R:R:L242	4.28	Yes	No	0	8	9
86	R:R:L243	R:R:L247	5.54	No	No	0	8	7
87	R:R:I317	R:R:L243	5.71	No	No	0	6	8
88	R:R:L243	R:R:N318	10.98	No	No	0	8	9
89	R:R:V244	R:R:Y248	7.57	No	No	0	8	8
90	R:R:E245	R:R:Y400	14.59	Yes	Yes	3	9	8
91	R:R:F264	R:R:Y248	17.54	No	No	0	6	8
92	R:R:I325	R:R:L249	4.28	No	Yes	0	9	9
93	R:R:K344	R:R:L249	7.05	Yes	Yes	0	6	9
94	R:R:L249	R:R:L347	4.15	Yes	No	0	9	9
95	R:R:L249	R:R:T351	5.9	Yes	No	0	9	9
96	R:R:H250	R:R:N251	6.38	Yes	No	0	7	7
97	R:R:H250	R:R:R324	6.77	Yes	No	0	7	8
98	R:R:H250	R:R:I325	3.98	Yes	No	0	7	9
99	R:R:L252	R:R:L253	4.15	No	No	0	8	8
100	R:R:L252	R:R:R261	3.64	No	No	0	8	5
101	R:R:L253	R:R:Y343	7.03	No	No	0	8	7
102	R:R:K344	R:R:L253	15.51	Yes	No	0	6	8
103	R:R:L255	R:R:L258	5.54	No	No	0	5	6
104	R:R:E260	R:R:F264	11.66	No	No	0	6	6
105	R:R:L266	R:R:Y267	5.86	No	No	0	3	7
106	R:R:I270	R:R:Y267	4.84	No	No	0	7	7
107	R:R:G271	R:R:I270	3.53	No	No	0	9	7
108	R:R:M276	R:R:V280	9.13	No	No	0	3	2
109	R:R:F278	R:R:L277	4.87	No	No	0	5	4
110	R:R:F278	R:R:W282	10.02	No	No	0	5	9
111	R:R:F278	R:R:F309	10.72	No	No	0	5	4
112	R:R:I306	R:R:V279	4.61	Yes	No	2	8	6
113	R:R:P310	R:R:V279	3.53	No	No	2	9	6
114	R:R:P281	R:R:V280	3.53	No	No	0	4	2
115	R:R:P281	R:R:W282	9.46	No	No	0	4	9
116	R:R:W282	R:R:W305	13.12	No	No	0	9	7
117	R:R:A283	R:R:I306	4.87	No	Yes	0	5	8
118	R:R:F289	R:R:K286	8.69	No	No	0	3	8
119	R:R:E290	R:R:F289	8.16	No	No	0	6	3
120	R:R:Q293	R:R:V292	8.6	No	No	0	4	4
121	R:R:D299	R:R:T296	4.34	Yes	No	2	4	5
122	R:R:F303	R:R:T296	10.38	Yes	No	2	4	5
123	R:R:D299	R:R:F303	7.17	Yes	Yes	2	4	4
124	R:R:F303	R:R:I306	8.79	Yes	Yes	2	4	8
125	R:R:F303	R:R:L307	4.87	Yes	Yes	2	4	7
126	R:R:R308	R:R:W304	11	No	No	0	6	6
127	R:R:I306	R:R:L307	4.28	Yes	Yes	2	8	7
128	R:R:L307	R:R:R308	3.64	Yes	No	0	7	6
129	R:R:A366	R:R:R308	5.53	No	No	0	7	6
130	R:R:F309	R:R:P310	10.11	No	No	0	4	9
131	R:R:G359	R:R:I315	3.53	No	No	0	9	7
132	R:R:I315	R:R:V363	6.14	No	No	0	7	6
133	R:R:F320	R:R:L316	3.65	No	No	0	5	3
134	R:R:I355	R:R:N318	11.33	Yes	No	0	8	9
135	R:R:F319	R:R:F320	9.65	No	No	0	7	5
136	R:R:F319	R:R:V323	3.93	No	No	0	7	5
137	R:R:F322	R:R:I355	5.02	No	Yes	0	9	8
138	R:R:K332	R:R:Q337	12.2	No	No	0	9	7
139	R:R:K332	R:R:M338	11.52	No	Yes	0	9	5
140	R:R:D342	R:R:M338	5.54	No	Yes	6	7	5
141	R:R:K344	R:R:M338	5.76	Yes	Yes	6	6	5
142	R:R:H339	R:R:H340	7.17	No	No	0	4	5
143	R:R:H339	R:R:T341	9.58	No	No	0	4	6
144	R:R:D342	R:R:Y343	4.6	No	No	0	7	7
145	R:R:D342	R:R:K344	4.15	No	Yes	6	7	6
146	R:R:N404	R:R:R346	7.23	Yes	No	3	9	8
147	R:R:K405	R:R:R346	8.66	No	No	0	6	8
148	R:R:E406	R:R:R346	4.65	Yes	No	3	9	8
149	R:R:L399	R:R:S350	4.5	No	No	0	8	9
150	R:R:S350	R:R:Y400	6.36	No	Yes	0	9	8
151	R:R:T351	R:R:Y400	7.49	No	Yes	0	9	8
152	R:R:L354	R:R:V396	7.45	No	No	0	9	9
153	R:R:L354	R:R:Y400	4.69	No	Yes	0	9	8
154	R:R:I355	R:R:P356	5.08	Yes	No	0	8	9
155	R:R:L358	R:R:Q392	9.32	No	Yes	0	9	9
156	R:R:E362	R:R:H361	9.85	Yes	No	1	8	8
157	R:R:H361	R:R:L388	7.71	No	No	0	8	6
158	R:R:H361	R:R:Q392	11.13	No	Yes	1	8	9
159	R:R:E362	R:R:F365	9.33	Yes	No	0	8	7
160	R:R:E362	R:R:S389	7.19	Yes	No	1	8	6
161	R:R:E362	R:R:Q392	6.37	Yes	Yes	1	8	9
162	R:R:V364	R:R:V368	11.22	No	No	0	6	5
163	R:R:D385	R:R:F365	15.52	No	No	0	7	7
164	R:R:D370	R:R:F367	22.69	No	No	0	4	5
165	R:R:L377	R:R:Q374	9.32	No	No	0	3	4
166	R:R:L382	R:R:L386	4.15	No	No	0	5	7
167	R:R:F384	R:R:L388	4.87	No	No	0	4	6
168	R:R:F391	R:R:S390	6.61	No	No	1	7	9
169	R:R:L395	R:R:L399	8.3	No	No	0	6	8
170	R:R:C401	R:R:F402	4.19	Yes	No	0	9	9
171	R:R:E406	R:R:N404	6.57	Yes	Yes	3	9	9
172	R:R:N404	R:R:V407	7.39	Yes	No	0	9	9
173	R:R:E410	R:R:R413	11.63	Yes	No	0	8	7
174	R:R:E410	R:R:R414	4.65	Yes	No	0	8	5
175	R:R:R413	R:R:R417	5.33	No	No	0	7	7
176	R:R:H416	R:R:W415	8.46	No	No	0	3	5
177	R:R:R419	R:R:W415	14.99	No	No	0	5	5
178	R:R:K422	R:R:W418	9.28	No	No	0	5	3
179	R:R:L420	R:R:L424	6.92	No	No	0	4	4
180	R:R:E426	R:R:W425	4.36	No	No	0	4	2
181	R:R:R428	R:R:W425	7	No	No	7	2	2
182	R:R:N429	R:R:W425	9.04	No	No	7	5	2
183	R:R:N429	R:R:R428	6.03	No	No	7	5	2
184	R:R:G302	R:R:K286	3.49	No	No	0	2	8
185	R:R:G254	R:R:L328	3.42	No	No	0	6	8
186	R:R:A227	R:R:V193	3.39	No	No	0	6	5
187	R:R:L258	R:R:P259	3.28	No	No	0	6	6
188	R:R:C401	R:R:I162	3.27	Yes	No	0	9	8
189	R:R:S217	R:R:V221	3.23	No	No	0	4	4
190	R:R:V280	R:R:V284	3.21	No	No	0	2	4
191	R:R:A348	R:R:K344	3.21	No	Yes	0	7	6
192	R:R:S262	R:R:T172	3.2	No	No	0	5	7
193	R:R:C401	R:R:L163	3.17	Yes	No	0	9	8
194	R:R:T369	R:R:V368	3.17	No	No	0	7	5
195	R:R:A397	R:R:L156	3.15	No	Yes	0	8	8
196	R:R:A222	R:R:D218	3.09	No	No	0	4	4
197	R:R:I235	R:R:V236	3.07	No	Yes	0	5	6
198	R:R:L192	R:R:S150	3	No	No	0	7	7
199	R:R:L394	R:R:S152	3	No	No	0	5	9
200	R:R:L151	R:R:V147	2.98	No	No	0	5	5
201	R:R:L156	R:R:V185	2.98	Yes	No	0	8	8
202	R:R:L157	R:R:V185	2.98	No	No	0	3	8
203	R:R:L394	R:R:V398	2.98	No	No	0	5	6
204	R:R:L403	R:R:V398	2.98	No	No	0	5	6
205	R:R:L258	R:R:T257	2.95	No	No	0	6	7
206	R:R:L377	R:R:T376	2.95	No	No	0	3	2
207	R:R:G234	R:R:Y233	2.9	No	Yes	0	5	9
208	R:R:I162	R:R:L411	2.85	No	No	0	8	5
209	R:R:I194	R:R:L198	2.85	Yes	No	0	6	6
210	R:R:I321	R:R:L247	2.85	No	No	0	8	7
211	R:R:G269	R:R:W241	2.81	No	Yes	0	4	9
212	R:R:D385	R:R:K381	2.77	No	No	0	7	7
213	R:R:E129	R:R:K132	2.7	No	No	0	1	2
214	R:R:A314	R:R:Y239	2.67	No	Yes	0	8	8
215	R:R:F383	R:R:S379	2.64	No	No	0	5	3
216	R:R:D195	R:R:Q142	2.61	Yes	No	0	7	5
217	R:R:V134	R:R:Y138	2.52	No	No	0	2	5
218	R:R:F312	R:R:I315	2.51	No	No	0	5	7
219	R:R:F345	R:R:M338	2.49	No	Yes	0	7	5
220	R:R:F322	R:R:L352	2.44	No	No	0	9	8
221	R:R:F345	R:R:L329	2.44	No	No	0	7	9
222	R:R:L186	R:R:Y233	2.34	No	Yes	0	7	9
223	R:R:E260	R:R:F263	2.33	No	No	0	6	5
224	R:R:M301	R:R:W305	2.33	No	No	0	5	7
225	R:R:H416	R:R:R412	2.26	No	No	0	3	5
226	R:R:F387	R:R:F391	2.14	No	No	0	5	7
227	R:R:R334	R:R:R336	2.13	No	No	0	7	5
228	R:R:G164	R:R:G165	2.11	No	No	0	3	3
229	R:R:G273	R:R:P275	2.03	No	Yes	0	6	9
230	R:R:A274	R:R:P275	1.87	No	Yes	0	4	9
231	R:R:G223	R:R:V226	1.84	No	No	0	3	4
232	R:R:A155	R:R:A397	1.79	No	No	0	6	8
233	R:R:P281	R:R:V285	1.77	No	No	0	4	5
234	R:R:G125	R:R:I128	1.76	No	No	0	2	2
235	R:R:G246	R:R:I321	1.76	No	No	0	9	8
236	R:R:G269	R:R:I270	1.76	No	No	0	4	7
237	R:R:G165	R:R:L166	1.71	No	No	0	3	7
238	R:R:G165	R:R:L169	1.71	No	No	0	3	9
239	R:R:D124	R:R:G125	1.68	No	No	0	2	2
240	R:R:D195	R:R:G196	1.68	Yes	No	0	7	3
241	R:R:D299	R:R:G302	1.68	Yes	No	0	4	2
242	R:R:C224	R:R:I194	1.64	No	Yes	5	9	6
243	R:R:C294	R:R:I194	1.64	No	Yes	5	9	6
244	R:R:G375	R:R:Q374	1.64	No	No	0	2	4
245	R:R:S139	R:R:S140	1.63	No	No	0	3	4
246	R:R:S189	R:R:S190	1.63	No	No	0	4	5
247	R:R:A227	R:R:I194	1.62	No	Yes	0	6	6
248	R:R:A228	R:R:I194	1.62	No	Yes	0	5	6
249	R:R:A331	R:R:K332	1.61	No	No	0	7	9
250	R:R:V130	R:R:V134	1.6	No	No	0	1	2
251	R:R:S150	R:R:T146	1.6	No	No	0	7	7
252	R:R:V229	R:R:V284	1.6	No	No	0	6	4
253	R:R:V360	R:R:V364	1.6	No	No	0	6	6
254	R:R:A178	R:R:L160	1.58	No	No	0	7	6
255	R:R:A220	R:R:L197	1.58	No	No	0	6	4
256	R:R:K136	R:R:S139	1.53	No	No	0	2	3
257	R:R:A373	R:R:Q374	1.52	No	No	0	3	4
258	R:R:A373	R:R:E371	1.51	No	No	0	3	5
259	R:R:K405	R:R:T341	1.5	No	No	0	6	6
260	R:R:K381	R:R:T369	1.5	No	No	0	7	7
261	R:R:G375	R:R:R378	1.5	No	No	0	2	4
262	R:R:L352	R:R:V326	1.49	No	No	0	8	7
263	R:R:L197	R:R:T200	1.47	No	No	0	4	3
264	R:R:D299	R:R:S297	1.47	Yes	No	0	4	4
265	R:R:L352	R:R:T353	1.47	No	No	0	8	8
266	R:R:L399	R:R:T353	1.47	No	No	0	8	8
267	R:R:D218	R:R:V221	1.46	No	No	0	4	4
268	R:R:Q142	R:R:S139	1.44	No	No	0	5	3
269	R:R:Q293	R:R:S297	1.44	No	No	0	4	4
270	R:R:E406	R:R:S409	1.44	Yes	No	0	9	4
271	R:R:E410	R:R:S409	1.44	Yes	No	0	8	4
272	R:R:L357	R:R:L395	1.38	No	No	0	9	6
273	R:R:E129	R:R:I128	1.37	No	No	0	1	2
274	R:R:N298	R:R:N300	1.36	No	No	0	6	5
275	R:R:E427	R:R:L424	1.33	No	No	0	5	4
276	R:R:F322	R:R:V323	1.31	No	No	0	9	5
277	R:R:H250	R:R:L328	1.29	Yes	No	0	7	8
278	R:R:F345	R:R:K349	1.24	No	No	0	7	9
279	R:R:E371	R:R:H372	1.23	No	No	0	5	4
280	R:R:N300	R:R:W304	1.13	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y149	6.12333	6	1	8
2	R:R:L156	3.7275	4	0	8
3	R:R:R173	6.7325	4	3	9
4	R:R:F184	6.07	6	0	8
5	R:R:I194	2.93167	6	5	6
6	R:R:D195	4.3175	4	1	7
7	R:R:Y233	4.0125	4	0	9
8	R:R:V236	4.978	5	2	6
9	R:R:Y239	4.06167	6	0	8
10	R:R:W241	9.034	5	4	9
11	R:R:E245	10.0775	4	3	9
12	R:R:L249	5.345	4	0	9
13	R:R:H250	4.605	4	0	7
14	R:R:P275	4.094	5	0	9
15	R:R:D299	3.665	4	2	4
16	R:R:F303	7.178	5	2	4
17	R:R:I306	5.6375	4	2	8
18	R:R:L307	4.5275	4	2	7
19	R:R:M338	6.3275	4	6	5
20	R:R:K344	7.136	5	6	6
21	R:R:I355	6.4275	4	0	8
22	R:R:E362	7.446	5	1	8
23	R:R:Q392	8.17	4	1	9
24	R:R:Y400	9.892	5	3	8
25	R:R:C401	3.56	4	0	9
26	R:R:N404	6.5025	4	3	9
27	R:R:E406	4.91	4	3	9
28	R:R:E410	6.2275	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D124	R:R:G125	14.1629	1.68	No	No	0	2	2
2	R:R:G125	R:R:I128	11.8428	1.76	No	No	0	2	2
3	R:R:D124	R:R:E127	16.4664	3.9	No	No	0	2	1
4	R:R:E127	R:R:V130	18.7531	4.28	No	No	0	1	1
5	R:R:D195	R:R:Q142	11.8428	2.61	Yes	No	0	7	5
6	R:R:D195	R:R:Y145	16.2911	5.75	Yes	No	1	7	7
7	R:R:Y145	R:R:Y149	25.5133	3.97	No	Yes	1	7	8
8	R:R:S390	R:R:Y149	44.8506	6.36	No	Yes	1	9	8
9	R:R:F391	R:R:S390	40.5108	6.61	No	No	1	7	9
10	R:R:F387	R:R:F391	38.5411	2.14	No	No	0	5	7
11	R:R:F387	R:R:M144	36.4046	4.98	No	No	0	5	6
12	R:R:F141	R:R:M144	34.2514	6.22	No	No	0	6	6
13	R:R:F141	R:R:F383	29.8948	7.5	No	No	0	6	5
14	R:R:F383	R:R:Y138	25.4632	8.25	No	No	0	5	5
15	R:R:V134	R:R:Y138	23.2265	2.52	No	No	0	2	5
16	R:R:V130	R:R:V134	21.0232	1.6	No	No	0	1	2
17	R:R:K187	R:R:Y149	82.5655	5.97	No	Yes	1	8	8
18	R:R:V191	R:R:Y149	36.4463	12.62	No	Yes	0	7	8
19	R:R:S389	R:R:Y149	15.5233	3.82	No	Yes	1	6	8
20	R:R:F184	R:R:G393	21.5073	4.52	Yes	No	0	8	9
21	R:R:F184	R:R:N238	95.2011	14.5	Yes	No	0	8	9
22	R:R:K187	R:R:N238	85.3196	4.2	No	No	0	8	9
23	R:R:G393	R:R:L156	11.4505	5.13	No	Yes	0	9	8
24	R:R:F181	R:R:V396	11.2001	3.93	No	No	0	8	9
25	R:R:F184	R:R:V396	25.0292	3.93	Yes	No	0	8	9
26	R:R:C401	R:R:L163	12.2601	3.17	Yes	No	0	9	8
27	R:R:K168	R:R:L163	14.2464	4.23	No	No	0	8	8
28	R:R:K168	R:R:N174	26.9905	8.39	No	No	0	8	9
29	R:R:N174	R:R:R173	30.5959	7.23	No	Yes	0	9	9
30	R:R:H177	R:R:R173	64.5218	7.9	No	Yes	3	9	9
31	R:R:E245	R:R:H177	48.4059	13.54	Yes	No	3	9	9
32	R:R:E245	R:R:L180	100	3.98	Yes	No	0	9	9
33	R:R:F184	R:R:L180	99.783	3.65	Yes	No	0	8	9
34	R:R:K168	R:R:L166	12.235	7.05	No	No	0	8	7
35	R:R:E406	R:R:R173	22.4754	6.98	Yes	Yes	3	9	9
36	R:R:E406	R:R:S409	11.559	1.44	Yes	No	0	9	4
37	R:R:N404	R:R:R173	13.4869	4.82	Yes	Yes	3	9	9
38	R:R:E245	R:R:I176	90.1269	8.2	Yes	No	0	9	9
39	R:R:I176	R:R:V244	88.0905	6.14	No	No	0	9	8
40	R:R:E245	R:R:Y400	40.8947	14.59	Yes	Yes	3	9	8
41	R:R:L354	R:R:V396	28.4427	7.45	No	No	0	9	9
42	R:R:L354	R:R:Y400	28.7431	4.69	No	Yes	0	9	8
43	R:R:V244	R:R:W241	82.7074	6.13	No	Yes	0	8	9
44	R:R:W241	R:R:W272	22.3252	14.06	Yes	No	4	9	9
45	R:R:E362	R:R:S389	17.0172	7.19	Yes	No	1	8	6
46	R:R:E362	R:R:Q392	14.3799	6.37	Yes	Yes	1	8	9
47	R:R:M231	R:R:V191	34.2931	4.56	No	No	0	6	7
48	R:R:M231	R:R:W295	25.5133	10.47	No	No	0	6	9
49	R:R:I194	R:R:W295	23.2766	8.22	Yes	No	0	6	9
50	R:R:F303	R:R:I306	20.464	8.79	Yes	Yes	2	4	8
51	R:R:I306	R:R:V279	36.8803	4.61	Yes	No	2	8	6
52	R:R:V236	R:R:V279	36.2711	6.41	Yes	No	2	6	6
53	R:R:P275	R:R:V236	47.7299	5.3	Yes	Yes	0	9	6
54	R:R:C240	R:R:P275	53.4051	7.53	No	Yes	0	6	9
55	R:R:C240	R:R:W241	54.8156	5.22	No	Yes	0	6	9
56	R:R:I306	R:R:L307	13.0195	4.28	Yes	Yes	2	8	7
57	R:R:W272	R:R:Y233	20.6894	4.82	No	Yes	0	9	9
58	R:R:M276	R:R:Y233	15.3564	5.99	No	Yes	0	3	9
59	R:R:N238	R:R:Y239	29.1187	4.65	No	Yes	0	9	8
60	R:R:E362	R:R:Y239	12.6773	4.49	Yes	Yes	0	8	8
61	R:R:L242	R:R:Y239	27.8668	3.52	No	Yes	0	9	8
62	R:R:G359	R:R:Y239	10.2404	4.35	No	Yes	0	9	8
63	R:R:I355	R:R:L242	25.6218	4.28	Yes	No	0	8	9
64	R:R:I355	R:R:N318	15.8154	11.33	Yes	No	0	8	9
65	R:R:L243	R:R:N318	13.2198	10.98	No	No	0	8	9
66	R:R:T351	R:R:Y400	58.4794	7.49	No	Yes	0	9	8
67	R:R:L249	R:R:T351	56.2344	5.9	Yes	No	0	9	9
68	R:R:I325	R:R:L249	15.5149	4.28	No	Yes	0	9	9
69	R:R:K344	R:R:L249	37.6732	7.05	Yes	Yes	0	6	9
70	R:R:H250	R:R:I325	12.9695	3.98	Yes	No	0	7	9
71	R:R:K344	R:R:L253	10.3071	15.51	Yes	No	0	6	8
72	R:R:M276	R:R:V280	13.7373	9.13	No	No	0	3	2
73	R:R:D299	R:R:F303	15.4148	7.17	Yes	Yes	2	4	4
74	R:R:F322	R:R:I355	14.5385	5.02	No	Yes	0	9	8
75	R:R:K344	R:R:M338	17.8685	5.76	Yes	Yes	6	6	5
76	R:R:K405	R:R:T341	11.9596	1.5	No	No	0	6	6
77	R:R:K405	R:R:R346	15.9155	8.66	No	No	0	6	8
78	R:R:E406	R:R:R346	10.0985	4.65	Yes	No	3	9	8
79	R:R:S350	R:R:Y400	22.3585	6.36	No	Yes	0	9	8
80	R:R:L399	R:R:S350	20.0718	4.5	No	No	0	8	9
81	R:R:E362	R:R:F365	15.2395	9.33	Yes	No	0	8	7
82	R:R:D385	R:R:F365	13.1113	15.52	No	No	0	7	7
83	R:R:D385	R:R:K381	10.9664	2.77	No	No	0	7	7
84	R:R:F322	R:R:L352	13.7873	2.44	No	No	0	9	8
85	R:R:L352	R:R:T353	13.6538	1.47	No	No	0	8	8
86	R:R:F184	R:R:Q392	20.5809	5.86	Yes	Yes	0	8	9
87	R:R:L399	R:R:T353	13.8124	1.47	No	No	0	8	8
88	R:R:H177	R:R:Y400	17.5931	16.33	No	Yes	3	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 4L6R

PDB Summary
PDB	4L6R
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	Glucagon
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.3
Date	2013-07-24
D.O.I.	doi.org/10.1038/nature12393

Net Summary
I_min	3.52
Number of Linked Nodes	271
Number of Links	280
Number of Hubs	28
Number of Links mediated by Hubs	113
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	31754
Length Of Smallest Path	3
Average Path Length	13.2273
Length of Longest Path	35
Minimum Path Strength	1.245
Average Path Strength	6.24321
Maximum Path Strength	14.6
Minimum Path Correlation	0.7
Average Path Correlation	0.954158
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	65.4014
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.7974
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • regulation of biosynthetic process • regulation of biological process • regulation of cellular process
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to nutrient levels • response to nutrient levels • cellular response to stress • response to stress • response to starvation • cellular response to starvation • cell surface receptor signaling pathway • response to nutrient • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • cellular anatomical structure • periplasmic space • membrane • cell periphery • plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes • G protein-coupled receptor-like
SCOP2	Family Identifier	• Cytochromes • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>4L6R_Chain_R M D G E E I E V Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T L S D G A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L A T L P E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N D N M G F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H H T D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D E H A Q G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H R W R L G K V L W E E R N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/β1/γ2	2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG8 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide		2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	doi.org/10.1038/nature22363
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	doi.org/10.1038/nature22363
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	doi.org/10.1038/nature17414
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	8FU6 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	doi.org/10.1038/nature12393
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon analogue	-	-	3	2018-01-17	doi.org/10.1038/nature25153
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V35 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-		3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/β1/γ2	2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIT (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-		2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/β1/γ2	3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIQ (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-		3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/β1/γ2	2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-		2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/β1/γ2	3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LMK (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gi1/β1/γ1	3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	3.1	2020-08-12	doi.org/10.1126/science.aba3373
	6WPW (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		3.1	2020-08-12	doi.org/10.1126/science.aba3373
	8YW5	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-		2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4L6R.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.