Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:H1 6.035400
2L:L:Q3 8.1425420
3L:L:R18 12.6675400
4R:R:F33 9.4475404
5R:R:W36 7.44616
6R:R:Y39 6.78667616
7R:R:P53 2.925403
8R:R:Y65 7.03833616
9R:R:C67 4.29419
10R:R:W68 7.37539
11R:R:T71 4.33407
12R:R:P82 7.74418
13R:R:W83 6.6275402
14R:R:Y84 9.7175415
15R:R:W87 9.0875403
16R:R:V91 3.6775406
17R:R:F97 3.2975405
18R:R:K98 8.9625438
19R:R:W106 9.05625839
20R:R:R108 6.5975431
21R:R:M123 7.2675463
22R:R:I128 3.565462
23R:R:Q142 12.635425
24R:R:Y145 8.12333627
25R:R:Y149 5.92667628
26R:R:L166 4.825407
27R:R:K168 9.7575408
28R:R:F181 4.4875408
29R:R:F184 10.1225408
30R:R:W215 15.554502
31R:R:M231 6.81406
32R:R:Y233 4.615409
33R:R:W241 11.224549
34R:R:L243 5.0154138
35R:R:Y248 8.685408
36R:R:Y267 5.3875407
37R:R:P275 3.64833609
38R:R:W282 9.424119
39R:R:W295 10.224109
40R:R:T296 3.93833605
41R:R:M301 6.465405
42R:R:W304 15.99406
43R:R:I315 4.725127
44R:R:I321 4.095408
45R:R:K344 4.575406
46R:R:T351 2.64409
47R:R:H361 7.384128
48R:R:Y400 5.26498
49R:R:C401 3.8375409
50R:R:E410 6.1025408
51L:L:?1 12.1133920
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:H1 R:R:V311 40.45256.92YesNo008
2R:R:V311 R:R:Y239 23.019115.14NoNo088
3L:L:H1 R:R:W304 91.25587.41YesYes006
4R:R:R308 R:R:W304 10025.99NoYes066
5R:R:M301 R:R:R308 99.95544.96YesNo056
6R:R:D370 R:R:M301 99.6918.32NoYes045
7R:R:D370 R:R:R378 98.757210.72NoNo544
8L:L:D9 R:R:R378 99.464411.91NoNo004
9L:L:D9 R:R:Y138 99.39925.75NoNo005
10L:L:F6 R:R:Y138 34.95616.19NoNo005
11L:L:F6 R:R:Y145 32.33668.25NoYes007
12R:R:Q142 R:R:Y145 16.698714.65YesYes257
13L:L:K10 R:R:Q142 12.20996.78NoYes205
14L:L:K10 L:L:L14 18.621311.28NoNo000
15L:L:H1 R:R:I235 56.33936.63YesNo005
16R:R:I235 R:R:M231 12.87085.83NoYes056
17L:L:E17 L:L:Y13 74.34613.47NoNo000
18L:L:Y13 R:R:Y138 74.92286.95NoNo005
19L:L:L14 R:R:Y202 18.427311.72NoNo001
20R:R:W215 R:R:Y202 18.04626.75YesNo021
21L:L:E17 L:L:R20 73.185615.12NoNo000
22L:L:R20 R:R:M123 69.13978.69NoYes603
23R:R:M123 R:R:W87 70.772110.47YesYes033
24R:R:L85 R:R:W87 46.161811.39NoYes063
25R:R:L85 R:R:P82 45.79274.93NoYes068
26R:R:P82 R:R:Y84 19.464112.52YesYes185
27R:R:W36 R:R:Y84 14.048315.43YesYes165
28L:L:E27 L:L:V23 19.63924.28NoNo000
29L:L:V23 R:R:W87 19.94823.68NoYes003
30L:L:E27 R:R:Y65 18.628113.47NoYes006
31R:R:P82 R:R:Y65 18.15449.74YesYes186
32R:R:L307 R:R:W304 13.36696.83NoYes076
33R:R:Y39 R:R:Y84 22.8566.95YesYes165
34R:R:L216 R:R:W215 15.5954.56NoYes022
35R:R:F33 R:R:L216 15.40964.87YesNo042
36R:R:F33 R:R:K37 14.87421.09YesNo043
37R:R:K37 R:R:W36 15.493711.6NoYes136
38R:R:S66 R:R:Y65 39.07926.36NoYes056
39R:R:S66 R:R:W68 42.59487.41NoYes059
40R:R:W106 R:R:W68 33.22067.5YesYes399
41R:R:C81 R:R:P82 11.13193.77NoYes098
42R:R:C121 R:R:C81 10.44367.28NoNo099
43R:R:R108 R:R:W106 11.27785YesYes319
44R:R:I235 R:R:K187 53.95847.27NoNo058
45R:R:K187 R:R:N238 53.572211.19NoNo089
46R:R:F184 R:R:N238 35.7818.12YesNo089
47R:R:F184 R:R:L180 33.75627.31YesNo089
48R:R:E245 R:R:L180 32.59927.95NoNo099
49R:R:E245 R:R:H177 32.01566.15NoNo099
50R:R:H177 R:R:Y400 19.75934.36NoYes098
51R:R:V396 R:R:Y400 15.72543.79NoYes998
52R:R:F181 R:R:V396 15.20535.24YesNo089
53R:R:H177 R:R:R173 12.42964.51NoNo099
54R:R:N174 R:R:R173 11.03418.44NoNo899
55R:R:K168 R:R:N174 10.386911.19YesNo089
56R:R:N238 R:R:S183 38.23474.47NoNo099
57R:R:S183 R:R:W241 21.4214.94NoYes499
58R:R:V244 R:R:W241 18.29513.68NoYes089
59R:R:V244 R:R:Y267 14.26813.79NoYes087
60R:R:Y248 R:R:Y267 10.148311.91YesYes087
61R:R:S183 R:R:W272 16.26273.71NoNo499
62R:R:F184 R:R:Q392 10.340610.54YesNo089
63R:R:H361 R:R:V360 11.15256.92YesNo086
64R:R:Q392 R:R:V360 10.18444.3NoNo096
65R:R:W272 R:R:Y233 17.01284.82NoYes099
66R:R:I315 R:R:Y239 15.93484.84YesNo1278
67R:R:F365 R:R:V311 17.01635.24NoNo078
68R:R:F365 R:R:I315 16.22325.02NoYes077
69R:R:I315 R:R:N318 33.79915.66YesNo079
70R:R:F319 R:R:N318 25.90461.21NoNo079
71R:R:F319 R:R:F322 24.76313.22NoNo079
72R:R:F322 R:R:V326 21.3186.55NoNo097
73R:R:L352 R:R:V326 20.162711.92NoNo087
74R:R:L352 R:R:T351 17.84191.47NoYes089
75R:R:L347 R:R:T351 14.33331.47NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H1 R:R:I235 6.63 0 Yes No 0 5 0 1
L:L:H1 R:R:W304 7.41 0 Yes Yes 0 6 0 1
L:L:H1 R:R:V311 6.92 0 Yes No 0 8 0 1
L:L:S2 R:R:K381 4.59 0 No No 0 7 0 1
L:L:S2 R:R:D385 11.78 0 No No 0 7 0 1
L:L:Q3 R:R:Y145 5.64 2 Yes Yes 0 7 0 1
L:L:Q3 R:R:Y149 10.15 2 Yes Yes 0 8 0 1
L:L:Q3 R:R:V191 11.46 2 Yes No 0 7 0 1
L:L:Q3 R:R:L386 5.32 2 Yes No 0 7 0 1
L:L:T5 R:R:D370 7.23 5 No No 0 4 0 1
L:L:T5 R:R:R378 5.17 5 No No 0 4 0 1
L:L:T5 R:R:L382 4.42 5 No No 0 5 0 1
L:L:F6 R:R:Y138 6.19 0 No No 0 5 0 1
L:L:F6 R:R:Y145 8.25 0 No Yes 0 7 0 1
L:L:F6 R:R:L386 6.09 0 No No 0 7 0 1
L:L:S8 R:R:N298 8.94 0 No No 0 6 0 1
L:L:D9 R:R:Y138 5.75 0 No No 0 5 0 1
L:L:D9 R:R:R378 11.91 0 No No 0 4 0 1
L:L:K10 R:R:Q142 6.78 2 No Yes 0 5 0 1
L:L:S11 R:R:T296 4.8 0 No Yes 0 5 0 1
L:L:Y13 R:R:A135 4 0 No No 0 3 0 1
L:L:Y13 R:R:Y138 6.95 0 No No 0 5 0 1
L:L:L14 R:R:Y202 11.72 0 No No 0 1 0 1
L:L:D15 R:R:V28 4.38 0 No No 0 3 0 1
L:L:D15 R:R:M29 5.54 0 No No 0 5 0 1
L:L:R18 R:R:M29 4.96 0 Yes No 0 5 0 1
L:L:R18 R:R:I206 12.53 0 Yes No 0 4 0 1
L:L:R18 R:R:W215 31.99 0 Yes Yes 0 2 0 1
L:L:R20 R:R:M123 8.69 6 No Yes 0 3 0 1
L:L:R20 R:R:I128 3.76 6 No Yes 0 2 0 1
L:L:F22 R:R:L32 4.87 0 No No 0 4 0 1
L:L:F22 R:R:W36 4.01 0 No Yes 0 6 0 1
L:L:V23 R:R:W87 3.68 0 No Yes 0 3 0 1
L:L:L26 R:R:W36 7.97 0 No Yes 0 6 0 1
L:L:L26 R:R:Y65 4.69 0 No Yes 0 6 0 1
L:L:E27 R:R:Y65 13.47 0 No Yes 0 6 0 1
L:L:E27 R:R:R116 17.45 0 No No 0 6 0 1
R:R:D299 R:R:Q27 5.22 0 No No 4 5 2 1
R:R:L32 R:R:P86 4.93 0 No No 4 3 1 1
R:R:K37 R:R:W36 11.6 1 No Yes 3 6 2 1
R:R:W36 R:R:Y84 15.43 1 Yes Yes 6 5 1 2
R:R:D209 R:R:W36 4.47 1 No Yes 4 6 2 1
R:R:D209 R:R:K37 8.3 1 No No 4 3 2 2
R:R:S66 R:R:Y65 6.36 0 No Yes 5 6 2 1
R:R:P82 R:R:Y65 9.74 1 Yes Yes 8 6 2 1
R:R:Y65 R:R:Y84 3.97 1 Yes Yes 6 5 1 2
R:R:A118 R:R:Y65 4 0 No Yes 5 6 2 1
R:R:P82 R:R:Y84 12.52 1 Yes Yes 8 5 2 2
R:R:L85 R:R:P82 4.93 0 No Yes 6 8 2 2
R:R:L85 R:R:W87 11.39 0 No Yes 6 3 2 1
R:R:P86 R:R:W87 10.81 0 No Yes 3 3 1 1
R:R:M123 R:R:W87 10.47 6 Yes Yes 3 3 1 1
R:R:A118 R:R:R116 5.53 0 No No 5 6 2 1
R:R:M123 R:R:Q122 4.08 6 Yes No 3 3 1 2
R:R:I128 R:R:M123 5.83 6 Yes Yes 2 3 1 1
R:R:Q131 R:R:V134 5.73 0 No No 3 2 1 2
L:L:?1 R:R:S139 11.37 2 Yes No 0 3 0 1
R:R:Q142 R:R:Y145 14.65 2 Yes Yes 5 7 1 1
R:R:D195 R:R:Q142 3.92 2 No Yes 7 5 2 1
L:L:?1 R:R:Q142 25.19 2 Yes Yes 0 5 0 1
L:L:?1 R:R:V143 7.05 2 Yes No 0 4 0 1
R:R:T146 R:R:Y145 3.75 0 No Yes 7 7 1 1
R:R:Y145 R:R:Y149 4.96 2 Yes Yes 7 8 1 1
R:R:D195 R:R:Y145 11.49 2 No Yes 7 7 2 1
R:R:L192 R:R:T146 4.42 0 No No 7 7 2 1
L:L:?1 R:R:T146 9.76 2 Yes No 0 7 0 1
R:R:G148 R:R:V147 3.68 0 No No 7 5 2 1
L:L:?1 R:R:V147 5.64 2 Yes No 0 5 0 1
R:R:G148 R:R:S390 3.71 0 No No 7 9 2 2
R:R:A188 R:R:Y149 4 0 No Yes 8 8 2 1
R:R:V191 R:R:Y149 10.09 2 No Yes 7 8 1 1
R:R:S390 R:R:Y149 3.82 0 No Yes 9 8 2 1
L:L:?1 R:R:S150 7.1 2 Yes No 0 7 0 1
L:L:?1 R:R:L151 5.24 2 Yes No 0 5 0 1
R:R:I235 R:R:K187 7.27 0 No No 5 8 1 2
R:R:I194 R:R:M231 7.29 0 No Yes 6 6 2 2
R:R:G196 R:R:R199 4.5 0 No No 3 4 2 1
R:R:L198 R:R:T296 5.9 0 No Yes 6 5 2 1
L:L:?1 R:R:R199 22.99 2 Yes No 0 4 0 1
R:R:R201 R:R:W215 28.99 0 No Yes 4 2 2 1
R:R:W215 R:R:Y202 6.75 0 Yes No 2 1 1 1
R:R:Q204 R:R:W215 5.48 0 No Yes 4 2 2 1
R:R:L216 R:R:W215 4.56 0 No Yes 2 2 2 1
R:R:I235 R:R:M231 5.83 0 No Yes 5 6 1 2
R:R:V311 R:R:Y239 15.14 0 No No 8 8 1 2
R:R:H361 R:R:Y239 9.8 12 Yes No 8 8 2 2
R:R:C294 R:R:T296 5.07 0 No Yes 9 5 2 1
R:R:N298 R:R:W304 23.73 0 No Yes 6 6 1 1
R:R:M301 R:R:R308 4.96 0 Yes No 5 6 2 2
R:R:D370 R:R:M301 8.32 5 No Yes 4 5 1 2
R:R:L307 R:R:W304 6.83 11 No Yes 7 6 2 1
R:R:R308 R:R:W304 25.99 0 No Yes 6 6 2 1
R:R:F365 R:R:V311 5.24 0 No No 7 8 2 1
R:R:D385 R:R:H361 8.82 0 No Yes 7 8 1 2
R:R:K381 R:R:V364 6.07 0 No No 7 6 1 2
R:R:D370 R:R:R378 10.72 5 No No 4 4 1 1
R:R:D385 R:R:S389 5.89 0 No No 7 6 1 2
R:R:Q293 R:R:Y202 3.38 0 No No 4 1 2 1
L:L:T7 R:R:T296 3.14 0 No Yes 0 5 0 1
R:R:I206 R:R:S211 3.1 0 No No 4 4 1 2
R:R:I194 R:R:T296 3.04 0 No Yes 6 5 2 1
R:R:I128 R:R:K132 2.91 6 Yes No 2 2 1 2
L:L:E12 R:R:S297 2.87 0 No No 0 4 0 1
R:R:Q131 R:R:V130 2.87 0 No No 3 1 1 2
L:L:E12 R:R:Q27 2.55 0 No No 0 5 0 1
L:L:E17 R:R:Q131 2.55 0 No No 0 3 0 1
R:R:S152 R:R:Y149 2.54 0 No Yes 9 8 2 1
L:L:A19 R:R:P86 1.87 0 No No 0 3 0 1
R:R:G125 R:R:I128 1.76 0 No Yes 2 2 2 1
R:R:A228 R:R:T296 1.68 0 No Yes 5 5 2 1
R:R:R199 R:R:S203 1.32 0 No No 4 4 1 2
R:R:K64 R:R:W36 1.16 0 No Yes 4 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JIT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.68
Number of Linked Nodes 396
Number of Links 427
Number of Hubs 51
Number of Links mediated by Hubs 204
Number of Communities 13
Number of Nodes involved in Communities 59
Number of Links involved in Communities 69
Path Summary
Number Of Nodes in MetaPath 76
Number Of Links MetaPath 75
Number of Shortest Paths 103684
Length Of Smallest Path 3
Average Path Length 19.5669
Length of Longest Path 40
Minimum Path Strength 1.07
Average Path Strength 8.19441
Maximum Path Strength 30.49
Minimum Path Correlation 0.7
Average Path Correlation 0.960613
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 58.3548
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 34.8159
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • cell projection membrane   • synapse   • cell junction   • cell body   • G-protein beta-subunit binding   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • peptide hormone binding   • hormone binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • circulatory system process   • regulation of blood pressure   • blood circulation   • regulation of biosynthetic process   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • carbohydrate metabolic process   • energy derivation by oxidation of organic compounds   • glycogen metabolic process   • primary metabolic process   • regulation of generation of precursor metabolites and energy   • generation of precursor metabolites and energy   • regulation of polysaccharide metabolic process   • regulation of primary metabolic process   • glucan metabolic process   • polysaccharide metabolic process   • energy reserve metabolic process   • regulation of glycogen metabolic process   • regulation of carbohydrate metabolic process   • cellular response to nutrient levels   • response to nutrient levels   • response to starvation   • cellular response to starvation   • cell surface receptor signaling pathway   • response to nutrient   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like   • FnI-like domain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like   • FnI-like domain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeD6M
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeD6M
NameN-hexadecanoyl-L-glutamic acid
Synonyms
Identifier
FormulaC21 H39 N O5
Molecular Weight385.538
SMILES
PubChem161955
Formal Charge0
Total Atoms66
Total Chiral Atoms1
Total Bonds65
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47871
Sequence
>8JIT_nogp_Chain_R
QVMDFLFEK WKLYGDQCH HNLSLLPPP TELVCNRTF DKYSCWPDT 
PANTTANIS CPWYLPWHH KVQHRFVFK RCGPDGQWV RGPRGQPWR 
DASQCQMDG EEIEVQKEV AKMYSSFQV MYTVGYSLS LGALLLALA 
ILGGLSKLH CTRNAIHAN LFASFVLKA SSVLVIDGL LRTRYSQKI 
GDDLSVSTW LSDGAVAGC RVAAVFMQY GIVANYCWL LVEGLYLHN 
LLGLATLPE RSFFSLYLG IGWGAPMLF VVPWAVVKC LFENVQCWT 
SNDNMGFWW ILRFPVFLA ILINFFIFV RIVQLLVAK LRARQMHHT 
DYKFRLAKS TLTLIPLLG VHEVVFAFV TDEHAQGTL RSAKLFFDL 
FLSSFQGLL VAVLYCFLN KEVQSELRR RWHRWRLG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiens-Peptide2.712024-03-06doi.org/10.1038/s41421-024-00649-0
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-24doi.org/10.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-24doi.org/10.1038/nature22363
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-20doi.org/10.1038/nature17414
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatideLSN3556672chim(NtGi1-Gs)/β1/γ23.082022-04-13doi.org/10.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatideLSN35566723.082022-04-13doi.org/10.1073/pnas.2116506119
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-18doi.org/10.1038/s41467-020-18945-0
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-06doi.org/10.1038/s41421-024-00649-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-02doi.org/10.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-02doi.org/10.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-13doi.org/10.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-13doi.org/10.1073/pnas.2116506119
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-18doi.org/10.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-18doi.org/10.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-18doi.org/10.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-18doi.org/10.1073/pnas.2306145120
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-04doi.org/10.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-04doi.org/10.7554/eLife.68719
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ23.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-16doi.org/10.1038/s41422-020-00442-0
7D68 (No Gprot) B1PeptideGlucagonGLP-2Homo sapiensGLP-2-32020-12-16doi.org/10.1038/s41422-020-00442-0
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ22.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8FU6 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-2.92023-04-12doi.org/10.1016/j.cell.2023.02.028
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-24doi.org/10.1038/nature12393
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-17doi.org/10.1038/nature25153
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-02doi.org/10.1038/s41467-022-28683-0
7V35 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-3.52022-03-02doi.org/10.1038/s41467-022-28683-0
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-16doi.org/10.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-16doi.org/10.1038/s41586-023-06420-x
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-06doi.org/10.1073/pnas.2303696120
8JIT (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensMEDI0382-2.912023-09-06doi.org/10.1073/pnas.2303696120
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-13doi.org/10.1073/pnas.2303696120
8JIQ (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-15-3.42023-09-13doi.org/10.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-13doi.org/10.1073/pnas.2303696120
8JIU (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensSAR425899-2.762023-09-13doi.org/10.1073/pnas.2303696120
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-27doi.org/10.1074/jbc.RA120.013793
6WHC (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-3.42020-05-27doi.org/10.1074/jbc.RA120.013793
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-01doi.org/10.1126/science.aaz5346
6LMK (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.72020-04-01doi.org/10.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-01doi.org/10.1126/science.aaz5346
6LML (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.92020-04-01doi.org/10.1126/science.aaz5346
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ23.12020-08-12doi.org/10.1126/science.aba3373
6WPW (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-3.12020-08-12doi.org/10.1126/science.aba3373
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-2.842024-09-18doi.org/10.1038/s41421-024-00700-0
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-12doi.org/10.1038/s41467-020-17791-4




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