Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M144 4.105446
2R:R:Y145 4.645447
3R:R:Y149 4.59286748
4R:R:L153 1.935406
5R:R:L156 3.7325408
6R:R:K168 4.6175418
7R:R:R173 5.53519
8R:R:N174 7.4975419
9R:R:H177 7.49419
10R:R:L180 4.255419
11R:R:F181 3.39571718
12R:R:F184 7.10667618
13R:R:F230 3.2375404
14R:R:Y233 5.085409
15R:R:Y239 7.65754178
16R:R:W241 8.855619
17R:R:V244 6.542518
18R:R:L249 4.0125409
19R:R:L253 3.8325488
20R:R:R261 4.2175415
21R:R:F263 4.2975415
22R:R:Y267 4.775617
23R:R:G271 2.865419
24R:R:W272 2.5625409
25R:R:P275 3.422519
26R:R:W282 10.026119
27R:R:W295 6.85509
28R:R:F303 8.8254114
29R:R:W304 5.6854186
30R:R:R308 4.8175406
31R:R:I315 3.98254177
32R:R:N318 5.584129
33R:R:K344 7.89333686
34R:R:R346 5.854518
35R:R:L354 4.38409
36R:R:I355 3.5725128
37R:R:H361 7.7125418
38R:R:F383 10.205445
39R:R:Q392 5.9125419
40R:R:V396 4.8125419
41R:R:Y400 8.57618
42R:R:E410 4.5518
43R:R:W425 5.26167622
44V:V:N15 4.778598
45V:V:V20 2.94754106
46V:V:Y21 5.40167638
47V:V:R25 5.51409
48V:V:D26 7.1975409
49V:V:V40 3.475638
50V:V:Y54 7.8225404
51V:V:L57 5.485407
52V:V:F61 4.5125429
53V:V:D78 5.14148
54V:V:F80 5.15424
55V:V:F87 10.44754134
56V:V:P88 7.57754139
57V:V:K95 4.6075433
58V:V:Q101 3.814539
59V:V:L108 4.754508
60V:V:P114 3.978538
61V:V:F115 6.0754109
62V:V:F117 6.223336108
63V:V:I119 4.2475405
64V:V:P120 5.4575427
65V:V:L123 3.728526
66V:V:P124 3.64429
67V:V:T128 3.135406
68V:V:L129 4.1375428
69V:V:Q130 5.035409
70V:V:V142 2.6525429
71V:V:Y144 4.5075427
72V:V:F149 8.584165
73V:V:L154 4.38403
74V:V:L166 5.85254108
75V:V:Q172 5.84754229
76V:V:Y173 5.3145214
77V:V:P182 4.8575409
78V:V:R188 8.065408
79V:V:L199 3.63754256
80V:V:Y208 5.82566
81V:V:I214 5.83468
82V:V:N222 5.69754159
83V:V:T224 7.05754159
84V:V:K226 8.2025158
85V:V:I233 5.7375475
86V:V:V235 3.678568
87V:V:R236 9.138555
88V:V:Q237 8.5525469
89V:V:Y238 10.235654
90V:V:I241 4.64428
91V:V:L243 5.19407
92V:V:F268 5.372575
93V:V:Y272 3.99125874
94V:V:L287 4.775407
95V:V:L289 5.24254239
96V:V:K292 5.37254236
97V:V:L293 7.13754208
98V:V:I317 5.468528
99V:V:Y321 8.046569
100V:V:K324 5.688556
101V:V:K326 6.1025407
102V:V:L327 4.685407
103V:V:F349 4.25667667
104V:V:H353 9.615408
105V:V:P360 4.6085211
106H:H:?701 7.368550
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:Y145 R:R:Y149 10.92811.99YesYes478
2R:R:K187 R:R:Y149 24.37172.39NoYes088
3R:R:L180 R:R:W241 57.6036.83YesYes199
4R:R:G271 R:R:W241 36.97025.63YesYes199
5R:R:G271 R:R:P275 37.47552.03YesYes199
6R:R:P275 R:R:V236 35.03591.77YesNo096
7R:R:V236 R:R:V311 33.51343.21NoNo068
8R:R:V311 R:R:Y239 27.82347.57NoYes088
9R:R:I235 R:R:Y239 25.42013.63NoYes058
10R:R:I235 R:R:K187 24.89635.82NoNo058
11R:R:L180 R:R:Y400 65.20732.34YesYes198
12V:V:K322 V:V:P348 13.95648.36NoNo059
13V:V:L347 V:V:P348 14.28441.64NoNo069
14V:V:L347 V:V:P182 14.61291.64NoYes069
15V:V:L203 V:V:P182 13.030711.49NoYes089
16V:V:L203 V:V:Y208 13.59123.52NoYes086
17V:V:F349 V:V:Y208 14.49574.13YesYes676
18V:V:F349 V:V:Y321 34.67596.19YesYes679
19V:V:V319 V:V:Y321 37.93525.05NoYes689
20V:V:A288 V:V:V319 55.54371.7NoNo098
21V:V:A288 V:V:V127 55.65531.7NoNo098
22V:V:I317 V:V:V127 55.79366.14YesNo088
23V:V:F61 V:V:I317 52.03725.02YesYes298
24V:V:F61 V:V:L243 98.93466.09YesYes097
25V:V:F244 V:V:L243 1004.87NoYes087
26V:V:F244 V:V:N245 99.93362.42NoNo088
27R:R:H416 V:V:N245 99.866520.41NoNo038
28R:R:H416 R:R:R412 99.79872.26NoNo035
29R:R:Q408 R:R:R412 99.66083.5NoNo075
30R:R:K405 R:R:Q408 99.59074.07NoNo067
31R:R:E406 R:R:K405 99.51992.7NoNo096
32R:R:E406 R:R:N404 99.37613.94NoNo099
33R:R:N404 R:R:R346 99.303115.67NoYes098
34R:R:H177 R:R:R346 49.34032.26YesYes198
35R:R:H177 R:R:Y400 37.198922.87YesYes198
36R:R:R346 R:R:S350 37.74435.27YesNo089
37R:R:S350 R:R:Y400 37.16675.09NoYes098
38V:V:I231 V:V:L327 17.81627.14NoYes067
39V:V:I231 V:V:Y272 18.48012.42NoYes764
40V:V:I233 V:V:Y272 35.30576.04YesYes754
41V:V:I233 V:V:L274 37.33024.28YesNo055
42V:V:I214 V:V:L274 12.9344.28YesNo085
43V:V:F349 V:V:I214 12.59595.02YesYes678
44V:V:L274 V:V:V235 25.07055.96NoYes058
45V:V:F349 V:V:V235 12.56622.62YesYes678
46V:V:V235 V:V:V253 13.54383.21YesNo089
47V:V:Q237 V:V:V253 15.41924.3YesNo099
48V:V:Q237 V:V:V319 17.53444.3YesNo698
49R:R:L347 R:R:R173 12.17037.29NoYes199
50R:R:F184 R:R:Q392 16.06793.51YesYes189
51R:R:L307 R:R:W282 11.64589.11NoYes1179
52R:R:L307 R:R:V279 12.74645.96NoNo076
53R:R:V279 R:R:Y233 14.380110.09NoYes069
54R:R:W272 R:R:Y233 17.5533.86YesYes099
55R:R:W241 R:R:W272 19.16412.81YesYes099
56R:R:E245 R:R:Y400 10.295310.1NoYes098
57V:V:F61 V:V:V142 46.89743.93YesYes299
58V:V:P124 V:V:V142 50.74681.77YesYes299
59V:V:L123 V:V:P124 45.24254.93YesYes269
60V:V:F80 V:V:L123 40.10792.44YesYes246
61V:V:F80 V:V:L57 20.28842.44YesYes047
62V:V:F117 V:V:L57 22.875912.18YesYes087
63V:V:F115 V:V:F117 43.46315.36YesYes1098
64V:V:F115 V:V:G39 21.20894.52YesNo098
65V:V:G39 V:V:Q101 20.67913.29NoYes089
66V:V:Q101 V:V:V40 10.91062.87YesYes398
67V:V:A82 V:V:F80 19.86174.16NoYes044
68V:V:A82 V:V:F117 19.64492.77NoYes048
69V:V:F115 V:V:V20 28.37352.62YesYes1096
70V:V:L166 V:V:V20 11.87452.98YesYes1086
71V:V:V20 V:V:V41 19.45283.21YesNo065
72V:V:S86 V:V:V41 18.95793.23NoNo065
73V:V:S86 V:V:Y113 17.96822.54NoNo063
74V:V:L287 V:V:Q237 10.28865.32YesYes079
75V:V:H210 V:V:L351 10.23086.43NoNo098
76V:V:D29 V:V:Q172 12.1416.53NoYes099
77V:V:L305 V:V:Q172 11.10123.99NoYes059
78V:V:L305 V:V:M352 11.21944.24NoNo058
79V:V:M352 V:V:T350 10.22893.01NoNo084
80V:V:N222 V:V:V228 15.26134.43YesNo098
81V:V:F268 V:V:Y272 13.49742.06YesYes754
82V:V:F268 V:V:V262 12.87985.24YesNo057
83R:R:F181 R:R:H177 12.26482.26YesYes189
84R:R:L347 R:R:R346 12.13993.64NoYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8JRU
Class B1
SubFamily Peptide
Type Glucagon
SubType Glucagon
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Arrestin2
PDB Resolution 3.5
Date 2023-08-16
D.O.I. doi.org/10.1038/s41586-023-06420-x
Net Summary
Imin 1.77
Number of Linked Nodes 563
Number of Links 674
Number of Hubs 106
Number of Links mediated by Hubs 386
Number of Communities 26
Number of Nodes involved in Communities 172
Number of Links involved in Communities 222
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 412919
Length Of Smallest Path 3
Average Path Length 26.1801
Length of Longest Path 51
Minimum Path Strength 1.44
Average Path Strength 5.44366
Maximum Path Strength 21.895
Minimum Path Correlation 0.7
Average Path Correlation 0.96628
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 45.8453
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.658
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Arrestin/Vps26-like   • G protein-coupled receptor-like
SCOP2Family Identifier• Arrestin/Vps26-like   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePIO
PDB ResiduesH:H:?701
Environment DetailsOpen EMBL-EBI Page
CodePIO
Name[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Synonymsdioctanoyl l-alpha-phosphatidyl-d-myo-inositol 4,5-diphosphate
Identifier
FormulaC25 H49 O19 P3
Molecular Weight746.566
SMILES
PubChem9543520
Formal Charge0
Total Atoms96
Total Chiral Atoms7
Total Bonds96
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47871
Sequence
>8JRU_Chain_R
SSFQVMYTV GYSLSLGAL LLALAILGG LSKLHCTRN AIHANLFAS 
FVLKASSVL VIDGLLRTR AVAGCRVAA VFMQYGIVA NYCWLLVEG 
LYLHNLLGE RSFFSLYLG IGWGAPMLF VVPWAVVKC LFENVQCWT 
SNDNMGFWW ILRFPVFLA ILINFFIFV RIVQLLVAK LRARQMHHT 
DYKFRLAKS TLTLIPLLG VHEVVFAFA KLFFDLFLS SFQGLLVAV 
LYCFLNKEV QSELRRRWH RWRLGKVLW EERE?CT?A ???LAK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainV
ProteinArrestin
UniProtP49407
Sequence
>8JRU_Chain_V
TRVFKKASP NGKLTVYLG KRDFVDHID LVEPVDGVV LVDPEYLKE 
RRVYVTLTA AFRYGTFRK DLFVANVQS FPPAPKKPL TRLQERLIK 
KLGEHAYPF TFEIPPNLP SSVTLQPGP EDTGKAIGV DYEVKAFVA 
ENLEEKIHK RNSVRLVIE KVQYAPERP GPQPTAETT RQFLMSDKP 
LHLEASLDK EIYYHGEPI SVNVHVTNN TNKTVKKIK ISVRQYADI 
VLFNTAQYK VPVAMEEAD DTVAPSSTF SKVYTLTPF LANNREKRG 
LALDGKLKH EDTNLASST LLREGANRE ILGIIVSYK VKVKLVVSR 
GASSDVAVE LPFTLMHPK PKEEPPHRE VPEH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiens-Peptide2.712024-03-06doi.org/10.1038/s41421-024-00649-0
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-24doi.org/10.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-24doi.org/10.1038/nature22363
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-20doi.org/10.1038/nature17414
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatideLSN3556672chim(NtGi1-Gs)/β1/γ23.082022-04-13doi.org/10.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatideLSN35566723.082022-04-13doi.org/10.1073/pnas.2116506119
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-18doi.org/10.1038/s41467-020-18945-0
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-06doi.org/10.1038/s41421-024-00649-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-02doi.org/10.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-02doi.org/10.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-13doi.org/10.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-13doi.org/10.1073/pnas.2116506119
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-18doi.org/10.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-18doi.org/10.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-18doi.org/10.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-18doi.org/10.1073/pnas.2306145120
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-04doi.org/10.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-04doi.org/10.7554/eLife.68719
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ23.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-16doi.org/10.1038/s41422-020-00442-0
7D68 (No Gprot) B1PeptideGlucagonGLP-2Homo sapiensGLP-2-32020-12-16doi.org/10.1038/s41422-020-00442-0
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ22.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8FU6 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-2.92023-04-12doi.org/10.1016/j.cell.2023.02.028
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-24doi.org/10.1038/nature12393
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-17doi.org/10.1038/nature25153
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-02doi.org/10.1038/s41467-022-28683-0
7V35 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-3.52022-03-02doi.org/10.1038/s41467-022-28683-0
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-16doi.org/10.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-16doi.org/10.1038/s41586-023-06420-x
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-06doi.org/10.1073/pnas.2303696120
8JIT (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensMEDI0382-2.912023-09-06doi.org/10.1073/pnas.2303696120
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-13doi.org/10.1073/pnas.2303696120
8JIQ (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-15-3.42023-09-13doi.org/10.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-13doi.org/10.1073/pnas.2303696120
8JIU (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensSAR425899-2.762023-09-13doi.org/10.1073/pnas.2303696120
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-27doi.org/10.1074/jbc.RA120.013793
6WHC (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-3.42020-05-27doi.org/10.1074/jbc.RA120.013793
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-01doi.org/10.1126/science.aaz5346
6LMK (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.72020-04-01doi.org/10.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-01doi.org/10.1126/science.aaz5346
6LML (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.92020-04-01doi.org/10.1126/science.aaz5346
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ23.12020-08-12doi.org/10.1126/science.aba3373
6WPW (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-3.12020-08-12doi.org/10.1126/science.aba3373
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-2.842024-09-18doi.org/10.1038/s41421-024-00700-0
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-12doi.org/10.1038/s41467-020-17791-4




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