Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y149 6.12333618
2R:R:L156 3.7275408
3R:R:K168 5.725428
4R:R:R173 6.7325429
5R:R:F181 4.495408
6R:R:F184 6.07618
7R:R:K187 5.145418
8R:R:I194 2.04833656
9R:R:D195 4.3175417
10R:R:M231 3.6025406
11R:R:Y233 4.0125409
12R:R:V236 4.978576
13R:R:N238 6.5825419
14R:R:Y239 4.06167608
15R:R:W241 8.09833649
16R:R:E245 10.0775429
17R:R:H250 4.605407
18R:R:P275 4.094509
19R:R:F303 6.1975464
20R:R:L307 4.17467
21R:R:M338 7.722505
22R:R:R346 5.9075428
23R:R:I355 6.4275408
24R:R:E362 7.446518
25R:R:Q392 8.17419
26R:R:Y400 8.75833628
27R:R:C401 3.56409
28R:R:N404 6.5025429
29R:R:E406 4.91429
30R:R:E410 6.2275408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D124 R:R:G125 11.11371.68NoNo022
2R:R:D124 R:R:E127 12.92663.9NoNo021
3R:R:E127 R:R:V130 14.72814.28NoNo011
4R:R:D195 R:R:Y145 12.80585.75YesNo177
5R:R:Y145 R:R:Y149 20.06333.97NoYes178
6R:R:S390 R:R:Y149 35.41876.36NoYes198
7R:R:F391 R:R:S390 31.9776.61NoNo179
8R:R:F387 R:R:F391 30.39422.14NoNo057
9R:R:F387 R:R:M144 28.69644.98NoNo056
10R:R:F141 R:R:M144 26.9876.22NoNo066
11R:R:F141 R:R:F383 23.53387.5NoNo065
12R:R:F383 R:R:Y138 20.02888.25NoNo055
13R:R:V134 R:R:Y138 18.26192.52NoNo025
14R:R:V130 R:R:V134 16.5181.6NoNo012
15R:R:K187 R:R:Y149 70.38855.97YesYes188
16R:R:V191 R:R:Y149 32.074812.62NoYes078
17R:R:S389 R:R:Y149 10.84323.82NoYes168
18R:R:F184 R:R:G393 13.34684.52YesNo089
19R:R:F184 R:R:N238 91.643214.5YesYes189
20R:R:K187 R:R:N238 90.34244.2YesYes189
21R:R:F181 R:R:V396 11.33813.93YesNo089
22R:R:F184 R:R:V396 20.59863.93YesNo089
23R:R:K168 R:R:L163 11.4364.23YesNo088
24R:R:K168 R:R:N174 21.45048.39YesNo289
25R:R:N174 R:R:R173 24.47777.23NoYes299
26R:R:H177 R:R:R173 1007.9NoYes299
27R:R:E245 R:R:H177 77.220113.54YesNo299
28R:R:E245 R:R:L180 84.52953.98YesNo099
29R:R:F184 R:R:L180 84.14963.65YesNo089
30R:R:E406 R:R:R173 45.70946.98YesYes299
31R:R:N404 R:R:R173 39.78134.82YesYes299
32R:R:L180 R:R:W241 33.69783.42NoYes099
33R:R:E245 R:R:Y400 13.968314.59YesYes298
34R:R:F181 R:R:Y400 19.08493.09YesYes088
35R:R:W241 R:R:W272 19.971214.06YesNo499
36R:R:E362 R:R:S389 14.45187.19YesNo186
37R:R:E362 R:R:Q392 10.16986.37YesYes189
38R:R:I235 R:R:K187 44.01155.82NoYes058
39R:R:M231 R:R:V191 30.38854.56YesNo067
40R:R:I194 R:R:M231 18.29642.92YesYes066
41R:R:I235 R:R:L307 42.04322.85NoYes057
42R:R:F303 R:R:L307 26.69934.87YesYes647
43R:R:F303 R:R:T296 18.73385.19YesNo045
44R:R:N291 R:R:T296 10.38851.46NoNo065
45R:R:W272 R:R:Y233 18.57274.82NoYes099
46R:R:M276 R:R:Y233 14.08355.99NoYes039
47R:R:I235 R:R:V236 12.93243.07NoYes056
48R:R:P275 R:R:V236 12.89215.3YesYes096
49R:R:N238 R:R:Y239 25.45044.65YesYes098
50R:R:L242 R:R:Y239 24.56983.52NoYes098
51R:R:C240 R:R:P275 13.78997.53NoYes069
52R:R:I355 R:R:L242 22.80294.28YesNo089
53R:R:I355 R:R:N318 14.048911.33YesNo089
54R:R:L243 R:R:N318 11.735310.98NoNo089
55R:R:V244 R:R:Y248 14.49787.57NoNo088
56R:R:T351 R:R:Y400 24.59867.49NoYes098
57R:R:L249 R:R:T351 21.91085.9NoNo099
58R:R:I325 R:R:L249 16.50074.28NoNo099
59R:R:H250 R:R:I325 13.77843.98YesNo079
60R:R:N404 R:R:R346 37.54827.23YesYes298
61R:R:R346 R:R:Y343 61.68063.09YesNo087
62R:R:L253 R:R:Y343 32.26477.03NoNo087
63R:R:E406 R:R:R346 39.18854.65YesYes298
64R:R:K344 R:R:L253 24.35687.05NoNo068
65R:R:D342 R:R:Y343 26.88924.6NoNo077
66R:R:D342 R:R:K344 24.253212.44NoNo076
67R:R:M276 R:R:V280 12.5649.13NoNo032
68R:R:L307 R:R:R308 13.76123.64YesNo076
69R:R:R308 R:R:W304 10.388511NoNo066
70R:R:F322 R:R:I355 14.00865.02NoYes098
71R:R:K344 R:R:M338 43.228823.04NoYes065
72R:R:K332 R:R:M338 16.29358.64NoYes095
73R:R:K405 R:R:T341 11.15971.5NoNo066
74R:R:K405 R:R:R346 13.92238.66NoYes068
75R:R:S350 R:R:Y400 20.79426.36NoYes098
76R:R:L399 R:R:S350 18.25614.5NoNo089
77R:R:E362 R:R:F365 12.16129.33YesNo087
78R:R:D385 R:R:F365 10.457615.52NoNo077
79R:R:F345 R:R:M338 10.87192.49NoYes075
80R:R:F322 R:R:L352 11.47632.44NoNo098
81R:R:L352 R:R:T353 11.13091.47NoNo088
82R:R:F184 R:R:Q392 14.57845.86YesYes189
83R:R:L399 R:R:T353 11.09061.47NoNo088
84R:R:H177 R:R:Y400 23.476316.33NoYes298
85R:R:C240 R:R:W241 14.34825.22NoYes069
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 4L6R
Class B1
SubFamily Peptide
Type Glucagon
SubType Glucagon
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.3
Date 2013-07-24
D.O.I. 10.1038/nature12393
Net Summary
Imin 2.98
Number of Linked Nodes 266
Number of Links 283
Number of Hubs 30
Number of Links mediated by Hubs 118
Number of Communities 9
Number of Nodes involved in Communities 46
Number of Links involved in Communities 54
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 42015
Length Of Smallest Path 3
Average Path Length 12.9502
Length of Longest Path 31
Minimum Path Strength 1.13
Average Path Strength 6.18509
Maximum Path Strength 17.74
Minimum Path Correlation 0.7
Average Path Correlation 0.954964
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 65.0606
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.1366
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47871
Sequence
>4L6R_Chain_R
MDGEEIEVQ KEVAKMYSS FQVMYTVGY SLSLGALLL ALAILGGLS 
KLHCTRNAI HANLFASFV LKASSVLVI DGLLRTLSD GAVAGCRVA 
AVFMQYGIV ANYCWLLVE GLYLHNLLG LATLPERSF FSLYLGIGW 
GAPMLFVVP WAVVKCLFE NVQCWTSND NMGFWWILR FPVFLAILI 
NFFIFVRIV QLLVAKLRA RQMHHTDYK FRLAKSTLT LIPLLGVHE 
VVFAFVTDE HAQGTLRSA KLFFDLFLS SFQGLLVAV LYCFLNKEV 
QSELRRRWH RWRLGKVLW EERN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/&β;1/&γ;22.62020-11-1810.1038/s41467-020-18945-0
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.62022-04-0610.1073/pnas.2106606118
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/&β;1/&γ;23.292021-10-2010.1073/pnas.2106606118
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/&β;1/&γ;22.982021-08-0410.7554/eLife.68719
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/&β;1/&γ;23.12022-02-2310.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/&β;1/&γ;23.242022-04-1310.1073/pnas.2116506119
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/&β;1/&γ;23.082022-04-1310.1073/pnas.2116506119
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;23.22022-03-0210.1038/s41467-022-28683-0
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.232023-10-1810.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;23.132023-10-1810.1073/pnas.2306145120
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/&β;1/&γ;22.862024-03-0610.1038/s41421-024-00649-0
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/&β;1/&γ;24.12017-05-2410.1038/nature22394
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/&β;1/&γ;23.32018-02-2110.1038/nature25773
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/&β;1/&γ;232020-01-0810.1038/s41586-019-1902-z
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/&β;1/&γ;23.32020-07-2210.1038/s41589-020-0589-7
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/&β;1/&γ;22.12020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/&β;1/&γ;22.12020-09-0910.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/&β;1/&γ;22.52020-09-0910.1016/j.molcel.2020.09.020
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/&β;1/&γ;23.12020-11-1810.1073/pnas.2014879117
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/&β;1/&γ;24.22020-08-2610.1038/s41422-020-0384-8
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/&β;1/&γ;22.52021-07-1410.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/&β;1/&γ;23.32021-08-1110.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/&β;1/&γ;22.92021-07-0710.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/&β;1/&γ;22.52021-08-1110.1038/s41467-021-24058-z
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/&β;1/&γ;22.52021-08-0410.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/&β;1/&γ;22.52021-08-0410.1016/j.celrep.2021.109374
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/&β;1/&γ;22.92021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/&β;1/&γ;23.72022-01-1210.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/&β;1/&γ;23.32022-01-1210.1038/s41467-021-27760-0
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.22022-04-1310.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/&β;1/&γ;22.92022-04-1310.1073/pnas.2116506119
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/&β;1/&γ;22.142021-10-0610.1016/j.bbrc.2021.09.016
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/&β;1/&γ;22.412022-01-0510.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/&β;1/&γ;22.512022-01-0510.1038/s41589-021-00945-w
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/&β;1/&γ;232022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/&β;1/&γ;232022-03-0210.1038/s41467-022-28683-0
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/&β;1/&γ;22.612022-06-2910.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/&β;1/&γ;23.092022-06-2910.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/&β;1/&γ;22.852023-09-0610.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/&β;1/&γ;22.572023-09-0610.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/&β;1/&γ;22.462023-11-0810.1073/pnas.2303696120
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/&β;1/&γ;22.542024-03-0610.1038/s41421-024-00649-0
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/&β;1/&γ;232020-12-1610.1038/s41422-020-00442-0
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-2410.1038/nature12393
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-2010.1038/nature17414
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-2410.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-2410.1038/nature22363
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-1710.1038/nature25153
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/&β;1/&γ;23.72020-04-0110.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon--3.92020-04-0110.1126/science.aaz5346
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/&β;1/&γ;23.42020-05-2710.1074/jbc.RA120.013793
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/&β;1/&γ;23.12020-08-1210.1126/science.aba3373
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/&β;1/&γ;23.52022-03-0210.1038/s41467-022-28683-0
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/&β;1/&γ;22.92023-04-1210.1016/j.cell.2023.02.028
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/&β;1/&γ;23.42023-09-1310.1073/pnas.2303696120
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/&β;1/&γ;22.912023-09-0610.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/&β;1/&γ;22.762023-09-1310.1073/pnas.2303696120
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-1610.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-1610.1038/s41586-023-06420-x
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/&β;1/&γ;22.712024-03-0610.1038/s41421-024-00649-0
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/&β;1/&γ;24.32020-08-1210.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/&β;1/&γ;22.32020-08-1210.1038/s41467-020-17791-4
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/&β;1/&γ;22.92020-11-0410.1016/j.bbrc.2020.08.042




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4L6R.zip



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