psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M144	R:R:S140	6.13	Yes	No	4	6	4
2	R:R:F383	R:R:S140	5.28	Yes	No	4	5	4
3	R:R:F141	R:R:F383	25.72	No	Yes	0	6	5
4	R:R:Q142	R:R:Y145	2.25	No	Yes	4	5	7
5	R:R:D195	R:R:Q142	5.22	No	No	4	7	5
6	R:R:Q142	R:R:R199	3.5	No	No	4	5	4
7	R:R:F383	R:R:M144	3.73	Yes	Yes	4	5	6
8	R:R:L386	R:R:M144	2.83	No	Yes	4	7	6
9	R:R:F387	R:R:M144	3.73	No	Yes	0	5	6
10	R:R:Y145	R:R:Y149	1.99	Yes	Yes	4	7	8
11	R:R:V191	R:R:Y145	3.79	No	Yes	4	7	7
12	R:R:L386	R:R:Y145	10.55	No	Yes	4	7	7
13	R:R:G148	R:R:V147	1.84	No	No	0	7	5
14	R:R:G148	R:R:S390	3.71	No	No	0	7	9
15	R:R:K187	R:R:Y149	2.39	No	Yes	0	8	8
16	R:R:A188	R:R:Y149	2.67	No	Yes	0	8	8
17	R:R:V191	R:R:Y149	16.4	No	Yes	4	7	8
18	R:R:L192	R:R:Y149	2.34	No	Yes	0	7	8
19	R:R:S390	R:R:Y149	5.09	No	Yes	0	9	8
20	R:R:L151	R:R:L394	2.77	No	No	0	5	5
21	R:R:A188	R:R:L153	3.15	No	Yes	0	8	6
22	R:R:F181	R:R:L156	4.87	Yes	Yes	0	8	8
23	R:R:F184	R:R:L156	2.44	Yes	Yes	0	8	8
24	R:R:L156	R:R:V185	4.47	Yes	No	0	8	8
25	R:R:A397	R:R:L156	3.15	No	Yes	0	8	8
26	R:R:I162	R:R:L158	2.85	No	No	0	8	5
27	R:R:F402	R:R:L158	2.44	No	No	0	9	5
28	R:R:A159	R:R:F181	2.77	No	Yes	0	9	8
29	R:R:A159	R:R:C401	3.61	No	No	0	9	9
30	R:R:F181	R:R:L160	3.65	Yes	No	0	8	6
31	R:R:L163	R:R:N174	5.49	No	Yes	0	8	9
32	R:R:F181	R:R:L163	2.44	Yes	No	0	8	8
33	R:R:G164	R:R:G165	2.11	No	No	0	3	3
34	R:R:G165	R:R:L169	3.42	No	No	5	3	9
35	H:H:?701	R:R:G165	5.74	Yes	No	5	0	3
36	R:R:K168	R:R:L166	4.23	Yes	No	1	8	7
37	R:R:E410	R:R:L166	5.3	Yes	No	1	8	7
38	R:R:L166	R:R:R414	3.64	No	No	1	7	5
39	R:R:E410	R:R:S167	2.87	Yes	No	0	8	8
40	R:R:K168	R:R:N174	6.99	Yes	Yes	1	8	9
41	R:R:K168	R:R:V407	4.55	Yes	No	0	8	9
42	R:R:E410	R:R:K168	2.7	Yes	Yes	1	8	8
43	H:H:?701	R:R:L169	9.28	Yes	No	5	0	9
44	R:R:H170	V:V:R188	4.51	No	Yes	0	7	8
45	R:R:C171	R:R:R173	5.57	No	Yes	1	7	9
46	R:R:C171	R:R:N174	7.87	No	Yes	1	7	9
47	R:R:T172	R:R:Y248	4.99	No	No	0	7	8
48	R:R:N174	R:R:R173	9.64	Yes	Yes	1	9	9
49	R:R:R173	R:R:Y248	3.09	Yes	No	0	9	8
50	R:R:R173	R:R:Y343	2.06	Yes	No	0	9	7
51	R:R:L347	R:R:R173	7.29	No	Yes	1	9	9
52	R:R:A175	R:R:F264	4.16	No	No	0	6	6
53	R:R:I176	R:R:W241	9.4	No	Yes	1	9	9
54	R:R:I176	R:R:V244	3.07	No	Yes	1	9	8
55	R:R:F264	R:R:I176	3.77	No	No	0	6	9
56	R:R:F181	R:R:H177	2.26	Yes	Yes	1	8	9
57	R:R:H177	R:R:R346	2.26	Yes	Yes	1	9	8
58	R:R:H177	R:R:L347	2.57	Yes	No	1	9	9
59	R:R:H177	R:R:Y400	22.87	Yes	Yes	1	9	8
60	R:R:N179	R:R:W241	11.3	No	Yes	0	8	9
61	R:R:F184	R:R:L180	4.87	Yes	Yes	1	8	9
62	R:R:L180	R:R:W241	6.83	Yes	Yes	1	9	9
63	R:R:L180	R:R:V396	2.98	Yes	Yes	1	9	9
64	R:R:L180	R:R:Y400	2.34	Yes	Yes	1	9	8
65	R:R:F181	R:R:V396	2.62	Yes	Yes	1	8	9
66	R:R:F181	R:R:Y400	5.16	Yes	Yes	1	8	8
67	R:R:F184	R:R:N238	18.12	Yes	No	0	8	9
68	R:R:F184	R:R:Q392	3.51	Yes	Yes	1	8	9
69	R:R:F184	R:R:G393	4.52	Yes	No	0	8	9
70	R:R:F184	R:R:V396	9.18	Yes	Yes	1	8	9
71	R:R:F230	R:R:L186	2.44	Yes	No	0	4	7
72	R:R:I235	R:R:K187	5.82	No	No	0	5	8
73	R:R:F230	R:R:S190	3.96	Yes	No	0	4	5
74	R:R:M231	R:R:S190	4.6	No	No	0	6	5
75	R:R:M231	R:R:V191	3.04	No	No	0	6	7
76	R:R:A227	R:R:I194	3.25	No	No	0	6	6
77	R:R:I194	R:R:M231	4.37	No	No	0	6	6
78	R:R:D195	R:R:G196	6.71	No	No	0	7	3
79	R:R:D195	R:R:R199	4.76	No	No	4	7	4
80	R:R:L198	R:R:R201	2.43	No	No	0	6	4
81	R:R:A220	R:R:G223	1.95	No	No	0	6	3
82	R:R:C294	R:R:V221	3.42	No	No	0	9	4
83	R:R:C224	R:R:C294	5.46	No	No	0	9	9
84	R:R:R225	R:R:W295	2	No	Yes	0	8	9
85	R:R:A228	R:R:W295	5.19	No	Yes	0	5	9
86	R:R:F230	R:R:V229	5.24	Yes	No	0	4	6
87	R:R:Q232	R:R:W282	13.14	No	Yes	11	7	9
88	R:R:L307	R:R:Q232	5.32	No	No	11	7	7
89	R:R:A237	R:R:Y233	4	No	Yes	0	7	9
90	R:R:W272	R:R:Y233	3.86	Yes	Yes	0	9	9
91	R:R:M276	R:R:Y233	2.39	No	Yes	0	3	9
92	R:R:V279	R:R:Y233	10.09	No	Yes	0	6	9
93	R:R:A237	R:R:G234	1.95	No	No	0	7	5
94	R:R:I235	R:R:Y239	3.63	No	Yes	0	5	8
95	R:R:P275	R:R:V236	1.77	Yes	No	0	9	6
96	R:R:P310	R:R:V236	3.53	No	No	0	9	6
97	R:R:V236	R:R:V311	3.21	No	No	0	6	8
98	R:R:V311	R:R:Y239	7.57	No	Yes	0	8	8
99	R:R:I315	R:R:Y239	4.84	Yes	Yes	17	7	8
100	R:R:E362	R:R:Y239	14.59	No	Yes	17	8	8
101	R:R:C240	R:R:G271	1.96	No	Yes	1	6	9
102	R:R:C240	R:R:P275	9.41	No	Yes	1	6	9
103	R:R:V244	R:R:W241	17.16	Yes	Yes	1	8	9
104	R:R:G271	R:R:W241	5.63	Yes	Yes	1	9	9
105	R:R:W241	R:R:W272	2.81	Yes	Yes	0	9	9
106	R:R:L242	R:R:N318	4.12	No	Yes	12	9	9
107	R:R:I355	R:R:L242	2.85	Yes	No	12	8	9
108	R:R:L242	R:R:L358	2.77	No	No	0	9	9
109	R:R:L243	R:R:L247	2.77	No	No	0	8	7
110	R:R:I317	R:R:L243	5.71	No	No	0	6	8
111	R:R:L243	R:R:N318	10.98	No	Yes	0	8	9
112	R:R:V244	R:R:Y267	7.57	Yes	Yes	1	8	7
113	R:R:I270	R:R:V244	3.07	No	Yes	0	7	8
114	R:R:G271	R:R:V244	1.84	Yes	Yes	1	9	8
115	R:R:E245	R:R:T351	9.88	No	No	0	9	9
116	R:R:E245	R:R:Y400	10.1	No	Yes	0	9	8
117	R:R:L247	R:R:Y267	3.52	No	Yes	0	7	7
118	R:R:I321	R:R:L247	2.85	No	No	0	8	7
119	R:R:Y248	R:R:Y267	3.97	No	Yes	0	8	7
120	R:R:L249	R:R:L253	2.77	Yes	Yes	0	9	8
121	R:R:I325	R:R:L249	5.71	No	Yes	0	9	9
122	R:R:A348	R:R:L249	3.15	No	Yes	0	7	9
123	R:R:L249	R:R:T351	4.42	Yes	No	0	9	9
124	R:R:H250	R:R:N251	2.55	No	No	0	7	7
125	R:R:H250	R:R:R324	2.26	No	No	0	7	8
126	R:R:F263	R:R:N251	8.46	Yes	No	1	5	7
127	R:R:N251	R:R:Y267	6.98	No	Yes	1	7	7
128	R:R:L252	R:R:Y343	11.72	No	No	0	8	7
129	R:R:L253	R:R:L328	4.15	Yes	No	0	8	8
130	R:R:L253	R:R:L329	2.77	Yes	No	8	8	9
131	R:R:K344	R:R:L253	5.64	Yes	Yes	8	6	8
132	R:R:E260	R:R:R261	8.14	No	Yes	1	6	5
133	R:R:E260	R:R:F263	3.5	No	Yes	1	6	5
134	R:R:F263	R:R:R261	2.14	Yes	Yes	1	5	5
135	R:R:R261	V:V:S193	5.27	Yes	No	0	5	9
136	R:R:F263	R:R:Y267	3.09	Yes	Yes	1	5	7
137	R:R:L266	R:R:Y267	3.52	No	Yes	0	3	7
138	R:R:L268	R:R:W272	2.28	No	Yes	0	5	9
139	R:R:G269	R:R:G273	2.11	No	No	0	4	6
140	R:R:G271	R:R:P275	2.03	Yes	Yes	1	9	9
141	R:R:G273	R:R:P275	2.03	No	Yes	0	6	9
142	R:R:A274	R:R:P275	1.87	No	Yes	0	4	9
143	R:R:A274	R:R:F278	2.77	No	No	0	4	5
144	R:R:L277	R:R:M276	2.83	No	No	0	4	3
145	R:R:F278	R:R:L277	2.44	No	No	0	5	4
146	R:R:L307	R:R:V279	5.96	No	No	0	7	6
147	R:R:P281	R:R:V280	5.3	No	No	0	4	2
148	R:R:A283	R:R:W282	2.59	No	Yes	0	5	9
149	R:R:W282	R:R:W295	9.37	Yes	Yes	0	9	9
150	R:R:F303	R:R:W282	20.04	Yes	Yes	11	4	9
151	R:R:I306	R:R:W282	5.87	No	Yes	11	8	9
152	R:R:L307	R:R:W282	9.11	No	Yes	11	7	9
153	R:R:F303	R:R:V285	6.55	Yes	No	0	4	5
154	R:R:K286	R:R:W295	15.08	No	Yes	0	8	9
155	R:R:D299	R:R:E290	3.9	No	No	0	4	6
156	R:R:D299	R:R:V292	4.38	No	No	0	4	4
157	R:R:C294	R:R:W295	2.61	No	Yes	0	9	9
158	R:R:M301	R:R:N300	2.8	No	No	0	5	5
159	R:R:M301	R:R:W304	9.31	No	Yes	18	5	6
160	R:R:M301	R:R:W305	4.65	No	No	18	5	7
161	R:R:F303	R:R:I306	7.54	Yes	No	11	4	8
162	R:R:W304	R:R:W305	8.43	Yes	No	18	6	7
163	R:R:R308	R:R:W304	4	Yes	Yes	0	6	6
164	R:R:R308	R:R:V311	3.92	Yes	No	0	6	8
165	R:R:F312	R:R:R308	3.21	No	Yes	0	5	6
166	R:R:E362	R:R:R308	8.14	No	Yes	0	8	6
167	R:R:F309	R:R:P310	4.33	No	No	0	4	9
168	R:R:F312	R:R:V363	5.24	No	No	0	5	6
169	R:R:A366	R:R:F312	2.77	No	No	0	7	5
170	R:R:I317	R:R:L313	5.71	No	No	0	6	3
171	R:R:G359	R:R:I315	5.29	No	Yes	0	9	7
172	R:R:E362	R:R:I315	2.73	No	Yes	17	8	7
173	R:R:I315	R:R:V363	3.07	Yes	No	0	7	6
174	R:R:I355	R:R:N318	5.66	Yes	Yes	12	8	9
175	R:R:F322	R:R:V326	2.62	No	No	0	9	7
176	R:R:F322	R:R:I355	2.51	No	Yes	12	9	8
177	R:R:F322	R:R:P356	8.67	No	No	12	9	9
178	R:R:Q327	R:R:V323	4.3	No	No	0	8	5
179	R:R:I325	R:R:L329	2.85	No	No	0	9	9
180	R:R:K332	R:R:L328	8.46	No	No	0	9	8
181	R:R:K344	R:R:L329	7.05	Yes	No	8	6	9
182	R:R:K332	R:R:Q337	6.78	No	No	0	9	7
183	R:R:H339	R:R:L333	3.86	No	No	0	4	7
184	R:R:K344	R:R:L333	5.64	Yes	No	8	6	7
185	R:R:F345	R:R:L333	2.44	No	No	8	7	7
186	R:R:M338	R:R:Q337	2.72	No	No	0	5	7
187	R:R:M338	R:R:T341	4.52	No	No	8	5	6
188	R:R:K344	R:R:M338	15.84	Yes	No	8	6	5
189	R:R:H339	R:R:H340	5.97	No	No	0	4	5
190	R:R:K344	R:R:T341	4.5	Yes	No	8	6	6
191	R:R:F345	R:R:K344	8.69	No	Yes	8	7	6
192	R:R:L347	R:R:R346	3.64	No	Yes	1	9	8
193	R:R:R346	R:R:S350	5.27	Yes	No	0	8	9
194	R:R:L403	R:R:R346	2.43	No	Yes	0	5	8
195	R:R:N404	R:R:R346	15.67	No	Yes	0	9	8
196	R:R:K349	R:R:L352	5.64	No	No	0	9	8
197	R:R:K349	R:R:T353	4.5	No	No	0	9	8
198	R:R:L399	R:R:S350	4.5	No	No	0	8	9
199	R:R:S350	R:R:Y400	5.09	No	Yes	0	9	8
200	R:R:L354	R:R:T353	4.42	Yes	No	0	9	8
201	R:R:L354	R:R:L395	2.77	Yes	No	0	9	6
202	R:R:L354	R:R:V396	4.47	Yes	Yes	0	9	9
203	R:R:L354	R:R:Y400	5.86	Yes	Yes	0	9	8
204	R:R:I355	R:R:P356	5.08	Yes	No	12	8	9
205	R:R:L357	R:R:L358	2.77	No	No	0	9	9
206	R:R:L358	R:R:Q392	10.65	No	Yes	0	9	9
207	R:R:D385	R:R:H361	15.13	No	Yes	1	7	8
208	R:R:H361	R:R:L388	6.43	Yes	No	1	8	6
209	R:R:H361	R:R:S389	5.58	Yes	No	1	8	6
210	R:R:H361	R:R:Q392	3.71	Yes	Yes	1	8	9
211	R:R:F365	R:R:K381	2.48	No	No	0	7	7
212	R:R:D385	R:R:F365	28.66	No	No	0	7	7
213	R:R:A380	R:R:F384	4.16	No	No	0	4	4
214	R:R:K381	R:R:L382	5.64	No	No	0	7	5
215	R:R:F383	R:R:L386	6.09	Yes	No	4	5	7
216	R:R:F384	R:R:F387	2.14	No	No	0	4	5
217	R:R:D385	R:R:L388	5.43	No	No	1	7	6
218	R:R:F387	R:R:F391	4.29	No	No	0	5	7
219	R:R:Q392	R:R:S389	5.78	Yes	No	1	9	6
220	R:R:F391	R:R:L394	2.44	No	No	0	7	5
221	R:R:L395	R:R:L399	2.77	No	No	0	6	8
222	R:R:F402	R:R:V398	7.87	No	No	0	9	6
223	R:R:E406	R:R:N404	3.94	No	No	0	9	9
224	R:R:E406	R:R:K405	2.7	No	No	0	9	6
225	R:R:K405	R:R:Q408	4.07	No	No	0	6	7
226	R:R:L411	R:R:V407	2.98	No	No	0	5	9
227	R:R:Q408	R:R:R412	3.5	No	No	0	7	5
228	R:R:R412	R:R:S409	3.95	No	No	0	5	4
229	R:R:E410	R:R:R413	4.65	Yes	No	0	8	7
230	R:R:E410	R:R:R414	6.98	Yes	No	1	8	5
231	R:R:H416	R:R:R412	2.26	No	No	0	3	5
232	R:R:W415	R:R:W418	6.56	No	No	19	5	3
233	R:R:R419	R:R:W415	9	No	No	19	5	5
234	R:R:H416	V:V:N245	20.41	No	No	0	3	8
235	R:R:R419	R:R:W418	3	No	No	19	5	3
236	R:R:K422	R:R:W418	3.48	No	No	0	5	3
237	R:R:L420	R:R:L424	2.77	No	No	0	4	4
238	R:R:L420	V:V:A247	6.3	No	No	0	4	8
239	R:R:L420	V:V:Y249	3.52	No	No	0	4	7
240	R:R:G421	R:R:W425	2.81	No	Yes	0	4	2
241	R:R:E426	R:R:V423	5.7	No	No	0	4	3
242	R:R:L424	R:R:W425	7.97	No	Yes	0	4	2
243	R:R:L424	V:V:L243	2.77	No	Yes	0	4	7
244	R:R:W425	V:V:L129	2.28	Yes	Yes	2	2	8
245	R:R:W425	V:V:I140	4.7	Yes	No	2	2	9
246	R:R:W425	V:V:R285	11	Yes	No	2	2	7
247	R:R:W425	V:V:G286	2.81	Yes	No	2	2	9
248	V:V:V8	V:V:Y21	2.52	No	Yes	3	7	8
249	V:V:G23	V:V:V8	1.84	No	No	0	8	7
250	V:V:L104	V:V:V8	7.45	No	No	3	9	7
251	V:V:F9	V:V:R25	9.62	No	Yes	0	6	9
252	V:V:K10	V:V:Y21	8.36	No	Yes	0	9	8
253	V:V:K11	V:V:R165	6.19	No	No	0	9	5
254	V:V:K11	V:V:L166	9.87	No	Yes	0	9	8
255	V:V:P14	V:V:S13	5.34	No	No	0	6	8
256	V:V:N15	V:V:S13	7.45	Yes	No	0	8	8
257	V:V:L18	V:V:S13	3	No	No	0	6	8
258	V:V:P14	V:V:R161	4.32	No	No	0	6	7
259	V:V:K17	V:V:N15	5.6	No	Yes	9	5	8
260	V:V:N15	V:V:Y47	2.33	Yes	No	9	8	5
261	V:V:N15	V:V:N162	6.81	Yes	No	9	8	8
262	V:V:D44	V:V:K17	4.15	No	No	0	8	5
263	V:V:K17	V:V:Y47	15.53	No	No	9	5	5
264	V:V:L18	V:V:V43	2.98	No	No	0	6	6
265	V:V:T19	V:V:Y21	2.5	No	Yes	0	7	8
266	V:V:L22	V:V:V20	2.98	No	Yes	10	8	6
267	V:V:V20	V:V:V41	3.21	Yes	No	0	6	5
268	V:V:F115	V:V:V20	2.62	Yes	Yes	10	9	6
269	V:V:L166	V:V:V20	2.98	Yes	Yes	10	8	6
270	V:V:V40	V:V:Y21	3.79	Yes	Yes	3	8	8
271	V:V:L104	V:V:Y21	4.69	No	Yes	3	9	8
272	V:V:L108	V:V:Y21	10.55	Yes	Yes	0	8	8
273	V:V:L166	V:V:L22	6.92	Yes	No	10	8	8
274	V:V:G23	V:V:L100	3.42	No	No	0	8	5
275	V:V:D26	V:V:K24	8.3	Yes	No	0	9	7
276	V:V:E35	V:V:K24	8.1	No	No	0	6	7
277	V:V:L166	V:V:R25	3.64	Yes	Yes	0	8	9
278	V:V:R25	V:V:V167	3.92	Yes	No	0	9	5
279	V:V:L293	V:V:R25	4.86	Yes	Yes	0	8	9
280	V:V:D26	V:V:V171	2.92	Yes	No	0	9	6
281	V:V:D26	V:V:P360	11.27	Yes	Yes	0	9	1
282	V:V:D26	V:V:H362	6.3	Yes	No	0	9	1
283	V:V:E35	V:V:F27	5.83	No	No	0	6	8
284	V:V:F27	V:V:V37	15.73	No	No	0	8	8
285	V:V:F27	V:V:I168	6.28	No	No	0	8	8
286	V:V:H30	V:V:V28	8.3	No	No	0	6	8
287	V:V:V28	V:V:Y173	2.52	No	Yes	0	8	4
288	V:V:D29	V:V:V34	5.84	No	No	0	9	7
289	V:V:D29	V:V:K170	17.97	No	No	0	9	9
290	V:V:D29	V:V:Q172	6.53	No	Yes	0	9	9
291	V:V:H30	V:V:L33	6.43	No	No	0	6	3
292	V:V:I31	V:V:L305	4.28	No	No	0	5	5
293	V:V:I31	V:V:R307	2.51	No	No	0	5	4
294	V:V:D32	V:V:L33	2.71	No	No	0	4	3
295	V:V:I119	V:V:V34	7.68	Yes	No	0	5	7
296	V:V:P121	V:V:V34	1.77	No	No	0	4	7
297	V:V:E35	V:V:P36	3.14	No	No	0	6	5
298	V:V:F117	V:V:V37	6.55	Yes	No	0	8	8
299	V:V:I119	V:V:V37	3.07	Yes	No	0	5	8
300	V:V:D38	V:V:T98	4.34	No	No	3	7	8
301	V:V:D38	V:V:L100	5.43	No	No	0	7	5
302	V:V:D38	V:V:Q101	3.92	No	Yes	3	7	9
303	V:V:G39	V:V:Q101	3.29	No	Yes	0	8	9
304	V:V:F115	V:V:G39	4.52	Yes	No	0	9	8
305	V:V:Q101	V:V:V40	2.87	Yes	Yes	3	9	8
306	V:V:L104	V:V:V40	5.96	No	Yes	3	9	8
307	V:V:I105	V:V:V40	3.07	No	Yes	3	4	8
308	V:V:A112	V:V:V40	3.39	No	Yes	0	8	8
309	V:V:P114	V:V:V40	1.77	Yes	Yes	3	8	8
310	V:V:S86	V:V:V41	3.23	No	No	0	6	5
311	V:V:L108	V:V:L42	5.54	Yes	No	0	8	5
312	V:V:L48	V:V:V43	11.92	No	No	0	4	6
313	V:V:D44	V:V:P45	3.22	No	No	0	8	4
314	V:V:H111	V:V:P45	9.15	No	No	0	6	4
315	V:V:V150	V:V:Y47	3.79	No	No	0	5	5
316	V:V:L48	V:V:P88	3.28	No	Yes	13	4	9
317	V:V:L48	V:V:Y113	3.52	No	No	13	4	3
318	V:V:E50	V:V:V150	2.85	No	No	0	4	5
319	V:V:F87	V:V:R51	4.28	Yes	No	0	4	6
320	V:V:R52	V:V:Y54	14.4	No	Yes	0	6	4
321	V:V:F87	V:V:R52	4.28	Yes	No	0	4	6
322	V:V:S86	V:V:V53	3.23	No	No	0	6	7
323	V:V:Q85	V:V:Y54	3.38	No	Yes	0	9	4
324	V:V:F149	V:V:Y54	4.13	Yes	Yes	0	5	4
325	V:V:L154	V:V:Y54	9.38	Yes	Yes	0	3	4
326	V:V:F115	V:V:V55	11.8	Yes	No	10	9	8
327	V:V:F117	V:V:V55	3.93	Yes	No	10	8	8
328	V:V:A148	V:V:V55	5.09	No	No	0	6	8
329	V:V:N83	V:V:T56	2.92	No	No	0	5	7
330	V:V:K147	V:V:T56	4.5	No	No	16	7	7
331	V:V:F149	V:V:T56	5.19	Yes	No	16	5	7
332	V:V:F80	V:V:L57	2.44	Yes	Yes	0	4	7
333	V:V:F117	V:V:L57	12.18	Yes	Yes	0	8	7
334	V:V:I119	V:V:L57	2.85	Yes	Yes	0	5	7
335	V:V:L57	V:V:V146	4.47	Yes	No	0	7	6
336	V:V:D78	V:V:T58	5.78	Yes	No	14	8	7
337	V:V:T58	V:V:V81	3.17	No	No	14	7	4
338	V:V:A59	V:V:L79	3.15	No	No	0	8	8
339	V:V:A59	V:V:Y144	9.34	No	Yes	0	8	7
340	V:V:A60	V:V:R76	5.53	No	No	14	8	8
341	V:V:A60	V:V:D78	3.09	No	Yes	14	8	8
342	V:V:F61	V:V:V142	3.93	Yes	Yes	2	9	9
343	V:V:F61	V:V:L243	6.09	Yes	Yes	0	9	7
344	V:V:F61	V:V:G316	3.01	Yes	No	2	9	8
345	V:V:F61	V:V:I317	5.02	Yes	Yes	2	9	8
346	V:V:R62	V:V:R76	9.6	No	No	0	8	8
347	V:V:D143	V:V:R62	9.53	No	No	0	7	8
348	V:V:E145	V:V:R62	3.49	No	No	0	7	8
349	V:V:F75	V:V:Y63	6.19	No	No	0	9	9
350	V:V:L243	V:V:Y63	7.03	Yes	No	0	7	9
351	V:V:D78	V:V:R76	7.15	Yes	No	14	8	8
352	V:V:K77	V:V:L315	9.87	No	No	0	9	5
353	V:V:D78	V:V:V81	4.38	Yes	No	14	8	4
354	V:V:A82	V:V:F80	4.16	No	Yes	0	4	4
355	V:V:F80	V:V:P120	11.56	Yes	Yes	2	4	7
356	V:V:F80	V:V:L123	2.44	Yes	Yes	2	4	6
357	V:V:A82	V:V:F117	2.77	No	Yes	0	4	8
358	V:V:L154	V:V:N83	4.12	Yes	No	0	3	5
359	V:V:F117	V:V:V84	6.55	Yes	No	0	8	3
360	V:V:S86	V:V:Y113	2.54	No	No	0	6	3
361	V:V:F87	V:V:P88	8.67	Yes	Yes	13	4	9
362	V:V:F87	V:V:P89	24.56	Yes	No	13	4	3
363	V:V:P88	V:V:P89	5.84	Yes	No	13	9	3
364	V:V:P88	V:V:Y113	12.52	Yes	No	13	9	3
365	V:V:A90	V:V:P91	1.87	No	No	0	1	3
366	V:V:K94	V:V:P96	6.69	No	No	0	3	3
367	V:V:K95	V:V:L97	4.23	Yes	No	3	3	4
368	V:V:K95	V:V:P114	5.02	Yes	Yes	3	3	8
369	V:V:K95	V:V:T116	7.51	Yes	No	0	3	4
370	V:V:E102	V:V:L97	3.98	No	No	0	6	4
371	V:V:L97	V:V:P114	3.28	No	Yes	3	4	8
372	V:V:Q101	V:V:T98	4.25	Yes	No	3	9	8
373	V:V:R103	V:V:R99	3.2	No	No	0	6	4
374	V:V:P114	V:V:Q101	4.74	Yes	Yes	3	8	9
375	V:V:E102	V:V:I105	4.1	No	No	0	6	4
376	V:V:E102	V:V:K106	9.45	No	No	0	6	6
377	V:V:I105	V:V:P114	5.08	No	Yes	3	4	8
378	V:V:K107	V:V:L108	2.82	No	Yes	0	9	8
379	V:V:A112	V:V:L108	3.15	No	Yes	0	8	8
380	V:V:E110	V:V:H111	8.62	No	No	0	3	6
381	V:V:F115	V:V:F117	5.36	Yes	Yes	10	9	8
382	V:V:I119	V:V:P120	3.39	Yes	Yes	0	5	7
383	V:V:P120	V:V:P121	1.95	Yes	No	0	7	4
384	V:V:L123	V:V:P120	4.93	Yes	Yes	2	6	7
385	V:V:A310	V:V:N122	4.69	No	No	0	4	5
386	V:V:I314	V:V:N122	4.25	No	No	0	5	5
387	V:V:L123	V:V:P124	4.93	Yes	Yes	2	6	9
388	V:V:L123	V:V:Y144	3.52	Yes	Yes	2	6	7
389	V:V:K170	V:V:L123	2.82	No	Yes	2	9	6
390	V:V:P124	V:V:V142	1.77	Yes	Yes	2	9	9
391	V:V:P124	V:V:Y144	2.78	Yes	Yes	2	9	7
392	V:V:I314	V:V:P124	5.08	No	Yes	0	5	9
393	V:V:Q172	V:V:S125	5.78	Yes	No	22	9	7
394	V:V:S125	V:V:T304	3.2	No	No	22	7	9
395	V:V:E169	V:V:S126	5.75	No	No	0	9	9
396	V:V:G291	V:V:S126	3.71	No	No	0	9	9
397	V:V:I317	V:V:V127	6.14	Yes	No	0	8	8
398	V:V:G141	V:V:T128	1.82	No	Yes	0	9	6
399	V:V:D143	V:V:T128	2.89	No	Yes	0	7	6
400	V:V:G291	V:V:T128	1.82	No	Yes	0	9	6
401	V:V:K292	V:V:T128	6.01	Yes	Yes	0	6	6
402	V:V:I140	V:V:L129	7.14	No	Yes	2	9	8
403	V:V:I241	V:V:L129	2.85	Yes	Yes	2	8	8
404	V:V:I317	V:V:L129	4.28	Yes	Yes	2	8	8
405	V:V:P131	V:V:Q130	3.16	No	Yes	0	8	9
406	V:V:Q130	V:V:R282	2.34	Yes	No	0	9	6
407	V:V:L287	V:V:Q130	6.65	Yes	Yes	0	7	9
408	V:V:L289	V:V:Q130	7.99	Yes	Yes	0	9	9
409	V:V:G132	V:V:P133	4.06	No	No	0	6	4
410	V:V:G132	V:V:R285	3	No	No	0	6	7
411	V:V:G316	V:V:V142	1.84	No	Yes	2	8	9
412	V:V:I317	V:V:V142	3.07	Yes	Yes	2	8	9
413	V:V:K170	V:V:Y144	2.39	No	Yes	2	9	7
414	V:V:E145	V:V:R165	4.65	No	No	0	7	5
415	V:V:I168	V:V:V146	4.61	No	No	0	8	6
416	V:V:F149	V:V:K147	9.93	Yes	No	16	5	7
417	V:V:I158	V:V:K147	4.36	No	No	16	5	7
418	V:V:F149	V:V:I158	15.07	Yes	No	16	5	5
419	V:V:A151	V:V:E156	3.02	No	No	0	6	6
420	V:V:E152	V:V:N153	5.26	No	No	0	4	4
421	V:V:E152	V:V:E156	15.22	No	No	0	4	6
422	V:V:E155	V:V:L154	2.65	No	Yes	0	4	3
423	V:V:E156	V:V:K157	6.75	No	No	0	6	6
424	V:V:I158	V:V:S163	6.19	No	No	0	5	8
425	V:V:H159	V:V:R161	2.26	No	No	9	5	7
426	V:V:H159	V:V:N162	2.55	No	No	9	5	8
427	V:V:K160	V:V:S163	3.06	No	No	0	8	8
428	V:V:K160	V:V:R165	2.48	No	No	0	8	5
429	V:V:N162	V:V:R161	2.41	No	No	9	8	7
430	V:V:E169	V:V:L293	7.95	No	Yes	20	9	8
431	V:V:E169	V:V:H362	6.15	No	No	20	9	1
432	V:V:V171	V:V:Y173	3.79	No	Yes	0	6	4
433	V:V:Q172	V:V:T304	7.09	Yes	No	22	9	9
434	V:V:L305	V:V:Q172	3.99	No	Yes	0	5	9
435	V:V:H353	V:V:Y173	2.18	Yes	Yes	0	8	4
436	V:V:P356	V:V:Y173	15.3	No	Yes	21	9	4
437	V:V:P360	V:V:Y173	2.78	Yes	Yes	21	1	4
438	V:V:A174	V:V:P175	1.87	No	No	0	9	9
439	V:V:I207	V:V:P175	3.39	No	No	0	5	9
440	V:V:P178	V:V:R177	4.32	No	No	0	4	3
441	V:V:G179	V:V:P180	4.06	No	No	0	6	4
442	V:V:E206	V:V:G179	3.27	No	No	0	7	6
443	V:V:P182	V:V:Q181	3.16	Yes	No	0	9	7
444	V:V:Q181	V:V:T183	4.25	No	No	0	7	4
445	V:V:Q181	V:V:S202	4.33	No	No	0	7	7
446	V:V:L203	V:V:P182	11.49	No	Yes	0	8	9
447	V:V:E206	V:V:P182	3.14	No	Yes	0	7	9
448	V:V:E185	V:V:T187	4.23	No	No	0	5	5
449	V:V:E185	V:V:H198	13.54	No	No	24	5	6
450	V:V:E185	V:V:E200	5.07	No	No	24	5	7
451	V:V:L199	V:V:T186	2.95	Yes	No	25	6	7
452	V:V:T186	V:V:V345	4.76	No	No	25	7	7
453	V:V:F190	V:V:R188	10.69	No	Yes	0	9	8
454	V:V:R188	V:V:S341	7.91	Yes	No	0	8	8
455	V:V:R188	V:V:V343	9.15	Yes	No	0	8	7
456	V:V:M192	V:V:Q189	4.08	No	No	0	7	6
457	V:V:F190	V:V:L191	2.44	No	No	0	9	5
458	V:V:F190	V:V:K226	8.69	No	Yes	0	9	8
459	V:V:M192	V:V:T224	6.02	No	Yes	15	7	9
460	V:V:M192	V:V:N225	4.21	No	No	15	7	5
461	V:V:D194	V:V:K195	4.15	No	No	0	6	7
462	V:V:K195	V:V:N223	11.19	No	No	0	7	6
463	V:V:L197	V:V:N222	4.12	No	Yes	0	7	9
464	V:V:E200	V:V:H198	12.31	No	No	24	7	6
465	V:V:L199	V:V:L327	4.15	Yes	Yes	0	6	7
466	V:V:L199	V:V:V343	2.98	Yes	No	0	6	7
467	V:V:L199	V:V:V345	4.47	Yes	No	25	6	7
468	V:V:N217	V:V:S202	2.98	No	No	0	6	7
469	V:V:L203	V:V:Y208	3.52	No	Yes	0	8	6
470	V:V:L203	V:V:V216	2.98	No	No	0	8	7
471	V:V:D204	V:V:Y208	3.45	No	Yes	0	6	6
472	V:V:D204	V:V:S215	7.36	No	No	0	6	4
473	V:V:K205	V:V:Y208	10.75	No	Yes	0	8	6
474	V:V:E212	V:V:K205	5.4	No	No	0	8	8
475	V:V:E206	V:V:T350	5.64	No	No	0	7	4
476	V:V:I207	V:V:T350	3.04	No	No	0	5	4
477	V:V:I214	V:V:Y208	7.25	Yes	Yes	6	8	6
478	V:V:F349	V:V:Y208	4.13	Yes	Yes	6	7	6
479	V:V:E212	V:V:Y209	13.47	No	No	0	8	6
480	V:V:P354	V:V:Y209	2.78	No	No	0	8	6
481	V:V:H210	V:V:S302	5.58	No	No	0	9	9
482	V:V:H210	V:V:L351	6.43	No	No	0	9	8
483	V:V:H210	V:V:H353	21.5	No	Yes	0	9	8
484	V:V:E212	V:V:P213	3.14	No	No	0	8	4
485	V:V:I214	V:V:L274	4.28	Yes	No	0	8	5
486	V:V:I214	V:V:P276	6.77	Yes	No	0	8	9
487	V:V:F349	V:V:I214	5.02	Yes	Yes	6	7	8
488	V:V:N217	V:V:V271	2.96	No	No	0	6	5
489	V:V:V218	V:V:Y272	2.52	No	Yes	0	7	4
490	V:V:H219	V:V:S269	9.76	No	No	0	5	5
491	V:V:L327	V:V:V220	4.47	Yes	No	0	7	6
492	V:V:T221	V:V:T267	4.71	No	No	0	5	6
493	V:V:N222	V:V:T224	5.85	Yes	Yes	15	9	9
494	V:V:K226	V:V:N222	8.39	Yes	Yes	15	8	9
495	V:V:N222	V:V:V228	4.43	Yes	No	0	9	8
496	V:V:N225	V:V:T224	5.85	No	Yes	15	5	9
497	V:V:K226	V:V:T224	10.51	Yes	Yes	15	8	9
498	V:V:K226	V:V:N225	2.8	Yes	No	15	8	5
499	V:V:K226	V:V:V329	10.62	Yes	No	0	8	6
500	V:V:P264	V:V:T227	3.5	No	No	0	5	5
501	V:V:S330	V:V:T227	3.2	No	No	0	6	5
502	V:V:V228	V:V:V262	8.02	No	No	0	8	7
503	V:V:L327	V:V:V228	2.98	Yes	No	0	7	8
504	V:V:K229	V:V:S330	4.59	No	No	0	8	6
505	V:V:E257	V:V:K230	2.7	No	No	0	6	5
506	V:V:D259	V:V:K230	2.77	No	No	0	3	5
507	V:V:F268	V:V:I231	2.51	Yes	No	7	5	6
508	V:V:I231	V:V:Y272	2.42	No	Yes	7	6	4
509	V:V:I231	V:V:L327	7.14	No	Yes	0	6	7
510	V:V:K232	V:V:M255	2.88	No	No	26	6	3
511	V:V:E257	V:V:K232	12.15	No	No	26	6	6
512	V:V:K232	V:V:K326	14.37	No	Yes	0	6	7
513	V:V:E256	V:V:I233	9.56	No	Yes	7	4	5
514	V:V:I233	V:V:Y272	6.04	Yes	Yes	7	5	4
515	V:V:I233	V:V:L274	4.28	Yes	No	0	5	5
516	V:V:I233	V:V:V325	3.07	Yes	No	0	5	8
517	V:V:K324	V:V:S234	4.59	Yes	No	0	6	5
518	V:V:V235	V:V:V253	3.21	Yes	No	0	8	9
519	V:V:A254	V:V:V235	3.39	No	Yes	0	7	8
520	V:V:L274	V:V:V235	5.96	No	Yes	0	5	8
521	V:V:V235	V:V:V323	3.21	Yes	No	6	8	7
522	V:V:F349	V:V:V235	2.62	Yes	Yes	6	7	8
523	V:V:R236	V:V:Y238	13.38	Yes	Yes	5	5	4
524	V:V:K250	V:V:R236	13.61	No	Yes	5	5	5
525	V:V:K324	V:V:R236	6.19	Yes	Yes	5	6	5
526	V:V:E346	V:V:R236	2.33	No	Yes	5	8	5
527	H:H:?701	V:V:R236	10.18	Yes	Yes	5	0	5
528	V:V:Q237	V:V:V253	4.3	Yes	No	0	9	9
529	V:V:L287	V:V:Q237	5.32	Yes	Yes	0	7	9
530	V:V:Q237	V:V:V319	4.3	Yes	No	6	9	8
531	V:V:Q237	V:V:Y321	20.29	Yes	Yes	6	9	9
532	V:V:Q248	V:V:Y238	10.15	No	Yes	0	6	4
533	V:V:K250	V:V:Y238	11.94	No	Yes	5	5	4
534	V:V:S320	V:V:Y238	5.09	No	Yes	0	8	4
535	V:V:K322	V:V:Y238	10.75	No	Yes	5	5	4
536	V:V:E346	V:V:Y238	10.1	No	Yes	5	8	4
537	V:V:A239	V:V:I241	3.25	No	Yes	0	8	8
538	V:V:D240	V:V:Q248	5.22	No	No	0	6	6
539	V:V:D240	V:V:I318	5.6	No	No	0	6	5
540	V:V:I241	V:V:Y249	3.63	Yes	No	0	8	7
541	V:V:I241	V:V:I317	8.83	Yes	Yes	2	8	8
542	V:V:T246	V:V:V242	3.17	No	No	0	7	6
543	V:V:F244	V:V:L243	4.87	No	Yes	0	8	7
544	V:V:F244	V:V:N245	2.42	No	No	0	8	8
545	V:V:P252	V:V:V251	3.53	No	No	0	4	6
546	V:V:L287	V:V:V251	2.98	Yes	No	0	7	6
547	V:V:P276	V:V:V253	1.77	No	No	0	9	9
548	V:V:E257	V:V:M255	5.41	No	No	26	6	3
549	V:V:E256	V:V:Y272	7.86	No	Yes	7	4	4
550	V:V:A258	V:V:D260	3.09	No	No	7	5	6
551	V:V:A258	V:V:Y272	4	No	Yes	7	5	4
552	V:V:D260	V:V:F268	8.36	No	Yes	7	6	5
553	V:V:D260	V:V:Y272	3.45	No	Yes	7	6	4
554	V:V:F268	V:V:V262	5.24	Yes	No	0	5	7
555	V:V:A263	V:V:P264	1.87	No	No	0	4	5
556	V:V:A263	V:V:S266	3.42	No	No	0	4	6
557	V:V:F268	V:V:K270	8.69	Yes	No	7	5	8
558	V:V:F268	V:V:Y272	2.06	Yes	Yes	7	5	4
559	V:V:K270	V:V:Y272	3.58	No	Yes	7	8	4
560	V:V:P276	V:V:T275	3.5	No	No	0	9	4
561	V:V:F277	V:V:T275	5.19	No	No	0	3	4
562	V:V:A279	V:V:F277	2.77	No	No	0	4	3
563	V:V:F277	V:V:N280	12.08	No	No	0	3	4
564	V:V:N280	V:V:N281	6.81	No	No	0	4	9
565	V:V:K284	V:V:N281	11.19	No	No	0	8	9
566	V:V:E283	V:V:R282	3.49	No	No	0	5	6
567	V:V:G286	V:V:R285	3	No	No	2	9	7
568	V:V:L287	V:V:L300	4.15	Yes	No	0	7	9
569	V:V:K292	V:V:L289	4.23	Yes	Yes	23	6	9
570	V:V:L289	V:V:T298	7.37	Yes	No	23	9	8
571	V:V:D290	V:V:T298	5.78	No	No	0	9	8
572	V:V:A301	V:V:D290	6.18	No	No	0	9	9
573	V:V:E296	V:V:K292	6.75	No	Yes	0	7	6
574	V:V:K292	V:V:T298	4.5	Yes	No	23	6	8
575	V:V:E296	V:V:L293	10.6	No	Yes	0	7	8
576	V:V:H362	V:V:L293	5.14	No	Yes	20	1	8
577	V:V:H353	V:V:N299	10.2	Yes	No	0	8	8
578	V:V:M352	V:V:S302	4.6	No	No	0	8	9
579	V:V:S303	V:V:Y321	6.36	No	Yes	0	8	9
580	V:V:L305	V:V:M352	4.24	No	No	0	5	8
581	V:V:A310	V:V:R307	2.77	No	No	0	4	4
582	V:V:E308	V:V:G309	3.27	No	No	0	3	4
583	V:V:E313	V:V:N311	3.94	No	No	0	7	4
584	V:V:V319	V:V:Y321	5.05	No	Yes	6	8	9
585	V:V:F349	V:V:Y321	6.19	Yes	Yes	6	7	9
586	V:V:L351	V:V:Y321	2.34	No	Yes	6	8	9
587	V:V:E346	V:V:K322	16.2	No	No	5	8	5
588	V:V:K322	V:V:P348	8.36	No	No	0	5	9
589	V:V:F349	V:V:V323	3.93	Yes	No	6	7	7
590	V:V:K324	V:V:K326	5.75	Yes	Yes	0	6	7
591	V:V:A344	V:V:K324	4.82	No	Yes	0	4	6
592	H:H:?701	V:V:K324	7.09	Yes	Yes	5	0	6
593	V:V:D342	V:V:K326	2.77	No	Yes	0	7	7
594	V:V:A339	V:V:R331	5.53	No	No	0	4	5
595	V:V:R331	V:V:S341	3.95	No	No	0	5	8
596	H:H:?701	V:V:D342	4.55	Yes	No	0	0	7
597	V:V:F349	V:V:L351	3.65	Yes	No	6	7	8
598	V:V:M352	V:V:T350	3.01	No	No	0	8	4
599	V:V:H353	V:V:P354	4.58	Yes	No	0	8	8
600	V:V:K355	V:V:P356	3.35	No	No	0	6	9
601	V:V:P356	V:V:P360	3.9	No	Yes	21	9	1
602	V:V:E358	V:V:E359	5.07	No	No	0	1	1
603	V:V:E359	V:V:P360	3.14	No	Yes	0	1	1
604	V:V:P360	V:V:P361	1.95	Yes	No	0	1	1
605	V:V:P361	V:V:V365	3.53	No	No	0	1	1
606	V:V:R363	V:V:V365	3.92	No	No	0	1	1
607	V:V:E367	V:V:R363	3.49	No	No	0	1	1
608	V:V:E364	V:V:P366	4.72	No	No	0	1	1
609	V:V:E364	V:V:H368	8.62	No	No	0	1	1
610	V:V:P366	V:V:V365	5.3	No	No	0	1	1
611	R:R:G246	R:R:I355	1.76	No	Yes	0	9	8
612	V:V:P196	V:V:T187	1.75	No	No	0	6	5
613	R:R:G154	R:R:L153	1.71	No	Yes	0	4	6
614	R:R:A237	R:R:S183	1.71	No	No	0	7	9
615	R:R:G223	R:R:L197	1.71	No	No	0	3	4
616	V:V:G109	V:V:L108	1.71	No	Yes	0	9	8
617	R:R:A227	R:R:V193	1.7	No	No	0	6	5
618	V:V:G16	V:V:N15	1.7	No	Yes	0	5	8
619	V:V:A288	V:V:V127	1.7	No	No	0	9	8
620	V:V:A148	V:V:V164	1.7	No	No	0	6	8
621	V:V:A184	V:V:V345	1.7	No	No	0	5	7
622	V:V:A201	V:V:V216	1.7	No	No	0	7	7
623	V:V:A288	V:V:V319	1.7	No	No	0	9	8
624	V:V:I207	V:V:P178	1.69	No	No	0	5	4
625	V:V:A12	V:V:T19	1.68	No	No	0	5	7
626	V:V:K95	V:V:P96	1.67	Yes	No	0	3	3
627	V:V:K195	V:V:P196	1.67	No	No	0	7	6
628	R:R:C401	R:R:I162	1.64	No	No	0	9	8
629	V:V:L347	V:V:P182	1.64	No	Yes	0	6	9
630	V:V:L347	V:V:P348	1.64	No	No	0	6	9
631	R:R:S139	R:R:S140	1.63	No	No	0	3	4
632	V:V:S266	V:V:V262	1.62	No	No	0	6	7
633	R:R:S150	R:R:T146	1.6	No	No	0	7	7
634	R:R:V279	R:R:V280	1.6	No	No	0	6	2
635	R:R:V284	R:R:V285	1.6	No	No	0	4	5
636	R:R:C224	R:R:L197	1.59	No	No	0	9	4
637	R:R:A155	R:R:L394	1.58	No	No	0	6	5
638	R:R:A178	R:R:L163	1.58	No	No	0	7	8
639	V:V:P91	V:V:Q85	1.58	No	No	0	3	9
640	V:V:E176	V:V:P175	1.57	No	No	0	3	9
641	R:R:A314	R:R:N318	1.56	No	Yes	0	8	9
642	V:V:A310	V:V:N311	1.56	No	No	0	4	4
643	V:V:K229	V:V:V328	1.52	No	No	0	8	4
644	V:V:K326	V:V:V328	1.52	Yes	No	0	7	4
645	R:R:L153	R:R:S189	1.5	Yes	No	0	6	4
646	R:R:N298	R:R:S297	1.49	No	No	0	6	4
647	V:V:N217	V:V:S269	1.49	No	No	0	6	5
648	R:R:L192	R:R:T146	1.47	No	No	0	7	7
649	V:V:D194	V:V:S193	1.47	No	No	0	6	9
650	R:R:D299	R:R:T296	1.45	No	No	0	4	5
651	R:R:I194	R:R:L198	1.43	No	No	0	6	6
652	V:V:I314	V:V:L306	1.43	No	No	0	5	4
653	V:V:K77	V:V:L79	1.41	No	No	0	9	8
654	R:R:L153	R:R:L157	1.38	Yes	No	0	6	3
655	R:R:A222	R:R:R225	1.38	No	No	0	4	8
656	R:R:A335	R:R:R334	1.38	No	No	0	7	7
657	R:R:R417	V:V:A247	1.38	No	No	0	7	8
658	V:V:L278	V:V:L289	1.38	No	Yes	0	8	9
659	V:V:L154	V:V:N153	1.37	Yes	No	0	3	4
660	V:V:H198	V:V:T221	1.37	No	No	0	6	5
661	R:R:E426	R:R:K422	1.35	No	No	0	4	5
662	R:R:R261	R:R:S262	1.32	Yes	No	0	5	5
663	R:R:F230	R:R:V226	1.31	Yes	No	0	4	4
664	R:R:F319	R:R:V360	1.31	No	No	0	7	6
665	R:R:A182	R:R:W272	1.3	No	Yes	0	4	9
666	R:R:D342	R:R:E406	1.3	No	No	0	7	9
667	V:V:D297	V:V:E296	1.3	No	No	0	8	7
668	R:R:S152	R:R:Y149	1.27	No	Yes	0	9	8
669	R:R:V423	V:V:Y63	1.26	No	No	0	3	9
670	V:V:L100	V:V:R103	1.21	No	No	0	5	6
671	R:R:E290	R:R:F303	1.17	No	Yes	0	6	4
672	R:R:E427	R:R:R428	1.16	No	No	0	5	2
673	R:R:F320	R:R:R324	1.07	No	No	0	5	8
674	R:R:F367	R:R:W304	1	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M144	4.105	4	4	6
2	R:R:Y145	4.645	4	4	7
3	R:R:Y149	4.59286	7	4	8
4	R:R:L153	1.935	4	0	6
5	R:R:L156	3.7325	4	0	8
6	R:R:K168	4.6175	4	1	8
7	R:R:R173	5.53	5	1	9
8	R:R:N174	7.4975	4	1	9
9	R:R:H177	7.49	4	1	9
10	R:R:L180	4.255	4	1	9
11	R:R:F181	3.39571	7	1	8
12	R:R:F184	7.10667	6	1	8
13	R:R:F230	3.2375	4	0	4
14	R:R:Y233	5.085	4	0	9
15	R:R:Y239	7.6575	4	17	8
16	R:R:W241	8.855	6	1	9
17	R:R:V244	6.542	5	1	8
18	R:R:L249	4.0125	4	0	9
19	R:R:L253	3.8325	4	8	8
20	R:R:R261	4.2175	4	1	5
21	R:R:F263	4.2975	4	1	5
22	R:R:Y267	4.775	6	1	7
23	R:R:G271	2.865	4	1	9
24	R:R:W272	2.5625	4	0	9
25	R:R:P275	3.422	5	1	9
26	R:R:W282	10.02	6	11	9
27	R:R:W295	6.85	5	0	9
28	R:R:F303	8.825	4	11	4
29	R:R:W304	5.685	4	18	6
30	R:R:R308	4.8175	4	0	6
31	R:R:I315	3.9825	4	17	7
32	R:R:N318	5.58	4	12	9
33	R:R:K344	7.89333	6	8	6
34	R:R:R346	5.854	5	1	8
35	R:R:L354	4.38	4	0	9
36	R:R:I355	3.572	5	12	8
37	R:R:H361	7.7125	4	1	8
38	R:R:F383	10.205	4	4	5
39	R:R:Q392	5.9125	4	1	9
40	R:R:V396	4.8125	4	1	9
41	R:R:Y400	8.57	6	1	8
42	R:R:E410	4.5	5	1	8
43	R:R:W425	5.26167	6	2	2
44	V:V:N15	4.778	5	9	8
45	V:V:V20	2.9475	4	10	6
46	V:V:Y21	5.40167	6	3	8
47	V:V:R25	5.51	4	0	9
48	V:V:D26	7.1975	4	0	9
49	V:V:V40	3.475	6	3	8
50	V:V:Y54	7.8225	4	0	4
51	V:V:L57	5.485	4	0	7
52	V:V:F61	4.5125	4	2	9
53	V:V:D78	5.1	4	14	8
54	V:V:F80	5.15	4	2	4
55	V:V:F87	10.4475	4	13	4
56	V:V:P88	7.5775	4	13	9
57	V:V:K95	4.6075	4	3	3
58	V:V:Q101	3.814	5	3	9
59	V:V:L108	4.754	5	0	8
60	V:V:P114	3.978	5	3	8
61	V:V:F115	6.075	4	10	9
62	V:V:F117	6.22333	6	10	8
63	V:V:I119	4.2475	4	0	5
64	V:V:P120	5.4575	4	2	7
65	V:V:L123	3.728	5	2	6
66	V:V:P124	3.64	4	2	9
67	V:V:T128	3.135	4	0	6
68	V:V:L129	4.1375	4	2	8
69	V:V:Q130	5.035	4	0	9
70	V:V:V142	2.6525	4	2	9
71	V:V:Y144	4.5075	4	2	7
72	V:V:F149	8.58	4	16	5
73	V:V:L154	4.38	4	0	3
74	V:V:L166	5.8525	4	10	8
75	V:V:Q172	5.8475	4	22	9
76	V:V:Y173	5.314	5	21	4
77	V:V:P182	4.8575	4	0	9
78	V:V:R188	8.065	4	0	8
79	V:V:L199	3.6375	4	25	6
80	V:V:Y208	5.82	5	6	6
81	V:V:I214	5.83	4	6	8
82	V:V:N222	5.6975	4	15	9
83	V:V:T224	7.0575	4	15	9
84	V:V:K226	8.202	5	15	8
85	V:V:I233	5.7375	4	7	5
86	V:V:V235	3.678	5	6	8
87	V:V:R236	9.138	5	5	5
88	V:V:Q237	8.5525	4	6	9
89	V:V:Y238	10.235	6	5	4
90	V:V:I241	4.64	4	2	8
91	V:V:L243	5.19	4	0	7
92	V:V:F268	5.372	5	7	5
93	V:V:Y272	3.99125	8	7	4
94	V:V:L287	4.775	4	0	7
95	V:V:L289	5.2425	4	23	9
96	V:V:K292	5.3725	4	23	6
97	V:V:L293	7.1375	4	20	8
98	V:V:I317	5.468	5	2	8
99	V:V:Y321	8.046	5	6	9
100	V:V:K324	5.688	5	5	6
101	V:V:K326	6.1025	4	0	7
102	V:V:L327	4.685	4	0	7
103	V:V:F349	4.25667	6	6	7
104	V:V:H353	9.615	4	0	8
105	V:V:P360	4.608	5	21	1
106	H:H:?701	7.368	5	5	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y145	R:R:Y149	10.9281	1.99	Yes	Yes	4	7	8
2	R:R:K187	R:R:Y149	24.3717	2.39	No	Yes	0	8	8
3	R:R:L180	R:R:W241	57.603	6.83	Yes	Yes	1	9	9
4	R:R:G271	R:R:W241	36.9702	5.63	Yes	Yes	1	9	9
5	R:R:G271	R:R:P275	37.4755	2.03	Yes	Yes	1	9	9
6	R:R:P275	R:R:V236	35.0359	1.77	Yes	No	0	9	6
7	R:R:V236	R:R:V311	33.5134	3.21	No	No	0	6	8
8	R:R:V311	R:R:Y239	27.8234	7.57	No	Yes	0	8	8
9	R:R:I235	R:R:Y239	25.4201	3.63	No	Yes	0	5	8
10	R:R:I235	R:R:K187	24.8963	5.82	No	No	0	5	8
11	R:R:L180	R:R:Y400	65.2073	2.34	Yes	Yes	1	9	8
12	V:V:K322	V:V:P348	13.9564	8.36	No	No	0	5	9
13	V:V:L347	V:V:P348	14.2844	1.64	No	No	0	6	9
14	V:V:L347	V:V:P182	14.6129	1.64	No	Yes	0	6	9
15	V:V:L203	V:V:P182	13.0307	11.49	No	Yes	0	8	9
16	V:V:L203	V:V:Y208	13.5912	3.52	No	Yes	0	8	6
17	V:V:F349	V:V:Y208	14.4957	4.13	Yes	Yes	6	7	6
18	V:V:F349	V:V:Y321	34.6759	6.19	Yes	Yes	6	7	9
19	V:V:V319	V:V:Y321	37.9352	5.05	No	Yes	6	8	9
20	V:V:A288	V:V:V319	55.5437	1.7	No	No	0	9	8
21	V:V:A288	V:V:V127	55.6553	1.7	No	No	0	9	8
22	V:V:I317	V:V:V127	55.7936	6.14	Yes	No	0	8	8
23	V:V:F61	V:V:I317	52.0372	5.02	Yes	Yes	2	9	8
24	V:V:F61	V:V:L243	98.9346	6.09	Yes	Yes	0	9	7
25	V:V:F244	V:V:L243	100	4.87	No	Yes	0	8	7
26	V:V:F244	V:V:N245	99.9336	2.42	No	No	0	8	8
27	R:R:H416	V:V:N245	99.8665	20.41	No	No	0	3	8
28	R:R:H416	R:R:R412	99.7987	2.26	No	No	0	3	5
29	R:R:Q408	R:R:R412	99.6608	3.5	No	No	0	7	5
30	R:R:K405	R:R:Q408	99.5907	4.07	No	No	0	6	7
31	R:R:E406	R:R:K405	99.5199	2.7	No	No	0	9	6
32	R:R:E406	R:R:N404	99.3761	3.94	No	No	0	9	9
33	R:R:N404	R:R:R346	99.3031	15.67	No	Yes	0	9	8
34	R:R:H177	R:R:R346	49.3403	2.26	Yes	Yes	1	9	8
35	R:R:H177	R:R:Y400	37.1989	22.87	Yes	Yes	1	9	8
36	R:R:R346	R:R:S350	37.7443	5.27	Yes	No	0	8	9
37	R:R:S350	R:R:Y400	37.1667	5.09	No	Yes	0	9	8
38	V:V:I231	V:V:L327	17.8162	7.14	No	Yes	0	6	7
39	V:V:I231	V:V:Y272	18.4801	2.42	No	Yes	7	6	4
40	V:V:I233	V:V:Y272	35.3057	6.04	Yes	Yes	7	5	4
41	V:V:I233	V:V:L274	37.3302	4.28	Yes	No	0	5	5
42	V:V:I214	V:V:L274	12.934	4.28	Yes	No	0	8	5
43	V:V:F349	V:V:I214	12.5959	5.02	Yes	Yes	6	7	8
44	V:V:L274	V:V:V235	25.0705	5.96	No	Yes	0	5	8
45	V:V:F349	V:V:V235	12.5662	2.62	Yes	Yes	6	7	8
46	V:V:V235	V:V:V253	13.5438	3.21	Yes	No	0	8	9
47	V:V:Q237	V:V:V253	15.4192	4.3	Yes	No	0	9	9
48	V:V:Q237	V:V:V319	17.5344	4.3	Yes	No	6	9	8
49	R:R:L347	R:R:R173	12.1703	7.29	No	Yes	1	9	9
50	R:R:F184	R:R:Q392	16.0679	3.51	Yes	Yes	1	8	9
51	R:R:L307	R:R:W282	11.6458	9.11	No	Yes	11	7	9
52	R:R:L307	R:R:V279	12.7464	5.96	No	No	0	7	6
53	R:R:V279	R:R:Y233	14.3801	10.09	No	Yes	0	6	9
54	R:R:W272	R:R:Y233	17.553	3.86	Yes	Yes	0	9	9
55	R:R:W241	R:R:W272	19.1641	2.81	Yes	Yes	0	9	9
56	R:R:E245	R:R:Y400	10.2953	10.1	No	Yes	0	9	8
57	V:V:F61	V:V:V142	46.8974	3.93	Yes	Yes	2	9	9
58	V:V:P124	V:V:V142	50.7468	1.77	Yes	Yes	2	9	9
59	V:V:L123	V:V:P124	45.2425	4.93	Yes	Yes	2	6	9
60	V:V:F80	V:V:L123	40.1079	2.44	Yes	Yes	2	4	6
61	V:V:F80	V:V:L57	20.2884	2.44	Yes	Yes	0	4	7
62	V:V:F117	V:V:L57	22.8759	12.18	Yes	Yes	0	8	7
63	V:V:F115	V:V:F117	43.4631	5.36	Yes	Yes	10	9	8
64	V:V:F115	V:V:G39	21.2089	4.52	Yes	No	0	9	8
65	V:V:G39	V:V:Q101	20.6791	3.29	No	Yes	0	8	9
66	V:V:Q101	V:V:V40	10.9106	2.87	Yes	Yes	3	9	8
67	V:V:A82	V:V:F80	19.8617	4.16	No	Yes	0	4	4
68	V:V:A82	V:V:F117	19.6449	2.77	No	Yes	0	4	8
69	V:V:F115	V:V:V20	28.3735	2.62	Yes	Yes	10	9	6
70	V:V:L166	V:V:V20	11.8745	2.98	Yes	Yes	10	8	6
71	V:V:V20	V:V:V41	19.4528	3.21	Yes	No	0	6	5
72	V:V:S86	V:V:V41	18.9579	3.23	No	No	0	6	5
73	V:V:S86	V:V:Y113	17.9682	2.54	No	No	0	6	3
74	V:V:L287	V:V:Q237	10.2886	5.32	Yes	Yes	0	7	9
75	V:V:H210	V:V:L351	10.2308	6.43	No	No	0	9	8
76	V:V:D29	V:V:Q172	12.141	6.53	No	Yes	0	9	9
77	V:V:L305	V:V:Q172	11.1012	3.99	No	Yes	0	5	9
78	V:V:L305	V:V:M352	11.2194	4.24	No	No	0	5	8
79	V:V:M352	V:V:T350	10.2289	3.01	No	No	0	8	4
80	V:V:N222	V:V:V228	15.2613	4.43	Yes	No	0	9	8
81	V:V:F268	V:V:Y272	13.4974	2.06	Yes	Yes	7	5	4
82	V:V:F268	V:V:V262	12.8798	5.24	Yes	No	0	5	7
83	R:R:F181	R:R:H177	12.2648	2.26	Yes	Yes	1	8	9
84	R:R:L347	R:R:R346	12.1399	3.64	No	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8JRU

PDB Summary
PDB	8JRU
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	Glucagon
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	Arrestin2
PDB Resolution	3.5
Date	2023-08-16
D.O.I.	doi.org/10.1038/s41586-023-06420-x

Net Summary
I_min	1.77
Number of Linked Nodes	563
Number of Links	674
Number of Hubs	106
Number of Links mediated by Hubs	386
Number of Communities	26
Number of Nodes involved in Communities	172
Number of Links involved in Communities	222

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	412919
Length Of Smallest Path	3
Average Path Length	26.1801
Length of Longest Path	51
Minimum Path Strength	1.44
Average Path Strength	5.44366
Maximum Path Strength	21.895
Minimum Path Correlation	0.7
Average Path Correlation	0.96628
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	45.8453
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.658
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• clathrin binding • protein binding • binding • protein-containing complex binding • AP-2 adaptor complex binding • clathrin heavy chain binding • signaling receptor binding • acetylcholine receptor binding • small molecule binding • ion binding • phosphatidylinositol-3,4,5-trisphosphate binding • anion binding • phospholipid binding • lipid binding • phosphatidylinositol phosphate binding • phosphatidylinositol binding • molecular adaptor activity • G protein-coupled receptor binding • inositol hexakisphosphate binding • alcohol binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • biological regulation • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • establishment of protein localization • protein transport • macromolecule localization • intracellular protein localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • cellular component organization • positive regulation of endocytosis • cellular component organization or biogenesis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • negative adaptation of signaling pathway • negative regulation of signaling • negative regulation of biological process • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception • nervous system process • clathrin-dependent endocytosis • cell surface receptor signaling pathway • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • catabolic process • primary metabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • metabolic process • protein metabolic process • macromolecule metabolic process • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of metabolic process • G protein-coupled receptor internalization • cell projection • cellular anatomical structure • pseudopodium • plasma membrane bounded cell projection • protein-containing complex • intracellular anatomical structure • plasma membrane protein complex • membrane • plasma membrane • membrane protein complex • coated membrane • endomembrane system • clathrin coat • membrane coat
Gene Ontology	Cellular Component	• cell projection • cellular anatomical structure • pseudopodium • plasma membrane bounded cell projection • protein-containing complex • intracellular anatomical structure • plasma membrane protein complex • membrane • plasma membrane • membrane protein complex • coated membrane • endomembrane system • clathrin coat • membrane coat • cell periphery • clathrin-coated pit • cytoplasm • clathrin coat of coated pit • cytosol • membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle • organelle • intracellular vesicle • intracellular membrane-bounded organelle • vesicle • nucleus • identical protein binding • protein binding • binding • host cell surface binding • host cell surface receptor binding • cation binding • ion binding • calcium ion binding • metal ion binding • small molecule binding • peptidase activity • catalytic activity, acting on a protein • serine hydrolase activity • serine-type peptidase activity • hydrolase activity • serine-type endopeptidase activity • catalytic activity • endopeptidase activity • vasopressin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • glucagon receptor activity • peptide hormone binding • hormone binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • cellular component organization • membrane fusion • fusion of virus membrane with host plasma membrane • cellular process • cellular component organization or biogenesis • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • transport • establishment of localization • vesicle-mediated transport • localization • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • multicellular organismal process • regulation of body fluid levels • wound healing • response to stimulus • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of biological process • regulation of cellular process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • regulation of response to wounding • regulation of coagulation • regulation of multicellular organismal process • regulation of hemostasis • negative regulation of wound healing • regulation of blood coagulation • negative regulation of blood coagulation • negative regulation of response to wounding • negative regulation of hemostasis • negative regulation of coagulation • regulation of wound healing • negative regulation of multicellular organismal process • regulation of establishment of endothelial barrier • cellular developmental process • regulation of developmental process • positive regulation of endothelial cell development • endothelium development • positive regulation of biological process • cell development • regulation of cell differentiation • epithelial cell differentiation • regulation of cell development • regulation of epithelial cell differentiation • endothelial cell development • positive regulation of developmental process • multicellular organism development • positive regulation of cell differentiation • cell differentiation • regulation of endothelial cell development • anatomical structure development • positive regulation of cellular process • developmental process • epithelium development • regulation of multicellular organismal development • endothelial cell differentiation • regulation of endothelial cell differentiation • positive regulation of cell development • positive regulation of establishment of endothelial barrier • tissue development • epithelial cell development • establishment of endothelial barrier • proteolysis • metabolic process • primary metabolic process • protein metabolic process • macromolecule metabolic process • regulation of tube diameter • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • renal system process • homeostatic process • fluid transport • water transport • renal water transport • multicellular organismal-level homeostasis • chemical homeostasis • renal absorption • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water absorption • renal water homeostasis • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • regulation of metabolic process • cellular response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of cell communication • positive regulation of signaling • regulation of urine volume • renal water retention • negative regulation of urine volume • head development • forebrain development • animal organ development • brain development • nervous system development • central nervous system development • telencephalon development • system development • negative regulation of cell population proliferation • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • cellular response to nutrient levels • response to nutrient levels • cellular response to stress • response to starvation • cellular response to starvation • cell surface receptor signaling pathway • response to nutrient • glucose homeostasis • carbohydrate homeostasis • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part • Golgi apparatus • membrane-enclosed lumen • intracellular organelle lumen • Golgi lumen • organelle lumen • endoplasmic reticulum lumen • endoplasmic reticulum • extracellular region • extracellular space • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • endosome • perinuclear region of cytoplasm
SCOP2	Domain Identifier	• Arrestin/Vps26-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Arrestin/Vps26-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PIO
PDB Residues	H:H:?701
Environment Details	Open EMBL-EBI Page
Code	PIO
Name	[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Synonyms	dioctanoyl l-alpha-phosphatidyl-d-myo-inositol 4,5-diphosphate
Identifier
Formula	C25 H49 O19 P3
Molecular Weight	746.566
SMILES
PubChem	9543520
Formal Charge	0
Total Atoms	96
Total Chiral Atoms	7
Total Bonds	96
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>8JRU_Chain_R S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N D N M G F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H H T D Y K F R L A K S T L T L I P L L G V H E V V F A F A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H R W R L G K V L W E E R E ?C T ?A ???L A K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P49407
Sequence	>8JRU_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V E P V D G V V L V D P E Y L K E R R V Y V T L T A A F R Y G T F R K D L F V A N V Q S F P P A P K K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P S S V T L Q P G P E D T G K A I G V D Y E V K A F V A E N L E E K I H K R N S V R L V I E K V Q Y A P E R P G P Q P T A E T T R Q F L M S D K P L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I V L F N T A Q Y K V P V A M E E A D D T V A P S S T F S K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V S R G A S S D V A V E L P F T L M H P K P K E E P P H R E V P E H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	doi.org/10.1038/nature12393
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	doi.org/10.1038/nature17414
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	doi.org/10.1038/nature22363
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	doi.org/10.1038/nature22363
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	NNC1702	-	-	3	2018-01-17	doi.org/10.1038/nature25153
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/β1/γ2	3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LMK (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gi1/β1/γ1	3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-	Gs/β1/γ2	3.1	2020-08-12	doi.org/10.1126/science.aba3373
	6WPW (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-		3.1	2020-08-12	doi.org/10.1126/science.aba3373
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide (non-acylated)	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide (non-acylated)	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide (non-acylated)	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V35 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-		3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-	Gs/β1/γ2	2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	8FU6 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	ZP3780	-		2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/β1/γ2	2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIT (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-		2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/β1/γ2	3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIQ (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-		3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/β1/γ2	2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-		2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-		2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/β1/γ2	2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG8 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide		2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	9E2A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	3.3	2025-10-29	To be published
	9E2A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		3.3	2025-10-29	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JRU.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.